Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| borrelia burgdorferi sensu lato and spotted fever group rickettsiae in small rodents and attached ticks in the northern apennines, italy. | ticks and ear biopsies were collected from wild small rodents in 2011 and 2012 in the northern apennines (italy), up to 1650 m above sea level. apodemus spp. (n = 83) and myodes glareolus (n = 22) were infested by ixodes ricinus (192 larvae and two nymphs), dermacentor marginatus (179 larvae and 29 nymphs), and ixodes trianguliceps (three larvae and two nymphs). we detected several borrelia burgdorferi sensu lato (s.l.) genospecies (b. afzelii, b. burgdorferi sensu stricto, b. garinii, b. lusita ... | 2019 | 31014939 |
| identifying the patterns and drivers of puumala hantavirus enzootic dynamics using reservoir sampling. | hantaviruses are zoonotic hemorrhagic fever viruses for which prevention of human spillover remains the first priority in disease management. tailored intervention measures require an understanding of the drivers of enzootic dynamics, commonly inferred from distorted human incidence data. here, we use longitudinal sampling of approximately three decades of puumala orthohantavirus (puuv) evolution in isolated reservoir populations to estimate puuv evolutionary rates, and apply these to study the ... | 2019 | 31024739 |
| susceptibility to infection with borrelia afzelii and tlr2 polymorphism in a wild reservoir host. | the study of polymorphic immune genes in host populations is critical for understanding genetic variation in susceptibility to pathogens. controlled infection experiments are necessary to separate variation in the probability of exposure from genetic variation in susceptibility to infection, but such experiments are rare for wild vertebrate reservoir hosts and their zoonotic pathogens. the bank vole (myodes glareolus) is an important reservoir host of borrelia afzelii, a tick-borne spirochete th ... | 2019 | 31040326 |
| analysis of the integrin β3 receptor for pathogenic orthohantaviruses in rodent host species. | host reservoir specificity of pathogens is complex and may depend on receptor variability. for pathogenic orthohantaviruses, integrin β3 had been previously identified as entry receptor and the presence of aspartic acid residue at position 39 (d39) in human integrin β3 was described to be a prerequisite for infection of primate cells with hantaan virus (htnv). however, the role of integrin β3 in orthohantavirus infection of host animals is not completely understood. therefore, we analyzed the nu ... | 2019 | 31054291 |
| how general are generalist parasites? the small mammal part of the lyme disease transmission cycle in two ecosystems in northern europe. | the pathogens causing lyme disease are all vectored by generalist tick species found on a wide range of vertebrates, but spatial and annual variation in host use has rarely been quantified. we here compare the load of ixodes ricinus (the vector) on small mammals and investigate the infection prevalence of borrelia burgdorferi s.l. (the pathogen) involved in the enzootic transmission cycle of lyme disease in two contrasting ecosystems in norway from 2014 to 2016. the most common larval tick host ... | 2019 | 31062166 |
| do phase-dependent life history traits in cyclic voles persist in a common environment? | phenotype and life history traits of an individual are a product of environmental conditions and the genome. environment can be current or past, which complicates the distinction between environmental and heritable effects on the phenotype in wild animals. we studied genome-environment interactions on phenotype and life history traits by transplanting bank voles (myodes glareolus) from northern and southern populations, originating from low or high population cycle phases, to common garden condi ... | 2019 | 31065806 |
| the role of juvenile dermacentor reticulatus ticks as vectors of microorganisms and the problem of 'meal contamination'. | juvenile dermacentor reticulatus ticks inhabit nests and burrows of their rodent hosts and cannot be collected from vegetation. to detect vertical transmission of babesia canis in d. reticulatus, we studied larvae and nymphs collected from rodents. however, the molecular techniques used for detection of pathogen dna are sensitive enough to detect not only pathogens vectored by ticks but also those taken up with current or previous blood meals ('meal contamination') or just present in the environ ... | 2019 | 31119415 |
| molecular survey of babesia microti (aconoidasida: piroplasmida) in wild rodents in turkey. | babesia microti (aconoidasida: piroplasmida) (franca, 1910) is an important tick-borne zoonotic parasite with rodents serving as reservoir hosts. in the present study, 536 rodents were captured from burdur, bartin, giresun, and yozgat provinces of turkey between the years 2010 and 2012, and blood samples were examined for the presence of babesia spp. using conventional pcr which targeted the 18s rrna gene. the sequence analysis of pcr amplicons was tested for b. microti as well as for hepatozoon ... | 2019 | 31143936 |
| intergenerational fitness effects of the early life environment in a wild rodent. | the early life environment can have profound, long-lasting effects on an individual's fitness. for example, early life quality might (a) positively associate with fitness (a silver spoon effect), (b) stimulate a predictive adaptive response (by adjusting the phenotype to the quality of the environment to maximize fitness) or (c) be obscured by subsequent plasticity. potentially, the effects of the early life environment can persist beyond one generation, though the intergenerational plasticity o ... | 2019 | 31162628 |
| is experimental evolution of an increased aerobic exercise performance in bank voles mediated by endocannabinoid signaling pathway? | the level of physical activity achieved in a given situation depends on both physiological abilities and behavioral characteristics (motivation). we used a unique animal model to test a hypothesis that evolution of an increased aerobic exercise performance can be facilitated by evolution of motivation to undertake physical activity, mediated by brain endocannabinoid system. bank voles (myodes glareolus) from "aerobic" a lines selected for 22 generations for high swim-induced aerobic metabolism ( ... | 2019 | 31191344 |
| seroprevalence of trichinella spp. infection in bank voles (myodes glareolus) - a long term study. | rodents play an important role as reservoir hosts of zoonotic diseases. as a component of our long-term programme of monitoring parasitic infections in bank vole populations in three ecologically similar sites in ne poland, we screened blood samples for signs of a serological response to the presence of trichinella spp. the overall seroprevalence of trichinella spp. was 1.52%, but prevalence was largely concentrated in one of our three study sites and confined to the oldest individuals in the st ... | 2019 | 31193257 |
| consistent within-group covariance of septal and temporal hippocampal neurogenesis with behavioral phenotypes for exploration and memory retention across wild and laboratory small rodents. | striking differences in the septo-temporal distribution of neurogenesis are found in small rodents. here, we assessed the association of adult hippocampal neurogenesis with behavioral responses to novelty, temporal and spatial sequence and reversal learning in wild, wild-derived and laboratory rodents using an automated testing apparatus, the intellicage. behaviorally, dba/2 and wild-derived house mice were quickest to explore a novel environment, wild wood mice and bank voles were slowest, and ... | 2019 | 31201873 |
| light pollution affects space use and interaction of two small mammal species irrespective of personality. | artificial light at night (alan) is one form of human-induced rapid environmental changes (hirec) and is strongly interfering with natural dark-light cycles. some personality types within a species might be better suited to cope with environmental change and therefore might be selected upon under ongoing urbanization. | 2019 | 31215409 |
| cytokine storm combined with humoral immune response defect in fatal hemorrhagic fever with renal syndrome case, tatarstan, russia. | hemorrhagic fever with renal syndrome (hfrs) is endemic in tatarstan, where thousands of cases are registered annually. puumalaorthohantavirus is commonly detected in human case samples as well as in captured bank voles, the rodent hosts. the pathogenesis of hfrs is still not well described, although the cytokine storm hypothesis is largely accepted. in this study, we present a comprehensive analysis of a fatal hfrs case compared with twenty four non-fatal cases where activation of the humoral a ... | 2019 | 31269734 |
| individual variation in cognitive style reflects foraging and anti-predator strategies in a small mammal. | balancing foraging gain and predation risk is a fundamental trade-off in the life of animals. individual strategies to acquire, process, store and use information to solve cognitive tasks are likely to affect speed and flexibility of learning, and ecologically relevant decisions regarding foraging and predation risk. theory suggests a functional link between individual variation in cognitive style and behaviour (animal personality) via speed-accuracy and risk-reward trade-offs. we tested whether ... | 2019 | 31300696 |
| serologic survey of the crimean-congo haemorrhagic fever virus infection among wild rodents in hungary. | crimean-congo haemorrhagic fever virus (cchfv) is a tick-borne pathogen, which causes an increasing number of severe infections in many parts of africa, asia and in europe. the virus is primarily transmitted by ticks, however, the spectrum of natural hosts regarding cchfv includes a wide variety of domestic and wild animals. although the presence of cchfv was hypothesized in hungary, data in support of cchfv prevalence has thus far, proven insufficient. in the present study, rodents belonging to ... | 2019 | 31302067 |
| population dynamics of bank voles predicts human puumala hantavirus risk. | predicting risk of zoonotic diseases, i.e., diseases shared by humans and animals, is often complicated by the population ecology of wildlife host(s). we here demonstrate how ecological knowledge of a disease system can be used for early prediction of human risk using puumala hantavirus (puuv) in bank voles (myodes glareolus), which causes nephropathia epidemica (ne) in humans, as a model system. bank vole populations at northern latitudes exhibit multiannual fluctuations in density and spatial ... | 2019 | 31309365 |
| zoonotic virus seroprevalence among bank voles, poland, 2002-2010. | bank voles in poland are reservoirs of zoonotic viruses. to determine seroprevalence of hantavirus, arenavirus, and cowpox virus and factors affecting seroprevalence, we screened for antibodies against these viruses over 9 years. cowpox virus was most prevalent and affected by extrinsic and intrinsic factors. long-term and multisite surveillance is crucial. | 2019 | 31310209 |
| exploring the reservoir hosts of tick-borne encephalitis virus. | tick-borne encephalitis virus (tbev) is an important arbovirus, which is found across large parts of eurasia and is considered to be a major health risk for humans. like any other arbovirus, tbev relies on complex interactions between vectors, reservoir hosts, and the environment for successful virus circulation. hard ticks are the vectors for tbev, transmitting the virus to a variety of animals. the importance of these animals in the lifecycle of tbev is still up for debate. large woodland anim ... | 2019 | 31336624 |
| phylogeography of puumala orthohantavirus in europe. | puumala virus is an rna virus hosted by the bank vole (myodes glareolus) and is today present in most european countries. whilst it is generally accepted that hantaviruses have been tightly co-evolving with their hosts, puumala virus (puuv) evolutionary history is still controversial and so far has not been studied at the whole european level. this study attempts to reconstruct the phylogeographical spread of modern puuv throughout europe during the last postglacial period in the light of an upg ... | 2019 | 31344894 |
| gene-edited murine cell lines for propagation of chronic wasting disease prions. | prions cause fatal infectious neurodegenerative diseases in humans and animals. cell culture models are essential for studying the molecular biology of prion propagation. defining such culture models is mostly a random process, includes extensive subcloning, and for many prion diseases few or no models exist. one example is chronic wasting disease (cwd), a highly contagious prion disease of cervids. to extend the range of cell models propagating cwd prions, we gene-edited mouse cell lines known ... | 2019 | 31371793 |
| early life of fathers affects offspring fitness in a wild rodent. | intergenerational fitness effects on offspring due to the early life of the parent are well studied from the standpoint of the maternal environment, but intergenerational effects owing to the paternal early life environment are often overlooked. nonetheless, recent laboratory studies in mammals and ecologically relevant studies in invertebrates predict that paternal effects can have a major impact on the offspring's phenotype. these nongenetic, environment-dependent paternal effects provide a me ... | 2019 | 31390473 |
| genomic and spatial variability of a european common vole hepevirus. | rodents host different orthohepeviruses, namely orthohepevirus c genotype hev-c1 (rat hepatitis e virus, hev) and the additional putative genotypes hev-c3 and hev-c4. here, we screened 2,961 rodents from central europe by reverse transcription polymerase chain reaction (rt-pcr) and identified hev rna in 13 common voles (microtus arvalis) and one bank vole (myodes glareolus) with detection rates of 2% (95% confidence interval [ci]: 1-3.4) and 0.08% (95% ci: 0.002-0.46), respectively. sequencing o ... | 2019 | 31399875 |
| experimental evolution of personality traits: open-field exploration in bank voles from a multidirectional selection experiment. | evolution of complex physiological adaptations could be driven by natural selection acting on behavioral traits. consequently, animal personality traits and their correlation with physiological traits have become an engaging research area. here, we applied a unique experimental evolution model-lines of bank voles selected for (a) high exercise-induced aerobic metabolism, (h) ability to cope with low-quality herbivorous diet, and (p) intensity of predatory behavior, that is, traits shaping evolut ... | 2019 | 31413710 |
| the effect of monoamines reuptake inhibitors on aerobic exercise performance in bank voles from a selection experiment. | exercise performance depends on both physiological abilities (e.g., muscle strength) and behavioral characteristics (e.g., motivation). we tested the hypothesis that evolution of increased aerobic exercise performance can be facilitated by evolution of neuropsychological mechanisms responsible for motivation to undertake physical activity. we used a unique model system: lines of bank voles myodes glareolus selected for high swim-induced aerobic metabolism ("aerobic" a lines). in generation 21, v ... | 2019 | 31413714 |
| effect of estrogen-related receptor silencing on mirna protein machinery expression, global methylation, and deacetylation in bank vole (myodes glareolus) and mouse tumor leydig cells. | the function of estrogen-related receptor (err) in testicular cells is at the beginning of exploration. our previous findings showed that expression pattern of estrogen-related receptor (err) in mouse leydig cell depends on physiological status of the cell. exogenous hormones/hormonally active chemicals affect err expression. in leydig cells in vitro, errα and errγ show opposing regulatory properties. the aim of this study was to examine the role of err in epigenetic processes in cells with alte ... | 2019 | 31421412 |
| rodent mothers increase vigilance behaviour when facing infanticide risk. | infanticide, the killing of unrelated young, is widespread and frequently driven by sexual conflict. especially in mammals with exclusive maternal care, infanticide by males is common and females suffer fitness costs. recognizing infanticide risk and adjusting offspring protection accordingly should therefore be adaptive in female mammals. using a small mammal (myodes glareolus) in outdoor enclosures, we investigated whether lactating mothers adjust offspring protection, and potential mate searc ... | 2019 | 31427633 |
| first detection of tick-borne encephalitis virus in ixodes ricinus ticks and their rodent hosts in moscow, russia. | here, we report the first confirmed autochthonous tick-borne encephalitis case diagnosed in moscow in 2016 and describe the detection of tick-borne encephalitis virus (tbev) in ticks and small mammals in a moscow park. the paper includes data from two patients who were bitten by tbev-infected ticks in moscow city; one of these cases led to the development of the meningeal form of tbe. both tbev-infected ticks attacked patients in the same area. we collected ticks and trapped small mammals in thi ... | 2019 | 31447316 |
| impact of vertebrate communities on ixodes ricinus-borne disease risk in forest areas. | the density of questing ticks infected with tick-borne pathogens is an important parameter that determines tick-borne disease risk. an important factor determining this density is the availability of different wildlife species as hosts for ticks and their pathogens. here, we investigated how wildlife communities contribute to tick-borne disease risk. the density of ixodes ricinus nymphs infected with borrelia burgdorferi (sensu lato), borrelia miyamotoi, neoehrlichia mikurensis and anaplasma pha ... | 2019 | 31492171 |
| exposure to environmental radionuclides is associated with altered metabolic and immunity pathways in a wild rodent. | wildlife inhabiting environments contaminated by radionuclides face putative detrimental effects of exposure to ionizing radiation, with biomarkers such as an increase in dna damage and/or oxidative stress commonly associated with radiation exposure. to examine the effects of exposure to radiation on gene expression in wildlife, we conducted a de novo rna sequencing study of liver and spleen tissues from a rodent, the bank vole myodes glareolus. bank voles were collected from the chernobyl exclu ... | 2019 | 31498518 |
| common vole (microtus arvalis) and bank vole (myodes glareolus) derived permanent cell lines differ in their susceptibility and replication kinetics of animal and zoonotic viruses. | pathogenesis and reservoir host adaptation of animal and zoonotic viruses are poorly understood due to missing adequate cell culture and animal models. the bank vole (myodes glareolus) and common vole (microtus arvalis) serve as hosts for a variety of zoonotic pathogens. for a better understanding of virus association to a putative animal host, we generated two novel cell lines from bank voles of different evolutionary lineages and two common vole cell lines and assayed their susceptibility, rep ... | 2019 | 31513859 |
| maternal antibodies provide bank voles with strain-specific protection against infection by the lyme disease pathogen. | multistrain microbial pathogens often induce strain-specific antibody responses in their vertebrate hosts. mothers can transmit antibodies to their offspring, which can provide short-term, strain-specific protection against infection. few experimental studies have investigated this phenomenon for multiple strains of zoonotic pathogens occurring in wildlife reservoir hosts. the tick-borne bacterium borrelia afzelii causes lyme disease in europe and consists of multiple strains that cycle between ... | 2019 | 31540991 |
| characterization of the puumala orthohantavirus strains in the northwestern region of the republic of tatarstan in relation to the clinical manifestations in hemorrhagic fever with renal syndrome patients. | over 1,000 cases of hemorrhagic fever with renal syndrome (hfrs) were recorded in the republic of tatarstan (rt) in 2015. hfrs is a zoonotic disease caused by several different old world hantaviruses. in rt, puumala orthohantavirus (puuv) is a prevalent etiological agent of hfrs. we looked for the genetic link between the puuv strains isolated from the bank voles and from the infected humans. in addition, possible correlation between the genetic makeup of the puuv strain involved and different c ... | 2019 | 31543819 |
| stress coping and evolution of aerobic exercise performance: corticosterone levels in voles from a selection experiment. | the locomotor performance achieved in a challenging situation depends not only on physiological limitations, such as the aerobic exercise capacity, but also on behavioral characteristics, such as adequate coping with stress. the stress response is mediated largely by the hypothalamic-pituitary-adrenal (hpa) axis, through modulated release of glucocorticoids. we used a unique experimental evolution model system to test the hypothesis that the evolution of an increased aerobic exercise performance ... | 2019 | 31548286 |
| the prevalence of pathogenic forms of leptospira in natural populations of small wild mammals in serbia. | the greatest epidemiological significance of leptospirosis in europe comes from the fact that it is the most widespread zoonosis in the world. however, epizootiological data, especially information on maintenance hosts such as small wild mammals, are largely missing. to fill this gap in data in serbia, we used rt-pcr for the detection of pathogenic leptospira species and analysed 107 animals belonging to six species of small wild mammals (apodemus agrarius, apodemus flavicollis, microtus arvalis ... | 2019 | 31549550 |
| borrelia spp. in small mammals in romania. | small mammals play an important role in the life-cycle of ticks and are reservoirs for several zoonotic pathogens. the aim of this study was to provide epidemiological data regarding the presence of borrelia spp. in tissues of small mammals from romania. | 2019 | 31551069 |
| one-decade-spanning transgenerational effects of historic radiation dose in wild populations of bank voles exposed to radioactive contamination following the chernobyl nuclear disaster. | the concept of historic radiation doses associated with accidental radioactive releases and their role in leading to radiation-induced non-targeted effects on affected wild animals are currently being evaluated. previous research studying fukushima butterfly, chernobyl bird and fruit fly populations shows that the effects are transgenerational, underlined by the principles of genomic instability, and varied from one species to another. to further expand on the responses of and their sensitivity ... | 2020 | 31627157 |
| parasites in brains of wild rodents (arvicolinae and murinae) in the city of leipzig, germany. | small rodents serve as intermediate or paratenic hosts for a variety of parasites and may participate in the transmission of these parasites into synanthropic cycles. parasites with neuroinvasive stages, such as toxoplasma gondii or toxocara canis, can cause detrimental damage in the brain of intermediate or paratenic hosts. therefore, the occurrence of neuroinvasive parasite stages was evaluated in brains of wild rodents captured in the city of leipzig, germany. in addition, a few specimens fro ... | 2019 | 31667084 |
| small mammal responses to long-term large-scale woodland creation: the influence of local and landscape-level attributes. | habitat loss and fragmentation greatly affect biological diversity. actions to counteract their negative effects include increasing the quality, amount and connectivity of seminatural habitats at the landscape scale. however, much of the scientific evidence underpinning landscape restoration comes from studies of habitat loss and fragmentation, and it is unclear whether the ecological principles derived from habitat removal investigations are applicable to habitat creation. in addition, the rela ... | 2020 | 31670888 |
| heterogeneous puumala orthohantavirus situation in endemic regions in germany in summer 2019. | puumala orthohantavirus (puuv) causes most human hantavirus disease cases in europe. puuv disease outbreaks are usually synchronized germany-wide driven by beech mast-induced irruptions of its host (bank vole, myodes glareolus). recent data indicate high vole abundance, high puuv prevalence and high human incidence in summer 2019 for some regions, but elsewhere values were low to moderate. this significant lack of synchrony among regions in germany is in contrast to previous studies. health inst ... | 2020 | 31674714 |
| levels, patterns, and biomagnification potential of perfluoroalkyl substances in a terrestrial food chain in a nordic skiing area. | perfluoroalkyl substances (pfass) are used in a wide range of consumer products, including ski products, such as ski waxes. however, there is limited knowledge on the release of pfass from such products into the environment and the resultant uptake in biota and transport in food webs. we investigated levels, patterns, and biomagnification of pfass in soil, earthworms (eisenia fetida), and bank voles (myodes glareolus) from a skiing area in trondheim, norway. in general, there was higher pfas lev ... | 2019 | 31691564 |
| retraction: in vitro studies of interactions between frequent and unique mrnas and cytoplasmic factors from brain tissue of several species of wild timber voles of northern eurasia, clethrionomys glareolus, clethrionomys frater and clethrionomys gapperi: a new criticism to a modern molecular-genetic concept of biological evolution. | 2020 | 31701785 | |
| in vivo characterization of tick-borne encephalitis virus in bank voles (myodes glareolus). | tick-borne encephalitis is the most important tick-transmitted zoonotic virus infection in eurasia, causing severe neurological symptoms in humans. the causative agent, the tick-borne encephalitis virus (tbev), circulates between ticks and a variety of mammalian hosts. to study the interaction between tbev and one of its suspected reservoir hosts, bank voles of the western evolutionary lineage were inoculated subcutaneously with either one of eight tbev strains or the related attenuated langat v ... | 2019 | 31731773 |
| concentration of mercury in the livers of small terrestrial rodents from rural areas in poland. | small terrestrial mammals could be used as accumulative biomonitors of different environmental contaminants, but the knowledge of the level of hg in their bodies is scant. the aim of our research was to verify the factors influencing hg bioaccumulation and to analyze the concentration of total mercury (hg) in the livers of four species of wild terrestrial rodents from different rural areas of poland: the yellow-necked mouse (apodemus flavicollis), striped field mouse (apodemus agrarius), common ... | 2019 | 31739423 |
| molecular detection and characterization of the first cowpox virus isolate derived from a bank vole. | cowpox virus (cpxv) is a zoonotic orthopoxvirus (opv) that infects a wide range of mammals. cpxv-specific dna and antibodies were detected in different vole species, such as common voles (microtus arvalis) and bank voles (myodes glareolus). therefore, voles are the putative main reservoir host of cpxv. however, cpxv was up to now only isolated from common voles. here we report the detection and isolation of a bank vole-derived cpxv strain (germygek 938/17) resulting from a large-scale screening ... | 2019 | 31752129 |
| parasite load and site-specific parasite pressure as determinants of immune indices in two sympatric rodent species. | wildlife is exposed to parasites from the environment. this parasite pressure, which differs among areas, likely shapes the immunological strategies of animals. individuals differ in the number of parasites they encounter and host, and this parasite load also influences the immune system. the relative impact of parasite pressure vs. parasite load on different host species, particularly those implicated as important reservoirs of zoonotic pathogens, is poorly understood. we captured bank voles (m ... | 2019 | 31766647 |
| wildfire-induced short-term changes in a small mammal community increase prevalence of a zoonotic pathogen? | natural disturbances like droughts and fires are important determinants of wildlife community structure and are suggested to have important implications for prevalence of wildlife-borne pathogens. after a major wildfire affecting >1,600 ha of boreal forest in sweden in 2006, we took the rare opportunity to study the short-term response (2007-2010 and 2015) of small mammal community structure, population dynamics, and prevalence of the puumala orthohantavirus (puuv) hosted by bank voles (myodes g ... | 2019 | 31788190 |
| use of different rt-quic substrates for detecting cwd prions in the brain of norwegian cervids. | chronic wasting disease (cwd) is a highly contagious prion disease affecting captive and free-ranging cervid populations. cwd has been detected in united states, canada, south korea and, most recently, in europe (norway, finland and sweden). animals with cwd release infectious prions in the environment through saliva, urine and feces sustaining disease spreading between cervids but also potentially to other non-cervids ruminants (e.g. sheep, goats and cattle). in the light of these consideration ... | 2019 | 31819115 |
| temporal dynamics of two pathogenic hantaviruses among rodents in hungary. | hantaviruses are worldwide pathogens, which often cause serious or even fatal diseases in humans. hosts are predominantly in the form of rodents and soricomorphs; however, bats are also described as an important reservoir. in hungary, representatives of two human pathogenic species of the genus orthohantavirus are present: the dobrava-belgrade orthohantavirus and puumala orthohantavirus. in hungarian forests, the dominant rodent species are apodemus flavicollis, apodemus agrarius, apodemus sylva ... | 2020 | 31821117 |
| quaking-induced conversion of prion protein on a thermal mixer accelerates detection in brains infected with transmissible spongiform encephalopathy agents. | detection of misfolded prion protein, prptse, in biological samples is important to develop antemortem tests for transmissible spongiform encephalopathies (tses). the real-time quaking-induced conversion (rt-quic) assay detects prptse but requires dedicated equipment and relatively long incubation times when applied to samples containing extremely low levels of prptse. it was shown that a microplate shaker with heated top (thermomixer-c) accelerated amplification of prptse in brain suspensions o ... | 2019 | 31830760 |
| coxiella burnetii and francisella tularensis in wild small mammals from the czech republic. | wild rodents are an important source of the tick-borne pathogens coxiella burnetii and francisella tularensis. the aim of our study was to assess the prevalence of antibodies and possible coexistence of these pathogens in wild small mammals from three localities in the czech republic. a total of 614 wild small mammals (324 apodemus flavicollis, 145 myodes glareolus, 50 sorex araneus, 48 a. sylvaticus, 40 a. agrarius, six microtus arvalis and one talpa europaea) were trapped between 2012 and 2015 ... | 2020 | 31848075 |
| blood parasites (babesia, hepatozoon and trypanosoma) of rodents, lithuania: part i. molecular and traditional microscopy approach. | wild rodents, as natural reservoir hosts carrying various species of pathogens, play an important role in the evolution and emergence of zoonotic diseases. in this study, protist parasites, namely babesia sp., trypanosoma sp. and hepatozoon sp. were studied in rodent populations in lithuania. two hundred forty rodent specimens of seven species were analysed by a combined approach using polymerase chain reaction (pcr)-based techniques and traditional microscopic examination. the total prevalence ... | 2020 | 31897793 |
| infection load and prevalence of novel viruses identified from the bank vole do not associate with exposure to environmental radioactivity. | bank voles (myodes glareolus) are host to many zoonotic viruses. as bank voles inhabiting areas contaminated by radionuclides show signs of immunosuppression, resistance to apoptosis, and elevated dna repair activity, we predicted an association between virome composition and exposure to radionuclides. to test this hypothesis, we studied the bank vole virome in samples of plasma derived from animals inhabiting areas of ukraine (contaminated areas surrounding the former nuclear power plant at che ... | 2019 | 31905955 |
| role of donor genotype in rt-quic seeding activity of chronic wasting disease prions using human and bank vole substrates. | chronic wasting disease is a transmissible spongiform encephalopathy of cervids. this fatal neurodegenerative disease is caused by misfolding of the cellular prion protein (prpc) to pathogenic conformers (prpsc), and the pathogenic forms accumulate in the brain and other tissues. real-time quaking induced conversion (rt-quic) can be used for the detection of prions and for prion strain discrimination in a variety of biological tissues from humans and animals. in this study, we evaluated how eith ... | 2020 | 31910440 |
| cocirculation of two orthohantavirus species in small mammals of the northwestern ukraine. | rodent-borne hantaviruses have been reported in many of the countries surrounding ukraine; however, to date we have no knowledge of the viral strains circulating in ukraine within reservoirs such as the striped field mouse (apodemus agrarius), the yellow-necked field mouse (apodemus flavicollis), and the bank vole (myodes glareolus). to determine the prevalence of hantaviruses in ukraine, we captured 1,261 mammals, of which 1,109 were rodents, in 58 field sites within the province of volyn in we ... | 2020 | 31917639 |
| my niche: individual spatial niche specialization affects within- and between-species interactions. | intraspecific trait variation is an important determinant of fundamental ecological interactions. many of these interactions are mediated by behaviour. therefore, interindividual differences in behaviour should contribute to individual niche specialization. comparable with variation in morphological traits, behavioural differentiation between individuals should limit similarity among competitors and thus act as a mechanism maintaining within-species variation in ecological niches and facilitatin ... | 2020 | 31937229 |
| deciphering copper coordination in the mammalian prion protein amyloidogenic domain. | prions are pathological isoforms of the cellular prion protein that is responsible for transmissible spongiform encephalopathies (tse). cellular prion protein interacts with copper, cu(ii), through octarepeat and nonoctarepeat (non-or) binding sites. the molecular details of cu(ii) coordination within the non-or region are not well characterized yet. by the means of small angle x-ray scattering and x-ray absorption spectroscopic methods, we have investigated the effect of cu(ii) on prion protein ... | 2020 | 31952810 |
| spatio-temporal variation of metals and organic contaminants in bank voles (myodes glareolus). | environmental contamination with metals and organic compounds is of increasing concern for ecosystem and human health. still, our knowledge about spatial distribution, temporal changes and ecotoxicological fate of metals and organic contaminants in wildlife is limited. we studied concentrations of 69 elements and 50 organic compounds in 300 bank voles (myodes glareolus), europe's most common mammal, sampled in spring and autumn 2017-2018 in five monitoring areas, representing three biogeographic ... | 2020 | 31955071 |
| the hidden faces of a biological invasion: parasite dynamics of invaders and natives. | one of the primary drivers of emerging infectious diseases (eids) is human intervention via host or parasite translocations. a unique opportunity to study host and parasite dispersal during a bio-invasion currently exists in ireland due to the introduction of the bank vole (myodes glareolus) in the 1920s. the continuing range expansion of m. glareolus within ireland presents a natural large-scale perturbation experiment. this study used the irish m. glareolus model to conduct a spatiotemporal st ... | 2020 | 31981672 |
| patchy occurrence of cowpox virus in voles from germany. | cowpox virus (cpxv), genus orthopoxvirus, family poxviridae, is a zoonotic pathogen in eurasian wild rodents. high seroprevalences have been reported previously for vole and murine species in europe. in contrast, viral dna was only rarely detected, and very few reservoir-derived cpxv isolates exist. in this study, cpxv dna and cpxv-reactive antibodies were monitored in wild small mammals for 5 years in four german federal states. screening of liver tissues of 3966 animals by cpxv real-time pcr ( ... | 2020 | 32013767 |
| ticks on the channel islands and implications for public health. | the channel islands are british crown dependencies located in the english channel to the west of the normandy coast in northern france. whilst there have been studies investigating tick occurrence and distribution in different habitats on the mainland of the uk and in france, the channel islands have been relatively understudied. as such, little is known about whether the sheep tick, ixodes ricinus, is present, and whether there is a potential risk of lyme borreliosis on the channel islands. to ... | 2020 | 32046929 |
| generalist eimeria species in rodents: multilocus analyses indicate inadequate resolution of established markers. | intracellular parasites of the genus eimeria are described as tissue/host-specific. phylogenetic classification of rodent eimeria suggested that some species have a broader host range than previously assumed. we explore whether eimeria spp. infecting house mice are misclassified by the most widely used molecular markers due to a lack of resolution, or whether, instead, these parasite species are indeed infecting multiple host species.with the commonly used markers (18s/coi), we recovered monophy ... | 2020 | 32076521 |
| rodents as intermediate hosts of cestode parasites of mammalian carnivores and birds of prey in poland, with the first data on the life-cycle of mesocestoides melesi. | rodents constitute an important part of the diet of many carnivore species. this predator-prey food chain is exploited by helminth parasites, such as cestodes, whose larval stages develop in rodents and then mature to the adult stage in predators. the main aim of our study was to use molecular techniques for identification of cestode species recovered from both intermediate and definitive hosts, with a particular focus on the genus mesocestoides. | 2020 | 32087754 |
| in vivo characterization of a bank vole-derived cowpox virus isolate in natural hosts and the rat model. | cowpox virus (cpxv) belongs to the genus orthopoxvirus in the poxviridae family and is endemic in western eurasia. based on seroprevalence studies in different voles from continental europe and uk, voles are suspected to be the major reservoir host. recently, a cpxv was isolated from a bank vole (myodes glareolus) in germany that showed a high genetic similarity to another isolate originating from a cotton-top tamarin (saguinus oedipus). here we characterize this first bank vole-derived cpxv iso ... | 2020 | 32093366 |
| combining genome-wide association study and fst -based approaches to identify targets of borrelia-mediated selection in natural rodent hosts. | recent advances in high-throughput sequencing technologies provide opportunities to gain novel insights into the genetic basis of phenotypic trait variation. yet to date, progress in our understanding of genotype-phenotype associations in nonmodel organisms in general and natural vertebrate populations in particular has been hampered by small sample sizes typically available for wildlife populations and a resulting lack of statistical power, as well as a limited ability to control for false-posi ... | 2020 | 32163646 |
| high genomic diversity in the bank vole at the northern apex of a range expansion: the role of multiple colonizations and end-glacial refugia. | the history of repeated northern glacial cycling and southern climatic stability has long dominated explanations for how genetic diversity is distributed within temperate species in eurasia and north america. however, growing evidence indicates the importance of cryptic refugia for northern colonization dynamics. an important geographic region to assess this is fennoscandia, where recolonization at the end of the last glaciation was restricted to specific routes and temporal windows. we used gen ... | 2020 | 32248595 |
| cofactor and glycosylation preferences for in vitro prion conversion are predominantly determined by strain conformation. | prion diseases are caused by the misfolding of a host-encoded glycoprotein, prpc, into a pathogenic conformer, prpsc. infectious prions can exist as different strains, composed of unique conformations of prpsc that generate strain-specific biological traits, including distinctive patterns of prpsc accumulation throughout the brain. prion strains from different animal species display different cofactor and prpc glycoform preferences to propagate efficiently in vitro, but it is unknown whether the ... | 2020 | 32294141 |
| isolation of infectious, non-fibrillar and oligomeric prions from a genetic prion disease. | prions are transmissible agents causing lethal neurodegenerative diseases that are composed of aggregates of misfolded cellular prion protein (prpsc). despite non-fibrillar oligomers having been proposed as the most infectious prion particles, prions purified from diseased brains usually consist of large and fibrillar prpsc aggregates, whose protease-resistant core (prpres) encompasses the whole c-terminus of prp. in contrast, prpsc from gerstmann-sträussler-scheinker disease associated with ala ... | 2020 | 32303068 |
| associations between different laelapidae (mesostigmata: dermanyssoidea) mites and small rodents from lithuania. | associations between species of laelapidae (mesostigmata: dermanyssoidea) mites and small rodents have been studied insufficiently. the aim of this study was to investigate infestation patterns of small rodent species by laelapid mites at six locations in lithuania. a total of 728 rodents were snap- and live-trapped in various locations during 2013-2016. eight rodent species were identified, namely apodemus flavicollis, apodemus agrarius, myodes glareolus, micromys minutus, mus musculus, microtu ... | 2020 | 32307619 |
| molecular epidemiology and genetic diversity of orthohantaviruses in small mammals in western poland. | orthohantaviruses are negative-sense, single-stranded rna viruses harbored by multiple small mammals. dobrava-belgrade virus (dobv) and puumala virus (puuv) cause hemorrhagic fever with renal syndrome (hfrs) in europe. in poland, serological surveys have demonstrated antibodies against dobv and puuv in patients with hfrs. molecular evidence of dobv and puuv has been found in apodemus flavicollis and myodes glareolus, respectively, in southeastern poland, and seewis virus (swsv) has been reported ... | 2020 | 32314690 |
| orthohantavirus isolated in reservoir host cells displays minimal genetic changes and retains wild-type infection properties. | : orthohantaviruses are globally emerging zoonotic pathogens. while the reservoir host role of several rodent species is well-established, detailed research on the mechanisms of host-othohantavirus interactions has been constrained by the lack of an experimental system that is able to effectively replicate natural infections in controlled settings. here we report the isolation, and genetic and phenotypic characterization of a novel puumala orthohantavirus (puuv) in cells derived from its reservo ... | 2020 | 32316667 |
| isolation and characterization of new puumala orthohantavirus strains from germany. | orthohantaviruses are re-emerging rodent-borne pathogens distributed all over the world. here, we report the isolation of a puumala orthohantavirus (puuv) strain from bank voles caught in a highly endemic region around the city osnabrück, north-west germany. coding and non-coding sequences of all three segments (s, m, and l) were determined from original lung tissue, after isolation and after additional passaging in veroe6 cells and a bank vole-derived kidney cell line. different single amino ac ... | 2020 | 32328924 |
| selective predation by owls on infected bank voles (myodes glareolus) as a possible sentinel of tularemia outbreaks. | tularemia is a widely spread zoonotic disease in the northern hemisphere, caused by the bacterium francisella tularensis. in humans, tularemia is an acute febrile illness with incidence peaks in late summer to early autumn of outbreak years, but there is no early warning system in place that can reduce the impact of disease by providing timely risk information. in this study, we revisit previously unpublished data on f. tularensis in water, sediment, soil, and small mammals from 1984 in northern ... | 2020 | 32349636 |
| detection of rickettsia spp. in fleas collected from small mammals in slovakia, central europe. | this survey is aimed at investigation of species composition of fleas removed from small terrestrial mammals captured in rural, suburban, and urban types of habitat and molecular screening of the presence and diversity of rickettsia species in collected ectoparasites. in total, 279 fleas (siphonaptera) belonging to 9 species of 2 families, ceratophyllidae and hystrichopsyllidae, were collected from 115 (46%) out of 250 trapped small mammals of eight species (apodemus agrarius, apodemus flavicoll ... | 2020 | 32366189 |
| balancing selection in pattern recognition receptor signalling pathways is associated with gene function and pleiotropy in a wild rodent. | pathogen-mediated balancing selection is commonly considered to play an important role in the maintenance of genetic diversity, in particular in immune genes. however, the factors that may influence which immune genes are the targets of such selection are largely unknown. to address this, here we focus on pattern recognition receptor (prr) signalling pathways, which play a key role in innate immunity. we used whole-genome resequencing data from a population of bank voles (myodes glareolus) to te ... | 2020 | 32374503 |
| circulation of rickettsia species and rickettsial endosymbionts among small mammals and their ectoparasites in eastern slovakia. | bacteria belonging to the genus rickettsia are known as causative agents of vector-borne zoonotic diseases, such as spotted fevers, epidemic typhus and endemic typhus. different species of ticks, mites and fleas could act as reservoirs and arthropod vectors of different pathogenic rickettsia species. the aim of this work was to establish active surveillance of rickettsia spp. in mites, ticks and fleas collected from small mammals (rodents and shrews) in eastern slovakia. a total of 964 animal ea ... | 2020 | 32382991 |
| on the doorstep, rodents in homesteads and kitchen gardens. | scarcely investigated in terms of small mammals, kitchen gardens and homesteads form a subset of environments. using results of snap trapping, we present the first data on small mammal species diversity, gender and age structure, relative abundance, body fitness, and reproduction parameters in these commensal habitats (kitchen gardens, homestead gardens, houses, and outbuildings). we expected that (i) house mice should be the dominant species in buildings, while striped field mice should be domi ... | 2020 | 32429138 |
| distribution of ticks, tick-borne pathogens and the associated local environmental factors including small mammals and livestock, in two french agricultural sites: the oscar database. | in europe, ticks are major vectors of both human and livestock pathogens (e.g. lyme disease, granulocytic anaplasmosis, bovine babesiosis). agricultural landscapes, where animal breeding is a major activity, constitute a mosaic of habitat types of various quality for tick survival and are used at different frequencies by wild and domestic hosts across seasons. this habitat heterogeneity, in time and space, conditions the dynamics of these host-vector-pathogen systems and thus drives acarological ... | 2020 | 32431559 |
| geographical distribution of ljungan virus in small mammals in europe. | ljungan virus (lv), which belongs to the parechovirus genus in the picornaviridae family, was first isolated from bank voles (myodes glareolus) in sweden in 1998 and proposed as a zoonotic agent. to improve knowledge of the host association and geographical distribution of lv, tissues from 1685 animals belonging to multiple rodent and insectivore species from 12 european countries were screened for lv-rna using reverse transcriptase (rt)-pcr. in addition, we investigated how the prevalence of lv ... | 2020 | 32487013 |
| does selection for behavioral and physiological performance traits alter glucocorticoid responsiveness in bank voles? | one of the key elements of an animal's darwinian fitness is its ability to adequately respond to and cope with challenging situations. glucocorticoid hormones, such as corticosterone, affect an organism's ability to overcome such challenges. we hypothesized that changes in the glucocorticoid response curve contribute to the evolution of increased performance during challenging conditions, and tested it on bank voles (myodes glareolus) from a multidirectional artificial selection experiment, whic ... | 2020 | 32561625 |
| relationship between heavy metal accumulation and histological alterations in voles from alpine and forest habitats of the west carpathians. | the interaction between toxic heavy metals and bio-elements in internal organs and femoral bones and their potential impacts on bone structural properties and renal histopathological changes in bank voles and snow voles were investigated. our results reveal that heavy metals hg and pb accumulate more in femoral bones of alpine habitats than forests. in snow voles, the parameters of the primary osteons' vascular canals (length, average perimeter and area) simultaneously decreased with an increase ... | 2020 | 32562226 |
| tick-borne encephalitis virus: seasonal and annual variation of epidemiological parameters related to nymph-to-larva transmission and exposure of small mammals. | a greater knowledge of the ecology of the natural foci of tick-borne encephalitis virus (tbev) is essential to better assess the temporal variations of the risk of tick-borne encephalitis for humans. to describe the seasonal and inter-annual variations of the tbev-cycle and the epidemiological parameters related to tbev nymph-to-larva transmission, exposure of small mammals to tbev, and tick aggregation on small mammals, a longitudinal survey in ticks and small mammals was conducted over a 3-yea ... | 2020 | 32605114 |
| the metabolic performance predicts home range size of bank voles: a support for the behavioral-bioenergetics theory. | the pace-of-life syndrome describes covariation between life-history, behavioral and physiological traits; while, the emerging behavioral-bioenergetics theory proposes mechanistic links between those traits in a spatial-ecological context. however, little is known about the association between the limits to metabolic rate and spatial performance (i.e., mobility, home range size) in free-living individuals. here we show, for the first time at the intra-specific level, that mobility traits increas ... | 2020 | 32638120 |
| prevalence of the puumala orthohantavirus strains in the pre-kama area of the republic of tatarstan, russia. | puumala orthohantavirus (puuv) causes nephropathia epidemica (ne), a mild form of hemorrhagic fever with renal syndrome (hfrs) commonly diagnosed in europe. the majority of hfrs cases in the european part of russia are diagnosed in the volga federal district, which includes the republic of tatarstan (rt). the current study aims to analyze the genetic variability of puuv in pre-kama region of the rt bounded by the volga, kama, and vyatka rivers. in 2017, bank voles were caught in seven isolated f ... | 2020 | 32640614 |
| spatial and temporal evolutionary patterns in puumala orthohantavirus (puuv) s segment. | the s segment of bank vole (clethrionomys glareolus)-associated puumala orthohantavirus (puuv) contains two overlapping open reading frames coding for the nucleocapsid (n) and a non-structural (nss) protein. to identify the influence of bank vole population dynamics on puuv s segment sequence evolution and test for spillover infections in sympatric rodent species, during 2010-2014, 883 bank voles, 357 yellow-necked mice (apodemus flavicollis), 62 wood mice (a. sylvaticus), 149 common voles (micr ... | 2020 | 32650456 |
| the effect of chronic low-dose environmental radiation on organ mass of bank voles in the chernobyl exclusion zone. | animals are exposed to environmental ionizing radiation (ir) externally through proximity to contaminated soil and internally through ingestion and inhalation of radionuclides. internal organs can respond to radioactive contamination through physiological stress. chronic stress can compromise the size of physiologically active organs, but studies on wild mammal populations are scarce. the effects of environmental ir contamination on organ masses were studied by using a wild rodent inhabiting the ... | 2020 | 32658635 |
| ticks, fleas and rodent-hosts analyzed for the presence of borrelia miyamotoi in slovakia: the first record of borrelia miyamotoi in a haemaphysalis inermis tick. | in slovakia, little knowledge is available on the occurrence, hosts and vectors of borrelia miyamotoi of the relapsing fever group. in the current study, 2160 questing and rodent-attached ticks of six species (ixodes ricinus, ixodes trianguliceps, dermacentor marginatus, dermacentor reticulatus, haemaphysalis concinna and haemaphysalis inermis), 279 fleas belonging to 9 species (ctenophthalmus agyrtes, ctenophthalmus solutus, ctenophthalmus assimilis, megabothris turbidus, amalareus penicilliger ... | 2020 | 32723657 |
| comparison of spleen transcriptomes of two wild rodent species reveals differences in the immune response against borrelia afzelii. | different host species often differ considerably in susceptibility to a given pathogen, but the causes of such differences are rarely known. the natural hosts of the tick-transmitted bacterium borrelia afzelii, which is one of causative agents of lyme borreliosis in humans, include a variety of small mammals like voles and mice. previous studies have shown that b. afzelii-infected bank voles (myodes glareolus) have about ten times higher bacterial load than infected yellow-necked mice (apodemus ... | 2020 | 32724523 |
| effectiveness of antivirals in a type 1 diabetes model and the move toward human trials. | a picornavirus (ljungan virus [lv]) originally found in bank voles has been associated with type 1 diabetes (t1d) in its wild rodent reservoir, but also associated with t1d in a laboratory rat model for the disease, the diabetes prone (dp) bio breeding (bb) rat. successful treatment of diabetes in this rat model, using experimental antiviral compounds directed against picornavirus, has been reported. in the present study we show significant clinical response in dp-bb rats using antiviral compoun ... | 2020 | 32758075 |
| lack of evidence on the susceptibility of ticks and wild rodent species to pcv3 infection. | porcine circovirus 3 (pcv3) is an emerging virus, first detected in 2016 and widespread in the swine industry. although not considered a primary pathogen, pcv3 is potentially linked to several clinical conditions that threaten swine farming. wild boars are considered the main reservoir species for pcv3 infection in the wild, but recent detection in roe deer, chamois and associated ticks has complicated our understanding of its epidemiology. much emphasis has been placed on ticks, as competent ve ... | 2020 | 32825701 |
| detection and genetic characterization of puumala orthohantavirus s-segment in areas of france non-endemic for nephropathia epidemica. | puumala virus (puuv) in europe causes nephropathia epidemica (ne), a mild form of hemorrhagic fever with renal syndrome (hfrs). the incidence of ne is highly heterogeneous spatially, whereas the geographic distribution of the wild reservoir of puuv, the bank vole, is essentially homogeneous. our understanding of the processes driving this heterogeneity remains incomplete due to gaps in knowledge. little is known about the current distribution and genetic variation of puuv in the areas outside th ... | 2020 | 32882953 |
| intraspecific variation of body size in fleas: effects of host sex and flea phenology. | we investigated the effects of host sex and flea phenology (estimated as periods of high versus low abundance) on individual body size in four fleas of small mammals. amalaraeus penicilliger and ctenophthalmus uncinatus are ectoparasites of the bank vole myodes glareolus, whereas doratopsylla dasycnema and palaeopsylla soricis are ectoparasites of the common shrew sorex araneus. we found significant effects of host sex and phenology on the body size of all flea species, although there was no gen ... | 2020 | 32888066 |
| identification of a homology-independent linchpin domain controlling mouse and bank vole prion protein conversion. | prions are unorthodox pathogens that cause fatal neurodegenerative diseases in humans and other mammals. prion propagation occurs through the self-templating of the pathogenic conformer prpsc, onto the cell-expressed conformer, prpc. here we study the conversion of prpc to prpsc using a recombinant mouse prpsc conformer (mouse protein-only recprpsc) as a unique tool that can convert bank vole but not mouse prpc substrates in vitro. thus, its templating ability is not dependent on sequence homolo ... | 2020 | 32898162 |
| extending the enterovirus lead: could a related picornavirus be responsible for diabetes in humans? | we found an association between the abundance of rodents in the wild and onset of type 1 diabetes (t1d) in humans. a picornavirus named ljungan virus (lv) was subsequently isolated from wild bank voles. both picornavirus-like particles detected by electron microscopy and lv antigen visualized by immunohistochemistry was seen in islets of langerhans in diabetic wild bank voles. lv antigen has also been found in islets of langerhans in a patient with recent onset of t1d and in the commonly used bi ... | 2020 | 32927606 |
| applying the anna karenina principle for wild animal gut microbiota: temporal stability of the bank vole gut microbiota in a disturbed environment. | gut microbiota play an important role in host health. yet, the drivers and patterns of microbiota imbalance (dysbiosis) in wild animals remain largely unexplored. one hypothesised outcome of stress on animal microbiomes is a destabilised microbial community that is characterised by an increase in inter-individual differences compared with microbiomes of healthy animals, which are expected to be (a) temporally stable and (b) relatively similar among individuals. this set of predictions for respon ... | 2020 | 32939769 |
| do bank voles (myodes glareolus) trapped in live and lethal traps show differences in tick burden? | in studies assessing tick abundance, the use of live traps to capture and euthanize rodent hosts is a commonly used method to determine their burden. however, captive animals can experience debilitating or fatal capture stress as a result prior to collection. an alternative method is the use of lethal traps, but this can potentially lead to tick drop-off between the time of capture and collection. in this study, in order to determine whether subjecting animals to capture stress is inevitable, we ... | 2020 | 32941509 |
| molecular detection of bartonella spp. in rodents in chernobyl exclusion zone, ukraine. | bacteria of the genus bartonella are obligate parasites of vertebrates. their distribution range covers almost the entire world, from the americas to europe and asia. many bartonella species use rodents as reservoirs, and while much is known about bartonella infection of rodents in central europe, its extent is poorly understood in eastern europe. | 2020 | 32948932 |
| two distinct prions in fatal familial insomnia and its sporadic form. | fatal familial insomnia is a genetic prion disease, which is associated with the aspartic acid to asparagine substitution at codon 178 of the prion protein gene. although the hallmark pathological feature is thalamic and olivary degeneration, there is a patient with an atypical fatal familial insomnia without the hallmark feature. the cause of the pathological variability is unclear. we analysed a japanese fatal familial insomnia kindred and compared one atypical clinicopathological fatal famili ... | 2019 | 32954274 |
| the utility of bank voles for studying prion disease. | the transmission of prions between species is typically an inefficient process due to the species barrier, which represents incompatibility between prion seed and substrate molecules. bank voles (myodes glareolus) are an exception to this rule, as they are susceptible to a diverse range of prion strains from many different animal species. in particular, bank voles can be efficiently infected with most types of human prions and have played a critical role in validating variably protease-sensitive ... | 2020 | 32958232 |
| implication of membrane androgen receptor (zip9) in cell senescence in regressed testes of the bank vole. | here, we studied the impact of exposure to short daylight conditions on the expression of senescence marker (p16), membrane androgen receptor (zip9) and extracellular signal-regulated kinase (erk 1/2), as well as cyclic amp (camp) and testosterone levels in the testes of mature bank voles. animals were assigned to groups based on an analysis of testis diameter, weight, seminiferous tubule diameter and the interstitial tissue area: group 1, not fully regressed (the highest parameters); group 2 (m ... | 2020 | 32961828 |