Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| human papillomavirus type 16 expression in cervical keratinocytes: role of progesterone and glucocorticoid hormones. | to determine the role of the steroid hormones, progesterone and glucocorticoids, and the viral hormone response elements, in the episomal expression of human papillomavirus (hpv) type 16 in primary human ectocervical cells. | 1993 | 8380104 |
| penile intraepithelial neoplasia in patients examined for exposure to human papilloma virus. | female genital malignancies have recently been associated with infection with various types of human papilloma virus. we present 9 cases of penile intraepithelial neoplasia found in men examined for exposure to human papilloma virus. six of these men had acetowhite lesions and underwent biopsies to confirm the potential presence of condylomata acuminata. the remaining 3 patients had lesions that were visible but whose nature was in doubt. in addition to condylomata acuminata, penile intraepithel ... | 1993 | 8380511 |
| correlation between hpv positivity and state of the p53 gene in cervical carcinoma cell lines. | human papillomavirus (hpv) infection is clearly associated with cervical carcinomas, yet it is also true that there are cervical carcinomas in which hpv dna is absent. we examined eight established cell lines derived from cervical carcinomas for the presence of mutations of the p53 antioncogene in relation to the presence of hpv dna sequences. of these eight cell lines, seven were positive for hpv dna and the remaining one was negative for hpv dna. single-strand conformation polymorphism analyse ... | 1993 | 8380785 |
| human papillomavirus dna in distant metastases of cervical cancer. | eighteen distant metastases from cervical cancer to the extrapelvic abdomen, extraabdominal lymph nodes, vulva, suburethral region, skin, and breast in 17 patients were analyzed by southern blot hybridization under nonstringent and stringent conditions for the prevalence of human papillomavirus (hpv) type 11, 16, 18, 31, 33, and 35 dna. fourteen metastases in thirteen patients were hpv-positive. thirteen tumors contained hpv-16 and one hpv-related sequences with varying copy number. in 9 of 11 c ... | 1993 | 8380788 |
| hpv16 e7 protein associates with the protein kinase p33cdk2 and cyclin a. | e7 is the major transforming protein of human papillomavirus type 16 (hpv16). it has been found to associate with the retinoblastoma protein rb1. we investigated whether hpv16 e7 protein was associated with other cellular proteins, in particular with those involved in cell cycle control. immunoprecipitates from caski cell extracts with an anti e7 monoclonal antibody contained a histone h1 kinase. recombinant e7, synthesized in yeast, when mixed with protein extracts from epithelial cells bound h ... | 1993 | 8380917 |
| retinoic acid inhibition of human papillomavirus type 16-mediated transformation of human keratinocytes. | we previously reported that human keratinocytes (hkc) immortalized by transfection with human papillomavirus type 16 dna (hkc/hpv16) are more sensitive than normal hkc to growth inhibition by retinoic acid (ra), and that ra treatment of hkc/hpv16 inhibits hpv16 e6/e7 mrna expression (l. pirisi et al., cancer res., 52: 187-193, 1992). we now demonstrate that hpv16 e2 and e5 mrnas are also decreased by ra treatment of hkc/hpv16, indicating a general inhibition by ra on the expression of hpv16 earl ... | 1993 | 8381332 |
| immunoelectron microscopical localization of human papillomavirus type 16 l1 and e4 proteins in cervical keratinocytes cultured in vivo. | the human papillomavirus (hpv) causes warts, but is also associated with the development of squamous cell dysplasia and carcinoma. the virus is host and tissue specific and the numerous hpv types show predilection for different body sites. experimental production of hpv 16 particles is at present only possible using in vivo culture of keratinocytes containing episomal viral dna. using immunoelectron microscopy, we have investigated the localization of hpv 16 e4 and l1 proteins in a keratinized e ... | 1993 | 8381449 |
| antibodies against papillomavirus antigens in cervical secretions from condyloma patients. | samples of cervical secretions and serum from 30 women with genital condylomas and 30 age-matched controls were tested for the presence of immunoglobulin a (iga) and igg antibodies against a panel of papillomavirus-derived antigens. the same cervical samples were also analyzed for presence of human papillomavirus (hpv) dna by southern blotting and polymerase chain reaction. by southern blotting hpv dna was detected in 8 of 30 patients with condylomas and 2 of 30 controls, and by the polymerase c ... | 1993 | 8381807 |
| serological response to hpv 16 in cervical dysplasia and neoplasia: correlation of antibodies to e6 with cervical cancer. | sera from patients with cervical cancer, cervical intraepithelial neoplasia (cin) and non-genital cancers, and from healthy individuals, were investigated for antibodies to human papilloma virus (hpv) early proteins e4, e6 and e7 and the major capsid protein li by western blot analysis of recombinant hpv proteins. there was a significantly higher prevalence of sera with antibodies to e6 in cervical cancer patients than in healthy individuals or in cin or non-genital-cancer patients. antibodies t ... | 1993 | 8382193 |
| genetic analysis of in vitro progression of human papillomavirus-transfected human cervical cells. | the authors have established an in vitro model system which demonstrates the progression of the transformed phenotypes of human cervical epithelial cells transfected with human papillomavirus (hpv) type 16 and 18 dnas. both viral dnas exhibit immortalizing potential; however, only hpv 18-immortalized cell lines progress to exhibit anchorage-independent growth and, in a limited number of cases, tumorigenesis. in this paper, the authors have examined the genetic basis for this in vitro progression ... | 1993 | 8382557 |
| comparison between methods for human papillomavirus dna testing: a model for self-testing in young women. | this study examined the accuracy of samples obtained by women with dacron swabs for testing for human papillomavirus (hpv). a total of 114 women obtained samples with the swabs and then had routine pelvic examinations done by nurse practitioners during which endocervical and exocervical samples were obtained by speculum-assisted technique. these samples were used for hpv dna testing and cytology. the results of both sets of samples were compared. a total of 104 samples (91%) obtained by self-sam ... | 1993 | 8382720 |
| oral cancer and human papillomaviruses: is there a link? | cancer of the oral cavity accounts for almost 56,000 new cases in india each year totalling almost 30% of all cancer cases in the country. despite the numerous advances in etiology and epidemiology, the mechanisms involved in oral carcinogenesis remain obscure. current research has provided some provocative results, suggesting an association between human papillomavirus (hpv) and development of squamous cell tumors including oral cancer. evidence has been presented showing hpv infection of the o ... | 1993 | 8382758 |
| genital hpv infection not a local but a regional infection: experience from a female teenage group. | to investigate the prevalence of human papillomavirus (hpv) infections in a group of female teenagers, and to analyse to what extent hpv dna was also detectable, in urethra and cervix samples among the patients with macroscopic genital warts compared with those without. | 1993 | 8383095 |
| intramuscular beta-interferon treatment for severe vulvar vestibulitis. | seven patients with vulvar vestibulitis associated with human papillomavirus (hpv) infection were treated with intramuscular (im) injections of human beta-interferon. the im route was chosen to avoid painful intralesional injections. complete remission of symptoms was achieved in three patients who received 45 x 10(6) iu of beta-interferon; they remained asymptomatic for a duration of 6-18 months following treatment. of the four patients who received only 30 x 10(6) iu, two had complete remissio ... | 1993 | 8383204 |
| development of type-specific and cross-reactive serological probes for the minor capsid protein of human papillomavirus type 33. | human papillomavirus type 33 (hpv33) is associated with malignant tumors of the cervix. in an attempt to develop immunological probes for hpv33 infections, antisera against various bacterial fusion proteins carrying sequences of the minor capsid protein encoded by l2 were raised in animals. antigenic determinants on the hpv33 l2 protein were identified by using truncated fusion proteins and were classified as type specific or cross-reactive with respect to hpv1, -8, -11, -16, and -18. cross-reac ... | 1993 | 8383218 |
| cervical neoplasia. its association with human papillomavirus infection. | almost 70 human papillomavirus (hpv) types have been identified. an estimated one-third are anogenital associated. their presence in the genital tract is associated with cancer, and certain particular types have a high correlation with cervical intraepithelial neoplasia (cin) and carcinoma. although a spectrum of histopathologic features within the epithelium characterize changes caused by hpv infection, only dna analysis accurately detects and determines the type of infection. the variety of mo ... | 1993 | 8384240 |
| re: detection of human papillomavirus in squamous neoplasm of the penis. | 1993 | 8384274 | |
| detection of human papillomavirus (hpv) dna in human prostatic tissues by polymerase chain reaction (pcr). | human papillomavirus (hpv) infections are strongly linked to the pathogenesis of uterine cervical neoplasms, and have been implicated in other cancers of the female genital tract. in contrast, the association of hpv with the cancers of the male urogenital tract is less evident, except in anal and penile cancers. however, recent studies reporting the prevalence of hpv infections in human prostate cancers (60-100% hpv 16 positive vs. no infection of hpv) have raised controversies regarding the pre ... | 1993 | 8384363 |
| carcinomas of bartholin's gland. histogenesis and the etiological role of human papillomavirus. | in this study, we examine 10 primary carcinomas of bartholin's gland, including seven squamous carcinomas, two adenoid cystic carcinomas, and one adenocarcinoma, as well as four non-neoplastic bartholin's gland. six of seven squamous cell carcinomas contained human papillomavirus (hpv) type 16 dna detectable by the polymerase chain reaction; one of these demonstrated hpv type 16 by in situ hybridization. the two adenoid cystic carcinomas, the adenocarcinoma, and the non-neoplastic bartholin's gl ... | 1993 | 8384409 |
| detection and typing of human papillomavirus dna in the uterine cervix of japanese women by nonradioactive dot blot and southern blot hybridization. | hpv infection was examined with cytobrush in exfoliated cervical cells sampled from 347 women. hpv dna analysis was conducted in two steps. the presence of hpv dna was demonstrated by dot blotting and typing of hpv dna was made by southern blotting using biotinylated probes. of 167 cases with cervical intra-epithelial neoplasia (cin) and cervical carcinoma, hpv dna was detected and typed in 25 cases (15.0%). hpv 16, 18, and 33 were found mainly, and no hpv 6 or 11 was detected. the frequency of ... | 1993 | 8384546 |
| detection of human papillomavirus 16 and 18 dna in epithelial lesions of the lower genital tract by in situ hybridization and polymerase chain reaction: cervical scrapes are not substitutes for biopsies. | human papillomavirus (hpv) types 16 and 18 in 66 women with histologically documented lesions of the genital tract and 64 control cohorts were investigated. the efficacies of in situ hybridization and polymerase chain reaction (pcr) in detecting hpv 16 and 18 dna were analyzed. in order to assess the usefulness of replacing biopsies with cervical scrapes, the two samples were compared by pcr. the prevalence rates of hpv infection by pcr were 59.1 and 10.9% in patients and controls, respectively. ... | 1993 | 8385153 |
| rapid preparation of tissue dna from paraffin-embedded blocks and analysis by polymerase chain reaction. | we have developed a new, easy, and more rapid method for dna preparation, which avoids contamination. with this method, manual surgical blade scrapings from precisely targeted areas of paraffin block surfaces, without microtome cutting, were used to obtain tissues from 10 different neoplasms. our results indicate the feasibility of dna extraction from the scraped paraffin tissue for molecular genetic analysis. we applied this technique successfully to screen for the presence of human papillomavi ... | 1993 | 8385683 |
| common warts from immunocompetent patients show the same distribution of human papillomavirus types as common warts from immunocompromised patients. | we studied the papillomaviruses (hpv) found in 131 common warts from 111 immunocompetent patients by amplification of viral dna sequences with the general-primer-mediated polymerase chain reaction (pcr). the virus types were determined by restriction-enzyme cleavage and reverse-blot analysis. results were confirmed by using the southern blot technique. forty patients harboured hpv 2a, 25 individuals showed hpv 2c and 13 yielded hpv 57. common warts from 16 patients were induced by a variant of h ... | 1993 | 8385983 |
| varied clinical morphology of hpv-1-induced warts, depending on anatomical factors. | the clinical and histological features of 49 lesions induced by human papillomavirus type 1 (hpv-1) were studied. the majority of cases showed the typical clinical features and location of such lesions. they were usually located on the ventral or lateral surfaces of the hands or feet, and were dome-shaped lesions with a central depression. however, hpv-1-induced lesions located on other body areas displayed different clinical features, such as those of common warts, a digitate wart, and a cutane ... | 1993 | 8385984 |
| expression of the different viral mrnas of human papilloma virus 6 in a squamous-cell carcinoma of the bladder and the cervix. | the prevalence of hpv6 and hpv11 in benign condylomata or mild dysplasias has led to the view of hpv6/11 as rather harmless viruses in relation to carcinogenesis. however, the detection of hpv6/11 dna in a number of individual cases of squamous-cell carcinomas of the anogenital/urinary tract could also point to a possible contribution of these viruses in the development of certain malignancies. recently we have shown that the transcription of the e6 and e7 genes of hpv6 in benign anogenital cond ... | 1993 | 8386138 |
| the discrimination of high-risk hpv types by in situ hybridization and the polymerase chain reaction. | the parameter tmt has been defined by non-isotopic in situ hybridization and describes the tissue melting temperature (tmt) of human papillomavirus (hpv) dna sequences. in this study, multiple in situ hybridization signals for hpv types 16, 31 and 33 in individual archival biopsies hybridized with genomic probes are shown by polymerase chain reactions to be due to cross-hybridization of probe sequences to a single tissue target. tmt is independent of viral type but depends on the homology betwee ... | 1993 | 8386149 |
| [correlation between chronic hyperplastic laryngitis and infection with human papillomaviruses]. | cancer of the larynx is one of the most prevalent tumors of the head and neck, with its prognosis dependent on early diagnosis. a number of authors have now reported a connection between head and neck cancers and infection with human papilloma virus (hpv). a large number of these tumors has been found to be hpv 16/18 positive, with results ranging from 10% to 75% positive. it is currently known that viral infection alone cannot realize an oncogenic potential and there have to be exogenous and/or ... | 1993 | 8386152 |
| [human papilloma virus infections in adult women in panama]. | this study shows that 10% of panamanian women are infected with vph. this incidence of premalign and malign infection is one of the highest in the world. it is necessary that panamanian women be educated to participate in the program of the early detection of the disease to control the incidence of cancer in the uterine cervix. | 1993 | 8386390 |
| analysis of prevalence of human papillomavirus in laryngeal carcinomas. study of 40 cases using polymerase chain reaction and consensus primers. | in this study we determined the frequency of association of human papillomavirus (hpv) and laryngeal carcinomas and investigated the possibility that hpv may be associated with larger or more aggressive tumors. laryngeal squamous cell carcinomas from 40 patients who did not have preexisting papillomas by clinical history were retrieved from formalin-fixed, paraffin-embedded blocks and analyzed for hpv. twenty-two cases were tumors of the true vocal folds, and 18 were supraglottic. clinical follo ... | 1993 | 8386490 |
| human papillomavirus in primary epithelial tumors of the lacrimal sac. | the lacrimal sac epithelium can give rise to benign and malignant neoplasms. human papillomavirus (hpv) infection is known to be causal in the development of epithelial neoplasias elsewhere in the body. the authors have examined primary lacrimal sac tumors for the presence of hpv. | 1993 | 8386822 |
| [in vivo identification of yb-1 protein, interacting with the enhancer of human papillomavirus (hpv) type 18, using antibodies to a synthetic peptide]. | enhancer sequences of human papilloma virus (hpv) type 18 were used for screening of hela cells cdna library in lambda gt11 using the protein binding method. clones with yb i gene homology sequences were isolated. this gene is coding the protein which binds the regulatory region of y gene of main histocompatibility complex (hla 11). the yb i transcripts were revealed in all tested samples of cervical carcinomas. to analyze the protein the rabbit antibodies were produced to synthetic peptide, whi ... | 1993 | 8387154 |
| human papillomavirus infection in papillomas and nondiseased respiratory sites of patients with recurrent respiratory papillomatosis using the polymerase chain reaction. | we examined human papillomavirus (hpv) infection in biopsy specimens and cellular scrapes that were taken from respiratory papillomas and six nondiseased sites from the respiratory tract of seven patients. human papillomavirus was detected by polymerase chain reaction amplification, followed by dna hybridization with probes for specific hpv types. all papillomas (100.0%, n = 5) were positive only for hpv type 6 or 11. in the nondiseased site specimens, 61.3% (19/31) of the specimens were positiv ... | 1993 | 8387317 |
| genital types of papillomavirus in children of women with hiv-1 infection in kinshasa, zaire. | increasing evidence indicates that infection with genital types of human papillomavirus (hpv) can occur prior to the onset of sexual activity, possibly by perinatal transmission. evidence is also accumulating that women infected with the human immunodeficiency virus (hiv) more frequently express hpv. we conducted this study to measure hpv prevalence in hiv-seropositive and -seronegative women in kinshasa, zaire and in their children. we collected cervico-vaginal lavage specimens from 80 mothers ... | 1993 | 8387461 |
| prognostic significance of human papillomavirus genomes (type-16, -18) and aberrant expression of p53 protein in human esophageal cancer. | the presence and distribution of human papillomavirus (hpv) dna or of increased expression of the p53 protein were determined in 71 patients with esophageal squamous-cell carcinoma (scc) by in situ hybridization with biotinylated dna probes for hpv-16, -18, -31 and -33, and immunohistochemical techniques using antibody to p53 protein. of 71 patients from kochi prefecture, 24 (group i) were positive for hpv dna, including 10 for hpv type-16 and 14 for hpv type-18; in contrast, none were positive ... | 1993 | 8387463 |
| analysis of human papillomavirus dna in oral squamous cell carcinomas. | evidence from several laboratories suggests that hpv plays a role in the etiology of squamous cell carcinomas of the oral cavity. a multifactorial risk factor profile for the development of oral cancer may include hpv in addition to well-established risk factors such as tobacco and alcohol use. the prevalence of oral carcinomas reported to be associated with hpv has varied widely due to differences in the sensitivity of the assay used for hpv detection. the aims of this study were: (1) to ascert ... | 1993 | 8387592 |
| evolution of the antibody response to human papillomavirus type 11 (hpv-11) in patients with condyloma acuminatum according to treatment response. | to evaluate the variation over time of seroreactivity to human papillomavirus type 11 (hpv-11) according to disease outcome, we selected a sample of 42 condyloma acuminatum patients from a group of subjects enrolled in a placebo-controlled trial of three alpha-interferon preparations administered parenterally for the treatment of condyloma acuminatum. this sample included 14 subjects who were cured by the end of follow-up (cured group) and 28 subjects who were not (failed group). for each indivi ... | 1993 | 8388030 |
| repression of endogenous p53 transactivation function in hela cervical carcinoma cells by human papillomavirus type 16 e6, human mdm-2, and mutant p53. | somatic mutations in the p53 tumor suppressor gene represent the single most common genetic alteration observed in human cancers. interestingly, the great majority of malignant tumors of the cervix uteri contain wild-type p53 alleles together with the dna of specific types of human papillomaviruses (hpvs), while the small portion of hpv-negative cervical carcinomas often carry alterations in the p53 tumor suppressor gene. transcriptional activation of yet-undefined cellular regulatory genes has ... | 1993 | 8388491 |
| inhibition of growth, transformation, and expression of human papillomavirus type 16 e7 in human keratinocytes by alpha interferons. | we used a model system of normal human keratinocytes (hkc) and hkc immortalized with human papillomavirus type 16 dna (hkc/hpv16) to investigate the effects of alpha interferons (ifn-alpha) on the growth of hpv16-immortalized human epithelial cells, on hpv16-mediated immortalization of normal hkc, and on hpv16 gene expression. normal hkc and hkc/hpv16 were treated with several recombinant human ifn-alpha subtypes (ifn-alpha b, ifn-alpha d, and ifn-alpha b/d). these ifn-alpha subtypes inhibited p ... | 1993 | 8388505 |
| smoking and human papillomavirus infection. cervical epithelium vulnerable in smokers. | 1993 | 8388757 | |
| frequency of sexually transmitted diseases among university students. | to estimate the incidence rate of sexually transmitted diseases (stds) among university students and evaluate the associated sociodemographic factors. | 1993 | 8388772 |
| behavior of cervical intraepithelial neoplasia (cin) associated with various human papillomavirus (hpv) types. | 201 cervical punch biopsies which showed cin lesions and were obtained between 1967 to 1977 from falu hospital patients, with long-term follow-up data were examined histologically and by dna typing for human papillomavirus (hpv). we used in situ hybridization for hpv types 6, 11, 16, 18, 31 and 33 and related our findings to the behaviour of the lesion (103 regressed spontaneously and 98 progressed, some of them to invasive cervical carcinoma). there was evidence of hpv infection in 75.6% (152/2 ... | 1993 | 8389112 |
| is human papillomavirus-related disease an independent risk factor for human immunodeficiency virus infection? | we sought to determine the prevalence of human immunodeficiency virus (hiv) infection in a population of women with human papillomavirus (hpv)-related diseases attending a colposcopy clinic who had no other cdc-defined risk factors for hiv. study patients included all new patients attending our colposcopy clinic who were found to have histologic evidence of condyloma or cervical intraepithelial neoplasia. those patients not already known to be hiv-positive were offered testing for hiv. demograph ... | 1993 | 8389313 |
| possible non-sexual transmission of genital human papillomavirus infections in young women. | human papillomaviruses were detected by an in vitro enzymatic dna amplification method in cells obtained from vulvar swabs of 9 of 61 (14.8%) young women without prior experience of sexual intercourse and in 7 of 57 (12.3%) young women with prior experience. the prevalence of human papillomavirus dna in these two groups of women was not significantly different (x2 = 0.16, p > 0.5; 95% confidence interval -0.165 to 0.215). these results suggest that genital human papillomavirus is not sexually tr ... | 1993 | 8389707 |
| gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines. | using immunocytochemical and western blotting techniques we have demonstrated the presence of abnormally high levels of p53 protein in 8/24 (33%) of human squamous cell carcinomas (scc) and 9/18 (50%) of scc cell lines. there was a correlation between the immunocytochemical results obtained with eight scc samples and their corresponding cell lines. direct sequencing of pcr-amplified, reverse transcribed, p53 mrna confirmed the expression of point mutations in six of the positive cell lines and d ... | 1993 | 8390283 |
| hairy leukoplakia after bone marrow transplantation. | hairy leukoplakia in 10 patients after bone marrow transplantation was identified clinically and assessed histologically. in situ hybridization for epstein-barr virus and human papilloma virus confirmed epstein-barr virus in hairy leukoplakia in two cases, and human papillomavirus in three cases. all cases with clinical follow-up resolved without treatment. these findings suggest that severe immunosuppression after a bone marrow transplantation may result in the development of hairy leukoplakia, ... | 1993 | 8390632 |
| papillomavirus infection and its pathologic correlate in sexually active adolescents. | we investigated the prevalence of human papillomavirus (hpv) and its pathologic correlation in an adolescent clinic population (13-20 years, mean 16 years) over a 2-year period. 413 cervical specimens were obtained and analyzed cytologically and by a southern blot (sb) method for hpv dna. 277 specimens from 210 patients could be fully analyzed. 23 patients (10.9%) were positive for hpv dna by sb. cytologic findings in these 23 patients demonstrated changes compatible with low-grade squamous intr ... | 1993 | 8390646 |
| hpv, hiv infection, and risk of cervical intraepithelial neoplasia in former intravenous drug abusers. | the relation between human immunodeficiency virus (hiv), human papilloma virus (hpv) infection, sexual habits, reproductive history, and risk of cervical intraepithelial neoplasia (cin) has been analyzed in a cross-sectional study conducted since 1986 among female former intravenous drug abusers attending for the first time to the colposcopic unit of the ospedale luigi sacco of milan and women consecutively admitted to the community for past drug abusers, s. patrignano, rimini. a total of 434 su ... | 1993 | 8390961 |
| [expression of human papillomavirus (hpv) gene in hpv-positive laryngeal tumors and activity of the hpv long control region in cultured normal laryngeal epithelial cells]. | expression of the human papillomavirus (hpv) gene was examined in hpv-positive laryngeal tumors. moreover, the activity of the hpv long control region (lcr) was tested in cultured laryngeal epithelial cells. hpv-11 early genes were heterogeneously expressed in adult laryngeal papillomas. we found one laryngeal carcinoma case in whom the hpv-16 transforming genes, e6 and e7, were expressed. both hpv-11 and -16 lcrs were active in cultured laryngeal epithelial cells from vocal cords. these results ... | 1993 | 8391073 |
| [human papilloma virus infection in the case of larynx carcinoma]. | the case of 59 year old man treated for larynx carcinoma was presented. the potentially oncogenic human papillomavirus type 16/18 was detected in the tissue surrounding the tumor. | 1993 | 8391130 |
| construction of site-specific mutants of e5a protein of hpv-11 using the polymerase chain reaction and a single mutant primer. | the method of perrin and gilliland (1990) was modified to create site-specific mutants. the polymerase chain reaction and a single mutant primer are needed to carry out site-specific mutagenesis. using this method, removal of the excess primers and nucleotides from the initial amplification is not necessary. this method provides a simpler way to generate site-specific mutants. | 1993 | 8391542 |
| human papillomavirus dna in the urogenital tracts of men with genital dermatoses: evidence for multifocal infection. | in an attempt to assess the multifocal nature of anogenital hpv infection in men, skin biopsies, urethral swabs and urine specimens were obtained from 100 men with genital dermatoses. the specimens were examined for the presence of human papillomavirus (hpv) types 6, 11, 16, 18, 31 and 33 using the polymerase chain reaction and southern blotting techniques. hpv dna was detected in one or more specimens from 39 patients, that is 29 of 100 biopsy specimens, 21 (25%) of 85 urethral swab specimens a ... | 1993 | 8391854 |
| demonstration of human papillomavirus type 2 in a verrucous carcinoma of the foot. | this report describes one case of verrucous carcinoma of the foot containing human papillomavirus type 2 dna which was detected by the polymerase chain reaction dna amplification method. our findings suggest that human papillomavirus type 2, which was classically associated with palmoplantar warts, may also play a role in the pathogenesis of peripheral verrucous carcinoma. | 1993 | 8391880 |
| immunohistochemical analysis of p53 expression in anal squamous neoplasia. | to determine the pattern of expression of the p53 tumour suppressor gene product in anal squamous neoplasia, and to determine if this could be used as a marker of disease progression. the association between p53 expression and human papillomavirus (hpv) 16 dna status of the anal lesions was also investigated. | 1993 | 8392521 |
| high- and low-power co2 lasers. comparison of results for three clinical indications. | in this prospective study, three groups of patients were enrolled: group 1, patients with high grade squamous intraepithelial lesions (cin 2 and 3) and carcinoma in situ (n = 56); group 2, patients with benign vulvar and perineal human papillomavirus lesions (n = 83); and group 3, patients with disseminated foci of penile shaft condylomatous lesions (n = 65). each of the groups was randomly equally divided into two subgroups. one subgroup was treated with a laser beam with an output of 60 w and ... | 1993 | 8392581 |
| nuclear factor i and epithelial cell-specific transcription of human papillomavirus type 16. | the transcription of human papillomavirus type 16 (hpv-16) is mediated by the viral enhancer. epithelial cell-specific activation is achieved by the cooperative interaction of apparently ubiquitous transcriptional factors. one of them, nuclear factor i (nfi), binds seven sites within the hpv-16 enhancer. point mutations on enhancer fragments, which retain epithelial cell specificity, verify the functional contribution of nfi. in band shift experiments, the epithelial cell-derived nfi proteins ct ... | 1993 | 8392590 |
| biology and colposcopic features of human papillomavirus-associated cervical disease. | target biopsy and transformation zone ablation on excision is the mainstay of management for cervical lesions that can be adequately visualized. for the physician who does not progress beyond whimsical estimates of lesion prominence (which cannot differentiate minor- from major-grade lesions), the colposcope will never be more than a simple aid to the collection of directed biopsy specimens. unfortunately, in situations in which the clinician's only option is passive response to the histopatholo ... | 1993 | 8392673 |
| colposcopy of vaginal and vulvar human papillomavirus and adjacent sites. | human papillomaviral infections can affect the entire lower female genital tract as multifocal or multicentric disease as well as the surrounding anatomic and adjacent sites. the traditional colposcopic methods are necessary to assist in the diagnosis and help differentiate these infections from other disease mimics. | 1993 | 8392676 |
| pathogenesis of genital hpv infection. | clinical, subclinical, and latent human papillomavirus (hpv) infections are distinguished from hpv-associated neoplasia. besides hpv additional cofactors are necessary to transform hpv infected tissue to intraepithelial or invasive neoplasia. risk factors for the presence of hpv are high number of sexual partners, early cohabitarche, young age at first delivery, suppression and alteration of immune status, young age and hormonal influences. while the fact of a high number of sexual partners excl ... | 1993 | 8392965 |
| high rate of concurrent genital infections with human cytomegalovirus and human papillomaviruses in cervical cancer patients. | a case-control study evaluated a possible association between infection with human papillomavirus (hpv) or cytomegalovirus (cmv) and cervical cancer. seventy-eight patients with cervical cancer (cases) were compared with 55 age-compatible patients with uterine leiomyoma (controls). genital cmv and hpv infections were diagnosed by polymerase chain reaction amplification of viral dna in cervical tissues. smoking, first coitus or pregnancy before age 20, multiple sex partners, history of multiple p ... | 1993 | 8393059 |
| human papilloma virus: implications for medical directors. | 1993 | 8393222 | |
| mutations of p53 and human papillomavirus infection in cervical carcinoma. | oncogenic human papillomavirus (hpv) infection has been implicated in the pathogenesis of cervical carcinoma. the hpv oncoproteins e6 and e7 are though to play a crucial role in this process by their interactions with the p53 protein and the retinoblastoma susceptibility gene product, respectively. the e6 protein binds to and stimulates the degradation of the p53 protein. mutations involving evolutionary conserved regions of the p53 gene also can alter p53 function. point mutations of p53 freque ... | 1993 | 8393371 |
| interactions of human papillomavirus transforming proteins with the products of tumor suppressor genes. | human papillomaviruses (hpvs) contribute to the development of almost all cervical cancers, a common and often fatal human disease. the mechanisms by which the hpvs function in malignant progression appear to be related to the activity of the two viral oncoproteins, e6 and e7, which form complexes with several cell proteins normally involved in controlling cell growth. of particular interest has been the association of e6 with p53 and e7 with rb, both products of tumor suppressor genes. expressi ... | 1993 | 8393818 |
| viral gene detection in oral neoplasms using the polymerase chain reaction. | eighty-four squamous cell proliferative lesions of the oral cavity and six examples of normal oral squamous mucosa were investigated for the presence of human papillomavirus (hpv) by the polymerase chain reaction (pcr) using universal primers and type specific probes. human papillomavirus was identified in 1 of 6 histologically normal biopsy specimens, 2 of 4 hyperplasias, 2 of 5 inflammatory lesions, 9 of 36 cases of dysplasia or carcinoma in situ, and 7 of 39 carcinomas. all of the specimens f ... | 1993 | 8394047 |
| multiple human papillomavirus type 16 glucocorticoid response elements functional for transformation, transient expression, and dna-protein interactions. | we have previously shown that human papillomavirus type 16 (hpv-16) can efficiently transform primary baby rat kidney cells in the presence of the steroid hormones progesterone and the glucocorticoid dexamethasone. to study this effect of hormone, different combinations of the previously identified glucocorticoid response element (gre) at nucleotide 7640 of hpv-16 and the other two gres that we have recently identified, at nucleotides 7385 and 7474, were mutated. the previously described gre and ... | 1993 | 8394465 |
| [a new method, based on in situ dna hybridization, for the detection of papillomavirus in condyloma patients and their partners]. | the detection and typing analysis of human papillomavirus (hpv) were carried out by means of biohit in situ hpv dna hybridization screening and typing kits in condyloma tissues of patients with genital condyloma acuminatum, in cytological smears of their asymptomatic female consorts, and in female patients with vulval condyloma acuminatum. "low"-risk hpv 6 and hpv 11 were demonstrated most frequently in the condyloma tissues of the male patients. it is noteworthy that all but one female consorts ... | 1993 | 8394562 |
| flat wart of the urethra caused by human papillomavirus type 16. | a rare case of urethral flat wart caused by human papillomavirus (hpv) type 16 was reported. a 34-year-old male consulted our department with a complaint of urethral bleeding. a pair of symmetrical white flat warts combined with ulcer at the urethral meatus were found. microscopic examination of the specimen demonstrated koilocytosis of the epithelium. in immunohistochemical study it was positive for hpv and hpv type 16 was detected by polymerase chain reaction. | 1993 | 8394608 |
| sequence variation in the noncoding region of human papillomavirus type 16 detected by single-strand conformation polymorphism analysis. | human papillomavirus (hpv) type 16 variants were found by single-strand conformation polymorphism (sscp) analysis of the noncoding region of the viral genome. two sets of primers were used to analyze a 1018 bp region spanning nucleotides 7109-222. twelve sscp patterns were demonstrated among hpv 16 dnas purified from 48 anal specimens from 24 homosexual men. seven patterns were detected among 10 hpv 16 isolates from cervical carcinomas. in two pairs of sex partners, identical variants were recog ... | 1993 | 8394860 |
| langerhans cells and human papillomaviruses in oesophageal and laryngeal carcinomas. | human papillomavirus (hpv) infection is implicated in squamous cell carcinogenesis. oesophageal carcinoma has a high incidence in certain geographical regions and, using different methods of detection, hpvs have been found in these tumours. hpv 6 and 11 are frequently detected in laryngeal papillomas, benign lesions which rarely become malignant. hpvs have been detected in squamous carcinoma of the larynx but more frequently, especially hpv 16, in verrucous carcinomas a distinct variant of squam ... | 1993 | 8395235 |
| [cloning and characterization of the genome of human papilloma virus type 16 in china]. | the cloning and characterization of a whole genome of human papillomavirus type 16(7.9kb) and a 5.4kb subgenomic fragment were studied. they were cloned after insertion in plasmid pat153, using its unique bamh1 site. the full-length genome and subgenomic fragment were designated hpv16z and hpv16f respectively. after analysis by 16 endonucleases, no new restriction site was found in hpv16z in comparison with the standard strain. a new bamh1 site was observed at the 750 bp position in hpv16f. usin ... | 1993 | 8395318 |
| biological and biochemical activity of e7 genes of the cutaneous human papillomavirus type 5 and 8. | in contrast to the observed activity of the e7 genes of the genital high-risk human papillomavirus (hpv)16 and hpv18, e7s of the cutaneous high-risk hpv5 and hpv8 show no in vitro transforming activity in established rodent cells. we recently reported that the hpv8 e7 driven by the sv40 enhancer/promoter oncogenically transforms primary rat embryo fibroblast (ref) cells collaboratively with the ejras oncogene (jpn. j. cancer res., 82, 1340-1343, 1991). to study the functional differences between ... | 1993 | 8395681 |
| analysis of the growth properties and physical state of the human papillomavirus type 16 genome in cell lines derived from primary cervical tumors. | we have established three cell lines from keratinizing and nonkeratinizing cervical carcinomas with distinct growth properties in vitro and in vivo. each cell line contained human papillomavirus type 16 dna sequences, but the lines differed in the physical state of the viral genome present in the cells. a high copy number of episomal human papillomavirus type 16 dna sequences was detected in the tc-140 line derived from a keratinizing cervical cancer. this cell line had an aneuploid karyotype, d ... | 1993 | 8395773 |
| human papillomavirus-induced verrucous carcinoma of the mouth. case report of an aggressive tumor. | 1993 | 8396162 | |
| hpv dna in oropharyngeal squamous cell cancers: comparison of results from four dna detection methods. | oropharyngeal squamous cell cancers (sccs) were examined for human papillomavirus (hpv) related dna sequences. the techniques employed were southern blotting under stringent and non stringent conditions, dot blotting, primer directed gene amplification using the polymerase chain reaction (pcr), and in-situ hybridization. hpv 16 dna was found in 4 of 30 tumor samples using pcr. hpv 16 dna was found in 2 further tumors using in-situ hybridization. no hpv dna could be found by southern blot or dot ... | 1993 | 8396231 |
| in vitro hpv-11 infection of human foreskin. | study of the infectious process of human papillomavirus type 11 (hpv-11) has been facilitated by the discovery that hpv-11-infected neonatal human foreskin epithelium can proliferate as xenografts into condyloma-like growths within athymic nude mice. here we describe detection of hpv-11 infection of neonatal human foreskin-derived keratinocytes, infected and cultured entirely in vitro, by use of the polymerase chain reaction and primers straddling the splice donor/acceptor site of the most preva ... | 1993 | 8396606 |
| benign leydig cell tumor of the testis associated with human papillomavirus type 33 presenting with the sign of leser-trélat. | we present a case of a benign testicular leydig cell tumor and eruptive seborrheic keratosis associated with human papillomavirus type 33 infection. to our knowledge this is the first occurrence of a leydig cell tumor in a patient with tuberous sclerosis and the second documented case of eruptive seborrheic keratoses (sign of leser-trélat) associated with a benign neoplasm. | 1993 | 8396689 |
| human papillomavirus type 18 dna in so-called hep-2, kb and fl cells--further evidence that these cells are hela cell derivatives. | the contamination of hela cells into many culture cells has been suspected. we detected hpv type 18 dna in two hela cell sublines, hep-2 laryngeal cancer and kb oral cancer cell lines as well as fl cell line derived from normal amniotic membrane which have been extensively used so far in experimental virology. on the other hand, we detected hpv type 18 dna neither in other epithelial cell lines nor in fibroblastic human embryonic cells. the digestion analysis with several restriction enzymes of ... | 1993 | 8397027 |
| [a case of verrucous carcinoma of the penis with detection of human papillomavirus using the in situ hybridization method]. | a case of penile verrucous carcinoma is reported. the patient had a previous history of condyloma acuminatum of the penis. no signs of squamous cell carcinomas were observed in the histopathological findings. we also detected the histologic evidence of human papilloma virus (hpv) infection in the result of the study by in situ hybridization. the local positive reaction of hpv infection for type 6/11 was seen, and was related to the koliocytosis. however other types of hpv (16/18, 31/33, 51) were ... | 1993 | 8397482 |
| sexually transmitted diseases in adult, non-pregnant women. | most of the publications reviewed focus on human papillomavirus (hpv), and a small proportion on herpes simplex virus (hsv), chlamydia trachomatis, as well as the syndromes of pelvic inflammatory disease and bacterial vaginosis. the present hypothesis associates cervical intraepithelial neoplasia (cin)-1 with high oncogenic risk hpv types in less than 30% of cases; whereby cin-2 and cin-3 are associated with a 90% risk. however, on the basis of hpv types, four categories ['low risk' (hpv 6/11, 4 ... | 1993 | 8400052 |
| screening for human papillomavirus infections in esophageal squamous cell carcinomas by in situ hybridization. | infections with specific types of human papillomavirus (hpv) have been closely linked with human squamous cell carcinomas, those of the anogenital tract in particular. increasing number of reports also suggest that hpv infection could be a risk factor for esophageal cancer. however, most of the previous studies on hpv involvement in esophageal carcinomas have included only small numbers of biopsy specimens, thus necessitating additional studies based on extensive series of esophageal samples. | 1993 | 8402471 |
| [the treatment of cervical human papillomavirus (hpv) infection with trichloroacetic acid]. | ever since the alterations caused by the hpv on the cervix were discovered, countless treatments have been employed but the ideal method still remains unknown. the objective of the experiment was to assess the efficiency of handling the cervical infection caused by the hpv, by means of trichloroacetic acid, 85% rate. during the period comprised between april 1989 and march 1990, 60 patients were subject to close analysis. the general diagnosis drawn cytology, colposcopy, and histopathology was c ... | 1993 | 8406118 |
| study of the partners of women with human papillomavirus infection. | genital human papillomavirus (hpv) infection is one of the most common sexually transmitted diseases, and it has been identified as a significant risk factor for the development of dysplasia and cancer of the uterine cervix. the possible influence of male hpv lesions on female cervix oncogenesis has not been elucidated so far. in the present study we evaluate the male partners of women with clinical or subclinical hpv infection with particular interest in the clinical features of this infection ... | 1993 | 8407094 |
| human papillomavirus and cutaneous warts in meat handlers. | the association of papillomavirus and hand warts in meat handlers was examined. human papillomavirus (hpv) dna was found in 23 (88%) of 26 cutaneous warts, with hpv 7 (27%) and a yet unidentified hpv (hpv x) (42%) being the predominant types. hpv 2 was found in two (7.5%) patients, and hpv 4 was found in three (11.5%) patients. no bovine papillomavirus sequences were detected. in most patients, the warts developed in less than 2 years after they started working with meat. a possible hpv transmis ... | 1993 | 8408588 |
| an evaluation of oral ulcers in patients with aids and aids-related complex. | patients with hiv infection can have recurrent and persistent oral ulcers, not attributable to known infectious agents. | 1993 | 8408791 |
| evolution of human papillomavirus type 18: an ancient phylogenetic root in africa and intratype diversity reflect coevolution with human ethnic groups. | papillomaviruses are an ideal model system for the study of dna virus evolution. on several levels, phylogenetic trees of papillomaviruses reflect the relationship of their hosts. papillomaviruses isolated from remotely related vertebrates form major branches. one branch of human papillomaviruses (hpvs) includes an ape and two monkey papillomaviruses, possibly because the diversification of the viruses predated the separation of the infected-primate taxa. this hypothesis predicts that the root o ... | 1993 | 8411344 |
| mhc class i expression in hpv 16 positive cervical carcinomas is post-transcriptionally controlled and independent from c-myc overexpression. | squamous cell carcinomas of the uterine cervix (n = 23) were selected for the presence of human papillomavirus type 16 (hpv 16) using the polymerase chain reaction (pcr). localization of transcripts coding for the e7 protein was demonstrated in neoplastic cells with rna in situ hybridization. consecutive tissue sections were investigated for expression of the major histocompatibility complex class i (mhc-i) and c-myc using immunohistochemical double staining procedures, since a role has been sug ... | 1993 | 8414499 |
| low prevalence of human papillomavirus types 16 and 18 in cervical adenocarcinoma in situ, invasive adenocarcinoma, and glandular dysplasia by polymerase chain reaction. | using the polymerase chain reaction on paraffin blocks for human papillomavirus (hpv) types 16 and 18, a positive result was seen in three of 20 cases of invasive adenocarcinoma, 15 of 36 cases of adenocarcinoma in-situ, and one of five cases of glandular dysplasia of the uterine cervix. types 16 and 18 were found with equal frequency. in adenocarcinoma in situ there was no age difference between hpv-positive and or hpv-negative cases. concomitant squamous dysplasia was slightly more frequent in ... | 1993 | 8415587 |
| transmission of human genital papillomavirus disease: comparison of data from adults and children. | a substantial body of evidence has demonstrated that the primary means of transmission of genital warts in sexually active adults is through sexual contact. however, the epidemiology and social significance of anal-genital warts in prepubertal children is controversial. debate continues regarding the frequency with which these lesions have resulted from sexual abuse or transmission by other means. an accurate understanding of the dominant means of transmission of anal-genital warts in children i ... | 1993 | 8416503 |
| an epidemiologic perspective on biomarkers. | the authors discuss biological markers from an epidemiologic perspective, emphasizing the importance of integrating biomarkers into large-scale observational and intervention studies. whereas any biologic phenomenon can be considered a biomarker, an intermediate end-point is defined as being on the causal pathway between exposure and disease. an intermediate end-point is a valid surrogate for a disease in relation to a given exposure if, and only if, that exposure causes a similar change in the ... | 1993 | 8429292 |
| bowenoid changes in kaposi's sarcoma. | previous reports have documented the coexistence of multiple infectious organisms or kaposi's sarcoma within the same biopsy specimens of mucocutaneous lesions in human immunodeficiency virus- (hiv) infected patients. | 1993 | 8454785 |
| electron microscopy visualization of oligonucleotide binding to duplex dna via triplex formation. | using biotinylated oligonucleotides and streptavidin as a marker, we have visualized, with the help of electron microscopy, the triplex formation. we used the natural homopurine-homopyrimidine sequence from human papillomavirus 16 cloned within a plasmid. under conditions favouring the formation of pyrimidine-purine-pyrimidine triplex the corresponding pyrimidine oligonucleotide formed a complex with the insert and this complex was detected by electron microscopy. similarly, under conditions fav ... | 1993 | 8464052 |
| verrucous carcinoma of the genital tract: is it a distinct entity? | between 1974 and 1985, 16 patients (7 men, 9 women) with a diagnosis of genital verrucous carcinoma were identified from the cancer registry of the tom baker cancer centre in calgary. all the men had lesions on the penis. in the women, five lesions were on the vulva, four were on the cervix and two were on the vagina (two women each had two involved sites). the histologic slides from the surgically excised specimens were reviewed, and, by applying strict criteria, all cases could be reclassified ... | 1993 | 8472225 |
| is hiv infection associated with an increase in the prevalence of cervical neoplasia? | to test the hypotheses: (1) that hiv infection predisposes to cervical intraepithelial neoplasia (cin); (2) that this cin is a result of hiv related immunosuppression; and (3) that this cin is a result of immunosuppression causing increased expression of the potentially oncogenic viruses, human papilloma virus (hpv), epstein barr virus (ebv) and herpes simplex virus (hsv). | 1993 | 8476807 |
| determinants of the geographic variation of invasive cervical cancer in costa rica. | the incidence of cervical cancer in costa rica is about twice as high in the coastal regions as in the interior. to study these regional variations, we used data from a 1986-1987 case-control study of 192 costa rican women with invasive cervical cancer and 372 controls. risk factors identified included the following: the study participant's (1) number of sexual partners, (2) age at first sexual intercourse, (3) number of live births, (4) presence of type 16/18 human papillomavirus (hpv) dna, (5) ... | 1993 | 8490673 |
| biological activities of p53 mutants in burkitt's lymphoma cells. | wild-type human p53 and a series of p53 point mutants isolated from burkitt's lymphoma (bl) cell lines were tested for their ability to inhibit dna synthesis in a p53-negative bl cell line and to bind and be degraded by the human papillomavirus type 16 e6 protein. all the mutants lost the wild-type ability to inhibit dna synthesis, demonstrating that they are all functionally altered. binding to e6 and consequent degradation of the p53 mutants frequently correlated with changed suppressor proper ... | 1993 | 8492087 |
| kaposiform hemangioendothelioma of infancy and childhood. an aggressive neoplasm associated with kasabach-merritt syndrome and lymphangiomatosis. | we report the clinical and pathological features of nine distinctive, but relatively unknown, vascular tumors of infancy and childhood presenting as soft tissue masses often associated with locally aggressive disease, lymphangiomatosis and kasabach-merritt syndrome. the patients, four males and five females, were all in their first decade of life except for two (median, 2 years; range, 5 months to 19 years). these tumors involved deep soft tissues of the upper extremity (four cases), retroperito ... | 1993 | 8494101 |
| the aetiology and risk factors for warts among poultry processing workers. | we conducted an investigation at a poultry processing plant in new zealand to estimate the prevalence of warts among workers and the risk of developing warts associated with specific work areas or individual work practices. we obtained information on demographic characteristics and self-reported medical and occupational histories from 88 (83%) of 106 permanent employees at the plant; almost half (39 people or 44%) had developed wart-like lesions on their arms or hands after they began working at ... | 1993 | 8505187 |
| regulation of human papillomavirus transcription by the differentiation-dependent epithelial factor epoc-1/skn-1a. | human papillomavirus (hpv) early gene expression is closely linked to the differentiation status of infected epithelial cells. typically, hpv type 16 (hpv16) or hpv18 e6 and e7 transcripts are only barely detectable within the undifferentiated basal cell layer, but their levels increase concomitantly with higher degrees of epithelial cell differentiation in suprabasal cells. a similar differentiation-dependent distribution of expression has been reported for the recently cloned epithelial cell s ... | 1996 | 8523512 |
| prevalence of human papillomavirus dna in female cervical lesions from rio de janeiro, brazil. | a hundred-sixty paraffin-embedded specimens from female cervical lesions were examined for human papillomavirus (hpv) types 6, 11, 16 and 18 infections by non-isotopic in situ hybridization. the data were compared with histologic diagnosis. eighty-eight (55%) biopsies contained hpv dna sequences. in low grade cervical intraepithelial neoplasias (cin i), hpv infection was detected in 78.7% of the cases, the benign hpv 6 was the most prevalent type. hpv dna was detected in 58% of cin ii and cin ii ... | 1994 | 8524058 |
| degradation of the proto-oncogene product c-fos by the ubiquitin proteolytic system in vivo and in vitro: identification and characterization of the conjugating enzymes. | the transcription factor c-fos is a short-lived cellular protein. the levels of the protein fluctuate significantly and abruptly during changing pathophysiological conditions. thus, it is clear that degradation of the protein plays an important role in its tightly regulated activity. we examined the involvement of the ubiquitin pathway in c-fos breakdown. using a mutant cell line, ts20, that harbors a thermolabile ubiquitin-activating enzyme, e1, we demonstrate that impaired function of the ubiq ... | 1995 | 8524278 |
| human papillomavirus type 11 e1--e4 and l1 proteins colocalize in the mouse xenograft system at multiple time points. | the most abundant viral mrna species in hpv 11-infected tissue consists of two exons, joining a segment of open reading frame (orf) e1 to orf e4, potentially encoding the e1--e4 protein. the l1 orf encodes the major capsid protein of hpv. our previous studies demonstrated colocalization of the hpv 11 e1--e4 and l1 proteins within the same cells of hpv 11-infected human foreskin implants grown in athymic mice (the mouse xenograft system) and removed 12 weeks after implantation. prior studies have ... | 1995 | 8525625 |