Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| proteolytic enzymes from recombinant streptomyces lividans tk24. | different proteases from the culture fluids of recombinant streptomyces lividans strains were isolated. several individual proteases were separated and characterized. a chymotrypsin-chylike activity (cla) was identified that specifically degrades a fusion protein between the alpha-amylase inhibitor from s. tendae (tendamistat, hoe467) and proinsulin from the monkey macaca fascicularis. the effective chemical inhibition of the degrading enzyme is demonstrated. | 1989 | 2693198 |
| plasma levels of sp1-like immunoreactive material (sp1) and progesterone throughout pregnancy and following ru 486-induced early abortion in the cynomolgus monkey (macaca fascicularis). | a human-sp1 immunoassay was used to detect sp1-like material (sp1) in the plasma of cynomolgus monkeys. in 27 females remaining non-pregnant during a mating period of 4 months, sp1 was occasionally detected at a mean concentration of 2.5 ng/ml. in 14 non-pregnant females of subsequent proven fertility, sp1 was detected 20 days following unfertile mating at a mean concentration of 4.8 ng/ml in 86% of cycles. at day 20 of proven pregnancies, sp1 was at 12 ng/ml in 93% of these animals. sp1 levels ... | 1989 | 2693485 |
| metabolism of dehp: effects of prefeeding and dose variation, and comparative studies in rodents and the cynomolgus monkey (cma studies). | 1989 | 2696635 | |
| aromatase inhibition by r 76713: experimental and clinical pharmacology. | r 76713 is a new non-steroidal compound which inhibits aromatase in vitro and in vivo with a potency of at least 1000-fold that of aminoglutethimide. in male cynomolgus monkeys peripheral conversion of labeled androstenedione to estrone is decreased by 85%, 4-5 h after a single intravenous dose of 0.003 mg/kg of r 76713, without altering steroid metabolic clearance rates. in rats fed a sodium-depleted diet for 3 weeks, plasma levels of aldosterone and plasma renin activity remain unchanged 2 h a ... | 1989 | 2696850 |
| renal actions of neuropeptide y in the primate. | neuropeptide y (npy) is a potent vasoconstrictor peptide contained in sympathetic nerve terminals and is co-released with norepinephrine. previous studies in the rat have suggested that npy influences renal sodium reabsorption and renin release. however, little is known about the physiological effects of npy on the kidney in the human. in the present study npy was infused intravenously and directly into the renal artery of the primate macaca fascicularis, an experimental model of the human. intr ... | 1989 | 2705532 |
| selective vagal postganglionic innervation of the sinoatrial and atrioventricular nodes in the non-human primate. | the distribution of parasympathetic postganglionic nerves to the atrioventricular (avn) and sinoatrial nodal (san) regions was investigated in the non-human primate heart. eight male monkeys (macaca fascicularis) weighing 5.5-7.0 kg. were anesthetized (alpha-chloralose, 50 mg/kg and urethane, 500 mg/kg) and instrumented to measure arterial pressure, electrocardiogram, atrial and ventricular electrograms. the cervical vagi were electrically stimulated (20 hz, 4 v, 2 ms) before and after selective ... | 1989 | 2708782 |
| urinary bladder and hindlimb afferent input inhibits activity of primate t2-t5 spinothalamic tract neurons. | 1. extracellular recordings were made from 41 spinothalamic tract (stt) neurons on the left side of the t2-t5 spinal segments of 20 monkeys (macaca fascicularis) anesthetized with alpha-chloralose. manipulation of the left triceps-chest region and electrical stimulation of cardiopulmonary sympathetic afferent fibers excited these cells. 2. isotonic urinary bladder distensions (ubd) to pressures between 20 and 80 cmh2o reduced the spontaneous activity in 33 of 41 cells. cell activity was signific ... | 1989 | 2709101 |
| topographical distribution and functional properties of cortically induced rhythmical jaw movements in the monkey (macaca fascicularis). | 1. the lateral part of the pericentral cortex of both hemispheres in three awake monkeys was explored with intracortical microstimulation (icms) using short trains (t/s; 200-microseconds pulses at 333 hz for 35 ms, less than or equal to microa) and long trains (c/s; 200-microseconds pulses at 50 hz for 3 s, less than or equal to 60 microa). in both hemispheres of one of these monkeys, the responsiveness of single cortical neurons to stimulation of the orofacial region was tested at the same intr ... | 1989 | 2709104 |
| movement characteristics of ejaculated sperm from cynomolgus monkeys (macaca fascicularis) analyzed by manual and automated computerized image analysis. | sperm motility is an important indicator of male reproductive function. an automated computerized system was used to measure the movement characteristics of cynomolgus monkey sperm. swimming velocities were in good agreement with data derived from tracking sperm heads manually with a digitizer, but sperm counting by the system was erroneous. in some ejaculates, there were two subpopulations of sperm with different curvilinear velocities, linearities of swim-paths, and lateral movements of the he ... | 1989 | 2709399 |
| establishment of the experimental conditions for inducing saccular cerebral aneurysms in primates with special reference to hypertension. | to find out the optimum experimental conditions for the induction of saccular cerebral aneurysms in primates, various procedures for inducing renal hypertension were used in cynomolgus monkeys treated with ligation of unilateral carotid artery and beta-amino-propionitrile feeding. animals were divided into four groups. in the first group, both kidneys were simultaneously compressed with a figure-eight ligation. in the second group, the kidneys were ligated at an interval of one week. in the thir ... | 1989 | 2711898 |
| toxicity of 8-methoxypsoralen in cynomolgous monkeys (macaca fascicularis). | male and female cynomolgous monkeys were administered 0, 2, 6 or 18 mg/kg 8-methoxypsoralen (8-mop) 3 times a week orally for 26 consecutive weeks. dose-dependent emesis was the most sensitive indicator of 8-mop toxicity. the lowest dose to elicit emesis was 3 x 6 mg/kg/week of 8-mop. among the histological findings proliferation of kupffer cells was the only recurring observation. however, these finding as well as some hematological and serum electrolyte changes lacked a dose-response relations ... | 1989 | 2714206 |
| [food- and water- intake, urinary and fecal output, and urinalysis in the wild-originated cynomolgus monkeys (macaca fascicularis) under the indoor individually-caged conditions]. | daily food- and water- intake, and urinary and fecal output were determined with 253 wild-originated cynomolgus monkeys kept in individual cages. in addition, urinalysis was done for freshly collected urine. a statistically significant correlation was observed between total water intake and urinary output as well as between urinary output and urinary specific gravity (p less than 0.01). | 1989 | 2714381 |
| [a survey of the prevalence of anatrichosoma sp. in nasal cavities of cynomolgus monkeys]. | microscopic examination of 45 nasal swab samples of cynomolgus monkeys revealed that three of them were positive for anatrichosoma sp. in the tissue sections of nasal mucosa collected from positive monkeys, female worms were consistently seen in the stratified squamous epithelial layer of the nasal mucosa. epithelial layer thickening and parakeratosis were evident in nasal mucosa adjacent to female worms. male worms were consistently seen in the submucosa and chronic inflammatory reactions was o ... | 1989 | 2714386 |
| noradrenergic innervation of monkey prefrontal cortex: a dopamine-beta-hydroxylase immunohistochemical study. | norepinephrine has been implicated in the regulation of a number of cortical functions, yet relatively little is known about the anatomical organization of noradrenergic axons in the expanded and highly differentiated prefrontal cortex of primates. in this study, the distribution of fibers containing dopamine-beta-hydroxylase (dbh), the enzyme that converts dopamine to norepinephrine, was characterized immunohistochemically in the prefrontal cortical regions of old world cynomolgus monkeys (maca ... | 1989 | 2715385 |
| cytoarchitectural characteristic of the frontal eye fields in macaque monkeys. | the cytoarchitecture of the prearcuate gyrus, including the region of the physiologically defined frontal eye fields (fef), was studied in four macaque monkeys (macaca fascicularis, m. mulatta) to determine if the fef could be anatomically identified. brain sections were stained with standard nissl and, in some cases, myelin stains. two nonstandard planes of section were used: one tangential to the prearcuate gyrus and the second normal to the most posterior bend of the prearcuate gyrus. the fir ... | 1989 | 2715390 |
| induction of gastric cancer in monkeys by n-methyl-n-nitro-n-nitrosoguanidine (mnng). | n-methyl-n-nitro-n-nitrosoguanidine (mnng) was administered to 9 macaca fascicularis monkeys (7 males and 2 females) through a tube at a dose of 40 mg/kg body weight 3 times a month. tumors of the pyloric part of the stomach were observed in 2 male monkeys after mnng doses of 800 and 848 mg/kg body weight, with a latent period of tumor development of 49 and 50 weeks, respectively. histologically, in one case the tumor was a solid carcinoma, and in the other it had a mixed structure showing alter ... | 1989 | 2716918 |
| comparison between measurements of maternal placental blood flow with dynamic placental scintigraphy and radioactive microspheres. | two methods for measurements of maternal placental blood flow were compared, dynamic placental scintigraphy using 113mindium and the radioactive microsphere distribution technique which was the reference method. these methods were both used before and after the blood flow was altered by a noradrenaline infusion in pregnant monkeys (macaca fascicularis). the change of the blood flow values obtained by the two methods were compared. a statistically significant correlation between the two methods w ... | 1989 | 2717547 |
| embryotoxicity studies of norfloxacin in cynomolgus monkeys: i. teratology studies and norfloxacin plasma concentration in pregnant and nonpregnant monkeys. | norfloxacin, a new orally active antibiotic, was investigated in cynomolgus monkeys for potential developmental toxicity. fifty-seven monkeys were administered a control vehicle or norfloxacin by nasogastric gavage during the major period of organogenesis on gestational days (gd) 21 through 50 at doses of 0, 50, 100, 150, or 200/300 mg/kg/day. there was no evidence of teratogenicity at any dose level. maternotoxicity and a significant increase in embryolethality occurred following doses of 200/3 ... | 1989 | 2718139 |
| functional orthopedic magnetic appliance (foma) ii--modus operandi. | a new functional appliance (fa) to correct class ii dentoskeletal malocclusions is introduced. the functional orthopedic magnetic appliance (foma) ii uses upper and lower attracting magnetic means (nd2fe14b) to constrain the lower jaw in an advanced sagittal posture. in vitro, a special gauge transducer measured the magnetic attractive path and forces. in vivo, 13 prepubertal female macaca fascicularis monkeys received facial implants and were treated for 4 months with the following appliances: ... | 1989 | 2718968 |
| from menarche to menopause: coronary artery atherosclerosis and protection in cynomolgus monkeys. | the effects on atherogenesis of stress, pregnancy, and oral contraceptive therapy were studied in a nonhuman primate model. the stress of social subordination was associated with ovarian dysfunction, unfavorable lipoprotein changes, and increased coronary artery atherosclerosis compared with nonstressed (socially dominant) or normal monkeys. although pregnant animals exhibited lower high-density lipoprotein cholesterol concentrations, they had only one half as much diet-induced coronary artery a ... | 1989 | 2719067 |
| social deprivation and coronary artery atherosclerosis in female cynomolgus monkeys. | plasma lipid concentrations and coronary artery atherosclerosis extent were compared in a retrospective study of female cynomolgus monkeys consuming a moderately atherogenic diet and housed in single cages or social groups. there was no difference between single caged and socially housed monkeys in plasma lipid concentrations. however, females housed in single cages had significantly more coronary artery atherosclerosis than those housed in social groups. it has been found previously that social ... | 1989 | 2719764 |
| blood mercury concentrations following methyl mercury exposure in adult and infant monkeys. | female monkeys (macaca fascicularis) were dosed chronically with the equivalent of 10, 25, or 50 micrograms/kg/day methyl mercury until at least 90% of estimated blood equilibrium was reached and were then bred to untreated males. infants were dosed with the same dose their mothers had received. an additional group of infants was dosed with 50 micrograms/kg/day beginning at birth. infants exposed in utero were born with higher (1.7x) mercury levels than their mothers, but blood mercury levels of ... | 1989 | 2721472 |
| potassium transport in monkey erythrocytes. | k transport in rhesus and cynomolgus monkey erythrocytes has been characterised and compared to that in human erythrocytes. transport due to the nak pump, residual (diffusional) leak, volume-, pressure- and n-ethyl-maleimide-stimulated kcl system and internal ca2+-stimulated k channel were similar to that in man but in the monkey it differed, in lacking the loop-diuretic-sensitive nakcl cotransport system. | 1989 | 2721648 |
| pattern-evoked potentials and optic nerve fiber loss in monocular laser-induced glaucoma. | erg and vep responses to counterphase checkerboard stimuli were obtained from cynomolgus monkeys with monocular glaucoma induced by laser photocoagulation of the trabecular meshwork. the glaucomatous eyes showed reductions of perg amplitude that were directly related to the histologically defined nerve damage. vep amplitudes were also reduced in the glaucomatous eyes, but were more variable and less affected by damage than the perg responses. an acute increase in eye pressure to 40 mm hg in eyes ... | 1989 | 2722446 |
| tumor necrosis factor alpha (tnf alpha) and neurological diseases. failure in detecting tnf alpha in the cerebrospinal fluid from patients with multiple sclerosis, aids dementia complex, and brain tumours. | the presence of tumor necrosis factor alpha (tnf alpha)/cachectin was investigated in 180 paired cerebrospinal fluid (csf) and serum samples from patients with neurological diseases, and in five paired csf and serum samples of macaca cynomolgus monkeys with acute monophasic experimental autoimmune encephalomyelitis (ameae). tnf alpha was never detected in human csf, even when an extensive demyelination was documented (active multiple sclerosis, acquired immunodeficiency syndrome (aids) dementia ... | 1989 | 2723041 |
| maternal factors affecting reproduction in a breeding colony of cynomolgus macaques (macaca fascicularis). | a breeding colony of cynomolgus macaques (macaca fascicularis), composed of imported and colony-born animals and established for 9 years, was evaluated for maternal factors associated with reproductive failure. the factors evaluated included age, gravidity, parity, origin, previous stillbirths, clinical incidents and type of housing. the effects of each factor on pregnancy rate (pr), stillbirth rate (sr), infant mortality rate (imr) and pregnancy success (ps) were evaluated. the overall colony r ... | 1989 | 2724919 |
| oral cavity representation at the frontal operculum of macaque monkeys. | receptive properties of neurons at areas 3 and 1-2, and the gustatory area (area g) in the frontal operculum (fop) and the neighboring areas were investigated in the cerebral cortex of macaca irus and macaca fuscata by applying mechanical and taste stimulation to the oral cavity and lips. tactile neurons with different receptive properties were noted in areas 3, 1-2 and g. areas 3 and g were packed with tongue neurons, though a considerable number of palate neurons were also found in area g, whi ... | 1989 | 2725988 |
| actions of robustoxin, a neurotoxic polypeptide from the venom of the male funnel-web spider (atrax robustus), in anaesthetized monkeys. | robustoxin, a polypeptide consisting of a chain of 42 amino acid residues in a known sequence, has been isolated by cation exchange chromatography from the crude venom of the male funnel-web spider (atrax robustus). physiological activity or toxicity in the venom fractions was detected by production of fasciculation in mouse phrenic nerve-hemidiaphragm preparations and by lethality in new-born mice. in the present experiments in macaca fascicularis monkeys anaesthetized with pentobarbitone, robu ... | 1989 | 2728033 |
| effects of rearing and exposure condition upon the acquisition of phobic behaviour in cynomolgus monkeys. | young monkeys were confronted with a harmless novel object in their familiar home-cage environment. the effects of two rearing conditions (mother and surrogate mother) and two confrontation conditions [presence and absence of the (surrogate) mother] upon the acquisition of phobic behaviour were studied. most surrogate-reared monkeys showed persistent maladaptive avoidance behaviour with respect to the object during tests, from 7 months of age onwards. most mother-reared monkeys approached the ob ... | 1989 | 2730503 |
| comparative drug metabolism of diazepam in hepatocytes isolated from man, rat, monkey and dog. | diazepam (dz) was used as a substrate in drug metabolism studies to characterise the differences in metabolite profiles in hepatocytes isolated from four species: wistar rat, cynomolgus monkey, beagle dog and man. hepatocytes were incubated with dz (20 microm) for 180 min at 3 hr post isolation in culture, and the disappearance of parent compound and appearance of its metabolites determined. dz disappearance was found to be monoexponential in rat, monkey and human cells, but that dz disappearanc ... | 1989 | 2730679 |
| behaviorally elicited heart rate reactivity and atherosclerosis in female cynomolgus monkeys (macaca fascicularis). | we previously reported that the coronary atherosclerosis of cholesterol-fed, male cynomolgus monkeys (macaca fascicularis) was exacerbated among animals that exhibited the largest heart rate (hr) reactions to a standard laboratory stressor. here we report a similar relationship between behaviorally induced hr reactivity and atherosclerosis in females of the same species. twenty-one female monkeys were fed a moderately atherogenic diet for 30 months. near the end of this period, animals were fitt ... | 1989 | 2734423 |
| successful performance by monkeys with lesions of the hippocampal formation on ab and object retrieval, two tasks that mark developmental changes in human infants. | in this study, (a) what determines success or failure on the ab and object retrieval tasks and (b) the relation between brain maturation and cognitive development as indexed by these tasks were examined. specifically, does improved performance on these tasks with age reflect maturation of memory functions dependent on the medial temporal lobe? in ab, the s watches a reward being hidden in 1 of 2 wells; after a brief delay s reaches for that reward. the ab error consists of the s continuing to re ... | 1989 | 2736067 |
| increased uveoscleral outflow as a possible mechanism of ocular hypotension caused by prostaglandin f2 alpha-1-isopropylester in the cynomolgus monkey. | the effects of topical application of a single dose of prostaglandin f2 alpha, administered as the isopropylester, on the intraocular pressure (iop), aqueous humor flow (ahf), conventional, and uveoscleral outflow were studied in cynomolgus monkeys under pentobarbital anesthesia. 1 microgram pgf2 alpha decreased the iop by 2.9 +/- 0.6 mmhg (3 hr after the application) as compared with the vehicle-treated control eye. the mean ahf during the whole experiment was slightly higher in the experimenta ... | 1989 | 2737263 |
| rate and growth pattern of cementum apposition as compared to dentine and root formation in a fluorochrome-labelled monkey (macaca fascicularis). | in the absence of data on the dynamics of cementum apposition, one female macaca fascicularis monkey, born july 1984 and sacrificed july 1985, was sequentially injected with calcein and xylenol orange 10 times, about every 33 days. following fixation in formalin, the right and left maxillary and mandibular jaw segments were embedded in mma and serially sectioned in the mesio-distal or bucco-oral directions, adapting the plane of sectioning to the various root axes. a total of 230 ground sections ... | 1989 | 2738051 |
| electrophysiological characteristics of primate spinothalamic neurons with renal and somatic inputs. | 1. spinothalamic tract (stt) neurons in the t10-l3 segments were studied for responses to renal and somatic stimuli. a total of 90 neurons was studied in 25 alpha-chloralose anesthetized monkeys (macaca fascicularis). all neurons were antidromically activated from the ventral posterior lateral nucleus of the thalamus. 2. sixty-two cells were excited by renal nerve stimulation and six inhibited. probability of locating cells with renal input was greatest in t11-l1. cells were located in laminae i ... | 1989 | 2746313 |
| coronary vascular lesions in dogs treated with phosphodiesterase iii inhibitors. | a treatment-related coronary arteriopathy has been observed in the dog following the oral or intravenous administration of 4 potent phosphodiesterase type iii inhibiting inodilators at high multiples of their ed50 for periods from 1 day to 6 months. a fifth compound of a similar pharmacological class exhibited limiting toxicity at low multiples of its ed50 and this compound failed to induce coronary arterial lesions. the earliest treatment-related findings observed were medial hemorrhage and nec ... | 1989 | 2749139 |
| teratologic potential of 2-methoxyethanol and transplacental distribution of its metabolite, 2-methoxyacetic acid, in non-human primates. | the embryotoxic effects of 2-methoxyethanol (2-me) were studied in non-human primates to better assess the risk for women of child-bearing age exposed to this agent. macaca fascicularis females were treated daily throughout the organogenetic phase of pregnancy (days 20-45) by gavage and the fetuses collected at day 100 by caesarean section. at the highest dose (0.47 mmole/kg), all eight pregnancies ended in death of the embryo. one of these dead embryos was abnormal, missing a digit on each fore ... | 1989 | 2749579 |
| effects of chronic developmental lead exposure on monkey neuroanatomy: visual system. | the effects of lead on specific areas of the visual system were examined in two groups of monkeys (macaca fascicularis). the first group (n = 3) received 2000 micrograms pb/kg/day from infancy onward, while the second group (n = 4) received 25 micrograms pb/kg/day from birth onward. monkeys were killed at approximately 6 years of age. areas of the visual system, including optic nerve, lateral geniculate nucleus, and primary area v1 and one visual projection area v2, were examined by a combinatio ... | 1989 | 2749736 |
| studies on the biotransformation of lonazolac, bromerguride, lisuride and terguride in laboratory animals and their hepatocytes. | 1. metabolic patterns and the extents of metabolism of four drugs, namely [14c]lonazolac (lon), [14c]bromerguride)bro), [14c]lisuride (lis) and [3h]terguride (ter) have been studied in three experimental models, namely hepatocyte suspensions of rat, guinea pig, beagle dog and cynomolgus monkey, isolated perfused liver of rat and guinea pig and intact animals (rat, guinea pig, dog and monkey). 2. selection of compounds was based on differences in phase i metabolic pathways. lon is exclusively hyd ... | 1989 | 2750201 |
| low-calcium, high-aluminum diet-induced motor neuron pathology in cynomolgus monkeys. | long-term epidemiological studies indicate that environmental factors play a causative role in high-incidence amyotrophic lateral sclerosis (als) and parkinsonism-dementia (pd) in the western pacific. an increased risk for disease is acquired in youth and remains for life. the low concentrations of calcium and magnesium and high levels of aluminum in the soil and drinking water, along with the relative isolation of these populations, constitute an unusual environmental feature common to all thre ... | 1989 | 2750490 |
| quantitative morphology of the central fovea in the primate retina. | electron micrograph composites of tangenital sections of the fovea centralis of three cynomolgus monkeys (macaca irus) and one baboon (papio anubis) were used to determine the spatial density of the principal retinal cells. in the center of the foveola, the density of cones ranged from 113,000 to 230,000/mm2, and pigment epithelial cells from 4,900 to 7,000/mm2. at a distance of 500 microns from the foveolar center the density of the cone cell pedicles ranged from 29,000 to 36,300/mm2, and the d ... | 1989 | 2750678 |
| fractional conversion of thromboxane a2 and b2 to urinary 2,3-dinor-thromboxane b2 and 11-dehydrothromboxane b2 in the cynomolgus monkey. | following the intravenous administration of thromboxane (tx) b2, the stable hydration product of txa2, to human and nonhuman primates the most abundant urinary metabolites are 2,3-dinor-txb2 and 11-dehydro-txb2. however, it is not known whether fractional conversion of txb2 to its enzymatic metabolites is an accurate representation of txa2 metabolism. thus, we have compared the metabolic disposition of synthetic txa2 and txb2 via the beta-oxidation and 11-oh-dehydrogenase pathways in vivo in the ... | 1989 | 2752041 |
| physiological changes during temporary occlusion of the superior vena cava in cynomolgus monkeys. | to evaluate the physiological changes that occur after temporary occlusion of the superior vena cava, we clamped the vena cava for one hour in 6 cynomolgus monkeys, monkeys with a venous system most resembling that of humans. the data from arterial blood gas analysis, ie, ph, arterial oxygen tension, arterial carbon dioxide tension, and hco3-, were within normal limits during and after occlusion of the superior vena cava. intracranial pressure was 8.6 +/- 0.8 mm hg (mean +/- standard error) befo ... | 1989 | 2757446 |
| vasa vasorum in the carotid sinus of atherosclerotic monkeys: implications for baroreceptor function. | the carotid sinus is unusually susceptible to development of severe atherosclerotic lesions. the purposes of this study were to examine effects of atherosclerosis on blood flow through vasa vasorum in the carotid sinus and to examine responses to humoral stimuli. blood flow to vasa in the carotid sinus was measured with microspheres in 8 normal and 9 atherosclerotic cynomolgus monkeys. blood flow to vasa in intima-media (in ml/min per 100 g) was 0.5 +/- 0.3 (mean +/- se) in normal and 21 +/- 5 i ... | 1989 | 2757684 |
| platelet-activating factor (paf) antagonist, web 2086, protects against paf-induced hypotension in macaca fascicularis. | 1. the actions of intravenously administered platelet-activating factor (paf) (0.1-3.33 nmol kg-1) and the effect of a recently described paf antagonist, web 2086, were investigated in the anaesthetized open-chest monkey, macaca fascicularis. 2. paf dose-dependently reduced blood pressure, left ventricular pressure (lvp) and its first differential lv dp/dt. 3. mean pulmonary artery pressure, recorded in three animals, was essentially unchanged by any dose of paf. 4. web 2086 (0.22 mumol kg-1, i. ... | 1989 | 2758235 |
| the effect of the anti-progestin ru 486 on early pregnancy in the long-tailed macaque (macaca fascicularis). | the efficacy of various doses of ru 486 in terminating pregnancy before and after the luteal-placental shift (lps) in the long-tailed macaque (macaca fascicularis) was assessed through sonographic examination and measurements of steroid hormones and their metabolites. intramuscular injection of 1.0, 2.5, 12.5, or 25.0 mg/kg was administered either from gestational day (gd) 15-18 (group 1; n = 11) or gd 23-26 (group 2; n = 9). the timing of treatment was determined by the detection of the preovul ... | 1989 | 2758841 |
| denervation of primate extraocular muscle. a unique pattern of structural alterations. | extraocular muscles differ from most other skeletal muscles in terms of constituent fiber types and innervation pattern. the rules that govern fiber responses to various experimental interventions for most skeletal muscles, therefore, may not strictly apply to the extraocular muscles. in this study, denervation of the extraocular muscles of cynomolgous monkeys, macaca fascicularis, was accomplished by intracranial transection of the oculomotor nerve. survival times of 3-167 days were allowed, an ... | 1989 | 2759804 |
| bronchoalveolar lavage cytology in cynomolgus monkeys and identification of cytologic alterations following sequential saline lavage. | total and differential cell counts were determined on cytolytic specimens obtained by fiberoptic bronchoscopy and bronchoalveolar lavage (bal) of five normal cynomolgus monkeys. total nucleated cell counts ranged from 100 to 430 cells/microliters. macrophages were approximately 91% of total nucleated cells, while lymphocytes were 3%, neutrophils 4%, and eosinophils 2% of the initial bal from each monkey. less than 1% of the cells were mast cells and ciliated or nonciliated epithelial cells. the ... | 1989 | 2763415 |
| structural adaptations of the femur and humerus to arboreal and terrestrial environments in three species of macaque. | one reason to measure cross-sectional structural properties of primate long bones is to define mechanically relevant complexes of traits that describe the adaptation of bone to different biomechanical environments. this can be effectively accomplished when congeneric species having different postural and locomotor behaviors are compared. this paper compares the cross-sectional geometry of the femur and humerus in three behaviorally different macaque species as a basis for defining such patterns. ... | 1989 | 2764087 |
| an experimental test of the theory that visual information is stored in the inferotemporal cortex. | this experiment employed reversible cold lesions to assess the possible storage functions of inferotemporal cortex (it) for visual information. four macaca fascicularis were chronically implanted with 4 bilateral sets of cryodes which covered dorsal and ventral it. animals learned visual discrimination problems while subsections of it were cooled. retention was then tested with the previously warm tissue cold as well as with all of it cold. in addition, an attempt was made to replicate previous ... | 1989 | 2765171 |
| lesions of the anterior temporal stem and the performance of delayed match-to-sample and visual discriminations in monkeys. | resection of the medial temporal lobes in humans produces an anterograde amnesia in which past memories are seemingly intact, but the ability to form new memories is compromised. efforts to reproduce these symptoms in animals have relied extensively on the delayed non-match-to-sample (dnms) and the delayed match-to-sample (dms) tasks. dnms deficits have been found with combined damage to the amygdala and hippocampus, but not to the adjacent white matter (the temporal stem) that connects the temp ... | 1989 | 2765172 |
| peptidylglycine alpha-amidating monooxygenase activity in spinal cord, dorsal roots, and dorsal root ganglia of macaca fascicularis. | several peptides synthesized by primary sensory neurons are alpha-amidated at the c-terminal residue, including vasoactive intestinal polypeptide, neurokinin a and substance p, which is also abundant in spinal cord. in pituitary and other tissues, the c-terminal amidation is catalyzed by peptidylglycine alpha-amidating monooxygenase (pam). in the present study, soluble pam activity in spinal cord and in primary sensory neurons is quantified and characterized as to cofactor and cosubstrate requir ... | 2009 | 2765892 |
| 30-day oral toxicity study of l-selenomethionine in female long-tailed macaques (macaca fascicularis). | twenty female long-tailed macaques received nasogastric intubation of 0-600 micrograms/kg-day l-selenomethionine for up to 30 consecutive days. selenium ingestion was well tolerated at all dose levels until the second to third week of the study at which time two animals given 600 micrograms/kg-day died. one animal from the 300 micrograms/kg-day group was removed from study on treatment day 19 due to selenium-induced hypothermia. in some cases, administered doses were reduced at the 300 and 600 m ... | 2009 | 2767359 |
| red nucleus of macaca fascicularis: an electron microscopic study of its synaptic organization. | the parvicellular and magnocellular divisions of the red nucleus of the old world monkey, macaca fascicularis, were analyzed at an electron microscopic level to examine the morphology of the synaptic profiles terminating on rubral neurons and to categorize them by their individual characteristics. the parvicellular division, or anterior two-thirds of the nucleus, is composed of small (10-15 microns) and medium-size (20-30 microns) cells, which are uniformly distributed with high packing density ... | 1989 | 2768554 |
| responses of primate spinothalamic tract neurons to renal pelvic distension. | 1. experiments were performed to examine responses of spinothalamic tract (stt) neurons to distension of the renal pelvis. nineteen monkeys (macaca fascicularis) were anesthetized with alpha-chloralose, paralyzed, and artificially ventilated. fifty-four stt neurons in the t11-l2 segments were studied. each cell was excited by renal nerve stimulation and had a somatic receptive field in the left flank and/or the abdomen. 2. distension of the left renal pelvis to 50 mmhg for 20-30 s increased acti ... | 1989 | 2769358 |
| human hyperimmune globulin protects against the cytotoxic action of staphylococcal alpha-toxin in vitro and in vivo. | alpha-toxin, the major cytolysin of staphylococcus aureus, preferentially attacks human platelets and cultured monocytes, thereby promoting coagulation and the release of interleukin-1 and tumor necrosis factor. titers of naturally occurring antibodies in human blood are not high enough to substantially inhibit these pathological reactions. in the present study, f(ab')2 fragment preparations from hyperimmune globulin obtained from immunized volunteers were tested for their capacity to inhibit th ... | 1989 | 2777380 |
| distribution of phenylethanolamine n-methyltransferase cell bodies, axons, and terminals in monkey brainstem: an immunohistochemical mapping study. | adrenaline (epinephrine) is an important candidate transmitter in descending spinal control systems. to date intrinsic spinal adrenergic neurons have not been reported; thus adrenergic input is presumably derived from brainstem sites. in this regard, the localization of adrenergic neurons in the brainstem is an important consideration. maps of adrenergic cell bodies and to a lesser extent axons and terminal fields have been made in various species, but not in monkeys. thus, the present study con ... | 1989 | 2778106 |
| vasopressin and oxytocin systems in the brain and upper spinal cord of macaca fascicularis. | this paper describes the vasopressin (vp) and oxytocin (oxt) immunoreactive structures in the brain and upper spinal cord of the adult male and female macaca fascicularis. immunocytochemistry following intraventricular application of colchicine displayed vp neurons in the diagonal band of broca (dbb), bed nucleus of the stria terminalis (bst), medial amygdaloid nucleus, dorsomedial hypothalamic nucleus, area of the locus coeruleus (lc), solitary tract nuclei (nts), and the dorsal horn of the cer ... | 1989 | 2778107 |
| beta-vldl metabolism by pigeon macrophages. evidence for two binding sites with different potentials promoting cholesterol accumulation. | previous studies from our laboratory (j lipid res 1988;29:643-656) have shown that thioglycolate-elicited peritoneal macrophages from white carneau and show racer pigeons, like mammalian macrophages, have on their surfaces specific receptors for acetylated low density lipoprotein (acldl) and beta-migrating very low density lipoproteins (beta-vldl). the binding kinetics of beta-vldl were complex, however, suggesting more than one binding site. the purpose of the present study was to further chara ... | 1989 | 2783080 |
| effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) on ultrastructure of nigral neuromelanin in macaca fascicularis. | in neurons of the substantia nigra (sn) of macaca fascicularis the administration of parkinsongenic doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) caused morphological changes of the neuromelanic granules. under light microscopy, the granules appeared more dispersed and larger. electron microscopy revealed coalescence of granules in large masses with loss of the electrodense component. phagocytosis of neuromelanin by glial cells was also observed. in several neurons the neuromelani ... | 1989 | 2785665 |
| drug-induced dyskinesia in primates rendered hemiparkinsonian by intracarotid administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). | the right common carotid artery was surgically exposed under general anaesthesia in 6 cynomolgus monkeys and mptp (0.5-2.2 mg/kg) directly infused. this produced a hemiparkinsonian syndrome in the contralateral limbs which responded to treatment with both levodopa and apomorphine. these drugs also precipitated dose-dependent contralateral rotation which reached a peak 2 weeks after mptp infusion. a massive depletion of large, presumably dopaminergic cells was found from the ipsilateral substanti ... | 1989 | 2786926 |
| effects of interleukin-1 on hematopoietic progenitors: evidence of stimulatory and inhibitory activities in a primate model. | the effects of recombinant human interleukin-1 rhil-1 beta (rhil-1b) on hematopoietic recovery following chemotherapy in a primate model were investigated. cynomolgus monkeys received 1 microgram/kg/day rhil-1b intravenously for 2, 7, and 14 days following 5-fluorouracil (5-fu) treatment (75 mg/kg x 2 days). compared with controls, a significantly shortened time to achieve an absolute neutrophil (anc) count over 500/microl was observed in animals receiving 2- and 7-day courses of rhil-1b (17 v 3 ... | 1989 | 2787677 |
| [a study on complement activation in cardiopulmonary bypass--experimental and clinical evaluations]. | complement activation in patients undergoing cardiopulmonary bypass (cpb) was studied, with particular reference to anaphylatoxins. complement levels were compared between a bubble oxygenator group (bog) and a membrane oxygenator group (mog). the influence of primed homologous blood on complement activation was also evaluated. c4a levels gradually increased during cpb in the bog, whereas in the mog they changed little. there was a marked initial rise of c4a levels in the bog of high h/a (primed ... | 1989 | 2788676 |
| cellular localisation of enkephalin gene expression in mptp-treated cynomolgus monkeys. | cellular sites of enkephalin gene expression were investigated using the technique of in situ hybridization in the normal striatum and in the denervated striatum of monkeys depleted of dopamine by pretreatment with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). animals received mptp by either (a) intravenous injection to induce generalized parkinsonism, or (b) infusion into one carotid artery to induce unilateral parkinsonism. the animals which received systemic injections o ... | 1989 | 2788792 |
| [the protease inhibitor system of macaques. the identification of alleles using isoelectric focusing and family analysis]. | five alpha-1-antitrypsin (alpha-1-at) phenotypes have been revealed by isoelectrofocusing (ief) in sera of 215 crab-eating macaques. alpha-1-at was monomorphic in sera of 250 rhesus monkeys. a new allele of macaque pi-system, designated as b' was postulated in addition to existing two (b and c) on the basis of ief data. the above conclusion was supported by family analysis, based on 35 monkey birth cases. alpha-1-at phenotype frequencies were in agreement with hardy-weinberg equation both in wil ... | 1989 | 2788967 |
| reversible cold lesions of the parahippocampal gyrus in monkeys result in deficits on the delayed match-to-sample and other visual tasks. | two bilateral cooling probes were placed over the parahippocampal gyrus (pg) and the cortex just dorsolateral to it, the posterior inferotemporal gyrus (p.itg) in 4 macaca fascicularis. behavioral tests included: delayed match-to-sample (dms); the acquisition and retention of single visual discriminations; the acquisition and retention of a concurrent visual discrimination task; and the retention of a spatial reversal task. during cooling of the pg and of the pg and p.itg together, there was a d ... | 1989 | 2789698 |
| magnetic resonance imaging and peripheral blood abnormalities in experimental allergic encephalomyelitis. | experimental allergic encephalomyelitis (eae) was induced in twelve cynomologous macaques (macaca fascicularis) by sensitization to autologous myelin basic protein (bp) in complete freund's adjuvant (cfa). the white blood cell (wbc) count, absolute number of lymphocytes and absolute numbers of cd4+ and cd8+ t-cell subsets were measured weekly. using magnetic resonance imaging (mri), the animals were monitored twice weekly for the development of central nervous system (cns) lesions. conventional ... | 1989 | 2790150 |
| responses of pallidal neurons to striatal stimulation in intact waking monkeys. | extracellular single-unit activity was recorded from neurons of the internal and external pallidal segments, and from 'border cells' at the periphery of the segments, in 3 waking cynomolgus monkeys during electrical stimulation of 3 sites bilaterally in the striatum: one in the caudate nucleus and two in the putamen. nearly 90% of each of the 3 types of neurons responded to at least one ipsilateral stimulation site. contralateral stimulation was much less effective, except for border neurons. ne ... | 1989 | 2790460 |
| responses of pallidal neurons to striatal stimulation in monkeys with mptp-induced parkinsonism. | extracellular single unit activity was recorded from neurons of the internal (gpi) and external (gpe) pallidal segments, and from 'border cells' (bor) which are part of the nucleus basalis, in 2 cynomolgus monkeys rendered parkinsonian by mptp (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). cell counts showed that at least 90% of the nigral neurons of the compacta-type were degenerated. electrical stimulation was applied to 3 sites bilaterally in the striatum: one in the caudate nucleus and 2 in ... | 1989 | 2790469 |
| oxygen delivery to the anterior chamber of the eye--a novel function of the anterior iris surface. | by means of po2-needle electrodes the oxygen tension in the anterior chamber of rabbit and cynomolgus monkey eyes was measured and correlated with the topography. it can be clearly shown that the po2 in front of the pupil is substantially lower than in front of the anterior iris surface. it is evident that the o2-supply of the anterior chamber is provided by the iris vasculature. this result was confirmed by measurements after partial or total iridectomy. a brief recapitulation of the morphology ... | 1989 | 2791616 |
| prostaglandin f2 alpha increases uveoscleral outflow in the cynomolgus monkey. | cynomolgus monkeys were treated topically in one eye twice daily with prostaglandin f2 alpha-l-isopropylester (pgf2 alpha-ie) for nine doses. on treatment day 4, 3 hr after the seventh dose, intraocular pressure (iop) in the treated eye was reduced by 65% compared to the controls, to less than 5 mmhg. on treatment day 5, 3 hr after the ninth dose, total outflow facility was determined by two-level constant pressure perfusion of the anterior chamber. immediately thereafter, uveoscleral outflow wa ... | 1989 | 2792235 |
| motor learning in monkeys (macaca fascicularis) with lesions in motor thalamus. | the study examines the nature of the influence that the basal ganglia exert on frontal cortex via the motor nuclei of the thalamus. twelve monkeys were trained to pull a handle given one colour cue and to turn it given another. bilateral lesions were then placed in the ventral thalamus. four monkeys with large anterior lesions including the va nucleus and the anterior part of vlo were severely impaired at relearning the task. monkeys with small lesions in vamc or with lesions centred on vlo were ... | 1989 | 2792254 |
| extrinsic determinants of retinal ganglion cell development in primates. | as in all mammals studied to date, primate retina contains morphologically distinct classes of retinal ganglion cells (polyak: the retina. chicago: university of chicago press, '41; boycott and dowling: philos. trans. r. soc. lond. [biol.] 225:109-184, '69; leventhal et al.: science 213:1139-1142, '81; perry et al.: neuroscience 12:1101-1123, '84; rodieck et al.: j. comp. neurol. 233:115-132, '85; rodieck: in h.d. steklis and j. erwin (eds): comparative primate biology, volume 4: neurosciences. ... | 1989 | 2794114 |
| pharmacological profile of mdl 26,024go: a novel antiasthmatic agent. | mdl 26,024go was shown to be an orally absorbed mediator release inhibitor in the rat pca and ppa tests. in addition, the compound was shown to both elicit and inhibit elicitation of the bezold-jarisch reflex in the dog. mdl 26,024go also significantly reduced ascaris-induced changes in pulmonary mechanics in cynomolgus monkeys. the compound inhibited both early and late phase antigen induced-changes in ascaris-sensitive sheep, as well as the increased airway hyperreactivity which normally follo ... | 1989 | 2801334 |
| anatomical brain asymmetry in monkeys: frontal, temporoparietal, and limbic cortex in macaca. | measurements evaluating possible cerebral hemispheric asymmetries were taken by hand on frontal, parietal, and temporal cortex on 60 formalin-fixed macaca mulatta and macaca fascicularis brain specimens. no statistically significant (p less than 0.05) right/left side differences in the mean length of four sulci in visual-processing areas of the cortex were found. the sulcus adjacent to the region cytoarchitecturally homologous to the motor speech area in the human brain did not show pronounced a ... | 1989 | 2801912 |
| ultrastructure of the pineal gland of the monkey, macaca fascicularis, with special reference to the presence of synaptic junctions on pinealocytes. | the present study described the normal ultrastructure of the monkey pineal gland. the gland was composed of the principal pinealocytes, intramural neurons and glial cells. the nucleus of the pinealocytes was deeply infolded with evenly distributed chromatin materials. the abundant cytoplasm was rich in organelles including the well-developed golgi apparatuses, multivesicular bodies, dense-cored vesicles and widely scattered free and polyribosomes. a variety of axon terminals was observed and the ... | 1989 | 2802179 |
| comparative anatomy of the accessory ciliary ganglion in mammals. | the orbits of 13 mammalian species (pig, sika deer, domestic sheep, horse, cat, fox, racoon dog, marten, rat, rabbit, crab-eating macaque, japanese macaque and man) were stained with silver nitrate and dissected under a dissecting microscope with special attention to the presence and location of the accessory ciliary ganglion. some preparations were stained with thionin and examined as whole-mounts in a transmission microscope. the accessory ciliary ganglion was present in all 13 species, althou ... | 1989 | 2802184 |
| reaching to a rewarded visual stimulus: interhemispheric conflict and hand use in monkeys with forebrain commissurotomy. | monkeys (macaca fascicularis) learned simultaneous visual discriminations for food reward. two coloured patterns were presented one above the other and the monkey chose one by touching it with a hand. on some trials, conflicting information was presented to the two visual hemifields. for example, in the left hemifield the stimulus associated with reward was in the higher position and in the right hemifield the stimulus associated with reward was in the lower position. on some of these conflict t ... | 1989 | 2804612 |
| primate spinothalamic cell responses to ureteral occlusion. | experiments were done to examine the effect of occlusion of the uppermost portion of the ureter on activity of spinothalamic tract (stt) neurons. fifteen monkeys (macaca fascicularis) were anesthetized with alpha-chloralose. extracellular unit recordings were obtained from 38 stt neurons in the t11-l1 segments. all cells were excited by renal a delta-afferent fibers or by both a delta- and c-fibers. in addition each cell had a somatic receptive field, most commonly located on the left flank and ... | 1989 | 2804625 |
| [body temperature of newborn cynomolgus monkeys]. | this report dealt with the change of body temperature (rectal temperature) in the newborn cynomolgus monkeys (macaca fascicularis) with a view to take it as an index for their health conditions. the body temperatures of 183 newborn babies which were well cared for by their mothers was 33.0 to 37.7 degrees c about 10 hr after birth. on the other hand, the body temperatures of 21 newborn babies which were not well cared for by their mothers was very low, ranging from 24.1 to 34.8 degrees c. in fiv ... | 1989 | 2806386 |
| the disposition and metabolism of meropenem in laboratory animals and man. | the disposition and metabolism of meropenem were studied in rats, dogs and cynomolgus monkeys following intravenous administration of [14c]-meropenem, and also in man following intravenous infusion of meropenem. following intravenous administration to rats and dogs, radioactive material was very rapidly and widely distributed in the tissues, with highest levels detected in the kidney and other highly perfused organs. concentrations in all tissues decreased rapidly with time. the plasma eliminati ... | 1989 | 2808212 |
| alveolar ridge augmentation in macaca fascicularis using polysulfone with and without demineralized bone powder. | the purpose of this study was to test the soft tissue and bone response to the implantation of porous polysulfone (ppsf) with and without demineralized bone powder (dbp) for ridge augmentation in macaca fascicularis. the mandibular molar teeth were extracted in five adult female monkeys, followed by massive alveolectomy. five to eight months later, ppsf + dbp was inserted subperiosteally on the left side, while ppsf alone was inserted on the right side. the animals were killed 42, 60, and 90 day ... | 1989 | 2809831 |
| heparin surface modified intraocular lenses implanted in the monkey eye. | the biocompatibility of heparin surface modified poly(methyl methacrylate) intraocular lenses (iols) was evaluated in two experiments following implantation in the anterior and posterior eye chambers of adult cynomolgus monkeys. throughout the study, large inflammatory cells and prominent pigment deposits were seen on the unmodified lenses, whereas the heparin surface modified iols remained almost free of precipitates. similarly, fewer posterior synechias were observed in eyes implanted with sur ... | 1989 | 2810081 |
| cocaine receptors labeled by [3h]2 beta-carbomethoxy-3 beta-(4-fluorophenyl)tropane. | the potent cocaine analog 2 beta-carbomethoxy-3 beta-(4-fluorophenyl)-tropane (cft, also designated win 35,428) was tritiated and evaluated as a molecular probe for cocaine receptors in caudate putamen membranes of cynomolgus monkeys. kinetic, saturation, and competition experiments indicated that [3h]cft, like [3h]cocaine, bound to at least two components. association and dissociation of the radioligand at 0-4 degrees occurred in two phases; the t 1/2 for dissociation of the fast and slow compo ... | 1989 | 2811854 |
| kinetics of methyl mercury in blood and brain during chronic exposure in the monkey macaca fascicularis. | the disposition parameters derived from a compartmental model kinetic analysis of blood hg levels in nonpregnant, adult female macaca fascicularis given daily doses of mehg did not vary with either dosage level (50, 70 or 90 micrograms mehg/kg b.wt.day) or duration of exposure (up to 507 day). in contrast, blood clearance of hg in pregnant females was dose-dependent; it being higher at the 90 micrograms mehg/kg b.wt.day than at the lower dosage levels. hg levels in the brain of adult fasciculari ... | 1989 | 2813296 |
| [projections of the parietal cortex on the vestibular complex in macaca]. | connections of parietal cortex (especially posterior part of area 7) with subcortical structures related with vestibular function were examined in four monkeys (macaca fascicularis), by means of anterograde labeling with hrp and tritated amino-acids tracers. posterior parietal cortex was found to have direct efferent projections onto vestibular nuclei complex and prepositus hypoglossi nucleus. these efferences were distributed bilaterally with an ipsilateral preponderance. the labeled terminals ... | 1989 | 2814161 |
| [experimental retinal branch vein occlusion]. | experimental retinal branch vein occlusion was produced in monkeys (macaca irus) by dye laser photocoagulation (yellow wavelength 577nm the 920 argon/dye laser system, coherent radiation). the clinical process was observed based on ophthalmoscopic and fluorescein angiographic alterations which occur during the natural history of experimental branch vein occlusion. immediately after occlusion, venous dilatation, retinal edema and punctate hemorrhage, were recognized by ophthalmoscopy, and leakage ... | 1989 | 2816577 |
| the role of a primate model of renal transplantation in the development of new monoclonal antibodies. | in recent years, a detailed understanding of the cellular and molecular basis of the immune response has been achieved. these advances, coupled with the technology for producing monoclonal antibodies, have made possible to consider highly specific and potentially powerful methods of immunosuppressive treatment. this promise of potent and specific treatment has not been entirely fulfilled on clinical practice. a preclinical nonhuman primate model of renal transplantation is described. the model h ... | 1989 | 2816938 |
| structure and evolution of primate cytochrome c oxidase subunit ii gene. | the sequence of cytochrome oxidase subunit ii (coii) mrna from the cynomolgus macaque has been determined. availability of the sequence from a non-human primate has allowed examination of the evolution of the coii gene and protein along the primate lineage. comparison with existing protein and dna sequences, combined with estimates of divergence derived from calculations designed to compensate for multiple mutation and reversion events, indicates that although the rate of fixation of nucleotide ... | 1987 | 2820991 |
| [hepatitis a in macaca fascicularis and m. arctoides infected by the java monkey-55 strain of hepatitis a virus]. | the results are presented dealing with experimental inoculation of m. fascicularis and m. arctoides with a strain of hepatitis a virus (hav), yam-55, isolated from a m. fascicularis with spontaneous hepatitis a, and parallel experiments on inoculation of these monkey species with hav preparations (strain has-15) obtained as a result of the strain propagation in frhk-4 cell culture and with specimens from human hepatitis a patients containing hav particles. the yam-55 strain of hav was found to b ... | 1987 | 2825433 |
| w-oxidation products of leukotriene e4 in bile and urine of the monkey. | the intravenous administration of [3h]leukotriene c4 in the monkey macaca fascicularis results in the biliary and urinary elimination of [3h]leukotriene d4 and [3h]leukotriene e4 in addition to more-polar metabolites. separation of these polar metabolites and chromatographic comparison with synthetic w-oxidized leukotrienes indicated the in vivo formation of w-hydroxy-[3h]leukotriene e4 and w-carboxy-[3h]leukotriene e4. time course studies of the [3h]leukotriene metabolite pattern in bile and ur ... | 1987 | 2825668 |
| importance of the projection from the sensory to the motor cortex for recovery of motor function following partial thalamic lesion in the monkey. | motor deficits produced by thalamic lesions were studied using adult cynomolgus monkeys. lesioned areas included n. ventralis anterior (va), ventralis lateralis (vl), n. ventralis posterolateralis pars oralis (vplo), pars caudalis (vplc) n. subthalamus (stn) and n. centrum medianum (cm). when the lesion included va, vl and vplo, there was a cerebellar syndrome, i.e., ataxia and dysmetria. when the lesion included vplo and vplc, the animal was paralyzed. when the lesion included vplo and rostral ... | 1987 | 2827861 |
| raphe nucleus of the pons containing omnipause neurons of the oculomotor system in the monkey, and its homologue in man. | omnipause neurons take part in the generation of saccadic eye movements. they lie around the midline in the caudal pontine reticular formation, in an area usually ascribed to the nucleus raphe pontis (rp). in this study of the monkey (macaca fascicularis and m. mulatta), we describe four series of experiments aimed at establishing that omnipause neurons lie within a distinctive cytoarchitectonic entity, which we call the nucleus raphe interpositus (rip): (1) cytoarchitectural study, (2) recordin ... | 1988 | 2830321 |
| pharmacokinetic and in vivo studies with azithromycin (cp-62,993), a new macrolide with an extended half-life and excellent tissue distribution. | azithromycin (cp-62,993), a new acid-stable 15-membered-ring macrolide, was well absorbed following oral administration in mice, rats, dogs, and cynomolgus monkeys. this compound exhibited a uniformly long elimination half-life and was distributed exceptionally well into all tissues. this extravascular penetration of azithromycin was demonstrated by tissue/plasma area-under-the-curve ratios ranging from 13.6 to 137 compared with ratios for erythromycin of 3.1 to 11.6. the significance of these p ... | 1987 | 2830841 |
| organization of the primate face motor cortex as revealed by intracortical microstimulation and electrophysiological identification of afferent inputs and corticobulbar projections. | 1. the technique of intracortical microstimulation (icms), supplemented by single-neuron recording, was used to carry out an extensive mapping of the face primary motor cortex. the icms study involved a total of 969 microelectrode penetrations carried out in 10 unanesthetized monkeys (macaca fascicularis). 2. monitoring of icms-evoked movements and associated electromyographic (emg) activity revealed a general pattern of motor cortical organization. this was characterized by a representation of ... | 1988 | 2835448 |
| establishment of primate lymphoblastic cell lines by coculture with a simian t-cell leukemia virus-1 positive, hypoxanthine-guanine-phosphoribosyltransferase negative japanese macaque cell line. | a cell line (jamh17+) resistant to 8-azaguanine was established from a human t-cell leukemia virus type 1 related virus (simian t-cell leukemia virus-1) positive japanese macaque cell line. lymphoblastic cell lines were established from the peripheral blood mononuclear cells of humans, hominoids, and several species of macaques by coculture with jamh17+ in hypoxanthine-aminopterin-thymidine medium. htlv-1 specific antigen was detected in some of the established cell lines. phenotypic analysis sh ... | 1988 | 2835483 |
| the antiglucocorticoid and antiprogestin steroid ru 486: its glucocorticoid agonist effect is inadequate to prevent adrenal insufficiency in primates. | the glucocorticoid receptor antagonist ru 486 has been used to treat the hypercortisolism of patients with nonpituitary cushing's syndrome. since endogenous cortisol production fluctuates in many patients with either the ectopic acth syndrome or adrenocortical tumors, treatment of these patients with a fixed dose of ru 486 introduces the risk of adrenal insufficiency. while ru 486 possesses some glucocorticoid agonist activity in addition to its potent antagonist effects, it is not known whether ... | 1988 | 2842364 |
| central projections and trigeminal ganglion location of corneal afferent neurons in the monkey, macaca fascicularis. | the method of transganglionic transport of horseradish peroxidase-wheat germ agglutinin conjugate (hrp-wga) was used to determine the location within the monkey trigeminal ganglion of the primary afferent neurons that innervate the cornea, and the brainstem and spinal cord termination sites of these cells. in each of four animals. gelfoam pledgets were saturated with 2% hrp-wga in saline and applied to the scratched surface of the central cornea for 30 minutes. postmortem examination of the corn ... | 1988 | 2843578 |
| experience in canada with the new revised monkey neurovirulence test for oral poliovirus vaccine. | nine years of experience in our laboratory, using more than 1500 cynomolgus monkeys in 138 tests, has shown that the new neurovirulence test (nvt) adopted by the world health organization (who) for live, oral monovalent vaccine of each poliovirus type, was a reproducible and sensitive assay likely to ensure the safety of this vaccine in humans. our findings were the following: (1) when the test vaccine and the appropriate homotypic reference vaccine were tested in a single group of monkeys, the ... | 1988 | 2844825 |
| soluble extracts from a lymphoblastoid cell line modulate simian immunodeficiency syndrome (saids) evolution. | nineteen macaca fascicularis monkeys were injected with siv. they were subsequently divided into 5 groups. four groups of 4 animals were injected with dialysable extracts (dle) from a lymphoblastoid cell line which had been previously induced with dle obtained either from the total lymphocyte population, or from the cd4 or cd8 subpopulations of mice immunized with siv virus. the other three animals which constituted the control group received saline injections. the animals were kept under observ ... | 1988 | 2846615 |