Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| activated partial thromboplastin time after heparin removal (aptt/hr) in a new scheme of anticoagulant monitoring. | activated partial thromboplastin time after heparin removal (aptt/hr), a test employing anion exchange chromatography, was devised as an alternative to the prothrombin time after heparin removal (pt/hr) to monitor simultaneous anticoagulation with heparin and coumarins. the potential utility of the aptt/hr was assessed by performing parallel pts and aptts on 62 consecutive plasmas from coumarin-treated outpatients. all samples had 0.2 units/ml of heparin added and then removed to see if the mane ... | 1982 | 7114053 |
| central nervous system lesions in fisher syndrome: report of a case with ct findings. | 1982 | 7130734 | |
| first person account: maintaining mental health in a turbulent world. | the article and the poems that follow are part of the schizophrenia bulletin's ongoing first person accounts series. we hope that mental health professionals--the bulletin's primary audience--will take this opportunity to learn about the issues and difficulties confronted by consumers of mental health care. in addition, we hope that these accounts will give patients and families a better sense of not being alone in confronting the problems that can be anticipated by persons with serious emotiona ... | 1982 | 7134897 |
| the diagnostic value of measuring creatine kinase bb activity in cerebrospinal fluid following acute head injury. | during a period of 2 months the activity of creatine kinase bb (ck-bb) was measured in the cerebrospinal fluid (csf) from 93 consecutive patients admitted as emergencies to the neurosurgical department. fourteen of the 15 patients with verified brain contusion showed an increased activity of ck-bb in the csf whereas all patients with various other acute neurological disorders, such as epilepsy and acute headache, had a normal ck-bb activity. two of 5 patients with subarachnoidal haemorrhage and ... | 1982 | 7136881 |
| intracranial delivery of metrizamide from the lumbar subarachnoid space: prone versus supine positioning. | forty patients undergoing metrizamide computed tomographic cisternography (mctc) were prospectively evaluated for the relative merits of prone and supine positioning for the intracranial delivery of the subarachnoid contrast material. twenty patients were prone and 20 supine when tilted head downward. the degree of opacification was deemed satisfactory or unsatisfactory in each case for the various ventricles and for the suprasellar, quadrigeminal, perimesencephalic, and cerebellopontine angle c ... | 1982 | 7142507 |
| cigarette smoking and lung cancer: a continuing controversy. | during the late 1950s sir ronald fisher questioned the already popular, but in his view precipitate, causal interpretation of the association between smoking and lung cancer. his pungently expressed views began a controversy that has smouldered and sometimes flared ever since. the most recent attack on fisher's constitutional hypothesis was launched by reif and in this paper i consider the validity of his criticisms. a range of evidence shows that it is not yet possible to distinguish between co ... | 1982 | 7144635 |
| allele frequencies in a multidimensional wright-fisher model with general mutation. | a formula is obtained for the probability that two genes at a single locus, sampled at random from a population at time t, are of particular types. the model assumed is a diffusion approximation to a neutral wright-fisher model in which mutation is general and not necessarily symmetric. an example is given of a population in which one allele has a high mutation rate, and the others have an equal, low mutation rate. the matrix q, with elements given by the probability of sampling two alleles of p ... | 1982 | 7153670 |
| lymphocyte reactivity to crohn's ileal homogenates. | this study was undertaken to demonstrate whether lymphocytes derived from patients with crohn's disease and their household contacts would demonstrate increased reactivity upon exposure to tissue homogenates prepared from the terminal ileum of patients with crohn's disease. it was demonstrated that 4 of 18 patients, 9 of 30 household contacts, and 0 of 13 control subjects exhibited statistically greater lymphocyte thymidine incorporation in response to crohn's tissue homogenates (contacts vs con ... | 1982 | 7154058 |
| [miller fisher syndrome. report of a case]. | the case of a man 34 year-old presenting upward gaze paralyses and external ophthalmoplegia without involvement of the downward gaze, accompanied by cerebellar disorders, generalized areflexia but no muscular weakness, and moderate sensory impairment of the four extremities is reported. the cerebrospinal fluid showed an albuminocytologic dissociation. recovery was rapid and almost complete, within 3 weeks, remaining minimal paresis of the upward gaze and lateral movement in both eyes. the improv ... | 1982 | 7159257 |
| levels of lipid peroxidation in hepatocytes isolated from aging rats fed an antioxidant-free diet. | enzymatically isolated hepatocytes were utilized to evaluate levels of lipid peroxidation in young (3 months), adult (12 months) and aged (25 months) fisher-344 female rats. lipid peroxidation was measured by assaying levels of malonaldehyde, a by-product of the peroxidation reaction. young, adult and aged animals were fed a liquid antioxidant-free diet for 21 days prior to the hepatocyte isolation. cells isolated from young rats demonstrated the highest levels of lipid peroxidation (microgram o ... | 1982 | 7160445 |
| dimensionality of the body symptom questionnaire. | a good deal of recent research on somatic discomfort has employed the body symptom questionnaire of fisher and greenberg to quantify the perceived location of the somatic discomfort. certain formal psychometric properties of the instrument have not yet been established, and it is the purpose of this paper to do so. specifically, since the independence of the questionnaire scales has not been determined, it is a primary focus of this discussion. a principal axis method of factoring showed that th ... | 1982 | 7162908 |
| [ophthalmoplegia in fisher syndrome: a combination of peripheral, internuclear and supranuclear lesions]. | 1982 | 7167600 | |
| [fisher syndrome. report of 4 cases and review of the literature]. | 2006 | 7170463 | |
| axillary 5 alpha-androst-16-en-3-one, cholesterol and squalene in men; preliminary evidence for 5 alpha-androst-16-en-3-one being a product of bacterial action. | twenty-four hour axillary levels of the odorous steroid 5 alpha-androst-16-en-3-one, have been measured in six men by radioimmunoassay. initially, no control of bacterial activity was made and conditions attempting a normal axillary environment were maintained. the level of 5 alpha-androst-16-en-3-one was significantly higher (p = 0.028) in one axilla ("superior") than the other ("inferior") and levels showed considerable variation both between and within individuals. this difference between axi ... | 1982 | 7176644 |
| improving the visual discrimination of mentally retarded children: a training strategy. | mentally retarded children were asked to judge whether a series of visual stimuli matched a standard. with each judgment the investigator verbalized "right" or "wrong" and then provided full feedback of particulars, indicating with gesture and words the cue similarities and differences that supported each correct and each incorrect judgment. control subjects were either given no training (test--retest only) or were asked to make the judgments but given no feedback. attesting to the efficacy of t ... | 1982 | 7180891 |
| [isolation and significance of vibrio cholera nag]. | after the isolation of two vibrio cholerae nag from the stools of two tourists, the authors researched vibrio in people coming home from particular countries and in resident people. the research was extended to the water of varese lake after another isolation from a fisher who had fished, cooked and eaten the lake fish. problems concerning the classification of vibrio and their presence in the environment are examined. | 1982 | 7187344 |
| small deep infarcts diagnosed on computed tomography. | the clinical and angiographic correlations of small deep infarcts seen on computed tomography (ct) scan were studied in 297 consecutive patients. some of these showed the features described by fisher as part of the lacunar syndrome. in a large number, a source of emboli from either a cardiac or a carotid source was highly probable; in a smaller number, other vascular diseases were present. the finding of a small deep infarct on ct does not exclude the need for further investigation of a possible ... | 1980 | 7191500 |
| homolateral ataxia and crural paresis: case report. | homolateral ataxia and crural paresis is a recognized vascular syndrome. however, confirmation of the causative lesion rests principally on one earlier case with multiple other infarcts. we studied a patient with the clinical syndrome; computerized tomography revealed a lucency that appeared within 1 week of the infarct. localization of the lesion to the superior portion of the posterior limb of the internal capsule and thalamus is in accord with the original conclusions of fisher and cole. | 1980 | 7191530 |
| absorption of 14c-clanobutin-na isolated perfused intestinal segments in vitro of rats. | 1. the absorption of 14c-labelled 4-[4-chloro-n-(4-methoxyphenyl)-benzamido]-butyric acid (clanobutin) was investigated on isolated perfused jejunal segments of rats in vitro according to the method of fisher and parsons and using everted (wilson and wiseman) and non-everted sac preparations. 2. transfer to and content of the mucosal tissue of 14c-clanobutin in isolated perfused jejunal segments is proportional to the concentration administered on the mucosal side in the range of 1-100 mumol/l. ... | 1981 | 7194668 |
| fisher syndrome in childhood. | three children, age 2, 7, and 12, developed fisher syndrome: inability to walk because of ataxia, complete areflexia, and ophthalmoplegia. ptosis was prominent in all the children, but the pupillary response to light was affected only in one child. limb weakness was never present, and sensation normal. one patient was obtunded for several days. two had prodromal upper respiratory tract illnesses, and the third patient was bitten by an insect 2 days before her symptoms began. cerebrospinal fluid ... | 1981 | 7194971 |
| time factors and orgasmic response. | a retrospective review of data from a 619-member female sample presenting for treatment of sexual dysfunction was conducted to determine if foreplay and intromission duration variables were related to sexual dysfunction. patients were assigned to coitally anorgasmic and noncoitally anorgasmic, coitally anorgasmic and noncoitally orgasmic, or coitally and noncoitally orgasmic categories on the basis of interview data collected by a nurse-physician team. duration measure differences are not found ... | 1981 | 7195696 |
| presynaptic cholinergic mechanisms in brain of aged rats with memory impairments. | presynaptic cholinergic mechanisms were investigated in various brain regions of aged fisher 344 rats with documented 24 hr retention deficits measured in a single-trial passive avoidance tasks. sodium-dependent high affinity choline uptake was found to be decreased by 22% in hippocampus of 23-26 month old animals as compared to 6 month old controls. prior depolarization of hippocampal or cortical synaptosomes with k+ resulted in stimulation of choline uptake which was similar in aged rats and y ... | 1981 | 7197758 |
| dopamine receptor sensitivity following nigrostriatal lesion in the aged rat. | this investigation sought to determine whether the ability to regulate dopamine receptor sensitivity following removal of dopaminergic innervation is altered during aging. aged (24-26 months old) fisher 344 rats compared with young (6 months old) rats had lower levels of dopamine and dopamine receptor binding ([3h]adtn), but no change of dopamine-stimulated adenylate cyclase activity. unilateral lesion of the nigrostriatal pathway produced equivalent dopaminergic denervation in rats of both age ... | 1982 | 7199364 |
| fisher syndrome in childhood. | 1982 | 7201120 | |
| [comparison of the effect of premedication with diazepam and trazodone on anesthesia induced with althesin]. | interference on the part of premedication with diazepam and trazodone with althesin anaesthesia was investigated and compared by means of variance analysis according to fisher, and the x2c test according to yates, in 150 patients aged 35-45 yr in three groups of 50 during examination of the uterine cavity. no marked difference between the effects of the two drugs were noted, with two exceptions: 1) trazodone was better able to potentiate the hypnotic action of althesin, so that less was needed f ... | 1980 | 7219734 |
| [miller-fisher syndrome (author's transl)]. | 1980 | 7235516 | |
| age-strain interrelations in lipid metabolism of rats. | various aspects of lipid metabolism were compared in fisher 344 (f) and sprague-dawley (sd) rats aged 2, 6, 12, 18 and 24 months. the analyses included free and total cholesterol of serum and liver, lcat, hepatic hmg-coa reductase, cholesterol 7 alpha-hydroxylase, fatty acid synthetase, acetyl coa carboxylase and cholesterol synthesis from acetate or mevalonate. the body weight of sd rats increases with age whereas that of f rats plateaus at 9-12 months. liver and aorta cholesterol levels were c ... | 1981 | 7242272 |
| lung clearance of particles in two strains of rats. | two strains of commonly used experimental rats were compared with regard to lung clearance of tio2 particles. the fisher 344 inbred rats retained predictably fewer particles after a 7-hr exposure than the larger outbred long-evans rats. this fact can be expected in view of the different lung size of the two strains. in addition, clearance of the retained particles was significantly slower in fisher 344 rats. differences in lung clearance capacity of different animal strains should be considered ... | 1980 | 7250091 |
| acute and chronic effect of dietary cholic acid on colonic epithelial cell proliferation. | administration of cholic acid (1.0% of the diet) to male fisher rats for 3 days resulted in increased numbers of dna synthesizing epithelial cells per colonic crypt column as compared to those found in either control or 0.2% cholic acid-fed rats. the middle third of the crypt was the area stimulated to contribute the additional proliferating cells. the maximum number of 3h-tdr-labeled cells was doubled by 24 h and migration had processed further up the colonic crypt of the 1% cholic acid-fed rat ... | 1981 | 7250550 |
| evaluating comparative studies of paraprofessional and professional helpers: a reply to nietzel and fisher. | 1981 | 7255630 | |
| age changes on bone size and mass in two strains of senescent rats. | 6-month-old buffalo and fisher inbred rats were compared with their respective senescent counterparts. it appeared that length as well as weight of the various sections of the skeleton increased into old age. however, in some skeletal parts, length increase was greater than weight increase, so that relative robusticity of those parts, relating weight to length, dropped. the two different strains of rats showed differences in age-related bone reactions. thus, while in humans, age-related bone los ... | 1981 | 7257716 |
| the role of body mass in thermoregulation. | inbred fisher and buffalo rats were raised in small and in large litters and by such litter manipulation, large- and small-bodied animals were obtained within the same strain. when the rats were exposed to extreme cold and heat, it appeared that large-bodied rats in both strains survived longer in cold and small-bodied rats survived longer in heat. the two trends were clearly evident, and individual correlations between survival time and body mass were generally significant. however, there were ... | 1981 | 7258339 |
| induction of spinal cord paralysis by negative pi-mesons. | as part of our investigations on late non-neoplastic injury induced by negative pi-mesons (pions), a series of studies have been performed using pion beams for the induction of spinal cord paralysis in the fisher 344 rat. groups of rats were exposed to 1, 5 or 15 daily doses of peak pions or x rays. paralysis appeared earlier after treatment with pions than after x rays even in a comparison of groups with similar final incidences. a single dose rbe for spinal cord paralysis of 1.3 was found. the ... | 1981 | 7260512 |
| [syndrome of ophthalmoplegia, ataxia and areflexia of fisher in a 14 year old boy (author's transl)]. | the syndrome of ophthalmoplegia, ataxia and areflexia first mentioned in 1932 by collier and in 1938 by van bogaert was described more precisely in 1956 by fisher. it represents a specific clinical entity and is considered to be a variant of idiopathic polyradiculoneuropathy (guillain-barré). the most striking features are external (sometimes also internal) ophthalmoplegia, hyporeflexia or areflexia and cerebellar ataxia. during the first days paresthesias are frequently present whereas other di ... | 1981 | 7265807 |
| neuron numbers in locus coeruleus do not change with age in fisher 344 rat. | counts of neurons in locus coeruleus of fisher 344 rats of ages from 12 to 32 months showed no loss with advancing age. species comparisons of age changes in locus coeruleus neuron counts and measures of catecholamine systems suggested that the human and nonhuman primate locus coeruleus shows age changes and seen in rodent locus coeruleus. it is suggested that although rodent models of human aging have value under some circumstances, rodent and primate brain should not be considered equivalent w ... | 1981 | 7266740 |
| [prognostic clinical criteria in comatose conditions]. | a total of 98 comatose patients were reclassified according to the final stage of the disease by means of the discrimination procedure after fisher. those neurological symptoms and general clinical data were ascertained that were most important for the separation. the order of the characteristics according to their contribution to the separation shows a dependence upon the time of the examination. the different distinctiveness and degree of intensity of neurological symptoms are of different imp ... | 1980 | 7280132 |
| evaluation of megadose vitamin therapy in an experimental brain tumor. | a mixture of vitamins c and b12 in high dosage, which has been reported to eradicate ascites tumors in rats, was tested for its antineoplastic effect against the l9 glioma in fisher cdf strain rats. no difference in survival time between animals receiving the vitamin mixture and controls could be demonstrated. possible reasons for the different response to therapy in the two experimental tumor systems are discussed. | 1981 | 7280989 |
| phospholipid metabolism in livers of young and old fisher 344 and sprague-dawley rats. | 1981 | 7286096 | |
| formation of tissue-bound n'-nitrosonornicotine metabolites by the target tissues of sprague-dawley and fisher rats. | the distribution and metabolism of n' -[14c] nitrosonornicotine ([14c]nnu) was studied in sprague-dawley and fisher rats, in which nnn induces tumours preferentially of the nasal cavity and the oesophagus. after i.v. injections of [14c] nnn, a localization of tissue-bound metabolites weas found in the mucosa of the nasal cavity and oesophagus. these tissues were also found to have a capacity to form tissue-bound metabolites from nnn in vitro. these data suggest that in situ metabolic activation ... | 1981 | 7296763 |
| the molecular basis of dominance. | the best known genes of microbes, mice and men are those that specify enzymes. wild type, mutant and heterozygote for variants of such genes differ in the catalytic activity at the step in the enzyme network specified by the gene in question. the effect on the respective phenotypes of such changes in catalytic activity, however, is not defined by the enzymes change as estimated by in vitro determination of the activities obtained from the extracts of the three groups. in vivo enzymes do not act ... | 2013 | 7297851 |
| vocal tract control in parkinson's disease: phonetic feature analysis of misarticulations. | consonant articulation patterns of 200 parkinson patients were defined by two expert listeners from high fidelity tape recordings of the sentence version of the fisher-logemann test of articulation competence (1971). phonetic transcription and phonetic feature analysis were the methodologies used. of the 200 patients, 90 (45%) exhibited some misarticulations. phonetic data on these 90 dysarthric parkinson patients revealed articulatory errors highly consistent in detailed production characterist ... | 1981 | 7300262 |
| age related changes in the endocrine hypothalamus: i. tanycytes and the blood-brain-cerebrospinal fluid barrier. | the fine structural organization of the floor of the third cerebral ventricle (dorsum of the median eminence of the hypothalamus) of 2 normal adult mice fisher 344 rats was compared and contrasted with that of 2 aged rats 30 months old. closely juxtaposed tanycytes (specialized ependymal cells) of normal young adults in the lower walls and floor of the third ventricle. in contrast, tanycytes in aged rats demonstrated significant intracellular separations, with only fine cytoplasmic processes rem ... | 1981 | 7301040 |
| pituitary cell transplants to the cerebral ventricle suppress the pituitary of the recipient host. | implantation of 1 x 10(6) acutely dispersed rat pituitary cells into the lateral ventricles of sexually immature and mature female rats of both the sprague-dawley and fisher strains significantly suppressed the weight and protein content of the in situ pituitary 12 days postimplantation. body weight gains in the young animals were also significantly lower. changes in the in situ pituitary of the cell implanted groups were demonstrated by repeatable reductions (approximately 50%) in total pituita ... | 1981 | 7301052 |
| [evaluations of respiratory functional parameters in sponge fishers from the island of kalimnos (greece)]. | we had intended to study functional respiratory patterns of a sponge-divers group from the island of kalymnos (greece). such a group constitutes a very homogeneous sample for dietary habits and underwater activity, handed down from father to son. some of these sponge-divers dives holding his breath; others use "narghilè", a special apparatus consisting in a nosepiece connected to an air compressor placed in the boat. as their activity is continuative and prolonged for several months in the years ... | 1981 | 7306414 |
| immunoregulation by schistosoma mansoni. | schistosoma mansoni is known to release an inhibitory factor of lymphocyte proliferation elicited in vitro. the effect of this dialyzable schistosome incubation product (dsip) was tested in vivo on different aspects of the cell-mediated immune response. first, the dsip injected into c57b1/6 mice markedly inhibited the delayed type hypersensitivity to sheep red blood cells (srbc). furthermore, the dsip injected into s. mansoni infected fisher rats at the beginning of the infection induced an inhi ... | 1981 | 7309493 |
| adrenaline neurons and pnmt activity in the brain and spinal cord of genetically hypertensive rats and rats with doca--salt hypertension. | 1. we have studied the number of phenylethanolamine-n-methyltransferase (pnmt)-containing nerve cells in the medulla and the activity of pnmt in the medulla, spinal cord and hypothalamus of the rat. 2. at 4 weeks of age there was an increase in the number of pnmt cells counted in the medulla of the spontaneously hypertensive rat (shr; 21%, p less than 0.01) and the stroke-prone spontaneously hypertensive rat (shr-sp; 22%, p less than 0.01) compared with the wistar--kyoto (wky) control rat. 3. at ... | 1981 | 7318327 |
| [fisher syndrome : immunologic disease?]. | 1981 | 7322909 | |
| potassium loss associated with hydrochlorothiazide versus chlorthalidone. | a retrospective survey using chart review was conducted to determine the incidence of clinically significant hypokalemia resulting from therapy with chlorthalidone (ctld) or hydrochlorothiazide (hctz). the frequency of hypokalemia, potassium less than or equal to 3.0 meq/liter, was 4/29 patients (13.8%) in the ctld once-daily group, 0/17 in the hcdl twice-daily group, and 0/31 in the hctz once-daily group. using the fisher exact probability test, a significant difference in the incidence of hypo ... | 1981 | 7332917 |
| fisher syndrome. report of a case. | 1981 | 7337002 | |
| exact significance levels for multiple binomial testing with application to carcinogenicity screens. | a simple experimental design consisting of one control group and one or more treatment groups is considered. relevant research often focuses on the presence or absence of any of several characteristics in the treatment group(s). the statistical analysis frequently includes the comparison of the control group with each treatment group by the use of fisher-irwin exact tests for each of many 2 x 2 tables. the multiplicity of comparisons has given rise to concern that individual fisher-irwin tests c ... | 1981 | 7337794 |
| further discussion of the hip and the stanford form c: a reply to a reply by frischholz, spiegel, tryon, and fisher. | 1981 | 7340496 | |
| symposium on cerebrovascular disease in honor of c. miller fisher. | 1980 | 7348969 | |
| effects of lactose and mode of sterilization of a lactose diet on mineral metabolism in germ-free and conventional rats. | mineral balances of ca, p, mg, k, na, zn, mn, cu were carried out on 6-week old fisher rats for 14 consecutive days. four lots of germfree (gf) and 4 lots of conventional (cv) rats were fed a semi-synthetic diet at weaning containing either 0 or 10 p. 100 of lactose (l). the diet was sterilized either by irradiation (i) or by autoclave (au). lactose, when added to the diet, caused very variable modifications of the mineral metabolism, depending on the mineral studied and the mode of sterilizatio ... | 1980 | 7349413 |
| earmuffs, exploratory head movements, and horizontal and vertical sound localization. | in a semi-anechoic room, normal-hearing adults judged the position of that loudspeaker emitting a narrow-band noise centered at 1 kc/s, from a vertical array of 10 loudspeakers in 18 degrees steps, or a similar horizontal-arc array intersecting at 0 degrees azimuth and 0 degrees vertical. stimuli were narrow-band noise bursts terminated by s when judgment was made. ss (n:17) were free to move their heads, or were asked to restrict such movement. in the horizontal plane, ss without earmuffs and w ... | 1981 | 7349864 |
| [action of n-nitrosomethylurea on antitumor antibiotic-resistent substrains of fisher l-5178 lymphadenosis]. | 2013 | 7358895 | |
| charge forms of wistar rat alpha-lactalbumin. a contradiction. | alpha-lactalbumin was purified from the milk of wistar rats and was compared to that obtained from fisher 344 rats. alpha-lactalbumin isolated from the wistar rat exists as two forms which differ in their sialic acid content, as the desialyated forms migrate to one identical position on polyacrylamide gels. these two charge forms are identical with the charge forms ii and iii previously characterized from fisher rat alpha-lactalbumin. no evidence was found to verify previous reports that one for ... | 1980 | 7380837 |
| the not-so-benign miller fisher syndrome: a variant of the guilain-barré syndrome. | two patients with fisher's syndrome of ophthalmoplegia, ataxia, and areflexia experienced severe weakness and respiratory distress. both patients required tracheostomy and assisted ventilation, but both made a complete recovery. fisher's syndrome is generally considered to be a benign variant of acute infectious polyneuropathy (the guillain-barre syndrome). our two patients demonstrate that the condition is not always benign. | 1980 | 7387472 |
| lines of descent in the diffusion approximation of neutral wright-fisher models. | 1980 | 7404432 | |
| allele frequencies in multidimensional wright-fisher models with a general symmetric mutation structure. | 1980 | 7404433 | |
| body build and temperature tolerance: an experimental analysis of ecological 'rules'. | according to current anthropological theory, the two factors that primarily determine thermoregulation in human populations are body size and body proportions, and they have found their formulation in the ecological 'rules' of bergmann and allen. in order to test the validity of these idea, buffalo and fisher rats were submitted to various levels of heat and cold. the two strains were chosen because they demonstrate maximum differences in body size and body proportions in domesticated rats. the ... | 1980 | 7405512 |
| [fisher syndrome]. | in 1956, fisher described a variant of guillain-barré syndrome characterized by ophthalmoplegia, ataxia and areflexia. there is spontaneous remission within several weeks or months. etiology and pathogenesis are not yet clear. a lesion in the brain stem or of peripheral neurons, or a combination of central and peripheral lesions are considered possible causes. a case history is presented as an example of this rare syndrome. | 1980 | 7421061 |
| dog bite wounds and infection: a prospective clinical study. | we prospectively studied 26 patients with 27 dog bite wounds who sought medical attention in the emergency department. two distinct populations were found (fishers exact test, p less than or equal to 0.001): 1) those who presented 8 hr to 12 hr post-injury were concerned about rabies or tetanus or surgical wound repair; and 2) those who presented more than 12 hr post-injury were concerned with infection. there was no difference (p > 0.05) in the bacteriology of the two groups. of all wounds, 74% ... | 1980 | 7425403 |
| cholesterol synthesis in tissues of young and old fisher 344 and sprague-dawley rats. | 1980 | 7428858 | |
| energy-linked mitochondrial transhydrogenation from nadph to nadp analogs. | the mitochondrial energy-linked transhydrogenase enzyme catalyzes hydride ion transfer between nad and hadp, of which the reaction nadh leads to nadp is slow in the absence of energy and is accelerated 10-fold or more when the mitochondrial membrane is energized by atp hydrolysis or respiration. the enzyme is a proton pump and effects proton translocation coupled to hydride ion transfer from nadph to nad (earle, s.r., and fisher, r.r. (1980) j. biol chem. 255, 827-830). the present studies have ... | 1980 | 7430092 |
| relationship between increased aerobic glycolysis and dna synthesis initiation studied using glycolytic mutant fibroblasts. | reports from several laboratories have suggested increased rates of glycolysis play an essential part in the initiation of dna synthesis. this is based on observations that aerobic glycolysis: (1) occurs at low rate in resting mammalian cells and at very high rate in tumour cells; (2) increases rapidly after dna synthesis is initiated by addition of serum or purified growth factors, and (3) correlates with the expression of the transformed phenotype. also, specific inhibitors of aerobic glycolys ... | 1980 | 7432468 |
| effect of n-nitrosomethylurea on substrains of fisher lymphadenosis l-5178 resistant to antitumoral antibiotics. | a cytogenetic analysis of variants of fisher mouse lymphadenosis l-5178 resistant to the antitumoral antibiotics bruneomycin and rubomycin c showed that the cytogenetic characteristics of the changes in the tumor cell population correlate with the chemotherapeutic indices of the development of drug resistance. cytogenetic and kinetic analyses showed that variants of fisher lymphadenosis l-5178 resistant to bruneomycin and rubomycin c retain sensitivity to n-nitrosomethylurea (nmu). the activity ... | 1980 | 7437480 |
| in vitro release of biologically active adriamycin by magnetically responsive albumin microspheres. | the kinetic release of therapeutically active adriamycin from two different heat-stabilized preparations of magnetically responsive albumin microspheres (1 micron) has been evaluated using a rapid in vitro bioassay-harvesting system. release products are added to freshly plated monolayers of a malignant fisher 344 rat fibrosarcoma cell line, and the inhibition of [3h]uridine incorporation into trichloroacetic acid-precipitable material (rna) and whole cells is determined in a 6-hr microtiter ass ... | 1980 | 7438037 |
| consideration of the possible carcinogenicity of some pesticides. | the sophistication, sensitivity, and the predictability of carcinogenesis bioassays using small rodents is reviewed. bioassays were conducted using both sexes of mice (b6c3f1:c57bl/6xc3h f1 hybrid) and rats (osborne-mendel or fisher 344). chemicals tested included three acaracides, two fungicides, two fumigants, four herbicides, twelve chlorinated insecticides, and five organo-phosphorus insecticides. the tumor response of each test strain and sex to the above chemicals is discussed, as well as ... | 1980 | 7440922 |
| iodothyronine kinetic studies in the newborn lamb. | metabolic clearance rates and production rates for thyroxine (t4), triiodothyronine (t3) and reverse t3 (rt3) were determined by pulse injection kinetic techniques in newborn sheep between 7 and 14 days of age. the mean metabolic clearance rate for t3 (39.6 +/- 4.5 l/m2 per day) was significantly greater than that for t4 (7.25 l/m2 per day, p < 0.001). the mean value for rt3 (27.5 +/- 2.8 l/m2 per day) also exceeded that for t4 (p < 0.001) but did not differ from that for t3. the mean production ... | 1980 | 7440940 |
| [effect of concanavalin a on the splenic lymphocyte proliferative activity of germ-free rats]. | action of con-a on the proliferative activity of spleen lymphocytes was studied using germfree and conventional fisher rats 3-4 months of age and conventional 2-3 day old rats. the intensity of 3h-thymidine incorporation in lymphocytes of germfree and conventional animals was the same, however, the coefficient of stimulation was higher in germfree rats. lymphocytes of suckling rats had a low reactivity to con-a. | 1980 | 7445093 |
| the c1q binding assay in systemic lupus erythematosus: discordance with disease activity. | to investigate the relationship of c1q binding assay (c1qba) to disease activity in systemic lupus erythematosus (sle), a retrospective study was carried out on 232 c1qba performed in 33 patients with sle. when initial values were assessed (33 tests in 33 patients), there was no relationship between positive and negative c1qba and abnormal renal function (p = 0.482, fisher exact test). of 87 tests performed during active renal disease, 34 (39%) were positive; of 48 tests during active non-renal ... | 1980 | 7447962 |
| [althesin in cesarean section]. | the effects of althesin (group a) and thiopentone (group b) in mother and newborn were compared after their use in the induction of narcosis in 80 patients undergoing caesarean section. the mean doses of althesin (0.072 ml/kg i.v.) and thiopentone (4.1 mg/kg i.v.) proved sufficient to guarantee rapid onset of sleep (about 20 seconds) in both groups. as of cardiovascular effects on the mother in the induction-extraction period, greater stability of cardiac frequency (c.f.) was noted with thiopent ... | 1980 | 7454004 |
| the antitumour activity of maltose tetrapalmitate compared with other immunoadjuvants, and its effectiveness after tumour surgery. | the effectivenss of maltose tetrapalmitate (mtp) as an antitumour immune adjuvant was verified by its comparison with other known immunopotentiators, namely bcg, corynebacterium parvum, levamisole and pyran copolymer. copenhagen x fisher 344/crbl f1 hybrid male rats inoculated s.c. with the dunning r3327a prostatic adenocarcinoma were used as the test system. all animals treated with immunoadjuvants showed a delay in tumour appearance and inhibition of early tumour growth. mtp was found to be th ... | 1980 | 7459208 |
| effect of cigarette smoking on susceptibility to lung cancer. | fisher first suggested that genetic predisposition to lung cancer is a more important factor than cigarette smoking, and that therefore one may smoke. recently, this thesis has been defended strongly by burch. here, a literature survey has been done that indicates that the genetic susceptibility for development of lung cancer varies between individuals. but it is wrong to conclude from this that therefore one may smoke. such a conclusion only would be valid, if there was a close relationship bet ... | 1981 | 7465162 |
| successful methotrexate therapy in oral florid papillomatosis. | oral florid papillomatosis is a rare syndrome, which was first described under this name by rock & fisher in 1960. the same syndrome had been previously described as papillomatosis mucosae oris carcinoides by scheicher-gottron (1958). it is a benign condition, capable of malignant degeneration. surgical excision and electrocoagulation are the most widely used therapeutic methods, despite the fact that relapse of symptoms after treatment by these methods is common. the literature comprises a few ... | 1980 | 7471503 |
| campylobacter jejuni infection and guillain-barré syndrome. | although infection with campylobacter jejuni is recognized as a common antecedent of the guillain-barré syndrome, the clinical and epidemiologic features of this association are not well understood. | 1995 | 7477117 |
| first person account: schizophrenia--adrift in an anchorless reality. | the article that follows is part of the schizophrenia bulletin's ongoing first person accounts series. we hope that mental health professionals--the bulletin's primary audience--will take this opportunity to learn about the issues and difficulties confronted by consumers of mental health care. in addition, we hope that these accounts will give patients and families a better sense of not being alone in confronting the problems that can be anticipated by persons with serious emotional difficulties ... | 1995 | 7481579 |
| statistical properties of segregating sites. | a mutation leading to a segregating site of a sample can be classified by the number of sequences in the sample that inherits the mutant nucleotide; it can also be classified by the frequencies of the two segregating nucleotides at the resulting segregating side. we define the size of a mutation to be the number of sequences in the sample that inherits the mutant nucleotide and the type of mutation (segregating site) to be the smallest value of the frequencies of segregating nucleotides. each of ... | 1995 | 7482370 |
| pharmacologically induced regression of chronic transplant rejection. | chronic rejection, characterized by a progressive obliterative arteriopathy, is a major cause of graft failure in long-surviving human transplants for which there is no effective treatment. leflunomide, an isoxazol derivative, has been shown to be a novel immunomodulatory drug that profoundly suppresses the immune response. in this study, 58 fisher-344 rats received cardiac transplantation from lewis rats. all the recipients were given csa at 2.5 mg/kg for 5 days postoperatively. without further ... | 1995 | 7482709 |
| modulation of amblyopia therapy following early surgery for unilateral congenital cataracts. | stimulus deprivation amblyopia is the principal cause of visual impairment in infants with unilateral congenital cataract. even if lensectomy is undertaken at an early age, intensive postoperative occlusion of the phakic eye is essential for the development of useful vision in the aphakic eye. despite this, the optimum method of regulating occlusion therapy is uncertain. | 1995 | 7488596 |
| monocyte chemoattractant protein-1 (mcp-1) gene transduction: an effective tumor vaccine strategy for non-intracranial tumors. | recently, there has been renewed interest in the concept of tumor vaccines using genetically engineered tumor cells expressing a variety of cytokines to increase their immunogenicity. human mcp-1 (je) is a potent chemoattractant and activator of monocytes and t lymphocytes and thus a good candidate gene for a tumor vaccine. we therefore evaluated the efficacy of vaccines consisting of irradiated tumor cells transduced with the murine mcp-1 gene in the syngeneic 9l gliosarcoma brain tumor model. ... | 1995 | 7489565 |
| role of gastric blood flow in impaired defense and repair of aged rat stomachs. | to study impaired gastric mucosal tolerance against noxious agents in aged rats, possible factors underlying this observation were compared in anesthetized fisher 344 young and aged rats. the gastric mucosa was damaged by in situ exposure to 80% ethanol for 30-45 s and by 1 m nacl for 10 min followed by saline (ph = 1.0) for 60 min in chambered stomachs. the lesion area was significantly larger and epithelial restitution was significantly slower in aged than in young rats after both types of inj ... | 1995 | 7491966 |
| restoration of tumor oxygenation after cytotoxic therapy by a perflubron emulsion/carbogen breathing. | female, fisher 344 rats bearing 13762 mammary carcinoma implanted subcutaneously in a hind limb were treated with standard therapeutic single doses of antitumor treatments of several types including: 1) antitumor alkylating agents (cisplatin, cyclophosphamide); 2) natural products (adriamycin, taxol and etoposide); 3) antimetabolites (5-flourouracil); 4) hypoxic cell selective agents (mitomycin c, sr-4233) as well as 5) fractionated radiation therapy (3 gray daily for 5 days). the oxygen levels ... | 1995 | 7493063 |
| increased tumor oxygenation and radiation sensitivity in two rat tumors by a hemoglobin-based, oxygen-carrying preparation. | the rat 13762 mammary carcinoma and the rat 9l gliosarcoma were grown subcutaneously in a hind limb of female, fisher 344 rats. the oxygen content of the tumors was determined using an eppendorf po2 histograph. fifty-to-sixty oxygen measurements were made per tumor and there were 8-to-10 animals per group. the percent of po2 readings < or = 5 mmhg in the mammary carcinoma was 49%, this was decreased to 34% by administration of the hemoglobin preparation (8 ml/kg) and further decreased to 29% whe ... | 1995 | 7493064 |
| the penumbra, therapeutic time window and acute ischaemic stroke. | there is a great deal of evidence that an ischaemic penumbra exists in animals and humans after the occurrence of focal brain ischaemia (hossmann, 1994). the concept of the penumbra leads to the idea of a therapeutic time window. because, if the region of irreversible injury (infarction) after focal ischaemia evolves in time and space, then the possibility of therapy to interfere becomes a tenable hypothesis. all of the acute stroke therapies given after onset have their basis from this hypothes ... | 1995 | 7496621 |
| wortmannin, an inhibitor of phosphoinositide 3-kinase, inhibits transcytosis in polarized epithelial cells. | wortmannin, an inhibitor of phosphoinositide 3-kinase, inhibits both basolateral to apical and apical to basolateral transcytosis of ricin in fisher rat thyroid (frt) cells by 50% at 100 nm in a continuous transcytosis assay. in mdck cells, a similar effect of wortmannin on basolateral to apical transcytosis of ricin was found, whereas apical to basolateral transcytosis was inhibited to a lesser degree. transcytosis of dimeric iga in mdck cells expressing the polymeric immunoglobulin receptor wa ... | 1995 | 7499348 |
| hla-class ii alleles in guillain-barré syndrome and miller fisher syndrome and their association with preceding campylobacter jejuni infection. | hla typing for class ii alleles was performed on 97 patients with guillain-barré syndrome or miller fisher syndrome and compared with 100 controls. there was a significant association between hla-dqb1*03 and preceding campylobacter jejuni infection (pc = 0.05). | 1995 | 7499492 |
| prognostic value of the amount of post-traumatic subarachnoid haemorrhage in a six month follow up period. | clinical and radiological patterns from 148 patients with post-traumatic subarachnoid haemorrhage (tsah) were analysed with specific regard for the amount and distribution of blood in subarachnoid spaces to verify if these variables have any influence on overall outcome. the degree and extent of tsah were classified according to fisher's criteria: in 93 patients it was grade 1, in 36 grade 2, in 13 grade 3, and in six grade 4. there was a significant correlation between increasing clinical sever ... | 1995 | 7500106 |
| psychiatric disease and cytomegalovirus viremia in renal transplant recipients. | although cytomegalovirus (cmv) is rarely cultured from peripheral-blood leukocytes of immunocompetent patients, it may be cultured from up to 60% of renal transplant recipients, 1 to 4 months after transplantation. during this same period, renal transplant recipients are often referred for psychiatric evaluation. since cmv may infect the central nervous system, the relationship between isolation of cmv from peripheral-blood leukocytes (viremia) and psychiatric evaluation was investigated in 80 r ... | 1995 | 7501787 |
| age-related shortening of poly(a) tail of albumin mrna. | to determine the molecular mechanisms of age-related changes in hepatic albumin gene expression, male fisher 344 rats at 4, 12, and 24 months of age were studied. the hepatic albumin content was modestly increased by 20% and plasma albumin concentration was not altered with age. there were no age-related changes in albumin mrna content of the liver. the in vivo synthetic rate of albumin as measured with [14c]-leucin incorporation in 4-month-old rats (350 +/- 24.5 cpm) was not significantly diffe ... | 1995 | 7503543 |
| unexplained elevations of maternal serum alpha-fetoprotein in women with antiphospholipid antibodies: a harbinger of fetal death. | to determine whether unexplained elevations of maternal serum alpha-fetoprotein (msafp) in women with antiphospholipid antibodies are associated with adverse pregnancy outcomes. | 1994 | 7505912 |
| aging impairs galanin expression in luteinizing hormone-releasing hormone neurons: effect of ovariectomy and/or estradiol treatment. | in the medial preoptic area and the diagonal band of broca, a subset of lhrh neurons coexpresses galanin at a 4- to 5-fold higher rate in female than male rats, suggesting that estradiol (e2) plays a key role in galanin gene expression within lhrh neurons. in the present studies we investigated the incidence of colocalization of these peptides in different age groups, i.e. 2-, 10-, 18-, and 24-month-old intact female fisher rats; 24-month-old e2-treated rats; 24-month-old ovariectomized (ovx) ra ... | 1994 | 7506207 |
| in vivo characterization of the tachykinin receptors involved in the direct and indirect bronchoconstrictor effect of tachykinins in two inbred rat strains. | three receptors for the tachykinins, nk1, nk2, and nk3, have been defined pharmacologically and have been cloned. we previously demonstrated that in fisher 344 (f344) rats neurokinin a (nka) and substance p (sp) cause bronchoconstriction mainly by indirect mechanisms that involve both cholinergic nerves and mast cells. preliminary results suggested that in a less responsive strain, the bde strain, tachykinins did not activate airway mast cells. we have now compared in f344 and bde rats the airwa ... | 1994 | 7513594 |
| acquisition of pseudomonas cepacia at summer camps for patients with cystic fibrosis. summer camp study group. | to assess the risk of acquisition of pseudomonas cepacia by person-to-person transmission at cystic fibrosis summer camps, we conducted in 1990 a study at three camps attended by patients with cystic fibrosis who had p. cepacia infection and patients without p. cepacia infection but who were considered susceptible to infection. we obtained sputum or throat cultures from campers on their arrival at, weekly during, at the end of, and 14 to 30 days after camp. we compared the incidence of sputum co ... | 1994 | 7513755 |
| localization, synthesis, and processing of surfactant protein sp-c in rat lung analyzed by epitope-specific antipeptide antibodies. | surfactant protein c (sp-c), a 3.7-kda hydrophobic lung-specific protein, is synthesized and secreted by pulmonary type ii cells through proteolytic processing of a 21-kda propeptide (sp-c21) by currently undefined pathways. previously, we reported the production of a polyclonal antibody against rat sp-c21 (anti-cprosp-c) using a synthetic peptide as the immunizing antigen (beers, m. f., wali, a., eckenhoff, m. e. f., feinstein, s., fisher, j. h., and fisher, a. b. (1992) am. j. respir. cell. mo ... | 1994 | 7519606 |
| lung monocyte chemoattractant protein-1 gene expression in bleomycin-induced pulmonary fibrosis. | recent studies indicate that monocyte chemoattractant protein-1 (mcp-1) may play an important role in pulmonary inflammation. in vitro studies show that a number of cell types are capable of producing mcp-1. in this study, mcp-1 expression in lungs of rats with bleomycin (blm)-induced pulmonary fibrosis is examined to evaluate its cellular origin and potential role in pathogenesis. lung fibrosis was induced in male fisher 344 rats by endotracheal injection on day 0. on selected days after inject ... | 1994 | 7525714 |
| radiation-induced changes in the profile of spinal cord serotonin, prostaglandin synthesis, and vascular permeability. | to investigate the profile of biochemical and physiological changes induced in the rat spinal cord by radiation, over a period of 8 months. | 1995 | 7527800 |
| loss of heterozygosity in 8p is associated with microinvasion in colorectal carcinoma. | loss of heterozygosity (loh) from the short arm of chromosome 8 is frequent in a variety of malignancies, suggesting the presence of a tumor suppressor gene in this region. previous studies suggested that this deletion may correlate with higher clinicopathologic stages in colorectal cancer, but others did not support this finding; in part, this difficulty is due to the low heterozygosity of the rflp markers that were used. here we report on a preliminary investigation in which we used highly inf ... | 1994 | 7530488 |
| hydroxyl radical generation and nitric oxide synthase activity in fisher 344 x brown-norway f1 rat brain. | hydroxyl radical production in the cerebral cortex, striatum and hippocampus of young (6 months), middle-aged (15 months) and old (28 months) fisher 344 x brown-norway f1 rats was quantitated by measuring the salicylate hydroxyl radical-trapping product, 2,5-dihydroxybenzoic acid. the levels of hydroxyl radical between different age groups in each region examined were not statistically different. in all regions, with the exception of hippocampus from old rats which had a lower content of hydroxy ... | 1994 | 7531314 |
| serum anti-gq1b igg antibodies recognize surface epitopes on campylobacter jejuni from patients with miller fisher syndrome. | three patients who had diarrhea prior to the development of miller fisher syndrome are presented. campylobacter jejuni was isolated from stool specimens from all patients. high titers of anti-gq1b igg antibodies were demonstrated in the serum of these patients by enzyme-linked immunosorbent assay and thin-layer chromatography overlay. in enzyme-linked immunosorbent assay inhibition studies the anti-gq1b igg antibodies bound specifically to whole bacteria of the miller fisher syndrome-associated ... | 1995 | 7531419 |