Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| curcumin dually inhibits both mammalian target of rapamycin and nuclear factor-κb pathways through a crossed phosphatidylinositol 3-kinase/akt/iκb kinase complex signaling axis in adenoid cystic carcinoma. | adenoid cystic carcinoma (acc) is a highly malignant tumor that is generally unresponsive or only weakly responsive to the currently available antineoplastic agents. thus, novel therapeutic strategies and agents are urgently needed to treat this aggressive neoplasm. curcumin, a component of turmeric (curcuma longa), has been shown to have a diversity of antitumor activities. we show here that curcumin is a potent inhibitor of acc progression in vitro and in vivo. curcumin concentration-dependent ... | 2010 | 20959361 |
| curcuminoids rescue long-term potentiation impaired by amyloid peptide in rat hippocampal slices. | curcuminoids are vital constituent of turmeric, with therapeutic potential in the treatment of alzheimer's disease. electrically, stimulus train-elicited plastic changes in hippocampal ca1 excitability were used as an experimental paradigm to study the effects of curcuminoid mixture and individual components on functional failure induced by aβ peptide in vitro. electrical stimulation was applied on schaffer collaterals, and population spikes (ps) were recorded from stratum pyramidale. to induce ... | 2010 | 20963814 |
| [effect of nf-kappab activation inhibitor curcumin on the oogenesis and follicular cell death in immune ovarian failure in mice]. | in experiments on cba mice, we studied the influence of an inhibitor of nuclear transcription factor kappab activation curcumin, obtained from curcuma longa, on the meiotic maturation of oocytes and apoptotic and necrotic death of follicular cells at immune ovary failure induced by immunization of animals with allogenic ovarian extracts. nf-kappab plays a pivotal role in the induction of genes encoding pro-inflammatory factors (cytokines, adhesion molecules, inducible no-synthase and cyclooxygen ... | 2010 | 20968042 |
| biological reactive intermediates (bris) formed from botanical dietary supplements. | the use of botanical dietary supplements is increasingly popular, due to their natural origin and the perceived assumption that they are safer than prescription drugs. while most botanical dietary supplements can be considered safe, a few contain compounds, which can be converted to biological reactive intermediates (bris) causing toxicity. for example, sassafras oil contains safrole, which can be converted to a reactive carbocation forming genotoxic dna adducts. alternatively, some botanical di ... | 2011 | 20970412 |
| curcumin prevents leptin raising glucose levels in hepatic stellate cells by blocking translocation of glucose transporter-4 and increasing glucokinase. | hyperleptinemia is commonly found in obese patients, associated with non-alcoholic steatohepatitis and hepatic fibrosis. hepatic stellate cells (hscs) are the most relevant effectors during hepatic fibrogenesis. we recently reported that leptin stimulated hsc activation, which was eliminated by curcumin, a phytochemical from turmeric. this study was designed to explore the underlying mechanisms, focusing on their effects on intracellular glucose in hscs. we hypothesized that leptin stimulated hs ... | 2010 | 20977462 |
| turmeric and vegetable oils as repellents against anopheline mosquitoes. | 1945 | 21007256 | |
| free radical scavenging activity and characterization of sesquiterpenoids in four species of curcuma using a tlc bioautography assay and gc-ms analysis. | the sesquiterpenoids are one of major groups of antioxidants in curcuma besides curcuminoids. however, the real substances contributing to the antioxidant activity are still unknown. in this paper, the antioxidant activity of sesquiterpenoids in four species and two essential oils from curcuma genus was determined and compared based on tlc separation and dpph bioautography assay. their antioxidant capacities were quantitatively evaluated using densitometry with detection at 530 nm (λ(reference ) ... | 2010 | 21030908 |
| preparation and characterization of water-soluble albumin-bound curcumin nanoparticles with improved antitumor activity. | curcumin (ccm), a yellow natural polyphenol extracted from turmeric (curcuma longa), has potent anti-cancer properties as has been demonstrated in various human cancer cells. however, the widespread clinical application of this efficient agent in cancer and other diseases has been limited by its poor aqueous solubility and bioavailability. in this study, we prepared novel ccm-loaded human serum albumin (hsa) nanoparticles (ccm-hsa-nps) for intravenous administration using albumin bound technolog ... | 2010 | 21035530 |
| effects of curcumin (diferuloylmethane) on eimeria tenella sporozoites in vitro. | the negative effects of coccidiosis on poultry health and productivity and increasing problems related to drug resistance have stimulated the search for novel and alternative methods of control. the present study evaluates the anticoccidial activity of curcumin (diferuloylmethane), a natural polyphenolic compound abundant in the rhizome of the perennial herb turmeric (curcuma longa) which is a spice and food colorant commonly used in curries and also used as medicinal herb. its effects were eval ... | 2010 | 21057813 |
| protective effects of curcuma longa against cerulein-induced acute pancreatitis and pancreatitis-associated lung injury. | curcuma longa (cl) has been reported to possess a variety of pharmacological activities. however, the effects of cl on acute pancreatitis (ap) have not yet been determined. to this end, we examined the effects of cl on cerulein-induced ap. cell viability and cytokine productions were measured in pancreatic acini. mice were divided into 3 groups: i) normal group, ii) normal saline-treated group, iii) group treated with cl at a dose of 0.05, 0.1, 0.5 and 1 g/kg. cl was administered orally to mice ... | 2010 | 21069254 |
| curcumin induces maturation-arrested dendritic cells that expand regulatory t cells in vitro and in vivo. | dendritic cells (dc) and regulatory t cells (t(regs) ) are vital to the development of transplant tolerance. curcumin is a novel biological agent extracted from curcuma longa (turmeric), with anti-inflammatory and anti-oxidant activity mediated via nuclear factor (nf)-κb inhibition. we investigated the immunomodulatory effects of curcumin on human monocyte-derived and murine dc. human monocyte-derived dc (hu-mo-dc) were generated in the presence (curcdc) or absence (matdc) of 25 µm curcumin, and ... | 2010 | 21070208 |
| curcumin facilitates fibrinolysis and cellular migration during wound healing by modulating urokinase plasminogen activator expression. | urokinase plasminogen activator (upa) plays a vital role in the early phases of wound healing by aiding fibrin dissolution and promoting the migration, proliferation, and adhesion of various cells to the wound bed. the efficacy of botanicals in healing wounds is an area of active research. among these, curcumin, a yellow pigment abundant in turmeric rhizome, has been the center of extensive studies. this study focused on the effect of curcumin on upa expression and its consequence on fibrin diss ... | 2010 | 21071923 |
| chemo-resistant melanoma sensitized by tamoxifen to low dose curcumin treatment through induction of apoptosis and autophagy. | melanoma is the deadliest form of skin cancer, which is notoriously aggressive and chemo-resistant, and for which there is little effective treatment available if it goes undetected. curcumin from the turmeric spice (curcuma longa) has long been used in southeast asian medicine to alleviate ailments and cure an array of diseases and disorders. it possesses anti-inflammatory, anti-oxidant and most importantly anti-carcinogenic activity. there have been contradictory reports discussing the efficac ... | 2011 | 21088500 |
| curcumin and obesity: evidence and mechanisms. | the incidence of obesity is increasing worldwide and is hence considered a major public health concern. obesity underlies the development of several metabolic complications including cardiovascular diseases, diabetes, and inflammation. research on ways to slow the development of obesity have traditionally focused on dietary and lifestyle modifications such as restricting caloric intake and increasing physical activity. an area that has recently aroused considerable research interest is investiga ... | 2010 | 21091916 |
| effects of curcumin on the skeletal system in rats. | there is increasing interest in the discovery of natural compounds that could favorably affect the skeletal system. curcumin is a constituent of turmeric, a plant which has been used for centuries as a dietary spice and a traditional indian medicine. curcumin has been reported to affect differentiation, activity and the lifespan of osteoblasts and osteoclasts in vitro. the aim of the present study was to investigate the effects of curcumin on the skeletal system of rats in vivo. curcumin (10 mg/ ... | 2010 | 21098873 |
| suppression of mitochondrial nadp(+)-dependent isocitrate dehydrogenase activity enhances curcumin-induced apoptosis in hct116 cells. | curcumin is a polyphenol derived from the plant curcuma longa that induces apoptotic cell death in malignant cancer cell lines. it has been shown previously that mitochondrial nadp(+)-dependent isocitrate dehydrogenase (idpm) plays an essential role in defense against oxidative stress by supplying nadph for antioxidant systems. this study demonstrates that curcumin decreased the activity of idpm, both as a purified enzyme and in cultured cells. it also shows that curcumin-induced apoptosis in th ... | 2010 | 21110780 |
| anti-inflammatory and anti-oxidant properties of curcuma longa (turmeric) versus zingiber officinale (ginger) rhizomes in rat adjuvant-induced arthritis. | turmeric (rich in curcuminoids) and ginger (rich in gingerols and shogaols) rhizomes have been widely used as dietary spices and to treat different diseases in ayurveda/chinese medicine since antiquity. here, we compared the anti-inflammatory/anti-oxidant activity of these two plants in rat adjuvant-induced arthritis (aia). both plants (at dose 200 mg/kg body weight) significantly suppressed (but with different degrees) the incidence and severity of arthritis by increasing/decreasing the product ... | 2010 | 21120596 |
| bisdemethoxycurcumin protects endothelial cells against t-bhp-induced cell damage by regulating the phosphorylation level of erk1/2 and akt. | curcuminoids are the major active components extracted from curcuma longa and are well known for their antioxidant effects. previous studies have reported that the antioxidant properties of curcuminoids are mainly attributed to their free radical scavenging abilities. however, whether there are other mechanisms besides the non-enzymatic process and how they are involved, still remains unknown. in the present study, we explored the protective effects of bisdemethoxycurcumin (cur3) against tert-bu ... | 2010 | 21136025 |
| modulatory effects of garlic, ginger, turmeric and their mixture on hyperglycaemia, dyslipidaemia and oxidative stress in streptozotocin-nicotinamide diabetic rats. | spices which show hypoglycaemic, hypolipidaemic and antioxidant activities may have a role in the treatment of diabetes and its complications. the present study aimed to compare the modulatory effects of garlic, ginger, turmeric and their mixture on the metabolic syndrome and oxidative stress in streptozotocin (stz)-nicotinamide diabetic rats. diabetes was induced in overnight fasted rats by a single intraperitoneal injection of stz (65 mg/kg body weight) and nicotinamide (110 mg/kg body weight, ... | 2010 | 21144104 |
| anti-platelet effects of curcuma oil in experimental models of myocardial ischemia-reperfusion and thrombosis. | extensive research on the mechanism of action and medicinal importance of curcumin obtained from turmeric (curcuma longa) has unfolded its potential therapeutic value against many chronic ailments. curcuma oil (c.oil), the highly lipophilic component from curcuma longa has been documented for its neuroprotective efficacy against rat cerebral ischemia-reperfusion injury; however its effect on myocardial reperfusion injury remains unexplored. in the present study, effect of c.oil (500 mg/kg, po) w ... | 2010 | 21144557 |
| hazardous effects of curcumin on mouse embryonic development through a mitochondria-dependent apoptotic signaling pathway. | in this study, we examined the cytotoxic effects of curcumin, the yellow pigment of curcuma longa, on the blastocyst stage of mouse embryos, subsequent embryonic attachment, and outgrowth in vitro and in vivo implantation by embryo transfer. mouse blastocysts were incubated in medium with or without curcumin (6, 12 or 24 μm) for 24 h. cell proliferation and growth were investigated using dual differential staining, apoptosis was analyzed with terminal deoxynucleotidyl transferase-mediated dutp n ... | 2010 | 21152277 |
| anti-carcinogenic properties of curcumin on colorectal cancer. | curcumin has been used in traditional indian medicine for many centuries for its anti-inflammatory and anti-carcinogenic properties. there has been some promising research concerning curcumin as a safe therapeutic agent for many cancers, colorectal cancer being among them. this has been shown through research in cell cultures, animal models, and humans. at this time, it appears that curcumin's anti-carcinogenic properties are most likely due to its effects on multiple molecular targets, such as ... | 2010 | 21160593 |
| curcumin i protects the dopaminergic cell line sh-sy5y from 6-hydroxydopamine-induced neurotoxicity through attenuation of p53-mediated apoptosis. | oxidative stress (os) plays a pivotal role in the pathogenesis of parkinson's disease (pd). 6-hydroxydopamine (6-ohda) is a neurotoxin used to induce oxidative cell death of dopaminergic neurons in experimental models of pd. curcumin i, or diferuloylmethane is a pure compound isolated from curcuma longa linn. that has been reported to have neuroprotective properties. the precise mechanism, however, remains unclear. this study aims to elucidate the mechanisms by which curcumin i exerts its effect ... | 2010 | 21167259 |
| curcumin inhibits adipocyte differentiation through modulation of mitotic clonal expansion. | adipocyte differentiation is a key process in determining the number of mature adipocytes in the development of obesity. here, we examined the function of curcumin, a dietary polyphenol found in turmeric, and its underlying mechanisms in adipocyte differentiation. our study reveals that curcumin exerts an anti-adipogenic function both in 3t3-l1 murine cells and in human primary preadipocytes as determined by intracellular lipid accumulation assay, quantitative analysis of adipocyte marker gene e ... | 2010 | 21189228 |
| inhibitory effects of curcumin on passive cutaneous anaphylactoid response and compound 48/80-induced mast cell activation. | mast cells participate in allergies and inflammation by secreting a variety of pro-inflammatory mediators. curcumin, the active component of turmeric, is a polyphenolic phytochemical with anti-tumor, anti-inflammatory, anti-oxidative, and anti-allergic properties. the effects of curcumin on compound 48/80-induced mast cell activation and passive cutaneous anaphylactoid reactions are unknown. in this report, we investigated the influences of curcumin on the passive cutaneous anaphylactoid respons ... | 2010 | 21190003 |
| chemopreventive effect of curcuma longa linn on liver pathology in hbx transgenic mice. | unlike other forms of hepatocellular carcinoma (hcc), hcc induced by hepatitis b virus (hbv) infection shows a poor prognosis after conventional therapies. hbv induces liver cirrhosis and hcc. many researchers have made efforts to find new substances that suppress the activity of hbv. curcuma longa linn (cll) has been used for traditional medicine and food in asia, especially in india, and has shown chemopreventive effects in a hbv-related in vitro model. this in vivo study was designed to seek ... | 2010 | 21190953 |
| a polymeric nanoparticle formulation of curcumin inhibits growth, clonogenicity and stem-like fraction in malignant brain tumors. | curcumin is a polyphenolic compound derived from the indian spice turmeric. we used nanoparticle-encapsulated curcumin to treat medulloblastoma and glioblastoma cells. this formulation caused a dose-dependent decrease in growth of multiple brain tumor cell cultures, including the embryonal tumor derived lines daoy and d283med, and the glioblastoma neurosphere lines hsr-gbm1 and jhh-gbm14. the reductions in viable cell mass observed were associated with a combination of g(2)/m arrest and apoptoti ... | 2011 | 21193839 |
| effects of dietary antioxidants on the quality, fatty acid profile, and lipid oxidation of longissimus muscle in kacang goat with aging time. | thirty-two male goats were randomly assigned to four dietary treatments namely, basal diet 70% concentrate and 30% oil palm fronds (control, cn), cn + 400 mg/kg vitamin e (ve), 0.5% turmeric (tu) or 0.5% anderographis paniculata (ap). after 100 days of feeding, the goats were slaughtered and longissimus dorsi (ld) muscle was sampled. the muscle was vacuum-packaged and conditioned for 0, 7 and 14 days in a chiller (4 °c). the drip loss of the ld muscle increased (p < 0.05) with aging time. meat t ... | 2010 | 21194849 |
| plant species used in traditional smallholder dairy processing in east shoa, ethiopia. | plant species used in traditional dairy processing were studied in three districts (bosset, ada, and gimbichu) in eastern shoa, ethiopia, from october 2007 to march 2008. a total of 300 smallholders were interviewed using semi-structured questionnaires, and three focus group discussions were conducted, followed by plants specimen collection and identification. a total of 36 plant species, falling under 24 plant families, were identified. nearly half of the identified plant species had more than ... | 2011 | 21197576 |
| investigation of the apoptotic effect of curcumin in human leukemia hl-60 cells by using flow cytometry. | curcumin (diferuloylmethane), the major yellow pigment isolated from the turmeric (curcuma longa), has received much attention due to several biological properties. curcumin exhibits a variety of pharmacological effects including antitumor, anti-inflammatory, and anti-infectious activities. in the present study, the effects of curcumin on apoptosis in the acute promyelocytic human leukemia (hl-60) cells was evaluated. cytotoxic effects of curcumin on hl-60 cells were determined by mtt. hl-60 cel ... | 2010 | 21204771 |
| modulation of pentylenetetrazole-induced kindling and oxidative stress by curcumin in mice. | epilepsy is a chronic neurological disorder affecting 1% population worldwide. a number of experimental studies have reported anticonvulsant, neuroprotective and antioxidant activity of certain natural products like curcumin, an active ingredient of turmeric. the present study was designed to explore the effect of acute administration of curcumin at doses 50, 100 and 200 mg/kg, orally (p.o.) pentylenetetrazole-induced kindling in mice. further two oxidative stress markers viz., malondialdehyde ( ... | 2011 | 21211953 |
| curcumin prevents haloperidol-induced development of abnormal oro-facial movements: possible implications of bcl-xl in its mechanism of action. | curcumin (curcuma longa linn), the active component of turmeric, has been shown to be effective in ameliorating several stress and drug-induced disorders in rats and humans. however, it is unclear whether short term curcumin administration can prevent the abnormal oro-facial movements (aofm) which develop following blockade of dopamine d2 receptors by antagonist such as haloperidol. the objective of this study is to determine whether short term treatment with curcumin along with haloperidol can ... | 2011 | 21218454 |
| suppression of fatty acid synthase, differentiation and lipid accumulation in adipocytes by curcumin. | curcumin is a well-known component of the cook seasoning and traditional herb turmeric (curcuma longa), which has been reported to prevent obesity. however, the mechanism still remains to be determined. in this study, curcumin is found to be an effective inhibitor of fatty acid synthase (fas), and its effects on adipocytes are further evaluated. curcumin shows both fast-binding and slow-binding inhibitions to fas. curcumin inhibits fas with an ic₅₀ value of 26.8 μm, noncompetitively with respect ... | 2011 | 21221723 |
| curcumin protects against a53t alpha-synuclein-induced toxicity in a pc12 inducible cell model for parkinsonism. | parkinson's disease (pd) is a progressive neurodegenerative movement disorder characterized by selective loss of dopaminergic neurons and the presence of lewy bodies. the pathogenesis of pd remains incompletely understood, but it appears to involve both genetic susceptibility and environmental factors. treatment for pd that prevents neuronal death in the dopaminergic system and abnormal protein deposition in the brain is not yet available. evidence from human and animal studies has suggested tha ... | 2011 | 21237271 |
| proteomic identification of differentially expressed proteins in curcumin-treated mcf-7 cells. | curcumin (cm), a well-known dietary pigment derived from curcuma longa l., possess anticancer activities against a variety of tumors including human breast carcinoma. in combination with docetaxel, cm has been used in breast cancer management in the clinic. in order to explore the possible mechanism of anticancer activity of cm, in the present study, we aimed to identify proteins involved in the anticancer activity of cm in human breast cancer cell line mcf-7 using the two-dimensional electropho ... | 2011 | 21239154 |
| anti-proliferative potential of curcumin in androgen-dependent prostate cancer cells occurs through modulation of the wingless signaling pathway. | activation of the wingless (wnt)/ß-catenin signaling pathway contributes to prostate tumorigenesis and metastasis. depending of the stage of prostate cancer development, current drug therapies are of limited efficiency, so that prevention with natural compounds appears as an attractive strategy especially due to the slow progressive development of prostate cancer. we report here that the chemopreventive agent curcumin from the rhizome of curcuma longa was able to affect cell proliferation of and ... | 2011 | 21240460 |
| chinese herbal medicines as adjuvant treatment during chemo- or radio-therapy for cancer. | numerous studies have indicated that in cancer treatment chinese herbal medicines in combination with chemo- or radio-therapy can be used to enhance the efficacy of and diminish the side effects and complications caused by chemo- and radio-therapy. therefore, an understanding of chinese herbal medicines is needed by physicians and other health care providers. this review provides evidence for use of chinese herbal medicines as adjuvant cancer treatment during chemo- or radio-therapy. first, chin ... | 2010 | 21248427 |
| protective effect of curcumin (curcuma longa) against d-galactose-induced senescence in mice. | brain senescence plays an important role in cognitive dysfunction and neurodegenerative disorders. curcumin was reported to have beneficial effect against several neurodegenerative disorders including alzheimer's disease. therefore, the present study was conducted in order to explore the possible role of curcumin against d-galactose-induced cognitive dysfunction, oxidative damage, and mitochondrial dysfunction in mice. chronic administration of d-galactose for 6 weeks significantly impaired cogn ... | 2011 | 21253949 |
| epigenetic targets of bioactive dietary components for cancer prevention and therapy. | the emergent interest in cancer epigenetics stems from the fact that epigenetic modifications are implicated in virtually every step of tumorigenesis. more interestingly, epigenetic changes are reversible heritable changes that are not due to the alteration in dna sequence but have potential to alter gene expression. dietary agents consist of many bioactive ingredients which actively regulate various molecular targets involved in tumorigenesis. we present evidence that numerous bioactive dietary ... | 2010 | 21258631 |
| synergistic apoptotic effect of arabinoxylan rice bran (mgn-3/biobran) and curcumin (turmeric) on human multiple myeloma cell line u266 in vitro. | the present study was carried out to investigate the synergistic apoptotic potential of arabinoxylan rice bran (mgn-3/biobran) and curcumin (turmeric) on human multiple myeloma (mm) cell line u266 , in vitro. u266 cells were cultured with mgn-3 (50 or 100µg/ml) and curcumin (2.5-10µm) for 3 days. the effects of mgn-3 and curcumin on the growth and survival of the u266 cells were determined by trypan blue, mtt assay, flow cytometry analysis of cancer cell cycle, and apoptosis. expression of proap ... | 2011 | 21275460 |
| targeting cell signaling and apoptotic pathways by dietary agents: role in the prevention and treatment of cancer. | cancer is one of the leading causes of death in the united states and around the world. most modern drug-targeted therapies, besides being enormously expensive, are associated with serious side effects and morbidity. still, the search continues for an ideal treatment that has minimal side effects and is cost-effective. indeed, the design and development of chemopreventive agents that act on specific and/or multiple molecular and cellular targets is gaining support as a rational approach to preve ... | 2011 | 21294053 |
| curcumin potentiates doxorubicin-induced apoptosis in h9c2 cardiac muscle cells through generation of reactive oxygen species. | doxorubicin (dox) is a widely used chemotherapy agent. the major adverse effect of dox treatment in cancer patients is the onset of cardiomyopathy and heart failure. reactive oxygen species (ros) are proposed to be responsible for dox cardiotoxicity. curcumin, a natural compound extracted from curcuma longa l., is known for its anti-oxidant properties. it has been identified as increased apoptosis in several cancer cell lines in combination with doxorubicin, but there are few studies about the e ... | 2011 | 21295102 |
| curcumin: a review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. | curcumin (diferuloylmethane) is a polyphenol derived from the curcuma longa plant, commonly known as turmeric. curcumin has been used extensively in ayurvedic medicine for centuries, as it is nontoxic and has a variety of therapeutic properties including anti-oxidant, analgesic, anti-inflammatory and antiseptic activity. more recently curcumin has been found to possess anti-cancer activities via its effect on a variety of biological pathways involved in mutagenesis, oncogene expression, cell cyc ... | 2011 | 21299897 |
| the antihyperglycemic effect of curcumin in high fat diet fed rats. role of tnf-a and free fatty acids. | this study was conducted to investigate the effect of curcumin, obtained from curcuma longa, in comparison with rosiglitazone on the progression of insulin resistance and type 2 diabetes mellitus (t2dm) and the mechanisms underlying this effect. insulin resistance and t2dm was induced in male sprague dawley rats by high fat diet (hfd) feeding for 60 and for 75 days representing two regimens of the study, protection and treatment. prophylactic oral administration of curcumin (80 mg/kg), rosiglita ... | 2011 | 21310207 |
| curcumin induces downregulation of e2f4 expression and apoptotic cell death in hct116 human colon cancer cells; involvement of reactive oxygen species. | e2f transcription factors and their target genes have been known to play an important role in cell growth control. we found that curcumin, a polyphenolic phytochemical isolated from the plant curcuma longa, markedly suppressed e2f4 expression in hct116 colon cancer cells. hydrogen peroxide was also found to decrease e2f4 protein level, indicating the involvement of reactive oxygen species (ros) in curucmin-induced downregulation of e2f4 expression. involvement of ros in e2f4 downregulation in re ... | 2010 | 21311680 |
| curcumin nanoparticles: preparation, characterization, and antimicrobial study. | curcumin is a highly potent, nontoxic, bioactive agent found in turmeric and has been known for centuries as a household remedy to many ailments. the only disadvantage that it suffers is of low aqueous solubility and poor bioavailability. the aim of the present study was to develop a method for the preparation of nanoparticles of curcumin with a view to improve its aqueous-phase solubility and examine the effect on its antimicrobial properties. nanoparticles of curcumin (nanocurcumin) were prepa ... | 2011 | 21322563 |
| curcumin suppresses proliferation and induces apoptosis in human biliary cancer cells through modulation of multiple cell signaling pathways. | cholangiocarcinoma (cca) is a tumor with poor prognosis that is resistant to all currently available treatments. whether curcumin, a nutraceutical derived from turmeric (curcuma longa), has potential therapeutic activity against human cca was investigated using three cca cell lines (kku100, kku-m156 and kku-m213). examination of mitochondrial dehydrogenase activity, phosphatidylserine externalization, esterase staining, caspase activation and poly-adenosine diphosphate ribose polymerase cleavage ... | 2011 | 21325634 |
| curcumin prevents dna damage and enhances the repair potential in a chronically arsenic-exposed human population in west bengal, india. | induction of oxidative stress and inhibition of dna repair are possible modes of arsenic-induced carcinogenesis. in west bengal, india, several districts contain high levels of arsenic, which are far above the who-recommended standard. prevention of arsenic-induced oxidative stress and induction of repair enzymes by curcumin, an active ingredient of turmeric, may be an effective strategy to combat the adverse effects of arsenic. this study aimed at observing the role of curcumin in reducing 8-hy ... | 2011 | 21332098 |
| turmeric and laurel aqueous extracts exhibit in vitro anti-atherosclerotic activity and in vivo hypolipidemic effects in a zebrafish model. | culinary herbs and spices have been widely used for their hypoglycemic, lipid-lowering, and anti-inflammatory activities. this study examined the physiologic activity of hydrophilic components using extracts of turmeric or laurel leaf powder. aqueous extracts of turmeric and laurel showed potent inhibitory activity against fructose-mediated glycation with antioxidant ability against low-density lipoprotein (ldl) oxidation and radical scavenging activity. the turmeric and laurel extracts had pote ... | 2011 | 21332404 |
| curcuminoid binds to amyloid-ß1-42 oligomer and fibril. | studies of alzheimer's disease (ad) strongly support the hypothesis that amyloid-ß (aß) deposition in the brain is the initiating event in the progression of ad. aß peptides easily form long insoluble amyloid fibrils, which accumulate in deposits known as senile plaques. on the other hand, recent work indicated that soluble aß oligomers, rather than monomers or insoluble aß fibrils, might be responsible for neuronal and synaptic dysfunction in ad. curcumin, a low molecular weight yellow-orange p ... | 2011 | 21335654 |
| can curcumin provide an ideal contraceptive? | the population explosion, unintended pregnancies, sexually transmitted diseases, and cancer (cervical and breast) continue to cause major public health issues worldwide. curcumin, diferuloyl methane, the yellow pigment component of the curry spice turmeric (curcuma longa), has immense biological effects and has recently drawn considerable attention. curcumin has antibacterial, antiviral, antiinflammatory, and anticancer properties. it has shown a lack of toxicity in animals and human clinical tr ... | 2011 | 21337449 |
| repellent, larvicidal and pupicidal properties of essential oils and their formulations against the housefly, musca domestica. | the essential oils of six plant species [peppermint, mentha piperita, and bergamot mint, mentha citrata (both, lamiales: lamiaceae); blue gum, eucalyptus globulus (myrtales: myrtaceae); lemongrass, cymbopogon citratus, and khus grass, vetiver zizanoides (both, poales: poaceae), and turmeric, curcuma longa (ziniberales: zingiberaceae)] were screened for repellent, larvicidal and pupicidal activities against the housefly, musca domestica l. (diptera: muscidae). subsequently, emulsifiable concentra ... | 2011 | 21338379 |
| effect of maternal fluoride exposure on developing cns of rats: protective role of aloe vera, curcuma longa and ocimum sanctum. | fluoride is toxic to neuronal development and its excessive intake during pregnancy cause adverse effects on neonatal development. the present study examined the presence of oxidative stress during maternal exposure of fluoride and the therapeutic strategy of aloe vera, curcuma longa and ocimum sanctum extracts in functional prevention of fluoride led oxidative stress. the pregnant wistar rats were exposed to 100 ppm fluoride in drinking water and pups born to them were supplemented with phytoex ... | 2010 | 21341542 |
| chemoprevention by essential oil of turmeric leaves (curcuma longa l.) on the growth of aspergillus flavus and aflatoxin production. | turmeric is well known for a wide range of medicinal properties. essential oil of turmeric leaves (curcuma longa l.) were evaluated at varying concentrations of 0.01, 0.05, 0.1, 0.5, 0.75, 1.0 and 1.5% (v/v) in yeast extract sucrose (yes) broth inoculated with spore suspension of aspergillus flavus of 10(6)conidia/ml. these were evaluated for their potential in the control of aflatoxigenic fungus a. flavus and aflatoxin production. turmeric leaf oil exhibited 95.3% and 100% inhibition of toxin p ... | 2011 | 21354246 |
| neuroprotection by spice-derived nutraceuticals: you are what you eat! | numerous lines of evidence indicate that chronic inflammation plays a major role in the development of various neurodegenerative diseases, including alzheimer's disease, parkinson's disease, multiple sclerosis, brain tumor, and meningitis. why these diseases are more common among people from some countries than others is not fully understood, but lifestyle factors have been linked to the development of neurodegenerative diseases. for example, the incidence of certain neurodegenerative diseases a ... | 2011 | 21360003 |
| mining and characterization of est derived microsatellites in curcuma longa l. | turmeric (curcuma longa l.) (family: zingiberaceae) is a perennial rhizomatous herbaceous plant often used as a spice since time immemorial. turmeric plants are also widely known for its medicinal applications. recently est-derived ssrs (simple sequence repeats) are a free by-product of the currently expanding est (expressed sequence tag) databases. ssrs have been widely applied as molecular markers in genetic studies. development of high throughput method for detection of ssrs has given a new d ... | 2010 | 21364792 |
| clinical inquiry. does turmeric relieve inflammatory conditions? | yes, but data aren't plentiful. limited evidence suggests that turmeric and its active compound, curcumin, are effective for rheumatoid arthritis and other inflammatory conditions (strength of recommendation [sor]: c, primarily low-quality cohort studies with small patient numbers). curcumin has shown limited benefit for patients with psoriasis, inflammatory bowel disease (ibs), inflammatory eye diseases, familial adenomatous polyposis, and kidney transplantation (sor: b, small, short randomized ... | 2011 | 21369559 |
| bioavailability enhancement of curcumin by complexation with phosphatidyl choline. | curcumin is a major constituent of rhizomes of curcuma longa. pharmacokinetic studies of curcumin reveal its poor absorption through intestine. objective of the present study was to enhance bioavailability of curcumin by its complexation with phosphatidyl choline (pc). complex of curcumin was prepared with pc and characterized on the basis of solubility, melting point, differential scanning calorimetry, thin layer chromatography, and infrared spectroscopic analysis. everted intestine sac techniq ... | 2010 | 21374628 |
| curcumin induces stress response and hormetically modulates wound healing ability of human skin fibroblasts undergoing ageing in vitro. | wound healing becomes impaired in several diseases and during ageing. a commonly used model for the study of wound healing is a scratched monolayer of cells in vitro, which is convenient for the analysis of the cellular and molecular changes occurring during the two phases of wound healing, namely cell migration and cell proliferation. cell migration, which is the primary event to occur during initial wound healing, is inversely dependent on the number of focal adhesions (fa) that attach cells t ... | 2011 | 21380847 |
| exploiting est databases for the mining and characterization of short sequence repeat (ssr) markers in catharanthus roseus l. | periwinkle (catharanthus roseus l.) (family: apocyanaceae) is a ornamental plants with great medicinal properties. although it is represented by seven species, little work has been carried out on its genetic characterization due to non-availability of reliable molecular markers. simple sequence repeats (ssrs) have been widely applied as molecular markers in genetic studies. with the rapid increase in the deposition of nucleotide sequences in the public databases and advent of bioinformatics tool ... | 2011 | 21383904 |
| curcumin inhibition of the functional interaction between integrin α6β4 and the epidermal growth factor receptor. | the functional interaction between integrin α6β4 and growth factor receptors has been implicated in key signaling pathways important for cancer cell function. however, few attempts have been made to selectively target this interaction for therapeutic intervention. previous studies showed that curcumin, a yellow pigment isolated from turmeric, inhibits integrin α6β4 signaling important for breast carcinoma cell motility and invasion, but the mechanism is not currently known. to address this issue ... | 2011 | 21388972 |
| whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions. | in traditional medicine whole plants or mixtures of plants are used rather than isolated compounds. there is evidence that crude plant extracts often have greater in vitro or/and in vivo antiplasmodial activity than isolated constituents at an equivalent dose. the aim of this paper is to review positive interactions between components of whole plant extracts, which may explain this. | 2011 | 21411015 |
| curcumin attenuates lipopolysaccharide-induced renal inflammation. | renal inflammation is the main pathological change in many acute and chronic kidney diseases. curcumin, a yellow pigment present in the rhizome of turmeric (curcuma longa l. zingiberaceae), was found to be a potential anti-inflammatory agent. the present study aimed to investigate the effects of curcumin on the inflammation of mice kidney and cultured renal tubular epithelial cells (hk-2 cells) induced by lipopolysaccharide (lps) and to explore the mechanism. curcumin was injected intraperitonea ... | 2011 | 21415532 |
| safety of herbal products in thailand: an analysis of reports in the thai health product vigilance center database from 2000 to 2008. | the use of herbal products continues to expand rapidly across the world and concerns regarding the safety of these products have been raised. in thailand, thai vigibase, developed by the health product vigilance center (hpvc) under the thai food and drug administration, is the national database that collates reports from health product surveillance systems and programmes. thai vigibase can be used to identify signals of adverse events in patients receiving herbal products. | 2011 | 21417506 |
| analysis and stability of the constituents of curcuma longa and harpagophytum procumbens tinctures by hplc-dad and hplc-esi-ms. | in the present study two methods based on liquid chromatography with diode array detection (hplc-dad) coupled to an electrospray ionisation (esi-ms) interface were developed for the determination of constituents in the tinctures (60%, v/v, der 1:5) of turmeric (curcuma longa l.) and devil's claw (harpagophytum procumbens l.). the developed simple and effective assays permitted the quality control of both tinctures. the aim of this work was to assess the qualitative and quantitative profile of th ... | 2011 | 21420820 |
| genetic diversity of turmeric germplasm (curcuma longa; zingiberaceae) identified by microsatellite markers. | turmeric (curcuma longa) is a triploid, vegetatively propagated crop introduced early during the colonization of brazil. turmeric rhizomes are ground into a powder used as a natural dye in the food industry, although recent research suggests a greater potential for the development of drugs and cosmetics. in brazil, little is known about the genetic variability available for crop improvement. we examined the genetic diversity among turmeric accessions from a brazilian germplasm collection compris ... | 2011 | 21425092 |
| new polymorphs of curcumin. | two new crystalline polymorphs and an amorphous phase of the active curcuminoid ingredient in turmeric are reported. curcumin polymorph 2 has higher dissolution rate and better solubility than the known polymorph 1. | 2011 | 21431190 |
| curcumin improves prostanoid ratio in diabetic mesenteric arteries associated with cyclooxygenase-2 and nf-κb suppression. | curcumin, the active ingredient from turmeric rhizomes, has been shown to have a wide range of pharmacological properties including antioxidant and anti-inflammatory effects. curcumin has been reviewed for its multiple molecular action on inhibiting tumor angiogenesis via its mechanisms of cyclooxygenase (cox)-2, and vascular endothelial growth factor (vegf) inhibition. in this present study, we aimed to assess the effects of curcumin on preventing diabetes-induced vascular dysfunction in associ ... | 2010 | 21437112 |
| new mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases. | a metabolic abnormality such as obesity is a major obstacle in the maintenance of the human health system and causes various chronic diseases including type 2 diabetes, hypertension, cardiovascular diseases, as well as various cancers. this study was designed to summarize the recent scientific knowledge regarding the anti-obesity role of curcumin (diferuloylmethane), which is isolated from the herb curcuma longa, known to possess anti-inflammatory activities. however, little is known about its e ... | 2011 | 21442412 |
| curcumin disrupts uterine leiomyosarcoma cells through akt-mtor pathway inhibition. | uterine leiomyosarcoma generally has an unfavorable response to standard chemotherapy. the loss of pten which results in constitutive akt-mtor activation causes an increase in leiomyosarcoma formation in mice. the active ingredient derived from the herb curcuma longa, curcumin, shows antitumor properties in a variety of cancer cell lines by altering a number of oncogenic pathways. to explore the possibility of curcumin as an alternative to standard chemotherapy, we decided to investigate curcumi ... | 2011 | 21450334 |
| evaluation of turmeric extract on performance indices impressed by induced aflatoxicosis in broiler chickens. | the purpose of this study was evaluation of ethanolic turmeric extract (ete; curcuma longa) effect on overall performance including body weight (bw), body weight gain (bwg), feed intake and feed conversion ratio (fcr) weekly and cumulative for a period of 4 weeks with 300 commercial broiler chicks (ross strain). these chicks were randomly divided into four groups with three replicates of 15 chicks in each replicate. in group a, chickens were fed a basal diet, in group b, chickens were fed a basa ... | 2011 | 21450929 |
| bioactive antioxidant mixtures promote proliferation and migration on human oral fibroblasts. | antioxidants (aos) are the first line of defence against free radical damage and are critical for maintaining optimum health and well being. the need for aos becomes even more critical with increased exposure to free radicals generated by pollution, cigarette smoke, drugs, illness, stress and exercise. antioxidant supplementation is an excellent way of improving free radical protection. the aim of this study was to provide cytotoxicity, proliferation and migration data on the in vitro effects of ... | 2011 | 21458775 |
| involvement of ros in curcumin-induced autophagic cell death. | many anticancer agents as well as ionizing radiation have been shown to induce autophagy which is originally described as a protein recycling process and recently reported to play a crucial role in various disorders. in hct116 human colon cancer cells, we found that curcumin, a polyphenolic phytochemical extracted from the plant curcuma longa, markedly induced the conversion of microtubule-associated protein 1 light chain 3 (lc3)-i to lc3-ii and degradation of sequestome-1 (sqstm1) which is a ma ... | 2011 | 21461234 |
| curcumin and liver cancer: a review. | primary liver cancer, also known as hepatocellular carcinoma (hcc), is one of the most lethal cancers having worldwide prevalence. although most hcc cases are reported in the developing countries of asia and africa, there has been an alarming increase in hcc cases in western europe as well as united states. chronic liver diseases, viral hepatitis, alcoholism as well as dietary carcinogens, such as aflatoxins and nitrosoamines, contribute to hcc. liver transplantation as well as surgical resectio ... | 2012 | 21466422 |
| discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism. | polyphenol curcumin, a yellow pigment, derived from the rhizomes of a plant (curcuma longa linn) is a natural antioxidant exhibiting a variety of pharmacological activities and therapeutic properties. it has long been used as a traditional medicine and as a preservative and coloring agent in foods. here, curcumin-converting microorganisms were isolated from human feces, the one exhibiting the highest activity being identified as escherichia coli. we are thus unique in discovering that e. coli wa ... | 2011 | 21467222 |
| suppression of growth and invasive behavior of human prostate cancer cells by prostacaid™: mechanism of activity. | since the use of dietary supplements as alternative treatments or adjuvant therapies in cancer treatment is growing, a scientific verification of their biological activity and the detailed mechanisms of their action are necessary for the acceptance of dietary supplements in conventional cancer treatments. in the present study we have evaluated the anti-cancer effects of dietary supplement prostacaid™ (pc) which contains mycelium from medicinal mushrooms (ganoderma lucidum, coriolus versicolor, p ... | 2011 | 21468543 |
| chronic dietary supplementation with turmeric protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-mediated neurotoxicity in vivo: implications for parkinson's disease. | multiple pathways including oxidative stress and mitochondrial damage are implicated in neurodegeneration during parkinson's disease (pd). the current pd drugs provide only symptomatic relief and have limitations in terms of adverse effects and inability to prevent neurodegeneration. therefore, there is a demand for novel compound(s)/products that could target multiple pathways and protect the dying midbrain dopaminergic neurons, with potential utility as adjunctive therapy along with convention ... | 2011 | 21473798 |
| physiological and therapeutical roles of ginger and turmeric on endocrine functions. | the natural product ginger (zingiber officinale) has active constituents gingerol, shogaol and zerumbone, while turmeric (curcuma longa) contains three active major curcuminoids, namely, curcumin, demethoxycurcumin, and bisdemethoxycurcumin. they have the same scientific classification and are reported to have anti-inflammatory and many therapeutic effects. this article reviews the physiological and therapeutic effects of ginger and turmeric on some endocrine gland functions, and signal pathways ... | 2011 | 21476200 |
| hypomethylation effects of curcumin, demethoxycurcumin and bisdemethoxycurcumin on wif-1 promoter in non-small cell lung cancer cell lines. | the tumor suppressor gene wnt inhibitory factor-1 (wif-1) has been found to be promoter hypermethylated and silenced in lung cancer cell lines and tissues. curcuminoids are major active components of the spice turmeric, and have recently been reported to be potential hypomethylation agents. in the present study, the hypomethylation effects of three major curcuminoids, curcumin, demethoxycurcumin and bisdemethoxycurcumin, were compared in vitro using elisa, and their demethylation potential was c ... | 2011 | 21484077 |
| synergistic effect of curcumin and cisplatin via downregulation of thymidine phosphorylase and ercc1. | curcumin (diferuloylmethane), a phenolic compound obtained from the rhizome of curcuma longa, is known to have antiproliferative and antitumor properties. thymidine phosphorylase (tp), an enzyme of the pyrimidine salvage pathway, is considered an attractive therapeutic target and its expression could suppress cancer cell death induced by dna damage agents. excision repair cross-complementary 1 (ercc1) is a protein involved the process of nucleotide excision repair. the ercc1 gene is expressed at ... | 2011 | 21493726 |
| low-dose curcumin leads to the inhibition of tumor growth via enhancing ctl-mediated antitumor immunity. | curcumin, a yellow pigment extracted from turmeric, is widely used to inhibit tumor progression. since it can either promote or suppress the immune system, how curcumin affects the immune system in tumor-bearing bodies is not yet clear. our study found that tumor-bearing mice treated consecutively once a day with low-dose curcumin for ten days led to a retarded tumor growth and a longer survival, which might be contributed to t cell-mediated adaptive immune response. the in vitro study also show ... | 2011 | 21497674 |
| curcumin enhanced adriamycin-induced human liver-derived hepatoma g2 cell death through activation of mitochondria-mediated apoptosis and autophagy. | hepatocellular carcinoma (hcc) is the fifth most common cancer and the third leading cancer killer in the world. adriamycin (adm) is a widely used anti-cancer drug. however, the efficacy is low since high dose of adm causes toxicity to normal tissues. curcumin, derived from turmeric (curcumin longa), has shown its therapeutic potential against hcc. here, we aim to investigate the effects of curcumin combined with adm on human liver-derived hepatoma g2 (hepg2) cell death. we found that combinatio ... | 2011 | 21514382 |
| epigenetic changes induced by curcumin and other natural compounds. | epigenetic regulation, which includes changes in dna methylation, histone modifications, and alteration in microrna (mirna) expression without any change in the dna sequence, constitutes an important mechanism by which dietary components can selectively activate or inactivate gene expression. curcumin (diferuloylmethane), a component of the golden spice curcuma longa, commonly known as turmeric, has recently been determined to induce epigenetic changes. this review summarizes current knowledge a ... | 2011 | 21516481 |
| therapeutic potential of dietary polyphenols against brain ageing and neurodegenerative disorders. | in recent years there has been a growing interest, supported by a large number of experimental and epidemiological studies, in the beneficial effects of some commonly used food-derived products in preventingvarious age-related pathologic conditions, ranging from cancer to neurodegenerative diseases. spices and herbs often contain active phenolic substances endowed with potent antioxidative and chemopreventive properties. curcumin is a phytochemical compound extracted from the rhizome of curcuma ... | 2010 | 21520701 |
| curcumin induces dna damage and caffeine-insensitive cell cycle arrest in colorectal carcinoma hct116 cells. | curcumin (cur), a polyphenol derived from the plant curcuma longa, displays potential anti-cancer activity. one of the mechanisms stems from its ability to elicit cell cycle arrest followed by suppression of cell proliferation. herein, we reported that cur significantly induced dna damage and mediated s and g2/m phase arrest in colorectal carcinoma hct116 cells. unlike etoposide, a classical topoisomerase ii inhibitor, cur-triggered g2/m phase arrest was hardly reversed by caffeine (caff) which ... | 2011 | 21526346 |
| srebp2 mediates the modulation of intestinal npc1l1 expression by curcumin. | curcumin, the major phenolic compound in the spice turmeric, exhibits numerous biological effects including lowering plasma cholesterol and preventing diet-induced hypercholesterolemia. the mechanism underlying hypocholesterolemic effect of curcumin are not fully understood. in this regard, intestinal niemann-pick c1-like 1 (npc1l1) cholesterol transporter, the molecular target of intestinal cholesterol absorption inhibitor ezetimibe, plays an essential role in the maintenance of cholesterol hom ... | 2011 | 21527728 |
| attenuation of fatty liver and prevention of hypercholesterolemia by extract of curcuma longa through regulating the expression of cyp7a1, ldl-receptor, ho-1, and hmg-coa reductase. | the extract of curcuma longa, better known as turmeric, was orally administered to experimental rats that were fed a high-cholesterol diet to investigate whether it could regulate plasma lipids and cholesterol levels and possibly improve hepatic conditions. with turmeric supplements, rats showed a significant decrease in total plasma cholesterol and low-density lipoprotein cholesterol but an increase in high-density lipoprotein cholesterol when compared with rats that were fed a high-cholesterol ... | 2011 | 21535835 |
| curcumin acts synergistically with fluconazole to sensitize a clinical isolate of candida albicans showing a mdr phenotype. | the primary objective of this work was to evaluate the capability of curcumin, a natural compound found in the curcuma longa plant, to sensitize a clinical isolate of candida albicans, which was found to have a high resistance to fluconazole. in addition, we assessed whether the resistance of this isolate was the result of the existence of efflux pumps, which could confer a multiple drug resistance phenotype. to evaluate azole resistance, we used the clinical laboratory standard institute (clsi) ... | 2011 | 21539505 |
| protective effects of the dietary supplementation of turmeric (curcuma longa l.) on sodium arsenite-induced biochemical perturbation in mice. | the present study was undertaken to evaluate the protective effect of turmeric powder on arsenic toxicity through mice model. swiss albino male mice were divided into four groups. the first group was used as control, while groups 2, 3, and 4 were treated with turmeric powder (t, 50 mg/kg body weight/day), sodium arsenite (sa, 10 mg/kg body weight/day) and turmeric plus sa (t+sa), respectively. results showed that oral administration of sa reduced the weight gain of the mice compared to the contr ... | 2010 | 21548544 |
| effects of thai medicinal herb extracts with anti-psoriatic activity on the expression on nf-κb signaling biomarkers in hacat keratinocytes. | psoriasis is a chronic inflammatory skin disorder characterized by rapid proliferation of keratinocytes and incomplete keratinization. discovery of safer and more effective anti-psoriatic drugs remains an area of active research at the present time. using a hacat keratinocyte cell line as an in vitro model, we had previously found that ethanolic extracts from three thai medicinal herbs, namely alpinia galanga, curcuma longa and annona squamosa, possessed anti-psoriatic activity. in the current s ... | 2011 | 21555979 |
| kinase gene expression and subcellular protein expression pattern of protein kinase c isoforms in curcumin-treated human hepatocellular carcinoma hep 3b cells. | curcumin, a yellow component of turmeric or curry powder, has been demonstrated to exhibit anti-carcinogenic effects in vitro, in vivo, and in human clinical trials. one of its molecular targets is protein kinase c (pkc) which has been reported to play essential roles in apoptosis, cell proliferation, and carcinogenesis. in this study, pkc mrna expression was significantly inhibited in curcumin-treated human hepatocellular carcinoma (hcc) hep 3b cells identified using a kinase cdna microarray. f ... | 2011 | 21556896 |
| contact depigmentation induced by propyl gallate. | we report a 41-year-old woman who developed contact depigmentation at several body sites after using lipstick, liquid kumkum (a colouring usually made from turmeric or saffron used for social/religious markings), and plastic or rubber slippers (flip-flops). propyl gallate, a common ingredient to all and a previously undocumented depigmenting agent, was incriminated on patch testing with the indian standard series. | 2011 | 21564173 |
| combined treatment of curcumin and small molecule inhibitors suppresses proliferation of a549 and h1299 human non-small-cell lung cancer cells. | curcumin (diferuloylmethane) is a phenolic compound present in turmeric and is ingested daily in many parts of the world. curcumin has been reported to cause inhibition on proliferation and induction of apoptosis in many human cancer cell lines, including non-small cell lung cancer cells (nsclc). however, the clinical application of curcumin is restricted by its low bioavailability. in this report, it was observed that combined treatment of a low dosage of curcumin (5-10 µm) with a low concentra ... | 2011 | 21567511 |
| safety assessment of a solid lipid curcumin particle preparation: acute and subchronic toxicity studies. | curcumin, a polyphenol, is obtained from turmeric, the ground rhizomes of curcuma longa l. extensive research over the past half century has revealed several health benefits of curcumin. the objective of the present study was to investigate potential adverse effects, if any, of a novel solid lipid curcumin particle (slcp) preparation in rats following acute and subchronic administration. the oral ld(50) of the preparation in rats as well as in mice was found to be greater than 2000mg/kg body wei ... | 2011 | 21571027 |
| umbilical cord-cutting practices and place of delivery in bangladesh. | to investigate place of delivery, umbilical cord-cutting instruments used, and substances applied to the cord stump in bangladesh. | 2011 | 21571269 |
| ethanol extracts of black pepper or turmeric down-regulated sirt1 protein expression in daudi culture cells. | sirt1 is a mammalian candidate molecule involved in longevity and diverse metabolic processes. the present study aimed to determine the effects of certain herbs and spices on sirt1 expression. human cell lines daudi, jurkat, u937 and k562 were cultured in rpmi-1640. herb and spice powders were prepared and the supernatants were collected. rt-pcr was used to quantify the expression level of the gene. protein samples were then analyzed by western blotting. western blotting revealed the down-regula ... | 2011 | 21573505 |
| curcumin suppresses growth of mesothelioma cells in vitro and in vivo, in part, by stimulating apoptosis. | malignant pleural mesothelioma (mpm) is an aggressive, asbestos-related malignancy of the thoracic pleura. although, platinum-based agents are the first line of therapy, there is an urgent need for second-line therapies to treat the drug-resistant mpm. cell cycle as well as apoptosis pathways are frequently altered in mpm and thus remain attractive targets for intervention strategies. curcumin, the major component in the spice turmeric, alone or in combination with other chemotherapeutics has be ... | 2011 | 21594647 |
| curcumin reduces expression of bcl-2, leading to apoptosis in daunorubicin-insensitive cd34+ acute myeloid leukemia cell lines and primary sorted cd34+ acute myeloid leukemia cells. | abstract: background: acute myeloid leukemia (aml) is an immunophenotypically heterogenous malignant disease, in which cd34 positivity is associated with poor prognosis. cd34+ aml cells are 10-15-fold more resistant to daunorubicin (dnr) than cd34- aml cells. curcumin is a major component of turmeric that has shown cytotoxic activity in multiple cancers; however, its anti-cancer activity has not been well studied in dnr-insensitive cd34+ aml cells. the aim of this study was to therefore to explo ... | 2011 | 21595920 |
| encapsulation of curcumin in self-assembling peptide hydrogels as injectable drug delivery vehicles. | curcumin, a hydrophobic polyphenol, is an extract of turmeric root with antioxidant, anti-inflammatory and anti-tumorigenic properties. its lack of water solubility and relatively low bioavailability set major limitations for its therapeutic use. in this study, a self-assembling peptide hydrogel is demonstrated to be an effective vehicle for the localized delivery of curcumin over sustained periods of time. the curcumin-hydrogel is prepared in-situ where curcumin encapsulation within the hydroge ... | 2011 | 21601921 |
| curcumin sensitizes acute promyelocytic leukemia cells to unfolded protein response-induced apoptosis by blocking the loss of misfolded n-cor protein. | apl (acute promyelocytic leukemia) is characterized by accumulation of apoptosis-resistant immature promyelocytic cells in the bone marrow and peripheral blood. we have shown that endoplasmic reticulum-associated degradation (erad) and protease-mediated degradation of misfolded nuclear receptor co-repressor (n-cor) confer resistance to unfolded protein response (upr)-induced apoptosis in apl. these findings suggest that therapeutic inhibition of n-cor misfolding or degradation may promote growth ... | 2011 | 21602299 |