Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| developmental plasticity of the microscopic placental architecture in relation to litter size variation in the common marmoset monkey (callithrix jacchus). | fetal demand, shaped by factors such as number of fetuses, may alter placental regulation of exchange, even when maternal nutrition restriction is not overt. the marmoset is an interesting model in which to examine this aspect of placental function due to unique placentation that leads to multiple fetuses sharing a unified placental mass. we demonstrated previously that the triplet marmoset placenta exhibits significantly higher efficiency than does the twin placenta. here, we test the hypothesi ... | 2009 | 19038443 |
| correlations between hand preference and cortical thickness in the secondary somatosensory (sii) cortex of the common marmoset, callithrix jacchus. | cortical asymmetries are well established in humans for language and motor regions and correlate with handedness. here the authors investigate structural differences in the hemispheres of left- and right-handed common marmosets using surface photography and histology. the hand preferences of 11 marmosets were assessed over their adult life span using a simple reaching task. a significant correlation was found between the length of the right lateral sulcus/brain weight and the % right-hand prefer ... | 2008 | 19045953 |
| the common marmoset (callithrix jacchus) as a model for histone and protamine expression during human spermatogenesis. | histone to protamine exchange, in man, is only 80% complete and spermatozoal histones are highly acetylated suggesting that their associated genes may be involved in early gene expression in the embryo. | 2009 | 19056771 |
| molecular cloning and characterization of the common marmoset huntingtin gene. | we report here for the first time the isolation and identification of the common marmoset (callithrix jacchus) huntingtin (htt) gene, whose ortholog in humans is known to be related to huntington's disease (hd). a 9396 nucleotide complementary dna (cdna) carrying the putative full-length open reading frame of the marmoset htt gene was identified, and highly conserved nucleotide and amino acid sequences among primates were observed. based on this data and using tools evaluated for the detection o ... | 2009 | 19073238 |
| differential expression of glut2 in pancreatic islets and kidneys of new and old world nonhuman primates. | diabetes is a growing public health concern, and animal models of this disease are necessary for a full understanding of disease pathogenesis, progression, clinical sequelae, and treatment options. in particular, nonhuman primate models of diabetes are important because of their close genetic relationship to humans. although numerous old world primate models have been described, few studies have examined the possibility of using new world monkeys as an animal model for this disease. streptozotoc ... | 2009 | 19073904 |
| the hormonal induction of cervical remodeling in the common marmoset monkey (callithrix jacchus). | controversy still exists regarding the involvement of relaxin (rlx) in cervical reorganization throughout parturition in the human, despite its well-known role in facilitating extensive extracellular matrix (ecm) remodeling in diverse organs. therefore, the aim of the present study was to examine the influence of rlx and estrogen (e2) on the cervical tissue of the common marmoset monkey. two experimental designs were used: 1) in vivo analysis of the intracervical diameter under locally applied r ... | 2009 | 19106202 |
| the functional correlates of jaw-muscle fiber architecture in tree-gouging and nongouging callitrichid monkeys. | common (callithrix jacchus) and pygmy (cebuella pygmaea) marmosets and cotton-top tamarins (saguinus oedipus) share broadly similar diets of fruits, insects, and tree exudates. marmosets, however, differ from tamarins in actively gouging trees with their anterior dentition to elicit tree exudates flow. tree gouging in common marmosets involves the generation of relatively wide jaw gapes, but not necessarily relatively large bite forces. we compared fiber architecture of the masseter and temporal ... | 2009 | 19140215 |
| a molecular blueprint of gene expression in hippocampal subregions ca1, ca3, and dg is conserved in the brain of the common marmoset. | recent studies in rodents have shown that there are significant differences in gene expression profiles between the hippocampal subregions ca1, ca3, and dg. these differences in molecular make-up within the hippocampus most likely underlie the differences in morphology, physiology, and vulnerability to insults that exist between the subregions of the hippocampus and are as such part of the basic molecular architecture of the hippocampus. the aim of this study was to investigate at large scale wh ... | 2009 | 19156849 |
| central oxytocin stimulates luteinizing hormone release in the marmoset, a primate which fails to show lactationally-lnduced infertility. | in several species, including humans, suckling is known to suppress pulsatile gonadotrophin secretion and substantially reduce fertility (1). during suckling high titres of oxytocin are present in both plasma (2, 3) and cerebrospinal fluid (csf) (4) and there is some evidence that oxytocin is inhibitory to gonadotrophin secretion by an action on t h e central nervous system, (5, 6). the common marmoset, however, has a different physiological response and fails to show lactational infertility; ov ... | 1990 | 19215367 |
| preparation and evaluation of ethyl [(18)f]fluoroacetate as a proradiotracer of [(18)f]fluoroacetate for the measurement of glial metabolism by pet. | changes in glial metabolism in brain ischemia, alzheimer's disease, depression, schizophrenia, epilepsy and manganese neurotoxicity have been reported in recent studies. therefore, it is very important to measure glial metabolism in vivo for the elucidation and diagnosis of these diseases. radiolabeled acetate is a good candidate for this purpose, but acetate has little uptake in the brain due to its low lipophilicity. we have designed a new proradiotracer, ethyl [(18)f]fluoroacetate ([(18)f]efa ... | 2009 | 19217527 |
| comparative biology of aging. | virtually, all research on basic mechanisms of aging has used species that are short lived and thus demonstrably unsuccessful at combating basic aging processes. a novel comparative approach would use a diversity of populations and species, focusing on those with particularly long, healthy lives, seeking the causative mechanisms that distinguish them from shorter lived relatives. species of interest from this perspective include the naked mole rat, a mouse-size rodent that lives up to 30 years i ... | 2009 | 19223603 |
| the maintenance of traditions in marmosets: individual habit, not social conformity? a field experiment. | social conformity is a cornerstone of human culture because it accelerates and maintains the spread of behaviour within a group. few empirical studies have investigated the role of social conformity in the maintenance of traditions despite an increasing body of literature on the formation of behavioural patterns in non-human animals. the current report presents a field experiment with free-ranging marmosets (callithrix jacchus) which investigated whether social conformity is necessary for the ma ... | 2009 | 19223965 |
| vocalisations of wild common marmosets are influenced by diurnal and ontogenetic factors. | the vocalisations of wild common marmosets, callithrix jacchus, were recorded to investigate whether call rate by individuals is affected by time of day, age, sex or dominance rank within a group. we also investigated how vocalisation pitch was affected by age, focussing on a single common call, the trill call. adults vocalised more than juveniles or infants during the majority of daylight hours. only the call rate of juveniles varied significantly over the day. no differences were found between ... | 2009 | 19224328 |
| hand preference predicts reactions to novel foods and predators in marmosets (callithrix geoffroyi). | in chimpanzees (pan troglodytes) and common marmosets (callithrix jacchus), left-handed individuals are less likely than right-handed individuals to explore new objects and situations, suggesting a relationship between the hemispheric specialization of emotional states and motor function. to further explore this relationship and to test the hypothesis that fearfulness is related to hand preference, we assessed willingness to approach, sniff, and taste novel foods, and the duration of freeze reac ... | 2009 | 19236141 |
| a novel embryonic stem cell line derived from the common marmoset monkey (callithrix jacchus) exhibiting germ cell-like characteristics. | embryonic stem cells (esc) hold great promise for the treatment of degenerative diseases. however, before clinical application of esc in cell replacement therapy can be achieved, the safety and feasibility must be extensively tested in animal models. the common marmoset monkey (callithrix jacchus) is a useful preclinical non-human primate model due to its physiological similarities to human. yet, few marmoset esc lines exist and differences in their developmental potential remain unclear. | 2009 | 19251728 |
| architectural subdivisions of medial and orbital frontal cortices in the marmoset monkey (callithrix jacchus). | although the common marmoset has become a model for the study of several neurological conditions that affect the frontal lobe, knowledge of the boundaries of the areas located in the orbital and medial frontal regions has remained incomplete. here we examined histological sections stained for myelin, nissl substance, and cytochrome oxidase, allowing identification of likely homologues of most of the architectural fields defined in old world monkeys. ventrally, we identified three granular fields ... | 2009 | 19260047 |
| behavioral and hormonal response of common marmosets, callithrix jacchus, to two environmental conditions. | captive animals of several species change their behavioral pattern and hormonal profile in response to physical (for example, cage size and temperature) and social (for example, group size and social isolation) modification of their environment. to evaluate the effect of environmental change in captivity, the affiliative (contact/proximity and allogrooming) and individual (approach, leaving, scent mark, locomotion, and autogrooming) behavior of five family groups of common marmosets, callithrix ... | 2009 | 19277829 |
| the marmoset model of gb virus b infections: adaptation to host phenotypic variation. | worldwide, approximately 170 million people are chronically infected with hepatitis c virus (hcv), and chronic infection frequently progresses to serious liver disease, including cirrhosis and hepatocellular carcinoma. gb virus b (gbv-b), the virus phylogenetically most closely related to hcv, causes hepatitis in tamarins. we have demonstrated the suitability of the tamarin as a host for gbv-b and as a surrogate nonhuman primate model for hcv infection, and we have initiated studies of gbv-b inf ... | 2009 | 19279089 |
| endometrial and cervical polyps in 22 baboons (papio sp.), 5 cynomolgus macaques (macaca fascicularis) and one marmoset (callithrix jacchus). | endometrial and cervical polyps are masses of endometrium or cervical epithelium that bulge into the uterine or cervical lumen. the physiopathology and contributing factors of endometrial polyps development are still unknown. | 2009 | 19281481 |
| male fertility and strategies for fertility preservation following childhood cancer treatment. | infertility in the male is a potential complication of childhood cancer treatment for long-term survivors. the risk is dependent primarily on the treatment used, but also on the underlying disease. chemotherapy (especially alkylating agents) and radiotherapy, even in low doses, may damage the seminiferous epithelium and impair spermatogenesis in both children and adults. leydig cell function and testosterone production are generally preserved after chemotherapy and low dose radiotherapy, whilst ... | 2009 | 19293606 |
| social learning and mother's behavior in manipulative tasks in infant marmosets. | high levels of social tolerance are considered to promote social learning, as they allow direct observation of a manipulating conspecific and facilitate scrounging. owing to tolerance toward infants, infancy is thought to be especially suited for learning socially transmitted behaviors. despite this, few studies have investigated social learning of infants, particularly in manipulative tasks where observation might be most helpful. here, we investigated (1) the influence of social learning on ta ... | 2009 | 19319974 |
| manganese-enhanced mri visualizes v1 in the non-human primate visual cortex. | mri at 7 tesla has been used to investigate the accumulation of manganese in the occipital cortex of common marmoset monkeys (callithrix jacchus) after administering four fractionated injections of 30 mg/kg mncl(2) . 4h(2)o in the tail vein. we found a statistically significant decrease in t(1) in the primary (v1) and secondary (v2) areas of the visual cortex caused by an accumulation of manganese. the larger t(1) shortening in v1 (deltat(1) = 640 ms) relative to v2 (deltat(1) = 490 ms) allowed ... | 2009 | 19322808 |
| characterization of obese phenotypes in a small nonhuman primate, the common marmoset (callithrix jacchus). | this report explores aspects of developing obesity in two captive populations of common marmosets (callithrix jacchus), a small primate with a short lifespan that may be of value in modeling chronic aspects of obesity acquisition and its lifetime effects. two populations were examined. in study 1, body composition, lipid parameters, and glucose metabolic parameters were measured in a population of 64 adult animals. animals classified as obese (>80th percentile relative fat based on sex) displaye ... | 2009 | 19325546 |
| establishment of lethal inhalational infection with francisella tularensis (tularaemia) in the common marmoset (callithrix jacchus). | susceptibility and lethality studies of inhalational tularaemia were undertaken using the common marmoset (callithrix jacchus) to determine its suitability as a non-human primate model. pairs of marmosets were exposed to varying challenge doses of francisella tularensis by the airborne route and monitored for up to 14 days postchallenge (p.c.). lethal infection was achieved following a retained dose of less than 10 bacterial colony-forming units (cfu). however, precise ld(50) determination was n ... | 2009 | 19335549 |
| clinical, pathological, and immunologic aspects of the multiple sclerosis model in common marmosets (callithrix jacchus). | the efficacy of many new immunomodulatory therapies for multiple sclerosis (ms) patients has often been disappointing, reflecting our incomplete understanding of this enigmatic disease. there is a growing awareness that, at least in part, there may be limited applicability to the human disease of results obtained in the widely studied ms model experimental autoimmune encephalomyelitis in rodents. this review describes the experimental autoimmune encephalomyelitis model developed in a small neotr ... | 2009 | 19337065 |
| effects of elevated circulating cortisol concentrations on maternal behavior in common marmoset monkeys (callithrix jacchus). | both acute and chronic stress can impair maternal behavior and increase rates of infant abuse in several species. the mechanisms inducing these effects are unknown, but experimental manipulation of circulating corticosterone levels alters maternal behavior in rats, and circulating or excreted cortisol concentrations have been found to correlate either positively or negatively with maternal behavior in humans and nonhuman primates. in this study, therefore, we experimentally tested the hypothesis ... | 2009 | 19362777 |
| variations in male parenting behavior and physiology in the common marmoset. | infant survival and wellbeing is dependent upon good parenting skills. in some species of primates, fathers are necessary to ensure both positive developmental and social outcomes for their offspring. common marmosets and the related cotton-top tamarin monkeys provide extensive paternal care of multiple offspring and are essential for infant survival. however, we have found significant variation in a father's motivation to respond to infant stimuli. additionally, marmoset males who are experienc ... | 2009 | 19367571 |
| intrauterine hyperexposure to dexamethasone of the common marmoset monkey revealed normal cerebral metabolite concentrations in adulthood as assessed by quantitative proton magnetic resonance spectroscopy in vivo. | animal models of human brain disorders often have to rely on non-human primates because of their immunological, physiological, and cognitive similarities to humans. | 2009 | 19374665 |
| two new test methods to quantify motor deficits in a marmoset model for parkinson's disease. | the validity of the common marmoset (callithrix jacchus) as a model for human disease depends on the development of parameters with clinical relevance. we tested the effect of treatment with mptp in two newly developed non-invasive motor behavioral paradigms in the context of parkinson's disease. the "tower" was designed to quantify the marmoset's natural jumping behavior as a measure for akinesia, the "hourglass" to test the marmoset's natural righting reflex as measure for rigidity, analogous ... | 2009 | 19378465 |
| fetal signaling through placental structure and endocrine function: illustrations and implications from a nonhuman primate model. | the placenta is a transmitter of fetal need and fetal quality, interfacing directly with maternal physiology and ecology. plasticity of placental structure and function across the developmental timeframe of gestation may serve as an important tool by which a fetus calibrates its growth to shifting maternal ecology and resource availability, and thereby signals its quality and adaptability to a changing environment. signals of this quality may be conveyed by the size of the placental interface, a ... | 2009 | 19384862 |
| treatment of giardiasis in common marmosets (callithrix jacchus) with tinidazole. | giardia intestinalis is a common protozoan parasite that can infect many laboratory animal primates, although its role as a contributor to the induction of gastrointestinal disease remains unclear. this study sought to investigate the prevalence of giardia in a colony of common marmosets by using a giardia antigen-capture assay and to address the possible eradication of this infection by using tinidazole, an antiprotozoal similar to metronidazole but requiring fewer doses. among 31 colony marmos ... | 2009 | 19389310 |
| temporal rules in vocal exchanges of phees and trills in common marmosets (callithrix jacchus). | marmosets exchange two types of calls: phees and trills. we played back phees and trills to investigate the temporal rules of vocal exchanges using ten captive common marmosets (callithrix jacchus). the marmosets usually emitted the same type of vocalizations just after the stimulus playbacks, and similar regularities were observed in the temporal intervals of phees and in trills. they vocalized with shorter intervals when they responded with trills rather than phees, and, after the first call, ... | 2009 | 19396872 |
| zonisamide increases dopamine turnover in the striatum of mice and common marmosets treated with mptp. | the effect of zonisamide, an antiepileptic agent with anti-parkinsonian effects, was studied on dopamine neurons of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-treated c57 mice and common marmosets. groups of mice (n = 8 - 9) were treated with: mptp (15 mg/kg every 2 h x4); mptp plus zonisamide (40 mg/kg administered 1 h before each mptp dose); mptp plus selegiline (2 mg/kg administered 1 h before the first mptp dose); zonisamide (40 mg/kg x4); and saline controls. groups of common marmo ... | 2009 | 19403994 |
| web-accessible digital brain atlas of the common marmoset (callithrix jacchus). | here we describe a web-accessible digital brain atlas of the common marmoset (callithrix jacchus) at http://marmoset-brain.org:2008. we prepared the histological sections of the marmoset brain using various staining techniques. for virtual microscopy, high-resolution digital images of sections were obtained with aperio scanscope. the digital images were then converted to zoomify files (zoomable multiresolution image files). thereby, we could provide the multiresolution images of the marmoset bra ... | 2009 | 19428691 |
| lack of adaptation of chimeric gb virus b/hepatitis c virus in the marmoset model: possible effects of bottleneck. | approximately 3% of the world population is chronically infected with hepatitis c virus (hcv). gb virus b (gbv-b), a surrogate model for hcv, causes hepatitis in tamarins and is the virus phylogenetically most closely related to hcv. previously we described a chimeric gbv-b containing an hcv insert from the 5' noncoding region (ncr) that was adapted for efficient replication in tamarins (saguinus species). we have also demonstrated that wild-type (wt) gbv-b rapidly adapts for efficient replicati ... | 2009 | 19474092 |
| generation of transgenic non-human primates with germline transmission. | the common marmoset (callithrix jacchus) is increasingly attractive for use as a non-human primate animal model in biomedical research. it has a relatively high reproduction rate for a primate, making it potentially suitable for transgenic modification. although several attempts have been made to produce non-human transgenic primates, transgene expression in the somatic tissues of live infants has not been demonstrated by objective analyses such as polymerase chain reaction with reverse transcri ... | 2009 | 19478777 |
| cd73, a novel cell surface antigen that characterizes retinal photoreceptor precursor cells. | the authors sought to identify cell surface markers of photoreceptor and its precursor cells. | 2009 | 19515998 |
| growth characteristics of the nonhuman primate embryonic stem cell line cjes001 depending on feeder cell treatment. | embryonic stem cells (esc) hold tremendous potential for therapeutic applications, including regenerative medicine, as well as for understanding basic mechanisms in stem cell biology. since numerous experiments cannot be conducted in human esc because of ethical or practical limitations, nonhuman primate esc serve as invaluable clinically relevant models. the novel marmoset (callithrix jacchus) esc line cjes001 was characterized using different stem cell markers. the cells were stained positivel ... | 2009 | 19522672 |
| spontaneous pathology of the common marmoset (callithrix jacchus) and tamarins (saguinus oedipus, saguinus mystax). | marmosets and tamarins are increasingly used in research, but their pathology remains poorly defined compared with old world primates. | 2009 | 19522731 |
| distribution of vasopressin and oxytocin binding sites in the brain and upper spinal cord of the common marmoset. | the aim of this study was to label selectively and to map central vasopressin (avp) and oxytocin (ot) binding sites in the common marmoset. [(125)i]vpa, a compound selective in rodents and human for the avp v(1a) receptor, yielded the same labeling pattern as [(3)h]avp, thus suggesting that most avp receptors present in the marmoset brain are of the v(1a) subtype. numerous areas exhibited avp binding sites, among which the olfactory bulb, the accumbens nucleus, the bed nucleus of the stria termi ... | 2009 | 19539696 |
| a new world primate deficient in tetherin-mediated restriction of human immunodeficiency virus type 1. | human immunodeficiency virus type 1 (hiv-1) does not replicate in primary cells of new world primates. to better understand this restriction, we expressed owl monkey (aotus nancymaae) cd4 and cxcr4 in the owl monkey kidney cell line, omk. an hiv-1 variant modified to evade the owl monkey restriction factor trim-cyp replicated efficiently in these cells but could not replicate in primary a. nancymaae cd4-positive t cells. to understand this difference, we examined apobec3g and tetherin orthologs ... | 2009 | 19553332 |
| antiphonal call timing in marmosets is behaviorally significant: interactive playback experiments. | studies of primate vocal communication systems have generally focused on vocalizations and the information they convey to conspecifics. but the vocalizations are not the only sources of information. aspects of each species vocal behaviors are likely to be communicatively rich as well. during vocal interactions, for example, the latency delay between the calls could communicate an important message to the signal receiver, such as an interest and willingness to socialize. here we employed novel, i ... | 2009 | 19597736 |
| continuous administration of rotigotine to mptp-treated common marmosets enhances anti-parkinsonian activity and reduces dyskinesia induction. | rotigotine is a novel, non-ergoline dopamine d(3)/d(2)/d(1)-receptor agonist for the treatment of parkinson's disease that can be continuously delivered by the transdermal route to provide stable plasma levels. continuous drug delivery should reduce the risk of dyskinesia induction in comparison to pulsatile dopaminergic treatment. thus the aim of the study was to compare the reversal of motor disability and induction of dyskinesia produced by continuous compared to pulsatile rotigotine administ ... | 2009 | 19619533 |
| development of microsatellite dna markers and their chromosome assignment in the common marmoset. | this study was performed to develop microsatellite dna markers, which are useful for linkage analyses, gene mapping and blood chimera analyses in the common marmoset (callithrix jacchus). we searched 153 of 295 bacterial artificial clone dna sequences of the common marmoset that were archived in the ncbi database in 2004. on the basis of the search, we designed 186 pcr primer sets. when tested using 5 unrelated individuals, we successfully detected 154 markers with pcr products, of which 80 (52% ... | 2009 | 19637280 |
| effect of nest box availability on the circadian activity rhythm of common marmosets (callithrix jacchus). | the effect of nest box availability on the circadian activity rhythm (car) was compared in a diurnal primate kept in two conditions: with and without nest box, in a light-dark (ld) cycle (12:12) and constant light (ll). marmosets kept in ld without nest box showed a longer duration of the activity phase (alpha), smaller day-to-day variability in activity onset and offset and higher levels of activity, particularly towards the end of the activity time. in ll, all animals maintained with nest box ... | 2009 | 19641323 |
| new developmental stages for common marmosets (callithrix jacchus) using mass and age variables obtained by k-means algorithm and self-organizing maps (som). | this study proposes new developmental stages for callithrix jacchus, using k-means algorithm and an artificial neural network-self-organising maps (som) as computational tools, based on weight and age. eight developmental stages are proposed: infant i, ii and iii, juvenile i and ii, sub adult, young adult and older adult. this classification is consistent with the first appearance of several behavioural and physiological characteristics and thus may have generality in defining critical developme ... | 2009 | 19651403 |
| connections of the marmoset rostrotemporal auditory area: express pathways for analysis of affective content in hearing. | the current hierarchical model of primate auditory cortical processing proposes a core of 'primary-like' areas, which is surrounded by secondary (belt) and tertiary (parabelt) regions. the rostrotemporal auditory cortical area (rt) remains the least well characterized of the three proposed core areas, and its functional organization has only recently come under scrutiny. here we used injections of anterograde and retrograde tracers in the common marmoset (callithrix jacchus) to examine the conne ... | 2009 | 19663937 |
| prolactin's mediative role in male parenting in parentally experienced marmosets (callithrix jacchus). | prolactin has been implicated in promoting paternal care behaviors but little evidence of causality has been found to date except for birds and fish. this study was designed to examine the possible causal relationships between prolactin and male parenting behaviors, reproductive hormones, and physical changes in cooperatively breeding common marmosets, callithrix jacchus. fifteen parentally experienced fathers were studied over three consecutive infant care periods during two weeks prior and thr ... | 2009 | 19664636 |
| stereo navi 2.0: software for stereotaxic surgery of the common marmoset (callithrix jacchus). | recently, we reported our web-accessible digital brain atlas of the common marmoset (callithrix jacchus) at http://marmoset-brain.org:2008. using digital images obtained during construction of this website, we developed stand-alone software for navigation of electrodes or injection needles for stereotaxic electrophysiological or anatomical experiments in vivo. this software enables us to draw lines on exchangeable section images, measure the length and angle of lines, superimpose a stereotaxic r ... | 2009 | 19682507 |
| cooperatively breeding cottontop tamarins (saguinus oedipus) do not donate rewards to their long-term mates. | this study tested the hypothesis that cooperative breeding facilitates the emergence of prosocial behavior by presenting cottontop tamarins (saguinus oedipus) with the option to provide food rewards to pair-bonded mates. in experiment 1, tamarins could provide rewards to mates at no additional cost while obtaining rewards for themselves. contrary to the hypothesis, tamarins did not demonstrate a preference to donate rewards, behaving similar to chimpanzees in previous studies. in experiment 2, t ... | 2009 | 19685964 |
| development of monoclonal antibodies for analyzing immune and hematopoietic systems of common marmoset. | common marmosets are considered experimental animals of primates useful for medical research. we developed several monoclonal antibodies (mabs) directed to cd molecules to gain initial insight into the immune and hematopoietic systems of this organism, and analyzed the basic cellularity and characters of marmoset lymphocytes. | 2009 | 19715740 |
| prenatal programming of metabolic syndrome in the common marmoset is associated with increased expression of 11beta-hydroxysteroid dehydrogenase type 1. | recent studies in humans and animal models of obesity have shown increased adipose tissue activity of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-hsd1), which amplifies local tissue glucocorticoid concentrations. the reasons for this 11beta-hsd1 dysregulation are unknown. here, we tested whether 11beta-hsd1 expression, like the metabolic syndrome, is "programmed" by prenatal environmental events in a nonhuman primate model, the common marmoset monkey. | 2009 | 19720800 |
| digestion in the common marmoset (callithrix jacchus), a gummivore-frugivore. | wild common marmosets (callithrix jacchus) feed on fruits, insects, and gums, all of which provide different digestive challenges. much of the ingested mass of fruits consists of seeds. in general, seeds represent indigestible bulk to marmosets and could inhibit feeding if they are not eliminated rapidly. in contrast, gums are beta-linked polysaccharides that require microbial fermentation. their digestion would benefit from an extended residence time within the gut. earlier research found that ... | 2009 | 19725117 |
| evolutionary trajectories of primate genes involved in hiv pathogenesis. | the current availability of five complete genomes of different primate species allows the analysis of genetic divergence over the last 40 million years of evolution. we hypothesized that the interspecies differences observed in susceptibility to hiv-1 would be influenced by the long-range selective pressures on host genes associated with hiv-1 pathogenesis. we established a list of human genes (n = 140) proposed to be involved in hiv-1 biology and pathogenesis and a control set of 100 random gen ... | 2009 | 19726537 |
| a monoclonal antibody selection for immunohistochemical examination of lymphoid tissues from non-human primates. | non-human primates (nhps) offer valuable animal models for basic research into human diseases and for the preclinical validation of new therapeutics. detailed in situ examination of the involved cell types using immunohistochemistry is often hampered by the lack of cross-reactive antibodies (abs). in the current study, we have tested a large panel of monoclonal antibodies raised against human leukocyte differentiation and activation markers for cross-reactivity on cryosections of lymphoid tissue ... | 2009 | 19729671 |
| rapidly evolving marmoset msmb genes are differently expressed in the male genital tract. | beta-microseminoprotein, an abundant component in prostatic fluid, is encoded by the potential tumor suppressor gene msmb. some new world monkeys carry several copies of this gene, in contrast to most mammals, including humans, which have one only. here we have investigated the background for the species difference by analyzing the chromosomal organization and expression of msmb in the common marmoset (callithrix jacchus). | 2009 | 19737427 |
| visualizing the entire cortical myelination pattern in marmosets with magnetic resonance imaging. | myeloarchitecture, the pattern of myelin density across the cerebral cortex, has long been visualized in histological sections to identify distinct anatomical areas of the cortex. in humans, two-dimensional (2d) magnetic resonance imaging (mri) has been used to visualize myeloarchitecture in select areas of the cortex, such as the stripe of gennari in the primary visual cortex and heschl's gyrus in the primary auditory cortex. here, we investigated the use of mri contrast based on longitudinal r ... | 2009 | 19737577 |
| transplantation of dendritic cells promotes functional recovery from spinal cord injury in common marmoset. | we previously reported that implantation of dendritic cells (dcs) into the injured site activates neural stem/progenitor cells (nspcs) and promotes functional recovery after spinal cord injury (sci) in mice. working toward clinical application of dc therapy for sci, we analyzed whether dcs promote functional recovery after sci in a non-human primate, the common marmoset (cm). cms are usually born as dizygotic twins. they are thus natural bone marrow and peripheral blood chimeras due to sharing o ... | 2009 | 19737583 |
| placental insulin-like growth factor ii (igf-ii) and its relation to litter size in the common marmoset monkey (callithrix jacchus). | the primate placenta produces a wide variety of hormones throughout gestation that regulate placental function and fetal growth. one such hormone is insulin-like growth factor-ii (igf-ii), a peptide implicated in cell division, differentiation, and amino acid transport. igf-ii concentrations were measured in 23 common marmoset (callithrix jacchus) term placentas from twin and triplet litters in order to determine whether previously described differences in fetoplacental phenotype such as placent ... | 2009 | 19743442 |
| a combined histological and mri brain atlas of the common marmoset monkey, callithrix jacchus. | the common marmoset, callithrix jacchus, is of growing importance for research in neuroscience and related fields. in the present work, we describe a combined histological and magnetic resonance imaging (mri) atlas constructed from the brains of two adult female marmosets. histological sections were processed from nissl staining and digitized to produce an atlas in a large format that facilitates visualization of structures with significant detail. naming of identifiable brain structures was per ... | 2009 | 19744521 |
| expression of catechol-o-methyltransferase in the brain and periphery of normal and mptp-treated common marmosets. | catechol-o-methyltransferase (comt) inhibition is widely used to potentiate the effects of levodopa in parkinson's disease but the effects of nigral dopaminergic cell loss and levodopa treatment on comt activity are not known. the present study investigated the expression of comt in the brain and liver of normal common marmosets, and animals treated with mptp and those treated with levodopa to induce dyskinesia. reverse transcript pcr demonstrated the expression of comt mrna in the liver, cortex ... | 2010 | 19771390 |
| permanent or transient chronic ischemic stroke in the non-human primate: behavioral, neuroimaging, histological, and immunohistochemical investigations. | using multimodal magnetic resonance imaging (mri), behavioral, and immunohistochemical analyses, we examined pathological changes at the acute, sub-acute, and chronic stages, induced by permanent or temporary ischemia in the common marmoset. animals underwent either permanent (pmcao) or 3-h transient (tmcao) occlusion of the middle cerebral artery (mcao) by the intraluminal thread approach. mri scans were performed at 1 h, 8, and 45 days after mcao. sensorimotor deficits were assessed weekly up ... | 2010 | 19794396 |
| non-human primate model of kaposi's sarcoma-associated herpesvirus infection. | since kaposi's sarcoma-associated herpesvirus (kshv or human herpesvirus 8) was first identified in kaposi's sarcoma (ks) lesions of hiv-infected individuals with aids, the basic biological understanding of kshv has progressed remarkably. however, the absence of a proper animal model for kshv continues to impede direct in vivo studies of viral replication, persistence, and pathogenesis. in response to this need for an animal model of kshv infection, we have explored whether common marmosets can ... | 2009 | 19798430 |
| human neural stem cells ameliorate autoimmune encephalomyelitis in non-human primates. | transplanted neural stem/precursor cells (npcs) display peculiar therapeutic plasticity in vivo. although the replacement of cells was first expected as the prime therapeutic mechanism of stem cells in regenerative medicine, it is now clear that transplanted npcs simultaneously instruct several therapeutic mechanisms, among which replacement of cells might not necessarily prevail. a comprehensive understanding of the mechanism(s) by which npcs exert their therapeutic plasticity is lacking. this ... | 2009 | 19798728 |
| gene expression profiles in the common marmoset brain determined using a newly developed common marmoset-specific dna microarray. | to facilitate common marmoset brain research, we produced a dna microarray with 7557 probe sets derived from the common marmoset brain. gene expression profiles in the frontal lobe, hippocampus, cerebellum and amygdaloid nucleus were then analyzed and the top 100 probe sets expressed in each structure were compared. the three lists for the frontal lobe, hippocampus and amygdaloid nucleus were very similar but the probe sets for the cerebellum demonstrated specific differences. some of the genes ... | 2010 | 19808062 |
| the dopamine d(2) receptor partial agonist aplindore improves motor deficits in mptp-treated common marmosets alone and combined with l-dopa. | dopamine replacement therapy in parkinson's disease (pd) using l-dopa is invariably associated with a loss of drug efficacy ("wearing off") and the onset of dyskinesia. the use of dopamine receptor partial agonists might improve therapeutic benefit without increased dyskinesia expression but may antagonise the effects of l-dopa. we now examine the effects of the novel high affinity, dopamine d(2) receptor partial agonist, aplindore alone and in combination with l-dopa in the 1-methyl-4-phenyl-1, ... | 2010 | 19809864 |
| experimental autoimmune encephalomyelitis in the common marmoset, a bridge between rodent eae and multiple sclerosis for immunotherapy development. | the attrition rate of new drugs for central nervous system diseases including multiple sclerosis (ms) is very high. a widely recognized bottleneck in the selection of promising central nervous system drug candidates from the development pipeline is the lack of sufficiently predictive animal models. here, we review how the experimental autoimmune encephalomyelitis (eae) model in the neotropical primate "common marmoset" can help to bridge the gap between rodent eae models and ms. the eae model in ... | 2010 | 19826959 |
| synaptic inputs onto small bistratified (blue-on/yellow-off) ganglion cells in marmoset retina. | the inner plexiform layer of the retina contains functional subdivisions, which segregate on and off type light responses. here, we studied quantitatively the on and off synaptic input to small bistratified (blue-on/yellow-off) ganglion cells in marmosets (callithrix jacchus). small bistratified cells display an extensive inner dendritic tier that receives blue-on input from short-wavelength-sensitive (s) cones via blue cone bipolar cells. the outer dendritic tier is sparse and is thought to rec ... | 2009 | 19830807 |
| continuous rotigotine administration reduces dyskinesia resulting from pulsatile treatment with rotigotine or l-dopa in mptp-treated common marmosets. | we previously showed that continuous infusion of rotigotine resulted in less dyskinesia than repeated pulsatile rotigotine administration or repeated oral administration of l-dopa in mptp-treated marmosets. now we investigate whether continuous rotigotine delivery modifies established dyskinesia induced by prior exposure to repeated pulsatile administration of l-dopa or rotigotine in mptp-treated common marmosets. repeated oral administration of l-dopa or subcutaneous bolus administration of rot ... | 2010 | 19833125 |
| trabecular bone structure in the mandibular condyles of gouging and nongouging platyrrhine primates. | the relationship between mandibular form and biomechanical function is a topic of significant interest to morphologists and paleontologists alike. several previous studies have examined the morphology of the mandible in gouging and nongouging primates as a means of understanding the anatomical correlates of this feeding behavior. the goal of the current study was to quantify the trabecular bone structure of the mandibular condyle of gouging and nongouging primates to assess the functional morpho ... | 2010 | 19918988 |
| propagation and characterisation of dendritic cells from g-csf mobilised peripheral blood monocytes and stem cells in common marmoset monkeys. | the common marmoset is a small new world primate that has been used as an immunological model for a number of human diseases. dendritic cells (dc) have not been extensively characterised in this species and in particular protocols to derive dc from living donors without the need for animal sacrifice are presently lacking. this study establishes new protocols to generate substantial numbers of marmoset dc for use in cell therapy studies. recombinant human g-csf was used to mobilise peripheral blo ... | 2010 | 19931270 |
| the morphology of the masticatory apparatus facilitates muscle force production at wide jaw gapes in tree-gouging common marmosets (callithrix jacchus). | common marmosets (callithrix jacchus) generate wide jaw gapes when gouging trees with their anterior teeth to elicit tree exudate flow. closely related cotton-top tamarins (saguinus oedipus) do not gouge trees but share similar diets including exudates. maximizing jaw opening theoretically compromises the bite forces that marmosets can generate during gouging. to investigate how jaw-muscle architecture and craniofacial position impact muscle performance during gouging, we combine skull and jaw-m ... | 2009 | 19946083 |
| bone mineral analysis through dual energy x-ray absorptiometry in laboratory animals. | to determine how to eliminate species difference in animal bone experiment, bone mineral content (bmc) was measured using dual energy x-ray absorptiometry (dxa) on the femurs of laboratory mice (mus musculus) and rats (rattus norvegicus), and common marmosets (callithrix jacchus). measures were taken on femurs in situ, detached from the body, skinned and defleshed, or dried completely. when the bmc of the bone measured in the intact limb attached to the trunk was set at 100%, the actual bmc of t ... | 2009 | 19959901 |
| immunotoxicity testing in nonhuman primates. | biological relevance is generally the major justification for using nonhuman primates (nhp) during preclinical safety assessment. this holds particularly true for the evaluation of biopharmaceuticals with nhp often being the species of choice. for safety assessment of small molecules, nhp are used in case of a higher degree of metabolic similarity, to detect the highly specific immunotoxic side effects and to discriminate toxicity from efficacy of immunomodulatory drugs. unlike for rodent immuno ... | 2010 | 19967524 |
| preimplantation development of somatic cell cloned embryos in the common marmoset (callithrix jacchus). | the somatic cell nuclear transfer technique has been applied to various mammals to produce cloned animals; however, a standardized method is not applicable to all species. we aimed here to develop optimum procedures for somatic cell cloning in nonhuman primates, using common marmosets. first, we confirmed that parthenogenetic activation of in vitro matured oocytes was successfully induced by electrical stimulation (three cycles of 150 v/mm, 50 microsec x 2, 20 min intervals), and this condition ... | 2009 | 20025525 |
| within-session changes in licking as a function of sucrose concentration in common marmosets. | common marmosets (callithrix jacchus) were allowed to lick sucrose solutions freely in 30-min sessions. we examined how the rate of licking changed in the course of a session and how the pattern of changes was affected by different concentrations (1%, 5%, and 25%) of solutions. the results showed that licking rates decreased monotonically regardless of the concentrations and that the decreasing patterns could be reasonably explained by exponential functions. the rates of decrease were slowest fo ... | 2010 | 20035844 |
| perception of biological motion in common marmosets (callithrix jacchus): by females only. | the ability to perceive biological motion (bm) has been demonstrated in a number of species including humans but the few studies of non-human primates have been relatively inconclusive. we investigated whether common marmosets (callithrix jacchus) are able to perceive biological motion, using a novel method to test non-human primates. marmosets (7 male and 7 female) were trained to remove a cover from a container and look inside it, revealing a computer screen. then they were presented with imag ... | 2010 | 20052512 |
| the relationship between the production and the anti-gonadotrophic action of prostaglandin f 2 alpha in luteal cells from the marmoset monkey (callithrix jacchus) in the early and mid-luteal phase. | to address the potential luteolytic role for prostaglandin f(2 alpha) (pgf(2 alpha)) in the corpus luteum of the common marmoset monkey (callithrix jacchus), the ability of marmoset luteal cells, maintained in monolayer culture, to produce pgf(2 alpha) was determined in vitro in the presence and absence of human chorionic gonadotrophin (hcg) and other established pharmacological modulators of pgf(2 alpha) synthesis. we also assessed the effects of the pgf(2 alpha) analogue, cloprostenol, on prog ... | 2010 | 20067799 |
| transplantation of galectin-1-expressing human neural stem cells into the injured spinal cord of adult common marmosets. | delayed transplantation of neural stem/progenitor cells (ns/pcs) into the injured spinal cord can promote functional recovery in adult rats and monkeys. to enhance the functional recovery after ns/pc transplantation, we focused on galectin-1, a carbohydrate-binding protein with pleiotropic roles in cell growth, differentiation, apoptosis, and neurite outgrowth. here, to determine the combined therapeutic effect of ns/pc transplantation and galectin-1 on spinal cord injury (sci), human ns/pcs wer ... | 2010 | 20091712 |
| application of probabilistic analysis for precisely correcting the qt interval for heart rate in telemetered common marmosets. | qt intervals are strongly influenced by preceeding heart rate history and are also characterized by rate-independent variability, leading to difficulty in precise rate-correction of the raw qt interval. the present study elucidates a novel analytical method that effectively addresses this problematic phenomenon in telemetered common marmosets. | 2010 | 20097297 |
| sensitivity of common marmosets to detect drug-induced qt interval prolongation: moxifloxacin case study. | moxifloxacin is the most widely used positive reference agent in clinical cardiac repolarization studies, but it has not been characterized in common marmosets which are uniquely suited to studies in early-stage development due to their small size and minimal test article requirements. the purpose of this study was to evaluate the sensitivity of the common marmoset to detect moxifloxacin-associated qt interval prolongation. | 2014 | 20097298 |
| pramipexole combined with levodopa improves motor function but reduces dyskinesia in mptp-treated common marmosets. | reduced expression of dyskinesia is observed in levodopa-primed mptp-treated common marmosets when dopamine agonists are used to replace levodopa. we now investigate whether a combination of the d-2/d-3 agonist pramipexole and levodopa also reduces dyskinesia intensity while maintaining the reversal of motor disability. drug naïve, non-dyskinetic mptp-treated common marmosets were treated daily for up to 62 days with levodopa (12.5 mg/kg plus carbidopa 12.5 mg/kg p.o. bid) or pramipexole (0.04-0 ... | 2010 | 20108359 |
| species-specific inhibition of foamy viruses from south american monkeys by new world monkey trim5{alpha} proteins. | foamy virus evolution closely parallels that of the host species, indicating virus-host coadaptation. we studied simian foamy viruses (sfvs) from common marmosets, spider monkeys, and squirrel monkeys, new world monkey (nwm) species that share geographic ranges. the trim5alpha protein from each of these nwm species inhibited the replication of at least one of the sfvs associated with the other two species but did not affect the replication of its own sfv. thus, trim5alpha has potentially shaped ... | 2010 | 20130055 |
| neighbor effects in marmosets: social contagion of agonism and affiliation in captive callithrix jacchus. | researchers have demonstrated the neighbor effect for affiliative and agonistic neighbor vocalizations in captive chimpanzees. we extend the investigation of the neighbor effect to new world monkeys, callithrix jacchus. we collected data on vocalizations and behaviors of 31 focal individuals and concurrent neighbor vocalization within three behavioral categories: intragroup and intergroup aggression and intragroup affiliation. we investigated whether there was an influence of neighbor vocalizati ... | 2010 | 20131362 |
| primate early life stress leads to long-term mild hippocampal decreases in corticosteroid receptor expression. | expression of mineralocorticoid receptor (mr) and glucocorticoid receptor (gr) genes are moderately reduced in several brain regions in depression. these reductions could be partly due to early life stress (els), which predicts emotional disorders. controlled primate studies are important to test whether els sufficient to induce long-term emotional changes also induces long-term altered mr and/or gr brain expression. | 2010 | 20132928 |
| protection by pyridostigmine bromide of marmoset hemi-diaphragm acetylcholinesterase activity after soman exposure. | pyridostigmine bromide (pb) was approved by the u.s. food and drug administration (fda) in 2003 as a pretreatment in humans against the lethal effects of the irreversible nerve agent soman (gd). organophosphate (op) chemical warfare agents such as gd exert their toxic effects by inhibiting acetylcholinesterase (ache) from terminating the action of acetylcholine at postsynaptic sites in cholinergic nerve terminals (including crucial peripheral muscle such as diaphragm). as part of the post-market ... | 2010 | 20144889 |
| neural coding of periodicity in marmoset auditory cortex. | pitch, our perception of how high or low a sound is on a musical scale, crucially depends on a sound's periodicity. if an acoustic signal is temporally jittered so that it becomes aperiodic, the pitch will no longer be perceivable even though other acoustical features that normally covary with pitch are unchanged. previous electrophysiological studies investigating pitch have typically used only periodic acoustic stimuli, and as such these studies cannot distinguish between a neural representati ... | 2010 | 20147419 |
| luteotrophic effects of relaxin, chorionic gonadotrophin and fsh in common marmoset monkeys (callithrix jacchus). | in early pregnant primates, relaxin (rlx) is highly upregulated within the corpus luteum (cl), suggesting that rlx may have an important role in the implantation of the blastocyst. therefore, the aim of the present study was to investigate the local effects of rlx and gonadotrophins on the maintenance of the cl using an in vitro microdialysis system. cls of common marmoset monkeys were collected by luteectomy during different stages of the luteal phase and early pregnancy. each cl was perfused w ... | 2010 | 20156883 |
| performance of juvenile baboons on neuropsychological tests assessing associative learning, motivation and attention. | the cantab (cambridge neuropsychological test automated battery), a system developed for human neuropsychological testing, has previously been used to assess cognitive function in two species of nonhuman primates, common marmoset monkeys and rhesus macaques. we describe the application of the system to the juvenile baboon, a nonhuman primate species offering specific investigative advantages. juvenile baboons were trained and tested on a progressive ratio task to assess motivation, simple discri ... | 2010 | 20170676 |
| retinal afferents synapse with relay cells targeting the middle temporal area in the pulvinar and lateral geniculate nuclei. | considerable debate continues regarding thalamic inputs to the middle temporal area (mt) of the visual cortex that bypass the primary visual cortex (v1) and the role they might have in the residual visual capability following a lesion of v1. two specific retinothalamic projections to area mt have been speculated to relay through the medial portion of the inferior pulvinar nucleus (pim) and the koniocellular layers of the dorsal lateral geniculate nucleus (lgn). although a number of studies have ... | 2010 | 20179789 |
| severe intragroup aggressions in captive common marmosets (callithrix jacchus). | members of captive colonies of common marmosets (callithrix jacchus), a small new world primate, can occasionally be victims of repeated, and potentially fatal, attacks by a family-mate. this study examined the records of a colony, looking for past instances of such aggressions. the aim was to better understand the possible causes underlying this phenomenon and to identify variables that could minimize their occurrence. the results showed that both males and females behaved as aggressors at the ... | 2009 | 20183475 |
| efficient gene transfer into neurons in monkey brain by adeno-associated virus 8. | although the adeno-associated virus (aav) vector is a promising tool for gene transfer into neurons, especially for therapeutic purposes, neurotropism in primate brains is not fully elucidated for specific aav serotypes. here, we injected aav serotype 8 (aav8) vector carrying the enhanced green fluorescent protein (egfp) gene under a ubiquitous promoter into the cerebral cortex, striatum and substantia nigra of common marmosets. robust neuronal egfp expression was observed at all injected sites. ... | 2010 | 20224455 |
| neuronal mhc class i molecules are involved in excitatory synaptic transmission at the hippocampal mossy fiber synapses of marmoset monkeys. | several recent studies suggested a role for neuronal major histocompatibility complex class i (mhci) molecules in certain forms of synaptic plasticity in the hippocampus of rodents. here, we report for the first time on the expression pattern and functional properties of mhci molecules in the hippocampus of a nonhuman primate, the common marmoset monkey (callithrix jacchus). we detected a presynaptic, mossy fiber-specific localization of mhci proteins within the marmoset hippocampus. mhci molecu ... | 2010 | 20232136 |
| time course of vocal modulation during isolation in common marmosets (callithrix jacchus). | common marmosets vocalize phee calls as isolation calls, which seem to facilitate their reunion with family groups. to identify multiple acoustic properties with different time courses, we examined acoustic modulations of phees during different social contexts of isolation. subject marmosets were totally isolated in one condition, were visually isolated and could exchange vocalizations in another condition, and were visually isolated and subsequently totally isolated in a third condition. we rec ... | 2010 | 20301139 |
| the timing of administration, dose dependence and efficacy of dopa decarboxylase inhibitors on the reversal of motor disability produced by l-dopa in the mptp-treated common marmoset. | dopa decarboxylase inhibitors are routinely used to potentiate the effects of l-dopa in the treatment of parkinson's disease. however, neither in clinical use nor in experimental models of parkinson's disease have the timing and dose of dopa decarboxylase inhibitors been thoroughly explored. we now report on the choice of dopa decarboxylase inhibitors, dose and the time of dosing relationships of carbidopa, benserazide and l-alpha-methyl dopa (l-amd) in potentiating the effects of l-dopa in the ... | 2010 | 20303948 |
| effects of antenatal dexamethasone treatment on glucocorticoid receptor and calcyon gene expression in the prefrontal cortex of neonatal and adult common marmoset monkeys. | synthetic glucocorticoids such as dexamethasone (dex) are commonly used to promote fetal lung maturation in at-risk preterm births, but there is emerging evidence of subsequent neurobehavioral abnormalities in these children e.g. problems with inattention/hyperactivity. however, molecular pathways mediating effects of glucocorticoid overexposure on motor and cognitive development are poorly understood. | 2010 | 20307270 |
| maternal care and infant development in callimico goeldii and callithrix jacchus. | callimico goeldii gives birth to single offspring, whereas other callitrichids, including callithrix jacchus, twin. this study compares maternal effort and infant development in c. goeldii and c. jacchus; it is the first study to look at nursing frequency. infants were observed from birth for 7 weeks in two captive groups each of c. goeldii and c. jacchus. c. goeldii mothers physiologically invested the same or less than c. jacchus mothers. c. goeldii mothers gained the same amount of weight dur ... | 2010 | 20339900 |
| mapping of serotonin transporters by positron emission tomography with [11c]dasb in conscious common marmosets: comparison with rhesus monkeys. | the common marmoset (callithrix jacchus) is unique among the primates in its small body size, reproductive efficacy, and characteristic social behavior, making it useful as an animal model in neuroscientific research. to assess the brain serotonergic systems, we investigated the binding of [(11)c]-3-amino-4-(2-dimetylaminomethyl-phenylsulfanyl)-benzonitrile ([(11)c]dasb) to brain serotonin transporter (sert) in conscious common marmosets using positron emission tomography (pet), and compared wit ... | 2010 | 20340166 |
| autonomic, behavioral, and neural analyses of mild conditioned negative affect in marmosets. | avoidance and alerting behaviors and accompanying physiological responses, including changes in heart rate (hr), are core components of negative emotion. investigations into the neural mechanisms underlying the regulation and integration of these responses require animal models that simultaneously measure both the physiological and behavioral components of emotion. a primate model is of particular importance in view of the well developed prefrontal cortex of primates, and this region's critical ... | 2010 | 20364879 |
| helminths found in marmosets (callithrix penicillata and callithrixjacchus) introduced to the region of occurrence of golden lion tamarins (leontopithecusrosalia) in brazil. | the introduction of exotic species can increase the risk of extinction of native species through the introduction of new diseases, predation or resource competition. the marmosets callithrix penicillata and callithrix jacchus and hybrids of these two species have been introduced to privately owned forests in the lowland atlantic forest of the rio de janeiro state in brazil, the region of occurrence of the endangered golden lion tamarin, leontopithecus rosalia. because the ecology and biology of ... | 2010 | 20378249 |