Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| age and seasonal changes in the testis of the ferret. | 1968 | 5691854 | |
| reciprocal insemination and egg transfer between ferrets and mink. | 1968 | 5700166 | |
| ultrastructure of the pars intermedia of the ferret. | 1968 | 5712081 | |
| comparison of overt and inapparent influenzal infection in ferret. | 1968 | 5715898 | |
| antival activity of cyclooctylamine hydrochloride in influenza virus-infected ferrets. | 1968 | 5735361 | |
| prevention by pinealectomy of light-accelerated oestrus in the ferret. | 1968 | 5751895 | |
| clinical observation of experimental pseudorabies in mink and ferrets. | 1968 | 5752023 | |
| degeneration and regeneration of hypothalamic nerve fibers in the neurohypophysis after pituitary stalk section in the ferret. | 1969 | 5780526 | |
| pathogenesis of and recovery from respiratory syncytial and influenza infections in ferrets. | 1969 | 5782934 | |
| contraceptive action of intra-uterine devices in the ferret. | 1969 | 5788215 | |
| observations on the morphology of a nucleus in the dorsolateral funiculus of the spinal cord of the guinea-pig, rabbit, ferret and cat. | 1969 | 5788726 | |
| reproduction in the ferret (mustela furo). ii. changes following ovariectomy during early pregnancy. | 1969 | 5789961 | |
| the yellow colour of the lens of the grey squirrel (sciurus carolinensis leucotis). | 1. the absorption spectrum of the lens of the grey squirrel (sciurus carolinensis leucotis) has been measured, revealing an absorption maximum at 370 nm. peak densities in the intact lens ranged from 12 to 20.2. this peak is not present in the lenses of horse, cow, pig, dog, cat, ferret (mustelo furo), or guinea-pig (cavia porcellus).3. the pigment responsible for this absorption is water-soluble and aqueous extracts have been examined. protein-free aqueous extracts show an additional maximum at ... | 1969 | 5796470 |
| the pineal gland and light-induced oestrus in ferrets. | 1969 | 5813898 | |
| plasma progesterone levels in pregnant, pseudopregnant and anestrous ferrets. | 1969 | 5816162 | |
| comparison between the immunizing effect in dogs and ferrets of living distemper vaccines, attenuated in dog tissue cultures and embryonated eggs. | 1965 | 5864792 | |
| [pathological studies on canine distemper. 1. histopathological changes in ferrets infected with experimental canine distemper]. | 1965 | 5896588 | |
| original antigenic sin in ferrets: the response to sequential infections with influenza viruses. | 1966 | 5921310 | |
| pathogenesis of influenza in ferrets: nasal manifestations of disease. | 1966 | 5924078 | |
| pathogenesis of influenza in ferrets. i. tissue and blood manifestations of disease. | 1966 | 5936291 | |
| delta-5-3-beta-hydroxysteroid dehydrogenase activity in the steroid-hormone producing organs of the ferret (mustela putorius furo). | 1966 | 5943004 | |
| reciprocal transplantation of eggs between rabbit and ferret. | 1966 | 5960621 | |
| the somatic chromosomes of the ferret. | 1966 | 5961991 | |
| comments on ferret-origin distemper vaccines. | 1966 | 6008151 | |
| learning-set formation by mink, ferrets, skunks, and cats. | the ability of mink, fer rets, skunks, and cats to learn to dis criminate between objects was com pared. performance of mink and fer rets was similar to that reported for primates. this observation suggests that there is considerable overlap among mammals in ability to form learning sets. | 1967 | 6020488 |
| effects of castration and of progesterone implantation on muscle composition in the ferret. | 1967 | 6027810 | |
| effects of intertrial confinement and brightness change on ferret alternation behavior. | 1967 | 6043043 | |
| lymphatic leukaemia associated with dysproteinaemia in ferrets. | 1967 | 6055398 | |
| effects of medroxyprogesterone acetate and of ethinyl oestradiol on the fertilization and transportation of ferret eggs. | 1967 | 6066773 | |
| experimental observations on the ferret corpus luteum of pregnancy. | 1967 | 6066776 | |
| the feedback action of ovarian hormones in the ferret. | 1967 | 6067387 | |
| light and the control of the oestrous cycle in the ferret. | 1967 | 6069267 | |
| the histochemical localization of cytochrome oxidase in the retina and lateral geniculate nucleus of the ferret, cat, and monkey, with particular reference to retinal mosaics and on/off-center visual channels. | the histochemical localization of cytochrome oxidase within the normal retina and lateral geniculate nucleus (lgn) of cats, ferrets, and monkeys revealed that distinct layers, types of cells, and portions of neurons are more intensely stained than others. the dark staining of photoreceptor inner segments and cone pedicles and the light staining of photoreceptor outer segments, somata, and rod spherules demonstrates that different segments of the same cell may have disparate but distinct levels o ... | 1984 | 6092560 |
| aleutian disease virus in b and t lymphocytes from blood and spleen and in bone marrow cells from naturally infected mink. | in the nuclei of 4% of peripheral blood or spleen mononuclear cells (mnc), aleutian disease virus(adv)-specific antigens were found by a direct immunofluorescence test. the mnc were further fractionated by nylon wool, affinity chromatography using staphylococcus aureus protein, or percoll gradient techniques. adv and specific antigens were detected in mnc fractions enriched in either the b or t lymphocytes. in the bone marrow, up to 40% antigen-positive cells were demonstrated over a period of 1 ... | 1984 | 6096293 |
| pancreatic beta cell tumor in a ferret. | a ferret with clinical and laboratory signs of hypoglycemia was found at surgery to have a beta cell tumor of the pancreas. there had been recurrent episodes of weakness, ataxia, dehydration, and hypothermia. a fasting blood glucose content was 43 mg/dl and the amended insulin/glucose ratio was 362.5. the tumor was removed, yet hypoglycemia persisted postoperatively. clinical signs related to hypoglycemia did not recur following application of medical treatment and frequent feedings. the histolo ... | 1984 | 6096338 |
| alteration of cytoplasmic ionized calcium levels in smooth muscle by vasodilators in the ferret. | aequorin was used as an indicator of cytoplasmic ca2+ levels during the action of vasodilators in potassium-depolarized strips of ferret portal vein. moderate concentrations of isoprenaline produced either no change or an increase in cytoplasmic ca2+ levels during smooth muscle relaxation. only in the presence of very high concentrations of isoprenaline (greater than 10(-4) m) was a decrease in intracellular ca2+ levels detectable. both papaverine and forskolin also caused relaxations of the mus ... | 1984 | 6096534 |
| instinctive predatory behavior of mustelids (mustela putorius f. furo, mustela vison f. dom.) modified by benzodiazepine derivatives. | the predatory behavior of the ferret and of the mink consists mainly of instinctive behavioral patterns that are elicited by simple external stimuli. an important stimulus is size of the prey; the time needed to catch and kill defensive prey depends on the size of the prey in relation to that of the predator. benzodiazepine derivatives like chlordiazepoxide or lorazepam affect the prey catching of both species significantly. drugged animals (2 mg/kg orally) need less time to overpower their prey ... | 1981 | 6113610 |
| species differences in the metabolism of 3-phenoxybenzoic acid. | the metabolism of 3-phenoxybenzoic acid (3pba) (10 mg/kg, ip) has been studied in ten mammalian and one avian species in comparison with that of benzoic acid. 3pba exhibits wide species diversity in its metabolism, unlike benzoic acid, of which benzoylglycine (hippuric acid) is the major urinary metabolite in all species studied. with 3pba, glycine conjugation is the major route of metabolism in three species (sheep, cat, and gerbil), whereas in the mouse the taurine conjugate is the principal m ... | 1981 | 6114835 |
| bifluranol, a novel fluorinated bibenzyl anti-androgen, its chemistry and disposition in different animal species. | the synthesis of bifluranol, a new fluorinated bibenzyl anti-androgen, and of 3h-labelled bifluranol is described. the absorption, distribution and excretion of bifluranol has been studied in mouse, rat, ferret and dog; it is readily absorbed following oral administration, but blood concentrations of the drug are low due to hepatic uptake and biliary excretion. enterohepatic re-circulation occurs, but the drug is excreted primarily in the faeces and only small amounts appear in urine. this patte ... | 1981 | 6116777 |
| the metabolism of bifluranol by rat, dog and ferret. | the synthesis of monohydroxy- and dihydroxy-bifluranol, and of glucuronide and sulphate conjugates of bifluranol are described. bifluranol administered orally to rats, ferrets and dogs at a dosage of 50 to 200 microgram kg-1 is mostly excreted in the faeces as unchanged bifluranol and bifluranol monosulphate, disulphate and monoglucuronide. the bifluranol is well absorbed and is mostly excreted in the bile, as six different conjugates, including a glucuronide sulphate found in all 3 species, and ... | 1981 | 6116778 |
| species variations in the renal and hepatic conjugation of 3-phenoxybenzoic acid with glycine. | 1. 3-phenoxy[14c]benzoyl-coa has been chemically synthesized, purified and characterized by field-desorption mass spectrometry. biological activity of the purified thioester was greater than 92%. 2. the two enzymic steps involved in the conjugation of 3-phenoxybenzoic acid (3pba) with glycine have been investigated in hepatic and renal tissues from various mammalian species. 3. a 10- to 300-fold excess of acyl-coa: glycine n-acyltransferase activity as compared with acyl-coa synthetase activity ... | 1981 | 6118977 |
| neurotransmitter chemistry of lissencephalic cortex induced in ferrets by fetal treatment with methylazoxymethanol acetate. | treatment of pregnant ferrets with 15 mg/kg of methylazoxymethanol acetate (mam) at 33 days of fetal gestation results in offspring with cortical hypoplasia and lissencephally. neurochemical analysis of 5 areas of cortex from 8-week-old offspring of mam- or vehicle-treated jills indicated an overall enrichment in markers for catecholaminergic (tyrosine hydroxylase, norepinephrine) and cholinergic (choline acetyltransferase, acetylcholine) terminals but minimal change in the concentration of gaba ... | 1982 | 6125249 |
| localization and release of lysozyme from ferret trachea: effects of adrenergic and cholinergic drugs. | lysozyme is a bacteriolytic enzyme found in respiratory tract fluid. in this study, immunocytochemistry was used to determine the cells of origin of tracheal lysozyme in the ferret. lysozyme was found in secretory granules of serous but not mucous cells in the submucosal glands, and was absent from the surface epithelium, cartilage, and connective tissue. the exclusive presence of lysozyme in serous gland cells renders it useful as a biochemical marker of that cell type. measurements of lysozyme ... | 1983 | 6131743 |
| cation and atp content of ferret red cells. | ferret red cells were shown to have the following properties: 1. they have a high sodium (96 mmol/l cell) and low potassium (3.9 mmol/l cell) content. 2. the majority do not appear to have an active sodium pump in their membranes. 3. their membranes are highly permeable to rubidium indicating that they are probably also highly permeable to potassium. 4. their magnesium (3.01 mmol/l cell) and calcium (0.01 mmol/l cell) contents are similar to those of red cells from other species. 5. their atp co ... | 1983 | 6132742 |
| species differences in epinephrine concentration and norepinephrine n-methyltransferase activity in hypothalamus and brain stem. | 1. the concentration of epinephrine, norepinephrine and dopamine, and the activity of norepinephrine n-methyltransferase, the epinephrine-forming enzyme, were determined in hypothalamus and brain stem in several species. 2. epinephrine concentration in hypothalamus, a nerve terminal region, varied in the order frog greater than turtle greater than chicken greater than cat greater than dog greater than pigeon greater than rat greater than ferret greater than hamster greater than mouse, with conce ... | 1983 | 6132773 |
| species differences in the metabolic conjugation of clofibric acid and clofibrate in laboratory animals and man. | the urinary metabolites of single doses of clofibric acid (p-chlorophenoxyisobutyric acid), and its ethyl ester, clofibrate, have been investigated in rat, guinea pig, rabbit, dog, cat, ferret, and human volunteers. human volunteers, rodents, and rabbits given clofibric acid excreted 60-90% of the 14c dose in the urine in 24 hr, and the only metabolite found was the ester glucuronide of clofibric acid, together with small amounts of the unchanged acid. in the dog, cat, and ferret, however, urina ... | 1983 | 6133730 |
| continuous monitoring of the position of the ferret mandibular canine tooth to enable comparisons with the continuously-growing rabbit incisor. | a variable capacitance displacement transducer, previously employed for continuously monitoring movements of the rabbit mandibular incisor, was modified for use with the ferret mandibular canine. comparing this tooth of limited growth with the tooth of continuous growth, similarities were seen in the reactions to extrusive loads and the responses at death. for the tooth of limited growth, however, less creep was seen with extrusive loading and hexamethonium did not produce changes in tooth posit ... | 1983 | 6138020 |
| the intestine of ferret--a possible site of influenza virus replication. | anal virus shedding and stimulation of the immune response were observed in ferrets after oral and rectal administration of influenza a/hongkong/1/68 (h3n2) virus. despite of the low ph in the stomach, the virus had reached the intestines after oral administration and was found in high concentration in faeces and in mucosal cells lining the colon. using immunofluorescent staining, the virus antigen was detected in cytoplasm of columnar epithelial cells. virus replication also occurred in the res ... | 1984 | 6148853 |
| the development of the retinogeniculate pathways in normal and albino ferrets. | the retinogeniculate pathways of normal and albino ferrets have been studied with horseradish peroxidase and tritiated proline used as axonal markers. the uncrossed retinogeniculate projection of adult albino ferrets is abnormally small and occupies only a fraction of the geniculate area normally occupied by uncrossed afferents. the crossed pathway is correspondingly expanded, occupying almost the entire nucleus. the geniculate laminae in the albino ferret are abnormal, showing abnormal fusions ... | 1984 | 6151658 |
| pathology of experimental infection with brugia malayi in ferrets: comparison with occult filariasis in man. | ferrets experimentally infected with brugia malayi (subperiodic strain) developed eosinophilia at patency and usually became amicrofilaremic. ferrets necropsied within 3 months after becoming amicrofilaremic had granulomas and focal reactions to degenerating microfilariae in their livers, lungs and lymph nodes essentially identical to those of tropical eosinophilia. four of 7 ferrets that received multiple inoculations of larvae, developed edema of the inoculated paw and leg after becoming amicr ... | 1984 | 6152118 |
| antigenic and genomic analyses of influenza a(h1n1) viruses from different regions of the world, february 1978 to march 1980. | antigenic analysis of influenza a(h1n1) virus isolates by hemagglutination inhibition reactions with postinfection ferret sera and mouse monoclonal antibodies showed that, although the predominant virus in 1978 to 1979 had an a/brazil/11/78-like hemagglutinin, several new antigenic variants could be detected which differed from those identified in 1977 to 1978. most of the variants showed very minor changes and did not achieve epidemiological significance. genome analysis by ribonucleic acid-rib ... | 1981 | 6163725 |
| the relation of interferon and nonspecific inhibitors to virus levels in nasal washes of ferrets infected with influenza viruses of differing virulence. | two clones (7a, virulent; 64d, attenuated) of a recombinant influenza virus (a/pr/8/34-a/england/939/69 (h3n2)) were inactivated at the same rate by viral inhibitors present in nasal washes taken from both clone 7a- and clone 64d-infected ferrets. both clones induced similar levels of interferon in the nasal washes of infected animals. the onset and rise of interferon production occurred at the same time for both clones, and was associated with a decline in virus titres. in addition, both clones ... | 1981 | 6164382 |
| [new antigenic variants of influenza a(h1n1) virus detected in the ussr in 1979]. | studies of influenza a (h1n1) viruses isolated in the spring of 1979 in the ussr showed all the 73 strains to belong to influenza a (h1n1) virus but to be heterogeneous. apart from the strains identical with the reference a/ussr/90/77 and a/brazil/11/78 as well as intermediate ones, 14 strains were identified and found to be new drift variants. a composite analysis of representative strains of this group (a/ussr/50/79 and a/ussr/61/79) by hi test with diagnostic rat and ferret sera as well as mo ... | 1981 | 6168112 |
| mucous cells of the tracheobronchial tree in the ferret. | mucosubstances in the tracheobronchial tree of the ferret were studied histochemically. the submucous glands contained predominantly neutral mucins. scattered between these were cells containing sulphated mucins and sialidase-labile and sialidase-resistant sialomucins. most of the goblet cells in the trachea, as well as those in the bronchi and larger bronchioles, contained sulphated mucins. a smaller proportion of the goblet cells showed sialidase-labile and sialidase-resistant sialomucins. it ... | 1982 | 6175610 |
| aleutian disease in ferrets. | when 32 antibody-free ferrets were inoculated with the highly mink-virulent utah-1 strain of aleutian disease virus (adv), most developed adv antibody starting 15 days after infection, but the antibody titers were much lower than those seen in mink. relatively small amounts of adv were demonstrated in crfk cell culture, using ferret spleen and lymph node homogenates only 4 to 10 days after experimental infection, but low-level viral persistence for 180 days was shown by mink inoculation. the fer ... | 1982 | 6176546 |
| antigenic properties of some equine influenza viruses. | the antigenic relationships between the haemagglutinins of five a/equine-1 viruses and between six a/equine-2 viruses were examined using post-infection ferret and immunized pony sera. similar results were obtained with sera from both species for the a/equine-1 viruses and these confirmed minor antigenic differences between the prototype a/prague 1/56 virus and viruses isolated in england in 1973 and 1977. considerable antigenic differences were found between five of the a/equine-2 viruses, usin ... | 1982 | 6181759 |
| establishment and characterization of ferret cells in culture. | cells derived from the brain of a 6 wk-old ferret have been subcultured over 100 times and have undergone over 400 population doublings in vitro. these cells, referred to as mpf cells, have an absolute efficiency of colony formation in excess of 45%, exhibit a mean population doubling time of 12.5 h, possess ferret-specific antigens, and have isozymes with electrophoretic properties that are the same as those of isozymes found in ferret liver. the cells exhibit a cytopathic effect and support th ... | 1982 | 6185411 |
| humoral and cell-mediated immune response to influenza virus. ii. experiments in ferrets. | 1982 | 6188342 | |
| studies on pathogenicity and immunogenicity of cold adapted variants of influenza virus. | cold adapted variants of influenza virus, replicated at 37, 35, 33 and 30 degrees c, were tested for capability to multiply in ferrets and to induce h and n antibodies. virus grown at 30 degrees c differed from the other in electrophoretic mobility of its polypeptides in page, in inducing higher level of n antibodies, and in higher intensity of immunofluorescence reaction in the respiratory tract. | 1982 | 6189378 |
| persistence of visna virus in cultured ferret brain cortex and fibroblasts. | cerebral cortex tissue fragments from newborn ferrets have been cultured in vitro and, when exposed to visna virus, failed to exhibit a cytopathic effect but retained the genome of the virus in a quiescent state for 46 d before synthesizing plaque-forming virus for the subsequent 26 d. in contrast, infection of an established line of cells derived from a ferret's brain with visna virus resulted in the formation of the polykaryocytes typically produced by this virus and a limited synthesis of pla ... | 1983 | 6189779 |
| surveillance of influenza in houston, texas, usa: gradual transition from a/victoria/75 (h3n2) to a/texas/77 (h3n2) predominance and antigenic characterization of "intermediate" strains. | influenza epidemics in houston, texas, usa, during the winters of 1975-76, 1976-77, and 1977-78 were attributed to a/victoria/3/75 (h3n2), b/hong kong/5/72, and a/texas/1/77 (h3n2)-like viruses, respectively. both a/victoria and a/texas viruses were detected towards the end of the 1976-77 epidemic and throughout the 1977-78 epidemic. to determine if there had been a gradual transition in the predominant strain, 267 viral isolates from the 1975-76 epidemic were tested for a/texas virus. eight spe ... | 1983 | 6190585 |
| the early development of the av node and bundle in the ferret heart. | the development of the atrioventricular (av) junctional tissues in the ferret embryonic heart was studied on days 16, 18, and 21 of gestation. this important region of the heart was examined with pas and toluidine-blue staining at the light microscope level and with transmission electron microscopy at the ultrastructural level. by day 16 of gestation the ferret heart was in the initial stages of convolution. the heart was at the primitive four-chamber stage by 18 days postcoitum. on day 21 of ge ... | 1983 | 6192697 |
| heterogeneity of influenza b viruses. | antigenic analysis of influenza b strains isolated in 1981-82 from england, japan, and the usa, using a panel of monoclonal antibodies to the haemagglutinin of b/oregon/5/80, showed considerable heterogeneity among the isolates, the majority of which had distinct reactivity patterns. antigenically similar viruses were isolated from england, japan, and the usa, and heterogeneity was detected among isolates from each country. further studies are needed to determine whether this marked heterogeneit ... | 1983 | 6194912 |
| identification of the binding sites to monoclonal antibodies on a/ussr/90/77 (h1n1) hemagglutinin and their involvement in antigenic drift in h1n1 influenza viruses. | we have determined nucleotide sequences of the ha1 portion of the hemagglutinin (ha) gene of the parental a/ussr/90/70 (h1n1) virus and its eight variants selected in vitro with six monoclonal antibodies to study antigenic determinants. the ha1 gene of one of the variants (b-1-23) was cloned in bacteria and its nucleotide sequence was determined by the maxam-gilbert method. the nucleotide sequence of the variant was confirmed by the dideoxy chain termination method. the gene sequences of the oth ... | 1983 | 6196912 |
| immunohistochemical localization to pyloric antral g cells of peptides derived from porcine preprogastrin. | antibodies to the peptides (designated cryptic a and b) that flank the g34 region of pig progastrin were used in immunohistochemical studies of the gastrointestinal tract. in elution and restaining experiments, the same cells were revealed by the cryptic peptide antibodies, and by antibodies specific for c-terminus of g17 and n-terminus of g34. the cells reacting with the cryptic peptide antibodies were localized predominantly to antral mucosa. they were found in pig, ferret, dog and cat but not ... | 1984 | 6208575 |
| characterization of h2 influenza virus hemagglutinin with monoclonal antibodies: influence of receptor specificity. | antigenic analysis of human and avian h2 influenza viruses were done with monoclonal antibodies to the ha molecules in hemagglutination inhibition (hi) assays. these studies revealed that the receptor-binding specificity of the hemagglutinin can markedly influence the antigenic analysis obtained with monoclonal antibodies in hi tests. influenza viruses that are sensitive or resistant to inhibition by horse serum inhibitors showed marked differences in their reactivity with monoclonal antibodies ... | 1984 | 6208682 |
| steroid metabolism in the corpus luteum of the ferret. | implantation in the ferret is believed to be induced by a luteal substance which acts in concert with progesterone (p4) and which is secreted sometime between days 6 and 8 of pregnancy. this experiment was designed to identify the steroid products synthesized by ferret corpora lutea (cl) on these 2 days of pregnancy. cl were dissected from ferrets on day 6 or 8 of pregnancy and incubated with [3h] pregnenolone (p3), [3h] p4, or [3h] dehydroepiandrosterone (dhea). controls with no tissue or with ... | 1983 | 6228262 |
| steroid metabolism in corpora lutea of the western spotted skunk (spilogale putorius latifrons). | the present study reports steroid metabolism by corpora lutea (cl) obtained from skunks with diapausing embryos ('delay' cl) and with activated embryos (activated cl). cl from both reproductive periods were incubated with various radioactive precursors. control incubations without any tissue or with 50 microliter of packed skunk blood cells were also conducted simultaneously. incubation of skunk cl with [3h]-pregnenolone for 3 h resulted in 36% of the precursor accumulating as progesterone. meta ... | 1984 | 6239920 |
| experimental models for study of common respiratory viruses. | numerous epidemiological studies have shown that there is excess respiratory disease morbidity in areas of high atmospheric pollution, implying an interactive effect on the clinical illness associated with these common infections. the principal etiologic agents of human respiratory infections are respiratory syncytial virus (rsv), influenza viruses (iv), parainfluenza virus types 1 and 3 (p1, p3), adenoviruses (ad), rhinoviruses (rv) and mycoplasma pneumoniae (mpn). understanding the pathogenesi ... | 1980 | 6250807 |
| isolation of a paramyxovirus from the cerebrospinal fluid of a dog with posterior paresis. | a paramyxovirus was isolated from cerebrospinal fluid of a dog with a history of incoordination and posterior paresis. the virus apparently was not related to canine distemper virus (cdv), considering the lack of virus neutralization with cdv-specific antibody, negative immunofluorescence with cdv-specific conjugate, and avirulence for ferrets. the virus was antigenically related to a prototype strain of canine parainfluenza virus, as determined by positive immunofluorescence with canine parainf ... | 1980 | 6254938 |
| survey of virally mediated permeability changes. | 1. sendai virus causes permeability changes when added to freshly isolated brain cells (cerebellum or ependymal cells) or to a culture of forebrain cells. 2. sendai virus causes permeability changes when added to organ cultures of ferret lung or nasal turbinate. influenza virus causes no permeability changes under these conditions. 3. rabies virus and vesicular-stomatitis virus, in contrast with sendai virus, do not cause permeability changes in bhk cells or lettrée cells. 4. serum from patients ... | 1980 | 6258574 |
| [suitability of ferrets for the ibr-ipv vaccine efficacy evaluation]. | 1981 | 6274304 | |
| field and laboratory studies of equine influenza viruses isolated in 1979. | experimental ponies developed signs of disease four days after the intranasal instillation of a/england 1/79 equine influenza virus and virus was recovered from the nasopharynx from the second to the ninth day. no significant antigenic difference was found between the virus and the prototype a/miami 1/63 virus, using post infection ferret and chicken sera and post vaccination pony sera. no antigenic differences were found between four viruses isolated between january and july 1979, although some ... | 1981 | 6275599 |
| antiviral effects of single-stranded polynucleotide inhibitors of the influenza virion-associated transcriptase against influenza virus infection of hamsters and ferrets. | administration of a single-stranded polynucleotide copolymer containing 9% cytidine residues and 91% 4-thiouridine residues [poly(c,s4u10)], a known potent inhibitor of the virion transcriptase of influenza viruses, suppressed the amount of virus recoverable from the nasal washes of influenza virus-infected hamsters and ferrets. the incidence of sneezing and nasal discharge in infected ferrets was also reduced. in hamsters, poly(c,s4u10) was more effective than amantadine-hcl or virazole. polyin ... | 1981 | 6280608 |
| effects of butoprozine on ionic currents in frog atrial and ferret ventricular fibres. comparison with amiodarone and verapamil. | the effects of butoprozine on cardiac membrane currents of frog atrial and ferret ventricular fibres were investigated in voltage clamp conditions by means of the double sucrose gap technique. comparison was made with amiodarone and verapamil. butoprozine was found to decrease the fast sodium and slow calcium inward currents and the delayed outward current in a dose-dependent manner. the reactivation kinetics of both inward currents were reduced by butoprozine. amiodarone principally decreased t ... | 1982 | 6280628 |
| failure to detect hemagglutination-inhibiting antibodies with intact avian influenza virions. | avian influenza viruses replicate in a variety of mammals and birds, yet hemagglutination inhibition tests show that postinfection sera from these animals (e.g., ferrets and ducks) have insignificant levels of antibodies (hinshaw et al., infect. immun. 34:354-361, 1981). this suggested that avian influenza viruses, in contrast to mammalian viruses, may not induce a significant humoral response. studies reported here indicate that avian influenza viruses do induce high levels of antibodies in fer ... | 1982 | 6292104 |
| enhancement of calcium current during digitalis inotropy in mammalian heart: positive feed-back regulation by intracellular calcium? | 1. effects of digitalis compounds on slow inward ca current i(si)) and contractile force were examined in ferret ventricular muscle (single sucrose-gap voltage clamp) and calf purkinje fibres (two micro-electrode voltage clamp).2. in ventricular muscle, ouabain increased i(si) and inward current tails associated with i(si) conductance. the enhancement of i(si) followed a time course similar to the development of the positive inotropic effect, and it could be observed in the absence of aftercontr ... | 1982 | 6292410 |
| pulmonary alpha-adrenoceptors: autoradiographic localization using [3h]prazosin. | we determined the distribution of pulmonary alpha-adrenoceptors by autoradiographic localisation of [3h]prazosin binding to frozen sections of ferret lung. specific binding of [3h]prazosin to lung sections was saturable and of high affinity (kd = 0.44 +/- 0.55 nm; mean +/- s.e., n = 5), with a specificity indicating binding to alpha 1-receptors. autoradiographic showed that alpha 1-receptors were present in highest density in vascular smooth muscle (small vessels greater than large vessels), and ... | 1983 | 6303807 |
| diltiazem and verapamil preferentially block inactivated cardiac calcium channels. | diltiazem has been proposed to act by blocking calcium channels of cardiac and smooth muscle since it has pharmacological [12-14] and clinical [10] effects that resemble those of verapamil, an agent that has been shown to block these channels [3]. however, block of the slow inward current by diltiazem has not been directly demonstrated. in fact, it has been suggested that diltiazem has an entirely different mechanism of action [7]. we therefore studied the blocking effects of diltiazem and verap ... | 1983 | 6304329 |
| autoradiographic localization of autonomic receptors in airway smooth muscle. marked differences between large and small airways. | autoradiographic methods were used to determine the distribution of autonomic receptors in airway smooth muscle of ferret from trachea to terminal bronchioles; [3h]dihydroalprenolol, [3h]prazosin, and [3h]quinuclidinyl benzilate were used to label beta-adrenergic, alpha-adrenergic, and muscarinic receptors, respectively, using experimental conditions that gave maximal specific receptor binding. marked differences were found in the longitudinal distribution of each receptor and in distribution of ... | 1983 | 6305241 |
| neutral red stains ganglia in the vagal motor pathway to ferret trachea without affecting ganglionic transmission. | to determine the effect of neutral red (0.01%) on neural transmission through ganglia, we used an in vitro nerve-muscle preparation of ferret trachea. before, during, and after incubating the trachea in neutral red, we induced isometric muscle contractions first by activating preganglionic fibers with electrical stimulation of the vagus nerve, and then by activating postganglionic nerve fibers with electrical field stimulation. incubation in neutral red (0.01%) for 45 min at 38 degrees c reduced ... | 1983 | 6308359 |
| involvement of dopaminergic neurotransmission in the control of goal-directed movements. | changes produced in dopamine (da) activity, by administration of the da-antagonists metoclopramide (10 mg/kg im) and tiapride (16 mg/kg im) and of the da agonists apomorphine (0.5 and 1 mg/kg im) and bromocriptine (8 mg/kg orally), specifically modified predatory behavior in the ferret. sulpiride (40 mg/kg ip and 90 mg/kg im) did not change the behavior. the number of bites necessary to kill the prey was reduced by metoclopramide and tiapride. the number of bites after the death of the prey was ... | 1983 | 6312482 |
| transmission in airway ganglia of ferrets: inhibition by norepinephrine. | we examined the possibility that norepinephrine inhibits transmission in parasympathetic ganglia of the ferret trachea. we impaled ganglion cells on recording microelectrodes and evoked postsynaptic action potentials by stimulating fiber tracts entering the ganglion. when norepinephrine was added to the recording bath, the action potentials were blocked. phentolamine reversed this block. these results indicate that, by activating alpha-receptors, norepinephrine inhibits transmission in airway ga ... | 1983 | 6316214 |
| mapping of adrenergic receptors in the trachea by autoradiography. | we investigated the distribution of adrenergic receptors in ferret trachea using autoradiography. [3h]dihydroalprenolol, used to identify beta-adrenoceptors, revealed a high density of specific binding sites over surface epithelium and submucosal glands, with less labelling of smooth muscle. [3h]prazosin labelling showed that alpha 1-receptors were numerous in glands and epithelium, but sparse in smooth muscle. comparison of adrenergic receptor densities in tracheal sections from the same animal ... | 1983 | 6317370 |
| the sympathetic superior cervical ganglia as "little neuroendocrine brains". | the superior cervical ganglia (scg) provide sympathetic innervation to the pineal gland, cephalic blood vessels, the choroid plexus, the eye, carotid body and the salivary and thyroid glands. removal of the ganglia brings about several neuroendocrine changes in mammals, including the disruption of water balance in pituitary stalk-sectioned rats and the alteration of normal photoperiodic control of reproduction and thyroid function in hamsters, ferrets, voles, rams and goats. these effects are co ... | 1983 | 6324543 |
| ephaptic impulse transmission between ventricular myocardial cells in vitro. | impulse transmission between closely appositioned cylindrical myocardial preparations , from the ferret, was studied in vitro. one preparation was driven, and when the longitudinal extracellular potential difference between electrodes 80 micrometers apart was made larger than 30-60 mv by increasing the resistance of the extracellular space, ephaptic (i.e. non synaptic) impulse transmission from one preparation to another occurred. in 2 out of 8 pairs of preparations examined the impulse transmis ... | 1984 | 6331073 |
| antigenic comparisons of swine-influenza-like h1n1 isolates from pigs, birds and humans: an international collaborative study. | the objective of this international collaborative study was to compare recent swine isolates of influenza viruses and determine whether significant antigenic differences among isolates from different areas of the world could be detected. h1n1 viruses isolated from pigs, birds and humans in 12 different countries were compared in haemagglutination-inhibition assays with post-infection ferret sera and monoclonal antibodies to h1n1 strains. using a/nj/8/76 as the reference strain, we found that rec ... | 1984 | 6335845 |
| distribution of viral antigen with the lower respiratory tract of ferrets infected with a virulent influenza virus: production and release of virus from corresponding organ cultures. | using fluorescent antibody techniques, a semi-quantitative survey has been made of the distribution of influenza virus antigen in the trachea, main bronchi, and three zones (hilar, intermediate and alveolar) of all four lung lobes of ferrets following intranasal inoculation of a virulent clone (7a) of the recombinant influenza virus a/pr/8/34-a/england/939/69 (h3n2). the results confirm the indications from our previous quantitative surveys of infectious virus and histological damage in these ar ... | 1983 | 6338151 |
| studies of two novel sulfasalazine analogs, ipsalazide and balsalazide. | sulfasalazine appears to exert its beneficial effect in colitis by releasing 5-aminosalicylic acid in the colon, but its use can be limited by side effects. ipsalazide and balsalazide are novel sulfasalazine analogs designed to release 5-aminosalicylic acid and a nontoxic carrier molecule in the gastrointestinal tract. they have a low oral toxicity following single or repeat administration to mouse, rat, and ferret, and balsalazide is not mutagenic in the ames test. ipsalazide and balsalazide ar ... | 1983 | 6345112 |
| normal and abnormal appearances of the 35-day ferret fetus studied by freehand (razor blade) sections and gross examination. | this communication reports the sectioning and subsequent examination of 1-mm freehand razor blade sections of the normal 35-day ferret fetus; pregnancy in the ferret lasts for 42 days. skeletal and other abnormalities obtained after maternal treatment with teratogens, such as trypan blue, mustine hydrochloride, and sodium salicylate are included for comparison with the normal. | 1983 | 6348990 |
| pericentriolar processes of photoreceptor cell basal bodies in the mammalian retina. | pericentriolar processes (arm-like fibers) of the migrating centrioles (diplosome) in differentiating retinal photoreceptor cells were examined in six mammalian species (hamster, vole, rat, rabbit, ferret, cat). these processes emanate in a radial fashion from one end of the centrioles comprising the photoreceptor diplosome. the pericentriolar processes of the basal body are first observed as the diplosome migrates toward the apical plasmalemma, suggesting that centrioles are committed early-on ... | 1983 | 6356667 |
| clinical trials with canine distemper vaccines in exotic carnivores. | two types of killed canine distemper virus (cdv) vaccine and a modified-live cdv vaccine were clinically evaluated in four species of exotic carnivores. in 16 trials in which 13 red pandas (ailurus fulgens) were given the killed vaccine, only 1 animal had a virus-neutralization titer that exceeded 1:100. a red panda given modified-live cdv vaccine deemed safe for gray foxes and ferrets died of bacterial pneumonia 16 days later. there was no pathologic evidence of canine distemper in that panda. ... | 1983 | 6358163 |
| mastitis caused by hemolytic escherichia coli in the ferret. | hemolytic escherichia coli was isolated from the mammary glands of 8 ferrets with gangrenous mastitis. clinical signs included firm swelling of one or more mammary glands and discoloration of the overlying skin. peracute disease and acute septicemia were observed, and in some cases the animals rapidly became moribund. antibiotic therapy alone did not alter the course of the disease. wide surgical resection of the involved glands in combination with systemic antibiotic therapy (ampicillin 10 mg/k ... | 1983 | 6358164 |
| intra- and interspecific embryo transfer. | the procedures that are collectively referred to as embryo transfer (et) have many uses. they were first used as research tools to study fetal-maternal physiology. since the first successful mammalian embryo transfer in 1890, et has been utilized for enhancement of genetic selection; diagnosis and treatment of infertility; control of infectious disease transmission; screening for genetic defects; propagation of rare and endangered species; and the study of developmental biology. most of the embr ... | 1983 | 6363609 |
| the role of cellular susceptibility in the declining severity of respiratory influenza of ferrets with age. | a comparison was made, both in vivo and in organ culture, between newborn (1-day-old) and suckling (15-day-old) ferrets of lower respiratory tract tissue infected with a virulent strain (clone 7a) of influenza virus. newborn ferrets were killed by influenza virus following intranasal inoculation but suckling ferrets were almost as resistant as adult ferrets. in newborn ferrets there was a rapid, severe and progressive infection of lung tissue with infection of alveolar cells as well as those of ... | 1984 | 6365145 |
| biosynthesis of lhrh: inferences from immunocytochemical studies. | inferences regarding biosynthesis of lhrh in rats are made from immunocytochemical studies using lhrh antisera with varied and specific binding requirements. immunoreactive perikarya were observed with antisera that could bind putative large molecular weight precursors of lhrh. no cells were detected with an antiserum that requires free decapeptide terminals and could not bind extended precursors. no such differential immunoreactivity was apparent in neuronal processes and neurovascular terminal ... | 1983 | 6369270 |
| immunocytochemical localization of lhrh in the median eminence, infundibular stalk, and neurohypophysis. evidence for multiple sites of releasing hormone secretion in humans and other mammals. | the distribution of luteinizing hormone-releasing hormone (lhrh) was studied by light-microscopic immunocytochemistry in the hypothalamo-pituitary complex of humans, monkeys, ferrets, bats, and rats. lhrh-immunoreactive fibers were identified in the median eminence of all these species, but the precise location of these fibers varied. in rats, the vast majority of lhrh fibers in the median eminence was confined to the external zone. in contrast, in bats, most of the lhrh fibers were located in t ... | 1984 | 6370455 |
| suppression and enhancement of transformation of ferret peripheral blood mononuclear cells by mycobacteria. | the effect of heat killed mycobacterium bovis on the phytohaemagglutinin (pha) response of normal peripheral blood leucocytes from ferrets was dose dependent. concentrations of 10(6) organisms ml-1 and below enhanced the response, whereas more than 10(6) organisms ml-1 suppressed it. this suppression correlated with cytotoxicity of m bovis for ferret peripheral blood leucocytes. three environmental strains, m phlei, m smegmatis and m aurum were not cytotoxic and did not affect the pha response b ... | 1984 | 6379787 |
| lhrh neurons and their projections in humans and other mammals: species comparisons. | using light microscopic immunocytochemistry, we have identified lhrh neurons and their projections in humans, monkeys, ferrets, bats and rats. in all these species, lhrh neurons project to the vascular contact zone of the me, but positions of perikarya vary. this cell population, confined largely to rostral forebrain regions in rats, expands into the medial basal hypothalamus in humans, rhesus monkeys, ferrets and bats. accompanying this expansion is an augmentation of extrahypothalamic lhrh pro ... | 1984 | 6384949 |
| [intestinal influenza infection in ferrets]. | 1984 | 6397158 |