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intestinal polyps in the nigerian african.intestinal polyps appear to be relatively rare in the african including nigerians, south african bantus, and ugandans. only 40 histologically confirmed cases were encountered over a period of ten years. analysis of these cases reveals a preponderance (60%) of the non-neoplastic juvenile type of polyp. neoplastic polyps were not encountered in any female patient. the mean ages of the patients are much lower than what has been observed in caucasians inhabiting developed and industrialized countrie ...20051150887
unit-dose assay of tropine alkaloids and their synthetic analogs.a charge-transfer spectrophotometric method was developed for unit-dose assay of the tropine alkaloids and some of their synthetic analogs. the high molar absorptivities of the charge-transfer bands of the alkaloids with iodine in ethylene dichloride resulted in improved recoveries and good precision, particularly at the low dose levels of pediatric and hypodermic tablets.20051151716
acetanilides: effects on invertebrate neurons correlated with analgesic activity in vertebrates.identified neurons in the buccal ganglion of the marine mollusc navanax inermis were used to examine the effects of acetanilides on neuronal membrane properties. acetanilides increased the membrane potential and conductance of these neurons in a dose-dependent, reversible manner. these events would have the effect of decreasing membrane excitability. acetanilides increased the slope of the curve of membrane potential as a function of log [k+]o from 33 to 58 mv decade change in [k+]o and decrease ...20051151738
the cardiac pharmacology of tolbutamide.recent clinical studies have suggested an association of tolbutamide therapy with an increased incidence of cardiovascular deaths. due to the paucity of information concerning the acute cardiac actions of tolbutamide, the effects of this agent upon cardiac contractility and automaticity were examined under in vivo and in vitro conditions in rabbit, cat and dog heart muscle preparations. tolbutamide (10(-6) to 3 x 10(-3) m) produced a biphasic inotropic response with a peak positive inotropic res ...19751151754
intracellular recordings of rod responses during dark-adaptation.1. dark-adaptation of rod photoreceptors has been studied in the isolated axolotl (ambystoma mexicanum) retina by intracellular recordings. rod responsiveness was greatly reduced immediately after a 30 sec partial bleach, but partially recovered with time in the dark. 2. in parallel spectrophotometric measurements using isolated retinas, regeneration of the rod pigment could not be detected after a 30 sec bleach. 3. during rod dark-adaptation, the response of a rod to a given stimulus increased ...20051151778
proceedings: the effect of tris on the response of various isolated, mammalian preparations to nerve and drug stimulation. 19751151799
proceedings: slow recovery of the inactivation of sodium conductance in myxicola giant axons. 20051151857
proceedings: effects of histamine, 2-methylhistamine and 4-methylhistamine on blood pressure and vascular resistance in the cat. 19751151865
proceedings: the influence of extracellular potassium ions on the action of ouabain on membrane currents in sheep purkinje fibres. 19751151872
stereospecific synthesis of the 6beta-hydroxy metabolites of naltrexone and naloxone.the narcotic antagonists naltrexone (1a) and naloxone (2a) were stereospecifically reduced to the corresponding 6beta-hydroxy epimers 1b and 2b, respectively, with formamidinesulfinic acid in an aqueous alkaline medium. the reaction products were obtained with no detectable quantity of the 6alpha epimers 1c and 2c. the products 1b and 2b were formed in yields of 88.5 and 40%, respectively, and characterized by spectral methods. compared to 1a and 2a, the stereospecific reduction products 1b and ...20051151958
synthesis of an active hydroxylated glutethimide metabolite and some related analogs with sedative-hypnotic and anticonvulsant properties.two synthetic pathways are described for the preparation of 4-hydroxy-2-ethyl-2-phenylglutarimide (2), an active hydroxylated metabolite of glutethimide (1). fourteen other glutethimide analogs were also synthesized and tested for biological activity. most of the analogs exhibited sedative-hypnotic properties and compound 2 possessed the greatest activity compared to the parent drug. 4-amino-2-ethyl-2-phenylglutarimide and 4-hydroxy-2-ethyl-2-phenylglutaconimide (13) exhibited the greatest poten ...20051151995
serological studies on human plague in southern africa. part i. plague antibody levels in a population during a quiescent and a subsequent active period in an endemic region.yersinia pestis fraction l passive haemagglutination studies on human sera obtained randomly during a plague epidemic showed a 10-fold increase in occurrence of antibodies compared with the results obtained on sera from the same population 11 months earlier during a quiescent phase. the pre-epidemic population antibody rate was lower than that in a comparable population tested simultaneously in another endemic region, where a recrudescence of plague was not experienced during the following year. ...19751154171
[experience from a 30-year study of the stability of the properties of the plague vaccine strain ev in the ussr]. 19751154937
dietary fats and properties of endoplasmic reticulum: i. dietary lipid induced changes in composition of microsomal membranes in liver and gastroduodenal mucosa of rat.rats were fed for four weeks with different lipid diets to determine the effects on the endoplasmic reticulum membranes of the liver and on the postmitochondrial supernatant fraction of the gastroduodenal mucosa. the diets contained cholesterol, cacao butter, olive oil, and these in combination. the results showed that dietary lipids were able to modify the composition of the hepatic endoplasmic reticulum and, to a lesser extent, that of postmitochondrial fraction of gastroduodenal mucosa. cacao ...19751160521
comparative morphology of genital cones of genus ancylostoma dubini, 1843.male worms of ancylostoma braziliense, a. ceylanicum, a. kusimaense, a. malayanum, a. duodenale, a. caninum, a. tubaeforme, agriostomum vryburgi and cyclodontostomum purvisi have the external appendages beside the anogenital aperture. these anogenital structures are morphologically similar and are assumed to be homologous among the species with three pairs of teeth or more. in hookworms with two pairs of teeth, the anogenital structures are complex. anogenital features can be used as a taxonomic ...19751166351
hyperplasia in chinese hamster livers after chronic hepatic beta-irradiation. 20051166578
pmr relaxation times of micelles of the nonionic surfactant triton x-100 and mixed micelles with phospholipids.previous pmr studies at 220 mhz have led to the suggestion that phosphatidylcholine and the nonionic surfactant trition-x-100 form mixed micellar structures at high molar ratios of trition to phosphalipid. these mixed micelles provide one form of the phospholipid which the enzyme phospholipase a2 can utilize as substrate. spin-lattice relaxation times (t1) and spin-spin relaxation times (t2) obtained from line widths for resolvable protons in triton x-100 micelles and mixed micelles with egg pho ...20051168549
live mumps vaccine. 20051168562
development of corneal transparency in embryonic chick: influence of exogenous thyroxine and thiouracil on structure, water and electrolyte content. 20051168599
long-term effects of vasectomy on pituitary-gonadal function in man.plasma concentrations of testosterone (t), follicle stimulating hormone (fsh), and luteinizing hormone (lh) and percent binding of t to plasma protein (tb) were studied in 16 normal fertile men and in 81 men who had undergone vasectomy from 1 to 5 yr earlier. no significant difference from the control values to t = 582 plus or minus 39.5 (se) ng/100 ml; fsh = 15.09 plus or minus 2.18 (se) miu/ml; lh =10.03 plus or minus 1.13 (se) miu/ml and tb = 92.99 plus or minus 0.285 (se) % binding was detec ...19751168657
[obstructive cardiomyopathy. a new surgical method of treatment].a case of treatment of obstructive cardiomyopathy by insertion of a disc mistral prosthesis (cooley's technique) is reported. the result obtained was satisfactory from a clinical, haemodynamic and angiocardiographic standpoint. the mode of action of this technique is discussed.20051168899
[litter effect on fetal toxicity test]. 19751169531
[quantitative study on the demand for medical care in rural areas]. 20051169535
secondary hyperparathyroidism. conservative management in patients with renal insufficiency.in three patients with advanced renal disease (inulin clearance, 4.6 to 9.1 ml/min) and systemic manifestations of secondary hyperparathyroidism, concentrations of serum calcium and phosphorus were maintained within our normal limits (9 and 3.5 mg/100 ml, respectively) with phosphate-binding antacids and orally given calcium carbonate. the result was progressive disappearance of symptoms related to secondary hyperparathyroidism, healing of osteitis fibrosa, and normalization of serum concentrati ...20051173103
[some aspects in the prevention of injuries in modern coal mines of the southern urals]. 20051176013
cyclic kinetics and mathematical expression of the primary immune response to soluble antigen. vi. the possibility of prediction of plasma cell reaction in the spleen of mice immunized with soluble antigen.a mathematical expression of the accumulation of the plasma cells in the spleen of cba mice immunized intraperitoneally is presented. the dependence of the plasma cell reaction in the spleen on the kinetics of antigen concentration in the blood was confirmed. for the transition from antigen to plasma cells, index a was proposed. the mean values of index a were used for comparison of the calculated and experimental values of the plasma cell reaction and the recorded differences were not great. in ...19751176044
methionine transport in yersinia pestis.yersinia pestis tjw, an avirulent wild-type strain, requires phenylalanine and methionine for growth. it was of interest to examine and define the methionine transport system because of this requirement. the methionine system showed saturation kinetics with a km for transport of approximately 9 times 10(-7) m. after 8 s of methionine transport, essentially all of the methionine label appeared in s-adenosyl-l-methionine (sam) as detected in ethanol extracts. small amounts of free methionine was d ...19751176434
[effects of isosorbide dinitrate of prolonged action on the prevention of myocardial ischemia induced by exercise: correlation with nitrate blood levels]. 20051180718
a syndrome of acute zinc loss. cerebellar dysfunction, mental changes, anorexia, and taste and smell dysfunction.oral administration of the amino acid histidine to six patients with progressive systemic sclerosis produced anorexia, taste ans smell dysfunction, changes in mentation, and cerebellar dysfunction in each patient; these changes were associated with significant decreases in serum zinc concentration and significant increases in urinary zinc excretion. administration of zinc ion, even with continued histidine administration, returned each of the signs and symptoms to or toward normal within 8 to 24 ...20051180744
cervicocranium and the aviator's protective helmet.an analogy based on the likenesses of the aph-6 aviator's protective helmet and the hangman's noose has some interesting relationships to aircraft accident investigation and to the associated traumatic pathology. a superficial examination of the similarities might propose that the inferior edge of the helmet, when considered part of the continuous circle completed by the nape strap and the chin strap, forms a loop which can be likened to a hangman's noose. the analogy might be extended to the co ...20051180788
lithium intoxication: a report of two cases.two cases of toxic reaction to lithium carbonate are reported. the first patient displayed symptoms resembling those of organic brain syndrome which was not associated with a high serum lithium level. the influence of diuretic therapy in combination with lithium is felt to enhance the risk of intoxication. the second case depicts acute cns toxicity with known fatal potential. conservative lithium administration is recommended for acute manic psychosis and reference is made to the beneficial effe ...20051182639
xeromammography at a community hospital. a year's experience. 20051183210
surgery and sclerotherapy in the treatment of varicose veins. 20051183211
[letter: adverse effects of antiepileptic drugs]. 20051183340
sex and the otolaryngologist. 20051183564
a study of viral fever in the city of madras. 19751184536
plague and the gallium scan: case report.inflammation in the right axillary lymph nodes and the meninges was detected by 67gacitrate scans in an 11-year-old boy with yersinia pestis infection. this case provides another example of 67ga localizing to areas of infection, indicating potential utility in future cases of bubonic plague.19751185264
individual differences in game motivation as moderators of preprogrammed strategy effects in prisoner's dilemma.the impact of three programmed strategies (tit-for-tat, 100% cooperation, and 100% defection) on cooperation level in the prisoner's dilemma game is examined as a function of the subject's motivational orientation (cooperative, competitive, or individualistic). motivational orientation was assessed on the basis of each subject's choices across four classes of decomposed games. following this assessment, subject's played 30 trials of prisoner's dilemma in matrix form against one of the above-ment ...20051185519
[production of tropane alkaloids in tissue cultures (author's transl)]. 20051187871
[effect of chronic irradiation in low doses on age-related changes in the radiation-resistance of white mice]. 20051188055
[development of clinical nuclear medicine]. 20051193525
electrospinogram and spinal and cortical evoked potentials in experimental spinal cord trauma.studies in 28 traumatized cats showed the following acute changes after spinal cord compression in the cord segment below the trauma: 1) increase in size of the spinal cord evoked potential; 2) increase in size of the electrospinogram; and 3) increase in frequency of the electrospinogram.19751194940
brain 2-phenylethylamine as a major mediator for the central actions of amphetamine and methylphenidate. 19751196013
biochemical aspects of the adaptation of hemoglobin-oxygen affinity of eels to hypoxia. 20051196014
[pre- and postoperative radiotherapy of laryngeal cancer]. 20051196026
[medical radioisotope scintigraphy (physico-technical methods and means of collection of information)]. 20051196037
[use of cf252 for treatment of malignant skin neoplasms]. 20051196042
what's your diagnosis? 20051196062
[treatment of ulcers and necrosis]. 20051196078
[morphology of the hemolytic-uremic syndrome]. 20051196095
synchronization of the fission yeast schizosaccharomyces pombe using heat shocks. 19751196141
a volumetric assessment of pollen levels in the air of ann arbor, michigan. 20051196148
germ cell tumors of the central nervous system: a case report and review of literature. 20051196149
phloroglucinol derivatives of eleven dryopteris species from japan. 20051197418
[vagotomy in corrective operations after stomach resection (author's transl)]. 20051197808
[use of the brock punch for confection of a shunt between both ventricles, the ventricle and pulmonary artery or aorta without cardiopulmonary by-pass (cpb) (author's transl)].use of the brock punch for placing a graft on the ventricle is a simple and easy technique not requiring cpb. this offers large experimental possibilities with clinical applications resulting from the experience gained in the laboratory.19751199652
the functional consequences of colectomy.the colon plays a decisive role in salt and water conservation in the intact human, normally removing from the terminal intestine approximately one liter of isotonic fluid that escapes small bowel absorption. the primary purpose of this colon function is probably to prevent extracellular fluid volume depletion and only incidentally to produce a normal solid stool. the patient with an ileostomy can partly adapt to replace the absorptive capacity lost after colectomy but is still vulnerable if sal ...19751200267
[serotonin in complex treatment of uterine and ovarian neoplasms]. 20051200305
contact urticaria from cephalosporins.a rare instance of contact-type urticaria resulting from an acquired sensitization to cephalosporin compounds in a chemist is reported. patch tests elicited an immediate urticarial rather than a delayed contact-type response. similar control tests to other antibiotics gave negative results. although the patient's primary complaint was urticaria, prolonged or excessive contact with the cephalosporins caused coryza and dyspnea. following transfer to another laboratory where the patient worked with ...20041200667
peripheral gangrene in hypernatraemic dehydration of infancy.gangrene of the extremities complicating diarrhoea and severe hypernatraemic dehydration occurred in 6 infants. this is a rare complication of gastroenteritis, and its association with hypernatraemia does not seem to have previously been emphasized. the increased blood viscosity resulting from serum hyperosmolarity may have been responsible for the gangrene, and studies in our patients suggested that disseminated intravascular coagulation was present. in addition to fluid and electrolyte replace ...20041200677
comparative study on the 3h-thymidine index of dorsal epidermis, buccal mucosa, and seminal vesicles in senile male rats.to supplement previous investigations on endogenous fluctuations of dna synthesis in male rat dorsal epidermis, buccal mucosa and seminal vesicle epithelium from birth to sexual maturity, the labelling indices (l.i.) of these tissues in senile male rats from the same breed, studied under analogous experimental conditions, were evaluated as well as compared to the data obtained from rats in puberal and early mature age. in the dorsal epidermis and buccal mucosa of the old animals the medium l.i. ...19751200711
proceedings: anaesthetics in porphyria: intravenous induction agents. 19751201181
proceedings: further immunological investigations in patients with possible halothane hepatitis. 20051201183
median rhomboid glossitis. candidiasis and not a developmental anomaly.infection by candida albicans was found in all biopsies taken from ten patients presenting with midline lesions of the tongue which clinically presented as median rhomboid glossitis.19751201190
binding of vitamin b12--rat transcobalamin ii and free vitamin b12 to plasma membranes isolated from rat liver.when dialysed rat serum which contains a single, low molecular weight binder for vitamin b12, rat transcobalamin ii (rat tc-ii), was labelled in vitro with 57co-vitamin b12 and then incubated at 30 degrees c (ph 7-5) with vesicles of highly purified plasma membranes separated from microsomal fractions of rat liver by density gradient centrifugation, the 57co-vitamin b12-rat tc-ii complex bound to high affinity sites on the vesicles via a specific (binding after correction for 'non-specific' bind ...19751201244
new inhibitors of methane production by rumen micro-organisms. experiments with animals and other practical possibilities.1. two inhibitors of rumen methane production were given to sheep and their effects were measured using an in vitro technique. 2. the substances used were trichloroethyl pivalate (tce-p) and trichloroethyl adipate (tce-a). in one experiment with two sheep tce-p was injected into the rumen and in another experiment with two sheep the same inhibitor was mixed with the food just before feeding. in another experiment, tce-a was given to two sheep at two dose levels, and in an experiment with four sh ...19751201268
polypectate digestion by yersinia.the ability of yersinia to digest polypectate may be of some value in differentiating y. enterocolitica and y. pseudotuberculosis from some of the other fermenting gram-negative bacilli, such as enterobacter agglomerans, with which they can be confused. pectolytic activity in yersinia may also have some teleologic or taxonomic significance about which we do not care to speculate.19751206110
[sensitivity of inbred mice to the causative agent of plague]. 19751210890
[variety of effects of vitamins on yeast cells in aerobic conditions].the effect of thiamine and biotin on the processes of cell division, assimilation of glucose, and accumulation of the biomass and nitrogen in the cells was studied with the candida yeast. the action of the vitamins depended on the source of nitrogen. in some strains, asparagine can substitute for biotin. biotin has different effect on the production of gamma-aminobutyric acid in candida pulcherrima, c. guilliermondii. c. tropicalis k3-10. high concentrations of arginine were found in c. guillie ...19751214604
[electron microscopic study of double infection induced by potato virus x and potato virus y in nicotiana glutinosa]. 19751214639
editorial: the big or the little operation? 20051214679
stroke rehabilitation. part i. general considerations. 20051214691
[skin diseases caused by cocci]. 20051214698
age at first coitus and choice of contraceptive method: preliminary report on a study of factors related to cervical neoplasia.the incidence of cancer of the uterine cervix appears to be species-specific, thus confounding extrapolation of results from studies with experimental animals. in humans, the incidence varies more by social groups than does any other primary cancer. in a recent study, puerto ricans were found to have a 25 times higher risk of cervical cancer than jews. blacks had 4 times the risk of non-jewish caucasians. age at 1st coitus (afc) and number of coital partners have been related to increased risks. ...19561216007
[resection-endoprosthesis of the proximal humerus (indications and review of 37 cases)]. 19971218468
[effect of the prolonged contact of a flea population with plague bacteria on the infective activity of vetors].results of the experimental infection of fleas (x. cheopis) with the plague agent after their long (2.5 years, 19 generations) feeding on infected white mice showed no difference in the infection activity of these insects as compared to control ones. the authors question the hypothesis according to which a low frequency of protein-formation in some species of fleas is due to their long contact with the plague agent in the historical past.19751221343
[cruveilhier-baumgarten syndrome]. 20031223521
[data on the chemical composition of the fatty oil from plantago seeds]. 20041224055
[functional disorders of the hip joint and their treatment]. 20051224677
[isolation and properties of several auxotrophic mutants of a highly virulent strain of the plague microbe].2432 stable auxotrophic mutants were selected from high virulent yersinia pestis strain 20b after treatment with nitroso guanidine. they were deficient in amino acids (arginine, aspartic acid, citrulline, glycine, glutamic acid, histidine, isoleucine, serine, leucine, lysine, ornithine, proline, tryptophan, tyrosine, valiney, pyrimidine and vitamins (riboflavin, thyamine, nicotinamide). some mutants were two- and three-fold dependent. the leucine-, histidine-, purine-dependent mutants were isola ...19751225753
[optokinetic examination in the school-age child. a: frequency, amplitude, and rhythm]. 20051230901
[bialatan in eye infections]. 20051230935
[epidemic haemorrhagic conjunctivitis in the middle east]. 20051230937
[blindness in syria and the development of its causes since 1950]. 20051230942
[a case of operated dumping syndrome]. 20051230970
the role of the surrounding tissue in the propagation of waves through the arterial system.a theoretical analysis of the flow in arteries is presented, taking into consideration the role played by the surrounding tissues in determining the speed of propagatoion and the damping of the blood pressure pulse. this study was undertaken (a) to exhibit a method of computing the flow properties with a more nearly accurate model, (b) to see if the displacement on the skin would be related to the arterial wall displacement, and hence to pressure, velocity and flow rate of blood in the artery, a ...20051231056
[metabolism of serotonin and histamine in vasomotor rhinitis under the effect of cryotherapy]. 20051231128
[sudden infant death in staphylococcal larynogotracheitis]. 20051231137
[drug pulverizer with a spatula]. 20051231142
[combined air tumor of the larynx]. 20051231145
[isolation and properties of several auxotrophic mutants of a highly virulent strain of the plague microbe].2432 stable auxotrophic mutants were selected from high virulent yersinia pestis strain 20b after treatment with nitroso guanidine. they were deficient in amino acids (arginine, aspartic acid, citrulline, glycine, glutamic acid, histidine, isoleucine, serine, leucine, lysine, ornithine, proline, tryptophan, tyrosine, valine), pyrimidine and vitamins (riboflavin, thyamine, nicotinamide). some mutants were two- and three-fold dependent. the leucine-, histidine-, purine-dependent mutants were isola ...19751232031
[supply of trace elements to ruminants in the german democratic republic. 3. supply of zinc].the supply of zinc to ruminants as influenced by and depending upon the geological origin of soils was investigated using the hair test and the technique of indicator plants. a total of 1276 samples of red meadow clover and 3022 samples of red field clover and 4184 hair specimens from cows were analyzed. the following statistically well-established results were obtained which appear to be generalizable: red meadow clover contained significantly more zn than red field clover (48 ppm/38 ppm). red ...20051233952
absorption of enteric and non-enteric coated prednisolone tablets.1. relative rates of absorption of enteric and non-enteric preparations of prednisolone were measured in five renal transplant recipients. 2. the absorption of the enteric coated preparation is delayed and the peak plasma concentration is much lower than that attained using the same dose of the uncoated material. 3. the therapeutic implications of these observations are discussed.20051233990
the plasma half-life of antipyrine in chromic uraemic and normal subjects.1. antipyrine was given intravenously in a dose of 18 mg/kg body weight to twelve patients with chronic renal failure (plasma creatinine greater than 4.9 mg/100 ml) who were not taking drugs and twenty normal subjects. 2. plasma antipyrine levels were measured by a specific method, the plasma half-life of the drug was determined and used as an index of drug oxidation. 3. the mean (+/- s.d) plasma antipyrine half-life in patients with chronic renal failure (7.3 +/- 2.0 h) was significantly shorte ...20051233993
similar combining sites of igg1 and igg2a antibodies in individual mice as judged from affinity and rate constant measurements.within individual sera, mouse igg1 and igg2a subclass antibodies against the antigenic determinant oligo-d-alanine are likely to have similar combining sites. the antibodies are characterized by two methods, by their rate of binding to antigen equipped sheep red blood cells and by the hapten inhibition of antigen binding. the two characteristics are shown to be independent. the subclass antibodies of thirteen different sera differ by a factor of about 10 in their rate constant and by a factor of ...19751234045
a network theory of the immune system.the fact that every antibody also has antigenic properties leads to the existence of a functional network of interacting antibodies and lymphocytes in the immune system. with a minimum set of assumptions about the nature of these interactions some of the principal features of the immune response such as normal primary and secondary response, low and high zone tolerance induction, and memory can be reproduced. the low zone tolerance phenomenon plays a central role in our theory, as it is the simp ...20051234059
modifications to improve the reliability of the coulter 's'. 20051236633
[effect of certain medico-social factors on work capacity of women who had myocardial infarct]. 20051236646
[traumatic cataract and intra-ocular lens]. 20051236649
cat bite transmission of yersinia pestis infection to man.the transmission of bubonic plague from the kitten of a domestic cat to a man by means of a bite on a finger is described. the human case was complicated by the development of a secondary meningitis, followed, after specific therapy, by protracted recovery. the kitten showed swollen lymph nodes of the head and neck, frothing at the mouth and nostrils, and signs of an acute infectious disease which had a fatal termination. yersinia pestis was isolated on about the 8th day from the cerebrospinal f ...19751238568
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