Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| uveoscleral outflow: diffusion or flow? | shallow peripheral ciliochoroidal detachments with 10(-4) m fluorescein isothiocyanate dextran 70 were created in cynomolgus monkey eyes. anterior chamber fluorophotometric readings were taken for 6 hr. from the anterior chamber fluorescence values, the rate of tracer movement from the supraciliary space into the anterior chamber was calculated. the rate of movement was 0.003 microliter/min, expressed in equivalent volumes of tracer solution. this value is more than 200 times lower than the rate ... | 1987 | 2438249 |
| fluctuations of t- and b-cell subsets in basic protein-induced experimental allergic encephalomyelitis (eae) in long-tailed macaques. | experimental allergic encephalomyelitis (eae) was induced in long-tailed macaques (macaca fascicularis) by inoculation of autologous myelin basic protein (bp) in complete freund's adjuvant. natural killer (nk) cell activity and lymphocyte subsets detected by one- and two-color immunofluorescence were monitored longitudinally in these animals. a decrease in nk cell activity was detected at the onset of clinically defined disease. during the preclinical phase of eae (5-7 days before the onset of c ... | 1987 | 2439243 |
| non-invasive assessment of the pyramidal tract and motor pathway of primates. | non-invasive direct stimulation of the motor cortex of cynomolgus monkeys has been used to assess in awake and anesthetized animals the central and peripheral conduction times of the motor pathway and to measure the latencies of the descending spinal volley of the pyramidal tracts. repetitive stimulation failed to induce convulsive activity or detectable pathological changes. peripheral latencies were comparable with those obtained from f-wave analysis. central conduction times for corticospinal ... | 1987 | 2439282 |
| pharmacokinetics and metabolism of bisoprolol-14c in three animal species and in humans. | the pharmacokinetic properties of bisoprolol-14c were studied in wistar rats, beagle dogs, and cynomolgus monkeys. bisoprolol is well absorbed in these species; independent of the route of administration (i.v. or p.o.), 70-90% of the 14c-dose was recovered in urine. faecal excretion was approximately 20% in rats and less than 10% in dogs and monkeys. rats excreted approximately 10% of the dose in bile after i.v. as well as after oral administration. the plasma half-life of the unchanged drug was ... | 1986 | 2439794 |
| serological survey and virus isolation of simian t-cell leukemia/t-lymphotropic virus type i (stlv-i) in non-human primates in their native countries. | infection with a simian retrovirus (stlv-i) closely related to human t-lymphotropic virus type i (htlv-i) was investigated in non-human primates living in their native countries in africa and asia. serum antibodies cross-reacting with htlv-i antigens were detected in 85 of 567 non-human primates of 30 species. seropositive animals were found among african green monkeys, olive baboons, sykes' monkeys, mandrills and patas monkeys in several countries in africa, and cynomolgus monkeys, celebes maca ... | 1987 | 2440820 |
| nondependent monkeys self-administer hydromorphone. | four monkeys, 2 rhesus and 2 cynomolgus, were trained to perform a multiple fixed-ratio extinction (mult/fr/ext) schedule for banana pellets. subsequently, all animals were given hydromorphone (hym) self-administration training, which consisted of substitution of fr (fixed ratio) 2 cocaine for fr 80 banana pellets and substitution of fr 2 hym for fr 2 cocaine. all of the animals acquired cocaine self-administration. they also acquired hym self-administration when it was substituted for cocaine. ... | 1985 | 2441722 |
| regulatory peptides in the respiratory tract of macaca fascicularis. | the quantitative distribution and localisation of seven regulatory peptides (vasoactive intestinal peptide (vip), peptide histidine methionine (phm), calcitonin gene related peptide (cgrp), galanin, substance p, neuropeptide tyrosine (y), and bombesin like peptides) were determined by radioimmunoassay and immunocytochemistry in six different regions of the respiratory tract of the cynomolgus monkey, macaca fascicularis. in general, peptide concentrations were higher in the airways than in lung t ... | 1987 | 2443994 |
| primate involucrins: antigenic relatedness and detection of multiple forms. | hominoid apes (gorilla, chimpanzee, orangutan, gibbon), old world monkeys (rhesus, cynomolgus), new world monkeys (owl, cebus), and a prosimian (lemur) express involucrin-like proteins in cultured keratinocytes. primate involucrins can be precipitated with trichloroacetic acid, resolubilized at ph 8, and subsequently retain aqueous solubility in 67% ethanol. polyacrylamide gel electrophoresis of keratinocyte extracts after this rapid partial purification has revealed in each species tested one ( ... | 1987 | 2444982 |
| in vivo administration of anti-cd4 monoclonal antibody prolongs survival in longtailed macaques with experimental allergic encephalomyelitis. | the in vivo administration of monoclonal antibody (mab) to the cd4 antigen associated with helper t cells has been successful in prolonging the survival of nonhuman primates with experimental allergic encephalomyelitis (eae). eae was induced in 17 outbred longtailed macaques (macaca fascicularis) by inoculation of homologous myelin basic protein (bp) in complete freund's adjuvant (cfa). treatment was begun at the onset of clinical signs. eleven animals were treated with anti-cd4 mab leu3a (eight ... | 1987 | 2445510 |
| the entorhinal cortex of the monkey: ii. cortical afferents. | the entorhinal cortex of the monkey is commonly viewed as the major link between the cerebral cortex and the other fields of the hippocampal formation. until recently, however, little was known about the origins of the cortical projections to the entorhinal cortex, and most of the available information is still based on degeneration studies. we have carried out a systematic analysis of these connections by placing small injections of the retrograde tracer wheat germ agglutinin conjugated to hors ... | 1987 | 2445796 |
| effect of butyl 3-(1h-tetrazol-5-yl) oxanilate (mtb) on immunological or non-immunological histamine and srs(-a) release from guinea-pig, monkey and human lung tissue. | we investigated the influence of butyl 3-(1h-tetrazol-5-yl) oxanilate (mtb) on the release of histamine and slow reacting substance of anaphylaxis (srs-a) in vitro. mtb dose-dependently inhibited the release of not only histamine but also srs-a from passively sensitized guinea-pig lung, while disodium cromoglycate (dscg) hardly affected either release. mtb also resulted in a dose-dependent inhibition of the release of these mediators from the passively sensitized cynomolgus and rhesus monkey and ... | 1987 | 2446036 |
| anterior segment ischemia after recession of various recti. an experimental study. | in 40 normal adult cynomolgus monkey eyes, recession of various recti in different combinations was done to evaluate their effects on the anterior segment. these procedures were done as primary, secondary, tertiary, and fourth procedures (each separated by several weeks or months), ultimately involving all four recti in the eyes. in 11 eyes, posterior ciliary arteries (pcas) were occluded to determine its effects on the anterior segment. all eyes were examined by slit lamp, color photography, an ... | 1987 | 2446229 |
| induction of estrogen-related hyperplastic changes in the prostate of the cynomolgus monkey (macaca fascicularis) by androstenedione and its antagonization by the aromatase inhibitor 1-methyl-androsta-1,4-diene-3,17-dione. | the cynomolgus monkey was selected as an experimental model to investigate the role of estrogens in the pathogenesis of benign prostatic hyperplasia (bph) because its prostate seems to be more like the human prostate than that of other primate species. the treatment of intact, adult animals with the aromatizable substrate androstenedione for 3 months resulted in no significant changes in prostate weight, but in microscopically clearly detectable estrogen-related hyperplastic changes, particularl ... | 1987 | 2446299 |
| distributions of certain neuropeptides in the primate thalamus. | the distributions of fibers and terminals immunoreactive for somatostatin (srif), neuropeptide y (npy), substance p (sp) and cholecystokinin octapeptide (cck), were studied in the diencephalon of cynomolgus monkeys. immunoreactivity for all 4 peptides is found in extrinsic afferent fibers innervating the dorsal thalamus, ventral thalamus and epithalamus. the distributions of such fibers are more extensive than previously described and include many relay nuclei in their zones of terminations. sp ... | 1987 | 2446708 |
| mucosal t cells provide helper function but do not proliferate when stimulated by specific antigen in lymphogranuloma venereum proctitis in nonhuman primates. | to study antigen-specific immune responses of gut-associated t lymphocytes after gastrointestinal infection, cynomolgus monkeys were inoculated rectally with chlamydia trachomatis of the l2 [lymphogranuloma venereum (lgv)] strain. infected monkeys developed a chronic proctitis with the appearance of lgv-specific immunoglobulin g-antibodies in the serum. lymphocytes isolated from the peripheral blood, the spleen, and draining lymph nodes had a vigorous antigen-specific proliferative response to l ... | 1988 | 2446947 |
| uveoscleral outflow using different-sized fluorescent tracers in normal and inflamed eyes. | sodium fluorescein and fluorescinated dextrans (fd) of selected molecular weights were combined and perfused into the anterior chamber of normal and inflamed eyes of cynomolgus monkeys. the eyes were dissected into iris, anterior and posterior uvea, anterior and posterior sclera, retina and intraocular fluids (excluding aqueous). each tissue was homogenized and centrifuged and the supernatant was run through a gel-filtration column to separate the fluorescent tracers. each of the resultant peaks ... | 1987 | 2448157 |
| disparate visceral neuronal pools subserve spinal cord and ciliary ganglion in the monkey: a double labeling approach. | the fluorescent dyes nuclear yellow, a nuclear marker, and fast blue, a cytoplasmic marker, were utilized in a double-labeling procedure. one or the other of these dyes was injected sequentially into the cervical spinal cords and ciliary ganglia of 6 cynomolgus monkeys. no double labeling of cells was noted in the anterior median nucleus, edinger-westphal nucleus, or nucleus of perlia in the mid-brain. | 1988 | 2451977 |
| immunosuppression of canine, monkey, and baboon allografts by fk 506: with special reference to synergism with other drugs and to tolerance induction. | in dogs the most effective oral dose of fk 506 for prevention of renal homograft rejection was 1.5 mg/kg/day. with maximum credit allowed at 90 days, survival was increased to 61.0 +/- 33.6 (sd) days compared with 13.0 +/- 4.1 in untreated control animals. higher doses were toxic. the smallest dose that was used (0.5 mg/kg/day) prolonged survival after renal transplantation to 33.7 +/- 23.9 (sd) days. when the small dose of fk 506 was combined with 5 mg/kg/day of cyclosporine and 5 mg of prednis ... | 1988 | 2456627 |
| immunohistochemical study of tissue polypeptide antigen (tpa) and cancer antigen 125 (ca125) in the human and cynomolgus monkey placenta, umbilical cord and decidua. | tissue polypeptide antigen (tpa) and cancer antigen 125 (ca125) were studied immunohistochemically by the avidin-biotin immunoperoxidase technique in human and cynomolgus monkey placentae, membranes, umbilical cords and decidua. in early human placentae, tpa was localized mainly in the cell membranes of villous syncytio- and cyto-trophoblast. the cytoplasm of those trophoblastic cells were weakly stained with tpa. the membrane of basal chorionic trophoblast cells was strongly stained with tpa an ... | 1988 | 2458702 |
| killer cell systems of cynomolgus monkeys experimentally infected with htlv-1. | the cell-mediated killer activity in cynomolgus monkeys, which were infected 2.5 yr previously with htlv-1, was examined. with htlv-1-infected autologous lymphoid cells as targets, htlv-1-specific killer cells were not detected among pbl cells of infected monkeys, but in monkeys in which specific memory cells were found. these memory cells were converted to active specific killer cells by stimulation with mytomycin c (mmc)-treated htlv-1 infected autologous cells in vitro. target blocking by ant ... | 1988 | 2459198 |
| the development of vitreous membranes and retinal detachment induced by intravitreal carbon microparticles. | we induced intravitreal cellular proliferation by injection of carbon microparticles (size 20-70 nm) into the vitreous of 21 eyes of 11 cynomolgus monkeys. pathological changes were evaluated by light and electron microscopy. at 1 week, there was conspicuous cyclitis showing exudative separation of the nonpigmented and pigmented ciliary epithelium, inflammatory cells, mononuclear phagocytes, and premacular vitreous detachment. at 3 weeks, continued macrophagic response was accompanied by fibrova ... | 1988 | 2461330 |
| [granulocyte colony-stimulating factor (g-csf): biochemistry, biology and pathophysiology]. | g-csf belongs to a family of hematopoietic growth factors, also known as colony stimulating factors. it supports the growth and differentiation of predominantly committed neutrophil precursors and activates the function of peripheral blood neutrophils in vitro. in vivo studies in primates (cynomolgus monkeys) demonstrated that g-csf is a potent myeloid growth and differentiation factor causing a dose-dependent increase predominantly in the peripheral blood neutrophils. to assess the effects of g ... | 1988 | 2463402 |
| the periurethral zone of the prostate of the cynomolgus monkey is the most sensitive prostate part for an estrogenic stimulus. | in man, benign prostatic hyperplasia (bph) develops in the so-called transition zone of the periurethral region of the prostate. assuming that estrogens have a specific effect in this context, it would be expected that the periurethral glands are the most sensitive prostate part for an estrogenic stimulus. morphological and immunocytochemical studies of serial sections of the prostate of castrated male adult cynomolgus monkeys treated with 17 beta-estradiol for a period of three months revealed ... | 1988 | 2464165 |
| tissue-specific expression of the prostatic secretory protein psp94 in cynomolgus monkey (macaca fascicularis. | 1988 | 2464431 | |
| anatomic connections of inferior parietal cortex (area 7) with subcortical structures related to vestibulo-ocular function in a monkey (macaca fascicularis). | connections of the posterior parietal cortex (area 7) with subcortical structures related to the vestibulo-ocular function were studied on four macaque monkeys by using anterograde and retrograde tracer. wheat germ agglutinin (wga)-horseradish peroxidase (hrp) or tritiated amino acids were injected into the posterior part of area 7, including the caudal end of the superior bank of both the superior temporal sulcus and the lateral sulcus. the posterior parietal cortex was found to be reciprocally ... | 1989 | 2465325 |
| projections of the temporo-parietal cortex on vestibular complex in the macaque monkey (macaca fascicularis). | connections of the posterior parietal cortex (area 7) with the vestibular complex have been studied in 4 macaque monkeys by anterograde axonal transport methods. wga-hrp and tritiated amino-acids have been injected in the posterior part of area 7 including the caudal end of the superior bank of superior temporal sulcus and the lateral sulcus. labeled terminals were observed in the vestibular nuclei complex and distributed bilaterally with a greater ipsilateral contribution. two main groups of ar ... | 1988 | 2466684 |
| recombinant human granulocyte-colony stimulating factor: in vivo effects on myelopoiesis in primates. | g-csf belongs to a family of hematopoietic growth factors, also known as colony stimulating factors. it supports the growth and differentiation of predominantly committed neutrophil precursors and activates the function of peripheral blood neutrophils in vitro. in vivo studies in primates (cynomolgus monkeys) demonstrated that g-csf is a potent myeloid growth and differentiation factor causing a dose-dependent increase predominantly in the peripheral blood neutrophils. to assess the effects of g ... | 1988 | 2467644 |
| in vivo effects of recombinant colony stimulating factors on hematopoiesis in cynomolgus monkeys. | 1989 | 2468246 | |
| cellular mechanisms of iris neovascularization secondary to retinal vein occlusion. | we developed an animal model that allows the early phases of iris neovascularization to be studied in detail. three major retinal branch veins were occluded with the argon laser in five eyes of cynomolgus monkeys, after which the eyes were enucleated at various time intervals. we observed three phases of the neovascular process in the iris. the early phase was characterized by vessel dilation and intense uptake of tritiated thymidine in the vascular endothelial cells. in the intermediate phase, ... | 1989 | 2468330 |
| influence of gonadal steroids on human and monkey cerebrospinal fluid homovanillic acid concentrations. | the influence of gonadal steroids on central dopaminergic function was assessed by measuring concentrations of the dopamine metabolite homovanillic acid (hva) in cerebrospinal fluid (csf) in humans and monkeys. csf hva and 5-hydroxyindoleacetic acid (5-hiaa) concentrations were measured by high performance liquid chromatography with electrochemical detection. thirteen intact adult female monkeys (macaca fascicularis) and six ovariectomized monkeys had a lumbar puncture to collect csf. ovariectom ... | 1989 | 2469538 |
| ultrastructural and paraphenylene studies of degeneration in the primate visual system: degenerative remnants persist for much longer than expected. | it is a widely held belief that the products of axonal degeneration in the cns are transitory and are caused by metabolic and phagocytic processes. however, recent light microscopic examinations of human and primate brains using the paraphenylene diamine staining method (ppd), which stains degenerating axons, have confirmed that the products of degeneration persist for years in visual pathways. the routine utilization of the ppd method for delineating human visual pathways requires further confi ... | 1988 | 2469780 |
| chronological relationships between mediator release and changes in airway dynamics during an ascaris response in sensitive cynomolgus monkeys. | recently identified ascaris suum sensitive cynomolgus monkeys were further characterized to determine if a chronologic relationship existed between mediator release and onset of bronchoconstriction. in these anesthetized ascaris-sensitive monkeys, aerosol antigen challenge of each animal produced rapid and severe bronchoconstriction, as determined by decreases in dynamic lung compliance (-80.2 +/- 4.1%) and airway conductance (-64.5 +/- 13.8%). maximum changes were achieved within 5 min followin ... | 1989 | 2470112 |
| enterically transmitted non-a, non-b hepatitis: identification of virus-associated antigen in experimentally infected cynomolgus macaques. | an antigen (hevag) associated with enterically transmitted non-a, non-b (et-nanb) hepatitis virus has been identified in hepatocytes of cynomolgus macaques (macaca fascicularis) infected with et-nanb hepatitis by using an immunofluorescent probe prepared from serum previously shown by immune electron microscopy to react with et-nanb viruslike particles. hevag was observed in the cytoplasm of hepatocytes in 27 of 29 infected macaques in five passages of the diseases but not in uninoculated macaqu ... | 1989 | 2470832 |
| serum lipids, lipoproteins, hemodynamics, and hemostasis in doxazosin-treated monkeys. | the effect of doxazosin administration on hemodynamics, hemostasis, and serum lipid and lipoprotein levels was investigated in cynomolgus monkeys (macaca fascicularis) with diet-induced hypercholesterolemia. acute administration of doxazosin (1 and 5 mg/kg) reduced resting mean arterial pressure by 20% without affecting heart rate, and completely inhibited the pressor response to phenylephrine. platelet aggregation, prothrombin time, and activated partial thromboplastin time were not altered by ... | 1989 | 2471012 |
| structure-kinetic relationships of choriogonadotropin and related molecules. | to assess how profound differences in carbohydrate and/or polypeptide structures affect parameters of plasma disappearance of glycoprotein hormones, we calculated and compared the initial volume of distribution, rate constants, and metabolic clearance rates of several highly purified human choriogonadotropin (hcg) analogues in monkeys. hcg, deglycosylated hcg, desialylated hcg, or core fragment of hcg-beta purified from pregnancy urine (beta-core) was administered as a rapid intravenous injectio ... | 1989 | 2472071 |
| sex-linked differences in susceptibility of cynomolgus monkeys to type ii collagen-induced arthritis. evidence that epitope-specific immune suppression is involved in the regulation of type ii collagen autoantibody formation. | to determine whether sex-linked factors are important in the susceptibility and resistance of cynomolgus monkeys to type ii collagen-induced arthritis, we immunized 5 males and 10 females with chick type ii collagen (cii) and studied their clinical and immune responses. all 10 females developed overt arthritis and produced antibodies to cii and cross-reactive antibodies to monkey type ii collagen (mkii). in contrast, only 1 male monkey developed arthritis, which was transient and mild in severit ... | 1989 | 2472147 |
| extended contact lens wear in the developing cynomolgus monkey eye. recovery from adverse responses. | soft extended wear contact lenses were designed for and fitted to 12 eyes of 11 infant semiwild cynomolgus monkeys. the lenses were satisfactorily worn over observation periods of up to 465 days, the longest continuous period of lens wear being 69 days. however, some of the corneas were subject to a pattern of complications analogous to that in human contact lens wear. nine eyes showed adverse responses, and of these, the ocular complications were severe enough in four cases to cause abandonment ... | 1989 | 2472928 |
| pregnancy-associated plasma protein-a in pregnant cynomolgus monkeys (macaca fascicularis): radioimmunoassay, normal levels, effect of ru 486, and preliminary characterization. | pregnancy-associated plasma protein-a (papp-a) is a human macromolecular glycoprotein produced by the trophoblast and possibly by the decidua. its biological function is unknown, but in vitro, papp-a has been reported to be an inhibitor of granulocyte elastase. the present study was undertaken to see if pregnant cynomolgus monkeys could be an animal model sufficiently close to the human situation to study the physiology of papp-a. an antiserum to pregnant cynomolgus plasma was raised in rabbits. ... | 1989 | 2473787 |
| polyclonal rabbit gamma globulins against a human cytotoxic cd4+ t cell clone. i. clone characteristics and antiblast globulin preparation. | antihuman lymphocyte rabbit (or horse) gamma globulins used in recipients of organ transplantation are prepared against thymocytes or immortalized cell lines, the only two sources so far allowing enough antigen preparation. these cells lack, however, the surface determinants characteristic of alloreactive blasts involved in the rejection process. we have derived long-term cultures of a panel of alloreactive (untransformed) clones from a rejected kidney. among them, clone 1e7 has been chosen as a ... | 1989 | 2474210 |
| light and electron microscopical studies of the substance p innervation of the dorsal column nuclei and the lateral cervical nucleus in the primate. | in 2 monkeys of the species macaca fascicularis the three dorsal column nuclei and the lateral cervical nucleus have been investigated immunocytochemically with antiserum against substance p. the substance p labeling was widely spread but rather sparse. it occurred in small structures of the size of boutons in the gracile, main cuneate and lateral cervical nucleus. the most intensive labeling of the gracile nucleus was found in the dorsal border of the nucleus and the lateral part of the caudal ... | 1989 | 2474880 |
| sex steroid-binding protein: identification and comparison of the primary product following cell-free translation of human and monkey (macaca fascicularis) liver rna. | a very close similarity in molecular, steroid-binding and immunological properties have been demonstrated for the sex steroid-binding proteins of plasma from human (hsbp) and monkey (msbp): both are glycoproteins composed of two similar subunits able to bind one steroid molecule and to cross-react with the same antibodies. after translation of human and monkey (macaca fascicularis) liver mrnas by a wheat-germ embryo extract, in the presence of labelled amino-acids, we have characterized in both ... | 1989 | 2475674 |
| antichlamydial specificity of conjunctival lymphocytes during experimental ocular infection. | antigen-specific responses to chlamydiae have been demonstrated with lymphocytes isolated from the conjunctiva after primary ocular infection and after topical challenge of chlamydia-immune cynomolgus monkeys with noninfectious, triton x-100-extracted antigen. proliferative to viable elementary bodies homologous to the original infecting serovar were demonstrated. in addition, in vitro production of antichlamydial antibody by conjunctival b cells was demonstrated by enzyme-linked immunosorbent a ... | 1989 | 2476396 |
| origins of the renal innervation in the primate, macaca fascicularis. | the origins of the renal efferent and afferent nerves in 5 cynomolgus monkeys (macaca fascicularis) were studied by using the retrograde transport of horseradish peroxidase (hrp) and horseradish peroxidase-wheat germ agglutinin (hrp-wga). the cut ends of the right renal nerves were soaked for 30-45 min in solutions consisting of 15% hrp and 1% hrp-wga. three or four days later the animals were killed and the tissues examined for the presence of retrogradely labeled neurons, hrp-filled cells were ... | 1989 | 2476474 |
| responses from dorsal column nuclei (dcn) in the monkey to stimulation of upper and lower limbs and spinal cord. | responses from the dorsal surface of the exposed dorsal column nuclei (dcn) in baboons and a monkey (macaca fascicularis) were recorded in response to electrical stimulation of the posterior tibial nerve at the ankle, the common peroneal nerve at the knee, the sciatic nerve, the spinal cord at t10, and the median nerve at the wrist. recordings of far-field potentials from the vertex with a non-cephalic reference were made before exposing the dcn and simultaneously with recordings from the dcn. t ... | 1989 | 2477221 |
| morphological substrate for eyelid movements: innervation and structure of primate levator palpebrae superioris and orbicularis oculi muscles. | the levator palpebrae superioris and orbicularis oculi are antagonistic muscles that function during movements of the eyelid. the levator also functions in conjunction with superior and inferior rectus muscles in coordinated eye/lid movements. the present study examined the innervation and morphology of these muscles in cynomolgous monkeys (macaca fascicularis) in order to provide a better understanding of the anatomical substrate for lid movements. motoneurons innervating the levator and orbicu ... | 1989 | 2477400 |
| characterization of coaggregation between bacteroides gingivalis t22 and fusobacterium nucleatum t18. | bacterial adherence is a key factor in the colonization of the oral ecosystem, yet little is known about the mechanisms by which the pathogen bacteroides gingivalis adheres in the periodontal environment. we examined the ability of strains of b. gingivalis to coaggregate with selected microorganisms isolated from the subgingival microbiota of the cynomolgus monkey. a strong interaction was demonstrated between strains of b. gingivalis and fusobacterium nucleatum, whereas less pronounced or no in ... | 1989 | 2478473 |
| brain and plasma kinetics of the opioid 11c-hydromorphone in two macaque species. | the regional brain kinetics of the opioid receptor agonist, hydromorphone, labelled with 11c, were studied with positron emission tomography in two macaque species. rhesus and cynomolgus monkeys. the plasma kinetics of 11c-hydromorphone was simultaneously determined. rapid plasma elimination was obvious in both monkey species. brain radioactivity was generally low in both, but 1.4 times higher in the rhesus than in the cynomolgus monkey brain. this observation might explain the more rapid develo ... | 1989 | 2478994 |
| transient projection from the superior temporal sulcus to area 17 in the newborn macaque monkey. | area 17 in the neonate of numerous species receives projections from cortical areas that do not project to area 17 in the adult. to investigate if this were the case in the developing primate, we have made injections of retrograde tracers in area 17 of newborn monkeys (macaca irus) and examined the areal distribution of labeled neurons. neurons projecting to area 17 were found to be restricted to those cortical regions that project to area 17 in the adult. the projection to area 17 in the neonat ... | 1989 | 2479015 |
| induction of metachromasia in experimentally induced hyperplastic/hypertrophic changes in the prostate of the cynomolgus monkey (macaca fascicularis). | metachromasia has been shown to be a stromal marker for human benign prostatic hyperplasia (bph). so far, it is not known whether comparable changes can be demonstrated in experimentally induced bph in the dog or in a subhuman primate species. in the present study, the phenomenon of metachromasia could be demonstrated in the prostate of cynomolgus monkeys, too. the reaction was quantitatively intensified by the treatment with androstenedione--an aromatizable androgen which caused hyperplastic an ... | 1989 | 2479780 |
| prostatic basal cell hyperplasia in a cynomolgus monkey (macaca fascicularis). | 1989 | 2480022 | |
| the influence of heart rate on coronary artery atherosclerosis. | elevated "casual" heart rate (hr) has been found to be an independent predictor of coronary heart disease (chd) in human beings. the current study provides data on the association between coronary artery atherosclerosis (caa) and naturally occurring individual differences in the casual hrs of cynomolgus macaques (macaca fascicularis). the data demonstrate that naturally occurring differences in casual hr are related to caa (plaque area in mm) with high hr monkeys having lesions more than twice a ... | 1987 | 2481158 |
| purification, cloning and nucleotide sequence determination of cynomolgus monkey apolipoprotein c-ii: comparison to the human sequence. | we have purified apolipoprotein c-ii (apo c-ii) from cynomolgus monkey plasma, prepared antibody against it and used the antibody to isolate a cdna containing the complete coding sequence for cynomolgus monkey apo c-ii. sequence analysis indicated that the monkey apo c-ii cdna was 200 bp longer than the human and the difference in size was all in the 5 degrees untranslated region of mrna. this was confirmed by northern analysis of human and monkey rna. there was an open reading frame in the monk ... | 1989 | 2481808 |
| ru 486 induced suppression of placental neutrophil elastase inhibitor levels. | after administration of ru 486 to pregnant cynomolgus monkeys, placental morphology varied from normal to pathological. in all cases (n = 5) circulating and placental papp-a levels were markedly suppressed by 76.0 per cent and 55.5 per cent, respectively. when fetal demise occurred within 24 h prior to caesarian section, morphological changes consistent with an active inflammatory (polymorphonuclear leukocytosis) reaction was readily observed at the utero-placental interface, degrading the chori ... | 1989 | 2481855 |
| ru 486 mediated leukocytic inflammatory reaction at the utero-placental interface. | placentae obtained from ru 486 treated cynomolgus monkeys, with successful pregnancy outcome, could not be distinguished, by microscopic or macroscopic examination, from normal placental morphology of untreated females. however, circulating papp-a levels were markedly depressed in ru 486 treated (114.8 +/- 13.1 iu/l) than in control animals (477.2 +/- 150 iu/l), suggesting compromised placental physiology. microscopic examination of placental tissue obtained from animals with fetal demise, after ... | 1989 | 2483046 |
| tissue distribution of rnas for cystatins, histatins, statherin, and proline-rich salivary proteins in humans and macaques. | the tissue distribution of the mrnas for a number of salivary proteins [proline-rich proteins (prps), statherin, cystatins, and the histatins] has been examined in humans and macaques in order to investigate their possible functions and tissue-specific regulation. we have shown that prp rnas (0.8-1.5 kb) are expressed in human and rhesus parotid and submandibular glands, and in the human bronchus. the genes for the acidic and basic prps are differentially regulated in these tissues. rnas for aci ... | 1989 | 2483725 |
| effect of thromboxane antagonism on recanalization during streptokinase-induced thrombolysis in anesthetized monkeys. | the effect of a selective thromboxane a2 (txa2) receptor antagonist, sq 30,741, on streptokinase-induced thrombolysis was examined in pentobarbital-anesthetized cynomolgus monkeys. the intimal surface of a stenosed carotid artery was stimulated with 100 microa anodal current to produce an occlusive thrombus. after 45 min of zero blood flow, a 1-h intraarterial (i.a.) infusion of streptokinase (680 u/min) was injected proximal to the thrombus. five minutes before streptokinase (sk) intravenous (i ... | 1989 | 2484079 |
| comparison of systemic and local immune responses after multiple pulmonary antigen exposures. | both systemic and local immune responses were evaluated in five male cynomolgus monkeys after a primary and multiple secondary challenges of the lung with sheep red blood cell (srbc) antigen. comparisons of peripheral blood and pulmonary antibody-forming cell (afc) responses were made after primary and multiple secondary intrapulmonary challenges with srbc. the primary immune response to srbc was characterized by a low lung to blood afc ratio. this ratio, however, increased successively with eac ... | 1989 | 2484300 |
| neuropeptide y (npy)-like immunoreactive nerve fibers in the human and monkey (macaca fascicularis) kidney. | nerve fibers immunoreactive for neuropeptide y (npy) are demonstrated for the first time by the indirect immunofluorescence technique in the human and monkey kidney. npy-like immunoactivity (npy-li) is shown in a bundle of nerve fibers in the surrounding connective tissue of arteries and to a lesser extent, veins, mainly at the juxtamedullary region. varicose nerve terminals are shown associated with blood vessels and passing between tubules in the mid and lower cortex. npy-li nerve fibers are a ... | 1989 | 2485887 |
| comparison of human and monkey retinal photoreceptor sampling mosaics. | we test the hypothesis that the diameters of foveal and near-foveal rods and cones for one well-studied human photoreceptor mosaic and one well-studied monkey photoreceptor mosaic (macaca fascicularis) are scaled relative to focal length. we conclude that this hypothesis is not supported. rather than being scaled proportionally, the sizes of the rods and cones, respectively, are nearly equivalent for both the human and monkey resulting in an effectively finer retinal grain for the larger human e ... | 1989 | 2487108 |
| [three-dimensional structure of the connective tissue core of the lingual papillae in the crab-eating macaque (macaca fascicularis)]. | the three-dimensional structure of the connective tissue core (ctc) of the four types of lingual papillae of the crab-eating macaque (macaca fascicularis) was studied by scanning electron microscopy after removal of the epithelial cell layer by long-term treatment with hydrochloric acid at room temperature and compared with the results obtained from light microscopy. 1) filiform papillae are densely distributed on the dorsal surface of the anterior two thirds of the tongue. fungiform papillae ar ... | 1989 | 2489345 |
| [establishment of clinically healthy gingiva in macaca irus]. | the purpose of this study was to assess the methods of establishing of clinically (experimental) healthy gingiva and to evaluate the status of healthy gingiva in macaca irus. three monkeys (2 males and 1 female) were used. after preliminary feeding with hard food for 6 months, plaque control procedures (scrubbing method, modified stillman method, and flossing) were started. frequency of plaque removal was three times per week under ketalar (sankyo, co. tokyo), dissociative anesthesia. we also mo ... | 1989 | 2489538 |
| metabolic function of intraportal and intrasplenic islet autografts in cynomolgus monkeys. | intraportal islet autografting can restore near-normal glucose homeostasis in large diabetic animals, but the long-term failure rate of such grafts remains high. to assess the effect of the site of transplantation, we compared the hormonal responses to glucose (500 mg/kg i.v.) of intraportal (ip) and intrasplenic (is) islet autografts in the cynomolgus monkey previously rendered diabetic by total pancreatectomy. intravenous glucose tolerance tests (ivgtts) 6 wk after ip grafting (n = 10) demonst ... | 1989 | 2492001 |
| effects of aging on the in vivo release of thyrotropin (tsh), triiodothyronine, and thyroxine induced by tsh-releasing hormone in the cynomolgus monkey (macaca fascicularis). | we demonstrated the usefulness of the human tsh immunoradiometric assay for the measurement of cynomolgus monkey serum samples, and investigated the age-related changes in serum levels of tsh, t3, and t4, in laboratory-bred cynomolgus monkeys. in the females, age-related decrease in the serum tsh concentration was not observed, but decreases in serum t3 (2.1-1.4 ng/ml) and t4 (59-48 ng/ml) were observed. however, the serum t4 level of the oldest group (19 yr old) significantly increased as compa ... | 1989 | 2492925 |
| sister chromatid exchange in chronic ethylene oxide-exposed primates: unexpected effects of in vitro culture duration, incubation temperature, and serum supplementation. | ethylene oxide (eto), a potent monofunctional dna alkylating agent, has been shown to induce sister chromatid exchanges (sce) in the peripheral blood lymphocytes of animals and workers exposed to it in vivo. we have previously reported that elevations of sce persist for 6 years after cessation of eto exposure in cynomolgus monkeys chronically exposed to eto; the elevation in mean sce was entirely attributable to a subpopulation of high sce frequency cells (hfcs). we now report that the detection ... | 1989 | 2493984 |
| pancreatic islet allo- and xenotransplantation in cynomolgus monkeys. | 1989 | 2495686 | |
| monoclonal antibody to neurofilament protein (smi-32) labels a subpopulation of pyramidal neurons in the human and monkey neocortex. | a monoclonal antibody that recognizes a nonphosphorylated epitope on the 168 kda and 200 kda subunits of neurofilament proteins has been used in an immunohistochemical study of cynomolgus monkey (macaca fascicularis) and human neocortex. this antibody, smi-32, primarily labels the cell body and dendrites of a subset of pyramidal neurons in both species. a greater proportion of neocortical pyramidal neurons were smi-32 immunoreactive (ir) in the human than in the monkey. smi-32-ir neurons exhibit ... | 1989 | 2496154 |
| rapid and profound suppression of messenger ribonucleic acid encoding follicle-stimulating hormone beta by inhibin from primate sertoli cells. | we showed previously that inhibin, partially purified from cynomolgus monkey sertoli cell culture medium (primate sertoli cell inhibin referred to as psci), selectively suppressed basal fsh secretion from dispersed rat pituitary cells and decreased total cellular fsh, but not lh content, suggesting a decrease in fsh biosynthesis. in order to investigate the mechanism of action of inhibin at the molecular level, we have now examined the effects of psci on steady state levels of the subunit mrnas ... | 1989 | 2496304 |
| "sunday start" multiphasic oral contraception: ovulation prevention and delayed follicular atresia in primates. | utilization of the "sunday start" method for oral contraceptive therapy can result in the initiation of oral contraceptive administration as late as day 6 of the ovarian/menstrual cycle. potentially, "breakthrough" ovulations could occur due to rapid follicular progression, especially if the dominant follicle is overtly established prior to the onset of estrogen-progestin administration. here, we examined the efficacy of two new oral contraceptive regimens on potential "breakthrough" ovulations ... | 1989 | 2496952 |
| purification and characterization of cytochromes p-450 from liver microsomes of 3-methylcholanthrene-treated crab-eating monkeys. | two forms of cytochrome p-450 (p-450mc1 and p-450mc2) were purified from liver microsomes of crab-eating monkeys (macaca irus) treated with 3-methylcholanthrene (mc). monkey p-450mc1 preparation had a specific content of 14.0 nmol/mg protein and showed a main protein band with a minimum molecular weight of 52,000 on sodium dodecyl sulfate-polyacrylamide gel electrophoresis. monkey p-450mc2 preparation had a specific content of 12.1 nmol/mg protein and a minimum molecular weight of 54,000. the ca ... | 1989 | 2498302 |
| brain and tissue levels of mercury after chronic methylmercury exposure in the monkey. | estimated half-lives of mercury following methylmercury exposure in humans are 52-93 d for whole body and 49-164 d for blood. in its most recent 1980 review, the world health organization concluded that there was no evidence to suggest that brain half-life differed from whole-body half-life. in the present study, female monkeys (macaca fascicularis) were dosed for at least 1.7 yr with 10, 25, or 50 micrograms/kg.d of mercury as methylmercuric chloride. dosing was discontinued, and blood half-lif ... | 1989 | 2499694 |
| application of a monoclonal antibody to a comparative study of alpha-lactalbumins from various species. | a monoclonal antibody to bovine alpha-lactalbumin was prepared and purified. the binding ability of alpha-lactalbumin from different species (cow, goat, giraffe, horse, pig, human, monkey, and guinea pig) was examined by a competitive radioimmunoassay. the order in strength of the binding affinity was cow goat, giraffe, horse, cynomolgus monkey and human, pig, and guinea pig. the order of evolutional divergence calculated from the amino acid composition was cow, goat, giraffe, horse, pig, guinea ... | 1989 | 2501365 |
| enterically transmitted non-a, non-b hepatitis in cynomolgus monkeys: morphology and probable mechanism of hepatocellular necrosis. | two cynomolgus monkeys were inoculated with a stool extract originally derived from patients suffering from enterically transmitted non-a, non-b hepatitis. subsequently, the primates developed self-limiting acute hepatitis and their liver tissues were obtained sequentially by needle biopsy or at sacrifice. histologically, the liver tissues exhibited necroinflammation which appeared in parallel, both in time and magnitude, with elevation in serum aminotransferases. necroinflammation was character ... | 1989 | 2501612 |
| apolipoprotein a-i metabolism in cynomolgus monkey. identification and characterization of beta-migrating pools. | fresh plasma from control (c) and hypercholesterolemic (hc) cynomolgus monkeys was analyzed by agarose electrophoresis-immunoblotting with antibody to cynomolgus monkey apolipoprotein (apo) a-i. two bands were evident on the autoradiogram: an alpha-migrating band (high density lipoprotein) and a beta-migrating band that comigrated exactly with cynomolgus monkey low density lipoprotein (ldl). the presence of beta-migrating apo a-i in the plasma of these monkeys was confirmed by geon-pevikon prepa ... | 1989 | 2502105 |
| contraceptive potential of ru 486 by ovulation inhibition: i. pituitary versus ovarian action with blockade of estrogen-induced endometrial proliferation. | in previous studies, ru 486 administration arrested spontaneous folliculogenesis. to investigate the central versus peripheral effects of ru 486 on the ovarian/menstrual cycle, including endometrial proliferation, ru 486 was administered daily (10 mg/kg/day, im) from menstrual cycle day 3 or 7 to day 25 in normal adult cynomolgus monkeys receiving hmg treatment (37.5 iu/day) from days 3-8 (n = 6). ru 486 administration with hmg/hcg therapy did not inhibit ovarian response, as evidenced by steroi ... | 1989 | 2503296 |
| contraceptive potential of ru 486 by ovulation inhibition: iii. preliminary observations on once weekly oral administration. | acute administration of the potent progesterone antagonist ru 486 during the luteal/secretory phase of the menstrual cycle induces premature menses in women and monkeys. using a variety of regimens, administration of ru 486 during the follicular/proliferative phase causes anovulation and amenorrhea. single treatment in the late follicular phase blocks the preovulatory lh surge and ovulation; mid-luteal phase administration of ru 486 can cause premature luteolysis. the objective of the present st ... | 1989 | 2503298 |
| histomorphometric evaluation of stress shielding in mandibular continuity defects treated with rigid fixation plates and bone grafts. | histomorphometric techniques were used to evaluate the stress shielding effect in bilateral bone grafts in 4 macaca fascicularis monkeys. bilateral continuity defects were created and grafted by replacing the resected portion of the mandible and iliac crest bone into the defect area. both sides were plated with rigid internal fixation plates. three months after bone grafting, the plate was removed from one side while the other plate was left in place. the animals were sacrificed at 1, 4, 6, and ... | 1989 | 2503580 |
| a proliferative inflammation in the mandible caused by implantation of an infected dental root. a possible experimental model for chronic osteomyelitis. | in order to provide a better understanding of the reactions of bone affected by an infectious stimulus, infected dental roots were implanted into the mandibular bone of 5 monkeys (macaca fascicularis). the roots were infected by micro-organisms belonging to the monkeys' oral plaque flora. following an observation period of 6 months, the monkeys were sacrificed. the mandibles were dissected. radiographs were taken and then the mandibles were prepared for histology. in the mandibles where the infe ... | 1989 | 2503582 |
| prostaglandin production by cultured cynomolgus monkey trabecular meshwork cells. | monkey trabecular meshwork (mtm) cells synthesize a variety of prostaglandins, including large amounts of prostaglandin e2 (pge2) and smaller amounts of 6-keto-pgf1 alpha and pgf2 alpha. the predominance of pge2 production by the mtm cells is similar to that observed in human trabecular meshwork cells. in contrast, the relative amounts of 6-keto-pgf1 alpha and pgf2 alpha were reversed compared with the human cells. the mtm cells produced increased amounts of pge2 in response to treatment with br ... | 1989 | 2503838 |
| in vitro drug metabolism and pharmacokinetics of diazepam in cynomolgus monkey hepatocytes during culture for six days. | diazepam (dz), n-desmethyl diazepam (nor) and temazepam (tem) were used as substrates in drug metabolism studies to characterize the changes in cytochrome p-450 mono-oxygenase pathways in hepatocytes isolated from cynomolgus monkeys, during culture for 6 days. hepatocytes were incubated with dz (20 microm), nor (6 microm) or tem (20 microm) for 3 hr at 3, 24, 48, 96 and 144 hr post-isolation in culture, and the profiles of disappearance of dz, as substrate, and appearance of its metabolites dete ... | 1989 | 2504170 |
| vascular responses to leukocyte products in atherosclerotic primates. | little is known about the possible role of leukocytes in the pathogenesis of vasospasm. we hypothesized that vasoactive products released by leukocytes might produce constriction of atherosclerotic arteries. to test this hypothesis, we infused fmet-leu-phe (fmlp), a peptide that activates leukocytes to release their vasoactive products, into the perfused hind limb of normal and atherosclerotic cynomolgus monkeys. infusion of fmlp did not change resistance of large arteries in normal monkeys. in ... | 1989 | 2507195 |
| recombinant human activin-a stimulates basal fsh and gnrh-stimulated fsh and lh release in the adult male macaque, macaca fascicularis. | activin-a is a homodimer of the beta a inhibin subunit that stimulates fsh secretion by pituitary cells in vitro; however, the physiological relevance of this effect is unknown. we have examined whether recombinant human activin-a (activin-a; 80 micrograms/kg/day iv infusion for 50.5 h) has in vivo bioactivity in the adult male macaque (n = 5). serum fsh and lh bioactivity and serum testosterone (t) levels were measured on 2 control days and after 24 and 48 h of activin-a administration. basal f ... | 1989 | 2507298 |
| the putative and demonstrated miotic effects of prostaglandins in mammals. | the foregoing clearly indicates that there are tremendous differences in the responsiveness of the iris sphincters of different mammalian species to the miotic effects of pgs. the iris sphincter of cats and dogs contracts in response to pgf2 alpha, but not in response to other pgs, at concentrations that can be expected to occur under in vivo physiological conditions. in both of these species, pgf2 alpha, but none of the other pgs tested, yielded a dose-dependent full miosis when applied topical ... | 1989 | 2508123 |
| effects of ovarian tissue reduction on the menstrual cycle: persistent normalcy after near-total oophorectomy. | these experiments were designed to evaluate whether removal of approximately 95% visible ovarian tissue would interrupt the short- or long-term regulation of cyclic ovarian function. on cycle days 2 4 (onset of menses = day 1), the entire left ovary and approximately 90% of the right ovary were removed from three cycling cynomolgus monkeys. after approximately 95% ovariectomy, there was an acute elevation of follicle-stimulating hormone (fsh) and luteinizing hormone (lh), which lasted 11 +/- 2 d ... | 1989 | 2508777 |
| biosynthesis of 18(rd)-hydroxyeicosatetraenoic acid from arachidonic acid by microsomes of monkey seminal vesicles. some properties of a novel fatty acid omega 3-hydroxylase and omega 3-epoxygenase. | microsomes of seminal vesicles of the cynomolgus monkey were incubated with [14c]5,8,11,14-eicosatetraenoic (arachidonic) acid and nadph for 40 min at 37 degrees c and the products were characterized. prostaglandins f2 alpha and e2 were the two main metabolites (approximately 52% of radioactivity), while 18(r)-hydroxy-cis-5,8,11,14-eicosatetraenoic acid (18(r)-hete) was identified as the main, less polar product (approximately 13%). significant biosynthesis of the 19-hydroxy or 20-hydroxy metabo ... | 1989 | 2509448 |
| stress shielding effect of rigid internal fixation plates on mandibular bone grafts. a photon absorption densitometry and quantitative computerized tomographic evaluation. | the use of rigid internal fixation reconstruction plates in combination with bone grafts provides many advantages in mandibular reconstruction. these advantages include ease of adaptability at the time of surgery as well as immediate postoperative function for the patient. disadvantages may include a "stress shielding" or disuse osteoporosis effect on the underlying bone graft as a result of the rigidity of the reconstruction plate. this study evaluated the stress shielding effects on bone graft ... | 1989 | 2509587 |
| preliminary dose finding study for subacute toxicological study of pravastatin sodium in monkeys. | pravastatin sodium was orally administered to cynomolgus monkeys at dosage levels of 50, 200 and 800 mg/kg/day for 7 successive days. excretion of diarrhea and/or loose stool were observed in the more than 50 mg/kg dose group, but the changes are quite mild. animals of the 800 mg/kg dose group showed vomiting, diarrhea and/or excretion of soft stool and reduction of cholesterol content in serum. in conclusion, it is estimated that the no effective level is less than 200 mg/kg because no abnormal ... | 1989 | 2509724 |
| subacute toxicological study in monkeys treated orally with pravastatin sodium for 5 weeks. | pravastatin sodium was administered orally to cynomolgus monkeys at dosage levels of 50, 100, 200 and 400 mg/kg/day for 5 successive weeks. five animals of 200 mg/kg and 400 mg/kg dose groups were sacrificed during the study period, because these animals deteriorated in general condition and/or showed remarkable changes in serum biochemical examination. pathological examination revealed hepatic and/or renal disturbance in these animals. these changes are thought to be the cause of deterioration ... | 1989 | 2509725 |
| the effects of fornix transection and combined fornix transection, mammillary body lesions and hippocampal ablations on object-pair association memory in the rhesus monkey. | cynomolgus monkeys were tested on an associative memory task in which they had to remember object-object pairings. eight animals (4 unoperated monkeys and 4 monkeys with lesions to components of the 'hippocampal-mammillary' circuit) were trained initially on a conditional object-pair association task that was similar to simple discrimination learning, but which involved presentation of object-pairs instead of single objects. object-pairs were made up from 4 different objects, each with an identi ... | 1989 | 2510765 |
| pancreatic islet transplantation in cynomolgus monkeys. initial studies and evidence that cyclosporine impairs glucose tolerance in normal monkeys. | using a model of streptozotocin-induced, ketosis-prone, insulin-dependent diabetes mellitus (iddm) in the cynomolgus monkey, we performed 11 intraportal transplants of collagenase-digested, ficoll-purified pancreatic islets (9 abo-compatible allografts and 2 concordant baboon xenografts). islets were pretreated with ultraviolet-b irradiation and recipients received cyclosporine a immunosuppression. two grafts never functioned, five grafts showed evidence of partial function, and four grafts (thr ... | 1989 | 2512701 |
| in vivo changes in oocyte germinal vesicle related to follicular quality and size at mid-follicular phase during stimulated cycles in the cynomolgus monkey. | histological examination of gonadotrophin stimulated macaca fascicularis ovaries removed at mid-follicular phase showed that germinal vesicles (gv) could exhibit different configurations in follicles greater than 1000 microns in diameter. we describe 3 types of nuclear organization called gv1 (dispersed and filamentous chromatin), gv2 (clumped and filamentous chromatin) and gv3 (perinucleolar chromatin condensation). gonadotrophin stimulation and follicular atresia induced modifications in gv ch ... | 1989 | 2513833 |
| experimental allergic encephalomyelitis in the monkey: humoral immunity and blood-brain barrier function. | acute monophasic experimental autoimmune encephalomyelitis (ameae) was induced in 5 macacus cynomolgus monkeys. serum and cerebrospinal fluid (csf) paired samples were collected before and four weeks after immunization, time of complete development of ameae clinical picture. after immunization the csf/serum albumin ratio and the igg index were markedly increased. agarose isoelectric focusing (aief) followed by immunofixation revealed faint igg oligoclonal bands in both serum and csf of all monke ... | 1989 | 2515167 |
| circadian rhythm of oxytocin in the cerebrospinal fluid of rhesus and cynomolgus monkeys: effects of castration and adrenalectomy and presence of a caudal-rostral gradient. | oxytocin and vasopressin (avp) were previously reported to have a diurnal rhythm in cerebrospinal fluid (csf) collected from the cervical cistern of chaired, intact male rhesus monkeys. in the present study, we continuously sampled csf from temporary indwelling catheters placed in the spinal subarachnoid space of unanesthetized monkeys maintained on tether and swivel systems. csf was collected from intact and castrate female rhesus monkeys and intact female and castrate, adrenalectomized male cy ... | 1989 | 2515462 |
| leydig cell number and function in the adult cynomolgus monkey (macaca fascicularis) is increased by daily hcg treatment but not by daily fsh treatment. | daily treatment of adult cynomolgus monkeys with 450 i.u. hcg for 16 days resulted in a significant 163% increase in the number of leydig cells, and a 9-fold rise in plasma testosterone concentrations. the number of proliferating leydig cells was very low, even after 16 days of treatment with hcg. daily fsh administration (2 injections of 15 i.u. per day) did not have any effect on the number of leydig cells or plasma testosterone values. it can be concluded, therefore, that in adult cynomolgus ... | 1989 | 2516130 |
| [first transplantation of embryonic serotonergic neurons in primate spinal cord]. | three adult monkeys (macaca fascicularis) underwent a total section of the spinal cord at thoracic level (t6). 1 week later, two of them received at t8 level an injection of a cellular suspension prepared from the raphe region of a foetal macaque 39 days old. the third animal received one injection of buffer solution. 1 month later, the animals were sacrificed, and their spinal cord was processed for the immunocytochemical detection of serotonin with light and electron microscopy. serotonergic n ... | 1989 | 2516766 |
| [stress-generated potential (sgp) on the surface of fluid-filled monkey mandible]. | previous studies have shown that stress generated potential (sgp) with bone deformation caused by orthopedic force have an important role in regulation on bone remodeling. the purpose of this study was to evaluate the effects of the chin cap on bone remodeling by elucidating the characteristics and distribution of sgp at various parts on the mandible. experiment was carried out using a mandible of macaca irus monkey which was kept in moisture with 0.9% saline. sgp was recorded using ag-agcl elec ... | 1989 | 2517758 |
| ultrastructure of the chronically vagotomised atrial myocardium in the monkey (macaca fascicularis). | the ultrastructure of the atrial myocardium in the monkey (macaca fascicularis) was studied after bilateral cervical vagotomy and survival times of 100, 175 and 367 days. changes were observed in the nucleus and the cytoplasm of the myocyte. sequestered within the nuclei of the affected myocytes were cytoplasmic organelles and inclusions. in the late stages, there was a tendency towards condensation and margination of the heterochromatin. changes in the cytoplasm included increased glycogen, mit ... | 1989 | 2520470 |
| pharmacokinetics of doxylamine given as bendectin in the pregnant monkey and baboon. | the object of the present study was to determine the maternal plasma pharmacokinetics of doxylamine (the antihistamine component of bendectin) following bendectin administration. bendectin was administered daily, po, at a dosage approximately 10 times the maximum human therapeutic dosage (7 mg/kg/day) throughout organogenesis (approximately days 22 through 50 of gestation) to three cynomolgus monkeys, four rhesus monkeys, and five baboons. two pharmacokinetic experiments were performed in each a ... | 1989 | 2520523 |
| serum hormone levels in pregnant cynomolgus monkeys. | serum levels of estradiol (e2), progesterone (p), prolactin (prl), monkey chorionic gonadotropin (mcg), dehydroepiandrosterone sulfate (dheas), and cortisol (c) in pregnant cynomolgus monkeys are described. mcg, e2, and prl patterns resembled those of pregnant rhesus monkeys. p patterns differed from data from the literature. dheas patterns did not follow e2 patterns. c levels did not change during pregnancy. | 1989 | 2523973 |
| experimental infection of cynomolgus monkeys (macaca fascicularis) with hiv-2. | ten healthy adult cynomolgus monkeys (macaca fascicularis) were inoculated with two different isolates of human immunodeficiency virus type 2 (hiv-2), sbl-6669 and sbl-k135, to establish an animal model for hiv infection. hiv-2sbl-6669 had been propagated for a long time in continuous human cell lines whereas hiv-2sbl-k135 had been grown only in fresh human and monkey lymphocyte cultures or previously for a short time in a continuous cell line. virus was isolated from three or four animals inocu ... | 1989 | 2526870 |
| effects of cocaine and related drugs in nonhuman primates. i. [3h]cocaine binding sites in caudate-putamen. | specific binding sites for [3h]cocaine were identified in caudate-putamen membranes prepared from nonhuman primate brains (macaca fascicularis and saimiri sciureus). saturation of the sites was determined in competition studies using a fixed concentration of [3h]cocaine (2.7 nm) and increasing concentrations of unlabeled cocaine (1 pm-100 microm). computer resolution of the shallow displacement curve (nh, 0.58) revealed that a two-component binding model [kd1, 19.2 nm, maximum binding1 (bmax1), ... | 2008 | 2529364 |