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effects of theaflavins on melanin biosynthesis in mouse b16 melanoma cells.in this study, we examined the effects of theaflavins, polyphenols in black tea, on alpha melanocyte-stimulating hormone (alphamsh)-induced melanogenesis in mouse b16 melanoma cells. among theaflavins, theaflavin-3,3'-digallate (tf-3) exhibited a potent inhibitory effect on melanogenesis. our results indicate that the inhibitory effect of tf-3 on melanogenesis is due to suppression of tyrosinase protein and mrna levels.200919502752
stimulated parametric emission microscopy.we propose a novel microscopy technique based on the four-wave mixing (fwm) process that is enhanced by two-photon electronic resonance induced by a pump pulse along with stimulated emission induced by a dump pulse. a ti:sapphire laser and an optical parametric oscillator are used as light sources for the pump and dump pulses, respectively. we demonstrate that our proposed fwm technique can be used to obtain a one-dimensional image of ethanol-thinned coumarin 120 solution sandwiched between a ho ...200619503398
increase of theaflavin gallates and thearubigins by acceleration of catechin oxidation in a new fermented tea product obtained by the tea-rolling processing of loquat ( eriobotrya japonica ) and green tea leaves.in a project to produce a new fermented tea product from non-used tea leaves harvested in the summer, we found that kneading tea leaves ( camellia sinensis ) with fresh loquat leaves ( eriobotrya japonica ) accelerated the enzymatic oxidation of tea catechins. the fermented tea obtained by tea-rolling processing of tea and loquat leaves had a strong, distinctive flavor and a plain aftertaste, which differed from usual black, green, and oolong teas. the phenolic constituents were similar to those ...200919507893
online gas chromatography combustion/pyrolysis-isotope ratio mass spectrometry (hrgc-c/p-irms) of (+/-)-dihydroactinidiolide from tea ( camellia sinensis ) and rooibos tea ( aspalathus linearis ).online capillary gas chromatography-isotope ratio mass spectrometry in both the combustion and the pyrolysis modes (hrgc-c/p-irms) was employed to perform authentication studies of the flavoring agent (+/-)-dihydroactinidiolide. thus, the delta(13)c(v-pdb) and delta(2)h(v-smow) values of synthetic (ex synthetic beta-ionone and natural beta-carotene) as well as enzymatically (ex synthetic and natural beta-carotene) produced references were studied in comparison with those of the natural substance ...200919514730
dietary pattern, the metabolic syndrome, and left ventricular mass and systolic function: the multi-ethnic study of atherosclerosis.little is known about the relations between dietary patterns, metabolic dysfunction, and left ventricular (lv) function.200919515735
black tea consumption dose-dependently improves flow-mediated dilation in healthy males.flavonoids may protect against cardiovascular disease. tea is a major source of dietary flavonoids. studies indicate black tea improves endothelial function but data on arterial haemodynamics, blood pressure (bp) and insulin resistance are equivocal. inconsistency may be due to flaws in study design or flavonoid doses tested. further, no study has evaluated the dose-response curve. our study aimed to test the effects of various doses of black tea on vascular function, bp and insulin resistance.200919516176
tea polyphenols inhibit cyclooxygenase-2 expression and block activation of nuclear factor-kappa b and akt in diethylnitrosoamine induced lung tumors in swiss mice.due to lack of validated screening methods and hence poor prognosis, treatment of lung cancer has not still improved up to the expectations. therefore, risk of lung cancer needs to be minimized by efficient preventive measures. tea (camellia sinensis) and its bioactive polyphenols have been associated with prevention of human cancer for several organs. thus, intake of tea polyphenols seems to be a viable mean to control lung cancer burden. in the present study, we studied the chemopreventive eff ...201019517063
black tea polyphenols target matrix metalloproteinases, reck, proangiogenic molecules and histone deacetylase in a rat hepatocarcinogenesis model.the aim of this study was to evaluate the chemopreventive effects of black tea polyphenols (polyphenon-b) on markers of invasion and angiogenesis during dimethylaminoazobenzene (dab)-induced hepatocarcinogenesis.200919528495
acylated oleanane-type triterpene saponins with acceleration of gastrointestinal transit and inhibitory effect on pancreatic lipase from flower buds of chinese tea plant (camellia sinensis).the meoh extract and its buoh-soluble fraction (crude saponin fraction) from the flower buds of chinese tea plant (camellia sinensis (l.) o. kuntze; fujian province) were found to exhibit accelerating effects on gastrointestinal transit in mice and inhibitory effects against pancreatic lipase. from the buoh-soluble fraction, three new acylated oleanane-type triterpene oligoglycosides, chakasaponins i, ii, and iii (1-3, resp.), were isolated together with 13 known compounds. the chemical structur ...200919551732
induction of apoptosis by tea polyphenols mediated through mitochondrial cell death pathway in mouse skin tumors.many naturally occurring phytochemicals have shown cancer chemopreventive potential in a variety of bioassay systems. one such naturally occurring biologically active compound is tea camellia sinensis, which is the most consumed beverage in the world after water. the most abundant and active constituents of tea are polyphenols (epigallocatechin gallate and theaflavins). in the present study, cancer chemopreventive properties of both black tea polyphenols (btp) and green tea polyphenols (gtp) on ...200919556852
quantitation of chafurosides a and b in tea leaves and isolation of prechafurosides a and b from oolong tea leaves.a procedure was developed for the quantitative determination of chafuroside a, a flavone c-glycoside with potent anti-inflammatory activity, and its regioisomer chafuroside b, as well as isovitexin and vitexin, by selected reaction monitoring liquid chromatography-tandem mass spectrometry (srm lc-ms/ms) analysis. this method was successfully applied to commercial leaves of green tea, houji tea, oolong tea, and black tea. high levels of chafurosides a and b were found in oolong tea leaves that ha ...200919572651
inhibitory effect of tea polyphenols on local tissue damage induced by snake venoms.the methanolic extract of fresh tea leaves of camellia sinensis l. (theaceae) (cs) was assayed for its potential to inhibit enzymes with hydrolytic activity in naja naja kaouthia lesson (elapidae) and calloselasma rhodostoma kuhl (viperidae) venoms. these snake venom enzymes are responsible for the early effects of envenomation, such as local tissue damage and inflammation. the cs extract inhibited phospholipase a(2), proteases, hyaluronidase and l-amino acid oxidase in both venoms by in vitro n ...201019585481
how would you like your tea, vicar?scald injuries are the commonest cause of paediatric burns leading to hospital admission both in the united kingdom (national burn care review committee report; 2001) and around the world. the cost and significant morbidity resulting from scald injuries reiterates the need for effective prevention campaigns for primary caregivers. the majority of scalds in children occur in the kitchen (49%) at home. three children a day under the age of 5 (1100/year) are involved in scalds resulting from pullin ...201019586723
green tea (camellia sinensis) for the prevention of cancer.tea is one of the most commonly consumed beverages worldwide. teas from the plant camellia sinensis can be grouped into green, black and oolong tea. cross-culturally tea drinking habits vary. camellia sinensis contains the active ingredient polyphenol, which has a subgroup known as catechins. catechins are powerful antioxidants. it has been suggested that green tea polyphenol may inhibit cell proliferation and observational studies have suggested that green tea may have cancer-preventative effec ...200919588362
role of oxidation-triggered activation of jnk and p38 mapk in black tea polyphenols induced apoptotic death of a375 cells.theaflavins (tf) and thearubigins (tr) are the major polyphenols of black tea. our previous study revealed that tf- and tr-induced apoptosis of human malignant melanoma cells (a375) is executed via a mitochondria-mediated pathway. in our present study we observed the role of the three most important mapk (erk, jnk, and p38) in tf- and tr-induced apoptosis. tf and tr treatment of a375 cells led to sustained activation of jnk and p38 mapk but not erk, suggesting that jnk and p38 are the effector m ...200919594545
coffee and black tea consumption and risk of breast cancer by estrogen and progesterone receptor status in a swedish cohort.coffee and tea consumption has been inconsistently associated with the risk of breast cancer. we examined the associations of caffeinated coffee and black tea consumption with the incidence of breast cancer, overall and by estrogen receptor (er) and progesterone receptor (pr) status of the tumor, in the swedish mammography cohort.200919597749
oxidation of the dihydrochalcone aspalathin leads to dimerization.aspalathin and nothofagin are typical ingredients of unfermented rooibos (krafczyk, n.; glomb, m. a. j. agric. food chem. 2008, 56, 3368). during oxidation these dihydrochalcones were degraded to higher molecular weight browning products under aerated and nonenzymatic conditions. in the early stages of browning reactions aspalathin formed two dimers. these two compounds were unequivocally established as atropisomers stemming from oxidative a to b ring coupling. multilayer countercurrent chromato ...200919601579
toxic and essential mineral elements content of black tea leaves and their tea infusions consumed in iran.the metal contents of eleven black tea samples, four cultivated in iran and seven imported, and their tea infusions were determined. twelve elements consisting toxic metals (al, as, pb, cr, cd, and ni) and essential mineral elements (fe, zn, cu, mn, ca, and mg) were analyzed using inductively coupled plasma atomic emission spectroscopy (icp-aes). al, ca, mg, and mn ranged in black tea leaves at mg g(-1) levels, while cr, fe, ni, cu, zn were at microg g(-1) levels. analysis of variance showed no ...201019609493
catechin and catechin fractions as biochemical markers to study the diversity of indian tea (camellia sinensis (l.) o. kuntze) germplasm.the heterogeneous indian tea germplasm includes 'china', 'assam', 'cambod', and their hybrids which were evaluated using biochemical markers viz., total catechin and their fractions, for varietal identification and characterization. principal component analysis (pca) of biochemical characters showed that the total catechin and trihydroxylated catechin has higher eigenvalues. the first two principal components (pcs) could differentiate more than 90% of the clones studied. this grouping based on f ...200919623550
speciation and separation of cr(vi) and cr(iii) using coprecipitation with ni2+/2-nitroso-1-naphthol-4-sulfonic acid and determination by faas in water and food samples.a speciation procedure for chromium(iii) and chromium(vi) in the water and food samples has been established in the presented work. the procedure presented based on quantitative recoveries of cr(iii)>95% using coprecipitation of ni(2+)/2-nitroso-1-naphthol-4-sulfonic acid. the total chromium was measured after reduction of cr(vi) by concentrated h(2)so(4) and ethanol. the cr(vi) was calculated as the difference between the total cr content and the cr(iii) contents. the analytical variables, ph, ...200919632291
dietary phenolics: chemistry, bioavailability and effects on health.there is much epidemiological evidence that diets rich in fruit and vegetables can reduce the incidence of non-communicable diseases such as cardiovascular diseases, diabetes, cancer and stroke. these protective effects are attributed, in part, to phenolic secondary metabolites. this review summarizes the chemistry, biosynthesis and occurrence of the compounds involved, namely the c6-c3-c6 flavonoids-anthocyanins, dihydrochalcones, flavan-3-ols, flavanones, flavones, flavonols and isoflavones. i ...200919636448
acute hepatitis after treatment for hair loss with oral green tea extracts (camellia sinensis).nutritional additives based on green tea have been claiming various beneficial health effects. however, several case reports on hepatotoxicity after the intake of green tea derivatives containing camellia sinensis have been published. we report a patient with an acute hepatitis after intake of an oral green tea derivative claiming protection against hair loss, showing a histological image compatible with drug induced hepatitis. other important causes of hepatitis were excluded. after cessation o ...201619637786
purified black tea theaflavins and theaflavins/catechin supplements did not affect serum lipids in healthy individuals with mildly to moderately elevated cholesterol concentrations.ingestion of tea flavonoids found in both green and black tea is linked to cardiovascular health benefits such as lowering serum lipids. evidence for a cholesterol-lowering benefit of green or black tea consumption from human intervention studies is, however, conflicting and active components responsible for the effect have not yet been clearly identified.201019639377
changes in the composition of raw tea leaves from the korean yabukida plant during high-temperature processing to pan-fried kamairi-cha green tea.to develop a better understanding of compositional changes occurring during the production of commercial teas, we determined by high-performance liquid chromatography (hplc) changes in ingredient levels during each of several manufacturing steps used to produce kamairi-cha, a premium green tea. kamairi-cha uses pan-frying instead of the usual blanching technique to inactivate the enzymes responsible for producing traditional black tea. the resulting tea lacks the characteristic bitterness of gre ...200919646035
green tea extract weakens the antibacterial effect of amoxicillin in methicillin-resistant staphylococcus aureus infected mice.tea (camellia sinensis) has been known for its modulation of resistance of methicillin-resistant staphylococcus aureus (mrsa) to beta-lactam antibiotics in vitro. this study aimed to confirm the in vitro effect of green tea extracts with beta-lactams and to determine whether green tea extracts can reduce the minimum inhibitory concentrations (mics) of amoxicillin in mrsa-infected mice. the catechins in the test tea that account for the reduced resistance to beta-lactams were quantitatively deter ...201019653316
green tea epigallocatechin-3-gallate inhibits microsomal prostaglandin e(2) synthase-1.prostaglandin (pg)e(2) is a critical lipid mediator connecting chronic inflammation to cancer. the anti-carcinogenic epigallocatechin-3-gallate (egcg) from green tea (camellia sinensis) suppresses cellular pge(2) biosynthesis, but the underlying molecular mechanisms are unclear. here, we investigated the interference of egcg with enzymes involved in pge(2) biosynthesis, namely cytosolic phospholipase (cpl)a(2), cyclooxygenase (cox)-1 and -2, and microsomal prostaglandin e(2) synthase-1 (mpges-1) ...200919665000
ethylamine content and theanine biosynthesis in different organs of camellia sinensis seedlings.we examined the distribution of ethylamine, glutamic acid and alanine, which are utilized in theanine biosynthesis, and other major amino acids in leaves, stems, cotyledons and roots of 6-week-old tea seedlings. ethylamine and glutamic acid, which are substrates of theanine synthetase, were distributed almost uniformly in all parts of the seedlings; the contents in micromol/g fresh wt varied from 0.44-0.88 (ethylamine) and 1.6-2.4 (glutamic acid). the content of alanine, a possible precursor of ...201519678543
effects of sour tea (hibiscus sabdariffa) on lipid profile and lipoproteins in patients with type ii diabetes.there is increasing evidence that intake of sour tea (hibiscus sabdariffa) has hypoglycemic and hypolipidemic effects and may benefit patients suffering from metabolic disorders such as diabetes. the objective of the present study was to investigate the hypolipidemic effects of sour tea in patients with diabetes and compare them with those of black tea.200919678781
fate of imidacloprid and acetamiprid residues during black tea manufacture and transfer into tea infusion.the objective of this paper is to investigate the loss/stability of neonicotinoids (imidacloprid and acetamiprid) residues during the manufacture of black tea and to study the transfer of these pesticides from made tea to its infusion. for orthodox black tea, the manufacturing process involves leaf harvesting (plucking two leaves and a bud), withering, rolling, fermentation (oxidation), and drying. initial withering and final drying resulted in the loss of pesticide residues, but no significant ...200919680885
health potential for functional green teas?obesity is a major health problem in the developed and developing world. many "functional" foods and ingredients are advocated for their effects on body composition but few have consistent scientific support for their efficacy. however, an increasing amount of mechanistic and clinical evidence is building for green tea. the tea plant is naturally rich in a group of antioxidants known as catechins. unlike black tea, green tea production involves little processing and fermentation and therefore, g ...200819685436
chromatographic examinations of tea's protection against lipid oxidative modifications.ethanol metabolism is accompanied by generation of free radicals that damage cell components, especially lipids. the present study was designed to investigate the efficacy of the preventive effect of black tea on the lipid oxidative modifications in different tissues (plasma, liver, brain, kidney, stomach, lung, intestine, and spleen) of 12-month-old rats chronically intoxicated with ethanol. ethanol intoxication caused changes in the level/activity of antioxidants that led to the significant in ...200819696910
changes in phospholipid composition studied by hplc and electric properties of liver cell membrane of ethanol-poisoned rats.ethanol introduced into the organism undergoes rapid metabolism to acetaldehyde and then to acetic acid. the process is accompanied by formation of reactive oxygen species (ros), which damage mainly lipids of membrane cells. the effects of ros can be neutralized by administering preparations with antioxidant properties. the natural preparations of this kind are teas.this paper reports data on the effect of green and black tea on the surface charge density, content of phospholipids, and level of ...200819696939
antioxidant activity of some plant extracts towards xanthine oxidase, lipoxygenase and tyrosinase.natural products have the potential to be developed into new drugs for the treatment of various diseases. the aim of the present study was to screen the antioxidant activities of some common edible fruits, garden plants and medicinal plants indigenous to taiwan. this was performed by assessing the activities of lipoxygenase, xanthine oxidase and tyrosinase following incubation with extracts from these plants. a further aim was to use hplc-dad and tyrosinase to chromatographically identify the an ...200919701137
polyphenolic chemistry of tea and coffee: a century of progress.tea and coffee, the most popular beverages in the world, have been consumed for thousands of years for their alluring flavors and health benefits. polyphenols, particularly flavonoids and phenolic acids, are of great abundance in tea and coffee and contribute a lot to their flavor and health properties. this paper reviews the polyphenol chemistry of tea and coffee, specifically their stability, and scavenging ability of reactive oxygen species (ros) and reactive carbonyl species (rcs). during th ...200919719133
black-tea polyphenols suppress postprandial hypertriacylglycerolemia by suppressing lymphatic transport of dietary fat in rats.administration of black-tea polyphenols (btp) at 100 and 200 mg/kg of body weight in rats suppressed postprandial hypertriacylglycerolemia in a dose-dependent manner. administration of btp also suppressed lymphatic recovery of (14)c-trioleoylglycerol in rats that were cannulated in the thoracic duct. btp dose-dependently inhibited the activity of pancreatic lipase in vitro with an ic50 of 0.254 mg/ml. when purified theaflavins, which are components of btp, were used, theaflavins with galloyl moi ...200919722586
comparative flavonoids contents of selected herbs and associations of their radical scavenging activity with antiproliferative actions in v79-4 cells.to elucidate the health benefit of herbal teas on the cytotoxicity induced by h(2)o(2) in v79-4 cells, herbal extracts and its flavonoids were tested using lactate dehydrogenase release and determining intracellular reactive oxygen species generation and antioxidant activity with superoxide radical scavenging assay. significant decrease in cell viability was observed on v79-4 cells treated with h(2)o(2) (1 mm), while herbal extracts and its flavonoids including catechin and epigallocatechin gall ...200919723177
physicochemical properties and antioxidant capacity of 3 polysaccharides from green tea, oolong tea, and black tea.three polysaccharide-rich fractions named gtps, otps, and btps were isolated from green tea, oolong tea, and black tea, respectively. chemical characteristics, glycosidase inhibitory effects, and antioxidant properties of the 3 fractions were compared. monosaccharides of gtps were composed of d-rhamnose, l-arabinose, d-xylose, d-mannose, d-galactose, and d-glucose. but there were no xylose and mannose detected in otps and btps. the molecular weight distributions were decreased from 9.2 to 251.5 ...200919723184
chlorhexidine and green tea extract reduce dentin erosion and abrasion in situ.this in situ/ex vivo study aimed to analyse the impact of possible mmp-inhibitors (chlorhexidine and green tea extract) on dentin wear induced by erosion or erosion plus abrasion.200919733206
an epr study on tea: identification of paramagnetic species, effect of heat and sweeteners.tea (camellia sinensis) is the most widely consumed beverage in the world, and is known to be having therapeutic, antioxidant and nutritional effects. electron paramagnetic resonance (epr) spectral studies made on the tea cultivated along the shore of black sea, turkey, show mn(2+) and fe(3+) centers in green tea leaves and in black tea extract. dry black tea flakes and dry extract show additional sharp line attributed to semiquinone radical. the origins of the paramagnetic species in black tea ...200919733505
a novel ionic liquid/micro-volume back extraction procedure combined with flame atomic absorption spectrometry for determination of trace nickel in samples of nutritional interest.a simple, highly sensitive and environment-friendly method for the determination of trace amount of nickel ion in different matrices is proposed. in the preconcentration step, the nickel from 10 ml of an aqueous solution was extracted into 500 microl of ionic liquid, 1-butyl-3-methylimidazolium hexafluorophosphate [c(4)mim][pf(6)], containing pan as complexing agent. subsequently, the pan complex was back-extracted into 250 microl of nitric acid solution, and 100 microl of it was analyzed by flo ...201019744780
hla-b27 subtypes in patients with spondylarthropathies, ige levels against some allergens and their relationship to the disease parameters.in suitable genetic backgrounds, some exogenous and/or endogenous antigens may cause spa. in this study, we investigated hla b27 subtypes and its relationship to some allergens and clinical findings in a group of spa patients. forty-eight patients (19f, 29m) with spa (27 with ankylosing spondylitis, 5 with reactive arthritis, 15 undifferentiated and 1 with psoriatic arthritis) were included to the study. hla-b alleles have been assessed using the lipa (line probe assay) reverse hybridization pri ...200919750986
green tea (camellia sinensis) catechins and vascular function.the health benefits of green tea (camellia sinensis) catechins are becoming increasingly recognised. amongst the proposed benefits are the maintenance of endothelial function and vascular homeostasis and an associated reduction in atherogenesis and cvd risk. the mounting evidence for the influential effect of green tea catechins on vascular function from epidemiological, human intervention and animal studies is subject to review together with exploration of the potential mechanistic pathways inv ...200919751534
determination of pb2+ ions by a modified carbon paste electrode based on multi-walled carbon nanotubes (mwcnts) and nanosilica.a novel carbon paste ion selective electrode for determination of trace amount of lead was prepared. multi-walled carbon nanotubes (mwcnts) and nanosilica were used for improvement of a lead carbon paste sensor response. mwcnts have a good conductivity which helps the transduction of the signal in carbon paste electrode. the electrode composition of 20 wt% paraffin oil, 57% graphite powder, 15% ionophore (thiram), 5% mwcnts, and 3% nanosilica showed the stable potential response to pb(2+) ions w ...201019758753
l-theanine, an amino acid in green tea, attenuates beta-amyloid-induced cognitive dysfunction and neurotoxicity: reduction in oxidative damage and inactivation of erk/p38 kinase and nf-kappab pathways.amyloid beta (abeta)-induced neurotoxicity is a major pathological mechanism of alzheimer disease (ad). in this study, we investigated the inhibitory effect of l-theanine, a component of green tea (camellia sinensis), on abeta(1-42)-induced neuronal cell death and memory impairment. oral treatment of l-theanine (2 and 4 mg/kg) for 5 weeks in the drinking water of mice, followed by injection of abeta(1-42) (2 microg/mouse, icv), significantly attenuated abeta(1-42)-induced memory impairment. furt ...200919766184
tea consumption and risk of endometrial cancer: a metaanalysis.the objective of the study was to assess the association between tea consumption and endometrial cancer.200919766982
black tea theaflavins extend the lifespan of fruit flies.black tea extract (bte) is a mixture of epicatechins and theaflavins. the present study investigated the effect of bte on the lifespan of drosophila melanogaster. results showed the mean lifespan was significantly extended from 51 to 56days upon bte treatment. gene expression of superoxide dismutase (sod1 and sod2), catalase (cat), and methuselah (mth) was characterized by an increase in young and then a decrease in aged fruit flies. higher gene expression of sod1 and cat was observed in the bte ...200919770032
skin penetration of epigallocatechin-3-gallate and quercetin from green tea and ginkgo biloba extracts vehiculated in cosmetic formulations.green tea (camellia sinensis) and ginkgo biloba extracts in cosmetic formulations have been suggested to protect the skin against uv-induced damage and skin ageing. thus, it is very important to assess the human skin penetration of their major flavonoids to verify if they penetrate and remain in the skin to exert their proposed effects. the aim of this study was to evaluate the human skin penetration of epigallocatechin-3-gallate (egcg) and quercetin from green tea and g. biloba extracts vehicul ...200919786823
the effectiveness of hibiscus sabdariffa in the treatment of hypertension: a systematic review.hypertension is a common global health problem with significant mortality and morbidity. hibiscus sabdariffa is a plant known in many countries and is consumed as hot and cold drinks in addition to its use in folk medicine; it has been suggested as treatment for many conditions including hypertension.201019801187
consumption of coffee, green tea, oolong tea, black tea, chocolate snacks and the caffeine content in relation to risk of diabetes in japanese men and women.although the inverse association between coffee consumption and risk of diabetes has been reported numerous times, the role of caffeine intake in this association has remained unclear. we evaluated the consumption of coffee and other beverages and food containing caffeine in relation to the incidence of diabetes. the study participants were 5897 men and 7643 women in a community-based cohort in takayama, japan. consumption of coffee, green tea, oolong tea, black tea and chocolate snacks were mea ...201019818197
modulatory effects of black v. green tea aqueous extract on hyperglycaemia, hyperlipidaemia and liver dysfunction in diabetic and obese rat models.cardiovascular complications are a major cause of morbidity and mortality in patients with diabetes, obesity and the metabolic syndrome. recently, there has been an increasing interest in tea as a protective agent against cvd. here, we compared the modulatory effects of two different doses (50 and 100 mg/kg body weight given orally for 28 consecutive days) of black tea aqueous extract (bte, rich in theaflavins and thearubigins) and green tea aqueous extract (gte, rich in catechins) on experiment ...200919825205
greeen tea extracts lower serum folates in rats at very high dietary concentrations only and do not affect plasma folates in a human pilot study.green tea catechins (gtc) have been shown to inhibit the activities of enzymes involved in folate uptake. hence, regular green tea drinkers may be at risk of impaired folate status. the present experiments aimed at studying the impact of dietary gtc on folate concentrations and metabolism. in a human pilot study (parallel design) healthy men consumed for 3 weeks 6 capsules (approximately 670 mg gtc) per day (2 capsules with each principal meal) containing aqueous extracts of the leaves of camell ...200919826188
assessment of desiccation sensitivity of tea embryos for cryopreservation.tea (camellia sinensis (l.) o. kuntze) has been reported as a species with recalcitrant seeds. the seeds can be stored for less than one year under high humidity conditions in a refrigerator at 5-7 degrees c. an efficient cryopreservation protocol for tea embryos using embryonic axes with portions of cotyledons still attached as drying material was established, which led to survival percentages around 92%. however, understanding the pattern of desiccation sensitivity, which is the key-limiting f ...200919827256
distribution and biosynthesis of theanine in theaceae plants.the theanine content of the leaves of 27 species or varieties of theaceae plants was investigated. theanine was present in 21 species or varieties, but in much lower amounts (<0.2 mumol/g fresh weight) than the quantity detected in camellia sinensis var. sinensis. the major free amino acids in leaves of four species belonging to the genera schima and eurya, were glutamic acid, aspartic acid, glutamine, asparagine, alanine and proline and content of these amino acids is similar to or higher than ...201019828327
investigation of the site-specific accumulation of catechins in the tea plant (camellia sinensis (l.) o. kuntze) via vanillin-hcl staining.histochemical staining using vanillin-hcl is a potential tool to identify the site-specific accumulation of catechins in the tea plant (camellia sinensis (l.) o. kuntze). using this technique revealed that catechins existed ubiquitously in all inspected tissues in young tea leaf, but the distribution was concentrated in the vascular bundle and palisade tissue, whereas the large parenchyma cells of the main vein contained lower amounts of catechins. at the subcellular level, catechins were locate ...200919831398
prospective double-blind crossover study of camellia sinensis (green tea) in dyslipidemias.epidemiological studies have established an association between dyslipidemias and atherosclerosis. nutritional therapy is a key point in the prevention strategy for individuals who present with risk factors for atherosclerotic disease.200919838489
antimicrobial properties of green tea catechins.extracts of leaves from the tea plant camellia sinensis contain polyphenolic components with activity against a wide spectrum of microbes. studies conducted over the last 20 years have shown that the green tea polyphenolic catechins, in particular (-)-epigallocatechin gallate (egcg) and (-)-epicatechin gallate (ecg), can inhibit the growth of a wide range of gram-positive and gram-negative bacterial species with moderate potency. evidence is emerging that these molecules may be useful in the con ...200519844590
a new myricetin-rhamnodiglucoside from camellia sinensis.the isolation and structural elucidation of the novel myricetin-3-o-[beta-d-glucopyranosyl-(1 --> 3)-alpha-l-rhamnopyranosyl-(1 --> 6)-beta-d-glucopyranoside] from tea (camellia sinensis (l.) o. kuntze) by means of hplc-ms/ms and various nmr techniques is described. the compound was not present in all tea samples analysed. in the case of white tea, it was detected in 20 out of 40 samples analysed (35-255 mg kg(-1)), in green tea it was detected in 18 out of 35 samples in the same concentration r ...200919851929
nutritional supplements and serum lipids: does anything work?hyperlipidemia is a risk factor for the development of coronary heart disease. many patients decline prescription lipid-lowering agents and opt instead for supplements. before any supplement can be routinely recommended it is crucial to examine the types of clinical trials that have been performed, the mechanism by which a supplement is felt to alter lipids, the population studied, potential adverse effects, and the possibility that investigators might be biased. clinical trial evidence strongly ...200919852889
cloning, microbial expression and structure-activity relationship of polyphenol oxidases from camellia sinensis.polyphenol oxidase (ppo) can be used for organic synthesis and degradation of wastes and dyes in industries. lack of enzyme sources is a major barrier for its application. a ppo gene, with a full length of 1.8kb without introns, was cloned by pcr from genomic dna of five common cultivars of camellia sinensis. they had a 98.2-99.9% degree of identity in nucleotides and 94.7-96.1% in amino acids and encoded a polypeptide of 599 amino acids with a signal peptide targeting the chloroplast and three ...201019857531
identification of a major polyphenol and polyphenolic composition in leaves of camellia irrawadiensis.the polyphenolic composition of camellia irrawadiensis, which is a closely related species of camellia sinensis (cultivated tea), was investigated. the most predominant polyphenol, a kind of ellagitannin, was isolated from leaves of c. irrawadiensis. its structure was established as 1,2-di-o-galloyl-4,6-o-(s)-hexahydroxydiphenoyl-beta-d-glucose (2) on the basis of spectral and chemical evidence. moreover, the polyphenols [catechins, strictinin (1), compound 2, theogallin, and gallic acid] and tw ...200919881283
tea, coffee, and cocoa as ultraviolet radiation protectants for the beet armyworm nucleopolyhedrovirus.the addition of 1% (wt:vol) aqueous extracts of cocoa (theobroma cacao l.) (malvales: malvaceae), coffee (coffea arabica l.) (gentianales: rubiaceae), and green and black tea (camellia sinensis l.) (ericales: theaceae) provided excellent uv radiation protection for the beet armyworm, spodoptera exigua (hübner) (lepidoptera: noctuidae), nucleopolyhedrovirus under laboratory conditions. aqueous extracts of coffee, green tea, and black tea at 0.5% provided 85-100% uv protection, whereas cocoa provi ...200919886440
effect of girdling on levels of catechins in fresh leaf in relation to quality of 'huang zhi xiang' oolong' tea.oolong tea is one of the most popular beverages due to the presence of significant amount of catechins. experiments were conducted to investigate the effect of girdling treatment on levels of catechins in fresh tea leaf related to quality of the 'huang zhi xiang' oolong tea (camellia sinensis). the variations in the levels of catechins in fresh tea leaf and the quality score (qs) of the 'huang zhi xiang' oolong tea were examined. the study demonstrated that girdling treatment increased significa ...200919898938
[genetic diversity of camellia sinensis germplasm in guangdong province based on morphological parameters and srap markers].by the methods of phenotypic identification and srap makers amplification, the genetic diversity of twenty-five local tea cultivars in guangdong province and five contrastive cultivars from other regions was assessed and classified, and the phenotypic traits of the cultivars were clustered by pearson correlation and farthest neighbor methods. the coefficient of variation of the phenotypic traits was averagely 32.15%. fine-hair had the highest coefficient of variation (42.41%), while the growth p ...200919899450
computational structural analysis and kinetic studies of a cytosolic glutamine synthetase from camellia sinensis (l.) o. kuntze.structural analysis of a cytosolic glutamine synthetase from camellia sinensis (csgs) has been conducted employing computational techniques. this was conducted to compare its structural aspects with other known structures of gs. the disordered residues and their distribution in csgs are in close comparison to earlier reported gs. the 3-d structure of csgs also showed high degree of similarity with the only known crystal structure of gs from zea mays. the k ( m ) values observed with recombinant ...200919921413
green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet.the mechanisms of how tea and epigallocatechin-3-gallate (egcg) lower body fat are not completely understood. this study investigated long-term administration of green tea (gt), black tea (bt), or isolated egcg (1 mg/kg per day) on body composition, glucose tolerance, and gene expression related to energy metabolism and lipid homeostasis; it was hypothesized that all treatments would improve the indicators of metabolic syndrome. rats were fed a 15% fat diet for 6 months from 4 weeks of age and w ...200919932867
inhibitory effects of tea polyphenols by targeting cyclooxygenase-2 through regulation of nuclear factor kappa b, akt and p53 in rat mammary tumors.breast cancer has become the second leading cause of cancer-related deaths worldwide. the control of this disease can be achieved through chemoprevention, which refers to the consumption of synthetic or naturally occurring agents to block, reverse, or delay the process of tumor development. tea (camellia sinensis), the most widely consumed beverage, has shown promises in the field of cancer chemoprevention. inhibition of tumorigenesis by green or black tea polyphenols has been demonstrated in va ...201119936622
black tea and blood pressure. 200919938231
anthelmintic effects of phytogenic feed additives in ascaris suum inoculated pigs.two experiments were performed to determine the anthelmintic effect of some phytogenic feed additives on a mild infection of ascaris suum in growing and finishing pigs. usually, an infection of a. suum is controlled by using conventional synthetic drugs. organic farmers, however, prefer a non-pharmaceutical approach to worm control. therefore, phytotherapy could be an appropriate alternative. in the first experiment, a commercial available organic starter diet was supplemented with 3% of a herb ...201019954891
fluid intake and the risk of bladder cancer: results from the south and east china case-control study on bladder cancer.although several studies have assessed the association between total fluid intake, specific drinks and bladder cancer, no firm conclusions can yet be drawn. four hundred thirty two bladder cancer cases and 392 frequency matched hospital-based controls recruited in the south and east of china between october 2005 and june 2008 were interviewed on their intake of 6 nonalcoholic and 3 alcoholic drinks. age, sex, smoking and hospital-adjusted odds ratios (or) and 95 percent confidence intervals (95% ...201019957334
black tea reduces uric acid and c-reactive protein levels in humans susceptible to cardiovascular diseases.the effect of black tea on the level of uric acid (ua) and c-reactive proteins (crp) in humans susceptible to ischemic heart diseases was assessed in a prospective randomized controlled study. the study group consumed 9 g of black tea (equivalent to three cups of tea) daily for 12 weeks without additives followed by a 3-week wash-out (with control group consuming equivalent volume of hot water). black tea consumption induced a highly significant decrease in the high uric acid baseline groups > 6 ...201019963031
metabolomics analysis reveals the compositional differences of shade grown tea (camellia sinensis l.).the different cultivation methods affect tea quality by altering the basic metabolite profiles. in this study, the metabolome changes were investigated in green tea and shade cultured green tea (tencha) by liquid chromatography-mass spectrometry (lc-ms) and gas chromatography-mass spectrometry (gc-ms) coupled with a multivariate data set. the principal component analysis (pca) and orthogonal projection to latent structures discriminate analysis (opls-da) of green tea clearly showed higher levels ...201019994861
coffee, green tea, black tea and oolong tea consumption and risk of mortality from cardiovascular disease in japanese men and women.the effects of coffee and green, black and oolong teas and caffeine intake on cardiovascular disease (cvd) mortality have not been well defined in asian countries.201119996359
reaction of the black tea pigment theaflavin during enzymatic oxidation of tea catechins.degradation of the black tea pigment theaflavin was examined in detail. enzymatic oxidation of a mixture of epigallocatechin and epicatechin initially produced theaflavin, while prolonged reaction decreased the product. addition of ethanol to the reaction mixture at the point when theaflavin began to decrease afforded four new products, together with theanaphthoquinone, a known oxidation product of theaflavin. the structures of the new products were determined by spectroscopic methods. one of th ...201020014758
modulatory effects of black tea polyphenols on rat forestomach carcinogenesis.abstract the present study was designed to evaluate the chemopreventive effects of black tea polyphenols (polyphenon-b) on n-methyl-n'-nitro-n-nitrosoguanidine (mnng)-induced gastric carcinogenesis in wistar rats. intragastric administration of mnng induced well-differentiated squamous cell carcinomas that showed diminished mitochondrial lipid and protein oxidation and an increase in antioxidants. in contrast to tumor tissue, the liver mitochondria of tumor-bearing animals showed elevated lipid ...200720020873
protective effect of black tea polyphenols against 7,12-dimethylbenz[a]anthracene-induced genotoxicity and oxidative stress during hamster buccal pouch carcinogenesis.abstract this study was designed to evaluate the protective effect of black tea polyphenols (polyphenon b) against genotoxicity and oxidative stress during 7,12-dimethylbenz[a]anthracene (dmba)-induced hamster buccal pouch (hbp) carcinogenesis. since the bone marrow reflects hematopoietic stress caused by tumor cells, we used the frequency of micronuclei, the extent of lipid peroxidation, and the status of antioxidants in the bone marrow plasma as intermediate biomarkers of oxidative stress. all ...200720020977
comparative safety evaluation of chinese pu-erh green tea extract and pu-erh black tea extract in wistar rats.pu-erh teas are believed to be beneficial beverages for health since they possess several pharmacological properties such as antioxidation, hypocholesterolemia, and antiobesity properties, but their potential toxicities when administered at a high dose as concentrated extracts have not been completely investigated. in this study, the chemical components in pu-erh green tea and pu-erh black tea were analyzed and compared, and the safety of tea extracts was evaluated in wistar rats. the polysaccha ...201020028013
identification, quantitation, and method validation for flavan-3-ols in fermented ready-to-drink teas from the italian market using hplc-uv/dad and lc-ms/ms.the present study is focused on flavan-3-ols characterizing the antioxidant properties of fermented tea (camellia sinensis). these bioactive compounds, object of nutritional claims in commercial products, should be quantified with rigorous analytical procedures whose accuracy and precision have been stated with a certain level of confidence. an hplc-uv/dad method, able to detect and quantify flavan-3-ols in infusions and ready-to-drink teas, has been developed for routine analysis and validated ...200920029906
structural characteristics for superoxide anion radical scavenging and productive activities of green tea polyphenols including proanthocyanidin dimers.the purpose of this paper is to report structural characteristics for superoxide anion radical (o(2(-))) scavenging and productive activities of green tea polyphenols. (-)-epicatechin 3-o-gallate (5), (-)-epigallocatechin (6), (-)-epigallocatechin 3-o-gallate (7), (+)-gallocatechin-(4alpha-->8')-epigallocatechin (8), and (-)-epigallocatechin-(2beta-->o-->7', 4beta-->8')-epicatechin 3'-o-gallate (9) were isolated from the tea plant camellia sinensis l. (+)-epigallocatechin-(2beta-->o-->7, 4beta-- ...201020045974
[effect of broken black tea on the formation of dental enamel and the contents of twelve kinds of chemical elements].objective: the aim of this study was to investigate the effect of broken black tea with slightly hyper-normal fluoride content which was near the level of people tea-drinking habits on enamel morphological structure and its content of chemical elements. thirty six rats were divided randomly into 3 groups: one was control group and another two groups fed with broken black tea infusion with f- content of 8.2 mg/l and 16.4 mg/l, respectively. after 360 days, collected 144 teeth, observed their morp ...200920047234
polyphenols action against oxidative stress formation in endothelial cells.the aim of this study was to investigate the influence of epigallocatechin-3-gallate (egcg), theaflavins (tfs) and black tea extract (bte) on oxidative stress formation as well as on antioxidant system of human vein endothelial cells (huvec). huvec were incubated for 0,5 h with 100 mm tert-butyl hydroperoxide (t-bhp) for oxidative stress formation. the influence of egcg, tfs, and bte on oxidative stress and antioxidant system parameters was investigated by the pre-incubation for 2 h with 50 mg/m ...200920050525
evaluation of different teas against starch digestibility by mammalian glycosidases.current work investigated the ability of different tea (green, oolong and black teas) in inhibiting human salivary alpha-amylase (hsa) and mammalian alpha-glucosidase (agh). the inhibitory profiles were correlated to their major polyphenol content (theaflavins and catechins). the fully fermented black tea was demonstrated to be most potent in inhibiting hsa and agh (ic50 of 0.42 to 0.67 and 0.56 to 0.58 mg of tea leaves/ml respectively). its capability in retarding the digestion of a real food s ...201020050703
seasonal variation of total phenolic, antioxidant activity and minerals in fresh tea shoots (camellia sinensis var. sinensis).seasonal variation of total phenolics, antioxidant activity and minerals in fresh tea shoots, consisting of one apical bud and two adjoining leaves sampled from muradiye, tuglali, gundogdu, enstitu 9, hamzabey, hayrat and pazar 20 clones grown in eastern black sea region in turkey was investigated during three harvest season (may, july and september) in both 2006 and 2007 years. the total phenolics of all clones were lower in cool months of may in both years (average 33.00-90.27 mg gae/g dry wei ...201020067870
polyphenolics profile, antioxidant and radical scavenging activity of leaves and stem of raphanus sativus l.aerial parts (leaves and stem) of raphanus sativus, which are usually discarded were found to possess potent antioxidant and radical scavenging activity, as measured by standard antioxidant assays. methanolic and acetone extracts of r. sativus leaves had total polyphenolic content of 86.16 and 78.77 mg/g dry extract, which were comparable to the traditional rich sources such as green tea and black tea. hplc identification of polyphenolics indicated the presence of catechin, protocatechuic acid, ...201020072818
laboratory, epidemiological, and human intervention studies show that tea (camellia sinensis) may be useful in the prevention of obesity.tea (camellia sinensis, theaceae) and tea polyphenols have been studied for the prevention of chronic diseases, including obesity. obesity currently affects >20% of adults in the united states and is a risk factor for chronic diseases such as type ii diabetes, cardiovascular disease, and cancer. given this increasing public health concern, the use of dietary agents for the prevention of obesity would be of tremendous benefit. whereas many laboratory studies have demonstrated the potential effica ...201020089791
antioxidant potential of tea reduces arsenite induced oxidative stress in swiss albino mice.environmental arsenic (as) is a potent human carcinogen and groundwater as contamination is a major health concern in west bengal, india. oxidative stress has been one of the prime factors in as-induced carcinogenicity. generation of reactive oxygen species (ros), beyond the body's endogenous antioxidant balance cause a severe imbalance of the cellular antioxidant defence mechanism. tea, a popular beverage has excellent chemopreventive and antioxidant properties. in this study it was investigate ...201020096321
increased responsiveness of human coronary artery endothelial cells in inflammation and coagulation.the effects of anti-inflammatory plant extracts, such as black tea extract (bte) and resveratrol (rsv) could modulate cell activation leading to atherosclerosis, however there is little comparative information about how different endothelial cell types are affected by these compounds. in order to compare human endothelial cells derived from different origins (umbilical vein or huvec, coronary artery or hcaec, microvascular or hmvec) and their interleukin-1beta (il-1beta) responsiveness, il-6 eli ...201020107610
addition of whole, semiskimmed, and skimmed bovine milk reduces the total antioxidant capacity of black tea.epidemiological studies have shown that populations consuming fruits, vegetables, tea, cocoa, and red wine have lower incidences of cardiovascular disease, certain cancers, and eye disease. these health effects have largely been attributed to the polyphenol content of the foods and drinks studied. black tea is rich in a range of polyphenolic compounds that could potentially have health-promoting properties. the scale of consumption of tea in the united kingdom means that it could be an appropria ...201020116655
effects of green tea, black tea and rooibos tea on angiotensin-converting enzyme and nitric oxide in healthy volunteers.tea has been reported to reduce cardiovascular mortality, but the underlying mechanisms are largely unknown. the aim of the current project was to investigate the effect of green tea (japanese sencha), black tea (indian assam b.o.p.) and rooibos tea (south africa) on angiotensin-converting enzyme (ace) and nitric oxide (no).201020144258
protective role of tannin-rich fraction of camellia sinensis in tissue arsenic burden in sprague dawley rats.the protective effect of green tea (camellia sinensis) was tested against arsenic-induced toxicity. however, the possible role of tannins in green tea in alleviating hepatic and renal oxidative injury has also been studied. administration of sodium arsenite (100 mg/kg/day) for 28 days in sprague dawley female rats resulted in significant reduction of biochemical parameters such as delta-aminolevulinic acid dehydratase (alad), reduced glutathione (gsh), glutathione peroxidase (gpx), superoxide di ...201020144955
merging traditional chinese medicine with modern drug discovery technologies to find novel drugs and functional foods.traditional chinese medicines (tcm) are rapidly gaining attention in the west as sources of new drugs, dietary supplements and functional foods. however, lack of consistent manufacturing practices and quality standards, fear of adulteration, and perceived deficiencies in scientific validation of efficacy and safety impede worldwide acceptance of tcm. in addition, western pharmaceutical industries and regulatory agencies are partial toward single ingredient drugs based on synthetic molecules, and ...201020156139
chemistry of secondary polyphenols produced during processing of tea and selected foods.this review will discuss recent progress in the chemistry of secondary polyphenols produced during food processing. the production mechanism of the secondary polyphenols in black tea, whisky, cinnamon, and persimmon fruits will be introduced. in the process of black tea production, tea leaf catechins are enzymatically oxidized to yield a complex mixture of oxidation products, including theaflavins and thearubigins. despite the importance of the beverage, most of the chemical constituents have no ...200920161999
the effects of theaflavin-enriched black tea extract on muscle soreness, oxidative stress, inflammation, and endocrine responses to acute anaerobic interval training: a randomized, double-blind, crossover study.muscle soreness and decreased performance often follow a bout of high-intensity exercise. by reducing these effects, an athlete can train more frequently and increase long-term performance. the purpose of this study is to examine whether a high-potency, black tea extract (bte) alters the delayed onset muscle soreness (doms), oxidative stress, inflammation, and cortisol (cort) responses to high-intensity anaerobic exercise.201020178632
the chemistry of low molecular weight black tea polyphenols.this review summarises the chemistry of low molecular weight polyphenols isolated and characterised from black tea, discussing both structures identified and mechanisms of their likely formation.201020179879
on-line hplc method for screening of antioxidants against superoxide anion radical from complex mixtures.a practical approach for rapidly screening antioxidants against superoxide anion radicals from complex mixtures was developed based on the quantitative difference in active compounds before and after their reaction. to test the effectiveness of the approach, seven flavonoids with antioxidative properties were investigated both individually and in a mixture. using the approach, antioxidants could be rapidly separated and screened with a ranked order of activities in the meantime. the radical scav ...201020183820
therapeutic effects on murine oral candidiasis by oral administration of cassia (cinnamomum cassia) preparation.we examined the effects of spices and herbs on candida albicans growth using in vitro assay and therapeutic activity of some selected herbal preparations against murine oral candidiasis. all tested samples: lemongrass (cymbopogon citratus), lemon balm (melissa officinalis), thyme (thymus vulgaris), rosemary (rosmarinus officinalis), roselle (hibiscus sabdariffa), green tea (camellia sinensis), and cassia (cinnamomum cassia) inhibited candida mycelial growth in vitro. the results of this assay sh ...201020185867
effect of ethnomedicinal plants used in folklore medicine in jordan as antibiotic resistant inhibitors on escherichia coli.escherichia coli occurs naturally in the human gut; however, certain strains that can cause infections, are becoming resistant to antibiotics. multidrug-resistant e. coli that produce extended-spectrum beta lactamases (esbls), such as the ctx-m enzymes, have emerged within the community setting as an important cause of urinary tract infections (utis) and bloodstream infections may be associated with these community-onsets. this is the first report testing the antibiotic resistance-modifying acti ...201020187978
distribution and biosynthesis of flavan-3-ols in camellia sinensis seedlings and expression of genes encoding biosynthetic enzymes.the distribution of phenolic compounds in young and developing leaves, stems, main and lateral roots and cotyledons of 8-week-old tea (camellia sinensis) seedlings was investigated using hplc-ms(2). fourteen compounds, flavan-3-ols, chlorogenic acids, and kaempferol-o-glycosides, were identified on the basis of their retention time, absorbance spectrum, and ms fragmentation pattern. the major phenolics were (-)-epigallocatechin-3-o-gallate and (-)-epicatechin-3-o-gallate, located principally in ...201020189205
oxalate content of green tea of different origin, quality, preparation and time of harvest.the purpose of the study was to analyse the oxalate content of green tea (camellia sinensis) depending on origin, quality, time of harvest and preparation. fifty-two green tea samples were received from different regions of china. the oxalate content of each tea infusion was measured using a validated hplc-enzyme-reactor method. the soluble oxalate content of green tea ranged from 8.3 to 139.8 mg/l. in samples from known provenances, the highest oxalate concentration was found in green tea from ...201020204342
a novel cold-regulated gene from camellia sinensis, cscor1, enhances salt- and dehydration-tolerance in tobacco.in present research, the full-length cdna and the genomic sequence of a novel cold-regulated gene, cscor1, were isolated from camellia sinensis l. the deduced protein cscor1 contains a hydrophobic n-terminus as a signal peptide and a hydrophilic c-terminal domain that is rich in glycine, arginine and proline. two internal repetitive tridecapeptide fragments (hsvtagrggynrg) exist in the middle of the c-terminal domain and the two nucleotide sequences encoding them are identical. cscor1 was locali ...201020206599
effects of green tea on iron accumulation and oxidative stress in livers of iron-challenged thalassemic mice.liver is affected by secondary iron overload in transfusions dependent b-thalassemia patients. the redox iron can generate reactive oxidants that damage biomolecules, leading to liver fibrosis and cirrhosis. iron chelators are used to treat thalassemias to achieve negative iron balance and relieve oxidant-induced organ dysfunctions. green tea (gt) (camellia sinensis) catechins exhibit anti-oxidation, the inhibition of carcinogenesis, the detoxification of cyp2e1-catalyzed hepg2 cells and iron ch ...201020218965
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