Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| isolation and characterization of faecalibacterium prausnitzii from calves and piglets. | the goal of our study was to isolate and characterize faecalibacterium prausnitzii from fecal samples of healthy calves and piglets, in order to develop a novel probiotic for livestock animals. we identified 203 isolates of faecalibacterium sp., which were clustered in 40 genetically distinct groups. one representative isolate from each cluster was selected for further characterization. the concentrations of the short chain fatty acids (scfa) acetate, butyrate, propionate and isobutyrate in the ... | 2014 | 25551453 |
| gut microbiota composition correlates with changes in body fat content due to weight loss. | genetics, lifestyle, and dietary habits contribute to metabolic syndrome, but also an altered gut microbiota has been identified. based on this knowledge it is suggested that host bacterial composition tends to change in response to dietary factors and weight loss. the aim of this study was to identify bacteria affecting host metabolism in obesity during weight loss and to correlate them with changes of the body composition obtained from bioelectrical impedance analysis (bia). we recruited obese ... | 2015 | 25609655 |
| manipulating the gut microbiota to maintain health and treat disease. | the intestinal microbiota composition varies between healthy and diseased individuals for numerous diseases. although any cause or effect relationship between the alterations in the gut microbiota and disease is not always clear, targeting the intestinal microbiota might offer new possibilities for prevention and/or treatment of disease. | 2015 | 25651995 |
| high amount of dietary fiber not harmful but favorable for crohn disease. | current chronic diseases are a reflection of the westernized diet that features a decreased consumption of dietary fiber. indigestible dietary fiber is metabolized by gut bacteria, including faecalibacterium prausnitzii, to butyrate, which has a critical role in colonic homeostasis owing to a variety of functions. dietary fiber intake has been significantly inversely associated with the risk of chronic diseases. crohn disease (cd) is not an exception. however, even authors who reported the inver ... | 2015 | 25663207 |
| review on microbiota and effectiveness of probiotics use in older. | the aim of the present systematic review is to summarize the existing knowledge about the human microbiota in the elderly and the effects of probiotics in elderly population. the elderly subjects, compared to adult population, show a reduction in the diversity of the microbiota, characterized by a large interindividual variability, with lower numbers of firmicutes, bifidobacteria, clostridium cluster xiv, faecalibacterium prausnitzii, blautia coccoides-eubacterium rectal and higher presence of e ... | 2015 | 25685762 |
| red wine consumption is associated with fecal microbiota and malondialdehyde in a human population. | red wine intake has been associated with a lower risk of cardiovascular disease; its polyphenol content is the primary cause of antioxidant and anti-inflammatory properties attributed to this beverage. however, the way in which these activities are exerted is not yet clear, although some authors have proposed that intestinal microbiota could be implicated. | 2015 | 25738317 |
| increased gut microbiota diversity and abundance of faecalibacterium prausnitzii and akkermansia after fasting: a pilot study. | an impaired gut microbiota has been reported as an important factor in the pathogenesis of obesity. weight reduction has already been mentioned to improve gut microbial subpopulations involved in inflammatory processes, though other subpopulations still need further investigation. thus, weight reduction in the context of a fasting program together with a probiotic intervention may improve the abundance and diversity of gut microbiota. | 2015 | 25763563 |
| monosodium l-glutamate and dietary fat differently modify the composition of the intestinal microbiota in growing pigs. | the chinese have been undergone rapid transition to a high-fat diet-consuming lifestyle, while monosodium l-glutamate (msg) is widely used as a daily food additive. it has been reported that fat alters the composition of intestinal microbiota. however, little information is available on the effects of oral msg on intestinal microbiota, and no study was done focusing on the interaction effect of fat and msg with respect to intestinal microbiota. the present study thus aimed to determine the effec ... | 2015 | 25791341 |
| [quantitation of intestinal fusobacterium and butyrate- producing bacteria in patients with colorectal adenomas and colorectal cancer]. | to compare the abundance of 16s rrna gene of intestinal fusobacterium and butyrate-producing bacteria in patients with colorectal adenomas patients and colorectal cancer and to reveal the correlation between the target bacteria and the development of colorectal cancer. | 2014 | 25803901 |
| gut microbiota and tacrolimus dosing in kidney transplantation. | tacrolimus dosing to establish therapeutic levels in recipients of organ transplants is a challenging task because of much interpatient and intrapatient variability in drug absorption, metabolism, and disposition. in view of the reported impact of gut microbial species on drug metabolism, we investigated the relationship between the gut microbiota and tacrolimus dosing requirements in this pilot study of adult kidney transplant recipients. serial fecal specimens were collected during the first m ... | 2015 | 25815766 |
| recent advances in characterizing the gastrointestinal microbiome in crohn's disease: a systematic review. | the intestinal microbiota is involved in the pathogenesis of inflammatory bowel disease. a reduction in the diversity of the intestinal microbiota as well as specific taxonomic and functional shifts have been reported in crohn's disease and may play a central role in the inflammatory process. the aim was to systematically review recent developments in the structural and functional changes observed in the gastrointestinal microbiome in patients with crohn's disease. | 2015 | 25844959 |
| siblings of patients with crohn's disease exhibit a biologically relevant dysbiosis in mucosal microbial metacommunities. | to determine the existence of mucosal dysbiosis in siblings of patients with crohn's disease (cd) using 454 pyrosequencing and to comprehensively characterise and determine the influence of genotypical and phenotypical factors, on that dysbiosis. siblings of patients with cd have elevated risk of developing cd and display aspects of disease phenotype, including faecal dysbiosis. whether the mucosal microbiota is disrupted in these at-risk individuals is unknown. | 2016 | 25856344 |
| faecalibacterium prausnitzii prevents physiological damages in a chronic low-grade inflammation murine model. | the human gut houses one of the most complex and abundant ecosystems composed of up to 10(13)-10(14) microorganisms. the importance of this intestinal microbiota is highlighted when a disruption of the intestinal ecosystem equilibrium appears (a phenomenon called dysbiosis) leading to an illness status, such as inflammatory bowel diseases (ibd). indeed, the reduction of the commensal bacterium faecalibacterium prausnitzii (one of the most prevalent intestinal bacterial species in healthy adults) ... | 2015 | 25888448 |
| identification of metabolic signatures linked to anti-inflammatory effects of faecalibacterium prausnitzii. | faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified on the basis of human clinical data. the mechanisms underlying its beneficial effects are still unknown. gnotobiotic mice harboring f. prausnitzii (a2-165) and escherichia coli (k-12 jm105) were subjected to 2,4,6-trinitrobenzenesulfonic acid (tnbs)-induced acute colitis. the inflammatory colitis scores and a gas chromatography-time of flight (gc/tof) mass spectrometry-based metabolomic profile were monitored in ... | 2015 | 25900655 |
| faecalibacterium prausnitzii strain htf-f and its extracellular polymeric matrix attenuate clinical parameters in dss-induced colitis. | a decrease in the abundance and biodiversity of intestinal bacteria within the firmicutes phylum has been associated with inflammatory bowel disease (ibd). in particular, the anti-inflammatory bacterium faecalibacterium prausnitzii, member of the firmicutes phylum and one of the most abundant species in healthy human colon, is underrepresented in the microbiota of ibd patients. the aim of this study was to investigate the immunomodulatory properties of f. prausnitzii strain a2-165, the biofilm f ... | 2015 | 25910186 |
| bacillus coagulans gbi-30, 6086 modulates faecalibacterium prausnitzii in older men and women. | advancing age is linked to a decrease in beneficial bacteria such as bifidobacterium spp. and reduced aspects of innate immune function. | 2015 | 25948780 |
| intestinal microbiota and allergic diseases: a systematic review. | evidence suggests that possible imbalances in intestinal microbiota composition may be implicated in the occurrence of allergic diseases. although several studies published until 2006 indicated a correlation between microbiota composition and allergic symptoms, it has not been possible to distinguish protective microorganisms from those associated with increased risk of allergic diseases. therefore, the objective of this study was to review the studies published since 2007 that address the intes ... | 2016 | 25985709 |
| the intestinal microbiome in spondyloarthritis. | microbial dysbiosis in the gut is emerging as a common component in various inflammatory disorders including spondyloarthritis (spa). the depth of this influence has begun to be realized with next-generation sequencing of the gut microbiome providing unbiased assessment of previously uncharted bacterial populations. | 2015 | 26002022 |
| identification of an anti-inflammatory protein from faecalibacterium prausnitzii, a commensal bacterium deficient in crohn's disease. | crohn's disease (cd)-associated dysbiosis is characterised by a loss of faecalibacterium prausnitzii, whose culture supernatant exerts an anti-inflammatory effect both in vitro and in vivo. however, the chemical nature of the anti-inflammatory compounds has not yet been determined. | 2016 | 26045134 |
| specific gut microbiota features and metabolic markers in postmenopausal women with obesity. | gut microbial gene richness and specific bacterial species are associated with metabolic risk markers in humans, but the impact of host physiology and dietary habits on the link between the gut microbiota and metabolic markers remain unclear. the objective of this study was to identify gut metagenomic markers associated with estimates of insulin resistance, lipid metabolism and inflammation in obesity, and to explore whether the associations between metagenomic and metabolic markers persisted af ... | 2015 | 26075636 |
| randomised clinical trial: gut microbiome biomarkers are associated with clinical response to a low fodmap diet in children with the irritable bowel syndrome. | a low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (fodmap) diet can ameliorate symptoms in adult irritable bowel syndrome (ibs) within 48 h. | 2015 | 26104013 |
| structural analysis of a class iii preq1 riboswitch reveals an aptamer distant from a ribosome-binding site regulated by fast dynamics. | preq1-iii riboswitches are newly identified rna elements that control bacterial genes in response to preq1 (7-aminomethyl-7-deazaguanine), a precursor to the essential hypermodified trna base queuosine. although numerous riboswitches fold as h-type or hlout-type pseudoknots that integrate ligand-binding and regulatory sequences within a single folded domain, the preq1-iii riboswitch aptamer forms a hlout-type pseudoknot that does not appear to incorporate its ribosome-binding site (rbs). to unde ... | 2015 | 26106162 |
| hydrodynamic chronoamperometry for probing kinetics of anaerobic microbial metabolism--case study of faecalibacterium prausnitzii. | monitoring in vitro the metabolic activity of microorganisms aids bioprocesses and enables better understanding of microbial metabolism. redox mediators can be used for this purpose via different electrochemical techniques that are either complex or only provide non-continuous data. hydrodynamic chronoamperometry using a rotating disc electrode (rde) can alleviate these issues but was seldom used and is poorly characterized. the kinetics of faecalibacterium prausnitzii a2-165, a beneficial gut m ... | 2015 | 26127013 |
| anti-tumour necrosis factor treatment with adalimumab induces changes in the microbiota of crohn's disease. | the composition of the intestinal microbiota is altered in crohn's disease [cd] patients. the objective of this study was to evaluate the qualitative and quantitative changes in the microbiota of cd patients in 3 months of treatment with adalimumab [ada], and determine whether or not these changes are produced towards the recovery of the normal, healthy-like microbiota. | 2015 | 26142465 |
| (1)h nmr spectroscopy of fecal extracts enables detection of advanced colorectal neoplasia. | colorectal cancer (crc) is a growing cause of mortality in developing countries, warranting investigation into its etiopathogenesis and earlier diagnosis. here, we investigated the fecal metabolic phenotype of patients with advanced colorectal neoplasia and controls using (1)h-nuclear magnetic resonance (nmr) spectroscopy and multivariate modeling. the fecal microbiota composition was assessed by quantitative real-time pcr as well as wif-1 methylation levels in stools, serum, and urine and corre ... | 2015 | 26211820 |
| in vitro fermentation of lupin seeds (lupinus albus) and broad beans (vicia faba): dynamic modulation of the intestinal microbiota and metabolomic output. | broad beans (vicia faba) and lupin seeds (lupinus albus) are legumes rich in a wide range of compounds, which may represent a useful dietary approach for modulating the human gut microbiome. in this work, after in vitro digestion, legume samples were used as carbon sources in anaerobic batch cultures to evaluate their impact on the intestinal microbiota composition and on their metabolic products. the fermentations were monitored by a decrease in ph, generation of short chain fatty acids (scfa) ... | 2015 | 26252418 |
| crohn associated microbial communities associated to colonic mucosal biopsies in patients of the western mediterranean. | next generation sequencing approaches allow the retrieval of several orders of magnitude larger numbers of amplified single sequences in 16s rrna diversity surveys than classical methods. however, the sequences are only partial and thus lack sufficient resolution for a reliable identification. the opu approach used here, based on a tandem combination of high quality 454 sequences (mean >500 nuc) applying strict otu thresholds, and phylogenetic inference based on parsimony additions to preexistin ... | 2015 | 26275394 |
| mucosa-associated faecalibacterium prausnitzii phylotype richness is reduced in patients with inflammatory bowel disease. | faecalibacterium prausnitzii depletion in intestinal diseases has been extensively reported, but little is known about intraspecies variability. this work aims to determine if subjects with gastrointestinal disease host mucosa-associated f. prausnitzii populations different from those hosted by healthy individuals. a new species-specific pcr-denaturing gradient gel electrophoresis (pcr-dgge) method targeting the 16s rrna gene was developed to fingerprint f. prausnitzii populations in biopsy spec ... | 2015 | 26296733 |
| equol status and changes in fecal microbiota in menopausal women receiving long-term treatment for menopause symptoms with a soy-isoflavone concentrate. | the knowledge regarding the intestinal microbial types involved in isoflavone bioavailability and metabolism is still limited. the present work reports the influence of a treatment with isoflavones for 6 months on the fecal bacterial communities of 16 menopausal women, as determined by culturing and culture-independent microbial techniques. changes in fecal communities were analyzed with respect to the women's equol-producing phenotype. compared to baseline, at 1 and 3 months the counts for all ... | 2015 | 26300856 |
| faecal proteomics: a tool to investigate dysbiosis and inflammation in patients with cystic fibrosis. | several microbial studies reported gut microbiota dysbiosis in patients with cystic fibrosis (cf). the functional consequences of this phenomenon are poorly understood. faecal metaproteomics allows the quantitative analysis of host and microbial proteins to address functional changes resulting from this dysbiosis. | 2016 | 26330184 |
| the microbiota shifts the iron sensing of intestinal cells. | the amount of iron in the diet directly influences the composition of the microbiota. inversely, the effects of the microbiota on iron homeostasis have been little studied. so, we investigate whether the microbiota itself may alter host iron sensing. duodenal cytochrome b and divalent metal transporter 1, involved in apical iron uptake, are 8- and 10-fold, respectively, more abundant in the duodenum of germ-free (gf) mice than in mice colonized with a microbiota. in contrast, the luminal exporte ... | 2016 | 26370847 |
| the gut microbial community in metabolic syndrome patients is modified by diet. | intestinal microbiota changes may be involved in the development of metabolic syndrome (mets), which is a multicomponent disorder frequently associated with obesity. the aim of this study was to test the effect of consuming two healthy diets: a mediterranean diet and a low-fat high-carbohydrate diet, for 2years in the gut microbiota of mets patients and those in the control group. we analyzed the differences in the bacterial community structure between the groups after 2years of dietary interven ... | 2016 | 26376027 |
| enhanced butyrate formation by cross-feeding between faecalibacterium prausnitzii and bifidobacterium adolescentis. | cross-feeding is an important metabolic interaction mechanism of bacterial groups inhabiting the human colon and includes features such as the utilization of acetate by butyrate-producing bacteria as may occur between bifidobacterium and faecalibacterium genera. in this study, we assessed the utilization of different carbon sources (glucose, starch, inulin and fructooligosaccharides) by strains of both genera and selected the best suited combinations for evidencing this cross-feeding phenomenon. ... | 2015 | 26420851 |
| faecalibacterium prausnitzii subspecies-level dysbiosis in the human gut microbiome underlying atopic dermatitis. | atopic dermatitis (ad) is a serious global epidemic associated with a modern lifestyle. | 2016 | 26431583 |
| role of the gut microbiome in obesity and diabetes mellitus. | type 2 diabetes mellitus (t2dm) and obesity represent two of the biggest global health challenges of this century and are associated with significant comorbidities and healthcare costs. although multiple factors undoubtedly contribute to the development and progression of dm and obesity, research over the last decade has demonstrated that the microbes that colonize the human gut may play key contributory roles. gut microbes are now known to codevelop with the human host and are strongly influenc ... | 2015 | 26452391 |
| microbiota-specific cd4cd8αα tregs: role in intestinal immune homeostasis and implications for ibd. | in studies in murine models, active suppression by il-10-secreting foxp3 regulatory t cells (tregs) has emerged as an essential mechanism in colon homeostasis. however, the role of the equivalent subset in humans remains unclear, leading to suggestions that other subsets and/or mechanisms may substitute for foxp3 tregs in the maintenance of colon homeostasis. we recently described a new subset of cd4cd8αα t cells reactive to the gut bacterium faecalibacterium prausnitzii and endowed with regulat ... | 2015 | 26500657 |
| two healthy diets modulate gut microbial community improving insulin sensitivity in a human obese population. | gut microbiota, which acts collectively as a fully integrated organ in the host metabolism, can be shaped by long-term dietary interventions after a specific diet. | 2016 | 26505825 |
| real friends: faecalibacterium prausnitzii supports mucosal immune homeostasis. | 2016 | 26531718 | |
| probiotics: a proactive approach to health. a symposium report. | this report summarises talks given at the 8th international yakult symposium, held on 23-24 april 2015 in berlin. two presentations explored different aspects of probiotic intervention: the small intestine as a probiotic target and inclusion of probiotics into integrative approaches to gastroenterology. probiotic recommendations in gastroenterology guidelines and current data on probiotic efficacy in paediatric patients were reviewed. updates were given on probiotic and gut microbiota research i ... | 2015 | 26548336 |
| establishing a causal link between gut microbes, body weight gain and glucose metabolism in humans - towards treatment with probiotics. | changes in the gut microbiota are associated with metabolic disorders, such as overweight and elevated blood glucose. mouse studies have shown that gut microbiota can regulate metabolism with a mechanism related to gut barrier function. an impaired gut barrier permits the translocation of bacteria and their components which, when in contact with the sub-mucosal immune system, evoke metabolic inflammation and distract signalling in metabolically active tissues. despite thorough research of the to ... | 2016 | 26565087 |
| changes in the abundance of faecalibacterium prausnitzii phylogroups i and ii in the intestinal mucosa of inflammatory bowel disease and patients with colorectal cancer. | faecalibacterium prausnitzii comprises 2 phylogroups, whose abundance in healthy and diseased gut and in conjunction with escherichia coli has not yet been studied. this work aims to determine the contribution of f. prausnitzii phylogroups i and ii in intestinal disease and to assess their potential diagnostic usefulness as biomarkers for gut diseases. | 2016 | 26595550 |
| red wine polyphenols modulate fecal microbiota and reduce markers of the metabolic syndrome in obese patients. | this study evaluated the possible prebiotic effect of a moderate intake of red wine polyphenols on the modulation of the gut microbiota composition and the improvement in the risk factors for the metabolic syndrome in obese patients. ten metabolic syndrome patients and ten healthy subjects were included in a randomized, crossover, controlled intervention study. after a washout period, the subjects consumed red wine and de-alcoholized red wine over a 30 day period for each. the dominant bacterial ... | 2016 | 26599039 |
| structural robustness of the gut mucosal microbiota is associated with crohn's disease remission after surgery. | preventing postoperative recurrence after ileocolonic resection (icr) for crohn's disease (cd) is challenging. defining the disturbances of the microbial composition and community structure after icr and their link with early disease recurrence is crucial. | 2016 | 26628508 |
| probiotics and inflammatory bowel diseases. | intestinal microbiota is composed by symbiotic innocuous bacteria and potential pathogens also called pathobionts. even if the mechanism of action of intestinal bacteria remain still unknown, specific microbial species seem to have important role in the maintenance of immunological equilibrium in the gut through the direct interaction with immune cells. some studies have found a dysregulated interaction between the intestinal bacteria, the gut barrier, and the intestinal associated immune system ... | 2017 | 26634595 |
| a simple coculture system shows mutualism between anaerobic faecalibacteria and epithelial caco-2 cells. | most gut bacteria are obligate anaerobes and are important for human health. however, little mechanistic insight is available on the health benefits of specific anaerobic gut bacteria. a main obstacle in generating such knowledge is the lack of simple and robust coculturing methods for anaerobic bacteria and oxygen-requiring human cells. here, we describe the development of a coculture system for intestinal caco-2 cells and an anaerobic symbiont, faecalibacterium prausnitzii, making use of 50 ml ... | 2015 | 26667159 |
| the presence of the anti-inflammatory protein mam, from faecalibacterium prausnitzii, in the intestinal ecosystem. | 2016 | 26669616 | |
| modulation of the gut microbiota composition by rifaximin in non-constipated irritable bowel syndrome patients: a molecular approach. | rifaximin, with its low systemic absorption, may represent a treatment of choice for irritable bowel syndrome (ibs), mainly due to its ability to act on ibs pathogenesis, through the influence on gut microbiota. the aim of the present study was to assess, by biomolecular tools, the rifaximin active modulation exerted on gut microbiota of non-constipated ibs patients. fifteen non-constipated ibs subjects were treated with 550 mg rifaximin three times a day for 14 days. stool samples were collecte ... | 2015 | 26673000 |
| potential association of vacuum cleaning frequency with an altered gut microbiota in pregnant women and their 2-year-old children. | westernized lifestyle and hygienic behavior have contributed to dramatic changes in the human-associated microbiota. this particularly relates to indoor activities such as house cleaning. we therefore investigated the associations between washing and vacuum cleaning frequency and the gut microbiota composition in a large longitudinal cohort of mothers and their children. the gut microbiota composition was determined using 16s ribosomal rna (rrna) gene illumina deep sequencing. | 2015 | 26687338 |
| oral administration of faecalibacterium prausnitzii decreased the incidence of severe diarrhea and related mortality rate and increased weight gain in preweaned dairy heifers. | probiotics are a promising alternative to improve food animal productivity and health. however, scientific evidence that specific microbes can be used to benefit animal health and performance is limited. the objective of this study was to evaluate the effects of administering a live culture of faecalibacterium prausnitzii to newborn dairy calves on subsequent growth, health, and fecal microbiome. initially, a safety trial was conducted using 30 newborn bull calves to assess potential adverse eff ... | 2015 | 26710101 |
| faecalibacterium prausnitzii a2-165 has a high capacity to induce il-10 in human and murine dendritic cells and modulates t cell responses. | faecalibacterium prausnitzii strain a2-165 was previously reported to have anti-inflammatory properties and prevent colitis in a tnbs model. we compared the immunomodulatory properties of strain a2-165 to four different f. prausnitzii isolates and eight abundant intestinal commensals using human dendritic cells (dcs) and mouse bmdcs in vitro. principal component analysis revealed that the cytokine response to f. prausnitzii a2-165 is distinct from the other strains in eliciting high amounts of i ... | 2016 | 26725514 |
| [effects of faecalibacterium prausnitzii supernatant on th17 cell and il-17a in dextran sulfate sodium-induced ulcerative colitis mice]. | to explore the protective and therapeutic effects of faecalibacterium prausnitzii (fp) supernatant on ulcerative colitis (uc) in mice induced by dextran sulfate sodium (dss) and the underlying mechanisms. | 2015 | 26739073 |
| soluble arabinoxylan enhances large intestinal microbial health biomarkers in pigs fed a red meat-containing diet. | the aim of this study was to investigate how moderately increased dietary red meat combined with a soluble fiber (wheat arabinoxylan [ax]) alters the large intestinal microbiota in terms of fermentative end products and microbial community profiles in pigs. | 2016 | 26740253 |
| modulation of the human gut microbiota by dietary fibres occurs at the species level. | dietary intake of specific non-digestible carbohydrates (including prebiotics) is increasingly seen as a highly effective approach for manipulating the composition and activities of the human gut microbiota to benefit health. nevertheless, surprisingly little is known about the global response of the microbial community to particular carbohydrates. recent in vivo dietary studies have demonstrated that the species composition of the human faecal microbiota is influenced by dietary intake. there i ... | 2016 | 26754945 |
| anti-nociceptive effect of faecalibacterium prausnitzii in non-inflammatory ibs-like models. | visceral pain and intestinal dysbiosis are associated with irritable bowel syndrome (ibs), a common functional gastrointestinal disorder without available efficient therapies. in this study, a decrease of faecalibacterium prausnitzii presence has been observed in an ibs-like rodent model induced by a neonatal maternal separation (nms) stress. moreover, it was investigated whether f. prausnitzii may have an impact on colonic sensitivity. the a2-165 reference strain, but not its supernatant, signi ... | 2016 | 26775847 |
| reduced abundance of butyrate-producing bacteria species in the fecal microbial community in crohn's disease. | the global alteration of the gut microbial community (dysbiosis) plays an important role in the pathogenesis of inflammatory bowel diseases (ibds). however, bacterial species that characterize dysbiosis in ibd remain unclear. in this study, we assessed the alteration of the fecal microbiota profile in patients with crohn's disease (cd) using 16s rrna sequencing. | 2016 | 26789999 |
| signatures of early frailty in the gut microbiota. | frailty is arguably the biggest problem associated with population ageing, and associates with gut microbiome composition in elderly and care-dependent individuals. here we characterize frailty associations with the gut microbiota in a younger community dwelling population, to identify targets for intervention to encourage healthy ageing. | 2016 | 26822992 |
| quantitative analysis of intestinal flora of uygur and han ethnic chinese patients with ulcerative colitis. | aim. to study the correlation between intestinal flora and ulcerative colitis by analyzing the abundance of bacteroides, fusobacterium, clostridium, bifidobacterium spp., and faecalibacterium prausnitzii in the intestinal of ulcerative colitis (uc) patients and healthy controls with uygur and han ethnic. methods. bacterial genomic dna was extracted from fecal samples and analyzed with real-time fluorescence quantitative polymerase chain reaction (pcr) to identify the abundance of bacteroides, fu ... | 2016 | 26839545 |
| the colonic microbiome and epithelial transcriptome are altered in rats fed a high-protein diet compared with a normal-protein diet. | a high-protein diet (hpd) can produce hazardous compounds and reduce butyrate-producing bacteria in feces, which may be detrimental to gut health. however, information on whether hpd affects intestinal function is limited. | 2016 | 26843585 |
| oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with ibd. | iron deficiency is a common complication in patients with ibd and oral iron therapy is suggested to exacerbate ibd symptoms. we performed an open-labelled clinical trial to compare the effects of per oral (po) versus intravenous (iv) iron replacement therapy (irt). | 2017 | 26848182 |
| intestinal microbiota distinguish gout patients from healthy humans. | current blood-based approach for gout diagnosis can be of low sensitivity and hysteretic. here via a 68-member cohort of 33 healthy and 35 diseased individuals, we reported that the intestinal microbiota of gout patients are highly distinct from healthy individuals in both organismal and functional structures. in gout, bacteroides caccae and bacteroides xylanisolvens are enriched yet faecalibacterium prausnitzii and bifidobacterium pseudocatenulatum depleted. the established reference microbial ... | 2016 | 26852926 |
| effects of cocoa husk feeding on the composition of swine intestinal microbiota. | a two-diet/two-period change over experiment was performed to investigate the effects of cocoa husks, as a source of dietary fiber and polyphenols, on pig intestinal microbial composition. six pigs were fed a conventional cereal-based diet or a diet obtained by substitution of 7.5% of the conventional diet with cocoa husks for 3 weeks. experimental diets were isoproteic and isoenergetic. at the end of each 3 week testing period, samples of fresh feces were collected and analyzed for microbial co ... | 2016 | 26877143 |
| anti-tnf therapy response in patients with ulcerative colitis is associated with colonic antimicrobial peptide expression and microbiota composition. | anti-tumour necrosis factor [tnf] therapy is used in patients with ulcerative colitis [uc], but not all patients respond to treatment. antimicrobial peptides [amps] and the gut microbiota are essential for gut homeostasis and may be important for treatment outcome. the aim of this study was to determine amp and microbiota profiles in patients with uc before anti-tnf therapy start and correlate these data to treatment outcome. | 2016 | 26896085 |
| relationship of enhanced butyrate production by colonic butyrate-producing bacteria to immunomodulatory effects in normal mice fed an insoluble fraction of brassica rapa l. | this study was performed to determine the effects of feeding a fiber-rich fraction of brassica vegetables on the immune response through changes in enteric bacteria and short-chain fatty acid (scfa) production in normal mice. the boiled-water-insoluble fraction of brassica rapa l. (nozawana), which consists mainly of dietary fiber, was chosen as a test material. a total of 31 male c57bl/6j mice were divided into two groups and housed in a specific-pathogen-free facility. the animals were fed eit ... | 2016 | 26921420 |
| alterations in the mucosa-associated bacterial composition in crohn's disease: a pilot study. | changes in the intestinal bacterial composition seem to play a major role in the pathogenesis and in the clinical course of inflammatory bowel diseases (ibd), which consist of crohn's disease (cd), and ulcerative colitis (uc). mutations in the nod2 gene are the most important genetic risk factors for the development of cd. in this study, the association between mucosal biopsies and the mucosa-associated bacterial composition from cd and uc patients regarding their genetic risk factors (mutations ... | 2016 | 26951181 |
| similar depletion of protective faecalibacterium prausnitzii in psoriasis and inflammatory bowel disease, but not in hidradenitis suppurativa. | psoriasis and hidradenitis suppurativa [hs] co-occur more often with inflammatory bowel disease [ibd] than expected, due to shared pathogenic and genetic features. it is known that ibd patients harbour an altered intestinal microbiome characterised by a depletion of faecalibacterium prausnitzii and increase of escherichia coli. at present, it is unclear whether a similar intestinal microbiome trend can be identified in ibd-associated skin disorders. we therefore investigated the f. prausnitzii a ... | 2016 | 26971052 |
| relative abundance in bacterial and fungal gut microbes in obese children: a case control study. | differences in relative proportions of gut microbial communities in adults have been correlated with intestinal diseases and obesity. in this study we evaluated the gut microbiota biodiversity, both bacterial and fungal, in obese and normal-weight school-aged children. | 2017 | 27007700 |
| correlation between diet and gut bacteria in a population of young adults. | dietary habits strongly influence gut microbiota. the aim of this study was to compare and correlated the abundance of firmicutes and bacteroidetes phyla, some representative bacteria of these phyla such as bacteroides thetaiotaomicron, prevotella, faecalibacterium prausnitzii, clostridium leptum and bifidobacterium longum as a member of actinobacteria phylum in young adults with their food intake. faecal samples used came from lean subjects (bmi = 19.83 ± 0.94 kg/m(2)), overweight (bmi = 27.17 ... | 2016 | 27018166 |
| effect of oligosaccharides on the adhesion of gut bacteria to human ht-29 cells. | the influence of five oligosaccharides (cellobiose, stachyose, raffinose, lactulose and chito-oligosaccharides) on the adhesion of eight gut bacteria (bifidobacterium bifidum atcc 29521, bacteroides thetaiotaomicron atcc 29148d-5, clostridium leptum atcc 29065, blautia coccoides atcc 29236, faecalibacterium prausnitzii atcc 27766, bacteroides fragilis atcc 23745, clostridium difficile atcc 43255 and lactobacillus casei atcc 393) to mucous secreting and non-mucous secreting ht-29 human epithelial ... | 2016 | 27018325 |
| faecalibacterium prausnitzii phylotypes in type two diabetic, obese, and lean control subjects. | faecalibacterium prausnitzii is one of the main butyrate producers in the healthy human gut. information on its genetic diversity is lacking, although two genetic phylotypes have been differentiated. in the present study, f. prausnitzii phylotypes were examined in faeces of obese and type two diabetes with similar eating behaviour compared to a lean control group. the purpose of the study was to analyse if an excessive butyrate production induced by different f. prausnitzii phylotypes discrimina ... | 2016 | 27048834 |
| understanding the impact of omega-3 rich diet on the gut microbiota. | background. recently, the importance of the gut microbiota in the pathogenesis of several disorders has gained clinical interests. among exogenous factors affecting gut microbiome, diet appears to have the largest effect. fatty acids, especially omega-3 polyunsaturated, ameliorate a range of several diseases, including cardiometabolic and inflammatory and cancer. fatty acids associated beneficial effects may be mediated, to an important extent, through changes in gut microbiota composition. we s ... | 2016 | 27065349 |
| faecal metaproteomic analysis reveals a personalized and stable functional microbiome and limited effects of a probiotic intervention in adults. | recent metagenomic studies have demonstrated that the overall functional potential of the intestinal microbiome is rather conserved between healthy individuals. here we assessed the biological processes undertaken in-vivo by microbes and the host in the intestinal tract by conducting a metaproteome analysis from a total of 48 faecal samples of 16 healthy adults participating in a placebo-controlled probiotic intervention trial. half of the subjects received placebo and the other half consumed la ... | 2016 | 27070903 |
| intestinal microbiota and microbial metabolites are changed in a pig model fed a high-fat/low-fiber or a low-fat/high-fiber diet. | the intestinal microbiota and its metabolites appear to be an important factor for gastrointestinal function and health. however, research is still needed to further elaborate potential relationships between nutrition, gut microbiota and host's health by means of a suitable animal model. the present study examined the effect of two different diets on microbial composition and activity by using the pig as a model for humans. eight pigs were equally allotted to two treatments, either fed a low-fat ... | 2016 | 27100182 |
| ruthenibacterium lactatiformans gen. nov., sp. nov., an anaerobic, lactate-producing member of the family ruminococcaceae isolated from human faeces. | two novel strains of gram-stain-negative, rod-shaped, obligately anaerobic, non-spore-forming, non-motile bacteria were isolated from the faeces of healthy human subjects. the strains, designated as 585-1t and 668, were characterized by mesophilic fermentative metabolism, production of d-lactic acid, succinic acid and acetic acid as end products of d-glucose fermentation, prevalence of c18 : 1ω9, c18 : 1ω9 aldehyde, c16 : 0 and c16 : 1ω7c fatty acids, presence of glycine, glutamic acid, lysine, ... | 2016 | 27154556 |
| bifidobacterial inulin-type fructan degradation capacity determines cross-feeding interactions between bifidobacteria and faecalibacterium prausnitzii. | prebiotic inulin-type fructans (itf) display a bifidogenic and butyrogenic effect. four bifidobacterial strains (bifidobacterium breve yakult, bifidobacterium adolescentis lmg 10734, bifidobacterium angulatum lmg 11039(t), and bifidobacterium longum subsp. longum lmg 11047), displaying different itf degradation capacities, were each grown in cocultivation with faecalibacterium prausnitzii dsm 17677(t), an itf-degrading butyrate-producing colon bacterium, as to unravel their cross-feeding interac ... | 2016 | 27233082 |
| intestinal microbiota of broiler chickens as affected by litter management regimens. | poultry litter is a mixture of bedding materials and enteric bacteria excreted by chickens, and it is typically reused for multiple growth cycles in commercial broiler production. thus, bacteria can be transmitted from one growth cycle to the next via litter. however, it remains poorly understood how litter reuse affects development and composition of chicken gut microbiota. in this study, the effect of litter reuse on the microbiota in litter and in chicken gut was investigated using 2 litter m ... | 2016 | 27242676 |
| emerging evidence of the role of gut microbiota in the development of allergic diseases. | the purpose is to review recent studies examining the role of gut microbiota in allergic diseases and asthma. | 2016 | 27253486 |
| mucosa-associated ileal microbiota in new-onset pediatric crohn's disease. | the composition of the intestinal microbiome seems relevant to the pathogenesis of crohn's disease (cd), with differences in both diversity and composition of the gut microbiota in patients with cd compared with healthy individuals. however, there are still conflicting reports on the importance of various bacterial taxa in the pathogenesis of cd. the aim of this study was to characterize the composition of mucosa-associated intestinal microbiota in newly diagnosed pediatric patients with cd. | 2016 | 27271491 |
| the microbiota in pediatric rheumatic disease: epiphenomenon or therapeutic target? | there has been increasing interest in the contents and function of the microbiota, as it relates to pediatric inflammatory diseases. here, we discuss the factors underlying the development of the microbiota, its role in juvenile idiopathic arthritis (jia) and prospects for therapeutic interventions in the microbiota. | 2016 | 27286235 |
| faecalibacterium prausnitzii supernatant ameliorates dextran sulfate sodium induced colitis by regulating th17 cell differentiation. | to explore the preventive and therapeutic effects of faecalibacterium prausnitzii (f. prausnitzii) supernatant on dextran sulfate sodium (dss) induced colitis in mice. | 2016 | 27298563 |
| roux-en-y gastric bypass surgery of morbidly obese patients induces swift and persistent changes of the individual gut microbiota. | roux-en-y gastric bypass (rygb) is an effective means to achieve sustained weight loss for morbidly obese individuals. besides rapid weight reduction, patients achieve major improvements of insulin sensitivity and glucose homeostasis. dysbiosis of gut microbiota has been associated with obesity and some of its co-morbidities, like type 2 diabetes, and major changes of gut microbial communities have been hypothesized to mediate part of the beneficial metabolic effects observed after rygb. here we ... | 2016 | 27306058 |
| could gut microbiota serve as prognostic biomarker associated with colorectal cancer patients' survival? a pilot study on relevant mechanism. | evidences have shown that dysbiosis could promote the progression of colorectal cancer (crc). however, the association of dysbiosis and prognosis of crc is barely investigated. therefore, we used 16s rrna gene sequencing approach to determine differences in microbiota among tumor tissues of different prognosis and found that fusobacterium nucleatum and bacteroides fragilis were more abundant in worse prognosis groups, while faecalibacterium prausnitzii displayed higher abundance in survival grou ... | 2016 | 27323816 |
| nasopharyngeal microbiota composition of children is related to the frequency of upper respiratory infection and acute sinusitis. | upper respiratory infections (uri) and their complications are a major healthcare burden for pediatric populations. although the microbiology of the nasopharynx is an important determinant of the complications of uri, little is known of the nasopharyngeal (np) microbiota of children, the factors that affect its composition, and its precise relationship with uri. | 2016 | 27364497 |
| microbial community of healthy thai vegetarians and non-vegetarians, their core gut microbiota, and pathogen risk. | pyrosequencing analysis of intestinal microflora from healthy thai vegetarians and non-vegetarians exhibited 893 otus covering 189 species. the strong species indicators of vegetarians and non-vegetarians were prevotella copri and bacteroides vulgatus as well as bacteria close to escherichia hermanii with % relative abundance of 16.9 and 4.5-4.7, respectively. core gut microbiota of the vegetarian and non-vegetarian groups consisted of 11 and 20 different bacterial species, respectively, belongi ... | 2016 | 27381339 |
| a reduction in the butyrate producing species roseburia spp. and faecalibacterium prausnitzii is associated with chronic kidney disease progression. | the human gut microbiota plays an important role in human health and might also be implicated in kidney disease. the interest in butyrate producing bacteria has recently increased and is a poorly understood faecal condition in chronic kidney disease (ckd). therefore, we evaluated differences of the butyrate producing species roseburia spp. and faecalibacterium prausnitzii in the faeces of chinese patients with ckd. a case-control study was carried out for 65 ckd patients and 20 healthy controls. ... | 2016 | 27431681 |
| bifidobacteria and butyrate-producing colon bacteria: importance and strategies for their stimulation in the human gut. | with the increasing amount of evidence linking certain disorders of the human body to a disturbed gut microbiota, there is a growing interest for compounds that positively influence its composition and activity through diet. besides the consumption of probiotics to stimulate favorable bacterial communities in the human gastrointestinal tract, prebiotics such as inulin-type fructans (itf) and arabinoxylan-oligosaccharides (axos) can be consumed to increase the number of bifidobacteria in the colo ... | 2016 | 27446020 |
| gut microbiota richness and composition and dietary intake of overweight pregnant women are related to serum zonulin concentration, a marker for intestinal permeability. | increased intestinal permeability may precede adverse metabolic conditions. the extent to which the composition of the gut microbiota and diet contribute to intestinal permeability during pregnancy is unknown. | 2016 | 27466607 |
| comparison of the gut microbial community between obese and lean peoples using 16s gene sequencing in a japanese population. | altered gut microbial ecology contributes to the development of metabolic diseases including obesity. in this study, we performed 16s rrna sequence analysis of the gut microbiota profiles of obese and lean japanese populations. the v3-v4 hypervariable regions of 16s rrna of fecal samples from 10 obese and 10 lean volunteers were sequenced using the illumina miseq(tm)ii system. the average body mass index of the obese and lean group were 38.1 and 16.6 kg/m(2), respectively (p<0.01). the shannon d ... | 2016 | 27499582 |
| age-associated effect of kestose on faecalibacterium prausnitzii and symptoms in the atopic dermatitis infants. | although faecalibacterium prausnitzii is a major bacterium in the intestine of adults, which is known to have anti-inflammatory effects, the development in infants or the response to prebiotics remains unclear. | 2016 | 27537603 |
| gut microbial diversity is reduced in smokers with crohn's disease. | smoking has a negative impact on crohn's disease (cd), but the mechanisms underlying this association are unclear. we compared the gut microbiota composition of smoking with nonsmoking patients with cd using a metagenomic approach. | 2016 | 27542127 |
| gut microbiota associated with hiv infection is significantly enriched in bacteria tolerant to oxygen. | gut microbiota modifications occurring during hiv infection have recently been associated with inflammation and microbial translocation. however, discrepancies between studies justified a comprehensive analysis performed on a large sample size. | 2016 | 27547442 |
| role of intestinal flora imbalance in pathogenesis of pouchitis. | to discuss the role of intestinal flora imbalance in the pathogenesis of pouchitis. | 2016 | 27569889 |
| gut microbiota of obese, type 2 diabetic individuals is enriched in faecalibacterium prausnitzii, akkermansia muciniphila and peptostreptococcus anaerobius after weight loss. | beside the influence of nutritional habits and reduced physical activity, metabolic syndrome is associated with alterations in the structure of gut microbiota influencing the inflammatory immune responses. gut microbiota and microbial metabolic activities are known to affect the lipid and glucose metabolism, satiety and chronic low-grade inflammation in the metabolic syndrome. the aim of the study was to identify genera or even species affecting host metabolism in obesity and type 2 diabetes bes ... | 2016 | 27577947 |
| the association between the gut microbiota and the inflammatory bowel disease activity: a systematic review and meta-analysis. | the pathogenesis of inflammatory bowel diseases (ibd) involves complex interactions between the microbiome and the immune system. we evaluated the association between the gut microbiota and disease activity in ibd patients. | 2016 | 27687331 |
| gut microbiota related to giardia duodenalis, entamoeba spp. and blastocystis hominis infections in humans from côte d'ivoire. | literature data provide little information about protozoa infections and gut microbiota compositional shifts in humans. this preliminary study aimed to describe the fecal bacterial community composition of people from côte d'ivoire harboring giardia duodenalis, entamoeba spp., and blastocystis hominis, in trying to discover possible alterations in their fecal microbiota structure related to the presence of such parasites. | 2016 | 27694739 |
| unique features of ethnic mongolian gut microbiome revealed by metagenomic analysis. | the human gut microbiota varies considerably among world populations due to a variety of factors including genetic background, diet, cultural habits and socioeconomic status. here we characterized 110 healthy mongolian adults gut microbiota by shotgun metagenomic sequencing and compared the intestinal microbiome among mongolians, the hans and european cohorts. the results showed that the taxonomic profile of intestinal microbiome among cohorts revealed the actinobaceria and bifidobacterium were ... | 2016 | 27708392 |
| assessment of the prebiotic effect of quinoa and amaranth in the human intestinal ecosystem. | quinoa and amaranth belong to the group of the so called "superfoods" and have a nutritional composition that confers multiple benefits. in this work, we explored the possibility of these foods exhibiting a prebiotic effect. these pseudocereals were subjected to an in vitro digestion and used as carbon sources in batch cultures with faecal human inocula. the effects on the microbiota composition and their metabolic products were determined by assessment of variations in ph, short-chain fatty aci ... | 2016 | 27713989 |
| effects of varying dietary content of fermentable short-chain carbohydrates on symptoms, fecal microenvironment, and cytokine profiles in patients with irritable bowel syndrome. | a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (fodmaps) is increasingly recommended for patients with irritable bowel syndrome (ibs). we aimed to investigate the effects of a blinded low-fodmap vs high-fructo-oligosaccharides (fos) diet on symptoms, immune activation, gut microbiota composition, and short-chain fatty acids (scfas). | 2017 | 27747984 |
| comparative genomics of clostridium bolteae and clostridium clostridioforme reveals species-specific genomic properties and numerous putative antibiotic resistance determinants. | clostridium bolteae and clostridium clostridioforme, previously included in the complex c. clostridioforme in the group clostridium xiva, remain difficult to distinguish by phenotypic methods. these bacteria, prevailing in the human intestinal microbiota, are opportunistic pathogens with various drug susceptibility patterns. in order to better characterize the two species and to obtain information on their antibiotic resistance genes, we analyzed the genomes of six strains of c. bolteae and six ... | 2016 | 27769168 |
| association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly. | the pathway leading from amyloid-β deposition to cognitive impairment is believed to be a cornerstone of the pathogenesis of alzheimer's disease (ad). however, what drives amyloid buildup in sporadic nongenetic cases of ad is still unknown. ad brains feature an inflammatory reaction around amyloid plaques, and a specific subset of the gut microbiota (gmb) may promote brain inflammation. we investigated the possible role of the gmb in ad pathogenesis by studying the association of brain amyloidos ... | 2017 | 27776263 |
| sialoglycoprotein isolated from the eggs of carassius auratus prevents bone loss: an effect associated with the regulation of gut microbiota in ovariectomized rats. | the anti-osteoporotic effect of sialoglycoprotein isolated from the eggs of carassius auratus (ca-sgp) has previously been demonstrated in vivo. however, the mechanism by which this macromolecular substance regulates bone metabolism remains unclear. given the correlation between gut microbiota and the homeostasis of bone metabolism, the current study applied real-time pcr and 16s rrna high-throughput sequencing to investigate the influence of ca-sgp on gut microbiota in ovariectomized rats. real ... | 2016 | 27808338 |