Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| influences of climate change on the potential distribution of lutzomyia longipalpis sensu lato (psychodidae: phlebotominae). | this study explores the present day distribution of lutzomyia longipalpis in relation to climate, and transfers the knowledge gained to likely future climatic conditions to predict changes in the species' potential distribution. we used ecological niche models calibrated based on occurrences of the species complex from across its known geographic range. anticipated distributional changes varied by region, from stability to expansion or decline. overall, models indicated no significant north-sout ... | 2017 | 28668326 |
| visceral leishmaniasis in an environmentally protected area in southeastern brazil: epidemiological and laboratory cross-sectional investigation of phlebotomine fauna, wild hosts and canine cases. | leishmaniasis is a rapidly expanding zoonosis that shows increasing urbanization. concern exists regarding the role of wildlife in visceral leishmaniasis (vl) transmission, due to frequent natural or anthropogenic environmental changes that facilitate contact between wildlife, humans and their pets. the municipality of campinas, in southeastern brazil, initially recorded vl in 2009, when the first autochthonous case was confirmed in a dog living in an upscale residential condominium, located ins ... | 2017 | 28704391 |
| the role of wing geometric morphometrics in the identification of sandflies within the subgenus lutzomyia. | the lutzomyia subgenus (diptera: psychodidae) includes sibling species with morphologically indistinguishable females. the aims of this study were to analyse variations in the size and shape of wings of species within the lutzomyia subgenus and to assess whether these analyses might be useful in their identification. wings (n = 733) of 18 species deposited in brazilian collections were analysed by geometric morphometrics, using other genera and subgenera as outgroups. shape variation was summari ... | 2017 | 28707301 |
| occurrence of lutzomyia longipalpis lutz & neiva 1912 and cerdocyon thous linnaeus 1977, in a visceral leishmaniasis endemic area in brazil. | cerdocyon thous presents a wide geographic distribution in brazil and its role as a possible leishmania infantum reservoir in a visceral leishmaniasis (vl) transmission cycle regardless of dogs (canis familiaris) has been discussed. from this perspective, this work describes the occurrence and use of the habitat by cerdocyon thous in a lutzomyia longipalpis occurrence area teresina (piaui - brazil), vl endemic region. three specimens of c. thous were monitored with the use of radio telemetry and ... | 2017 | 28712973 |
| after infection with leishmania infantum, golden hamsters (mesocricetus auratus) become more attractive to female sand flies (lutzomyia longipalpis). | in brazil, human and canine visceral leishmaniasis is caused by infection with leishmania infantum, a protist parasite transmitted by blood-feeding female lutzomyia longipalpis sand flies. the objective of this study was to determine if the odour of hamsters, infected with le. infantum, was more attractive than the odour of the same hamsters, before they were infected. the attractiveness of odour collected from individual hamsters (n = 13), before they were infected, was compared in a longitudin ... | 2017 | 28733676 |
| spatial population dynamics and temporal analysis of the distribution of lutzomyia longipalpis (lutz & neiva, 1912) (diptera: psychodidae: phlebotominae) in the city of clorinda, formosa, argentina. | lutzomyia longipalpis, the vector for the causal agent of visceral leishmaniasis (vl), has extended its distribution in the southern cone in the americas. the first urban record of lu. longipalpis in argentina was from the city of clorinda in 2004. the aim of this study was to analyse the monthly distribution and abundance of lu. longipalpis and to evaluate its association with environmental and climatic variables in clorinda city, province of formosa. | 2017 | 28743283 |
| evaluation of chemical spraying and environmental management efficacy in areas with minor previous application of integrated control actions for visceral leishmaniasis in brazil. | leishmaniases are vector-borne diseases that are transmitted to humans through the bite of leishmania-infected phlebotomine sand flies (diptera:psychodidae). the main proved vector of visceral leishmaniais (vl) in the new world - lutzomyia longipalpis - is well-adapted to urban areas and has extensive distribution within the five geographical regions of brazil. integrated public health actions directed for the vector, domestic reservoir and humans for the control of vl are preferentially applied ... | 2017 | 28760482 |
| molecular detection of wolbachia pipientis in natural populations of sandfly vectors of leishmania infantum in endemic areas: first detection in lutzomyia longipalpis. | a polymerase chain reaction-based method was used to screen sandflies for infection with wolbachia (rickettsiales: rickettsiaceae), an intracellular bacterial endosymbiont found in many arthropods and filarial hosts. positive results were obtained in five of 200 field-collected sandflies and were confirmed by sequencing. all sandflies were lutzomyia longipalpis (diptera: psychodidae) captured in a region endemic for visceral leishmaniasis in brazil. this is the first study to identify wolbachia ... | 2017 | 28799248 |
| leishmania infection and blood food sources of phlebotomines in an area of brazil endemic for visceral and tegumentary leishmaniasis. | the aims of the study were to determine the blood feeding preferences of sandflies and to identify species of leishmania that infected phlebotomines in caxias, maranhão, brazil, an area that is highly endemic for leishmaniasis. sandflies were captured in light traps located in the peridomiciliary environments of randomly selected houses in urban and rural settings between 1800 and 0600 hours on new moon days between march 2013 and february 2015. dna extracts from 982 engorged female sandflies we ... | 2017 | 28837565 |
| sand fly (diptera, psychodidae, phlebotominae) abundance and diversity in areas affected by the são francisco river transposition project in ceará state, brazil. | entomological surveillance of sand fly vectors was carried out to support leishmaniasis prevention and control measures in areas affected by the são francisco river transposition project. | 2017 | 28851424 |
| the sand fly salivary protein lufaxin inhibits the early steps of the alternative pathway of complement by direct binding to the proconvertase c3b-b. | saliva of the blood feeding sand fly lutzomyia longipalpis was previously shown to inhibit the alternative pathway (ap) of the complement system. here, we have identified lufaxin, a protein component in saliva, as the inhibitor of the ap. lufaxin inhibited the deposition of c3b, bb, properdin, c5b, and c9b on agarose-coated plates in a dose-dependent manner. it also inhibited the activation of factor b in normal serum, but had no effect on the components of the membrane attack complex. surface p ... | 2017 | 28912782 |
| dog skin parasite load, tlr-2, il-10 and tnf-α expression and infectiousness. | visceral leishmaniosis is a zoonotic disease that is transmitted by lutzomyia longipalpis sandflies. dogs are the main peri-urban reservoir of the disease, and progression of canine leishmaniosis is dependent on the type of immune response elaborated against the parasite. type 1 immunity is characterized by effective cellular response, with production of pro-inflammatory cytokines such as tumour necrosis factor alpha (tnf-α). in contrast, type 2 immunity is predominantly humoral, associated with ... | 2017 | 28929498 |
| ph control in the midgut of aedesaegypti under different nutritional conditions. | aedes aegypti is one of the most important disease vectors in the world. because their gut is the first site of interaction with pathogens, it is important to understand a. aegypti gut physiology. in this study, we investigated the mechanisms of ph control in the midgut of a. aegypti females under different nutritional conditions. we found that unfed females have an acidic midgut (ph ∼6). the midgut of unfed insects is actively maintained at ph 6 regardless of the ingestion of either alkaline or ... | 2017 | 28931720 |
| environmental suitability for lutzomyia longipalpis in a subtropical city with a recently established visceral leishmaniasis transmission cycle, argentina. | visceral leishmaniasis (vl) is an endemic disease in northeastern argentina including the corrientes province, where the presence of the vector and canine cases of vl were recently confirmed in december 2008. | 2017 | 28953995 |
| the role of gallery forests in maintaining phlebotominae populations: potential leishmania spp. vectors in the brazilian savanna. | knowledge on synanthropic phlebotomines and their natural infection by leishmania is necessary for the identification of potential areas for leishmaniasis occurrence. | 2017 | 28953996 |
| serological tests fail to discriminate dogs with visceral leishmaniasis that transmit leishmania infantum to the vector lutzomyia longipalpis. | the control of reservoirs for leishmania infantum -induced zoonotic visceral leishmaniasis requires the identification of dogs posing a population risk. here, we assessed the performance of several assays to identify lutzomyia longipalpis infectious dogs. | 2017 | 28954069 |
| new records of phlebotomine sand flies (diptera: psychodidae) from the state of alagoas, northeast of brazil. | phlebotomine sand flies are small insects of great medical importance. this study presents new records of phlebotomine sand flies, which augment the list of species, recorded in the state of alagoas, brazil. sand flies were collected using cdc miniature light traps. collections were made between november 2008 and april 2016, in 47 municipalities within the state of alagoas. twenty-seven thousand two-hundred forty-four sand flies were collected, representing 18 species in seven genera. lutzomyia ... | 2018 | 29029319 |
| immunization with ljm11 salivary protein protects against infection with leishmania braziliensis in the presence of lutzomyia longipalpis saliva. | leishmania is transmitted in the presence of sand fly saliva. protective immunity generated by saliva has encouraged identification of a vector salivary-based vaccine. previous studies have shown that immunization with ljm11, a salivary protein from lutzomyia longipalpis, is able to induce a th1 immune response and protect mice against bites of leishmania major-infected lutzomyia longipalpis. here, we further investigate if immunization with ljm11 recombinant protein is able to confer cross-prot ... | 2018 | 29037520 |
| immunization against full-length protein and peptides from the lutzomyia longipalpis sand fly salivary component maxadilan protects against leishmania major infection in a murine model. | leishmaniasis is an arthropod vectored disease causing considerable human morbidity and mortality. vaccination remains the most realistic and practical means to interrupt the growing number and diversity of sand fly vectors and reservoirs of leishmania. since transmission of leishmania is achieved exclusively by sand fly vectors via immune-modulating salivary substances, conventional vaccination requiring an unmodified host immune response for success are potentially destined to fail unless immu ... | 2017 | 29079105 |
| human competence to transmit leishmania infantum to lutzomyia longipalpis and the influence of human immunodeficiency virus infection. | visceral leishmaniasis (vl) caused by leishmania infantum is a lethal disease transmitted by sand flies. although, considered a zoonosis with dogs held as the main reservoirs, humans are also sources of infection. therefore, control policies currently focused on dog culling may need to consider that vl and human immunodeficiency virus (hiv)/vl patients may also be infectious, contributing to transmission. reservoir competence of patients with vl without and with hiv infection and of persons asym ... | 2018 | 29141704 |
| clinical and immunopathological findings during long term follow-up in leishmania infantum experimentally infected dogs. | canine visceral leishmaniasis (cvl) is caused by leishmania infantum, which in the new world is transmitted by lutzomyia longipalpis. while prospective clinical and immunological assessments of dogs experimentally challenged with l. infantum have been previously reported over a relatively short follow-up period, the long-term characterization of infected animals has not been performed to date. we evaluated dogs in a subclinical state for six years following experimental infection with l. infantu ... | 2017 | 29162847 |
| pre-clinical antigenicity studies of an innovative multivalent vaccine for human visceral leishmaniasis. | the notion that previous infection by leishmania spp. in endemic areas leads to robust anti-leishmania immunity, supports vaccination as a potentially effective approach to prevent disease development. nevertheless, to date there is no vaccine available for human leishmaniasis. we optimized and assessed in vivo the safety and immunogenicity of an innovative vaccine candidate against human visceral leishmaniasis (vl), consisting of virus-like particles (vlp) loaded with three different recombinan ... | 2017 | 29176865 |
| co-occurrence and seasonal and environmental distributions of the sandflies lutzomyia longipalpis and nyssomyia whitmani in the city of puerto iguazú, northeastern argentina. | the aim of this work was to study the distribution of phlebotominae (diptera: psycodidade) abundance in time and space in an area in northeastern argentina with vector transmission of visceral and tegumentary leishmaniasis. for this, 51 households were selected using a 'worst scenario' criterion where one light trap was set during two consecutive nights in peridomiciles in the transitions between the four seasons, and the environment was surveyed simultaneously. the relationships of phlebotomine ... | 2017 | 29178206 |
| a temporal comparison of sex-aggregation pheromone gland content and dynamics of release in three members of the lutzomyia longipalpis (diptera: psychodidae) species complex. | lutzomyia longipalpis is the south american vector of leishmania infantum, the etiologic agent of visceral leishmaniasis (vl). male l. longipalpis produce a sex-aggregation pheromone that is critical in mating, yet very little is known about its accumulation over time or factors involved in release. this laboratory study aimed to compare accumulation of pheromone over time and determine factors that might influence release in three members of the l. longipalpis species complex. | 2017 | 29194438 |
| alternative splicing originates different domain structure organization of lutzomyia longipalpis chitinases. | background the insect chitinase gene family is composed by more than 10 paralogs, which can codify proteins with different domain structures. in lutzomyia longipalpis, the main vector of visceral leishmaniasis in brazil, a chitinase cdna from adult female insects was previously characterized. the predicted protein contains one catalytic domain and one chitin-binding domain (cbd). the expression of this gene coincided with the end of blood digestion indicating a putative role in peritrophic matri ... | 2018 | 29236932 |
| lipophosphoglycan polymorphisms do not affect leishmania amazonensis development in the permissive vectors lutzomyia migonei and lutzomyia longipalpis. | lipophosphoglycan (lpg) is a dominant surface molecule of leishmania promastigotes. its species-specific polymorphisms are found mainly in the sugars that branch off the conserved gal(β1,4)man(α1)-po4 backbone of repeat units. leishmania amazonensis is one of the most important species causing human cutaneous leishmaniasis in the new world. here, we describe lpg intraspecific polymorphisms in two le. amazonensis reference strains and their role during the development in three sand fly species. | 2017 | 29246180 |
| a defined subunit vaccine that protects against vector-borne visceral leishmaniasis. | vaccine development for vector-borne pathogens may be accelerated through the use of relevant challenge models, as has been the case for malaria. because of the demonstrated biological importance of vector-derived molecules in establishing natural infections, incorporating natural challenge models into vaccine development strategies may increase the accuracy of predicting efficacy under field conditions. until recently, however, there was no natural challenge model available for the evaluation o ... | 2017 | 29263878 |
| the effect of luminous intensity on the attraction of phlebotomine sand flies to light traps. | to improve the efficiency of light traps in collecting phlebotomine sand flies, the potential effects of luminous intensity on the attraction of these insects to traps were evaluated. sand flies were collected with hooper pugedo (hp) light traps fitted with 5-mm light-emitting diodes (led) bulbs: green (520 nm wavelength-10,000, 15,000 and 20,000 millicandela (mcd) and blue (470 nm-4,000, 12,000 and 15,000 mcd). a total of 3,264 sand flies comprising 13 species were collected. the collected spec ... | 2017 | 29272438 |
| detection of leishmania dna and blood meal identification in sand flies (diptera: psychodidae) from lençois maranhenses national park region, brazil. | to elucidate portions of the transmission cycles of american tegumentary leishmaniasis (tl) and visceral leishmaniasis (vl) occurring in the region surrounding the lençóis maranhenses national park, an important tourist center in brazil, the present study objectives were to determine the rate of natural infection by leishmania spp. and the blood meal in caught sand flies species in the region. sand flies were captured over 36 mo in 62 locations of the municipality of barreirinhas, maranhão with ... | 2017 | 29281057 |
| bacterial diversity of wild-caught lutzomyia longipalpis (a vector of zoonotic visceral leishmaniasis in brazil) under distinct physiological conditions by metagenomics analysis. | the leishmaniases are a group of diseases caused by protozoans of the genus leishmania, which are transmitted by the bite of phlebotomine sand flies. in the new world, lutzomyia longipalpis is the most important vector of visceral leishmaniasis and is a proven vector for leishmania infantum chagasi in brazil. during development within the vector, leishmania can interact with a variety of microorganisms such as fungi and bacteria. the presence of bacteria in the midgut of sand flies can influence ... | 2017 | 29284535 |
| antibody response to sand fly saliva is a marker of transmission intensity but not disease progression in dogs naturally infected with leishmania infantum. | antibody responses to sand fly saliva have been suggested to be a useful marker of exposure to sand fly bites and leishmania infection and a potential tool to monitor the effectiveness of entomological interventions. exposure to sand fly bites before infection has also been suggested to modulate the severity of the infection. here, we test these hypotheses by quantifying the anti-saliva igg response in a cohort study of dogs exposed to natural infection with leishmania infantum in brazil. | 2018 | 29301571 |
| bionomic aspects of lutzomyia evansi and lutzomyia longipalpis, proven vectors of leishmania infantum in an endemic area of non-ulcerative cutaneous leishmaniasis in honduras. | some lutzomyia species are the vectors of human leishmaniasis in the americas. visceral and cutaneous leishmaniasis are both endemic in the pacific region of honduras, but the non-ulcerative form is the more frequent clinical manifestation in this region, where lutzomyia longipalpis is the most abundant and the only incriminated vector. taxonomic identification and distribution studies of sand flies are important to understand the epidemiology and to control these neglected tropical diseases. | 2018 | 29304878 |
| masp-1 of the complement system enhances clot formation in a microvascular whole blood flow model. | the complement and coagulation systems closely interact with each other. these interactions are believed to contribute to the proinflammatory and prothrombotic environment involved in the development of thrombotic complications in many diseases. complement masp-1 (mannan-binding lectin-associated serine protease-1) activates coagulation factors and promotes clot formation. however, this was mainly shown in purified or plasma-based static systems. here we describe the role of masp-1 and complemen ... | 2018 | 29324883 |
| identification of secreted proteins involved in nonspecific dsrna-mediated lutzomyia longipalpis ll5 cell antiviral response. | hematophagous insects transmit infectious diseases. sand flies are vectors of leishmaniasis, but can also transmit viruses. we have been studying immune responses of lutzomyia longipalpis, the main vector of visceral leishmaniasis in the americas. we identified a non-specific antiviral response in l. longipalpis ll5 embryonic cells when treated with non-specific double-stranded rnas (dsrnas). this response is reminiscent of interferon response in mammals. we are investigating putative effectors ... | 2018 | 29346269 |
| molecular detection of leishmania (leishmania) infantum in phlebotomine sandflies from a visceral leishmaniasis endemic area in northwestern of são paulo state, brazil. | this study identified the natural infection rate of leishmania (leishmania) infantum in lutzomyia longipalpis sandflies collected in a neighborhood around a kennel, in dracena, northwestern of são paulo state. this region is highly endemic for visceral leishmaniasis in brazil. insects were captured during 2 to 3 nights monthly for 11 months (january-november 2012) using 10 automatic light traps around a kennel in a transition between periurban and urban neighborhood. capture aimed the determinat ... | 2018 | 29373820 |