Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| angiogenesis in microvascular endothelial cells induced by glioma cells and inhibited by tumor necrosis factor in vitro. | neovascularization is a prerequisite for glioma growth, so inhibition of angiogenesis may achieve control of glioma growth. we examined whether glioma cells induce angiogenesis and proliferation in microvascular endothelial cells from fisher 344 rat brains by co-culture in a physical separation system with rat c6 glioma cells or rat t9 gliosarcoma cells. endothelial cells cultured on type 1 collagen formed capillary-like structures. c6 glioma cells co-cultured with endothelial cells promoted the ... | 1995 | 7541118 |
| the jeanne manery fisher memorial lecture 1994. molecular biology of rubella virus structural proteins. | rubella virus is a small, enveloped, positive-stranded rna virus in the togaviridae family and bears similarities to the prototype alphaviruses in terms of its genome organization and strategy for viral gene expression. despite being an important human pathogen, the cell biology of rubella virus remains poorly characterized. this review focuses on the molecular biology of rubella virus structural proteins, with emphasis on the proteolytic processing and maturation of virus structural proteins, t ... | 1994 | 7541628 |
| a polymorphism in the extracellular domain of the thyrotropin receptor is highly associated with autoimmune thyroid disease in females. | we and others have described previously a polymorphism at the first position of codon 52 (c52 --> a52) of the human thyrotropin receptor (htshr) gene. to determine its potential significance, we studied female (n = 100) and male (n = 25) patients with autoimmune thyroid disease (graves' disease, n = 91; hashimoto's thyroiditis, n = 34) and normal individuals [n = 121, female (n = 69), male (n = 52)]. screening was performed using acii restriction enzyme digestions of pcr-amplified genomic dna. a ... | 1995 | 7544179 |
| a pilot study of antituberculosis combinations comparing rifabutin with rifampicin in the treatment of hiv-1 associated tuberculosis. a single-blind randomized evaluation in ugandan patients with hiv-1 infection and pulmonary tuberculosis. | this pilot study was conducted at the joint clinical research centre (jcrc) in kampala, uganda, where tuberculosis (tb) is an epidemic health problem aggravated by the hiv-1 pandemic. | 1995 | 7548903 |
| [component analysis of variability as a method of differentiating simple effect from hazardous effect in toxicological experiments]. | the article forms the main requirements for every hazard criterion (valid, definite, statistically correct, differential, invariable, sensitive, integral). the suggested hazard criterion is based on additive components of general dispersion. those components reflect environmental influence (environmental effect) and influence of substance (effect of substance), then the components are compared according to fisher criterion (f). the criterion works in two-factor dispersion analysis. | 1995 | 7551696 |
| evidence of active cytomegalovirus infection in clinically stable hiv-infected individuals with cd4+ lymphocyte counts below 100/microliters of blood: features and relation to risk of subsequent cmv retinitis. | to determine the frequency and significance of cytomegalovirus (cmv) viremia and viruria in hiv-positive subjects with low cd4+ lymphocyte counts but with no clinical indications for culture, we studied 100 consecutive clinically stable subjects with cd4+ cells < or = 100/microliters of blood who agreed to culture of blood and urine. serum was tested for cmv antibody, p24 antigen, neopterin, and liver enzyme concentrations, and patients were offered funduscopic examination. subjects' records wer ... | 1995 | 7552494 |
| hla-dq1 is associated with clinical response and survival of patients with melanoma who are treated with interleukin-2. | the risk of developing melanoma, the natural history of this disease, and the response to therapy with biological reagents may be determined, in part, by a patient's human leukocyte antigen (hla) phenotype. in order to study this, the relationship between hla type and clinical response to therapy with interleukin-2 (il-2) was evaluated. | 1995 | 7553066 |
| william fisher norris: a philadelphia ophthalmologist. | in 1870, william fisher norris returned from studies abroad to find himself at the forefront of new developments in american ophthalmology. recognition of the specialty was just beginning and norris was named professor of ophthalmology in the department just established at the university of pennsylvania. norris was well-qualified for the job. as a member of a prominent philadelphia family he had the right connections. he was dedicated to the science of ophthalmology and to medical education. he ... | 1995 | 7555581 |
| nuclear p53 immunoreactivity in papillary thyroid cancers is associated with two established indicators of poor prognosis. | the tumor suppressor protein, p53, protects somatic cells against the accumulation of genomic alterations. cells harboring mutant or inactivated wild-type p53 protein are at risk for the development of genomic instability. nuclear accumulation of p53 protein is associated with the stepwise dedifferentiation of papillary carcinoma. we asked whether nuclear p53 accumulation is associated with two known indicators of poor prognosis in papillary carcinoma. we studied 55 consecutive papillary cancers ... | 1995 | 7556591 |
| hla and anti-gq1b igg antibody in miller fisher syndrome and guillain-barré syndrome. | we investigated serological human leukocyte antigen (hla) types in patients with histories of miller fisher syndrome (mfs) and guillain-barré syndrome (gbs) with ophthalmoplegia, in whom serum anti-gq1b igg antibody was present during the acute phase. we examined class i antigens (a, b and c) in 32 patients and class ii antigens (dr and dq) in 30, but found no association. we conclude that particular serologically defined hla types are not preferred for the immunoresponse of anti-gq1b igg antibo ... | 1995 | 7560017 |
| a meta-analysis of antidepressant outcome studies that involved children and adolescents. | a meta-analysis was performed of available studies that document response to antidepressant medications in the pediatric population, based upon guidelines developed in a methodological review of adult antidepressant response (greenberg, borstein, greenberg, & fisher, 1992). the 27 studies accessed through standard medical and psychological data bases were assessed against the following criteria: degree of blindness, placebo group design, rating issues, sample size, inclusion criteria, and other ... | 1995 | 7560133 |
| different biologic features of desmoid tumors in adult and juvenile patients: mr demonstration. | to demonstrate different biologic features of desmoid tumors on mri between juvenile and adult patients. | 2004 | 7560326 |
| effects of resistance training on strength, power, and selected functional abilities of women aged 75 and older. | to determine the effects of 12 weeks of progressive resistance strength training on the isometric strength, explosive power, and selected functional abilities of healthy women aged 75 and over. | 1995 | 7560695 |
| inhibition of the oncogene product p185erbb-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives. | the erbb-2 oncogene encodes a transmembrane protein tyrosine kinase which plays a pivotal role in signal transduction and has been implicated when overexpressed in breast, ovarian, and gastric cancers. naturally occurring benzoquinoid ansamycin antibiotics herbimycin a, geldanamycin (gdm), and dihydrogeldanamycin were found to potently deplete p185, the erbb-2 oncoprotein, in human breast cancer skbr-3 cells in culture. chemistry efforts to modify selectively the quinoid moiety of gdm afforded d ... | 1995 | 7562911 |
| erbb-2 oncogene inhibition by geldanamycin derivatives: synthesis, mechanism of action, and structure-activity relationships. | overexpression of the erbb-2 oncogene has been linked to poor prognosis in breast, ovarian, and gastric cancers. naturally occurring benzoquinoid ansamycin antibiotics herbimycin a, geldanamycin (gdm), and dihydrogeldanamycin were found to potently deplete p185, the erbb-2 oncoprotein, in human breast cancer skbr-3 cells in culture. chemistry efforts to modify selectively the ansa ring of gdm afforded derivatives with greater potency in vitro and in vivo. analogs demonstrated inhibition of p185 ... | 1995 | 7562912 |
| [multiple dural arteriovenous shunts presenting as subarachnoid hemorrhage: a case report]. | we present here an interesting case of multiple dural arteriovenous shunts (davs) in different locations at the same time. there have been very few reports on multiple davs. a 63-year-old man was admitted with a sudden onset of headache and vomiting. ct scan showed a typical subarachnoid hemorrhage (fisher group 3). cerebral angiogram (6 vessel study) revealed two dural arteriovenous shunts at the same time. one was located on the anterior fossa fed by the anterior ethmoidal artery, and the othe ... | 1995 | 7566430 |
| [comparison of instructions to authors of mexican medical journals and the vancouver requirements]. | to find out how much information of the vancouver norms (vannor) are given to prospective authors in the instructions for authors (ifa) in some mexican medical journals (mmj). | 2010 | 7569364 |
| somatosensory evoked potentials in the differential diagnosis between spinal cord compression and amyotrophic lateral sclerosis. | spinal cord compression (scc) often presents a similar clinical picture to amyotrophic lateral sclerosis (als). an early differential diagnosis is important because scc is a potentially treatable clinical disorder. we carried out a longitudinal study of 43 patients with an initial diagnosis of als, in order to ascertain the percentage of patients with scc, and to evaluate the usefulness of somatosensory evoked potentials (seps) in early diagnosis. thirty-three patients had a final diagnosis of a ... | 1995 | 7572066 |
| intermittent cyclical etidronate treatment maintains the mass, structure and the mechanical property of bone in ovariectomized rats. | we examined the mechanical properties of rat bones treated with etidronate intermittent cyclic treatment (etidronate-ict). fifty fisher rats, 7 months of age, underwent ovariectomy (ovx; n = 40) or sham operation (n = 10). the ovx rats were assigned to 4 groups injected with etidronate at the respective dose of 0, 2, 4, or 8 mg/kg of body weight (bw) 5 days each week for 2 weeks, followed by a 10-week period of no treatment. this regimen was repeated for 48 weeks. at the end of the treatment per ... | 1995 | 7572316 |
| role of the eosinophil in chronic vascular rejection of renal allografts. | obiliterative arteriopathy in chronic renal allograft rejection is caused by intimal smooth muscle proliferation accompanied by infiltration of lymphocytes, monocytes, and eosinophils. we investigated the role of the eosinophil in chronic rejection. twenty-four allograft nephrectomies were examined for the presence of eosinophils on hematoxylin-eosin-stained sections and using epifluorescence on fisher-giemsa-stained sections. among 15 cases with chronic rejection, eosinophils were detected in 1 ... | 1995 | 7573019 |
| the mechanisms by which hyperbaric oxygen and carbogen improve tumour oxygenation. | hyperbaric oxygen (hbo) has been proposed to reduce tumour hypoxia by increasing the amount of dissolved oxygen in the plasma. that this actually occurs has not been verified experimentally. this study was performed to explore changes in tumour oxygenation induced by treatment with normobaric and hyperbaric oxygen and carbogen. r3230ac mammary adenocarcinomas were implanted into fisher 344 rats. arterial blood gases, blood pressure and heart rate were monitored. tumour oxygenation was measured p ... | 1995 | 7577456 |
| tryptophan 250 on the alpha subunit plays an important role in flavin and aldehyde binding to bacterial luciferase. effects of w-->y mutations on catalytic function. | bacterial luciferase is a heterodimer (alpha beta) that catalyzes the oxidation of fmnh2 and a fatty aldehyde, resulting in light emission. to explore the nature of the flavin binding site with respect to the role of tryptophan residues, the catalytic and binding properties of single-point mutants of xenorhabdus luminescens luciferase with one of the eight tryptophans converted to a tyrosine residue were investigated by luminescence and fluorescence measurements. conversion of tryptophans 194 an ... | 1995 | 7578121 |
| use of synthetic peptides to identify surface-exposed, linear b-cell epitopes within outer membrane protein f of pseudomonas aeruginosa. | in a previous study (hughes ee, gilleland lb, gilleland he jr. [1992] infect immun 60:3497-3503), ten synthetic peptides were used to test for surface-exposed antigenic regions located throughout the length of outer membrane protein f of pseudomonas aeruginosa. an additional nine peptides of 11-21 amino acid residues in length were synthesized. antisera collected from mice immunized with each of the 19 synthetic peptides conjugated to keyhole limpet hemocyanin were used to determine which of the ... | 1995 | 7580798 |
| effects of dietary restriction on motor learning and cerebellar noradrenergic dysfunction in aged f344 rats. | fisher 344 rats were fed either ad libitum or with a diet containing a 40% reduction of calories beginning at 4 months of age. at 14 months and 22 months male rats were tested for their ability to learn a complex motor skill. at both ages the diet restricted rats reached criterion of performing 10 successful crosses in 10 min at an earlier time than ad libitum fed controls. at 22 months of age the diet restricted rats showed improved acquisition of running times for the task. male rats at 14 and ... | 1995 | 7583216 |
| the prediction of human exons by oligonucleotide composition and discriminant analysis of spliceable open reading frames. | discriminant analysis is applied to the problem of recognition 5'-, internal and 3'-exons in human dna sequences. specific recognition functions were developed for revealing exons of particular types. the method based on a splice site prediction algorithm that uses the linear fisher discriminant to combine the information about significant triplet frequencies of various functional parts of splice site regions and preferences of oligonucleotides in protein coding and intron regions (solovyev, law ... | 1994 | 7584412 |
| synthesis and antimicrobial activity of some new carbazoles, indazoles, quinolines, quinazolines and naphthalenes from 3-methyl-5-phenyl-6-benzylidene-2-cyclohexene-1-one. | reaction of the title compound (1) with phenylhydrazine using the fisher indole synthesis, resulted in the formation of the carbazole derivative (2). condensation of (1) benzaldehyde afforded the 6-benzylidene derivative (3). treatment of compound (3) with some hydrazines and hydrazides resulted in the formation of the indazoles (4). michael addition of some active methylene components with (3) gave quinolines (5) and naphthalenes (7). the reaction of (3) with urea and thiourea gave the uraciles ... | 1995 | 7598836 |
| modulation of antioxidant activities and immune response by food restriction in aging fisher-344 rats. | food restriction delays the loss of several cellular immune functions, retards the onset of many diseases during aging and, consequently, extends life span significantly in laboratory rodents. the present study was undertaken to determine whether the age-associated loss in immune function is linked to changes in microsomal and mitochondrial membranes of spleens in fischer-344 (f-344) male rats. in this study, we determined cytosolic superoxide dismutase activity (sod), fluidity and cholesterol c ... | 1995 | 7599247 |
| lysosomal chitobiase (ctb) and the g-protein gamma 5 subunit (gng5) genes co-localize to human chromosome 1p22. | previously isolated human placental cdna clones represent a fusion of specific rna sequences encoded by two genes: lysosomal chitobiase (ctb) and g-protein gamma 5 subunit (gng5, fisher and aronson, 1992a, 1992b). both genes have now been mapped to 1p by pcr analysis of somatic cell hybrids and further refined to 1p22 by fluorescence in situ hybridization (fish) using a yac clone that contains both the chitobiase and gamma 5 genes. | 1995 | 7606925 |
| echocardiographic evaluation of partial anomalous pulmonary venous drainage. | this study was undertaken to determine the accuracy of routine echocardiography in the detection of partial anomalous pulmonary venous drainage. | 1995 | 7608456 |
| the chance for fertility in adolescent boys after corrective surgery for varicocele. | we estimated the efficacy of a surgical procedure in adolescent patients with varicocele and left testicular atrophy. a total of 25 young men (mean age 23.6 years) had a complete andrological followup for 10 years after successful ligation of the spermatic vein (according to ivanissevich) to correct left varicocele and testicular atrophy. levels of follicle-stimulating hormone, luteinizing hormone and testosterone in the plasma were normal in all cases. patients were characterized into 2 distinc ... | 1995 | 7609165 |
| a review on 161 subtrochanteric fractures--risk factors influencing outcome: age, fracture pattern and fracture level. | the results obtained in 161 subtrochanteric fractures of the femur following treatment with a 95 degrees condylar blade plate or a dynamic condylar screw or a gamma nail were retrospectively analyzed. a 95 degrees angular blade plate was used in 107 cases, a dynamic condylar screw in 25, and a gamma nail in 29. there were 114 patients who were admitted after a simple fall and 47 who had sustained a high-energy trauma. in the type of trauma, associated lesions, iss, pre-existing diseases and fina ... | 1995 | 7610387 |
| ovulation induction in premature ovarian failure: a placebo-controlled randomized trial combining pituitary suppression with gonadotropin stimulation. | to determine the effect of pituitary suppression with a gnrh agonist (gnrh-a) on the success of ovulation induction with exogenous gonadotropins in patients with premature ovarian failure (pof). | 1995 | 7615102 |
| glutamine supplementation prevents the decrease of mitogen response after a treadmill exercise in rats. | the effect of glutamine (gln)-supplemented diet on mitogen response decreased immediately after a treadmill exercise was examined by measuring the proliferations of peripheral blood lymphocytes (pbl) with phytohemagglutinin (pha) and concanavalin a (cona) in male fisher rats. although the plasma gln concentration was significantly decreased in the control group immediately after a treadmill exercise (20 m/min, 60 min) compared to rested rats, plasma gln concentration of rats fed gln-supplemented ... | 1995 | 7616318 |
| [the chemistry of porphyrins and their precursors on the heme biosynthetic chain]. | there are two ways for numbering the positions of c and n atoms in the porphyrin ring. the fisher numeration is relatively old styled, but at present, is most widely employed among chemists because of its simpler and easier technique than that of the iupac numeration which is more effective in numbering the complicated structures of recent synthetic chemical including recent porphyrin derivatives. uroporphyrinogen iii, coproporphyrinogen iii and protoporphynogen ix have been described as the por ... | 1995 | 7616643 |
| age-dependent intestinal hydrolysis of valproate glucuronide in rat. | 1. age-dependent differences in the intestinal hydrolysis of the glucuronide conjugate of valproic acid were evaluated in the fisher-344 rat at 14 and 40 days, and 24 months of age. 2. hydrolysis occurred more quickly when incubations were conducted under anaerobic as compared with aerobic conditions. 3. the rate of hydrolysis of valproate glucuronide was most rapid in the contents of the large intestine (caecum and colon); no difference in rate was noted between age groups during incubations wi ... | 1995 | 7618349 |
| suppression of pulmonary metastases of rat mammary cancer by recombinant urokinase plasminogen activator inhibitor. | a pivotal point in the process of invasion and metastasis of cancer cells rests on the capability of those cells to present a proteolytic interface to the surrounding tissue matrix as well as to the lymphovascular channels supplying the tumor. the matb rat mammary cancer cells used in this study, along with a number of cancers of epithelial cell origin, provide that proteolytic interface by cell surface-bound plasmin. inhibition of tumor cell surface plasmin formation in this study was achieved ... | 1995 | 7618808 |
| [miller-fisher syndrome: one disease or two?]. | 1995 | 7619544 | |
| impact on progression-free survival of adjuvant cyclophosphamide, vincristine, doxorubicin (adriamycin), and dacarbazine (cyvadic) chemotherapy for stage i uterine sarcoma. a prospective trial. | to assess the impact on progression-free survival of the use of the multiagent chemotherapy regimen of cyclophosphamide, vincristine, doxorubicin (adriamycin), and dacarbazine (cyvadic) as adjuvant treatment for patients with stage i uterine sarcoma: 20 evaluable patients who underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy for stage i uterine sarcoma received adjuvant multiagent chemotherapy with vincristine sulfate 1 mg/m2 days 1 and 4, doxorubicin (adriamycin) 40 mg/ ... | 1995 | 7625366 |
| three surgical procedures for genuine stress incontinence: five-year follow-up of a prospective randomized study. | our purpose was to evaluate and compare the long-term results of the kelly plication, modified pereyra needle suspension, and burch urethropexy for the treatment of stress urinary incontinence in women. | 1995 | 7631729 |
| airways of a hyperresponsive rat strain show decreased relaxant responses to sodium nitroprusside. | the aim of the current studies was to investigate the possibility that a decreased relaxant response to nitric oxide (no) might contribute to strain-related differences in airway responsiveness in the rat. isolated tracheal rings from hyperresponsive. fisher rats were confirmed to be more responsive to carbachol [mean effective concentration (ec50) = 2.45 x 10(-7) m] than those from lewis (ec50 = 3.60 x 10(-7) m, p < 0.03) and aci (ec50 = 3.85 x 10(-7) m, p < 0.01) rats. sodium nitroprusside (sn ... | 1995 | 7631819 |
| [delay in hospitalization, diagnosis and surgical intervention in acute appendicitis]. | to assess if self-medication delays diagnosis and surgical treatment in acute appendicitis and increases morbidity, mortality and hospital stay as well. | 2006 | 7638527 |
| [physical prevention of thrombosis with the ankle joint with the motorized ankle joint movement device. initial results of a clinical study]. | between 1993 and 1994 the value of the "artroflow" device in deep venous thrombosis was tested in 95 trauma surgical high risk patients. parallel to the application of heparin and physical methods, the "artroflow" device was employed. the test and compare group showed an equal amount of risk parameters and comparable injuries. in all patients until full mobilization a weekly clinical examination, a compression sonography of the deep leg veins and a venous doppler examination was performed. in th ... | 1995 | 7638926 |
| mouse protection induced by pseudomonas aeruginosa pac1r and its defective mutants, salmonella minnesota re-mutant and escherichia coli o14. | pseudomonas aeruginosa pac1r and its defective mutants (acetone-killed bacteria), salmonella minnesota re mutant (acetone-killed bacteria and re-lps) and escherichia coli o14 (acetone-killed bacteria and enterobacterial common antigen, eca) were studied in a mouse active protection test. immunized mice were challenged with wild-type p. aeruginosa strains. it was established that p. aeruginosa lps-defective mutants induced cross-immunity against different fisher immunotypes of p. aeruginosa. s. m ... | 1995 | 7640675 |
| effects of adoptive immune transfers on murine leukemia virus-infection of rats. | in a rat model, we have investigated the effects of adoptively transferred virus-specific immune cells on an established retroviral infection of various organs. the experimental design required inoculation of neonatal fisher rats with a molecular clone of friend murine leukemia virus (f-mulv; fb29) which resulted in virus-specific immunotolerance, while infection of adult rats lead to a virus-specific humoral and cellular immune response. adoptive transfer of virus-specific immune cells from imm ... | 1995 | 7645245 |
| speech disorders in children treated for posterior fossa tumours: ataxic and developmental features. | the oromotor and speech abilities of 19 children (14 boys and five girls) who had been treated for posterior fossa tumour were evaluated using three assessment procedures. all subjects completed the frenchay dysarthria assessment and the fisher-logemann test of articulation competence. perceptual analyses were also performed on the subjects' connected speech samples. based on the three assessment procedures, 11 of the 19 tumour subjects were judged to be speech disordered. the 11 speech-disorder ... | 1994 | 7647388 |
| loss of cortical serotonin2a signal transduction in senescent rats: reversal following inhibition of protein kinase c. | using grease gap recordings, age-related changes in serotonin2a receptors were assessed in sensorimotor regions of the cortex by examining serotonin-induced facilitation of the n-methyl-d-aspartate depolarization in cortical wedges prepared from young adult (3-6 months) and senescent (22-34 months) fisher 344 rats. serotonin (10-100 microm) facilitated the n-methyl-d-aspartate depolarization in wedges from young adult rats in a concentration-dependent manner, whereas no facilitation was observed ... | 1995 | 7651616 |
| reduction of ovarian adhesions by the use of interceed. ovarian adhesion study group. | to evaluate the efficacy of interceed (tc7) absorbable adhesion barrier, an oxidized regenerated cellulose fabric, as a barrier to the development of postsurgical ovarian adhesions after surgery involving the ovaries. | 1995 | 7651638 |
| clinical predictors in the evaluation of a pelvic mass. | to determine the frequency by age of ovarian malignancies in women with a pelvic mass and to assess preoperative indicators for ovarian cancer. | 1995 | 7659211 |
| sb 201823-a antagonizes calcium currents in central neurons and reduces the effects of focal ischemia in rats and mice. | excessive calcium entry into depolarized neurons contributes significantly to cerebral tissue damage after ischemia. we evaluated the ability of a novel neuronal calcium channel blocker, sb 201823-a, to block central neuronal calcium influx in vitro and to reduce ischemic injury in two rodent models of focal stroke. | 1995 | 7660415 |
| surgical management of patients with endometrial cancer and cervical involvement. | to evaluate the role of extrafascial hysterectomy in the management of women with endometrial carcinoma and cervical involvement. | 1995 | 7664761 |
| sex determination from the pubis by discriminant function analysis. | a total of 122 adult human pubes (66 males and 56 females) are used in this study of a discriminant function analysis for determining sex from four pubic measurements: the angle formed by the middle line of the superior ramus and inferior ramus of pubis (in degrees, x1), subpubic angle (in degrees, x2), the minimum distance from the symphyseal surface to the obturator (in millimeters, x3), and the minimum thickness of the ischiopubic ramus (in millimeters, x4). the method introduced by fisher is ... | 1995 | 7665136 |
| growth inhibition of human tumor xenografts in nude mice by treatment with the antitumor agent 4,6-benzylidene-d1-d-glucose (p-1013). | 4,6-benzylidene-d1-d-glucose, p-1013, a deuterated benzaldehyde derivative which acts as a reversible protein synthesis inhibitor in vitro, was evaluated for antitumor effects in two human tumor xenografts implanced s.c. in nude mice. the drug, dissolved in isotonic saline, was given p.o. daily for several weeks. for evaluation of drug efficacy, mean tumor volume growth curves were generated and tumor volume doubling time (td) as well as per cent change in tumor size for the treated tumors compa ... | 1995 | 7670145 |
| preventing the itu syndrome or how not to torture an itu patient! part 2. | admission to an intensive therapy unit (itu) has been described as a 'necessary evil' (barrie-shevlin 1987), and some of the 'tortures' described in part i of this article (dyer 1995) may be an inevitable result of itu care. this does not mean that the development of the itu syndrome should be regarded as inevitable. many potential causes of the syndrome can be avoided or at least ameliorated. some suggested means of preventing the syndrome include designing itus with windows (keep et al 1980), ... | 1995 | 7670291 |
| multiple-trait genetic evaluation for one polychotomous trait and several continuous traits with missing data and unequal models. | a method for multiple-trait genetic evaluation for categorical and continuous traits was generalized to a polychotomous rather than a binary trait and to several continuous traits rather than one. any missing data pattern was allowed. breeding values were estimated based on an animal model with fixed and random effects differing among traits. equations in location parameters were solved iteratively within each fisher scoring step. in each round of scoring, new solutions of the residual covarianc ... | 1995 | 7673055 |
| prevalence and histologic significance of cervical human papillomavirus dna detected in women at low and high risk for cervical neoplasia. | to determine and compare the prevalence and histologic significance of human papillomavirus (hpv) nucleic acids in cervical specimens from women at low (routine hysterectomy) and high (suspicion of cervical neoplasia) risk for cervical neoplasia. | 1995 | 7675368 |
| outpatient treatment of pyelonephritis in pregnancy: a randomized controlled trial. | to compare the safety and efficacy of outpatient and inpatient treatment of pyelonephritis in pregnancy. | 1995 | 7675380 |
| evaluating contrast-enhancing brain lesions in patients with aids by using positron emission tomography. | to determine whether a noninvasive method for evaluating contrast-enhancing brain lesions in patients with the acquired immunodeficiency syndrome (aids) can accurately differentiate between lymphoma and nonlymphoma diagnoses. this method is based on toxoplasma serologic testing and positron emission tomography. | 1995 | 7677300 |
| transcriptional induction of beta-galactoside alpha-2,6-sialyltransferase in rat fibroblast by dexamethasone. | the beta-galactoside alpha-2,6-sialyltransferase activity of fisher rat fibroblasts is enhanced by dexamethasone while the activity of the beta-galactoside alpha-2,3-sialyltransferase remains unchanged. this glucocorticoid-dependent activation can be inhibited by the antagonist ru 38,486 and results from an elevated transcription rate of the 4.7-kb mrna previously characterized in rat fibroblasts, distinct from the 4.3-kb liver-restricted mrna. as shown by the binding of radiolabelled sambucus n ... | 1993 | 7678804 |
| age-related changes in duodenal adaptation after distal small bowel resection in rat. | two groups of male fisher 344 rats (young: 4 months old; aged: 25 months old) underwent either 70% distal small bowel resection or sham operation (small bowel transection). rats from each treatment group of each age were sacrificed on the 10th (n = 15: young rats; n = 13: aged rats) or 20th (n = 15: young; n = 13: aged) postoperative day (pod), and the duodenal mucosa was weighed and assayed for dna, rna, and protein contents, as well as for specific activities of the disaccharidase, sucrase, ma ... | 1993 | 7680301 |
| a decade (1982 to 1992) of pediatric cardiac transplantation and the impact of fk 506 immunosuppression. | the decade from 1982 through 1992 witnessed tremendous growth in pediatric cardiac transplantation. at children's hospital of pittsburgh 66 cardiac transplants were performed during this period (age range 7 hours to 18 years). the cause of cardiomyopathy was congenital (n = 30), cardiomyopathy (n = 29), myocarditis (n = 2), doxorubicin toxicity (n = 2), ischemic (n = 1), valvular (n = 1), and cardiac angiosarcoma (n = 1). nine children (14%) required mechanical circulatory support before transpl ... | 1993 | 7680396 |
| pattern recognition of the electroencephalogram by artificial neural networks. | a back-propagation network was trained to recognize high voltage spike-and-wave spindle (hvs) patterns in the rat, a rodent model of human petit mal epilepsy. the spontaneously occurring hvss were examined in 137 rats of the fisher 344 and brown norway strains and their f1, f2 and backcross hybrids. neocortical eeg and movement of the rat were recorded for 12 night hours in each animal and analog data were filtered (low cut: 1 hz; high cut: 50 hz) and sampled at 100 hz with 12 bit precision. a t ... | 1993 | 7681377 |
| response of phenobarbital- and ciprofibrate-exposed hepatocytes to growth factors in type i collagen gels. | the response of promoter-exposed hepatocytes to the complete hepatic mitogens hepatocyte growth factor (hgf), epidermal growth factor (egf) and acidic fibroblast growth factor (afgf) was studied. male fisher 344 rats were administered phenobarbital or ciprofibrate. hepatocytes were isolated at various time points and cultured in type i collagen gels, a 3-dimensional culture system that allows stable long-term hepatocyte differentiation. dna synthetic activity in response to addition of hgf, afgf ... | 1993 | 7682481 |
| effects of the immunosuppressant fk506 on a penetrating keratoplasty rejection model in the rat. | the immunosuppressive effects of fk506 on allogeneic corneal transplantation were tested in a rat model. | 1993 | 7686893 |
| placenta accreta is associated with elevated maternal serum alpha-fetoprotein. | to determine whether placenta accreta/percreta/increta is associated with elevation of second-trimester maternal serum alpha-fetoprotein (msafp) levels. | 1993 | 7687756 |
| surveillance of gram-negative bacteria for pseudomonas aeruginosa lipoprotein i using a monoclonal antibody. | we prepared an igg1 murine monoclonal antibody, ps2, that recognized the 8-kda outer membrane lipoprotein i of pseudomonas aeruginosa. the biodot-immunoblot technique was used to test 470 bacterial isolates for their reactivity with mab ps2. ps2 recognized 298 of 300 p. aeruginosa clinical isolates for a sensitivity of 99.3%. ps2 reacted with all fisher-devlin immunotype and international antigenic type p. aeruginosa strains. forty-seven isolates of other pseudomonas species were tested and only ... | 1993 | 7689535 |
| growth-related gene expression in early cholestatic liver injury. | extrahepatic biliary obstruction initiates cholestasis, bile duct proliferation, periportal fibrosis, and, eventually, lethal biliary cirrhosis. little is known about the genetic regulation of the cellular proliferation and differentiation that begins with the onset of bile duct obstruction. to focus this and future gene expression studies, we sought to determine the time frame for growth-related gene expression and questioned whether the in vivo expression of the protooncogenes h-ras and c-myc ... | 1993 | 7690161 |
| a modified uridine in the first position of the anticodon of a minor species of arginine trna, the argu gene product, from escherichia coli. | the argu (dnay) gene product, a minor trna(arg), from escherichia coli has the anticodon n*cu with an unidentified modified nucleoside n* in position 34 [kiesewetter, s., fisher, w. & sprinzl, m. (1987) nucleic acids res. 15, 3184]. in the present study, argu trna was purified from e. coli a19 strain and nucleoside n* was characterized by the tlc and hplc analyses. nucleoside n* was found to be different from any naturally occurring modified nucleosides. from unfractionated e. coli trna species, ... | 1993 | 7690702 |
| nosocomial infections in the human immunodeficiency virus-infected patient: a two-year survey. | because hiv-infected patients are often hospitalized and have major defects in host defenses, we surveyed all hiv-infected patients admitted to our institution to determine incidence of infections and to risk factors for nosocomial infections. | 1994 | 7695111 |
| [miller-fisher syndrome and encephalitis of the brain stem]. | 1995 | 7695941 | |
| fisher symposium. future directions in alzheimer's disease research. washington, d.c., may 24-26, 1994. proceedings. | 1994 | 7700428 | |
| free d-amino acids in human cerebrospinal fluid of alzheimer disease, multiple sclerosis, and healthy control subjects. | this is the first report of the presence of free d-amino acids in lumbar and ventricular human cerebrospinal fluid (csf) of individuals with alzheimer disease (ad) compared with csf of normal control subjects and with individuals affected by multiple sclerosis, as an unrelated neurologic disorder. free d-amino acids are present at significantly higher levels in ad csf than normal csf, whereas in the csf of patients affected by multiple sclerosis, d-amino acids occurs at the same level as in the ... | 1994 | 7702702 |
| morphometric investigation on nuclear and nucleolar arrangement and agnor content in the rat hippocampus under normal and ischemic conditions. | a morphometric analysis of constituents of the rat hippocampus was performed in the different hippocampal regions that are known to be vulnerable in various degrees to experimental global ischemia. in the hippocampus formation of the normal fisher rat the number and areas of neuronal nuclei and of their constituents, nucleoli and agnor particles, were counted and measured. nuclear and nucleolar size were different in the various parts of the ammon's formation. agnors, i.e. silver stainable prote ... | 1994 | 7703682 |
| an avirulent icp34.5 deletion mutant of herpes simplex virus type 1 is capable of in vivo spontaneous reactivation. | the herpes simplex virus type 1 (hsv-1) icp34.5 gene is a neurovirulence gene in mice. in addition, some icp34.5 mutants have been reported to have a reduced efficiency of induced reactivation as measured by in vitro explantation of latently infected mouse ganglia. however, since spontaneous reactivation is almost nonexistent in mice, nothing has been reported on the effect of icp34.5 mutants on spontaneous reactivation in vivo. to examine this, we have deleted both copies of the icp34.5 neurovi ... | 1995 | 7707530 |
| effects of prophylactic intrathecal administrations of nicardipine on vasospasm in patients with severe aneurysmal subarachnoid haemorrhage. | calcium antagonists are currently most widely used for chronic cerebral vasospasm after aneurysmal subarachnoid haemorrhage (sah). however, the vasodilatory effects of systemically administered calcium antagonists can be limited secondary to hypotension. we previously compared intrathecal and intravenous routes of administration of nicardipine. intrathecal administration of nicardipine significantly dilated spastic basilar arteries on day 7 in a two-haemorrhage canine model of vasospasm. in the ... | 1994 | 7709781 |
| a rodent model for hemoglobin switching utilizing high performance liquid chromatography. | it has long been recognized that a treatment for beta hemoglobin chain anomalies could result if a way to reverse the hb f to hb a switch in humans were found. studies of hemoglobin switching have been hampered by the fact that small animals normally used in the laboratory do not have a true hb f. however, several small animal models which take advantage of a switch in minor beta chain proportions in certain strains of inbred mice and rats have been proposed and used. the use of these models has ... | 1994 | 7713744 |
| breast silicone implants and risk of systemic lupus erythematosus. | the uncertain safety of breast implants has been a major controversy of late, both in the lay press and in the scientific literature. a case-control study had been performed in the philadelphia metropolitan area during 1985-1987 to investigate potential risk factors for systemic lupus erythematosus (sle). a total of 219 eligible cases who met the american rheumatism association criteria for sle were identified from the medical practices of cooperating rheumatologists in the area; 195 (89%) of th ... | 1994 | 7722556 |
| suppression of graft rejection in rat keratoepithelioplasty by anterior chamber inoculation of donor lymphocytes. | a newly developed model of keratoepithelioplasty (kep) in the rat was used to analyze the effect of anterior chamber-associated immune deviation on the suppression of corneal allograft rejection. the right eyes of fisher rats received an anterior chamber (ac) injection of lymphocyte suspension from dark agouti (da) rats (dal group) or phosphate-buffered saline (positive control group). seven days later, da corneal lenticules were grafted onto both eyes of the recipients. delayed type hypersensit ... | 1994 | 7723200 |
| a randomized trial of prophylactic doxycycline for curettage in incomplete abortion. | to determine whether prophylactic doxycycline at suction curettage for incomplete abortion decreases the rate of postoperative pelvic infection. | 1995 | 7724097 |
| second-trimester abortion by intramuscular 15-methyl-prostaglandin f2 alpha or intravaginal prostaglandin e2 suppositories: a randomized trial. | to compare intramuscular (im) prostaglandin 15 methyl-f2 alpha (15m-pgf2 alpha) with prostaglandin e2 (pge2) vaginal suppositories for second-trimester abortion in terms of efficacy and side effects. | 1995 | 7724098 |
| membrane protein alterations in rodent erythrocytes and synaptosomes due to aging and hyperoxia. | we have applied the technique of electron paramagnetic resonance (epr) protein-specific spin labeling to the study of membrane protein alterations occurring during age and exposure to isobaric hyperoxia. cortical synaptosomes and erythrocyte membranes (ghosts) were isolated from young rodents (fisher 344 rats or mongolian gerbils, 3-4 months of age) and aged rodents (age 22-27 months for rats, greater than 15 months for gerbils). membrane proteins were spin labeled with the thiol-specific spin l ... | 1995 | 7727544 |
| objective assessment of image quality. ii. fisher information, fourier crosstalk, and figures of merit for task performance. | figures of merit for image quality are derived on the basis of the performance of mathematical observers on specific detection and estimation tasks. the tasks include detection of a known signal superimposed on a known background, detection of a known signal on a random background, estimation of fourier coefficients of the object, and estimation of the integral of the object over a specified region of interest. the chosen observer for the detection tasks is the ideal linear discriminant, which w ... | 1995 | 7730951 |
| neoplastic meningitis presenting with ophthalmoplegia, ataxia, and areflexia (miller-fisher syndrome) | 1995 | 7733836 | |
| [lymphoid depletion type 4 hodgkin disease. anatomoclinical review of 35 cases]. | the pathological material of 35 patients with hodgkin's disease lymphocyte-depletion type (type 4) is reviewed with an immunohistochemistry study on paraffin-embedded sections. the new pathologic data are compared with clinical features. these 35 patients are 4.7% of 742 previously untreated patients managed in this institution from 1960 to 1991. the diagnosis of 31 of the 35 patients was rectified, 17 to non-hodgkin's lymphoma (12 unclassifiable and five anaplastic ki-1 positive) and 14 to anot ... | 1994 | 7734769 |
| characterization of ganglioside associated with the thyrotrophin receptor. | the receptor protein for thyrotrophin (thyroid-stimulating hormone; tsh) is associated with a glycosphingolipid moiety. the protein belongs to the family of receptors that couple to guanine nucleotide binding proteins; the glycosphingolipid contains sialic acid and belongs to the family of gangliosides. this report defines the structure of the receptor ganglioside in the fisher rat thyroid cell line (frtl-5). receptor protein was purified by tsh affinity chromatography from frtl-5 cells, biosynt ... | 1994 | 7734842 |
| immunoglobulins from rats that are resistant to adjuvant arthritis suppress the disease in arthritis-susceptible rats. | the therapeutic effect of high doses of polyclonal immunoglobulins has been well established in various b cell-associated autoimmune diseases. in the present work we have examined the effect of low doses of immunoglobulins in adjuvant arthritis, a t cell-associated disease in the lewis rat. lewis rats were treated with purified rat immunoglobulins as well as their fc and f(ab')2 fragments and their protective effect on adjuvant arthritis was evaluated. we found that early as well as late treatme ... | 1995 | 7737299 |
| effects of a calcium antagonist, manidipine, on progressive renal injury associated with mild hypertension in remnant kidneys. | the present study was conducted to determine the effects of a calcium antagonist, manidipine, on the outcome of a remnant kidney model of chronic renal failure in fisher 344 rats. after sham operation or five-sixths nephrectomy (nx), the rats were assigned to one of the following groups according to the administered amount of drug and were provided a specified diet for 12 weeks: group 1 (sham), diet without manidipine; group 2 (nx), diet without manidipine; group 3 (nx), diet with 0.0004% manidi ... | 1995 | 7738423 |
| discordant expression and variable numbers of neighboring gga- and gaa-rich triplet repeats in the 3' untranslated regions of two groups of messenger rnas encoded by the rat polymeric immunoglobulin receptor gene. | an unusual s1-nuclease sensitive microsatellite (stms) has been found in the single copy, rat polymeric immunoglobulin receptor gene (pigr) terminal exon. in fisher rats, elements within or beyond the stms are expressed variably in the 3' untranslated regions (3'utrs) of two 'groups' of pigr-encoded hepatic mrnas (pig-r) during liver regeneration. stms elements include neighboring constant regions (a 60-bp d[ga]-rich tract with a chi-like octamer, followed by 15 tandem d[gga] repeats) that merge ... | 1995 | 7739889 |
| immunological effects of 2-methoxyethanol administered dermally or orally to fischer 344 rats. | exposure of rats to 2-methoxyethanol (me) by gavage for 10 consecutive days results in immunotoxicity. to determine whether dermal exposure to me also induces immunotoxicity, undiluted me was applied to fisher 344 male rats at dose levels of 150, 300, 600, 900 or 1200 mg/kg/day on shaved occluded test sites for 4 consecutive days. decreased thymus weights were produced by all doses of me, while reductions in spleen weight were observed at doses of 900 mg/kg/day me or greater. the alterations in ... | 1995 | 7740549 |
| microvascular response to ischemia, and endothelial ultrastructure, in disused skeletal muscle. | it has previously been demonstrated that muscle atrophy associated with aging and disuse is accompanied by changes in microvascular function including absolute loss of capillaries, increased mean red blood cell velocity (vrbc), and absence of reactive hyperemia. the purpose of the present study was to determine whether disuse could account for these changes. the right extensor digitorum longus muscle in male fisher 344 rats was subjected to 15 days of disuse through the neural application of tet ... | 1995 | 7746162 |
| actions of alcohol on immunity and neoplasia in fetal alcohol exposed and adult rats. | alterations of immune function can result not only from alcohol consumption by the adult human or animal, but also from fetal alcohol exposure (fae). we have demonstrated long-lasting effects of fae on t cell function and effects of adult ethanol (etoh) consumption on tumorigenesis. here, we present recent data that demonstrate that 1) fae alters the biphasic pattern of thymocyte activation during peripubertal development probably due to effects other than the cd3 pathway; and 2) the long-lastin ... | 1993 | 7748350 |
| gdnf protects nigral dopamine neurons against 6-hydroxydopamine in vivo. | glial cell line-derived neurotrophic factor (gdnf), a novel member of the tgf-beta superfamily, has been shown to promote the survival and morphological differentiation of fetal dopamine neurons in culture and increase dopamine levels and metabolism in adult rats. since several other trophic factors are able to rescue specific populations of mature cns neurons following injury, the present study was designed to investigate a possible neuroprotective role by gdnf for midbrain dopamine neurons in ... | 1995 | 7749731 |
| rat strain and age differences in kainic acid induced seizures. | this study reports comparative dose-response data for kainic acid (ka) induced seizures in juvenile (35-40 days old) and adult (70-90 days old) wistar-furth (wf), fisher 344 (f344), sprague-dawley (sd) and long-evans hooded (leh) rats. juvenile male wf (n = 51), f344 (n = 55), sd (n = 60), leh (n = 50) and adult male wf (n = 48), f344 (n = 52), sd (n = 52), leh (n = 53) rats were given ka 6, 8, 10, 12 or 14 mg/kg, sc. as previously demonstrated adult wf and f344 rats showed the greatest sensitiv ... | 1995 | 7750511 |
| localization of 5-ht2a receptor mrna by in situ hybridization in the olfactory bulb of the postnatal rat. | the olfactory bulb receives a dense serotonergic input and appears to require serotonergic input in early olfactory associational learning. however, it is not known which cell types receive the serotonergic input or whether the cells express markers for the input throughout life. these issues need resolution in order for the mechanisms of serotonergic interactions to be better understood. the mrna for the 5-ht2a receptor was localized in the olfactory bulb of postnatal day 1, 2, 14 and 9-month-o ... | 1995 | 7751437 |
| the melanoma differentiation-associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cells. | the combination of recombinant human fibroblast interferon (ifn-beta) and the antileukemic compound mezerein (mez) induces terminal differentiation with an irreversible loss of proliferative capacity in human melanoma cells. using subtraction hybridization, cdnas were identified that display enhanced expression in terminally differentiated and growth arrested human melanoma cells (jiang and fisher, 1993; jiang et al., 1994a). a specific melanoma differentiation-associated (mda) cdna, mda-6, is d ... | 1995 | 7753561 |
| chiari i malformation: association with hypophosphatemic rickets and mr imaging appearance. | to evaluate for an association between familial hypophosphatemic rickets (fhr) and chiari i malformation (cm1). | 1995 | 7754003 |
| thyroglobulin-reactive t lymphocytes in thyroiditis-prone bb/wor rats. | autoimmune lymphocytic thyroiditis (lt) is a common cause of primary hypothyroidism. autoreactive t lymphocytes are clearly associated with this disorder, but their pathogenic role in spontaneously occurring lt remains to be established. in the present study, thyroglobulin-reactive t lymphocytes were cultured from young, unprimed lt-prone bb/wor rats before the age of spontaneously-occurring lt. although similar investigations have been conducted in animal models for experimental autoimmune thyr ... | 1995 | 7759784 |
| [miller-fisher syndrome. role of campylobacter jejuni infection]. | 1995 | 7761368 | |
| group sequential comparison of changes: ad-hoc versus more exact method. | there are many clinical trials in which we are interested in comparing changes in responses between two treatment groups sequentially. investigators might assume a simple linear model, take the average of the ordinary least square estimators of slope within each treatment group, and use the standardized difference between these two averages as the test statistic at each interim analysis. ad-hoc construction of the boundary values for interim analysis might be based on group sequential methods wh ... | 1995 | 7766776 |
| surgical management of atheroembolization. | atheroembolization may cause limb loss or organ failure. surgical outcome data are limited. we report the largest series of atheroembolization focusing on patterns of disease, surgical treatment and outcome. | 1995 | 7769735 |
| more than one previous cesarean delivery: a 5-year experience with 435 patients. | to evaluate the obstetric outcome of patients who have had more than one previous cesarean delivery, and to compare it with that of patients with one previous cesarean. | 1995 | 7770261 |