Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| [effects of house dust mite sublingual immunotherapy in children with allergic rhinitis and asthma]. | to evaluate the efficacy of slit with dermatophagoides farinae drops in children with allergic rhinitis and allergic asthma according to its different duration. | 2015 | 26696198 |
| [clinical efficacy and safety of rush immunotherapy in patients with allergic rhinitis]. | to evaluate the efficacy and safety of rush immunotherapy (rit) for patients with persistent allergic rhinitis (ar). | 2015 | 26696201 |
| sensitization to common aeroallergens in a population of young adults in a sub-saharan africa setting: a cross-sectional study. | sensitization to aeroallergens increases the risk of developing asthma or allergic rhinitis. data on sensitization to airborne allergens in the general population in sub-saharan africa are lacking. the aim of this study was to determine the prevalence and determinants of sensitization to common aeroallergens in a population of young adults. | 2016 | 26734065 |
| prevalence and risk factors of chronic rhinosinusitus, allergic rhinitis, and nasal septal deviation: results of the korean national health and nutrition survey 2008-2012. | chronic rhinosinusitis (crs), allergic rhinitis (ar), and nasal septal deviation (nsd) are frequent rhinologic diseases that consume considerable health care resources. | 2016 | 26747377 |
| clinical and immunological responses of dust mite sensitive, atopic dogs to treatment with sublingual immunotherapy (slit). | sublingual immunotherapy (slit) has been reported to be beneficial in people with atopic dermatitis (ad) and dust mite sensitivity. evaluation of this therapy has not been reported in spontaneous canine ad. | 2016 | 26749020 |
| proteome, allergenome, and novel allergens of house dust mite, dermatophagoides farinae. | dermatophagoides farinae mite is a predominant source of indoor allergens causing high incidence of allergy worldwide. people with different genetic background respond differently to the mite components, and thus the component-resolved diagnosis (crd) is preferred to the conventional allergy test based on crude mite extract. in this study, proteome and culprit components in the d. farinae whole body extract that sensitized the allergic patients were studied by using sds-page (1de) and 2de-ige im ... | 2016 | 26754146 |
| dose-dependent immunological responses after a 6-month course of sublingual house dust mite immunotherapy in patients with allergic rhinitis. | house dust mite (hdm) immunotherapy has proven efficacy in treating allergic rhinitis (ar) symptoms. this trial evaluated the dose-response relationship of slitoneultra® hdm mix based on immunological parameters and safety in subjects with moderate-to-severe hdm ar not controlled by symptomatic medication. | 2015 | 26789997 |
| characterization of sarcoptes scabiei cofilin gene and assessment of recombinant cofilin protein as an antigen in indirect-elisa for diagnosis. | scabies impairs the health of humans and animals and causes heavy economic losses. traditional diagnostic methods for scabies are inefficient and ineffective, and so far there is no commercial immunodiagnostic or molecular based test for scabies. | 2016 | 26801761 |
| antioxidant supplementation and exhaled nitric oxide in children with asthma. | the effect of allergen avoidance on airway inflammation is similar to that observed with treatment with inhaled steroids, whereas inhaled steroids have no effect on oxidative stress-induced inflammation. | 2016 | 26831840 |
| associations of early life exposures and environmental factors with asthma among children in rural and urban areas of guangdong, china. | environmental factors may play important roles in asthma, but findings have been inconsistent. | 2016 | 26836923 |
| the hot-water extract of smilacis chinae rhizome suppresses 2,4-dinitrochlorobenzene and house dust mite-induced atopic dermatitis-like skin lesions in mice. | smilacis chinae rhizome (scr) has been used as an oriental folk medicine for various biological activities. however, its effect on atopic dermatitis (ad) remains undetermined to date. we assessed the effect of orally administered hot-water extract of scr on ad-like skin lesions in mice and its underlying mechanisms. ad-like murine model was prepared by repeated alternate application of house dust mite (dermatophagoides farinae) extract (dfe) and 2,4-dinitrochlorobenzene (dncb) for 4 weeks, topic ... | 2016 | 26840656 |
| dust mite allergen der f 4: expression, characterization, and ige binding in pediatric asthma. | house dust mite hypersensitivity affects millions of people worldwide, and although many allergens produced by house dust mite species have been identified, some of the less potent allergens remain to be studied. | 2016 | 26842967 |
| correlation of skin test results and specific immunoglobulin e blood levels with nasal provocation testing for house-dust mite allergies. | allergen-specific immunotherapy for house-dust mite (hdm) allergies is associated with lower success rates when compared with similar treatments for other inhalant allergens, such as grass or birch. one reason might be the greater difficulty in diagnosing patients with assumed hdm allergies because symptoms occur perennially and may differ from those of a conventional allergic rhinitis. | 2016 | 26867532 |
| characterization of arginine kinase, anovel allergen of dermatophagoides farinae (der f 20). | to characterize a novel allergen, the dermatophagoides farinae-derived arginine kinase (der f 20). | 2015 | 26885278 |
| neuropeptide evolution: chelicerate neurohormone and neuropeptide genes may reflect one or more whole genome duplications. | four genomes and two transcriptomes from six chelicerate species were analyzed for the presence of neuropeptide and neurohormone precursors and their gpcrs. the genome from the spider stegodyphus mimosarum yielded 87 neuropeptide precursors and 120 neuropeptide gpcrs. many neuropeptide transcripts were also found in the transcriptomes of three other spiders, latrodectus hesperus, parasteatoda tepidariorum and acanthoscurria geniculata. for the scorpion mesobuthus martensii the numbers are 79 and ... | 2016 | 26928473 |
| [immunotherapy effect of ploypeptide vaccine of allergen group 1 from dermatophagoides farinae on asthma mice]. | to investigate the enzymatic hydrolysates of proder f land their hydrolytic products for specific immunotherapy. | 2015 | 26930933 |
| heat-killed enterococcus faecalis ef-2001 ameliorates atopic dermatitis in a murine model. | recent reports have shown the immunomodulatory effect of heat-killed lactic acid bacteria. atopic dermatitis (ad) is an allergic skin disease, caused by immune dysregulation among other factors. the aim of this study was to assess the effect of heat-killed enterococcus faecalis ef-2001 (ef-2001) on ad. we established an in vivo ad model by repeated local exposure of dermatophagoides farinae extract (dfe; house dust mite extract) and 2,4-dinitrochlorobenzene (dncb) to the ears of mice. after oral ... | 2016 | 26959058 |
| prevalence of allergic rhinitis symptoms and positive skin-prick test results in patients with dry eye. | dry eye is characterized by decreased tear production and/or increased evaporation rates of the tear film barrier. allergic rhinitis is an inflammatory disease that develops through immunoglobulin e in the rhino-ocular mucosa due to allergens. to investigate the prevalence of allergic rhinitis symptoms and positive skin-prick test results in patients with dry eye. | 2016 | 26980382 |
| the association between serum lead and total immunoglobulin e levels according to allergic sensitization. | results of several studies showed that blood lead concentration is positively associated with total immunoglobulin e (ige) value. however, no study has investigated whether allergic sensitization could be responsible for the association between lead exposure and total ige value. | 2016 | 26980386 |
| biphasic increase in scratching behaviour induced by topical application of dermatophagoides farinae extract in nc/nga mice. | atopic dermatitis (ad) is a chronic inflammatory skin disease accompanied by severe itching and eczematous lesion. in this study, we applied an ointment containing dermatophagoides farinae body (dfb) extract repeatedly on the dorsal skin of nc/nga mice with barrier disruption to investigate the characteristics of this murine model of human ad. following repeated topical application of dfb ointment twice weekly for 2 weeks, the dermatitis score increased gradually, accompanied by an elevation of ... | 2016 | 26990308 |
| stability of specific ige antibodies to common food and inhalant allergens. | to determine the optimum storage temperature for serum allergen specific ige antibodies (sige) to common food and inhalant allergens. | 2016 | 26994557 |
| perilla leaf extract prevents atopic dermatitis induced by an extract of dermatophagoides farinae in nc/nga mice. | perilla (perilla frutescens britton) leaf comprises many types of active components, mainly flavonoids, and acts as an anti-inflammatory agent in in vitro and in vivo atopic dermatitis (ad) models. | 2016 | 27001658 |
| sublingual immunotherapy (slit)--indications, mechanism, and efficacy: position paper prepared by the section of immunotherapy, polish society of allergy. | slit (sublingual immunotherapy,) induces allergen-specific immune tolerance by sublingual administration of a gradually increasing dose of an allergen. the mechanism of slit is comparable to those during scit (subcutaneous immunotherapy), with the exception of local oral dendritic cells, pre-programmed to elicit tolerance. in the slit dose, to achieve the same efficacy as in scit, it should be 50-100 times higher with better safety profile. the highest quality evidence supporting the efficacy of ... | 2016 | 27012173 |
| vitamin d supplementation during pregnancy and infancy reduces aeroallergen sensitization: a randomized controlled trial. | vitamin d has immune-modulating effects. we determined whether vitamin d supplementation during pregnancy and infancy prevents aeroallergen sensitization and primary care respiratory illness presentations. | 2016 | 27060679 |
| cellular gene expression induced by parasite antigens and allergens in neonates from parasite-infected mothers. | prenatal exposure to parasite antigens or allergens will influence the profile and strength of postnatal immune responses, such contact may tolerize and increase susceptibility to future infections or sensitize to environmental allergens. exposure in utero to parasite antigens will distinctly alter cellular gene expression in newborns. gene microarrays were applied to study gene expression in umbilical cord blood cell (ucbc) from parasite-exposed (para-pos) and non-exposed (para-neg) neonates. u ... | 2016 | 27062712 |
| identification of α-tubulin, der f 33, as a novel allergen from dermatophagoides farinae. | house dust mites are an important source of indoor allergens. more than 30 allergens of dermatophagoides farinae (d. farinae) have been identified. yet there may be many other allergens in mites remain to be characterized. | 2016 | 27067709 |
| effect of a 308-nm excimer laser on atopic dermatitis-like skin lesions in nc/nga mice. | atopic dermatitis (ad) is a common inflammatory skin disease that can affect all age groups. it has a relapsing course, which dramatically affects the quality of life of patients. a 308-nm excimer laser has been reported to be a safe and effective treatment for inflammatory skin diseases, although the range of potential application has not been fully explored. the purpose of this study was to evaluate the therapeutic effects of a 308-nm laser on ad-like skin lesions in nc/nga mice. | 2016 | 27075746 |
| forsythia suspensa fruit extracts and the constituent matairesinol confer anti-allergic effects in an allergic dermatitis mouse model. | forsythia suspensa is used in traditional medicine to treat inflammation. to clarify the anti-inflammatory and anti-allergic effects of f. suspensa fruits, we determined the therapeutic effects of crude extract, fractions, and a constituent from f. suspensa fruits on a murine atopic dermatitis (ad) model. | 2016 | 27085937 |
| [an analysis of skin prick test reactivity to dust mite in overweight and normal weight children with allergic asthma before and after specific immunotherapy]. | to study the skin prick test (spt) reactivity to house dust mite allergens in overweight and normal weight children with allergic asthma before and after standard subcutaneous specific immunotherapy. | 2016 | 27097578 |
| interleukin-4 enzyme-linked immunospot assay may be useful for diagnosing sensitization to house dust mite. | the skin prick test (spt) is considered a standard test for identification of allergens, but it has some limitations in clinical practice. the multiple allergen simultaneous test (mast), which measures allergen-specific immunoglobulin e in patients' serum, is a widely used alternative test, but is limited by its relatively low sensitivity and specificity. as a novel diagnostic test to identify allergens, we investigated the sensitivity and specificity of an interleukin-4 (il-4) enzyme-linked imm ... | 2016 | 27122253 |
| assessment of bacterial communities in thirteen species of laboratory-cultured domestic mites (acari: acaridida). | house dust mites (hdms) and stored-product mites (spms) of various species inhabit human homes and stored agricultural products. these mites are carriers and hosts of microorganisms that enable their survival. the bacteriome from 13 species of spms and hdms was analyzed and compared by 454 pyrosequencing of partial 16s rrna gene amplicons. altogether 128,052 sequences were obtained and assigned to 71 operational taxonomic units (otus) at the 97% identity level. the number of sequences in the otu ... | 2016 | 27122496 |
| characterization and analysis of a cdna coding for the group 29b (der f 29b) allergen of dermatophagoides farinae. | this study aims to acquire a recombinant allergen of der f 29b by cloning and expression, and to identify its immunogenicity. in this study, the total rna of d. farinae was extracted, cloned and expressed based on the der f 29b gene. the molecular characteristics of der f 29b was analyzed by the procedures of bioinformatics. the allergenicity of recombinant der f 29b protein was examined by western-blotting, elisa, immune inhibitory assays and skin prick test. the gene of der f 29b consisted of ... | 2016 | 27158348 |
| phosphoinositide 3-kinase δ regulates dectin-2 signaling and the generation of th2 and th17 immunity. | the c-type lectin receptor dectin-2 can trigger the leukotriene c4 synthase-dependent generation of cysteinyl leukotrienes and the caspase-associated recruitment domain 9- and nf-κb-dependent generation of cytokines, such as il-23, il-6, and tnf-α, to promote th2 and th17 immunity, respectively. dectin-2 activation also elicits the type 2 cytokine il-33, but the mechanism by which dectin-2 induces these diverse innate mediators is poorly understood. in this study, we identify a common upstream r ... | 2016 | 27194783 |
| generation and purification of monoclonal antibodies against der f 2, a major allergen from dermatophagoides farinae. | monoclonal antibodies (mabs) are needed for the quantitation of environmental allergens for precise diagnosis and immunotherapy. in this study, we produced and purified monoclonal antibodies against der f 2, one of the major allergens of the house dust mite dermatophagoides farina, in order to develop an assay for the detection of this allergen. balb/c mice were immunized four times with the protein der f 2 together with an adjuvant after which splenocytes were collected and fused with sp2/0 (my ... | 2017 | 27210892 |
| prevalence and allergen of allergic rhinitis in korean children. | in recent decades, the amount of data about allergic rhinitis (ar) in korean national health insurance service has increased. | 2016 | 27216339 |
| prenatal fish oil supplementation and allergy: 6-year follow-up of a randomized controlled trial. | evidence from randomized controlled trials in early infancy suggest that prenatal supplementation with ω-3 (n-3) long-chain polyunsaturated fatty acids (lcpufa) reduces the incidence of allergic disease characterized by an immunoglobulin e (ige) response. we aimed to determine whether protective effects were evident in the 6-year-old offspring of women supplemented with n-3 rich fish oil during pregnancy. | 2016 | 27225316 |
| house dust mite-specific sublingual immunotherapy prevents the development of allergic inflammation in a mouse model of experimental asthma. | evidence regarding sublingual immunotherapy (slit) efficacy and its good safety profile has been demonstrated with pollen and house dust mite (hdm) allergens in the treatment of airway allergies. in addition, the use of grass pollen presents a slit disease-modifying treatment for respiratory allergies. | 2016 | 27287860 |
| the effect of seasonal variations in airborne particulate matter on asthma-related airway inflammation in mice. | this study aimed to investigate the effects of winter and spring particulate matter (pm) on airway inflammation and allergies in a mouse asthma model. pm was collected during 7-28 february 2013 (winter) and during 7-28 april 2013 (spring) in yonago, japan. nc/nga mice were co-sensitized using intranasal instillation of the pms and dermatophagoides farinae (df) for 5 consecutive days, and were subsequently challenged using intranasal df at 7 days after the last sensitization. at 24 h after the ch ... | 2016 | 27294946 |
| synergistic effect of dermatophagoides farinae and lipopolysaccharides in human middle ear epithelial cells. | although the concept of "one airway, one disease," which includes the middle ear space as part of the united airway is well recognized, the role of allergens in otitis media with effusion (ome) is not clearly understood. we aimed to investigate the effect of the interaction between dermatophagoides farinae (der f) and lipopolysaccharide (lps) on the induction of epithelial inflammatory response in vitro. | 2016 | 27334783 |
| the coexistence of eosinophilic esophagitis with allergic rhinitis. | eosinophilic esophagitis (eoe) is diagnosed with the presence of characteristic esophageal symptoms and eosinophilic infiltration of the esophageal mucosa after other causes of eosinophilia are excluded. eoe has been reported to co-occur with some allergic diseases. in this study, we evaluated the co-existence of eoe in ear-nose-throat (ent) outpatient clinic patients with allergic rhinitis (ar). | 2016 | 27338057 |
| involvement of xanthine oxidoreductase-related oxidative stress in a dermatophagoides farinae-induced asthma model of nc/nga mice. | oxidative stress is widely known to play a role in asthma. however, the contribution of xanthine oxidoreductase (xor) as a source of the superoxide anion radical (o2－) in oxidative stress associated with asthma has not yet been examined in detail. here we investigated pathophysiological changes in xor in an experimental model of asthma induced by the house dust mite dermatophagoides farinae (df). in the lungs of df-treated mice, the production of o2 － from xor increased and the nitrite concentra ... | 2016 | 27339206 |
| early activation of th2/th22 inflammatory and pruritogenic pathways in acute canine atopic dermatitis skin lesions. | determining inflammation and itch pathway activation in patients with atopic dermatitis (ad) is fraught with the inability to precisely assess the age of skin lesions, thus affecting the analysis of time-dependent mediators. to characterize inflammatory events occurring during early experimental acute ad lesions, biopsy samples were collected 6, 24, and 48 hours after epicutaneous application of dermatophagoides farinae house dust mites to sensitized atopic dogs. the skin transcriptome was asses ... | 2016 | 27342734 |
| erratum: expression, purification and characterization of der f 27, a new allergen from dermatophagoides farinae. | [this corrects the article on p. 1260 in vol. 7, pmid: 26328010.]. | 2016 | 27347356 |
| 1,2,4,5-tetramethoxybenzene suppresses house dust mite-induced allergic inflammation in balb/c mice. | atopic dermatitis (ad) is the most common allergic inflammatory skin disease. the activation of innate immunity by house dust mite (dermatophagoides farinae extract, dfe) allergen plays an important role in the pathogenesis of ad. we previously showed the inhibitory effect of an extract of amomum xanthioides on allergic diseases, and isolated 1,2,4,5-tetramethoxybenzene (tmb) as a major active component. in this study, we investigated whether tmb relieves dfe-induced allergic inflammation sympto ... | 2016 | 27355819 |
| comparison between specific ige levels and skin prick test results of local and imported american cockroach, dog, cat, dust mites and mold allergen extracts. | skin prick test (spt) and specific ige (sige) are approved for evaluation of allergen sensitization. local allergen extracts are less expensive and more available but need to be standardized. | 2017 | 27362401 |
| [efficacy of sublingual immunotherapy in children with allergic rhinitis]. | to evaluate the efficacy of sublingual immunotherapy with dermatophagoides farina drops on children with allergic rhinitis. | 2016 | 27373095 |
| serum clusterin level in children with atopic dermatitis. | atopic dermatitis (ad) is a chronic inflammatory skin disease. clusterin is a sensitive cellular biosensor of oxidative stress and has been studied as a marker to assess inflammatory diseases. the clusterin levels in ad have not been evaluated thus far. | 2016 | 27401320 |
| dermatophagoides farinae allergen der f 9: cloning, expression, purification, characterization and ige-binding in children with atopic asthma. | the house dust mite species dermatophagoides farinae releases allergens that cause allergies and asthma worldwide. this study sought to clone and express the full-length cdna encoding the group 9 allergen of d. farinae (der f 9). | 2017 | 27434417 |
| high sensitization to house-dust mites in patients with allergic rhinitis in the eastern black sea region of turkey: a retrospective study. | identification of the most common aeroallergens to which patients are sensitized in a specific area is important in the diagnosis and treatment of allergic rhinitis (ar). we determined the distribution of aeroallergens, detected by skin-prick tests (spt), in adult patients with ar in the eastern black sea region of turkey and compared the results with the other regions of turkey and in the world. | 2016 | 27465310 |
| sequential epitopes of dermatophagoides farinae allergens identified using peptide microarray-based immunoassay. | house dust mites produce over 30 proteins proposed to induce immunoglobulin e (ige) antibody production in patients. continued identification of ige-binding epitopes of these allergens is critical to advancing diagnosis and treatment of allergic disease. to identify possible sequential ige-binding epitopes of the major- and mid-potency allergens from the house dust mite dermatophagoides farinae by peptide microarray-based immunoassay, nucleotide sequences of d. farinae allergens (der f) 1, 2, 4, ... | 2016 | 27481284 |
| chemical composition and inhibitory effect of lentinula edodes ethanolic extract on experimentally induced atopic dermatitis in vitro and in vivo. | the ethanolic extract of lentinula edodes was partially analyzed and then characterized for its efficacy in treating atopic dermatitis. polyphenols were determined to be the major antioxidant component in the extract (6.12 mg/g), followed by flavonoids (1.76 mg/g), β-carotene (28.75 μg/g), and lycopene (5.25 μg/g). an atopic dermatitis (ad) model was established and epidermal and dermal ear thickness, mast cell infiltration, and serum immunoglobulin levels were measured after oral administration ... | 2016 | 27483228 |
| [influence of serum levels of vitamin d on ige response in schoolchildren with asthma in poor communities]. | asthma is a common disease in the world and vitamin d (vit-d) has been associated with the presence and severity of this disease. | 2016 | 27560913 |
| different responses in induction of allergen specific immunoglobulin g4 and ige-blocking factors for three mite subcutaneous immunotherapy products. | specific immunoglobulin g4 (sigg4) and immunoglobulin e (ige)-blocking factors produced by subcutaneous immunotherapy (scit) play a critical role in the induction of allergen tolerance. however, comparative studies of available scit reagents on the induction of sigg4 are limited. we compared increases in sigg4 for three different house dust mite (hdm) scit reagents. | 2016 | 27593871 |
| theobroma cacao extract attenuates the development of dermatophagoides farinae-induced atopic dermatitis-like symptoms in nc/nga mice. | cacao beans from theobroma cacao are an abundant source of polyphenols, particularly flavonoids. previous studies demonstrated that cacao flavanols decrease pro-inflammatory cytokines resulting in the alleviation of allergic symptoms. we sought to investigate the effects of cacao extract (ce) on dermatophagoides farinae extract (dfe)-induced atopic dermatitis (ad)-like symptoms. ce attenuated dfe-induced ad-like symptoms as assessed by skin lesion analyses, dermatitis score, and skin thickness. ... | 2017 | 27596387 |
| allergic sensitization prevalence in a children and adolescent population of northeastern greece region. | to evaluate the prevalence of allergic sensitization in a childhood and adolescent population, to explore age- and gender-specific variations and finally to discover co-sensitivities among allergens. | 2016 | 27619025 |
| local allergic rhinitis in children: novel diagnostic features and potential biomarkers. | local allergic rhinitis (lar) is a phenotype of rhinitis that has been poorly studied in children. it is characterized by the same symptoms of allergic rhinitis but with the absence of markers of systemic atopy. | 2016 | 27657898 |
| immunoproteomic characterization of a dermatophagoides farinae extract used in the treatment of canine atopic dermatitis. | canine atopic dermatitis is a pruritic allergic skin disease. house dust mites have been identified as the main non-seasonal responsible agent. unlike in human allergic patients, groups 1 and 2 antigens have been described as minor allergens in dogs, while groups 15 and 18 are considered the major allergens. despite these differences, allergic dogs have traditionally been treated using extracts intended for human immunotherapy. | 2016 | 27692089 |
| is kiwifruit allergy a matter in kiwifruit-cultivating regions? a population-based study. | although kiwifruit is known as a common cause of food allergy, population-based studies concerning the prevalence of kiwifruit allergy do not exist. we aimed to determine the prevalence and clinical characteristics of ige-mediated kiwifruit allergy in 6-18-year-old urban schoolchildren in a region where kiwifruit is widely cultivated. | 2017 | 27732749 |
| topical application of moringa oleifera leaf extract ameliorates experimentally induced atopic dermatitis by the regulation of th1/th2/th17 balance. | moringa oleifera (m. oleifera) is widely cultivated in tropical and subtropical regions and has been used as a vegetable and in traditional medicine. in this study, the anti-atopic dermatitis activity of the ethanol extract of m. oleifera leaf was investigated in vitro and in vivo. | 2016 | 27744247 |
| mimotope identification of dust mite allergen der f 5 using phage‑displayed random peptide libraries. | mimotope mapping enables the characterization of allergen epitopes for the development of diagnostic and therapeutic approaches. in the present study, a phage display peptide library was used for mimotope mapping based on the binding of antibodies against the recombinant group 5 allergen from the house dust mite dermatophagoides farinae (der f 5), an arthropod that causes indoor allergies worldwide. when three monoclonal anti‑der f 5 antibodies were used for biopanning, seven mimotopes were iden ... | 2016 | 27748932 |
| variables affecting interpretation of skin prick test results. | both performer- and device-dependent variabilities have been reported in sizes of wheal responses to skin prick tests. | 2017 | 27779146 |
| association between hla genes and dust mite sensitivity in a brazilian population. | type i hypersensitivity, also known as ige-mediated allergy, is a complex, multifactorial condition whose onset and severity are influenced by both genetic and environmental factors. mite allergens stimulate the production of humoral response (ige), especially in children, which is closely involved in atopic asthma and rhinitis. | 2017 | 27780790 |
| predictors of allergen sensitization in singapore children from birth to 3 years. | immune responses in allergic diseases begin with allergen sensitization, which usually occurs in childhood. allergen sensitization involves a complex interplay of genetic and environmental factors, and sensitization patterns may change with age. | 2016 | 27799959 |
| neuropeptide evolution: chelicerate neurohormone and neuropeptide genes may reflect one or more whole genome duplications. | four genomes and two transcriptomes from six chelicerate species were analyzed for the presence of neuropeptide and neurohormone precursors and their gpcrs. the genome from the spider stegodyphus mimosarum yielded 87 neuropeptide precursors and 101 neuropeptide gpcrs. high neuropeptide transcripts were also found in the trancriptomes of three other spiders, latrodectus hesperus, parasteatoda tepidariorum and acanthoscurria geniculata. for the scorpion mesobuthus martensii the numbers are 79 and ... | 2016 | 27838380 |
| effects of asian dust particles on the early-stage antigen-induced immune response of asthma in nc/nga mice. | asian dust (ad) can aggravate airway inflammation in asthma, but the association between ad and the development of asthma remains unclear. this study aimed to investigate the effects of ad on the early stage of antigen sensitization using a mouse model of asthma, as well as the role of leukotrienes (lts) in antigen-induced airway inflammation potentiated by ad particles. nc/nga mice were co-sensitized by intranasal instillation of ad particles and/or dermatophagoides farinae (df) for five consec ... | 2016 | 27854355 |
| beneficial effects of galectin-9 on allergen-specific sublingual immunotherapy in a dermatophagoides farinae-induced mouse model of chronic asthma. | allergen-specific sublingual immunotherapy is a potential disease-modifying treatment for allergic asthma. galectin-9 (gal-9), a β-galactoside-binding protein with various biologic effects, acts as an immunomodulator in excessive immunologic reactions by expanding regulatory t cells (treg) and enhancing transforming growth factor (tgf)-β signaling. we investigated the efficacy of sublingually administered gal-9 as an adjuvant to a specific allergen in a dermatophagoides farinae (df)-induced mous ... | 2017 | 27876361 |
| allergic rhinitis, bronchial asthma and other allergies in patients with alzheimer's disease: unnoticed issue. | allergic diseases are becoming more prevalent in elderly patients. allergic diseases have been observed in patients with alzheimer's disease (ad). the prevalence of atopic bronchial asthma, allergic rhinitis and atopic dermatitis was analyzed in such elderly polish population. | 2016 | 27881942 |
| human adipose tissue-derived mesenchymal stem cells alleviate atopic dermatitis via regulation of b lymphocyte maturation. | mesenchymal stem cell (msc) has been applied for the therapy of allergic disorders due to its beneficial immunomodulatory abilities. however, the underlying mechanisms for therapeutic efficacy are reported to be diverse according to the source of cell isolation or the route of administration. we sought to investigate the safety and the efficacy of human adipose tissue-derived mscs (hat-mscs) in mouse atopic dermatitis (ad) model and to determine the distribution of cells after intravenous admini ... | 2017 | 27888809 |
| forsythia suspensa suppresses house dust mite extract-induced atopic dermatitis in nc/nga mice. | forsythia suspensa (f. suspensa) is a traditional medicine for treatment of inflammation. in this study, we evaluated the therapeutic effects of an ethanol extract from f. suspensa fruits on atopic dermatitis both in vivo and in vitro. we investigated the inhibitory effects of f. suspensa extract on the development of atopic dermatitis-like skin lesions in an nc/nga mouse model exposed to dermatophagoides farinae crude extract. topical application of f. suspensa extract to the mice attenuated th ... | 2016 | 27936051 |
| atopy patch test in children with atopic dermatitis. | atopic dermatitis is frequently associated with food and/or aeroallergen allergy. | 2016 | 27979025 |
| the natural history of atopic dermatitis and its association with atopic march. | atopic dermatitis (ad) is the first manifestation of atopic march. the natural history of ad and predictive factors for atopic march have not been widely studied in asia. | 2017 | 27996288 |
| topical ivermectin improves allergic skin inflammation. | ivermectin (ivm) is widely used in both human and veterinary medicine to treat parasitic infections. recent reports have suggested that ivm could also have anti-inflammatory properties. | 2017 | 28052336 |
| sublingual immunotherapy dosing regimens: what is ideal? | sublingual immunotherapy (slit) is a treatment for allergic respiratory diseases that has demonstrated efficacy and safety. several formulations of slit are now available worldwide for treatment of allergic rhinitis (ar). grass tablets containing 15 to 25 μg of group 5 major allergen reduced combined ar symptoms and medication use by 23% to 41% in 3 treatment years and 2 follow-up years. ragweed pollen tablets (12 μg of ambrosia artemisiifolia 1) and liquid extracts (50 μg of ambrosia artemisiif ... | 2017 | 28065336 |
| differences in therapeutic effects of topically applied corticosteroid and tacrolimus on atopic dermatitis-like symptoms in nc/nga mice. | topical corticosteroid and calcineurin inhibitor have similar therapeutic benefits in atopic dermatitis (ad), but the differences in therapeutic mechanisms of action of these agents against ad symptoms are not fully understood. | 2017 | 28069324 |
| mechanosensitive transient receptor potential vanilloid 4 regulates dermatophagoides farinae-induced airway remodeling via 2 distinct pathways modulating matrix synthesis and degradation. | contributions of mechanical signals to airway remodeling during asthma are poorly understood. transient receptor potential vanilloid 4 (trpv4), a mechanosensitive ion channel, has been implicated in cardiac and pulmonary fibrosis; however, its role in asthma remains elusive. employing a dermatophagoides farinae-induced asthma model, we report here that trpv4-knockout mice were protected from d. farinae-induced airway remodeling. furthermore, lung fibroblasts that were isolated from trpv4-knockou ... | 2017 | 28073835 |
| usefulness of house dust mite nasal provocation test in asthma. | we previously reported that the skin prick test was sensitive and the serum specific immunoglobulin e test was specific for predicting positive airway responses to house dust mites (hdms) in patients with asthma. because the nose and bronchus are one airway, the nasal provocation test would be more specific for predicting the bronchial responses to hdm than the skin test. | 2017 | 28102060 |
| intranasal azelastine and mometasone exhibit a synergistic effect on a murine model of allergic rhinitis. | the purpose of this study was to compare the anti-allergic effects of the combination of azelastine and mometasone with those of either agent alone in a dermatophagoides farinae (derf)-induced murine model of allergic rhinitis (ar). | 2017 | 28117118 |
| dry eye disease and allergic conditions: a korean nationwide population-based study. | dry eye disease (ded) is a multifactorial disease of the tears and ocular surface. no epidemiologic reports have yet been published about the relationship between ded and allergic rhinitis or sensitization to allergens. | 2016 | 28124649 |
| prevalence of house dust mites in the homes of atopic dogs in finland. | the house dust mites (hdm) dermatophagoides farinae and d. pteronyssinus are important environmental allergens implicated in the pathogenesis of human and canine atopic dermatitis. sensitization to hdm measured by allergen-specific ige is common in finnish atopic dogs. studies on hdm prevalence in finland are few but suggest that hdm are scarce. | 2017 | 28164398 |
| [skin reactivity frequency to aeroallergens in patients with clinical symptoms of allergic disease]. | allergic diseases diagnosis must be based on adequate allergological anamnesis and an immunological sensitization test; the most sensitive and specific is the skin prick test. | 2017 | 28188708 |
| [prevalence of sensitization to inhalant allergens in the immunology department from hospital de especialidades pediátricas maría, honduras, 2016]. | allergic diseases are a public health problem; estimates indicate that between 30% and 40% of the world population is affected by some allergy. knowing the prevalence of allergen sensitization allows for adequate diagnoses and treatments to be offered. in honduras there are no studies available in pediatric patients. | 2017 | 28188710 |
| [safety of subcutaneous immunotherapy with tyrosine-adsorbed house dust mite extracts in patients with allergic disease]. | in spite of allergen-specific immunotherapy (sit) multiple benefits, its use is restricted in some countries owing to concerns about severe adverse reactions. | 2018 | 28188713 |
| immediate-type allergic and protease-mediated reactions are involved in scratching behaviour induced by topical application of dermatophagoides farinae extract in nc/nga mice. | atopic dermatitis (ad)-like dermatitis can be induced by repeated topical application of an ointment containing dermatophagoides farinae body (dfb) extract in nc/nga mice. this ad-like murine model also exhibits a biphasic increase in the number of scratching behaviour after topical application of dfb ointment. in this study, we investigated the possible mechanisms underlying the scratching behaviour in each phase. an increase in the content of mast cell-derived mediators such as histamine and 5 ... | 2017 | 28191683 |
| the efficacy and safety of sublingual immunotherapy in children and adult patients with allergic rhinitis. | clinical research has shown that sublingual immunotherapy (slit) is effective and safe in moderate-severe allergic rhinitis (ar) induced by house dust mite (hdm). however, the sample size in many studies is small. meanwhile, the controversy on the efficacy and safety in the very young children younger than four years old still existed. | 2017 | 28237130 |
| accumulation of immunoglobulin g against dermatophagoides farinae tropomyosin in dorsal root ganglia of nc/nga mice with atopic dermatitis-like symptoms. | atopic dermatitis (ad), a chronic inflammatory skin disease, manifests as intractable itch, but its underlying mechanisms are poorly understood. this study assessed the relationship between immunoglobulin g (igg) and dorsal root ganglia (drg) in nc/nga mice, a model of ad that manifests ad-like symptoms including itch. immunohistochemical analysis showed large amounts of igg in drg extracts of nc/nga mice with ad-like dermatitis, with a large fraction of the igg distributed in satellite glial ce ... | 2017 | 28237704 |
| pplase of dermatophagoides farinae promotes ovalbumin-induced airway allergy by modulating the functions of dendritic cells in a mouse model. | our previous studies revealed that many proteins in addition to the known allergens of d. farinae have not been fully characterized. we observed that pplase did not respond to serum collected from patients sensitized to d. farinae. in a mouse model, pplase significantly enhanced airway hyperresponsiveness (ahr) and th2 responses induced by ovalbumin (ova) compared with mice treated with ova alone. moreover, exposure to pplase significantly increased the expression of irf4, cd80, cd83, mhcii and ... | 2017 | 28240301 |
| proof of concept of the preventive efficacy of high-dose recombinant mono-allergen immunotherapy in atopic dogs sensitized to the dermatophagoides farinae allergen der f 2. | allergen immunotherapy is currently the only intervention proposed to specifically prevent clinical flares after allergen challenges. the low molecular weight der f 2 (df2) is a major allergen in japanese dogs sensitized to dermatophagoides farinae house dust mites. | 2017 | 28261915 |
| the novel high molecular weight dermatophagoides farinae protein zen-1 is a major allergen in north american and european mite allergic dogs with atopic dermatitis. | atopic dogs with hypersensitivity to dermatophagoides farinae (df) have ige recognizing high molecular weight (mw) allergens more often than the low mw der f 1 and 2. a new high mw df allergen, zen-1, has been identified recently. | 2017 | 28261917 |
| comparative analysis of serum allergen sige detected by western blotting and fluorescent enzyme immunoassay. | various new methods to diagnose allergens have gradually developed in recent years. the present study aimed to evaluate the diagnostic performance and clinical utility of allergy-q detection system (proteometech inc., korea) on serum allergen-specific ige (sige). | 2017 | 28271691 |
| mite allergen extracts and clinical practice. | to provide physicians, researchers, and other interested health care professionals with information about how mite source materials and allergen extracts are manufactured, including the critical process parameters that can affect the final composition of allergenic extracts available for clinical use. | 2017 | 28284531 |
| a pilot study of intralymphatic immunotherapy for house dust mite, cat, and dog allergies. | several recent clinical trials reported that intralymphatic immunotherapy (ilit) for some allergens, such as cat dander and pollen, induce tolerance more rapidly than conventional subcutaneous or sublingual immunotherapy, have a comparable duration of effect after only 3 injections, and do not provoke serious local or systemic reactions. however, the efficacy and safety of ilit are using dermatophagoides farinae (df), dermatophagoides pteronyssinus (dp), and dog, which are indoor allergens that ... | 2017 | 28293934 |
| effects of ifn-γ on cell growth and the expression of adam33 gene in human embryonic lung mrc-5 fibroblasts in vitro. | to investigate the effects of interferon-γ (ifn-γ) on the proliferation and viability of human embryonic lung mrc-5 fibroblasts in vitro and the expression of the a disintegrin and metalloprotease 33 (adam33) gene and to explore the mechanism of airway remodeling. | 2018 | 28346792 |
| eucalyptus oil-loaded microcapsules grafted to cotton fabrics for acaricidal effect against dermatophagoides farinae. | the purpose of this study was to develop acaricidal cotton fabrics grafted with eucalyptus oil-loaded microcapsules (eomcs) produced from green resources. eomcs showed a broad size distribution between 0.5 and 6.5 μm, and had the average diameter 1.8 μm. eomcs exhibited nonporous spherical shapes and individually remained on cotton fibres. through aatcc mortality tests against house dust mites (hdms) (dermatophagoides farinae), the treated cotton fabric containing eomcs resulted in 98.7% mortali ... | 2017 | 28385044 |
| allergens involved in the cross-reactivity of aedes aegypti with other arthropods. | cross-reactivity between aedes aegypti and mites, cockroaches, and shrimp has been previously suggested, but the involved molecular components have not been fully described. | 2017 | 28434865 |
| der f 35: an md-2-like house dust mite allergen that cross-reacts with der f 2 and pso o 2. | dermatophagoides farinae is a source of airborne house dust mite (hdm) allergens. we elucidated ige-reactive allergens from d. farinae by two-dimensional immunoblotting-based allergenome analysis, and identified one new allergen, named der f 35, that possesses ige-binding capacity comparable to that of der f 2. the aim of this study was to clarify the allergenic capacity of new hdm allergen der f 35. | 2017 | 28439905 |
| detailed two-dimensional gel proteomic mapping of the feces of the house dust mite dermatophagoides pteronyssinus and comparison with d. farinae: reduced trypsin protease content in d. pteronyssinus and different isoforms. | major domestic mite allergens are present in feces. we present a detailed 2d-e-ms/ms proteomic analysis of the dermatophagoides pteronyssinus feces. precise cultivation yielded a pure fecal extract. we detected differences in fecal allergens/digestive enzymes between d. pteronyssinus and d. farinae using 2d-e fingerprinting, including unique information on species-specific protease isoforms. proteomic analysis was performed by 2d-e coupled with maldi-tof/tof identification. the species-specific ... | 2017 | 28442447 |
| sensitization to aspergillus species is associated with frequent exacerbations in severe asthma. | severe asthma is a largely heterogeneous disease with varying phenotypic profiles. the relationship between specific allergen sensitization and asthma severity, particularly in asia, remains unclear. we aim to study the prevalence of specific allergen sensitization patterns and investigate their association with outcomes in a severe asthma cohort in an asian setting. | 2017 | 28461762 |
| therapeutic effects of orally administered cjlp55 for atopic dermatitis via the regulation of immune response. | atopic dermatitis (ad) is an inflammatory skin condition accompanied by symptoms such as edema and hemorrhage. kimchi is a traditional fermented korean dish consisting of various probiotics. in this study, the therapeutic effect of lactobacillus plantarum cjlp55 isolated from kimchi was studied in ad-induced mice. orally administered lactobacillus strain, cjlp55, suppressed ad symptoms and high serum ige levels. cjlp55 administration reduced the thickness of the epidermis, infiltration of mast c ... | 2017 | 28461776 |
| regional difference of causative pollen in children with allergic rhinitis. | the aim of this study was to investigate role of common pollen in korean school-aged children with allergic rhinitis (ar) in 5 provinces (incheon metropolitan city-gyeonggi province, chungcheongbuk-do, gwangju metropolitan city, busan metropolitan city, and jeju special self-governing province), using a questionnaire and skin prick test, and to assess the differences among the residential regions. among the enrolled 14,678 total children, 1,641 (22.0%) had ar. the sensitization rate to pollen (3 ... | 2017 | 28480649 |
| specific immunoglobulin e and immunoglobulin g4 toward major allergens of house-dust mite during allergen-specific immunotherapy. | specific immunoglobulin e (sige) and sigg4 to house-dust mite (hdm) major allergens during allergen immunotherapy (ait) and their clinical relevance remain unclear. | 2017 | 28490399 |