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screening of selected medicinal plants for in vitro antidermatophytic activity.different solvent extracts of leaves of achyranthes aspera, aegle marmelos, cleistanthus collinus, curcuma aromatica and strychnos nux-vomica were screened against dermatophytes viz., trichophyton mentagrophytes, t. rubrum, microsporum gypseum, m. canis and epidermophyton floccossum var. nigricans. the mean zones of inhibition were between 7.1 and 26.5mm. minimum inhibitory concentrations (mic) and minimum fungicidal concentrations (mfc) were from 7.81 to 500 and from 15.62 to 1000μg/ml respecti ...201324135649
in vitro susceptibility of dermatomycoses agents to six antifungal drugs and evaluation by fractional inhibitory concentration index of combined effects of amorolfine and itraconazole in dermatophytes.to investigate the antifungal drug susceptibility of fungi responsible for dermatomycoses, minimum inhibition concentration (mic) tests were performed in 44 strains of dermatophytes, including trichophyton rubrum, trichophyton mentagrophytes, trichophyton verrucosum, trichophyton tonsurans, microsporum canis, microsporum gypseum and epidermophyton floccosum, with six antifungal drugs (amorolfine, terbinafine, butenafine, ketoconazole, itraconazole and bifonazole) by broth microdilution assay acc ...201424215461
in vitro susceptibility of dermatomycoses agents to six antifungal drugs and evaluation by fractional inhibitory concentration index of combined effects of amorolfine and itraconazole in dermatophytes.to investigate the antifungal drug susceptibility of fungi responsible for dermatomycoses, minimum inhibition concentration (mic) tests were performed in 44 strains of dermatophytes, including trichophyton rubrum, trichophyton mentagrophytes, trichophyton verrucosum, trichophyton tonsurans, microsporum canis, microsporum gypseum and epidermophyton floccosum, with six antifungal drugs (amorolfine, terbinafine, butenafine, ketoconazole, itraconazole and bifonazole) by broth microdilution assay acc ...201424215461
rapid detection for rabbit-derived dermatophytes using microsatellite-primed polymerase chain reaction.a method exhibiting high sensitivity, specificity and rapidity to detect pathogenic dermatophytes was developed using microsatellite-primed polymerase chain reaction (pcr) in combination with a clustering method. the dna fragments of trichophyton mentagrophyton, microsporum gypseum and microsporum canis were amplified by using the primer (gaca)4 to detect the dna polymorphism fingerprints. twenty-one clinical strains identified as t. mentagrophyton, m. gypseum or m. canis by morphological method ...201424296862
rapid detection for rabbit-derived dermatophytes using microsatellite-primed polymerase chain reaction.a method exhibiting high sensitivity, specificity and rapidity to detect pathogenic dermatophytes was developed using microsatellite-primed polymerase chain reaction (pcr) in combination with a clustering method. the dna fragments of trichophyton mentagrophyton, microsporum gypseum and microsporum canis were amplified by using the primer (gaca)4 to detect the dna polymorphism fingerprints. twenty-one clinical strains identified as t. mentagrophyton, m. gypseum or m. canis by morphological method ...201424296862
pharmacological management of pediatric kerion celsi.we report a case of severe tinea capitis, treated successfully with griseofulvin. in our opinion, the treatment of this severe dermatophytosis with griseofulvin is safe and effective. other treatments, such as itraconazole pulsed therapy, failed, despite an initial improvement, leading to an aggressive recurrence of the lesion. we chose griseofulvin for its well-known large spectrum activity, also against uncommon species, like microsporum gypseum, which are responsible for the most severe cases ...201724355234
pharmacological management of pediatric kerion celsi.we report a case of severe tinea capitis, treated successfully with griseofulvin. in our opinion, the treatment of this severe dermatophytosis with griseofulvin is safe and effective. other treatments, such as itraconazole pulsed therapy, failed, despite an initial improvement, leading to an aggressive recurrence of the lesion. we chose griseofulvin for its well-known large spectrum activity, also against uncommon species, like microsporum gypseum, which are responsible for the most severe cases ...201724355234
restriction analysis of β-tubulin gene for differentiation of the common pathogenic dermatophytes.identification of dermatophytes at the species level, relying on macro- and microscopic properties of the colonies is time-consuming, questioned in many circumstances, and requires considerable expertise. in this study, we examined the potency of a new genetic marker, β-tubulin (bt2) gene, for differentiation of dermatophytes in an in silico and experimental restriction fragment length polymorphism (rflp) profile.201424395510
restriction analysis of β-tubulin gene for differentiation of the common pathogenic dermatophytes.identification of dermatophytes at the species level, relying on macro- and microscopic properties of the colonies is time-consuming, questioned in many circumstances, and requires considerable expertise. in this study, we examined the potency of a new genetic marker, β-tubulin (bt2) gene, for differentiation of dermatophytes in an in silico and experimental restriction fragment length polymorphism (rflp) profile.201424395510
successful use of silver impregnated hydrofiber dressing in the treatment of kerion celsi caused by microsporum gypseum.a method of treatment of tinea capitis is presented in a case of a 10-year-old boy who was referred to the pediatric surgical unit for the treatment of a skin lesion on the scalp, which had persisted for more than two months. the initial dermatologic examination led to the clinical diagnosis of inflammation of the scalp, while mycological analysis revealed an uncommon dermatophyte agent, microsporum gypseum, in the culture. the lesion was subsequently treated with local and oral antifungal agent ...201324476613
successful use of silver impregnated hydrofiber dressing in the treatment of kerion celsi caused by microsporum gypseum.a method of treatment of tinea capitis is presented in a case of a 10-year-old boy who was referred to the pediatric surgical unit for the treatment of a skin lesion on the scalp, which had persisted for more than two months. the initial dermatologic examination led to the clinical diagnosis of inflammation of the scalp, while mycological analysis revealed an uncommon dermatophyte agent, microsporum gypseum, in the culture. the lesion was subsequently treated with local and oral antifungal agent ...201324476613
trichophyton verrucosum infection in cattle farms of umbria (central italy) and transmission to humans.trichophyton verrucosum is the most common ringworm agent in cattle. epidemiology of cattle dermatophytoses in central italy is not clear. its diffusion among cattle and herdsmen was investigated in 20 umbrian farms, central italy. hairs and scales were taken from 395 animals and 31 workers. typical ringworm was present in 71.7% of cattle under 6 months and in 11% of animals over 6 months. t. verrucosum was isolated from 98.9% of symptomatic heads and was the most prevalent dermatophyte in all h ...201424621382
trichophyton verrucosum infection in cattle farms of umbria (central italy) and transmission to humans.trichophyton verrucosum is the most common ringworm agent in cattle. epidemiology of cattle dermatophytoses in central italy is not clear. its diffusion among cattle and herdsmen was investigated in 20 umbrian farms, central italy. hairs and scales were taken from 395 animals and 31 workers. typical ringworm was present in 71.7% of cattle under 6 months and in 11% of animals over 6 months. t. verrucosum was isolated from 98.9% of symptomatic heads and was the most prevalent dermatophyte in all h ...201424621382
kerion due to microsporum gypseum in a 1-month-old infant.microsporum gypseum is a rare cause of kerion in infancy. light microscopy, fluorescent microscopy and fungal culture of the infected hair aids in early and correct diagnosis. griseofulvin is the drug of choice for ectothrix fungi. we report a case of neonatal kerion caused by m. gypseum occurring at the age of 1 month, successfully treated with griseofulvin.201324778536
kerion due to microsporum gypseum in a 1-month-old infant.microsporum gypseum is a rare cause of kerion in infancy. light microscopy, fluorescent microscopy and fungal culture of the infected hair aids in early and correct diagnosis. griseofulvin is the drug of choice for ectothrix fungi. we report a case of neonatal kerion caused by m. gypseum occurring at the age of 1 month, successfully treated with griseofulvin.201324778536
a preliminary study on the occurrence of keratinophilic fungi in soils of jamaica.this report represents the first study of keratinophilic fungi present in soils of jamaica. out of the 40 soil samples examined from different habitats, 30 (75%) were positive for the presence of keratinophilic fungi, yielding 36 isolates of keratinophilic fungi. microsporum gypseum complex (represented by 16 isolates of m. gypseum, and four of m. fulvum) was most frequent, being present in 50% of the samples. a very high occurrence of this dermatophyte in jamaican soil is of public health signi ...201724879002
a preliminary study on the occurrence of keratinophilic fungi in soils of jamaica.this report represents the first study of keratinophilic fungi present in soils of jamaica. out of the 40 soil samples examined from different habitats, 30 (75%) were positive for the presence of keratinophilic fungi, yielding 36 isolates of keratinophilic fungi. microsporum gypseum complex (represented by 16 isolates of m. gypseum, and four of m. fulvum) was most frequent, being present in 50% of the samples. a very high occurrence of this dermatophyte in jamaican soil is of public health signi ...201724879002
mycological pattern of dermatophytosis in and around shimla hills.dermatophytosis is defined as the fungal infection of the skin, hair and nails by a group of keratinophillic fungi known as dermatophytes.201424891658
mycological pattern of dermatophytosis in and around shimla hills.dermatophytosis is defined as the fungal infection of the skin, hair and nails by a group of keratinophillic fungi known as dermatophytes.201424891658
balticidins a-d, antifungal hassallidin-like lipopeptides from the baltic sea cyanobacterium anabaena cylindrica bio33.balticidins a-d (1-4), four new antifungal lipopeptides, were isolated from the laboratory-cultivated cyanobacterium anabaena cylindrica strain bio33 isolated from a water sample collected from the baltic sea, rügen island, germany. fractionation of the 50% aqueous meoh extract was performed by bioassay-guided silica gel column chromatography followed by spe and repeated reversed-phase hplc. the main fraction containing the compounds exhibited a strong and specific antifungal activity with inhib ...201424937366
balticidins a-d, antifungal hassallidin-like lipopeptides from the baltic sea cyanobacterium anabaena cylindrica bio33.balticidins a-d (1-4), four new antifungal lipopeptides, were isolated from the laboratory-cultivated cyanobacterium anabaena cylindrica strain bio33 isolated from a water sample collected from the baltic sea, rügen island, germany. fractionation of the 50% aqueous meoh extract was performed by bioassay-guided silica gel column chromatography followed by spe and repeated reversed-phase hplc. the main fraction containing the compounds exhibited a strong and specific antifungal activity with inhib ...201424937366
two cases of dermatophytosis caused by microsporum gypseum and isolation of microsporum gypseum from soil in chigasaki city.we report two cases of dermatophytosis caused by microsporum (m.) gypseum. one case was a 59-year-old healthy woman who complained of itchy annular erythema on her right forearm. we isolated m. gypseum from scales on the forearm. the other case was a 73-year-old midwife who had developed infiltrated erythema on her face for 6 months. m. gypseum was isolated from scales of the nose. both women liked gardening and m. gypseum was isolated from the garden soil of these women by a hair-baiting techni ...201424943212
two cases of dermatophytosis caused by microsporum gypseum and isolation of microsporum gypseum from soil in chigasaki city.we report two cases of dermatophytosis caused by microsporum (m.) gypseum. one case was a 59-year-old healthy woman who complained of itchy annular erythema on her right forearm. we isolated m. gypseum from scales on the forearm. the other case was a 73-year-old midwife who had developed infiltrated erythema on her face for 6 months. m. gypseum was isolated from scales of the nose. both women liked gardening and m. gypseum was isolated from the garden soil of these women by a hair-baiting techni ...201424943212
antifungal, antileishmanial, and cytotoxicity activities of various extracts of berberis vulgaris (berberidaceae) and its active principle berberine.in this study, in vitro antidermatophytic activity against trichophyton mentagrophytes, trichophyton rubrum, microsporum canis, and microsporum gypseum was studied by disk diffusion test and assessment of minimum inhibitory concentration (mic) using clsi broth macrodilution method (m38-a2). moreover, antileishmanial and cytotoxicity activity of b. vulgaris and berberine against promastigotes of leishmania major and leishmania tropica were evaluated by colorimetric mtt assay. the findings indicat ...201424977052
antifungal, antileishmanial, and cytotoxicity activities of various extracts of berberis vulgaris (berberidaceae) and its active principle berberine.in this study, in vitro antidermatophytic activity against trichophyton mentagrophytes, trichophyton rubrum, microsporum canis, and microsporum gypseum was studied by disk diffusion test and assessment of minimum inhibitory concentration (mic) using clsi broth macrodilution method (m38-a2). moreover, antileishmanial and cytotoxicity activity of b. vulgaris and berberine against promastigotes of leishmania major and leishmania tropica were evaluated by colorimetric mtt assay. the findings indicat ...201424977052
synthesis and antimicrobial activity of novel 5-aminoimidazole-4-carboxamidrazones.a mild and simple method was developed to prepare a series of fifteen 5-aminoimidazole 4-carboxamidrazones, starting from the easily accessible 5-amino-4-cyanoformimidoyl imidazoles. the antimicrobial activity of these novel amidrazones was screened against gram positive (staphylococcus aureus) and gram negative (escherichia coli, pseudomonas aeruginosa) bacteria and candida sp. (candida albicans, candida krusei, candida parapsilosis). only a subset of compounds displayed fair-moderate activity ...201425193230
synthesis and antimicrobial activity of novel 5-aminoimidazole-4-carboxamidrazones.a mild and simple method was developed to prepare a series of fifteen 5-aminoimidazole 4-carboxamidrazones, starting from the easily accessible 5-amino-4-cyanoformimidoyl imidazoles. the antimicrobial activity of these novel amidrazones was screened against gram positive (staphylococcus aureus) and gram negative (escherichia coli, pseudomonas aeruginosa) bacteria and candida sp. (candida albicans, candida krusei, candida parapsilosis). only a subset of compounds displayed fair-moderate activity ...201425193230
in vitro antifungal activity and mechanism of essential oil from fennel (foeniculum vulgare l.) on dermatophyte species.fennel seed essential oil (fseo) is a plant-derived natural therapeutic against dermatophytes. in this study, the antifungal effects of fseo were investigated from varied aspects, such as mic and minimum fungicidal concentration, mycelia growth, spore germination and biomass. the results indicated that fseo had potent antifungal activities on trichophyton rubrum atcc 40051, trichophyton tonsurans 10-0400, microsporum gypseum 44693-1 and trichophyton mentagrophytes 10-0060, which is better than t ...201525351709
in vitro antifungal activity and mechanism of essential oil from fennel (foeniculum vulgare l.) on dermatophyte species.fennel seed essential oil (fseo) is a plant-derived natural therapeutic against dermatophytes. in this study, the antifungal effects of fseo were investigated from varied aspects, such as mic and minimum fungicidal concentration, mycelia growth, spore germination and biomass. the results indicated that fseo had potent antifungal activities on trichophyton rubrum atcc 40051, trichophyton tonsurans 10-0400, microsporum gypseum 44693-1 and trichophyton mentagrophytes 10-0060, which is better than t ...201525351709
cutaneous bacterial species from lithobates catesbeianus can inhibit pathogenic dermatophytes.antibiotics are being successfully used to fight many infectious diseases caused by pathogenic microorganisms. however, new infectious diseases are continuously being identified, and some known pathogens are becoming resistant against known antibiotics. furthermore, many antifungals are causing serious side effects in long-term treatments of patients, and many skin infections caused by dermatophytes are difficult to cure. the beneficial roles of resident cutaneous microbiota to inhibit pathogeni ...201525431089
cutaneous bacterial species from lithobates catesbeianus can inhibit pathogenic dermatophytes.antibiotics are being successfully used to fight many infectious diseases caused by pathogenic microorganisms. however, new infectious diseases are continuously being identified, and some known pathogens are becoming resistant against known antibiotics. furthermore, many antifungals are causing serious side effects in long-term treatments of patients, and many skin infections caused by dermatophytes are difficult to cure. the beneficial roles of resident cutaneous microbiota to inhibit pathogeni ...201525431089
evaluation of antifungal activities of the essential oil and various extracts of nigella sativa and its main component, thymoquinone against pathogenic dermatophyte strains.plant extracts and plant-derived compounds are valuable sources as folk medicine for the treatment and prevention of a wide range of diseases including infectious diseases. in the present study, the antifungal activities of the essential oil and various extracts nigella sativa and its active principle, thymoquinone against trichophyton mentagrophytes, microsporum canis and microsporum gypseum as pathogenic dermatophyte strains have been evaluated. in addition, the cytotoxic effects of n. sativa ...201425442918
evaluation of antifungal activities of the essential oil and various extracts of nigella sativa and its main component, thymoquinone against pathogenic dermatophyte strains.plant extracts and plant-derived compounds are valuable sources as folk medicine for the treatment and prevention of a wide range of diseases including infectious diseases. in the present study, the antifungal activities of the essential oil and various extracts nigella sativa and its active principle, thymoquinone against trichophyton mentagrophytes, microsporum canis and microsporum gypseum as pathogenic dermatophyte strains have been evaluated. in addition, the cytotoxic effects of n. sativa ...201425442918
isolation of keratinophilic fungi from selected soils of sanjay gandhi national park, mumbai (india).one hundred and twenty-five samples were collected from eight different sites in the vicinity of sanjay gandhi national park (sgnp) and screened for the presence of keratinophilic fungi using hair baiting technique for isolation. seventy-three isolates were recovered and identified. the cultures were identified using macro- and micro-morphological features. their identification was also confirmed by the blast search of sequences of the its1-5.8s-its2 rdna region against the ncbi/genbank data and ...201425442920
isolation of keratinophilic fungi from selected soils of sanjay gandhi national park, mumbai (india).one hundred and twenty-five samples were collected from eight different sites in the vicinity of sanjay gandhi national park (sgnp) and screened for the presence of keratinophilic fungi using hair baiting technique for isolation. seventy-three isolates were recovered and identified. the cultures were identified using macro- and micro-morphological features. their identification was also confirmed by the blast search of sequences of the its1-5.8s-its2 rdna region against the ncbi/genbank data and ...201425442920
antioxidant and antifungal potential of pleurotus ostreatus and agrocybe cylindracea basidiocarps and mycelia.basidiocarps of pleurotus ostreatus and agrocybe cylindracea are characterized by high nutritional value and numerous medicinal activities, though bioactivities of their mycelia have not been sufficiently studied. the aim of the study was to evaluate antioxidant and antifungal potentials of p. ostreatus and a. cylindracea basidiocarp extracts, as well as those obtained from mycelia cultivated in common synthetic medium and media enriched with various agro-industrial residues. the free radical sc ...201525483715
antioxidant and antifungal potential of pleurotus ostreatus and agrocybe cylindracea basidiocarps and mycelia.basidiocarps of pleurotus ostreatus and agrocybe cylindracea are characterized by high nutritional value and numerous medicinal activities, though bioactivities of their mycelia have not been sufficiently studied. the aim of the study was to evaluate antioxidant and antifungal potentials of p. ostreatus and a. cylindracea basidiocarp extracts, as well as those obtained from mycelia cultivated in common synthetic medium and media enriched with various agro-industrial residues. the free radical sc ...201525483715
maldi-tof mass spectrometry for rapid identification of clinical fungal isolates based on ribosomal protein biomarkers.this study aimed to evaluate the identification of clinical fungal isolates (yeast and molds) by protein profiling using matrix-assisted laser desorption ionization-time of flight mass spectrometry (maldi-tof/ms). a total of 125 clinical fungal culture isolates (yeast and filamentous fungi) were collected. the test set included 88 yeast isolates (candida albicans, candida glabrata, candida guilliermondii, candida kefyr, candida krusei, candida parapsilosis, candida rugosa, candida tropicalis and ...201525541362
maldi-tof mass spectrometry for rapid identification of clinical fungal isolates based on ribosomal protein biomarkers.this study aimed to evaluate the identification of clinical fungal isolates (yeast and molds) by protein profiling using matrix-assisted laser desorption ionization-time of flight mass spectrometry (maldi-tof/ms). a total of 125 clinical fungal culture isolates (yeast and filamentous fungi) were collected. the test set included 88 yeast isolates (candida albicans, candida glabrata, candida guilliermondii, candida kefyr, candida krusei, candida parapsilosis, candida rugosa, candida tropicalis and ...201525541362
antimicrobial and antioxidant activities and chemical characterization of essential oils of thymusvulgaris, rosmarinus officinalis, and origanum majorana from northeastern méxico.there have been no reports of antifungal activity and composition of extracts from thymus vulgaris, rosmarinus officinalis or origanum majorana from northeastern méxico. antifungal activity of these oils against trichophyton rubrum, trichophyton tonsurans, trichophyton mentagrophytes, microsporum gypseum, microsporum canis and epidermophyton floccosum was measured by diffusion assay. additionally, antibacterial and antioxidant activities were evaluated. antibacterial activity against staphylococ ...201525631514
antimicrobial and antioxidant activities and chemical characterization of essential oils of thymusvulgaris, rosmarinus officinalis, and origanum majorana from northeastern méxico.there have been no reports of antifungal activity and composition of extracts from thymus vulgaris, rosmarinus officinalis or origanum majorana from northeastern méxico. antifungal activity of these oils against trichophyton rubrum, trichophyton tonsurans, trichophyton mentagrophytes, microsporum gypseum, microsporum canis and epidermophyton floccosum was measured by diffusion assay. additionally, antibacterial and antioxidant activities were evaluated. antibacterial activity against staphylococ ...201525631514
antimicrobial and antioxidant properties of satureja montana l. and s. subspicata vis. (lamiaceae).satureja montanal. and s. subspicata vis. (lamiaceae) are used for centuries in traditional medicine of balcanic people in the healing of the lymphatic nodule and respiratory system inflammation. in this paper the amount of total phenols and flavonoids (analyzed by uv/vis spectrophotometry), phenolic compounds profile (analyzed by hplc), antimicrobial and antioxidant activities were studied in samples collected in seven per species populations of s. montanaand s. subspicatain croatia. eight phen ...201525642718
antimicrobial and antioxidant properties of satureja montana l. and s. subspicata vis. (lamiaceae).satureja montanal. and s. subspicata vis. (lamiaceae) are used for centuries in traditional medicine of balcanic people in the healing of the lymphatic nodule and respiratory system inflammation. in this paper the amount of total phenols and flavonoids (analyzed by uv/vis spectrophotometry), phenolic compounds profile (analyzed by hplc), antimicrobial and antioxidant activities were studied in samples collected in seven per species populations of s. montanaand s. subspicatain croatia. eight phen ...201525642718
dermatophytes activate skin keratinocytes via mitogen-activated protein kinase signaling and induce immune responses.dermatophytes cause superficial and cutaneous fungal infections in immunocompetent hosts and invasive disease in immunocompromised hosts. however, the host mechanisms that regulate innate immune responses against these fungi are largely unknown. here, we utilized commercially available epidermal tissues and primary keratinocytes to assess (i) damage induction by anthropophilic, geophilic, and zoophilic dermatophyte strains and (ii) the keratinocyte signaling pathways, transcription factors, and ...201525667269
dermatophytes activate skin keratinocytes via mitogen-activated protein kinase signaling and induce immune responses.dermatophytes cause superficial and cutaneous fungal infections in immunocompetent hosts and invasive disease in immunocompromised hosts. however, the host mechanisms that regulate innate immune responses against these fungi are largely unknown. here, we utilized commercially available epidermal tissues and primary keratinocytes to assess (i) damage induction by anthropophilic, geophilic, and zoophilic dermatophyte strains and (ii) the keratinocyte signaling pathways, transcription factors, and ...201525667269
epidemiological studies on dermatophytosis in human patients in himachal pradesh, india.dermatophytes are among the common fungal agents implicated in superficial skin infections worldwide. they include species of trichophyton, microsporum and epidermophyton. in hot and humid climates of tropical and subtropical regions, the incidence of these pathogens is higher. we present in this article, the epidemiological data regarding the prevalence of different dermatophyte species involved in superficial mycoses in human patients in the state of himachal pradesh (india) and different clin ...201425674437
epidemiological studies on dermatophytosis in human patients in himachal pradesh, india.dermatophytes are among the common fungal agents implicated in superficial skin infections worldwide. they include species of trichophyton, microsporum and epidermophyton. in hot and humid climates of tropical and subtropical regions, the incidence of these pathogens is higher. we present in this article, the epidemiological data regarding the prevalence of different dermatophyte species involved in superficial mycoses in human patients in the state of himachal pradesh (india) and different clin ...201425674437
a new anthraquinone from morinda elliptica ridl.a new anthraquinone, morinquinone, together with 18 known anthraquinones were isolated from the stems of morinda elliptica ridl. their structures were elucidated on the basis of spectroscopic data. they each showed weak inhibitory activity against a susceptible strain of staphylococcus aureus and a methicillin-resistant s. aureus. damnacanthal was effective against microsporum gypseum (mic 1 μg/ml). lucidin was active against entamoeba histolytica (mic 31.25 μg/ml) and giardia intestinalis (mic ...201525686628
a new anthraquinone from morinda elliptica ridl.a new anthraquinone, morinquinone, together with 18 known anthraquinones were isolated from the stems of morinda elliptica ridl. their structures were elucidated on the basis of spectroscopic data. they each showed weak inhibitory activity against a susceptible strain of staphylococcus aureus and a methicillin-resistant s. aureus. damnacanthal was effective against microsporum gypseum (mic 1 μg/ml). lucidin was active against entamoeba histolytica (mic 31.25 μg/ml) and giardia intestinalis (mic ...201525686628
distribution of keratinophilic fungi in soil across tunisia: a descriptive study and review of the literature.data on the frequency and distribution of keratinophilic fungi in soil of tunisia are scanty. the present survey aimed to describe the distribution of keratinophilic fungi in soils collected in tunisia. keratinophilic fungi were isolated using vanbreuseghem's hair-baiting technique from 354 soil samples collected in 15 governorates of tunisia and identified according to their morphology with further dna and maldi-tof analysis when necessary. keratinophilic fungi were isolated from 46.3 % of the ...201525690159
distribution of keratinophilic fungi in soil across tunisia: a descriptive study and review of the literature.data on the frequency and distribution of keratinophilic fungi in soil of tunisia are scanty. the present survey aimed to describe the distribution of keratinophilic fungi in soils collected in tunisia. keratinophilic fungi were isolated using vanbreuseghem's hair-baiting technique from 354 soil samples collected in 15 governorates of tunisia and identified according to their morphology with further dna and maldi-tof analysis when necessary. keratinophilic fungi were isolated from 46.3 % of the ...201525690159
onychomycosis in north-east of iran.onychomycosis is a common fungal infection which has been conducted in many parts of the world. the aim of this study was to evaluate the epidemiology and to identify the aetiological factors of onychomycosis in mazandaran province, iran.201425705360
onychomycosis in north-east of iran.onychomycosis is a common fungal infection which has been conducted in many parts of the world. the aim of this study was to evaluate the epidemiology and to identify the aetiological factors of onychomycosis in mazandaran province, iran.201425705360
therapeutic switching: from antidermatophytic essential oils to new leishmanicidal products.this study examined whether the antidermatophytic activity of essential oils (eos) can be used as an indicator for the discovery of active natural products against leishmania amazonensis. the aerial parts of seven plants were hydrodistilled. using broth microdilution techniques, the obtained eos were tested against three strains of dermatophytes (trichophyton mentagrophytes, microsporum gypseum and microsporum canis). to compare the eos antifungal and antiparasitic effects, the eos activities ag ...201525714080
therapeutic switching: from antidermatophytic essential oils to new leishmanicidal products.this study examined whether the antidermatophytic activity of essential oils (eos) can be used as an indicator for the discovery of active natural products against leishmania amazonensis. the aerial parts of seven plants were hydrodistilled. using broth microdilution techniques, the obtained eos were tested against three strains of dermatophytes (trichophyton mentagrophytes, microsporum gypseum and microsporum canis). to compare the eos antifungal and antiparasitic effects, the eos activities ag ...201525714080
therapeutic switching: from antidermatophytic essential oils to new leishmanicidal products.this study examined whether the antidermatophytic activity of essential oils (eos) can be used as an indicator for the discovery of active natural products against leishmania amazonensis. the aerial parts of seven plants were hydrodistilled. using broth microdilution techniques, the obtained eos were tested against three strains of dermatophytes (trichophyton mentagrophytes, microsporum gypseum and microsporum canis). to compare the eos antifungal and antiparasitic effects, the eos activities ag ...201525742270
therapeutic switching: from antidermatophytic essential oils to new leishmanicidal products.this study examined whether the antidermatophytic activity of essential oils (eos) can be used as an indicator for the discovery of active natural products against leishmania amazonensis. the aerial parts of seven plants were hydrodistilled. using broth microdilution techniques, the obtained eos were tested against three strains of dermatophytes (trichophyton mentagrophytes, microsporum gypseum and microsporum canis). to compare the eos antifungal and antiparasitic effects, the eos activities ag ...201525742270
a new hydronaphthalenone from the mangrove-derived daldinia eschscholtzii psu-std57.one new hydronaphthalenone derivative (1) was isolated from the broth extract of the endophytic fungus daldinia eschscholtzii psu-std57 together with five known compounds, isosclerone (2), 8-methoxy-1-naphthol, 1,8-dimethoxynaphthalene, 2,6-dihydroxyphenyl-1-butan-1-one and tyrosol. the structures were assigned by spectroscopic methods. all the compounds were tested for antimicrobial activity against staphylococcus aureus, methicillin-resistant s. aureus and microsporum gypseum.201525776658
a new hydronaphthalenone from the mangrove-derived daldinia eschscholtzii psu-std57.one new hydronaphthalenone derivative (1) was isolated from the broth extract of the endophytic fungus daldinia eschscholtzii psu-std57 together with five known compounds, isosclerone (2), 8-methoxy-1-naphthol, 1,8-dimethoxynaphthalene, 2,6-dihydroxyphenyl-1-butan-1-one and tyrosol. the structures were assigned by spectroscopic methods. all the compounds were tested for antimicrobial activity against staphylococcus aureus, methicillin-resistant s. aureus and microsporum gypseum.201525776658
nicotine-degrading microorganisms and their potential applications.nicotine-degrading microorganisms (ndms) are a special microbial group which can use nicotine as the sole carbon and nitrogen source for growth. since the 1950s, the bioconversion of nicotine by microbes has received increasing attention, and several ndms have been identified, such as arthrobacter nicotinovorans, microsporum gypseum, pellicularia filamentosa jts-208, and pseudomonas sp. 41. in recent years, increasing numbers of ndms have been isolated and identified from tobacco plantation soil ...201525805341
nicotine-degrading microorganisms and their potential applications.nicotine-degrading microorganisms (ndms) are a special microbial group which can use nicotine as the sole carbon and nitrogen source for growth. since the 1950s, the bioconversion of nicotine by microbes has received increasing attention, and several ndms have been identified, such as arthrobacter nicotinovorans, microsporum gypseum, pellicularia filamentosa jts-208, and pseudomonas sp. 41. in recent years, increasing numbers of ndms have been isolated and identified from tobacco plantation soil ...201525805341
in vitro and in vivo antidermatophytic activities of some iranian medicinal plants.in the last decades, the number of people suffering from dermatophytoses has seriously increased, which may be due to the development of resistant strains to a range of antifungal drugs. the present study was aimed to evaluate the antidermatophytic properties of eight extracts from the selected spices and herbs, which were ethno-medicinally used in iran against trichophyton mentagrophytes, trichophyton interdigitale, microsporum canis, and microsporum gypseum (10 strain of each). the in vitro an ...201526092105
in vitro and in vivo antidermatophytic activities of some iranian medicinal plants.in the last decades, the number of people suffering from dermatophytoses has seriously increased, which may be due to the development of resistant strains to a range of antifungal drugs. the present study was aimed to evaluate the antidermatophytic properties of eight extracts from the selected spices and herbs, which were ethno-medicinally used in iran against trichophyton mentagrophytes, trichophyton interdigitale, microsporum canis, and microsporum gypseum (10 strain of each). the in vitro an ...201526092105
antidermatophytic activity of mikania micrantha kunth: an invasive weed.the incidence of dermatophytosis has risen dramatically in recent years. limited availability of side-effect free drugs has led to a search for new antidermatophytic agents.201526109783
antidermatophytic activity of mikania micrantha kunth: an invasive weed.the incidence of dermatophytosis has risen dramatically in recent years. limited availability of side-effect free drugs has led to a search for new antidermatophytic agents.201526109783
a multi-target approach toward the development of novel candidates for antidermatophytic activity: ultrastructural evidence on α-bisabolol-treated microsporum gypseum.multi-target strategies are directed toward targets that are unrelated (or distantly related) and can create opportunities to address different pathologies. the antidermatophytic activities of nine natural skin lighteners: α-bisabolol, kojic acid, β-arbutin, azelaic acid, hydroquinone, nicotinamide, glycine, glutathione and ascorbyl tetraisopalmitate, were evaluated, in comparison with the known antifungal drug fluconazole, on nine dermatophytes responsible for the most common dermatomycoses: mi ...201526132903
a multi-target approach toward the development of novel candidates for antidermatophytic activity: ultrastructural evidence on α-bisabolol-treated microsporum gypseum.multi-target strategies are directed toward targets that are unrelated (or distantly related) and can create opportunities to address different pathologies. the antidermatophytic activities of nine natural skin lighteners: α-bisabolol, kojic acid, β-arbutin, azelaic acid, hydroquinone, nicotinamide, glycine, glutathione and ascorbyl tetraisopalmitate, were evaluated, in comparison with the known antifungal drug fluconazole, on nine dermatophytes responsible for the most common dermatomycoses: mi ...201526132903
disseminated favus caused by microsporum gypseum in a patient with systemic lupus erythematosus. 201626259050
disseminated favus caused by microsporum gypseum in a patient with systemic lupus erythematosus. 201626259050
pseudomembranous-like tinea of the scrotum infected by microsporum gypseum in a young man.microsporum gypseum is a geographically widespread geophilic fungus that infects animals and humans. m. gypseum infection on the scrotum is very rare and can be easily misdiagnosed because of a lack of inflammatory reaction. here we describe a patient with pseudomembranous-like tinea of the scrotum resulting from m. gypseum.201726288444
pseudomembranous-like tinea of the scrotum infected by microsporum gypseum in a young man.microsporum gypseum is a geographically widespread geophilic fungus that infects animals and humans. m. gypseum infection on the scrotum is very rare and can be easily misdiagnosed because of a lack of inflammatory reaction. here we describe a patient with pseudomembranous-like tinea of the scrotum resulting from m. gypseum.201726288444
chalcone derivatives as potential antifungal agents: synthesis, and antifungal activity.much research has been carried out with the aim to discover the therapeutic values of chalcone derivatives. chalcones possess wide range of pharmacological activity such as antibacterial, antimalarial, antiprotozoal, antitubercular, anticancer, and antifungal agents etc. the presence of reactive α,β-unsaturated keto group in chalcones is found to be responsible for their biological activity. the rapid developments of resistance to antifungal agents, led to design, and synthesize the new antifung ...201726317075
chalcone derivatives as potential antifungal agents: synthesis, and antifungal activity.much research has been carried out with the aim to discover the therapeutic values of chalcone derivatives. chalcones possess wide range of pharmacological activity such as antibacterial, antimalarial, antiprotozoal, antitubercular, anticancer, and antifungal agents etc. the presence of reactive α,β-unsaturated keto group in chalcones is found to be responsible for their biological activity. the rapid developments of resistance to antifungal agents, led to design, and synthesize the new antifung ...201726317075
synthesis, antifungal and antibacterial activity of novel 1,2,4-triazole derivatives.a large number of 1,2,4-triazole-containing ring system have been incorporated into a wide variety of therapeutically interesting drug candidates including anti-inflammatory, central nervous system stimulants, antianxiety, and antimicrobial agents. to overcome the rapid development of drug resistance, new agents should preferably have chemical characteristics that clearly differ from those of existing agents. thus led to the design and synthesize the new antimicrobial agents. a novel series of s ...201726317080
synthesis, antifungal and antibacterial activity of novel 1,2,4-triazole derivatives.a large number of 1,2,4-triazole-containing ring system have been incorporated into a wide variety of therapeutically interesting drug candidates including anti-inflammatory, central nervous system stimulants, antianxiety, and antimicrobial agents. to overcome the rapid development of drug resistance, new agents should preferably have chemical characteristics that clearly differ from those of existing agents. thus led to the design and synthesize the new antimicrobial agents. a novel series of s ...201726317080
dermatophytosis: a 16-year retrospective study in a metropolitan area in southern brazil.dermatophytoses are considered a public health problem. the objectives of this study were to determine the evolution of their prevalence in the metropolitan area of porto alegre, brazil, and to analyze the dermatophyte species distribution according to body site and demographic characteristics of the patients.201526322879
dermatophytosis: a 16-year retrospective study in a metropolitan area in southern brazil.dermatophytoses are considered a public health problem. the objectives of this study were to determine the evolution of their prevalence in the metropolitan area of porto alegre, brazil, and to analyze the dermatophyte species distribution according to body site and demographic characteristics of the patients.201526322879
dermatophytosis due to microsporum incurvatum: notification and identification of a neglected pathogenic species.a 4-year-old iranian boy developed erythematous, itchy and annular lesion on his face. microscopic examination of the scraped samples with 10 % potassium hydroxide (koh) revealed fungal septate hyphae and arthroconidia. the etiological agent was found to be microsporum gypseum in mycological examinations. amplification and restriction digestion of the internal transcribed spacers (its) of rdna was not helpful for identification, but in its sequencing the isolate showed 98 % homology to microspor ...201626386581
dermatophytosis due to microsporum incurvatum: notification and identification of a neglected pathogenic species.a 4-year-old iranian boy developed erythematous, itchy and annular lesion on his face. microscopic examination of the scraped samples with 10 % potassium hydroxide (koh) revealed fungal septate hyphae and arthroconidia. the etiological agent was found to be microsporum gypseum in mycological examinations. amplification and restriction digestion of the internal transcribed spacers (its) of rdna was not helpful for identification, but in its sequencing the isolate showed 98 % homology to microspor ...201626386581
polyhydroxyalkanoate-based 3-hydroxyoctanoic acid and its derivatives as a platform of bioactive compounds.a library of 18 different compounds was synthesized starting from (r)-3-hydroxyoctanoic acid which is derived from the bacterial polymer polyhydroxyalkanoate (pha). ten derivatives, including halo and unsaturated methyl and benzyl esters, were synthesized and characterized for the first time. given that (r)-3-hydroxyalkanoic acids are known to have biological activity, the new compounds were evaluated for antimicrobial activity and in vitro antiproliferative effect with mammalian cell lines. the ...201626399414
polyhydroxyalkanoate-based 3-hydroxyoctanoic acid and its derivatives as a platform of bioactive compounds.a library of 18 different compounds was synthesized starting from (r)-3-hydroxyoctanoic acid which is derived from the bacterial polymer polyhydroxyalkanoate (pha). ten derivatives, including halo and unsaturated methyl and benzyl esters, were synthesized and characterized for the first time. given that (r)-3-hydroxyalkanoic acids are known to have biological activity, the new compounds were evaluated for antimicrobial activity and in vitro antiproliferative effect with mammalian cell lines. the ...201626399414
inactivation of human pathogenic dermatophytes by non-thermal plasma.non-thermal plasma (ntp) was tested as an in vitro deactivation method on four human pathogenic dermatophytes belonging to all ecological groups including anthropophilic trichophyton rubrum and trichophyton interdigitale, zoophilic arthroderma benhamiae, and geophilic microsporum gypseum. the identification of all strains was confirmed by sequencing of its rdna region (internal transcribed spacer region of ribosomal dna). dermatophyte spores were suspended in water or inoculated on agar plates a ...201526427826
inactivation of human pathogenic dermatophytes by non-thermal plasma.non-thermal plasma (ntp) was tested as an in vitro deactivation method on four human pathogenic dermatophytes belonging to all ecological groups including anthropophilic trichophyton rubrum and trichophyton interdigitale, zoophilic arthroderma benhamiae, and geophilic microsporum gypseum. the identification of all strains was confirmed by sequencing of its rdna region (internal transcribed spacer region of ribosomal dna). dermatophyte spores were suspended in water or inoculated on agar plates a ...201526427826
in vitro activity of twenty commercially available, plant-derived essential oils against selected dermatophyte species.the in vitro activity of twenty chemically defined essential oils (eos) obtained from boswellia sacra, citrus bergamia, c. limon, c. medica, cinnamomum zeylanicum, eucalyptus globulus, foeniculum vulgare, helichrysum italicum, illicium verum, litsea cubeba, mentha spicata, myrtus communis, ocimum basilicum, origanum majorana, o. vulgare, pelargonium graveolens, rosmarinus officinalis, santalum album, satureja montana, and thymus serpyllum was assayed against clinical animal isolates of microspor ...201526434145
in vitro activity of twenty commercially available, plant-derived essential oils against selected dermatophyte species.the in vitro activity of twenty chemically defined essential oils (eos) obtained from boswellia sacra, citrus bergamia, c. limon, c. medica, cinnamomum zeylanicum, eucalyptus globulus, foeniculum vulgare, helichrysum italicum, illicium verum, litsea cubeba, mentha spicata, myrtus communis, ocimum basilicum, origanum majorana, o. vulgare, pelargonium graveolens, rosmarinus officinalis, santalum album, satureja montana, and thymus serpyllum was assayed against clinical animal isolates of microspor ...201526434145
essential oil of algerian eucalyptus citriodora: chemical composition, antifungal activity.essential oil of eucalyptus citriodora is a natural product which has been attributed for various medicinal uses. in the present investigation, e. citriodora essential oil was used to evaluate its antifungal effect against medically important dermatophytes.201526597375
essential oil of algerian eucalyptus citriodora: chemical composition, antifungal activity.essential oil of eucalyptus citriodora is a natural product which has been attributed for various medicinal uses. in the present investigation, e. citriodora essential oil was used to evaluate its antifungal effect against medically important dermatophytes.201526597375
antidermatophytic activity of hydroalcoholic extracts from rosmarinus officinalis and tetradenia riparia.rosmarinus officinalis and tetradenia riparia are used in folk medicine for the treatment of disease, including infectious diseases and skin disorders. the purpose of this study was to investigate the antifungal activity of hydroalcoholic extracts from r. officinalis and t. riparia against strains of trichophyton rubrum, t. mentagrophytes and microsporum gypseum. hydroalcoholic extracts prepared with dried leaves from r. officinalis, psidium guajava and t. riparia were assayed against dermatophy ...201526603099
antidermatophytic activity of hydroalcoholic extracts from rosmarinus officinalis and tetradenia riparia.rosmarinus officinalis and tetradenia riparia are used in folk medicine for the treatment of disease, including infectious diseases and skin disorders. the purpose of this study was to investigate the antifungal activity of hydroalcoholic extracts from r. officinalis and t. riparia against strains of trichophyton rubrum, t. mentagrophytes and microsporum gypseum. hydroalcoholic extracts prepared with dried leaves from r. officinalis, psidium guajava and t. riparia were assayed against dermatophy ...201526603099
antiproliferative effect and characterization of a novel antifungal peptide derived from human chromogranin a.cga-n46 is a novel antifungal peptide derived from the n-terminus of human chromogranin a, corresponding to the 31st to 76th amino acids. further research on its activities and characteristics may be helpful for the application of cga-n46 in medical or other situations. in the present study, the antifungal spectrum and physicochemical characteristics of cga-n46 were investigated using an antifungal assay, its antiproliferative effects on cancer and normal cells were assessed using mtt assay and ...201526668630
antiproliferative effect and characterization of a novel antifungal peptide derived from human chromogranin a.cga-n46 is a novel antifungal peptide derived from the n-terminus of human chromogranin a, corresponding to the 31st to 76th amino acids. further research on its activities and characteristics may be helpful for the application of cga-n46 in medical or other situations. in the present study, the antifungal spectrum and physicochemical characteristics of cga-n46 were investigated using an antifungal assay, its antiproliferative effects on cancer and normal cells were assessed using mtt assay and ...201526668630
chemical composition and antifungal activity of essential oil from eucalyptus smithii against dermatophytes.in this study, we evaluated the chemical composition of a commercial sample of essential oil from eucalyptus smithii r.t. baker and its antifungal activity against microsporum canis atcc 32903, microsporum gypseum atcc 14683, trichophyton mentagrophytes atcc 9533, t. mentagrophytes atcc 11480, t. mentagrophytes atcc 11481, and trichophyton rubrum cct 5507.201526676500
chemical composition and antifungal activity of essential oil from eucalyptus smithii against dermatophytes.in this study, we evaluated the chemical composition of a commercial sample of essential oil from eucalyptus smithii r.t. baker and its antifungal activity against microsporum canis atcc 32903, microsporum gypseum atcc 14683, trichophyton mentagrophytes atcc 9533, t. mentagrophytes atcc 11480, t. mentagrophytes atcc 11481, and trichophyton rubrum cct 5507.201526676500
detection of seasonal asymptomatic dermatophytes in van cats.the van cat is a domestic landrace found in the van province of eastern turkey. in this study, we aimed to determine the seasonal carriage of dermatophytes in van cats without clinical lesions. a total of 264 hair specimens were collected from clinically healthy cats in and around the van province. of these samples, 30.3% were obtained in spring, 30.6% in summer, 16.6% in autumn, and 22.3% in winter; 45.1% of samples were from male cats and the rest from female ones. of the studied cats, 118 wer ...201626887249
detection of seasonal asymptomatic dermatophytes in van cats.the van cat is a domestic landrace found in the van province of eastern turkey. in this study, we aimed to determine the seasonal carriage of dermatophytes in van cats without clinical lesions. a total of 264 hair specimens were collected from clinically healthy cats in and around the van province. of these samples, 30.3% were obtained in spring, 30.6% in summer, 16.6% in autumn, and 22.3% in winter; 45.1% of samples were from male cats and the rest from female ones. of the studied cats, 118 wer ...201626887249
tinea faciei caused by trichophyton mentagrophytes in a 20-day-old neonate.although candidiasis in newborns is not uncommon, superficial dermatophyte infections of infants is quite rare. the causative agents of neonatal tinea reported in various case studies have been trichophyton rubrum, microsporum canis, microsporum gypseum, and trichophyton violaceum. to the best of our knowledge, no case report of neonatal tinea faciei caused by trichophyton mentagrophytes has been reported earlier.201526904450
tinea faciei caused by trichophyton mentagrophytes in a 20-day-old neonate.although candidiasis in newborns is not uncommon, superficial dermatophyte infections of infants is quite rare. the causative agents of neonatal tinea reported in various case studies have been trichophyton rubrum, microsporum canis, microsporum gypseum, and trichophyton violaceum. to the best of our knowledge, no case report of neonatal tinea faciei caused by trichophyton mentagrophytes has been reported earlier.201526904450
dermatophytic infections among the patients attending di skin hospital and research center at maharajgunj kathmandu.dermatophytosis is the common and most significant superficial fungal infections because of their widespread involvement among the people all over the world. the clinical presentation, though very typical of ringworm infection, is often confused with other skin disorders, making laboratory diagnosis and confirmation necessary. the aim of this research is to study different clinical variants of dermatophytosis and its associated risk factor among the patients attending di skin hospital and resear ...201627005717
dermatophytic infections among the patients attending di skin hospital and research center at maharajgunj kathmandu.dermatophytosis is the common and most significant superficial fungal infections because of their widespread involvement among the people all over the world. the clinical presentation, though very typical of ringworm infection, is often confused with other skin disorders, making laboratory diagnosis and confirmation necessary. the aim of this research is to study different clinical variants of dermatophytosis and its associated risk factor among the patients attending di skin hospital and resear ...201627005717
detection and characterization of zoonotic dermatophytes from dogs and cats in and around kolkata.the ringworms of pet dogs, cats, and stray animals (dogs, cats, and other animals) could be a potential source of zoonotic infections causing a serious public health problem in the busy city kolkata. the pet owners are more susceptible to get this infection from their pets, because of the close contact with them as dermatophytosis is very much prevalent in those pets. so, this study was aimed to check the prevalence of dermatophytosis in dogs, cats, and in pet owners.201527047202
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