Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| epidemic of meningitis and febrile illness in neonates caused by echo type 11 virus in philadelphia. | between april and november, 1980, an outbreak of meningitis and of febrile illness of neonates caused by echo 11 virus occurred in philadelphia and surrounding communities. thirty-eight virologically confirmed and ten virologically presumptive cases of meningitis were hospitalized in two philadelphia hospitals for children. most patients had fever and irritability. vomiting, upper respiratory symptoms and poor feeding were present in one-third to one-half of the cases. seventy-five percent of ca ... | 1983 | 6634464 |
| myopericarditis associated with echo virus type 3 infection--a case report. | a case with myopericarditis caused by type 3 echo virus was reported. the diagnosis was based on a significantly increased hemagglutination-inhibiting antibody titer (from 4:6 to 4:516) against type 3 echo virus in the acute and the convalescent phase. a 29-year-old male was hospitalized for chest pain and fever. the patient had congestive heart failure, pericardial effusion and temporarily appearing abnormal q waves on his electrocardiogram in the acute phase all of which gradually improved wit ... | 1983 | 6645036 |
| influence of host cells on the infectivity and neutralizability echovirus type 4 (pesascek). | the heterogeneity of echovirus type 4 (strain pesascek) is documented. this strain had a higher eop on rd cells than on gmk-ah1 or primary green monkey kidney cells. it was more effectively neutralized in tests on rd cells than on gmk-ah1 cells. the latter phenomenon was analyzed on materials of pesascek virus after banding in density gradients. a minor fraction was found that resisted neutralization as tested on either rd or gmk-ah1 cells. another fraction containing the main peak of infectivit ... | 1984 | 6735662 |
| [etiological study of uveitis in young children]. | the etiology of acute infectious diseases accompanied by uveitis in young children has been studied. in these investigations a high degree of contamination with virus echo 19 in patients with acute diseases accompanied by uveitis has been revealed and the ophthal motropic properties of the virus have been experimentally established, which indicates that certain variants of virus echo 19 play, probably, some role in the etiology of uveitis in young children. | 1984 | 6741369 |
| f-met-leu-phe and echo 9 virus interaction with human granulocytes. changes of cell membrane structure. | biophysical and biochemical methods were applied for investigation of cell membrane properties of human polymorphonuclear leukocytes (pmns) exposed to the chemotactic peptide n-formylmethionyl-leucylphenylalanine (f-met-leu-phe) and echovirus type 9, strain a, barty. steady-state fluorescence depolarization with diphenylhexatriene demonstrated no gross changes of the total membrane fluidity under the different experimental conditions. however, by means of the monomer-excimer technique with pyren ... | 1984 | 6742107 |
| [characteristics of echo-19 virus strain rad/40 causing an experimental lesion of the vascular coat of the eye (uveitis) in cynomolgus monkeys]. | four strains of echo-19 virus were isolated from a child with respiratory disease complicated with uveitis. a freshly isolated rad/40 strain of echo-19 virus was found to produce a severe disease of the vascular coat of the eye (uveitis) in javan cercopithecus monkeys inoculated directly into the anterior chamber of the eye. experimental uveitis is characterized by marked changes in the shape of the pupil, the lack of the pupil reaction to light, development of synechias, changes in the color of ... | 1982 | 6760552 |
| most echoviruses reach higher titers in rd than in gmk-ah 1 cells, regardless of their passage history. | stocks prepared in gmk-ah 1 cells of all 31 echovirus prototype strains were titrated simultaneously from identical dilution series in tube cultures of rd and gmk-ah 1 cells. 14 types reached titers 10 to 60 times higher in rd than in gmk-ah 1 cells. 10 other types titered 4 to 6 times higher in rd than in gmk-ah 1 cells. three prototypes only (nos. 1, 8 and 9) titered considerably lower in rd than in gmk-ah 1cells. echovirus types 22 and 23 did not replicate in rd cells. stocks of the various e ... | 1980 | 6766711 |
| [hyperbaric pressure effects ("per se" hydrostatic pressure, nitrogen and helium partial pressure) on the multiplication of a picornavirus (echo 11) in cell cultures (author's transl)]. | 1980 | 6768050 | |
| analysis of the directed and nondirected movement of human granulocytes: influence of temperature and echo 9 virus on n-formylmethionylleucylphenylalanine-induced chemokinesis and chemotaxis. | the directed movement of human polymorphonuclear leukocytes (pmn) in a plane (zigmond chamber assay) is described by a statistical model. we demonstrate that (a) the movement of a single cell is a superposition of a directed and a random movement, and (b) the degree of orientation, p1, of moving cells in a chemotactic gradient can be determined either by the time average of a single cell or by the average of movement of multiple cells at a fixed time (ergoden hypothesis). however, an homogeneous ... | 1983 | 6853601 |
| inability of counterimmunoelectrophoresis to detect echovirus in cerebrospinal fluid. | methods for rapid detection of viral antigens in cerebrospinal fluid (csf) are needed to aid in the differentiation of viral from bacterial meningitis. the formation of precipitin bands in patients with suspect viral meningitis utilizing viral antisera in a counterimmunoelectrophoresis (cie) system has been described. to investigate further the possible value of cie in the diagnosis of viral meningitis, the specificity of the csf precipitin bands was studied. precipitin bands were formed between ... | 1983 | 6881103 |
| [an epidemic of echovirus 33 infection in brittany]. | 1983 | 6881860 | |
| epidemiological studies on echovirus type 18 infection in toyama prefecture. | echovirus type 18 (echo 18) was isolated from six aseptic meningitis children in fukumitsu-machi, toyama prefecture, from july to august, 1980. this was the first virologically-confirmed epidemic of aseptic meningitis due to echo 18 in japan. epidemiological studies on the prevalence of this virus among the inhabitants in toyama prefecture were also performed. the results are summarized as follows. (1) significant increases in neutralizing antibody titers against echo 18 were observed in all the ... | 1983 | 6888292 |
| epidemiology of an outbreak in a maternity unit of infections with an antigenic variant of echovirus 11. | after an 8-day-old child had died with clinical signs of septicemia, 6 other newborns fell ill. virus was isolated from various sites from all the 6 children (28 isolations). the agent was identified by cross neutralization tests as an antigenic variant of echovirus 11. the agent could not be isolated from mothers or nursery staff (49 people). we therefore tried to trace the path of infection by isolating specific igm and igg antibodies. a laboratory infection by the agent isolated enabled the t ... | 1982 | 7069410 |
| echovirus 11 dense particles: isolation and preliminary characterization. | dense particles (density 1.44 g/ml) were isolated during purification in cscl of echovirus 11 produced in hela cells. the dense particles had similar antigenic properties and similar rna and protein composition to standard (density 1.33 g/ml) echovirus 11 particles. they differed from standard particles in their higher buoyant density, lower infectivity and slightly smaller diameter. in contrast to other picornavirus dense particles, echovirus 11 dense particles were present as a major component ... | 1982 | 7097249 |
| biochemistry and pathogenicity of echovirus 9. i. characterization of the virus particles of strains barty and hill. | 1982 | 7147713 | |
| selective inhibition of human neutrophilic chemotaxis by echo virus, type 9. virus-induced changes in membrane fluidity. | by means of the excimer-forming lipid technique changes of membrane fluidity of human pmns exposed to a chemoattractant (fmlp) and/or echo virus, type 9, strain a. barty has been investigated. it was shown that preincubation of pmns with echo 9 virus results in a viral dose-dependent decrease of membrane fluidity of granulocytes exposed to fmlp. the virus-induced rigidity of cell membrane causes obviously a disturbance in the aggregation of membrane particles to form receptors, and thus can lead ... | 1982 | 7182838 |
| perinatal echovirus infection: risk of transmission during a community outbreak. | during a community outbreak of enterovirus infection, seven of 194 pregnant women (3.6 per cent) were found to be excreting a prime strain of echovirus 11 at term. each of the seven women possessed serum neutralizing echovirus 11 antibody in titers ranging from 1:20 to 1:320, and the cord serum of their seven infants had antibody in titers of 1:10 to 1:640. none of these seven infants became ill, but four were shedding virus from the respiratory or gastrointestinal tract by three days of age. in ... | 1981 | 7254269 |
| selective inhibition of human neutrophil chemotaxis by echo-virus, type 9. | preincubation (37 degrees c, 60 min) of human neutrophilic granulocytes with various concentrations of infectious echo virus, type 9, strain a. barty resulted in virus-dose dependent inhibition of neutrophil chemotactic reactivity (boyden-chamber assay) to chemoattractants (f-met-leu-phen: zymosan-activated human serum). other cellular functions-phagocytosis, increase of oxidative cell metabolism, intracellular killing of live staphylococci--remained intact. this selective inhibition of human ne ... | 1981 | 7265813 |
| echovirus type 11 infection in melbourne--1953 to 1980. | echovirus type 11 (echo 11) has been isolated at the virus laboratory of fairfield hospital, melbourne, australia, in 20 of the 28 years since the laboratory was established. during this time two major epidemics have occurred; the first, in 1971-2 involved 90 patients with aseptic meningitis or respiratory illness. the second began in june 1979 and lasted for 11 months, during which echo 11 was isolated from 174 patients admitted to fairfield hospital, other victorian and tasmanian hospitals and ... | 1981 | 7288182 |
| the hemolytic uremic syndrome associated with echo 22 infection. | serologic evidence for echo virus 22 was found in 8 of 10 patients with hemolytic uremic syndrome. the virus was isolated from the stools of two patients. all these patients also had gastroenteritis prior to the development of the syndrome. the results of this study indicate that echo 22 virus is an agent with a strong association with hemolytic uremic syndrome in pediatric patients. | 1980 | 7351103 |
| fatal echovirus 11 disease in premature neonates. | four cases of fatal echovirus 11 disease occurred in premature infants during a community outbreak of enteroviral disease in massachusetts in 1979. each infant developed nonspecific symptoms and jaundice at 4 to 6 days of age, and subsequent progressive hepatic failure and generalized bleeding. only one infant survived longer than six days. virus was recovered from multiple sites premortem, and from virtually all tissue cultured at autopsy. myocarditis was not present clinically or pathologicall ... | 1980 | 7432883 |
| [effect of tannin, saponin and guanidine on the replication of echovirus 9 and its mutants]. | 1980 | 7464352 | |
| the role of cd8+ t lymphocytes in coxsackievirus b3-induced myocarditis. | coxsackievirus infections have previously been shown to cause acute or chronic myocarditis in humans, and several mouse models have been established to study the pathology of this disease. myocardial injury may result from direct viral effects and/or may be immune mediated. to determine the relative roles of these processes in pathogenesis, we have compared coxsackievirus b3 (cvb3) infections of normal and immuno-compromised transgenic knockout (ko) mice. cvb3 was able to infect all strains used ... | 1995 | 7474082 |
| characterization of a 100-kilodalton binding protein for the six serotypes of coxsackie b viruses. | viral infection of host cells primarily depends on binding of the virus to a specific cell surface protein. in order to characterize the binding protein for group b coxsackieviruses (cvb), detergent-solubilized membrane proteins of different cell lines were tested in virus overlay protein-binding assays. a prominent virus-binding protein with a molecular mass of 100 kda was detected in various cvb-permissive human and monkey cell lines but was not detected in nonpermissive cell lines. the specif ... | 1995 | 7474086 |
| colony-stimulating factors and coxackievirus b3 myocarditis in mice: macrophage colony-stimulating factor suppresses acute myocarditis with increasing interferon-alpha. | the effects of macrophage colony-stimulating factor (m-csf) and granulocyte colony-stimulating factor (g-csf) on murine coxsackievirus b3 myocarditis were investigated. a total of 4 x 10(6) u/kg/day m-csf and 20 micrograms/kg/day g-csf were injected subcutaneously every day on day 0 to day 14 starting simultaneously with virus inoculation. serum interferon-alpha was measured periodically. the survival rate of the m-csf group was higher than that of the untreated control group (p < 0.05). on days ... | 1995 | 7484779 |
| analysis of picornavirus 2a(pro) proteins: separation of proteinase from translation and replication functions. | the poliovirus (pv) genome was manipulated by replacing its 2a-encoding sequence with the corresponding sequence of coxsackie b4 virus (cbv4) or human rhinovirus type 2 (hrv2). in vitro translation of the resulting chimeric pv genomes revealed a normal cis-cleavage activity for both heterologous 2a(pro) proteinases in the chimeric pv polyproteins. however, only the genome containing the 2a-encoding sequence of cbv4 (pv/cbv4-2a) yielded viable virus in transfected cells, producing a mixture of la ... | 1995 | 7494250 |
| genetic analysis of a hydrophobic domain of coxsackie b3 virus protein 2b: a moderate degree of hydrophobicity is required for a cis-acting function in viral rna synthesis. | coxsackie b virus protein 2b contains near its c terminus a hydrophobic domain with an amino acid composition that is characteristic for transmembrane regions. a molecular genetic approach was followed to define the role of this domain in virus reproduction and to study the structural and hydrophobic requirements of the domain. nine substitution mutations were introduced in an infectious cdna clone of coxsackie b3 virus. the effects of the mutations were studied in vivo by transfection of buffal ... | 1995 | 7494289 |
| identification of serotype-specific and nonserotype-specific b-cell epitopes of coxsackie b virus using synthetic peptides. | coxsackie b viruses are thought to be involved in the induction of myocarditis. however, the diagnosis of acute infections by serology even today is practically impossible. the major problem is that no antigenic determinants of coxsackie b viruses have been identified or characterized which could be used as antigens in a rapid routine antibody screening test. therefore, we synthesized overlapping peptides according to the sequence of the capsid protein vp1 of coxsackie b3 (cb3) virus in order to ... | 1994 | 7513917 |
| bleomycin differentially inhibits picornavirus, herpesvirus and poxvirus replication in a human carcinoma cell line. | ms-757, a cervix carcinoma cell line, was exposed to bleomycin at concentrations up to 200 microm for periods of 1 to 24 hours. bleomycin treatment caused the level of dna synthesis in uninfected cells to drop to 13% of the level achieved in the controls. protein synthesis fell to 50%, but rna synthesis was not affected. exposure of uninfected cells to 200 microm bleomycin for 24 h did not induce significant cell death measured as permeability to trypan blue). a tetrazolium dye-reduction assay, ... | 1993 | 7514894 |
| decay-accelerating factor (cd55), a glycosylphosphatidylinositol-anchored complement regulatory protein, is a receptor for several echoviruses. | echoviruses are human pathogens belonging to the picornavirus family. decay-accelerating factor (daf) is a glycosylphosphatidylinositol (gpi)-anchored surface protein that protects cells from lysis by autologous complement. anti-daf monoclonal antibodies prevented echovirus 7 attachment to susceptible cells and protected cells from infection. hela cells specifically lost the capacity to bind echovirus 7 when treated with phosphatidylinositol-specific phospholipase c, an enzyme that releases gpi- ... | 1994 | 7517044 |
| [the clinical diagnosis and treatment of meningitis caused by coxsackie b viruses]. | clinical features of meningitis caused by coxsackie virus b were analyzed in 369 adult patients. the authors draw attention to polymorphism of manifestation and diagnostic signs of the diseases. reaferon used in complex treatment was established to be the most effective. the drug considerably shortened period of fever and drove away main clinical symptoms. | 1993 | 7518170 |
| neonatal coxsackievirus group b infections: experience of a single department of neonatology. | coxsackie infections in 14 infants born in a single neonatal unit were studied. the clinical presentation was mild nonspecific disease in eight infants and an overwhelming multiorgan disease in six. three infants with systemic disease died. vertical transmission of the virus from a colonized mother was documented in five mothers who infected seven infants. the remaining seven infants were infected horizontally, presumably from infected personnel. coxsackie b1 was isolated in four of the cases an ... | 1994 | 7518424 |
| antibodies to glutamic acid decarboxylase and p2-c peptides in sera from coxsackie virus b4-infected mice and iddm patients. | the possible role of amino acid sequence and epitope homologies between a protein p2-c of coxsackie virus b4 and human gad in the development of host-specific immune response in insulin-dependent diabetes mellitus (iddm) (molecular mimicry) was investigated. peptide antibodies to the p2-c protein, gad65, and gad67 were raised to analyze their immunoreactivity by enzyme-linked immunosorbent assay and immunoblotting with gad purified from the brain and pancreas of mice that develop hyperglycemia a ... | 1994 | 7523207 |
| decay-accelerating factor cd55 is identified as the receptor for echovirus 7 using celics, a rapid immuno-focal cloning method. | using an anti-receptor mab that blocks the attachment of echovirus 7 and related viruses (echoviruses 13, 21, 29 and 33), we have isolated a complementary dna clone that encodes the human decay-accelerating factor (cd55). mouse cells transfected with the cd55 clone bind echovirus 7, and this binding is blocked by the anti-receptor mab. the method used (celics) allows rapid and direct cloning of genes encoding cell surface receptors. it is based on episomal replication and high efficiency express ... | 1994 | 7525274 |
| coxsackievirus b3 adapted to growth in rd cells binds to decay-accelerating factor (cd55). | a coxsackievirus b3 (cb3) isolate adapted to growth in rd cells shows an alteration in cell tropism as a result of its capacity to bind a 70-kda cell surface molecule expressed on these cells. we now show that this molecule is the complement regulatory protein, decay-accelerating factor (daf) (cd55). anti-daf antibodies prevented cb3 attachment to the cell surface. radiolabeled cb3 adapted to growth in rd cells bound to cho cells transfected with human daf, whereas cb3 (strain nancy), the parent ... | 1995 | 7531780 |
| characterization of the n-terminal part of the neutralizing antigenic site i of coxsackievirus b4 by mutation analysis of antigen chimeras. | coxsackievirus b3 (cvb3) as a potential rna virus vector for the presentation of foreign antigenic epitopes was further characterized. insertion mutagenesis of infectious cvb3 cdna yielded viable antigen chimeras containing variant bc loops of vp1 of coxsackievirus b4 (cvb4). analysis of three antigen chimeras allowed the mapping of the n-terminal part of the neutralizing antigenic site 1 (n-ag1) of cvb4 which is located in the bc loop of the structural protein vp1. a significant neutralization ... | 1994 | 7531922 |
| molecular mimicry, anti-coxsackievirus b3 neutralizing monoclonal antibodies, and myocarditis. | molecular mimicry has been suggested as one mechanism to explain chronic myocarditis in some murine strains in the postinfectious period following induction of acute myocarditis by coxsackievirus b3 (cvb3). to test this hypothesis, neutralizing mabs were generated against a highly myocarditic cvb3 virus (cvb3m). these mabs neutralized several myocarditic and amyocarditic cvb3 variants by cytopathic effects inhibition assays. data from several experiments suggest that these mabs recognize discont ... | 1995 | 7533190 |
| echovirus 1 interaction with the isolated vla-2 i domain. | the isolated i domain of the integrin vla-2, produced as a bacterial fusion protein, specifically bound echovirus 1 and prevented virus attachment to cells. these results demonstrate that the receptor structures critical for virus attachment are contained solely within the vla-2 i domain and that soluble receptor fragments are capable of preventing infection. | 1995 | 7535868 |
| transient elevation of granulocyte colony-stimulating factor levels in cerebrospinal fluid at the initial stage of aseptic meningitis in children. | at the early stage of aseptic meningitis, there is a transient increase in neutrophil counts in the cerebrospinal fluid. some factors in the cerebrospinal fluid might induce migration of neutrophils into the cerebrospinal fluid. granulocyte colony-stimulating factor (g-csf) plays an important role, not only as a hemopoietic factor but also as a regulating factor for a biologic defense system by neutrophils in the foci of infection. to analyze the role of g-csf on accumulating neutrophils in the ... | 1995 | 7537365 |
| coxsackieviruses b1, b3, and b5 use decay accelerating factor as a receptor for cell attachment. | receptor binding and subsequent cell-mediated internalization or disassembly are the initial steps in virus replication. cell surface molecules that participate in this process are the primary determinants of virus tissue tropism. monoclonal antibody blockade, immunoprecipitation, and dna transfection were used to identify decay accelerating factor as a major cell attachment receptor for coxsackieviruses b1, b3, and b5. however, expression of human decay acceleration factor on the surface of non ... | 1995 | 7538177 |
| detection of picornavirus genomic and template rna strands by a novel semi-nested polymerase chain reaction-technique and agarose-gel electrophoresis. | attempts to evaluate the relative levels of enteroviral genomic and template rna strands in small biopsy tissue samples from patients have yielded ambiguous data, largely due to the limited amount of rna available. a novel semi-nested polymerase chain reaction (pcr) technique was developed to enable rna levels to be examined more accurately. pcr products were visualised by horizontal agarose gel electrophoresis. this technique was demonstrated on linear single-stranded plasmid dna; viral rna iso ... | 1995 | 7541748 |
| characterization of the echovirus 7 receptor: domains of cd55 critical for virus binding. | cd55, or decay-accelerating factor (daf), is a cell surface glycoprotein which regulates complement activity by accelerating the decay of c3/c5 convertases. recently, we and others have established that this molecule acts as a cellular receptor for echovirus 7 and related viruses. daf consists of five domains: four short consensus repeats (scrs) and a serine/threonine-rich region, attached to the cell surface by a glycosylphosphatidyl inositol anchor. chinese hamster ovary cells stably transfect ... | 1995 | 7543583 |
| coxsackie virus and diabetes revisited. | 1995 | 7585050 | |
| deficient diet evokes nasty heart virus. | 1995 | 7585080 | |
| rapid genomic evolution of a non-virulent coxsackievirus b3 in selenium-deficient mice results in selection of identical virulent isolates. | previous work from our laboratory demonstrated that selenium deficiency in the mouse allows a normally benign (amyocarditic) cloned and sequenced coxackievirus to cause significant heart damage. furthermore, coxsackievirus recovered from the hearts of selenium-deficient mice inoculated into selenium-adequate mice still induced significant heart damage, suggesting that the amyocarditic coxsackievirus had mutated to a virulent phenotype. here we report that sequence analysis revealed six nucleotid ... | 1995 | 7585090 |
| henoch-schonlein purpura associated with coxsackie-virus b1 infection. | 1995 | 7586994 | |
| comparison of coxsackie b neutralisation and enteroviral pcr in chronic fatigue patients. | coxsackie b enteroviruses have been implicated repeatedly as agents associated with chronic fatigue syndrome (cfs). the objective of this study was to compare the serological evidence for the presence of coxsackie b virus neutralising antibody, with the polymerase chain reaction (pcr) detecting a portion of the 5' nontranslated region (ntr) of the enterovirus genome. serum samples from 100 chronic fatigue patients and from 100 healthy comparison patients were used in this study. in the cfs study ... | 1995 | 7595406 |
| [the molecular pathogenesis of enterovirus myocarditis. virus persistence and chronic inflammation]. | 1995 | 7601616 | |
| inhibition of herpes simplex virus type 1, respiratory syncytial virus and echovirus type 11 by peroxidase-generated hypothiocyanite. | the human mouth is an important route of viral transmission and evidence exists that human saliva can neutralize some viruses, e.g. herpes simplex type 1 (hsv-1) and human immunodeficiency virus (hiv) in vitro. however, little is known of the actual antiviral agents in saliva. we have analyzed how hypothiocyanite (hoscn/-oscn) ions, present in human saliva and generated by salivary peroxidase systems, affect the viability of three different types of viruses; hsv-1 (capable of inducing oral lesio ... | 1995 | 7605114 |
| a single amino acid substitution in the capsid protein vp1 of coxsackievirus b3 (cvb3) alters plaque phenotype in vero cells but not cardiovirulence in a mouse model. | we previously described a large plaque attenuant (p14v-1) derived from a cardiovirulent coxsackievirus b3 (cvb3) and showed that there were no major determinants of either attenuation or plaque phenotype in the 5' nontranslated region (5'ntr). part of the region encoding the last 124 amino acids of vp3 and the first 106 amino acids of vp1 of the attenuant was then sequenced and compared to the wild-type. three nucleotide changes were found in the vp1 coding region: a silent single base change at ... | 1995 | 7605207 |
| analysis of protein synthesis by two-dimensional gel electrophoresis in t cells persistently infected with coxsackie b virus. | coxsackie b viruses (cbv) have been implicated in various human diseases that present as either limited acute infections or prolonged chronic infections. a number of investigations have suggested that a virus-induced immune dysfunction might play a role in in vivo pathogenesis. in the current study, we describe cbv infection of two human t cell-derived cell lines (jurkat and molt-4 cells) as potential models for cbv infection of lymphocytes. short term (up to 144 h post-infection) cbv infection ... | 1995 | 7607163 |
| shigella flexneri adherence to and multiplication in coxsackie b1 virus-infected hep-2 cells. | coxsackie b1 virus infection enhances the susceptibility of in vitro cultured hep-2 cells to invasiveness by shigella flexneri. we have studied the effect of viral infection on two phases of the invasiveness. only a minor part was mediated by enhanced bacterial adherence to the cells, and the intracellular multiplication was unaffected by the virus. enhanced adherence was not dependent on the presence of the gene product of the 140 md virulence associated plasmid. our data indicate that enhanced ... | 1995 | 7612255 |
| coxsackie b virus infection and onset of childhood diabetes. | infection with coxsackie b viruses has been linked to insulin-dependent diabetes mellitus. nine of 14 serum samples (64%) taken from children at the onset of diabetes were positive for enterovirus rna by pcr. all of the children were under age six, and five were under age three. by contrast, enterovirus sequences were detected in only two of 45 serum samples from appropriate comparison children (4%). sequences from six of the positive patients showed strong homology with coxsackie b3 and b4 viru ... | 1995 | 7616803 |
| comparison of pcr and cell culture for detection of enteroviruses in sludge-amended field soils and determination of their transport. | pcr and cell culture assays for enteroviruses were conducted on soil samples collected from an experimental farm that had received mesophilic anaerobically digested sludge for the past 7 years. of 24 samples assayed, 21 samples were positive by pcr, implying that at least some viral nucleic acid sequences remained intact. however, these viral particles were unable to infect the buffalo green monkey cell line used in subsequent cell culture assays. it is significant that positive pcr detection of ... | 1995 | 7646051 |
| therapy with immunoglobulin suppresses myocarditis in a murine coxsackievirus b3 model. antiviral and anti-inflammatory effects. | the treatment of some inflammatory diseases (eg, kawasaki disease) with immunoglobulin has been demonstrated to be effective. accordingly, to elucidate the mechanism underlying such actions of immunoglobulin, we examined its effects on murine coxsackievirus b3 (cb3) myocarditis. | 1995 | 7664447 |
| gamma/delta t lymphocytes in viral infections. | t lymphocyte progenitors differentiate into two distinct t cell lineages. although the alpha beta and gamma delta t cell lineages resemble each other phenotypically and functionally, there are some striking differences. some gamma delta t cells recognize, similarly to alpha beta t cells, peptides presented by major histocompatibility complex (mhc) proteins or mhc-like molecules. however, there are gamma delta t cells that recognize mhc molecules in a fundamentally different manner in comparison ... | 1995 | 7665983 |
| requirement of mip-1 alpha for an inflammatory response to viral infection. | macrophage inflammatory protein-1 alpha (mip-1 alpha) is a chemokine that has pro-inflammatory and stem cell inhibitory activities in vitro. its biologic role in vivo was examined in mice in which the gene encoding mip-1 alpha had been disrupted. homozygous mip-1 alpha mutant (-/-) mice were resistant to coxsackievirus-induced myocarditis seen in infected wild-type (+/+) mice. influenza virus-infected -/- mice had reduced pneumonitis and delayed clearance of the virus compared with infected +/+ ... | 1995 | 7667639 |
| differential diagnosis and genetic analysis of the antigenically related swine vesicular disease virus and coxsackie viruses. | monoclonal antibodies directed against an isolate of swine vesicular disease virus (svdv), characterized by virus neutralization tests and competition assays, were used to compare svdv isolates and isolates of the antigenically related coxsackie viruses by elisa. svdv-specific reaction patterns and one specific for coxsackie viruses were observed. this provided a method for distinguishing between these enteroviruses. in addition, rt-pcrs were undertaken with coxsackie virus and svdv genomes. dif ... | 1995 | 7673387 |
| t lymphocyte responses in cvb3-induced murine myocarditis. | three monoclonal antibodies (mab) to group a streptococcus m5 serotype (mab 36.2.2, 49.8.9 and 54.2.8) cross-reactivity bind to various heart antigens (including myosin, tropomyosin and vimentin) and neutralize a myocarditic variant of coxsackievirus b-3 (nancy) (cvb3). the existence of shared antigenic epitopes between the two distinct infectious agents and the heart implies that antigenic mimicry may form the foundation of the autoimmune response. plaque purified variants of cvb3 were isolated ... | 1993 | 7685923 |
| the integrin vla-2 binds echovirus 1 and extracellular matrix ligands by different mechanisms. | the integrin vla-2 mediates cell adhesion to collagen and laminin and also functions as a virus receptor, mediating cell surface attachment and infection by a human pathogen, echovirus 1. to determine whether extracellular matrix proteins and virus interact with vla-2 in the same manner, we carried out a detailed comparison of these two functions and found that they differed markedly in six different respects. in contrast to the ecm/vla-2 interaction, echovirus 1 binding did not discriminate bet ... | 1993 | 7686920 |
| mapping of antigenic determinants of the adenine-nucleotide translocator and coxsackie b3 virus with synthetic peptides: use for the diagnosis of viral heart disease. | 1993 | 7689426 | |
| [effect and mechanism of astragalus membranaceus on coxsackie b3 virus rna in mice]. | using balb/c mice infected with coxsackie virus b3 (cvb3) as a model, the effect of astragalus membranaceus (am) on cvb3-rna has been observed in myocardial tissues of mice by rna-rna in situ hybridization with negative-strand rna probes leballing with 35s and quantitative imaging analysis of positive hybridization signals. the mechanism of its effect on cvb3-rna has also been investigated by induction with am and detection of beta-interferon (beta-ifn). results showed that the copy numbers of c ... | 1994 | 7703635 |
| epidemics of aseptic meningitis due to echovirus 30 in japan. a report of the national epidemiological surveillance of infectious agents in japan. | two rages of epidemic of aseptic meningitis (am) due to echovirus 30 (e30) in japan were analyzed with respect to two sources of information, am incidence and e30 isolation, both gathered through the national epidemiological surveillance of infectious diseases. the first e30 epidemic spread throughout japan in 1983 and ceased within the year. the second epidemic, starting in 1989, continued for the three successive years, and in the last year, 1991, the total e30 reports numbered 4,061, the larg ... | 1994 | 7715095 |
| in vitro infection of mouse pancreatic islet cells with coxsackie viruses. | we have demonstrated the ability of 4 standard coxsackie viruses (b4, b5, a7, and a9) and one fresh isolate (a7) from a newly diabetic child with homologous serological response, to infect in vitro grown mouse pancreatic islet cells. up to the 9th day after infection the multiplication of viruses in the cells was proved using virus titration and immunofluorescence test. isolated pancreatic cells proved to be a suitable model for detailed studies of experimental infection of pancreatic cells with ... | 1994 | 7725998 |
| replication and persistence of coxsackieviruses b3 in human fibroblasts. | although in some cases a carrier state of coxsackieviruses in human fibroblasts was described, the persistence mechanism has remained unknown. our results demonstrate a replication of coxsackievirus b3 (cvb3) in diploid human fibroblasts that is dependent on the virus strain as well as on the cell line involved. two cvb3 nancy strains could be multiplied over more than 10 passages in cell line h, whereas cvb3 strains sh"c" and sh"w" did not longer form infectious virus following several passages ... | 1995 | 7734835 |
| acute fulminant, fatal coxsackie b virus infection: a report of two cases. | within a space of four months, between march to june 1993, medico-legal autopsies on 9 sudden infant deaths from natural causes were conducted at the department of forensic medicine. of these, 6 were due to unspecified interstitial pneumonitis or myocarditis (consistent with viral aetiologies), while 1 was attributed to adenovirus infection. the remaining 2 were due to fulminant coxsackie virus (type b1) infection, where the post-mortem findings included leptomeningitis, myocarditis, florid inte ... | 1994 | 7741514 |
| efficacy of a polyvalent inactivated-virus vaccine in protecting mice from infection with clinical strains of group b coxsackieviruses. | a polyvalent vaccine developed from formalin-inactivated prototype strains of coxsackieviruses group b1-6 was tested for its ability to protect mice from acute infection with clinical strains. adolescent male cd1 mice received an intraperitoneal injection, repeated once or twice at 8 day intervals, containing 0.3 ml placebo or vaccine. eight days after the final dose of vaccine, groups of 4 mice were challenged with 1 x 10(4) plaque-forming units of a test strain of group b coxsackievirus, and k ... | 1994 | 7747099 |
| pathogenesis of virus-induced diabetes in mice. | male cd-1 mice were challenged with a diabetogenic strain (e2) of coxsackievirus b4 (cvb4). at 7 weeks, 6 months, and 1 year after inoculation, mean histopathologic scores, postprandial blood glucose levels, and serum levels of antibody to islet cells were significantly elevated and mean fasting serum insulin levels significantly reduced in infected mice versus uninfected controls (p < .001 for each). at 7 weeks after infection, viral rna, but not protein or infectious virus, was demonstrated in ... | 1995 | 7751687 |
| the genome of echovirus 11. | echoviruses are the largest enterovirus subgroup consisting of 32 serotypes. they are common human pathogens causing, for example, meningitis, encephalitis and exanthema, but in spite of their clinical importance, relatively little is known about their biology. to illuminate the molecular characteristics of echoviruses, we have completed the genomic sequence of serotype 11. the rna genome is 7438 nucleotides in length and it codes for a 2195 amino acid long polyprotein. when compared to other se ... | 1995 | 7762294 |
| intrauterine coxsackie virus, group b type 1, infection: viral cultivation from amniotic fluid in the third trimester. | we report a case that presents clear evidence of an intrauterine infection of twin fetuses with an enterovirus. the mother had signs and symptoms of chorioamniotitis at 34 weeks' gestation. coxsackie virus, group b type 1 (cvb1), was cultured from amniotic fluid obtained by transabdominal amniocentesis when the membranes of both fetuses were still intact. delivery occurred vaginally approximately 24 hours later, following spontaneous rupture of membranes. at birth, both twins showed signs of sep ... | 1995 | 7779200 |
| receptor proteins on newborn balb/c mouse brain cells for coxsackievirus b3 are immunologically distinct from those on hela cells. | newborn balb/c mice are highly susceptible to infection by the six coxsackievirus serotypes of group b (cvb) and it is known that receptor for these viruses are in highest concentration in the brain as compared to other tissues. therefore, proteins from the brain tissues of these animals were solubilized (brain-ext) and characterized for the identification of mouse brain receptor (mbr) proteins. virus-blot analyses of brain-ext suggested that each of three virus variants of cvb3-(n, w and rd) re ... | 1995 | 7785319 |
| [standardization of an inhibition elisa technique for the serologic diagnosis of coxsackie virus group b infections]. | an inhibition elisa technic to detect antibodies aimed at coxsackie b viruses was standardized. the method was type-specific since it could detect antibodies to 4 coxsackie b serotypes (it wasn't tried on serotypes b2 and b4 because the strains were not available). the comparison with the neutralization technic showed 85% coincidence, 91% sensitivity and 82% specificity. all the reactives used in the assay were produced in our laboratory. | 1993 | 7800894 |
| integrin alpha 2 cytoplasmic domain deletion effects: loss of adhesive activity parallels ligand-independent recruitment into focal adhesions. | chinese hamster ovary (cho) cells transfected with the integrin alpha 2 subunit formed a stable vla-2 heterodimer that mediated cell adhesion to collagen. within cho cells spread on collagen, but not fibronectin, wild-type alpha 2 subunit localized into focal adhesion complexes (facs). in contrast, alpha 2 with a deleted cytoplasmic domain was recruited into facs whether cho cells were spread on collagen or fibronectin. thus, as previously seen for other integrins, the alpha 2 cytoplasmic domain ... | 1994 | 7841525 |
| the i domain is essential for echovirus 1 interaction with vla-2. | vla-2, the alpha 2 beta 1 integrin, mediates cell adhesion to collagen and laminin, and is the receptor for the human pathogen echovirus 1. because of its similarity to domains present in other proteins that interact with collagen, a 191 amino acid region within the alpha 2 subunit (the i domain) has been proposed as a potential site for ligand interactions. although the alpha 2 subunits of human and murine vla-2 are 84% identical, human alpha 2 promotes virus binding whereas murine alpha 2 does ... | 1994 | 7842258 |
| coxsackievirus b3 entry into the host cell interferes with g-protein-mediated transmembrane signalling. | in the present work we used various cell lines in order to study the possible effect of coxsackievirus b3 (cvb3) entry on the adenylyl cyclase transmembrane signalling system. a significant decrease (by about 10-20%) was found in forskolin-augmented as well as in a1f-4- and gtp gamma s-sensitive adenylyl cyclase activity in plasma membranes isolated from hela, hep-2, vero and green monkey kidney cells shortly (up to 60 min) preincubated with cvb3 (5 pfu/cell). moreover, the ability of g-proteins ... | 1994 | 7849242 |
| incidence of coxsackie (b) virus infection in diabetics. | 45 diabetic patients were screened for raised titres against coxsackie group of viruses. 11 diabetic patients showed raised titres of neutralising antibodies against one of the coxsackie group of viruses, as against 3 in 25 controls. | 1994 | 7883670 |
| coxsackie b1 virus-induced murine myositis: a correlative study of muscular lesions and serological changes. | we investigated the role of humoral factors in the pathogenesis of coxsackie b1 virus-induced murine myositis (cb1-myositis). at 2, 4 and 8 weeks after inoculation, serum was studied for circulating immune complexes (cic) (raji-cell assay), haemolytic complement activity (ch50 titre) and anticytoplasmic autoantibodies (western blotting, immunoprecipitation) in relation to degree of mononuclear cell infiltration and muscle fibre necrosis. at 2, 4 and 8 weeks, cell infiltration correlated positive ... | 1994 | 7888031 |
| complete nucleotide sequence of a strain of coxsackie b4 virus of human origin that induces diabetes in mice and its comparison with nondiabetogenic coxsackie b4 jbv strain. | the e2 strain of coxsackie b4 virus (cb4), which is of human origin, can induce a diabetes-like syndrome in mice. the cdna of the genome of the e2 strain was cloned and sequenced. the e2 viral genome was found to comprise 7,396 bases, which appear to encode a polyprotein of 2,183 amino acids with an overall similarity of 94.91% to nondiabetogenic cb4 prototype jbv strain. the e2 genome is organized like other enteroviruses. it has a 5' noncoding region of 744 nucleotides, a single long open tran ... | 1994 | 7897366 |
| sequence homology of the diabetes-associated autoantigen glutamate decarboxylase with coxsackie b4-2c protein and heat shock protein 60 mediates no molecular mimicry of autoantibodies. | molecular mimicry between viral antigens and host proteins was often suggested to be involved in induction of autoimmune diseases. in type 1 diabetes where pancreatic beta cells are destroyed by autoimmune phenomena, a linear sequence homology between a major autoantigen, glutamate decarboxylase (gad), and the 2c protein of coxsackie b4 was identified. in addition, a sequence homology between gad and the mycobacterial heat shock protein 60 was described and the suggestions were made that molecul ... | 1994 | 7913951 |
| absence of coxsackie viruses in idiopathic inflammatory muscle disease by in situ hybridization. | the role of coxsackie virus infection in the pathogenesis of idiopathic inflammatory muscle disease (iimd) has been investigated by many workers with conflicting results. this study uses in situ hybridization, with digoxigenin-labelled oligonucleotide probes complementary to the coxsackie b virus genome, to investigate the presence of virus rna in muscle biopsies from 26 patients with iimd. in the five cases of inclusion body myositis studied, there was focal probe-binding to nuclei and cytoplas ... | 1994 | 7936073 |
| replication of echo virus type 25 jv-4 reference strain and wild type strains in mrc5 cells compared with that of poliovirus type 1. | in echo virus type 25/jv-4 the shut off of host cell protein synthesis took significantly longer and the kinetics of the synthesis of viral proteins and viral rna occurred much later than in the poliovirus. however, these characteristics impaired neither polyprotein processing nor virus production in the jv-4 strain. in contrast the two wild strains m.1262 and th.222 had a lower virus yield than strain jv-4. the presence of a high mr protein in the pattern of viral proteins of wild strains sugge ... | 1994 | 7944954 |
| [effect of astragalus membranaceus on electrophysiological activities of acute experimental coxsackie b3 viral myocarditis in mice]. | a murine model for observing the effect of astragalus membranaceus (am) on electrophysiological activity of the right ventricular myocardium was developed in 4 week-old male balb/c mice infected with coxsackie b3 virus (cb3v). the conventional microelectrode technique and real-time microcomputer data processor system was used. the survival rate in infected-am treated mice was significantly higher and the percentage of abnormal action potential was much lower than those in control mice (p < 0.05 ... | 1994 | 7950216 |
| nucleotide sequencing of pcr products shows the presence of coxsackie-b3 virus in endomyocardial biopsies from patients with myocarditis or dilated cardiomyopathy. | 1994 | 7958242 | |
| persistence of replicating coxsackievirus b3 in the athymic murine heart is associated with development of myocarditic lesions. | coxsackievirus b3 (cvb3)-induced myocarditis was studied in euthymic (nu/+) and athymic (nu/nu) c3h/hen (h-2k) mice. mice were inoculated intraperitoneally with 10(6) p.f.u. of cvb3 (nancy strain) and sacrificed at intervals up to 92 days post-inoculation (p.i.). viraemia peaked at day 2 to 3 p.i. and ceased at day 5 to 7 p.i. in a synchronized manner in both sets of mice. very few infectious particles were detected in the blood of nu/nu mice after day 14 p.i. in nu/nu mice, cvb3 persisted in my ... | 1994 | 7964602 |
| molecular and biological characteristics of echovirus 22, a representative of a new picornavirus group. | recent sequence analysis revealed that the human pathogen echovirus 22 (ev22) is genetically distant from all the other picornaviruses studied to date (t. hyypiä, c. horsnell, m. maaronen, m. khan, n. kalkkinen, p. auvinen, l. kinnunen, and g. stanway, proc. natl. acad. sci. usa 89:8847-8851, 1992). we have further characterized the biological properties of the virus and show here that the virion has properties similar to those of other picornaviruses. however, the protein composition is unique, ... | 1994 | 7966616 |
| comparison of methods to detect enteroviral genome in frozen and fixed myocardium by polymerase chain reaction. | understanding the pathogenesis of viral myocarditis is linked to the availability of sensitive assays to detect viral genome in clinical material. recent advances in molecular techniques permit detection of viral-specific rna in tissue samples. we describe here a comparison of different methods for rna extraction, reverse transcription, and gene amplification of coxsackievirus b3 virus in fixed and frozen mouse myocardium. | 1994 | 7967516 |
| impaired ca2+ response to glucose in mouse beta-cells infected with coxsackie b or echo virus. | five strains of coxsackie b4 virus and one of echo 11 virus were tested with regard to their ability to replicate in pancreatic mouse beta-cells and interfere with the alterations of the cytoplasmic ca2+ concentration ([ca2+]i) induced by glucose. all strains except one both multiplied and caused cytopathic effect. in a control group 68% of the beta-cells responded to 11 mm glucose with large amplitude oscillations of [ca2+]i. after inoculation with the infectious strains these oscillations appe ... | 1994 | 7985410 |
| the effect of subsequent myocardial damage on the expression of coxsackievirus b4 myocarditis and the development of ventricular aneurysms. | coxsackievirus b (cb) 4 causes transmural myocarditis in suckling mice with ensuing development of focal ventricular thinning or aneurysms. we studied whether subsequent infection with another cardiotropic virus influences the expression of cb4 disease. cb4 infection was established in 2-day-old cd1 mice by intraperitoneal (ip) inoculation. three weeks later, surviving animals were randomized to receive cb3 or saline ip. they were then killed over a 45-day period. cb4 neutralizing antibody (na) ... | 1994 | 7988609 |
| [the antiviral properties of 4-iodoantipyrine in an experimental enterovirus infection]. | the studies of the therapeutic and prophylactic action of a compound from the group of nonsteroid antiinflammatory substances, iodantipyrine-4, in newborn white mice infected with coxsackie b3 virus showed the drug to possess both therapeutic and prophylactic activity in the acute period of infection. | 1994 | 7998400 |
| [the isolation and characteristics of monoclonal antibodies to the structural proteins of coxsackie b5 virus]. | five hybridomas secreting monoclonal antibodies (mca) to coxsackie b5 virus were generated by fusion of sp2/0 myeloma cells with balb/c mouse immune splenocytes. most mca belonged to the igg and one to the igm class. out of 4 mca binding the structural protein vp2, two mca showed type specificity in neutralization test and cross-reactivity with other enteroviruses, one mca reacted with all enteroviruses tested, and the one showing type specificity among coxsackie b group "recognized" an epitope ... | 1994 | 8017060 |
| sequences specific for enterovirus detected in spinal cord from patients with motor neurone disease. | to investigate the association of enteroviruses with motor neurone disease, also known as amyotrophic lateral sclerosis. | 1994 | 8019310 |
| coxsackievirus b3 infection alters the uptake of 2,3,7,8-tetrachlorodibenzo-p-dioxin into various tissues of the mouse. | the tissue uptake of 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) during infection was studied in a mouse model using the common human virus coxsackievirus b3 (cb3), adapted here to the mouse. male a/j-mice were infected with the cb3 virus and subsequently, on days 4 and 7 of the infection, injected with 0.5 microci [14c]tcdd (about 65 micrograms/kg). an uninfected group was injected with [14c]tcdd and served as the control group. spleen, thymus, heart, pancreas, liver and brain were dissected 24 ... | 1994 | 8023340 |
| effect of astragalus membranaceus on electrophysiological activities of acute experimental coxsackie b-3 viral myocarditis in mice. | a murine model for observing the effect of astragalus membranaceus (am) on electrophysiological action of the right ventricular myocardium was developed in 4-week-old male balb/c mice infected with coxsackie b-3 virus (cb3v). the conventional microelectrode technique and a real-time data processor system were used. the survival rate in am-treated mice was much higher and the percentage of abnormal action potential was much lower than those in infected control mice (p < 0.05, p < 0.01, respective ... | 1993 | 8032064 |
| increased virulence of a human enterovirus (coxsackievirus b3) in selenium-deficient mice. | coxsackievirus b3 (cvb3/20)-induced myocarditic lesions occurred more quickly and were more severe and virus titers in heart and liver were higher in selenium (se)-deficient than se-adequate mice. nk cell activity and serum neutralizing antibody titers were similar in both se-adequate and -deficient cvb3/20-infected mice; however, lymphocyte proliferation to both mitogen and antigen was decreased in se-deficient mice. cvb3/20 isolated from se-deficient donor mice and inoculated into se-adequate ... | 1994 | 8035022 |
| coxsackievirus b3 infection in human leukocytes and lymphoid cell lines. | although coxsackie b viruses (cbvs) are known to cause viremia during acute infection, the role of the blood cells as a target for virus replication is poorly understood. we have analyzed the susceptibility of human peripheral blood mononuclear cells (pbmcs), granulocytes, bone marrow (bm) cells, and lymphoid cell lines to coxsackievirus b3 infection. lymphoid cell lines with b- and t-cell characteristics (raji and molt-4, respectively) supported virus replication to high titers and virus protei ... | 1994 | 8043865 |
| complete nucleotide sequence of a beta-cell tropic variant of coxsackievirus b4. | a mouse pancreas-adapted variant of coxsackievirus b4 (p-cb4) has been shown to replicate in, and cause an excessive release of insulin from, pancreatic beta cells cultured in vitro. the prototype cb4 strain (jvb benschoten), from which the adapted variant was derived, although able to replicate in cultured islets does not cause a similar release of insulin from the beta cells. the pancreas-adapted virus has also been shown to cause host cell protein synthesis shut-off in beta cells and to inhib ... | 1994 | 8046427 |
| acute severe rhabdomyolysis in an human immunodeficiency virus-seropositive patient associated with rising anti-coxsackie b viral titers. | very recently there have been sporadic reports of polymyositis in patients who are positive for human immunodeficiency virus (hiv). the cause of this condition has not been documented. recent evidence has been presented which indicates that the coxsackie b virus may be a causative factor. presentation is made of a patient, a drug abuser who was found to be hiv-positive with severe polymyositis manifested by generalized muscle weakness and a total serum creatinine kinase that reached the unusuall ... | 1994 | 8048800 |
| investigation of the coxsackievirus b3 nonstructural proteins 2b, 2c, and 3ab: generation of specific polyclonal antisera and detection of replicating virus in infected tissue. | the coxsackievirus b3 (cvb3) nonstructural proteins 2b and 3ab were synthesized as beta-galactosidase fusion proteins in e. coli in order to generate specific polyclonal antisera. 2b and 3ab fusion proteins were purified by preparative sds-polyacrylamide gel electrophoresis and inoculated into rabbits. protein 2c-specific antiserum was produced using synthetic oligopeptides which were defined by computer based amino acid sequence analysis. specificity of the generated antisera was analysed by im ... | 1994 | 8071417 |
| [an outbreak of coxsackie b enteroviral infection in children]. | an outbreak is described of enteroviral infection caused by coxsackie b5 virus, among the children at the health camp for children. specific features of the clinical picture in the sick include an acute beginning, of the illness respiratory catarrh, exanthema in two patients, general intoxication, lymphadenopathy and renal lesion presenting as acute glomerulonephritis with hematuric syndrome. | 1994 | 8073729 |
| [the correction of a secondary immunological deficit caused by the coxsackie b3 virus by using an immunomodulator of bacterial origin]. | 1993 | 8079587 |