Publications

animal models for evaluating the myelosuppressive effects of cancer chemotherapeutic agents.	an important objective of new anticancer drug discovery programs is identification of agents that are less myelosuppressive than those currently available. we have developed several animal models to evaluate these drugs for myelosuppression. our screening model measures changes in neutrophil counts in mice as an indicator of myelosuppression. this model correctly predicted the myelosuppressive effects of 13 (76%) of 17 known agents. cisplatin, carboplatin, spiroplatin, and marcellomycin caused n ...	1985	3987834
idiopathic hypersplenism in a ferret.	a 3-year-old spayed female ferret was examined because of mild icterus and massive splenomegaly. pancytopenia was diagnosed and was unaffected by blood transfusion or corticosteroid therapy. splenectomy resulted in resolution of clinical signs, with survival up to 20 months after surgery. histologic examination of the spleen revealed areas of splenic necrosis and severe extramedullary hematopoiesis. the final diagnosis, based on exclusion of other causes of splenomegaly and pancytopenia, was idi ...	1985	3988601
disseminated cutaneous squamous cell carcinoma in a ferret.	a 3-year-old male ferret was admitted with ulcerated nodules and fistulous draining tracts on the pads and digits of the right front and left hind feet. proteus sp and escherichia coli were isolated from the exudate. histologic examinations revealed that all skin lesions were associated with an underlying squamous cell carcinoma. surgical removal was attempted, followed by chemotherapy. regression of remaining lesions was noted before discharge; however, the ferret died 5 days later and was not ...	1985	3988603
analysis of antigenic relationships among influenza virus strains using a taxonomic cluster procedure. comparison of three kinds of antibody preparations.	hemagglutination inhibiting (hi) monoclonal antibody preparations (ma) were raised against six influenza a (h3n2) strains from the period 1977-1982. twenty-three hybridomas were selected and titrated in hi assays against these strains and against 18 influenza a (h3n2) viruses isolated in the netherlands during the seasons 1981-1982 and 1982-1983. similar hi tests were performed with conventional post-infection ferret antisera and with ferret antisera adsorbed with heterologous strains of influen ...	1985	3988875
a nuclear magnetic resonance study of metabolism in the ferret heart during hypoxia and inhibition of glycolysis.	31p nuclear magnetic resonance was used to measure the relative concentrations of phosphorus-containing metabolites in langendorff-perfused ferret hearts. intracellular concentrations of inorganic phosphate ([pi]i), phosphocreatine ([pcr]i), atp ([atp]i) and h+ (phi) were monitored under control conditions and while oxidative phosphorylation and/or glycolysis were prevented. mechanical performance was assessed by recording the pressure developed in a balloon placed in the left ventricle. oxidati ...	1985	3989725
the role of intracellular [ca2+] and [h+] in contractile failure of the hypoxic heart.	when oxidative metabolism is inhibited in heart muscle, developed tension often increases slightly before decreasing below control. we have examined the possible mechanisms underlying these changes in developed tension in two series of experiments. in the first series of experiments, the photoprotein aequorin was used to monitor intracellular free [ca2+] [( ca2+]i) in papillary muscles during inhibition of oxidative phosphorylation, using either cyanide or hypoxia. the observed changes of develo ...	1985	3992041
the influence of retinal afferents upon the development of layers in the dorsal lateral geniculate nucleus of mustelids.	the extent to which the development of a normal laminated lateral geniculate nucleus depends upon retinal afferents has been studied in normal and albino ferrets and in mink. removal of all retinal afferents before they invade the nucleus (28 days in utero) or before they establish distinct monocular terminal fields (newborn, approximately 41 days post-conception) produces a nucleus that is smaller than normal and poorly separated from the adjacent perigeniculate and medial interlaminar nuclei. ...	1985	3998826
the effects of cyanide and its interactions with norepinephrine on isolated aorta strips from the rabbit, dog, and ferret.	effects of sodium cyanide on isolated strips of rabbit, dog, and ferret aorta were determined. in the rabbit aorta strip, cumulatively added cyanide caused small contractions beginning at approximately 10(-11) m cyanide and reaching a maximum response at 10(-5) m. a concentration of cyanide between 10(-5) m and 10(-3) m produced relaxation. when cyanide was cumulatively added to norepinephrine (ne)-contracted rabbit aorta strips, no contractions were observed. cyanide concentrations above 10(-5) ...	1985	4002238
interaction between a normoxic and a hypoxic region of guinea pig and ferret papillary muscles.	papillary muscles were mounted in a three-compartment bath. the tip of the muscle was exposed to hypoxic and glucose-free solution. the other parts of the preparation were superfused with tyrode's solution, building a free-flow border between hypoxic and normoxic superfusates. the normoxic part of the bath was subdivided by a rubber membrane so that current pulses could be applied between segments of the preparation. signs of electrotonic interaction between normoxic and hypoxic parts were obser ...	1985	4006096
frequency-dependent depression of myocardial contractility by slow calcium channel blocking drugs.	the negative inotropic effects of two dihydropyridine and two non-dihydropyridine calcium slow channel blocking drugs were studied using ferret isolated papillary muscle preparations contracting both isotonically and isometrically. the degree of inotropic depression was found to be dependent on the frequency of stimulation for all four agents. frequency dependence of inotropic effect was of the order: nifedipine less than felodipine less than diltiazem less than verapamil.	1985	4007049
severity of fever in influenza: studies on the relation between viral surface antigens, pyrexia, level of nasal virus and inflammatory response in the ferret.	previous work has shown that fever in influenza of ferrets occurs following release of endogenous pyrogen from virus-phagocyte interaction in the upper respiratory tract (urt), and suggested that the poor inflammatory response and correspondingly low fever elicited by a/puerto rico/8/34 (h1n1), compared with h3n2 reassortant clones of a/puerto rico/8/34-a/england/939/69, were related to its h1 and n1 surface antigens. nasal virus levels, inflammatory and pyrexial responses produced in ferrets by ...	1985	4020349
characteristics of the vagally driven non-adrenergic, non-cholinergic inhibitory innervation of ferret gastric corpus.	this paper reports a quantitative in vivo study on the vagal activation of the intramural non-adrenergic, non-cholinergic inhibitory nerves in the ferret gastric corpus. the nature of the inhibitory neurotransmitter was also investigated. in the atropinized, guanethidine-treated, urethane-anaesthetized ferret, electrical stimulation (10 s at 20 v, 1-20 hz, 0.5 ms pulses) of the cervical vagi produced a prompt fall in intracorpus pressure that was related to the stimulus frequency. the maximal re ...	1985	4020696
ultrastructure of the stomach of the small short-tailed shrew, blarina brevicauda c.	the normal gastric ultrastructure has been characterized for the small short-tailed shrew, blarina brevicauda c., which is a primitive eutherian and one of the smallest living mammals with extraordinarily high metabolic rate. in general the cell types present and cytologic character of gastric mucosal, submucosal, and muscularis cells were similar to that reported for other more advanced small mammalian species. chief cells, endocrine cells, and lamina proprial elements were morphologically iden ...	1985	4020920
ferrets in biomedical research.		1985	4021434
a comparative study of the tapetum, retina and skull of the ferret, dog and cat.	results of this investigation indicate that the ferret (mustela putorius) closely resembles the dog (canis familiaris) and should be a useful research animal alternative. the tapetum lucidum is a common structure present in the eyes of dogs, cats (felis catus) and other nocturnal animals. our study showed that this structure was present in ferret eyes. the color or reflection of the ferret and dog tapetum was remarkably reduced by the general fixation with glutaraldehyde. however, this color fad ...	1985	4021435
measles virus encephalitis in ferrets as a model for subacute sclerosing panencephalitis.	young adult ferrets were used as experimental animals to study subacute sclerosing panencephalitis (sspe). when cells infected with cell-associated measles virus strains isolated from sspe patients were inoculated intracerebrally (i.c.) into ferrets, they developed an acute encephalitis and died within 1 to 3 weeks without detectable antibody formation. immunization with live measles vaccine 5 weeks before i.c. inoculation changed the course of the infection in about 50% of the ferrets. these an ...	1985	4021436
the ferret as a model for inner ear research.	viral infections have long been suspected to be causative agents in a number of inner ear dysfunctions. with few exceptions, the virus has not been demonstrated as the direct agent leading to hearing loss and/or vertigo. selective inner ear changes have been observed recently in sensory and nonsensory epithelial cells in the ferret model for reye's syndrome after intranasal inoculation with influenza b combined with aspirin administration and the creation of an arginine deficiency. such findings ...	1985	4021437
pulmonary physiology of the ferret and its potential as a model for inhalation toxicology.	physiological measurements were made from anesthetized, tracheotomized, supine male ferrets. six animals weighing 576 +/- 12 g, had tidal volumes (vt) of 6.06 +/- 0.30 ml, respiratory frequencies (f) of 26.7 +/- 3.9 min(-1), dynamic lung compliance (cdyn) of 2.48 +/- 0.21 ml cmh2o(-1), pulmonary resistance (rl) of 22.56 +/- 1.61 cmh2o l(-1) sec. pressure-volume curves from nine ferrets (including the above six) revealed almost infinitely compliant chest walls so that lung and total respiratory s ...	1985	4021438
evaluation of ketamine, ketamine-xylazine and ketamine-diazepam anesthesia in the ferret.	ketamine, ketamine-xylazine, and ketamine-diazepam were evaluated clinically in 15 ferrets, and safe dosage was determined for each. all of the three regimens provided excellent immobilization. however, muscle rigidity and incomplete analgesia were noted in ketamine alone and in ketamine-diazepam respectively. it was concluded that 25 mg/kg ketamine and 2 mg/kg xylazine intramuscularly provided acceptable analgesia, muscle relaxation, duration and smooth recovery, although cardiac arrhythmias we ...	1985	4021439
adrenalectomy in the ferret.	a simple adrenalectomy technique is presented for the ferret (mustela putorius furo). the adrenal glands were removed in two operations with an interim recovery period of approximately 1 week. the right adrenal should be removed first, as the surgery is complicated on that side by fascia which binds the adrenal to the inferior vena cava. salt solution (1% nacl) in place of water will maintain sodium balance.	1985	4021440
restraint device for serial blood sampling of ferrets.	a device was designed that effectively restrained unanesthetized ferrets for serial blood sampling from the caudal artery. materials used for construction were inexpensive and easily obtained. fabrication was simple and rapid.	1985	4021441
a comparative study of complement activation.	antisera to sheep erythrocytes (e) were raised in cattle, rabbits, mice, hamsters, guinea-pigs, ferrets, badgers, hedgehogs and fowls. cross activation of total haemolytic complement (thca) examined all combinations of sensitized sheep e and normal sera (including human); kinetic assays examined the lysis of e sensitized with rabbit antibodies. from the same species, all combinations of normal serum and xenogeneic e were used to measure total alternative pathway activity (tapa); tapa was also ac ...	1985	4024450
recent h1n1 viruses (a/ussr/90/77, a/fiji/15899/83, a/firenze/13/83) replicate poorly in ferret bronchial epithelium. brief report.	three recent wild-type h1n1 influenza virus isolates (a/ussr/90/77, a/fiji/15899/83 and a/firenze/13/83) replicated poorly in organ cultures of ferret bronchial tissue compared with the replication of an h3n2 wild-type virus (a/england/939/69). all four viruses replicated well in nasal turbinate tissue. examination of one h1n1 virus (a/ussr/90/77) in vivo showed heavy infection in the upper respiratory tract of ferrets but little in the lower respiratory tract. these results raise the possibilit ...	1985	4026584
a demonstration of two distinct geniculocortical projection patterns in albino ferrets.	the geniculocortical pathways of albino ferrets have been studied by injecting lectin bound horseradish peroxidase into the visual cortex and then studying the geniculate distribution of retrogradely labelled cells in the dorsal lateral geniculate nucleus. it has been shown that in ferrets, as in siamese cats, there are two quite distinct patterns of geniculocortical projection. one of the patterns seen in ferrets is comparable to the 'midwestern' pattern previously described in siamese cats, wh ...	1985	4027667
the organization of the lateral geniculate nucleus and of the geniculocortical pathway that develops without retinal afferents.	the fine structure and cortical connections of the dorsal lateral geniculate nucleus have been studied in postnatal (3.5-14-month-old) ferrets in which all retinal afferents had been removed prenatally at the time these fibers are first starting to invade the nucleus. the synaptic profiles in the mature nucleus show the cytological characteristics and arrangements that would remain if the retinal afferents were removed, with no significant compensatory ingrowth of foreign specific afferents. the ...	1985	4027668
brugia malayi: intravenous injection of microfilariae in ferrets as an experimental method for occult filariasis.	microfilaremia, immune responses, and pathology were compared in ferrets infected with 100 third-stage larvae of brugia malayi (subperiodic strain) or injected intravenously with 10(6) microfilariae. ferrets (mustela putorius furo) inoculated with third-stage larvae typically became patent during the third month after infection, with a mean patency of 123 +/- 25 (se) days. ferrets injected intravenously with microfilariae exhibited a relatively constant microfilaremia for 3-4 weeks and usually c ...	1985	4029349
patterns of muscarinic cholinergic binding in the striatum and their relation to dopamine islands and striosomes.	the distribution of muscarinic cholinergic binding sites in the striatum was studied in relation to the locations of other neurochemical markers in the developing rat, cat, ferret, and human. in addition, patterns of striatal muscarinic binding were studied in the adult cat. receptor binding autoradiography was carried out with tritiated propylbenzilylcholine mustard [( 3h]-prbcm), an irreversible muscarinic antagonist, and subsequent serial section analyses involved comparisons among patterns o ...	1985	4031121
the relationship between intracellular calcium and contraction in calcium-overloaded ferret papillary muscles.	the photoprotein aequorin was microinjected into cells on the surface of ferret papillary muscles. tension and aequorin light, a function of intracellular ca concentration ([ca2+]i), were monitored. the preparations were exposed to increased concentrations of extracellular ca ([ca2+]o). small increases in [ca2+]o led to the usual increase in both the systolic light signal and the developed tension. however, high [ca2+]o led to a fall in developed tension known as ca overload. this fall of tensio ...	1985	4032294
nervous control of mucin secretion into human bronchi.	pieces of ferret trachea and human bronchi were mounted in ussing chambers and given [35s]sulphate as a radiolabelled precursor of mucous glycoproteins (mucins). the output of 35s bound to macromolecules was studied as an index of mucin secretion. in the ferret trachea, electrical field stimulation increased the rate of mucin secretion. tetrodotoxin (10(-7) m or 10(-6) m) abolished this effect. pilocarpine (25 microm) stimulated the output of mucins from human bronchus. atropine (10(-5) m) aboli ...	1985	4032317
measurement and stoichiometry of bumetanide-sensitive (2na:1k:3cl) cotransport in ferret red cells.	the bumetanide-sensitive uptake of na+, k+(rb+) and cl- has been measured at 21 degrees c in ferret red cells treated with (sits + dids) to minimize anion flux via capnophorin (band 3). during the time course of the influx experiments tracer uptake was a first-order rate process. at normal levels of external na+ (150 mm) the bumetanide-sensitive uptake of k+ was dependent on cl- and represented almost all of the k+ uptake, the residual flux demonstrating linear concentration dependence. the upta ...	1985	4032458
identification by specific radioimmunoassay of two novel peptides derived from the c-terminus of porcine preprogastrin.	a radioimmunoassay has been developed using antibodies to a synthetic analogue of the c-terminal hexapeptide sequence of the porcine gastrin precursor. boiling water extracts of porcine antral mucosa contained immunoreactive material that diluted in parallel with standard peptide. concentrations of immunoreactivity were 5.5 +/- 0.8 nmol x g-1 (mean +/- s.e.m.) in antral mucosa and were closely similar to those of c-terminal heptadecapeptide gastrin immunoreactivity (5.0 +/- 0.6 nmol x g-1). appr ...	1985	4035006
migration and differentiation of cerebral cortical neurons after transplantation into the brains of ferrets.	cells from the cerebral proliferative zones of newborn ferrets were labeled with tritiated thymidine and a fluorescent dye and were transplanted as a single-cell suspension into the occipital region of newborn ferrets. the transplanted cells became thoroughly integrated into the host environment: many cells migrated through the intermediate zone and into the cortical plate, where they developed as pyramidal neurons. other transplanted cells came to resemble glial cells. after 1 to 2 months most ...	1985	4035355
oestrus control in the ferret.		1985	4039501
coital stimuli controlling luteinizing hormone secretion and ovulation in the female ferret.	a series of experiments focused on the masculine coital behaviors controlling pituitary luteinizing hormone (lh) secretion and reflex ovulation in the estrous female ferret. an initial experiment investigated which coital stimuli from the male are required to induce ovulation. it was found that corpus luteum formation, which served as an index of ovulation, occurred in estrous female ferrets only if the male achieved a penile intromission. neck gripping, mounting, and pelvic thrusting behavior w ...	1985	4039954
effects of neonatal castration and testosterone treatment on sexual partner preference in the ferret.	groups of male and female ferrets were tested in a t maze to determine whether they preferred to approach and interact with a sexually active male or an estrous female. control male and female ferrets gonadectomized (gx) on postnatal day 35 and tested in adulthood while receiving no hormone or testosterone (t) displayed no significant preference. when given estradiol benzoate (eb), however, control males preferred stimulus females whereas control females preferred stimulus males. when tested in ...	1985	4040251
congenital malformations and variations in reproductive performance in the ferret: effects of maternal age, color and parity.	demographic data of ferrets from a commercial breeding colony were analyzed for the effects of maternal age, parity and strain on reproductive performance and the frequency of gross congenital abnormalities observed at parturition. litter size (mean +/- sem) was found to be greatest for young, primiparous females (10.3 +/- 0.2) and decreased with advancing maternal age and parity to a cohort mean of 8.1 +/- 0.1 for third parity females 16 months of age. age, parity or strain had no effect on 24- ...	1985	4040588
bone marrow hypoplasia associated with estrus in ferrets.	bone marrow hypoplasia was characterized in a group of female ferrets during prolonged estrus. all ferrets exhibited hematological changes characteristic of various degrees of bone marrow hypoplasia. hematological findings included initial thrombocytosis and leukocytosis followed by thrombocytopenia, leukopenia and anemia. platelet counts below 50,000/microliters were observed in 55% of the ferrets. hemorrhagic anemia due to thrombocytopenia was the most common cause of death and the mortality r ...	1985	4040589
wheel-running during anoestrus and oestrus in the ferret.	wheel-running activity was studied in female ferrets (mustela putorius furo), during periods of anoestrus and oestrus, as well as after gonadectomy. during anoestrus wheel-running was restricted to the hours of illumination, but during oestrus extended into the dark period and was increased overall, with the number of wheel revolutions being doubled or trebled. in spayed females wheel-running was mostly limited to the light periods.	1985	4041057
maturation of ovarian function in female ferrets is influenced by photoperiod.	sexual maturation of immature ferrets in response to a stimulatory photoperiod generally occurs within 6-7 weeks after imposition of long days at 16 weeks of age. in this study, females were examined for evidence of ovarian maturation after 22 days of exposure to the stimulatory photoperiod, before any sign of sexual maturation. the photoperiod-stimulated and control females were the same age (19 weeks), had similar body weights, and showed no evidence of vulvar oedema. comparison of oestradiol ...	1985	4045818
spontaneous plasma cell myeloma in a ferret (mustela putorius furo).		1985	4049681
interaction between ventricular cells during the early part of excitation in the ferret heart.	the source-load interaction during impulse propagation of excited and unexcited cells respectively was studied in the working myocardium. velocity of propagation and the shape of the early part of the action potential was measured in ferret papillary muscles or trabeculae with the preparation surrounded by either a large volume or a thin layer of tyrode solution, the latter situation being established by means of a silicone fluid bath technique. quick changes between the two situations resulted ...	1985	4050489
comparisons of tracheostomy incisions in a pediatric model.	tracheostomy in children causes approximately twice the mortality and morbidity as in the adult. the occurrence of complications correlates closely with the severity of the preoperative tracheal disease, the length of time the tracheostomy is needed, and the age of the patient. morbidity documented in the postoperative period includes tracheal stenosis and collapsible anterior tracheal wall. the increased incidence of these problems in the pediatric patient may be related to the less rigid natur ...	2017	4051401
influence of day length and endocrine status on luteinizing hormone secretion in intact and ovariectomized adult ferrets.	the purpose of this study was to examine the pituitary-ovarian relationship of both estrous and anestrous female ferrets. the endocrine status of the animals was induced by manipulating photoperiod: females in estrus were housed in long days (16l:8d); females in anestrus were housed in short days (8l:16d). for studies of intact animals in both photoperiods, plasma luteinizing hormone (lh) levels were quantified in blood samples collected from adult ferrets at 5-min intervals over a 24-h period. ...	1985	4052529
role of extrinsic and intrinsic nerves in the relationship between intestinal motility and transmural potential difference in the anesthetized ferret.	in the anesthetized ferret jejunum, the role of extrinsic and intrinsic nerves in the relationship between intestinal motor activity and transmural potential difference (pd) was studied. in the vagally intact ferret and after sympathetic blockade, spontaneous bursts of jejunal motor activity were associated with fluctuations in transmural pd. both responses were abolished by vagotomy, atropine, and tetrodotoxin. prolonged electrical stimulation of the cervical vagus nerve induced a cyclical moti ...	1985	4054520
recurrent adenocarcinoma in a ferret.	a 4.5-year-old, neutered male ferret with a history of recurrent adenocarcinoma in the preputial region was given 2 radiation treatment courses designed to control the rapidly growing neoplasm. the tumor regressed completely after the first 3.5-week course of therapy. the ferret remained clinically disease-free for 4 months, at which time small masses were noticed in the inguinal area and the original tumor site. a second course of therapy was administered, which again resulted in complete clini ...	1985	4055507
attenuation of wild-type human influenza a virus by acquisition of the pa polymerase and matrix protein genes of influenza a/ann arbor/6/60 cold-adapted donor virus.	wild-type influenza a viruses can be attenuated for humans by the acquisition of genes from the a/ann arbor/6/60 cold-adapted (ca) donor virus. six-gene reassortants, that is, viruses containing the hemagglutinin and neuraminidase surface glycoprotein genes of the wild-type virus and the six remaining rna segments of the ca donor virus, are consistently attenuated for humans. during the production of a six-gene reassortant virus containing the surface glycoproteins of the a/washington/897/80 (h3 ...	1985	4056002
morphology, central projections, and dendritic field orientation of retinal ganglion cells in the ferret.	retinal ganglion cells were studied in pigmented ferrets that received small electrophoretic injections of horseradish peroxidase (hrp) into the dorsal lateral geniculate nucleus (lgnd) or optic tract. ferret retina contains a number of types of retinal ganglion cells of which the relative cell body sizes, dendritic field structures, and central projections correspond closely to those of retinal ganglion cell types in the cat. ferret retina contains about the same proportion of alphalike cells, ...	1985	4056111
gastric tone modifies the responses to extrinsic neural stimuli in the anaesthetized ferret.	to determine the relation between resting intragastric pressure and neuronally evoked motility responses, the stomach of the anaesthetized ferret was inflated with two volumes within the physiological range. vagal evoked contractions decreased as the resting pressure was increased. the decrease affected responses to high, but not low, intensity stimulation of the vagus. vagal evoked relaxation of the stomach increased as a linear function of resting pressure. atropine lowered the resting pressur ...	1985	4057085
oestrus-associated anaemia in the ferret.		1985	4060555
effects of ryanodine on intracellular ca2+ transients in mammalian cardiac muscle.	we observed the effects of ryanodine on the aequorin luminescence, membrane potential, and contraction of canine cardiac purkinje fibers and ferret ventricular muscle. in canine purkinje fibers, ryanodine (10 nm to 1 microm) abolished the spontaneous spatiotemporal fluctuations in [ca2+] that occur as a result of ca2+-induced ca2+ release from the sarcoplasmic reticulum (sr) during exposure to low-na+ solutions. ryanodine strongly reduced the twitch and both components of the intracellular aequo ...	1985	4065357
brainstem connections of vagal afferent nerves in the ferret: an autoradiographic study.	using an autoradiographic technique the central connections of vagal afferent fibres in the ferret were studied. the results show that the principal site of termination is the ipsilateral nucleus of the tractus solitarius with smaller projections to the contralateral tractus nucleus, the dorsal motor nucleus of the vagus and the area postrema and subpostrema. the fibres cross the midline via the commissural nucleus of cajal. no evidence of vagal afferent fibres was found in the reticular formati ...	1985	4066482
the projection of the visual field onto the lateral geniculate nucleus of the ferret.	the projection of the visual field onto the dorsal lateral geniculate nucleus (lgn) of the ferret was mapped electrophysiologically. the nucleus contains a single orderly map of the contralateral visual hemifield. the upper visual field is represented dorsally and rostrally in the nucleus; central fields are found in the medial and caudal sections of the lgn; and peripheral fields are represented most laterally. the ipsilateral eye is represented in laminae a1 and c1 up to eccentricities of 20-3 ...	1985	4067015
anatomical organization of primary visual cortex (area 17) in the ferret.	the present report describes the intrinsic and extrinsic cortical connectivity of striate cortex (area 17) in the ferret. injections of horseradish peroxidase demonstrate periodic intrinsic connections over an extent of 2.5-3.0 mm, mainly in the supragranular layers but also occurring secondarily in layer 5. these connections have a stripelike configuration, with a center-to-center spacing of 0.5-0.7 mm. their laminar distribution and stripelike configuration resemble the pattern in the cat (gil ...	1985	4067016
distribution of ganglion cells in the retina of adult pigmented ferret.	the retinal ganglion cell distribution in adult pigmented ferret was mapped in nissl-stained retinas and in retinas back-filled with hrp after large bilateral injections of the enzyme into the brain. in common with other carnivores the ferret has an area of peak cell density equivalent to the area centralis and a prominent visual streak of high cell density extending horizontally across the retina. the maximum ganglion cell densities for the retinas were estimated to be 3500-5200 cells/mm2 in ni ...	1985	4075115
effect of exposure to 500 ppm sulfur dioxide on the lungs of the ferret.	male ferrets (mustela putorius furo) were exposed 3 h/day, 3 days/week for 12 weeks to 500 ppm so2. determinations were made of airway responsiveness by producing histamine dose-effect curves. lung tissues were fixed and studied by light and electron microscopy. epithelial cells of the trachea and bronchus were most affected. lesions observed included changes in ciliated cells, edema and cell infiltration. the most responsive animals to histamine were 2 from the exposed group. nasal discharge an ...	1985	4081352
vagal control of fluid transport, transmural potential difference, and motility in the ferret jejunum.	the role of the vagus nerve in the control of intestinal transport was investigated in the ferret jejunum in vivo. fluid transport was measured in an isolated 10-cm segment of jejunum by means of a single-pass perfusion technique with radioactive markers introduced into the perfusion fluid and the bloodstream of the animal. transmural potential difference (pd) and intraluminal pressure in the perfused jejunal loop were also monitored. vagal stimulation (20 hz, 20 v, and 0.5 ms for 1 min) resulte ...	1985	4083347
osteoma in a ferret.		1985	4086359
olfactory deprivation enhances normal spine loss in the olfactory bulb of developing ferrets.	ferrets show a sensitive phase in their postnatal development during which they can become imprinted to food odors. at the same time the number of granule cell spines in the olfactory bulb reaches a maximum, declining significantly thereafter. in ferrets, exposed continuously to saturated levels of geraniol odor in the cage environment, the normal decline in spine number (occurring between day 60 and 90) is significantly enhanced. no such effects were observed during earlier ontogenetic phases. ...	1985	4088530
calcium-force relationships as detected with aequorin in two different vascular smooth muscles of the ferret.	the bioluminescent calcium indicator aequorin was chemically loaded into isolated strips of ferret portal vein and ferret aorta. aequorin light emission (a function of [ca2+]i) was recorded simultaneously with tension. assuming an [mg2+]i of 0.5 mm, [ca2+]i was 1.8 x 10(-7) m in the unstimulated portal vein at 22 degrees c where there was negligible resting tone. in contrast, in the unstimulated aorta at 22 degrees c where there was significant basal tone, the [ca2+]i was 2.7 x 10(-7) m. in both ...	1985	4093883
morphology, organelles and susceptibility to viruses of cultured ferret cells.	cells explanted from a normal 6-week-old ferret's brain have been subcultured over 100 times, have undergone over 400 population doublings, possess ferret-specific antigens and are referred to as mpf cells. low passage-level mpf cells formed diffuse colonies with ill-defined borders which had a swirling 'finger-print' pattern whereas the colonies formed by high passage-level cells were more densely populated and had distinct borders. mpf cells at their 100th passage level appeared as a loose mon ...	1985	4094568
[immunovirologic markers of the risk of influenza a h3n2 among swine].	a seroepidemiological survey using the radial haemolysis test has been performed on a representative sampling of the pig herds in brittany. since 1978, influenza a h3n2 strains spread in that reservoir giving subclinical infections. we detected antibodies directed against the influenza prototypes isolated during the human outbreaks from 1973 to 1977. only one h3n2 virus was isolated in 1980: its antigenic structure was in agreement with the previous serological data. in 1984 outbreaks of swine i ...	1985	4095329
the nasal decongestant action of aspirin in influenza infected ferrets.		1973	4121164
immunohistological, microscopical and neurochemical studies on encephalitides. vi. subacute sclerosing panencephalitis. histopathological and histochemical analysis of experimental encephalitis induced in ferrets by sspe viruses.		1973	4121657
canine distemper virus in ferret, dog and bovine kidney cell cultures.		1965	4160642
monoclonal gamma-globulins in ferrets with lymphoproliferative lesions.		1966	4162607
hypergammaglobulinemia in ferrets with lymphoproliferative lesions (aleutian disease).		1967	4169207
experimental cerebrovascular lesions in congenital and neonatal rubella-virus infections of ferrets.		1968	4173270
the blood supply of the pituitary gland of the ferret with special reference to infarction after stalk section.		1969	4179632
transmissible mink encephalopathy in carnivores: clinical, light and electron microscopic studies in raccons, skunks and ferrets.		1973	4197711
comparative distemper vaccine titrations in ferrets and minks.		1973	4208099
immunity to influenza in ferrets. ix. delayed hypersensitivity following infection or immunization with a2/hong kong virus.		1974	4218297
reproduction in the ferret (mustela furo). i. uterine histology and histochemistry during pregnancy and pseudopregnancy.		1966	4223795
gastric hypochlorhydria in ferret distemper.	in the present investigation 42 female ferrets were studied in regard to the influence of canine distemper in this species on gastric acid secretion. a total of fifteen naturally-infected and 27 non-infected ferrets were fasted and pylorus-ligated, and were either injected with corticosterone (10 or 50 mg/kg, s.c. one injection/day for 4 days) suspended in corn oil, injected with corn oil, on non-injected. prior to autopsy blood samples were acquired for corticosterone analysis, and at autopsy t ...	1967	4226681
studies on southeast asian haemaphysalis ticks (ixodoidea, ixodidae). redescription of type material of h. (rhipistoma) heinrichi schulze, a parasite of the ferret-badger in burma and vietnam.		1968	4248491
response of ferrets and monkeys to intranasal infection with human, equine and avian influenza viruses.	rhesus monkeys and ferrets were exposed to intranasal inoculation of several strains of egg-adapted avian, equine and human influenza viruses and to strains of mouse-adapted equine influenza viruses. local replication of virus and seroconversion were observed in the majority of these animals. however, clinical infection was observed only in ferrets.	1971	4251419
dermatomycoses in fur animals: chinchilla, ferret, mink and rabbit.		1972	4257259
light and electron microscope observations at the pre- and early post-implantation stages in the ferret uterus.		1973	4271172
the development of a maternal pregnancy reaction in the ferret.		1974	4278308
effect of caffeic acid on mouse and ferret lung infected with influenza a virus.		1965	4286922
the control of corpus luteum function in the ferret.		1967	4302528
hydrocephalus in hamsters, ferrets, rats, and mice following inoculations with reovirus type i. i. virologic studies.		1969	4309400
hydrocephalus in hamsters, ferrets, rats, and mice following inoculations with reovirus type i. ii. pathologic studies.		1969	4309401
quantitative studies of pseudorabies virus in mink, ferrets, rabbits and mice.		1971	4327892
the ferret (mustela putorius furo l.) as a laboratory animal.		1971	4329234
immunity to influenza in ferrets. ii. influence of adjuvants on immunization.		1972	4338059
the effect of parinfluenza virus type 3 on newborn ferrets.		1974	4376553
[subacute sclerosing panencephalitis van bogaert's subacute sclerosing leucoencephalitis. outline of past findings and future prospects].	after a short historical introduction, the author presents the actual state of our biological knowledge with special reference to the increase of gamma-globulines and measle anti-bodies in the serum as well as in the csf. he insists upon the works which identified and isolated the measle anti-gene but which nevertheless cannot define a special form of measle encephalities. two hypothesis (a) immunologic (b) viral, could give an explanation of the observed facts. the neuro-pathological modificati ...	1971	4377852
chlorcyclizine produced cleft palate in the ferret.		1968	4387946
gastric lesions produced by cinchophen in the ferret.		1971	4395866
immunity to influenza in ferrets. xii. immunization of ferrets with tnbp-split influenza virus vaccine.		1974	4413778
pyometra in a domestic ferret.		1974	4420379
immunity to influenza in ferrets. 13. protection against influenza infection by serum antibody to homologous haemagglutinin or neuraminidase antigens.		2012	4422499
immunization of ferrets against influenza: a comparison of killed ferret grown and egg grown virus.		1974	4422501
proceedings: the determination of a 'critical period' for the induction of the maternal pregnancy reaction in the ferret.		1974	4448729
proceedings: an experimental study of the accessory optic system in the ferret.		1974	4448751
proceedings: the role of the pineal gland in the response of ferrets to artificially restricted photoperiods.		1974	4475087
a new vaccine strain of feline panleukopenia virus grown in ferret cell culture.		1974	4491924
lack of relationship between the degree of induced gingival hyperplasia and the concentration of diphenylhydantoin in various tissues of ferrets.		2017	4501305
distribution and metabolism of diphenylhydantoin in oral and nonoral tissues of ferrets.		2017	4511308
immunity to influenza in ferrets. v. immunization with inactivated virus in adjuvant 65.	ferrets infected with influenza virus a2/hong kong/3/68 responded with a febrile reaction; the temperature was elevated by 1.0 degrees c. or greater to a level of 40 degrees c. or more. in addition, relatively high titres of virus were recovered from nasal washings taken 3 days after virus infection, serum antibody was produced, increased nasal protein was detected and nasal washings contained both hi and neutralizing antibody. of four ferrets immunized with 400 cca units of inactivated influenz ...	1973	4511952