Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| epidemiologic association of chlamydia pneumoniae and atherosclerosis: the initial serologic observation and more. | about 70% of persons with acute myocardial infarction (ami) show a seroresponse to a chlamydial lipopolysaccharide (lps) epitope. elevated titers against chlamydia pneumoniae in sera from such patients point to an exacerbation in a chronic infection as does a change in the nature of immune complexes containing chlamydial lps. the presence of antibodies to c. pneumoniae proteins in immune complexes suggests an intimate association of the pathogen with the vascular system. in the first prospective ... | 2000 | 10839725 |
| chlamydia pneumoniae and other risk factors for atherosclerosis. | seroepidemiologic studies have provided information on the association of chlamydia pneumoniae with the classical risk factors of coronary heart disease (chd). c. pneumoniae infections are more common in smokers than in nonsmokers, suggesting that smoking predisposes to the development of chronic infection. infections may also affect lipid metabolism. in persons with acute pneumonia caused by c. pneumoniae, high-density lipoprotein (hdl) values are lower and triglyceride values higher than seen ... | 2000 | 10839726 |
| chlamydia pneumoniae and atherosclerotic risk in populations: the role of seroepidemiology. | while seroepidemiologic studies first suggested a possible association of prior infection with chlamydia pneumoniae and atherosclerotic risk, the contribution of seroepidemiologic studies of c. pneumoniae and atherosclerotic risk remains a source of controversy, in part because the reported findings appear inconsistent. in general, cross-sectional studies of c. pneumoniae and atherosclerotic risk suggest an association, but recent reports from several prospective studies failed to demonstrate as ... | 2000 | 10839727 |
| the microimmunofluorescence test for chlamydia pneumoniae infection: technique and interpretation. | a brief description of current procedures for the chlamydia microimmunofluorescence (mif) test is presented. to date, use of mif serology with chlamydia pneumoniae (twar) antigen has provided the most sensitive and specific method for diagnosis of acute twar infection. in primary infections, the twar igm antibody response is longer lasting and igg antibody is slower to develop compared with chlamydia trachomatis infection. unlike other chlamydia species, only a single serovar for c. pneumoniae h ... | 2000 | 10839728 |
| chlamydia pneumoniae serology: interlaboratory variation in microimmunofluorescence assay results. | the lack of standardization in chlamydia serology has made interpretation of published data difficult. this study was initiated to determine the extent of interlaboratory variation of microimmunofluorescence (mif) test results for the serodiagnosis of chlamydia pneumoniae infections. identical panels of 22 sera were sent to 14 laboratories in eight countries for the determination of igg and igm antibodies by mif. although there was extensive variation in the numeric titer values, the overall per ... | 2000 | 10839729 |
| collaborative multidisciplinary workshop report: the role of epidemiology studies in determining a possible relationship between chlamydia pneumoniae infection and atherothrombotic diseases. | 2000 | 10839730 | |
| detection of chlamydia pneumoniae in arterial tissues. | in literature in which detection of chlamydia pneumoniae in the artery is described, the methods used were immunocytochemistry (icc), polymerase chain reaction (pcr), electron microscopy, and isolation. these studies demonstrated the presence of the organism in atheromatous lesions. the organism was detected frequently by icc and pcr in atheromatous tissues (approximately 50% of subjects) but rarely in normal arteries (approximately 1% of subjects). there has been poor correlation between detect ... | 2000 | 10839731 |
| chlamydia pneumoniae in atherosclerotic tissue. | the majority of almost 30 publications from 1992 to 1999 describe chlamydia pneumoniae organisms in atherosclerotic lesions of various major arteries. in the first study in the united kingdom, c. pneumoniae was found in the aorta and femoral and iliac arteries. in a subsequent study, the organism was detected in arteries of subjects as young as 15 years. in a collaborative investigation, 71% of atheromatous arteries taken at autopsy from white south african subjects were c. pneumoniae positive c ... | 2000 | 10839732 |
| chlamydia pneumoniae in atherosclerotic and nonatherosclerotic tissue. | the positivity rate and localization of chlamydia pneumoniae were investigated in atherosclerotic and nonatherosclerotic tissues by immunohistochemistry, polymerase chain reaction, and cell culture. in total, 67 atheromatous plaques from japanese symptomatic patients and 110 nonatherosclerotic tissues and organs were evaluated. of these, 62% of atherosclerotic plaques from symptomatic patients were infected with c. pneumoniae compared with just 2% of nonatherosclerotic tissues. immunohistochemic ... | 2000 | 10839733 |
| chlamydia pneumoniae detection in atherosclerotic plaques in italy. | italian investigations have shown an association between chlamydia pneumoniae infection and atherosclerosis. with the use of several diagnostic techniques, including serology, a microimmunofluorescence test, and nucleic acid amplification methods, a temporal association was found between acute c. pneumoniae reinfection and acute myocardial infarction, suggesting that an acute infection superimposed on a chronic or latent infection may trigger the onset of acute myocardial infarction. c. pneumoni ... | 2000 | 10839734 |
| specificity of detection of chlamydia pneumoniae in cardiovascular atheroma. | chlamydia pneumoniae is commonly detected in atherosclerotic plaque but the frequency of detection in non-cardiovascular (cv) tissues has not been well determined. in this study, archival autopsy tissue specimens from both cv and non-cv sites from 38 patients were tested by polymerase chain reaction and immunocytochemistry to detect c. pneumoniae. in addition, 33 surgical granuloma biopsy specimens were also tested. c. pneumoniae was detected most frequently in coronary artery tissue (34%) but w ... | 2000 | 10839735 |
| detection of chlamydia pneumoniae within peripheral blood monocytes of patients with unstable angina or myocardial infarction. | because individual diagnoses of vascular infection with chlamydia pneumoniae depend entirely on surgically removed tissues, a better assay to predict vascular infection is needed. polymerase chain reaction detection of chlamydial dna was applied to cd14-positive cells collected from 238 patients with angiographically identified unstable angina or acute myocardial infarction. c. pneumoniae was detected in 52 (28%) of 188 persons with unstable angina and in 13 (26%) of 50 persons with myocardial i ... | 2000 | 10839736 |
| polymerase chain reaction detection of chlamydia pneumoniae in circulating white blood cells. | several recently published studies suggest that chlamydia pneumoniae may represent a risk factor for atherosclerosis or its complications. in order to establish whether c. pneumoniae is causally linked to atherosclerotic diseases, clinical intervention trials may be needed. however, to identify eligible subjects with a persistent c. pneumoniae infection and to monitor the effect of antibiotic therapy, there is a need for a reliable diagnostic marker. blood-based polymerase chain reaction assays ... | 2000 | 10839737 |
| antibiotic susceptibility of chlamydia pneumoniae. | 2000 | 10839738 | |
| potential for antimicrobial resistance in chlamydia pneumoniae. | antimicrobial resistance has not yet been described in wild type chlamydia pneumoniae isolates, nor has selective emergence of resistance in the laboratory after exposure to subinhibitory concentrations of antibiotic. however, few clinical isolates have been tested for resistance, especially strains with resistance phenotypes (i.e., those associated with clinical failure or persistence). more widespread testing of such strains is needed. further understanding of antimicrobial resistance in chlam ... | 2000 | 10839739 |
| collaborative multidisciplinary workshop report: detection, culture, serology, and antimicrobial susceptibility testing of chlamydia pneumoniae. | 2000 | 10839740 | |
| growth in vascular cells and cytokine production by chlamydia pneumoniae. | the proposed pathogenesis of chlamydia pneumoniae in atherosclerosis is supported by the finding that c. pneumoniae can initiate and sustain growth in human vascular cells. in vitro growth of c. pneumoniae is found in macrophages, peripheral blood monocyte (pbmc)-derived macrophages, endothelial cells, and aortic artery smooth muscle cells. u-937 macrophages infected with c. pneumoniae are capable of transmitting the infection to human coronary artery endothelial cells (caec) with direct cellula ... | 2000 | 10839742 |
| interactions of chlamydia pneumoniae with human endothelial cells. | in order to fulfill the "biological plausibility" criterion of a role for infection with chlamydia pneumoniae in the pathogenesis of human atherosclerosis, detailed studies on the interaction of this organism with the cell types involved are necessary. this article summarizes the current knowledge on the interaction of c. pneumoniae with human endothelial cells. in vitro, c. pneumoniae can infect human endothelial cells and induce the expression of many molecules that are important mediators of ... | 2000 | 10839743 |
| chlamydial virulence determinants in atherogenesis: the role of chlamydial lipopolysaccharide and heat shock protein 60 in macrophage-lipoprotein interactions. | data from a spectrum of epidemiologic, pathologic, and animal model studies show that chlamydia pneumoniae infection is associated with coronary artery disease, but it is not clear how the organism may initiate or promote atherosclerosis. it is postulated that c. pneumoniae triggers key atherogenic events through specific virulence determinants. c. pneumoniae induces mononuclear phagocyte foam cell formation by chlamydial lipopolysaccharide (clps) and low-density lipoprotein oxidation by chlamyd ... | 2000 | 10839744 |
| collaborative multidisciplinary workshop report: interface of lipid metabolism, atherosclerosis, and chlamydia infection. | 2000 | 10839745 | |
| chlamydia, inflammation, and atherogenesis. | atherosclerotic lesions are initiated and progress largely as a result of a chronic, fibroproliferative, inflammatory response. this review discusses how chlamydia pneumoniae could conceivably contribute to this chronic inflammatory response and reports on recent in vivo and in vitro studies. in vivo studies in mice demonstrate that c. pneumoniae infection is disseminated to the artery wall following infection in the lung by alveolar macrophages. recent in vitro studies show that infected u937 c ... | 2000 | 10839746 |
| chlamydia pneumoniae-induced atherosclerosis in a rabbit model. | in order to establish a causative relationship between chlamydia pneumoniae and atherosclerosis, animal models have been proposed. in a rabbit model, arterial intimal thickening has been induced by direct intravascular and intranasal inoculation with c. pneumoniae. c. pneumoniae infection can induce significant acceleration of atherosclerosis in a mildly hyperlipidemic rabbit model but is prevented by treatment with azithromycin. together these preliminary rabbit experiments suggest that c. pneu ... | 2000 | 10839748 |
| mouse models of c. pneumoniae infection and atherosclerosis. | mouse models were used to determine whether chlamydia pneumoniae establishes chronic infection of the aorta and contributes to atherogenesis. persistent infection of the aorta occurred in 11 of 31 hyperlipidemic apolipoprotein e-deficient (apoe(-/-)) mice but not in c57bl/6j mice fed a normal diet after a single inoculation and in both models following repeated inoculation with c. pneumoniae. repeated inoculation of c57bl/6j mice resulted in inflammatory changes in the heart and aorta in 8 of 40 ... | 2000 | 10839749 |
| antibiotics effects in a rabbit model of chlamydia pneumoniae-induced atherosclerosis. | the association of chlamydia pneumoniae infection with the complications of atherosclerosis, cardiovascular disease, and stroke are well established. c. pneumoniae infection of new zealand white rabbit respiratory tract can result in early changes of atherosclerosis of the aorta that are not produced by sham infection or by mycoplasma pneumoniae (which result in similar lung pathology). early institution of antimicrobials with antichlamydial activity (azithromycin, clarithromycin, moxifloxacin, ... | 2000 | 10839750 |
| collaborative multidisciplinary workshop report: what questions regarding the role of chlamydia pneumoniae in atherosclerosis and cardiovascular disease need to be addressed utilizing animal models? | 2000 | 10839751 | |
| chlamydial genomics and vaccine antigen discovery. | vaccine development for chlamydia species has progressed on several research fronts, including knowledge of the components of the immune response required for immunity and resolution of infection as well as effective modes of delivery. the antigens required to elicit protective immune responses have not been identified. the full biologic potential for chlamydia trachomatis and chlamydia pneumoniae was exposed by the completion of the genome sequence for each organism. this knowledge will aid vac ... | 2000 | 10839752 |
| comparison of outer membrane protein genes omp and pmp in the whole genome sequences of chlamydia pneumoniae isolates from japan and the united states. | chlamydia pneumoniae is a widespread pathogen of the respiratory tract that is also associated with atherosclerosis. the whole genome sequence was determined for a japanese isolate, c. pneumoniae strain j138. the sequence predicted a variety of genes encoding outer membrane proteins (omps) including ompa and porb, another 10 predicted omp genes, and 27 pmp genes. all were detected in the whole genome sequence of strain cwl029, a strain isolated and sequenced in the united states. a comparative s ... | 2000 | 10839753 |
| potential relevance of chlamydia pneumoniae surface proteins to an effective vaccine. | the surface of chlamydia pneumoniae is covered with proteins but their exact identification is not known probably because of the presence of conformational epitopes. a family of 21 pmp genes has been found by dna sequencing. in common, these genes have the capacity to encode the amino acid motif ggai. several of the genes have the capacity to encode outer membrane proteins of about 100 kda. thus, they are candidate genes to encode the protein(s) present in the 98-kda protein band of the c. pneum ... | 2000 | 10839754 |
| the potential for vaccine development against chlamydial infection and disease. | chlamydia trachomatis and chlamydia pneumoniae appear to share a common immunobiology with about 80% of their protein coding genes being orthologs. progress in dna vaccine development for c. trachomatis suggests that such a subunit approach may prove useful for c. pneumoniae. the recent finding that it is possible to select for chlamydiae with targeted mutations in key metabolic genes together with the new knowledge of the chlamydia genome also suggests that it may be possible to develop live at ... | 2000 | 10839755 |
| use of a mouse lung challenge model to identify antigens protective against chlamydia pneumoniae lung infection. | chlamydia pneumoniae is emerging as a significant human pathogen. infection causes a range of respiratory tract diseases and is associated with atherosclerosis. a vaccine could provide a considerable public health benefit; however, antigens able to elicit a protective immune response are largely unknown. a panel of open-reading frames (orfs) from the c. pneumoniae genome sequence was screened for ability to elicit protective responses. balb/c mice immunized with dna containing the orfs were test ... | 2000 | 10839756 |
| collaborative multidisciplinary workshop report: progress toward a chlamydia pneumoniae vaccine. | 2000 | 10839757 | |
| antibiotics in the prevention and treatment of coronary heart disease. | seroepidemiology, pathology, and animal studies provide evidence for a possible association between chlamydia pneumoniae infections and atherosclerosis, coronary heart disease, and myocardial infarction. if this association exists, then exposure to certain antibiotics may positively affect the clinical course after an acute ischemic cardiac event (secondary prevention) and affect the risk of developing a first-time myocardial infarction (primary prevention). preliminary evidence from clinical tr ... | 2000 | 10839758 |
| past use of erythromycin, tetracycline, or doxycycline is not associated with risk of first myocardial infarction. | a population-based case-control study of patients enrolled at group health cooperative of puget sound was conducted to evaluate whether past use of antibiotics active against chlamydia pneumoniae is associated with a decrease in the risk of first myocardial infarction (mi). cases with incident fatal and nonfatal mi from mid-1986 through 1995 (n=1796) were compared with randomly sampled controls frequency-matched to cases for age, sex, and year (n=4882). use of erythromycin, tetracycline, or doxy ... | 2000 | 10839759 |
| inflammation, infection, or both in atherosclerosis: the roxis trial in perspective. | the role of infection in the instability of atherosclerotic plaques has been questioned because of discrepancies in the results of clinical trials that tested antibiotics in acute coronary syndromes. the results of the randomized trial of roxithromycin in non-q-wave coronary syndromes (roxis) are summarized and contrasted with two other pilot studies of antibiotic therapy of coronary artery disease. relevant characteristics of patients enrolled and rationales for these trials are discussed and s ... | 2000 | 10839760 |
| the academic study in perspective (azithromycin in coronary artery disease: elimination of myocardial infection with chlamydia). | chlamydia pneumoniae, a common cause of respiratory infection, is vasotropic and frequently found in human atheromas. whether it plays a causal role in coronary artery disease (cad) is uncertain. the effects of 3 months of azithromycin treatment or placebo were tested in 302 patients with chronic cad seropositive to c. pneumoniae at 3-6 months. azithromycin reduced a global rank sum score of 4 inflammatory markers (c-reactive protein [crp], interleukin [il]-1, il-6, tumor necrosis factor-alpha; ... | 2000 | 10839761 |
| rationale and design of a secondary prevention trial of antibiotic use in patients after myocardial infarction: the wizard (weekly intervention with zithromax [azithromycin] for atherosclerosis and its related disorders) trial. | mounting evidence supports the contention that atherosclerosis is an inflammatory disease. recently a possible role for infectious microorganisms has gathered attention. chlamydia pneumoniae is one possible pathogen. if c. pneumoniae is a target organism, antibiotics with antichlamydial activity may be able to ameliorate plaque instability. the wizard trial is a secondary prevention study that is assessing the impact of a 3-month course of azithromycin compared with placebo on the progression of ... | 2000 | 10839762 |
| description and status of the azithromycin and coronary events study (aces). | the azithromycin and coronary events study is a randomized, double-blind, placebo controlled trial of azithromycin among adults with stable coronary artery disease. the study is based on the hypothesis that infection with chlamydia pneumoniae may be causally associated with cardiovascular disease and therefore that treatment directed against this organism may reduce the risk of subsequent coronary events. participants randomized to treatment will receive 600 mg of azithromycin orally once a week ... | 2000 | 10839763 |
| collaborative multidisciplinary workshop report: clinical antimicrobial trials for primary and secondary prevention of atherosclerotic cardiovascular disease. | the task assigned to the working group on clinical antimicrobial trials for primary and/or secondary prevention of atherosclerotic cardiovascular disease was to evaluate the need for additional clinical antibiotic trials of a primary or secondary nature for the treatment of atherosclerotic heart disease and to suggest possible designs for future trials. in addition, the working group was to define the role of collaboration in answering research questions. | 2000 | 10839764 |
| what is needed to prove that chlamydia pneumoniae does, or does not, play an etiologic role in atherosclerosis? | 2000 | 10839765 | |
| relationship of chlamydia pneumoniae infection to severity of human coronary atherosclerosis. | infection with chlamydia pneumoniae has been postulated to play a pathogenic role in atherosclerosis. we examined the role of infection with c pneumoniae in relation to the extent of coronary atherosclerosis. | 2000 | 10840006 |
| chlamydia pneumonia (and other infective agents) in atherosclerosis and acute coronary syndromes. how good is the evidence? | 2000 | 10843822 | |
| bacterial infection and the pathogenesis of copd. | bacterial infection of the lower respiratory tract can impact on the etiology, pathogenesis, and the clinical course of copd in several ways. several recent cohort studies suggest that lung growth is impaired by childhood lower respiratory tract infection, making these individuals more vulnerable to developing copd on exposure to additional injurious agents. impairment of mucociliary clearance and local immune defense in smokers allows bacterial pathogens to gain a foothold in the lower respirat ... | 2000 | 10843957 |
| infectious etiology of acute exacerbations of chronic bronchitis. | infectious agents are a major cause of acute exacerbations of chronic bronchitis (aecb) and copd. several respiratory viruses are associated with 30% of exacerbations, with or without a superimposed bacterial infection. atypical bacteria, mostly chlamydia pneumoniae, have been implicated in < 10% of aecb. the role of bacterial pathogens when isolated from the respiratory tract during aecb has become better defined by application of several newer investigative techniques. bacterial pathogens can ... | 2000 | 10843981 |
| [new enemy for our hearts. what do we know today about the role of chlamydia?]. | 2000 | 10851865 | |
| [chlamydia pneumoniae infection in patients with acute bronchitis and bronchial asthma]. | in this study, a total of 60 patients with acute bronchitis, 71 patients with bronchial asthma and 20 healthy volunteers were serologically and bacteriologically analyzed to investigate whether chlamydia pneumoniae infection is associated with the onset and the exacerbation with acute bronchitis and bronchial asthma. antibody titers to chlamydia pneumoniae were also measured and compared by elisa method. the antibody-positive rate in the patients with acute bronchitis (88.4%) was significantly h ... | 2000 | 10853299 |
| microbiologic efficacy of moxifloxacin for the treatment of community-acquired pneumonia due to chlamydia pneumoniae. | nasopharyngeal specimens for culture of chlamydia pneumoniae were obtained from patients participating in two pneumonia treatment studies: an open study of 400 mg moxifloxacin orally, qds for 10 days and a randomized, double-blind comparison of moxifloxacin, 400 mg orally, qds versus clarithromycin, 500 mg orally, bd, both for 10 days. c. pneumoniae was eradicated from the nasopharynx of seven of ten (70%) microbiologically evaluable patients who were treated with moxifloxacin and four of four w ... | 2000 | 10854812 |
| frequency of coexistence of cytomegalovirus and chlamydia pneumoniae in atherosclerotic plaques. | cytomegalovirus (cmv) and chlamydia pneumoniae (c. pneumoniae) antigens and dna sequences have been demonstrated in atherosclerotic plaques by several investigators. most significantly, cmv dna was found both in atherosclerotic lesions as well as in uninvolved areas of aortas and carotid artery, whereas c. pneumoniae was mostly detected in advanced carotid atherosclerotic lesions. | 2000 | 10857040 |
| requirement for nf-kappab in transcriptional activation of monocyte chemotactic protein 1 by chlamydia pneumoniae in human endothelial cells. | infection with chlamydia pneumoniae, a causative agent of acute and chronic respiratory diseases, has recently been implicated as a potential risk factor in atherosclerosis. atherosclerotic lesions are characterized by monocyte infiltration, which may be regulated by the chemokine monocyte chemotactic protein 1 (mcp-1). we have previously shown that c. pneumoniae infection stimulates mcp-1 production in human endothelial cells, an event which may be specific to this species of chlamydia, since c ... | 2000 | 10858246 |
| in vitro pharmacodynamics of the new ketolides hmr 3004 and hmr 3647 (telithromycin) against chlamydia pneumoniae. | the ketolides hmr 3004 and hmr 3647 (telithromycin) are a new class of macrolides that have a potential clinical efficacy against intracellular pathogens. the objectives of this study were to investigate the mic, minimum bactericidal concentration, and time-dependent killing of two chlamydia pneumoniae strains of the two ketolides. the killing effect was also studied with a newly developed intracellular in vitro kinetic model. furthermore, hmr 3647 was studied for the effect of a subinhibitory c ... | 2000 | 10858341 |
| chlamydia pneumoniae and chronic obstructive pulmonary disease: bronchial biopsies (pcr and culture) and specific serum antibodies in patients and controls. | 2000 | 10864412 | |
| the role of adaptive immunity in atherosclerosis. | atherosclerosis is an inflammatory disease induced by a lipid metabolic disturbance at sites of hemodynamic strain in the vasculature. studies in both man and experimental animal models show an involvement of innate and adaptive immune mechanisms in the disease process. our recent studies in apoe-knockout mice show that the level of hypercholesterolemia affects the functional properties of the immune response. modulating immune activity by injections of polyclonal immunoglobulins inhibits diseas ... | 2000 | 10865825 |
| susceptibility to multiple sclerosis: interplay between genes and environment. | multiple sclerosis is a complex trait of unknown etiology. epidemiological data have shown that susceptibility to multiple sclerosis is determined by both genetic and environmental factors. it is unknown whether the clinical subcategories of multiple sclerosis are separate diseases with separate etiologies and causes. recent theories of the pathogenesis of multiple sclerosis and candidate genes are discussed. other potential nonchromosomal factors involved in multiple sclerosis susceptibility su ... | 2000 | 10871246 |
| comparison of whole genome sequences of chlamydia pneumoniae j138 from japan and cwl029 from usa. | chlamydia pneumoniae is a widespread pathogen of humans causing pneumonia and bronchitis. there are many reports of an association between c.pneumoniae: infection and atherosclerosis. we determined the whole genome sequence of c.pneumoniae: strain j138 isolated in japan in 1994 and compared it with the sequence of strain cwl029 isolated in the usa before 1987. the j138 circular chromosome consists of 1 226 565 nt (40.7% g+c) with 1072 likely protein-coding genes that is 3665 nt shorter than the ... | 2000 | 10871362 |
| respiratory infection and coronary heart disease: progression of a paradigm. | we have developed a previously published paradigm concerning causation of coronary heart disease, based on the probability that the fundamental cause is a microbe, probably chlamydia pneumoniae, and that the progress of the disease is influenced by number of accelerating and inhibiting factors. we propose that cigarette smoking acts via respiratory infection, this itself being influenced by immunocompetence resulting from sunlight exposure. we also propose an immuno-enhancing effect of oestrogen ... | 2000 | 10873188 |
| chlamydia pneumoniae present in the human synovium are viable and metabolically active. | we demonstrated that chromosomal dna from chlamydia pneumoniae is present in synovial tissue in at least some patients with reactive arthritis/reiter's syndrome and other arthritides. here, we provide initial molecular evidence that the bacterium is viable and metabolically active when present in the synovium. we used reverse transcription-polymerase chain reaction (rt-pcr) assays targeting primary transcripts from the chlamydial rrna operons, and mrna from several c. pneumoniae genes (hsp60, om ... | 2000 | 10873487 |
| detection of viable chlamydia pneumoniae in abdominal aortic aneurysms. | to investigate the presence of chlamydia pneumoniae in the wall of abdominal aortic aneurysms (aaas) and in the aortas of patients without a history of cardiovascular disease. | 2000 | 10873732 |
| failure to detect chlamydia pneumoniae in the late-onset alzheimer's brain. | epidemiological studies have yet to identify a single cause for the most common late-onset form of alzheimer's disease. the common respiratory pathogen chlamydia pneumoniae recently has been implicated as a risk factor for this form of alzheimer's disease. were this true, there would be a dramatic shift in current paradigms of alzheimer's disease research and treatment. in the absence of published confirmation, we obtained postmortem brain tissue from late-onset alzheimer's disease patients (n = ... | 2000 | 10878049 |
| analytical sensitivity, reproducibility of results, and clinical performance of five pcr assays for detecting chlamydia pneumoniae dna in peripheral blood mononuclear cells. | chlamydia pneumoniae has been associated with atherosclerosis and coronary artery disease (cad), and its dna has been detected in atheromatous lesions of the aorta, carotid, and coronary arteries by a variety of pcr assays. the objective of this study was to compare the performances of five published pcr assays in the detection of c. pneumoniae in peripheral blood mononuclear cells (pbmcs) from patients with coronary artery disease. the assays included two conventional pcrs, one targeting a clon ... | 2000 | 10878053 |
| microvirus of chlamydia psittaci strain guinea pig inclusion conjunctivitis: isolation and molecular characterization. | the authors report the isolation and molecular characterization of a bacteriophage, φcpg1, which infects chlamydia: psittaci strain guinea pig inclusion conjunctivitis. purified virion preparations contained isometric particles of 25 nm diameter, superficially similar to spike-less members of the φx174 family of bacteriophages. the single-stranded circular dna genome of φcpg1 included five large orfs, which were similar to orfs in the genome of a previously described chlamydia: bacte ... | 2000 | 10878129 |
| the relation between chlamydia pneumoniae infection and abdominal aortic aneurysm: case-control study. | due to recent interest in the role of chlamydia pneumoniae as a pathogen of the vascular system, a case-control study was conducted to investigate the association between serological evidence of infection with c. pneumoniae and the occurrence of abdominal aortic aneurysm. detectable igg antibody to c. pneumoniae was more common among abdominal aortic aneurysm cases than among control patients (adjusted odds ratio, 5.97; p = .08), as was detectable igm antibody (10% vs. 0%; p = .02). these findin ... | 2000 | 10880309 |
| hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents. | low-molecular-weight beta-sulfonyl- and beta-sulfinylhydroxamic acid derivatives have been synthesized and found to be potent inhibitors of escherichia coli peptide deformylase (pdf). most of the compounds synthesized and tested displayed antibacterial activities that cover several pathogens found in respiratory tract infections, including chlamydia pneumoniae, mycoplasma pneumoniae, haemophilus influenzae, and moraxella catarrhalis. the potential of these compounds as antibacterial agents is di ... | 2000 | 10882358 |
| silicone gel implant capsules and chlamydia antigens. | 2000 | 10883647 | |
| chlamydia pneumoniae and the risk of first ischemic stroke : the northern manhattan stroke study. | serological evidence of infection with chlamydia pneumoniae has been associated with cardiovascular disease in multiple epidemiological studies. the data on its association with ischemic stroke are limited. we sought to determine whether chronic c pneumoniae infection is associated with ischemic stroke in a multi-ethnic population. | 2000 | 10884447 |
| chlamydia pneumoniae seropositivity is associated with carotid artery intima-media thickness. | infection may both augment the atherosclerotic process and contribute to later manifestations of overt clinical disease. chlamydia pneumoniae elementary bodies have been detected in atherosclerotic lesions. the aim of the present study was to investigate whether elevated titers of antibodies and circulating immune complexes to c pneumoniae were associated with ultrasound findings indicating presence of atherosclerosis in the carotid artery. | 2000 | 10884448 |
| infectious agents in coronary atherosclerosis. | 1999 | 10887367 | |
| demonstration of an association between chlamydia pneumoniae infection and venous thromboembolic disease. | chlamydia pneumoniae infection has been linked to atherosclerosis, but a possible relationship with venous thromboembolism (vte) has not been sought. we determined circulating anti-c. pneumoniae antibody levels in patients with vte. we studied 176 case patients with objectively diagnosed vte and 197 age- and sex-matched healthy controls, in a retrospective study. acquired risk factors for vte and frequent predisposing genetic factors (factor v arg 506 gln and factor ii g 20210 a mutations) were ... | 2000 | 10896243 |
| chlamydia pneumoniae and heart. | 2000 | 10897250 | |
| epidemiological investigation of nine respiratory pathogens in hospitalized children in germany using multiplex reverse-transcriptase polymerase chain reaction. | the aim of this study was to generate urgently needed data on respiratory pathogens in german children using an economical and efficient tool. nasopharyngeal aspirates of hospitalized children 0-16 years of age with an acute respiratory tract infection were tested by a nine-valent multiplex reverse-transcriptase polymerase chain reaction. of 1281 children, 449 (35%) had an acute respiratory tract infection caused by at least one of the organisms studied; there were 29 cases of dual infection. at ... | 2000 | 10898133 |
| chlamydia pneumoniae induces inflammatory changes in the heart and aorta of normocholesterolemic c57bl/6j mice. | chlamydia pneumoniae infection induces inflammatory changes in blood vessels in normocholesterolemic rabbits, but it is not known whether the same phenomenon occurs in other animal models. thus, in this study, c57bl/6j mice were inoculated with c. pneumoniae. inflammatory changes in the heart or aorta were observed in a small number of chronically infected mice. no evidence of atherosclerotic lesions was found in any of the mice. these findings suggest that chronic c. pneumoniae infection can in ... | 2000 | 10899884 |
| role of nramp1 deletion in chlamydia infection in mice. | elicited macrophages from 129sv mice with a functional deletion of the natural-resistance-associated macrophage protein 1 gene (nramp1) were shown to be as susceptible as wild-type mice to infection with the chlamydia trachomatis mouse pneumonitis and l3 serovars and to chlamydia pneumoniae. furthermore, the two groups of mice were shown to be similarly susceptible to an intranasal infection with these microorganisms. in conclusion, the nramp1 gene does not appear to play a major role in the reg ... | 2000 | 10899900 |
| atherosclerosis: an infectious disease? | traditional risk factors do not fully account for atherogenesis. there is increasing evidence that infectious pathogens, such as helicobacter pylori, cytomegalovirus, and chlamydia pneumoniae, may promote the atherosclerotic cascade. proposed mechanisms include macrophage transformation, endothelial injury, chronic inflammation, and thrombosis. specific antibiotic therapy may affect outcome. | 1999 | 10901762 |
| detection of chlamydia pneumoniae in giant cell vasculitis and correlation with the topographic arrangement of tissue-infiltrating dendritic cells. | recent studies suggest that giant cell arteritis (gca) may be an antigen-driven disease. since chlamydia pneumoniae has been identified in arterial vessel walls, it was hypothesized that this organism might be associated with gca. | 2000 | 10902759 |
| heart disease and the inflammatory response. | 2000 | 10903629 | |
| low grade inflammation and coronary heart disease: prospective study and updated meta-analyses. | to assess associations between baseline values of four different circulating markers of inflammation and future risk of coronary heart disease, potential triggers of systemic inflammation (such as persistent infection), and other markers of inflammation. | 2000 | 10903648 |
| chlamydia pneumoniae infection and mortality from ischaemic heart disease: large prospective study. | to determine whether there is an independent association between infection with chlamydia pneumoniae and ischaemic heart disease. | 2000 | 10903649 |
| chlamydia pneumoniae igg titres and coronary heart disease: prospective study and meta-analysis. | to examine the association between coronary heart disease and serum markers of chronic chlamydia pneumoniae infection. | 2000 | 10903653 |
| chlamydia pneumoniae and atherosclerosis. identification of bacterial dna in the arterial wall. | the intracellular gram-negative bacterium chlamydia pneumoniae has been associated with atherosclerosis. the presence of chlamydia pneumoniae has been investigated in fragments of the arterial wall with a technique for dna identification. | 2000 | 10904285 |
| great amount of c.pneumoniae in ruptured plaque vessel segments at autopsy. a comparative study with stable plaques. | a possible relationship between c.pneumoniae (cp) infection, atherosclerosis and acute myocardial infarction is a debated matter. now we performed the search of cp in histological segments of fatal ruptured plaques and of stable plaques by histochemistry (macchiavello stain), immunohistochemistry and in situ hybridization techniques. electron microscopy and confocal laser microscopy techniques were used in two additional cases. the semi-quantification of cp + cells (0-4+) and quantification of l ... | 2000 | 10904288 |
| detection of viral and bacterial protein in endomyocardial biopsies of patients with inflammatory heart muscle disease? | the development of highly sensitive molecular biological methods such as in-situ hybridization and polymerase chain reaction (pcr) made it possible to detect viral/bacterial nucleic acid in human endomyocardial biopsies. however, only a few investigations addressed the problem of latent persistence of viral and bacterial genome and the detection of the corresponding proteins, which could have important consequences for the clinical course of the disease. the purpose of this study was to determin ... | 2000 | 10904844 |
| chlamydia pneumoniae igg seropositivity and risk of deep-vein thrombosis. | in a population-based case-control study of 474 patients with a first episode of deep-vein thrombosis and 474 age-matched and sex-matched controls, we found no effect of chlamydia pneumoniae infection on the occurrence of deep-vein thrombosis. | 2000 | 10905248 |
| autoimmunity in atherosclerosis. the role of autoantigens. | 2000 | 10907109 | |
| the role of bacterial infections in asthma. | in summary, bacterial organisms are clinically relevant contributors to asthma exacerbations, and have received much less attention than viruses in this process. streptococcus pneumoniae, hemophilus influenzae, and moraxella catarrhalis have been linked to asthma exacerbations, particularly when sinusitis is present. treatment therefore should be directed toward these organisms if a bacterial cause is suspected. the atypical bacteria--specifically, c. pneumoniae and m. pneumoniae--deserve specia ... | 2000 | 10907590 |
| ubiquitous pathogens: links between infection and autoimmunity in ms? | 2000 | 10908883 | |
| [is atherosclerosis an infectious disease]. | 2000 | 10909147 | |
| frequency of serological evidence of bordetella infections and mixed infections with other respiratory pathogens in university students with cough illnesses. | banked acute-phase and convalescent-phase serum samples from a previous study of respiratory illness in university students were examined for significant (>/=2-fold) increases in elisa titers of iga and igg antibody to bordetella pertussis filamentous hemagglutinin, pertactin, and fimbriae-2 and >/=4-fold titer increases to agglutinogens by agglutination. elisa titers of antibody to pertussis toxin could not be determined because of technical problems. chlamydia pneumoniae infections were diagno ... | 2000 | 10913388 |
| severe chlamydia pneumoniae infection in patients with neutropenia: case reports and literature review. | three cases of life-threatening c. pneumoniae infection in patients with acute leukemia and treatment-induced neutropenia are described. diagnosis was made on the basis of the detection of c. pneumoniae-dna, complemented by serology. the role of the widely distributed respiratory tract pathogen c. pneumoniae in febrile neutropenia is poorly understood, and studies are needed to estimate the frequency of severe pulmonary infection caused by this agent in patients with neutropenia. | 2000 | 10913419 |
| diagnosis of chlamydia pneumoniae in community-acquired pneumonia in children in chile. | the incidence of chlamydia pneumoniae in community-acquired pneumonia in children was studied prospectively in 112 children aged 1 mo to 14 y. diagnosis of c. pneumoniae was performed by polymerase chain reaction (pcr) on nasopharyngeal aspirates and serology by the microimmunofluorescence test on a single serum specimen. three (2.7%) cases of pneumonia due to this agent were diagnosed by both pcr and serology. c. pneumoniae was not found in any of 62 children below 5 y of age. in the age group ... | 2000 | 10914956 |
| [the value of bronchoalveolar lavage in the clarifying of hiv-associated lung diseases]. | examination of sputum is the first diagnostic step in the evaluation of hiv-infected patients with pulmonary complications. we were interested in the indications and the diagnostic value of subsequent bronchoscopy and bronchoalveolar lavage (bal) and especially the importance of so-called atypical bacteria. | 2000 | 10916494 |
| does infection have a role in the pathogenesis of coronary artery disease? | 2000 | 10917081 | |
| respiratory infections and asthma. | clinical and experimental evidence suggests an important role for respiratory infections in the development of asthma attacks. viral upper respiratory infections have been associated with 80% of asthma exacerbations in children and 50% of all asthma episodes in adults. human rhinovirus has been implicated as the principal virus associated with asthma episodes. separate studies indicate that atypical bacteria such as chlamydia pneumoniae and mycoplasma pneumoniae may precipitate asthma symptoms. ... | 2000 | 10919505 |
| infections, atherosclerosis, and coronary heart disease. | there is growing evidence that the immune response is involved in atherosclerosis. studies done over the past several years have shown an association between markers of inflammation and coronary atherosclerosis with an exacerbation of the inflammatory process during acute myocardial ischemia. overall, these data have greatly renewed interest in the infectious theory of atherosclerosis and coronary heart disease. search of bibliographic databases (from january 1991 through december 1999) and manu ... | 2000 | 10920505 |
| the naval health research center respiratory disease laboratory. | concern about emerging and reemerging respiratory pathogens prompted the development of a respiratory disease reference laboratory at the naval health research center. professionals working in this laboratory have instituted population-based surveillance for pathogens that affect military trainees and responded to threats of increased respiratory disease among high-risk military groups. capabilities of this laboratory that are unique within the department of defense include adenovirus testing by ... | 2000 | 10920635 |
| emerging relations between infectious diseases and coronary artery disease and atherosclerosis. | cardiovascular disease is the leading cause of death in developed countries. the cause is multifactorial. a substantial proportion of patients with coronary artery disease (cad) do not have traditional risk factors. infectious diseases may play a role in these cases, or they may intensify the effect of other risk factors. the association of cad and chlamydia pneumoniae infection is firmly established, but causality is yet to be proven. the link with other infectious agents or conditions, such as ... | 2000 | 10920732 |
| treatment of chlamydia pneumoniae. | 2000 | 10926449 | |
| t lymphocyte lines isolated from atheromatous plaque contain cells capable of responding to chlamydia antigens. | chlamydia pneumoniae infection is associated with atherosclerosis and the organism has been identified in arterial lesions. to determine whether t lymphocyte-mediated immune responses to chlamydia antigens within plaque could contribute to pathogenesis, we have derived t cell lines from atherosclerotic plaques of 32 patients. culture with il-2 alone proved insufficient for cellular activation and expansion, but additional stimulation with phytohaemagglutinin (pha) or recall antigens allowed cons ... | 2000 | 10931140 |
| chlamydia pneumoniae antibodies and adult-onset asthma. | 2000 | 10932089 | |
| [diagnostic procedures in chlamydia pneumoniae infections]. | 2000 | 10932409 | |
| chlamydia pneumoniae infection in adults with chronic cough compared with healthy blood donors. | in a small uncontrolled study, persistent cough has recently been found to be associated with serological evidence of acute chlamydia pneumoniae infection. in order to assess whether c. pneumoniae plays a role in chronic cough, the prevalence of c. pneumoniae infection in 201 adult patients with chronic cough was compared with the prevalence in 106 healthy blood donors without respiratory tract symptoms in the preceding 3 months. a microimmunofluorescence antibody test was used to determine c. p ... | 2000 | 10933094 |
| coronary heart disease and chlamydia pneumoniae dna in blood mononuclear cells. | 2000 | 10933387 | |
| serological analysis of specific iga to chlamydia pneumoniae: increased sensitivity of iga antibody detection using prolonged incubation and high antigen concentration. | the microimmunofluorescence technique (mif) is recognized as the only test hitherto allowing discrimination between different chlamydia species and is considered to be the reference method for serology. this method was developed for the detection of igg and igm antibodies only. we investigated the effects of some test parameters on the ability of mif to detect chlamydia pneumoniae iga. these parameters were the time needed for binding of serum iga to c. pneumoniae antigen and the effect of antig ... | 2000 | 10937773 |