Publications

microbiological zoonotic emerging risks, transmitted between livestock animals and humans (2007-2015).	as part of the emerging risk identification (eri) activities of the european food safety authority (efsa), a literature search was conducted to identify the microbiological agents transmitted between livestock animals and humans that have been suggested as having emerged between 2007 and 2015 in peer-reviewed scientific literature published during the same period (2007-2015). according to the criteria set, the search identified seven such zoonotic agents, namely west nile fever virus, rift valle ...	2017	28670863
erratum to: genome-wide analysis of an avirulent strain that induces protective immunity against challenge with virulent streptococcus suis serotype 2.		2017	28676041
bacterial bloodstream infections in a tertiary infectious diseases hospital in northern vietnam: aetiology, drug resistance, and treatment outcome.	bloodstream infections (bsis) are associated with high morbidity and mortality worldwide. however their aetiology, antimicrobial susceptibilities and associated outcomes differ between developed and developing countries. systematic data from vietnam are scarce. here we present aetiologic data on bsi in adults admitted to a large tertiary referral hospital for infectious diseases in hanoi, vietnam.	2017	28701159
serotype-specific role of antigen i/ii in the initial steps of the pathogenesis of the infection caused by streptococcus suis.	streptococcus suis is one of the most important post-weaning porcine bacterial pathogens worldwide. the serotypes 2 and 9 are often considered the most virulent and prevalent serotypes involved in swine infections, especially in europe. however, knowledge of the bacterial factors involved in the first steps of the pathogenesis of the infection remains scarce. in several pathogenic streptococci, expression of multimodal adhesion proteins known as antigen i/ii (agi/ii) have been linked with persis ...	2017	28705175
natural killer cell functions during the innate immune response to pathogenic streptococci.	dendritic cells (dcs) and nk cells play a crucial role in the first phase of host defense against infections. group b streptococcus (gbs) and streptococcus suis are encapsulated streptococci causing severe systemic inflammation, leading to septicemia and meningitis. yet, the involvement of nk cells in the innate immune response to encapsulated bacterial infection is poorly characterized. here, it was observed that these two streptococcal species rapidly induce the release of ifn-γ and that nk ce ...	2017	28706510
impact of a food safety campaign on streptococcus suis infection in humans in thailand.	abstractstreptococcus suis is an important zoonotic pathogen in swine and humans that causes sepsis and meningitis. our previous study in thailand showed that the prevalence of s. suis infection in humans, especially in northern areas of thailand, and the transmission of the pathogen occurred mainly through the consumption of traditional raw pork products. considering the high incidence proportion and mortality rate of the disease as an important public health problem, we implemented a food safe ...	2017	28719258
a positive feedback loop mediated by sigma x enhances expression of the streptococcal regulator comr.	natural transformation is used by bacteria to take up dna from their surroundings and incorporate it into their genomes. streptococci do so during a transient period of competence, triggered by pheromones that they produce, secrete and sense under conditions influenced by the environment. in streptococcus mutans, streptococcus suis, and species of the bovis, salivarius and pyogenic groups of streptococci, the pheromone xip is sensed by the intra-cellular regulator comr, that in turn activates th ...	2017	28729683
seven new lignan glycosides from the branches of alangium kurzii craib var. laxifolium.	seven new lignan glycosides (1-3, 8-10, and 14) and 17 known compounds were isolated from the branches of alangium kurzii craib var. laxifolium. their structures were established by spectroscopic analysis and circular dichroism (cd) and x-ray analysis. the isolated compounds were evaluated for their antibacterial activities against staphylococcus aureus ci1011, streptococcus suis ci1608, salmonella gallinarum ci0912, enterococcus faecalis ci1304, aeromonas hydrophila ci1008, escherichia coli ci1 ...	2017	28733150
sub-minimum inhibitory concentrations of rhubarb water extracts inhibit streptococcus suis biofilm formation.	streptococcus suis is one of the most important swine pathogens, which can cause persistent infection by forming biofilms. in this study, sub-minimum inhibitory concentration (sub-mic) of rhubarb water extracts were found to inhibit biofilm formation. two-component signal transduction systems (tcss), transcriptional regulators, and dna binding proteins were compared under two conditions: (1) cells treated with sub-mic rhubarb water extracts and (2) untreated cells. using an isobaric tags for rel ...	2017	28736523
the bias of experimental design, including strain background, in the determination of critical streptococcus suis serotype 2 virulence factors.	streptococcus suis serotype 2 is an important porcine bacterial pathogen and emerging zoonotic agent mainly responsible for sudden death, septic shock, and meningitis. however, serotype 2 strains are genotypically and phenotypically heterogeneous. though a multitude of virulence factors have been described for s. suis serotype 2, the lack of a clear definition regarding which ones are truly "critical" has created inconsistencies that have only recently been highlighted. herein, the involvement o ...	2017	28753679
patterns of antimicrobial resistance in streptococcus suis isolates from pigs with or without streptococcal disease in england between 2009 and 2014.	antimicrobial resistance in streptococcus suis, a global zoonotic pathogen of pigs, has been mostly studied only in diseased animals using surveys that have not evaluated changes over time. we compared patterns of resistance between s. suis isolates from clinical cases of disease (cc) and non-clinical case (ncc) pigs in england, collected over two discrete periods, 2009-2011 and 2013-2014. minimum inhibitory concentrations (mic) of 17 antimicrobials (nine classes) were determined on 405 s. suis ...	2017	28757010
characterization of a novel streptococcal heme-binding protein snta and its interaction with host antioxidant protein aop2.	efficient iron acquisition is critical for bacteria's survival, virulence and pathology of diseases. the largest reservoir of iron in mammals is incorporated into heme, which can be acquired by bacterial pathogens as a nutritional iron source. in this study, a cell wall protein snta of streptococcus suis serotype 2 (ss2) was characterized as a novel heme-binding protein by using the pyridine hemochrome assay and icp-ms measurement. yeast two-hybrid and pull-down assays revealed that the snta pro ...	2017	28823793
hp1330 contributes to streptococcus suis virulence by inducing toll-like receptor 2- and erk1/2-dependent pro-inflammatory responses and influencing in vivo s. suis loads.	streptococcus suis 2 (ss2) has evolved into a highly invasive pathogen responsible for two large-scale outbreaks of streptococcal toxic shock-like syndrome (stsls) in china. excessive inflammation stimulated by ss2 is considered a hallmark of stsls, even it also plays important roles in other clinical symptoms of ss2-related disease, including meningitis, septicemia, and sudden death. however, the mechanism of ss2-caused excessive inflammation remains poorly understood. here, a novel pro-inflamm ...	2017	28824616
defining the taxonomic status of streptococcus suis serotype 33: the proposal for streptococcus ruminantium sp. nov.	to clarify the taxonomic classification of streptococcus suis serotype 33, we performed biochemical and molecular genetic analyses using isolates (gut-183, gut-184, gut-185, gut-186, gut-187t, gut-188, gut-189, gut-190, gut-191, gut-192 and gut-193) from bovine endocarditis. a comparative sequence analysis showed 99.2-100 % sequence similarity among the reference strain of s. suis serotype 33 and our isolates for the 16s rrna gene. these similarities were higher than those between the isolate gu ...	2017	28840807
hsds, belonging to the type i restriction-modification system, contributes to the streptococcus suis serotype 2 survival ability in phagocytes.	streptococcus suis serotype 2 (ss2) is an important zoonotic agent in swine and humans. anti-phagocytosis and survival in phagocytic cells and whole blood is essential for bacteria to be pathogenic. in this study, the host specificity determinant specificity subunit (coded by hsds) of the type i restriction-modification system and two peptidoglycan-binding proteins (coded by lysm and lysm', respectively), which were simultaneously found to be subjected to transcript-level influence by hsds, were ...	2017	28848531
activation of invariant natural killer t cells stimulated with microbial α-mannosyl glycolipids.	some synthetic and bacterial glycolipids presented by cd1d specifically activate invariant nkt (inkt) cells bearing an invariant vα14-jα18 (mouse) or vα24-jα18 (human) tcr. the antigenic glycolipids identified to date consist of two hydrophobic chains and an α-glycoside in which the 2'-oh group is in the cis orientation toward the anomeric group, namely, either an α-galactoside or an α-glucoside. several microbial α-mannosyl glycolipids, in which the 2'-oh group is in the trans orientation, were ...	2017	28852174