Publications

expression of human papillomavirus proteins in yeast saccharomyces cerevisiae.	the l1 and l2 proteins of human papillomavirus (hpv) types 1, 6, and 16 and the e6 and e7 proteins of hpv 16 were expressed in saccharomyces cerevisiae. the yeast expressed proteins were readily detected by immune blotting and were generally intact. the hpv 1 l1 and l2 proteins expressed in yeast were indistinguishable from the major and minor capsid proteins purified from hpv 1 virions as judged by gel electrophoresis and immunoblotting. the hpv 6 and hpv 16 l2 proteins and hpv 16 e7 proteins w ...	1991	1850917
regulation of alcohol consumption by the renin-angiotensin system: a review of recent findings and a possible mechanism of action.	the renin-angiotensin system has traditionally been associated with the regulation of fluid and electrolyte balance. in this review we summarize the data which ascribes a completely new function to this system, i.e., the regulation of alcohol consumption. in addition, we suggest a possible mechanism for this effect based on the concept of a satiety or stop process. the approach taken was to examine the effect on alcohol intake of a wide variety of drug, genetic, dietary, surgical and neurosurgic ...	2007	1852316
response by dr. alden n. haffner upon receipt of the koch memorial medal 1990.		2007	1852404
[anti-endotoxin monoclonal antibodies in the treatment of gram-negative germ sepsis].		2007	1853112
comparison of live avirulent m-9, minnesota, and cu fowl cholera vaccines.	the m-9 and minnesota (mn) avirulent pasteurella multocida vaccines were evaluated and compared with the clemson university (cu) vaccine, which had been shown to be highly effective in preventing fowl cholera in turkeys. neither the m-9 nor the mn vaccine given in the drinking water was as effective as the cu vaccine in protecting turkeys against challenge with virulent p. multocida. when grown in brain-heart infusion (bhi) agar as recommended, the m-9 was not as efficacious as when it was grown ...	1991	1854311
in vivo antigen expression by pasteurella multocida.	pasteurella multocida was purified from the blood of turkeys affected with acute fowl cholera, and membrane preparations from those bacteria were separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and visualized on immunoblots. antigens were detected in the membranes of these in vivo-propagated bacteria that were not detected in membrane preparations of the same p. multocida strain grown in vitro. the unique antigens were detected in the detergent-insoluble phase and were enr ...	1991	1854322
pasteurella multocida peritonitis in capd: beware of the cats.		1991	1854879
quantitative study of striate single unit responses in monkeys performing an orientation discrimination task.	contour orientation discrimination accuracy is determined by the orientation bandwidth, response variance and response strength of single units that code for orientation. we measured the latter three properties for v1 cells of monkeys which were performing an orientation discrimination of the grating stimulating the cell under study. we recorded from 285 cells, of which 76% responded to the grating. the orientation bandwidth, measured as full width at half height of the tuning curve, varied over ...	1991	1855551
[new osmotic additives to culture media for corneal preservation].	we investigated the effect of hyaluronic acid, molecular weight 250,000 and 500,000 as an osmotic additive to corneal preservation media. porcine corneal specimens were incubated in organ culture for 8 days, followed by endothelial cell count and ultrasonic pachymetry. the preservation medium mem-earle with 2% fcs contained either no additives, 6% dextrane, mw 500,000 2% chondroitin sulfate, 1% hyaluronic acid mw 250,000, or 1% hyaluronic acid, mw 500,000. whereas corneal thickness was estimated ...	1991	1855724
[new osmotic additives to culture media for corneal preservation].	we investigated the effect of hyaluronic acid, molecular weight 250,000 and 500,000 as an osmotic additive to corneal preservation media. porcine corneal specimens were incubated in organ culture for 8 days, followed by endothelial cell count and ultrasonic pachymetry. the preservation medium mem-earle with 2% fcs contained either no additives, 6% dextrane, mw 500,000 2% chondroitin sulfate, 1% hyaluronic acid mw 250,000, or 1% hyaluronic acid, mw 500,000. whereas corneal thickness was estimated ...	1991	1855724
enhanced interstitial fluid adenosine attenuates myocardial stunning.	reversible myocardial dysfunction associated with transient ischemia has been termed the stunned myocardium. because exogenous adenosine has been shown to protect the ischemic myocardium, we hypothesized that augmentation of endogenous adenosine levels would attenuate myocardial stunning. to induce stunning, anesthetized dogs were subjected to 15 minutes of ischemia (left anterior descending artery occlusion) followed by 60 minutes of reperfusion. erythro-9-(2-hydroxy-3-nonyl) adenine (ehna; 5 m ...	1991	1858025
ultrastructural localization of the pasteurella multocida toxin in a toxin-producing strain.	toxigenic strains of pasteurella multocida produce the 147 kda protein pasteurella multocida toxin (pmt) which is responsible for the osteoclastic bone resorption in progressive atrophic rhinitis in pigs and induces such resorption in all experimental animals tested so far. in the present study we have carried out immunocytochemistry on formaldehyde- and glutaraldehyde-fixed ultracryocut p. multocida using a pool of monoclonal antibodies against different epitopes on pmt as the first layer and a ...	1991	1865180
thyroid crisis associated with severe hypocalcemia.	a 30-year-old woman with thyroid crisis and impaired renal function presented with severe hypocalcemia. she had already had hypocalcemia one yr previously when her serum creatinine level was normal. a normal level of serum amino terminal fragment of parathyroid hormone in spite of severe hypocalcemia suggested impairment of parathyroid function. since her serum magnesium was normal and she had no history of neck surgery or radioiodine therapy, her hypoparathyroidism was considered to be idiopath ...	2007	1865592
two cases of fetal akinesia/hypokinesia sequence.	two cases of fetal akinesia sequence are described. both showed facial anomalies, arthrogryposis multiplex, bilateral camptodactyly, and pulmonary hypoplasia. one child had degeneration of large motor neurons of the thoracolumbosacral spinal cord and irregular atrophy of diaphragm; the other had left microphthalmia, hemiatrophy of the left temporal lobe with calcification of degenerated neurons, and hypoplasia of the cervothoracic spinal cord with decrease and degeneration of neurons. the iliops ...	2002	1866365
pasteurella multocida: zoonotic cause of peritonitis in a patient undergoing peritoneal dialysis.		1991	1867248
pasteurella multocida infection in a patient with aids.		1991	1870343
meningitis from canine pasteurella multocida following mastoidectomy.	a case of pasteurella multocida meningitis, following a mastoidectomy is presented. the association of close contact with pets, many of which harbour pasteurella multocida as part of their normal buccal flora. this case confirms the potential benefit of taking an ear swab prior to mastoid surgery and in seeking an appropriate 'pet' history.	1991	1875142
high risk of squamous cell carcinoma of the cervix for women with hla-dqw3.	many immune responses are controlled by genes of the major histocompatibility complex (mhc). in man these include the loci encoding the hla-a, -b, -c, -dr, -dq and -dp antigens, and many diseases have been linked with these. but attempts to identify hla genes in man that might explain why an immune response against malignant tumours should be ineffective have so far been disappointing, apart from the association reported between the hla-dr1 antigen and a susceptibility to a rare carcinoma of the ...	1991	1876187
acetylcholinesterase from schistosoma mansoni: immunological characterization.	the enzyme acetylcholinesterase (ache) is present in the trematode schistosoma mansoni, which infects humans and causes a severe disease called schistosomiasis or bilharzia. we have purified this enzyme and raised polyclonal antibodies against it. the specificity of these antibodies against the schistosome enzyme was demonstrated by their capacity to precipitate exclusively ache activity from cercariae extract and to recognize the 8s molecular form of the parasite's ache. on the other hand, they ...	1991	1885212
the protein sequence responsible for lipoprotein membrane localization in escherichia coli exhibits remarkable specificity.	structural information defining an n-terminal sequence required for the membrane sorting of bacterial lipoproteins has been previously garnered through the study of a hybrid outer membrane (om) lipo-beta-lactamase (ll) (ghrayeb and inouye (1984) j. biol. chem. 259, 463-467). introduction of an aspartate as the second residue of mature ll (d2 mutant) causes an inner membrane (im) localization of this protein (yamaguchi, k., yu, f., and inouye, m. (1988) cell 53, 423-432). introduction of as aspar ...	1991	1885579
detection and enumeration of toxin-producing pasteurella multocida with a colony-blot assay.	colonies of toxin-producing pasteurella multocida were detected with peroxidase-labeled monoclonal antibodies by a membrane assay. examination of the specificity of the assay with 29 p. multocida cultures representing various geographic origins, hosts, and serotypes indicated that the test was specific for toxin-producing strains. no cross-reactions were observed with bordetella species that can be associated with p. multocida in producing diseases in animals. a single membrane could be used to ...	1991	1885729
pasteurella haemolytica endocarditis.	although human infections with bacteraemia due to pasteurella multocida are not uncommon, endocarditis associated with p. haemolytica is rare. we describe such a case in which the patient died despite treatment with apparently appropriate antimicrobial agents.	1991	1885915
relationship between the iron regulated outer membrane proteins and the outer membrane proteins of in vivo grown pasteurella multocida.	the sds-page patterns of the outer membrane protein (omp) extracts of pasteurella multocida strain p1059, grown under iron-restricted, iron-replete and in vivo conditions, were examined. the results showed that the iron-regulated outer membrane proteins (iromps) with molecular masses of 76 kda, 84 kda, and 94 kda were expressed by bacteria grown in iron-restricted media. they were also expressed by in vivo grown p. multocida. convalescent-phase sera, obtained from turkeys which had survived past ...	1991	1887567
toxigenic pasteurella multocida in rabbits with naturally occurring atrophic rhinitis.	in a commercial rabbitry nasal swabs were taken from 36 animals with enzootic upper respiratory disease resembling porcine atrophic rhinitis. 35 pasteurella multocida strains were isolated from 17 rabbits. among 30 strains tested for dermonecrotic toxin production 3, derived from 3 animals, were positive in the guinea pig skin test. 15 bordetella bronchiseptica strains were recovered from 14 rabbits. no toxigenic strains were found among 6 isolates tested using the same method.	1991	1887698
pasteurella multocida septicaemia in fallow deer (dama dama).	thirteen of 100 fallow deer, aged between 6 months and 10 years, died over a 5 week period. the deaths occurred in 2 outbreaks 3 weeks apart. both outbreaks were preceded by at least 3 days of cold wet and windy weather, and were associated with water-logged pastures. affected animals were usually found dead, with a frothy blood-stained nasal discharge. in the 8 deer necropsied, gross lesions included widespread subserosal petechial haemorrhages, severe pulmonary congestion and oedema with froth ...	1991	1888312
pet in generalized anxiety disorder.	positron emission tomography (pet) measurements of cerebral glucose use were made in 18 patients with generalized anxiety disorder (gad) during a passive viewing task off medication, and an active vigilance viewing task before and after medication or placebo treatment. in the passive viewing task, patients with gad were compared with 15 normal controls. a significant difference in pattern of absolute brain metabolism was found. patients showed lower absolute metabolic rates in basal ganglia and ...	2007	1888800
atrophic rhinitis caused by pasteurella multocida type d: morphometric analysis.	in order to study the distribution and the extent of atrophy caused by pasteurella multocida in the nasal conchae, experimental piglets were injected intramuscularly at seven days of age with either two or four 50% mouse lethal doses per kg body weight of p. multocida type d dermonecrotoxin. experimental and control piglets were killed four, six and ten days postinjection. serial transverse paraffin embedded sections of the noses were cut throughout the entire length of the nasal conchae. the ar ...	1991	1889032
naturally acquired pasteurella multocida infection in rabbits: clinicopathological aspects.	a cohort of 41 new zealand white rabbits, 35 to 60 days old, from twelve litters were followed for twelve weeks for development of pasteurellosis. eleven of 19 rabbits in five litters acquired pasteurella multocida infection. the incubation period was difficult to determine as p. multocida infection was detected both before and after the onset of rhinitis. the response of rabbits to infection varied from subclinical infection to death from systemic pasteurellosis. atrophy of the maxilloturbinate ...	1991	1889034
the xenopus yb3 protein binds the b box element of the class iii promoter.	we have isolated a xenopus cdna encoding the yb3 protein which binds specifically to the b box promoter element of class iii genes. northern analysis shows yb3 is expressed in a variety of adult tissues. fractionation of oocyte s150 extracts demonstrates yb3 is present in phosphocellulose fraction iiic, as well as in the fraction isolated by b box dna affinity chromatography. silver staining indicates that yb3, or a protein of the same mobility in sds gels, is the most abundant component in eith ...	2007	1891365
in vitro antimicrobial susceptibility of pasteurella haemolytica and pasteurella multocida recovered from cattle with bovine respiratory disease complex.	the antimicrobial susceptibilities of 421 pasteurella haemolytica and 158 p. multocida isolates recovered from cattle with respiratory disease were determined with a microdilution minimal inhibitory concentration test system. isolates were analyzed for patterns of resistance to ampicillin, ceftiofur, erythromycin, gentamicin, penicillin, spectinomycin, sulfachlorpyridazine, sulfadimethoxine, tetracycline, and tylosin. all isolates tested were found susceptible to ceftiofur and sulfachlorpyridazi ...	1991	1892929
experimental model of atrophic rhinitis in gnotobiotic pigs.	to study the pathogenesis of atrophic rhinitis, gnotobiotic pigs (n = 6) were inoculated intranasally with a sterile sonicate of a toxigenic strain of bordetella bronchiseptica (0.16 mg of protein per ml) at 5 days of age, and they were then inoculated intranasally with 1 ml (5,250 cfu/ml) of a live, toxigenic strain of pasteurella multocida at 7 days of age. pigs were necropsied at 2, 5, 9, 14, 21, and 28 days postinoculation; those pigs necropsied after 5 days had developed turbinate atrophy. ...	1991	1894365
adherence of pasteurella multocida isolated from pigs and relationship with capsular type and dermonecrotic toxin production.	pasteurella multocida can often be isolated from pneumonic lungs in pigs. there is little information about the pathogenesis of this infection. attachment of microorganisms to eucaryotic cells is considered to be a prerequisite for colonization of the host in the pathogenesis of bacterial infections. forty-seven p multocida strains isolated from pigs in france, and belonging to capsular type a or d were tested for their ability to agglutinate human erythrocytes, and to adhere to tracheal and lun ...	1991	1897871
statistical evidence for a link between bronchopneumonia and disseminated focal nephritis in pigs.	an investigation on the occurrence of different pneumonia types and their possible concurrence with other pluck organ disorders was made on 6,565 pigs presented at slaughter. the frequency of disseminated focal nephritis in a bronchopneumonia group and a non-bronchopneumonia residual group, respectively, was found to differ significantly from the mean frequency of nephritis in all pig plucks examined. the number of lesioned kidneys in each of 28 samples contributing to the bronchopneumonia group ...	1991	1907788
haemorrhagic septicaemia: correlation of vaccinal antibody responses in mice with protection against pasteurella multocida strain m1404.	this study examined the protection induced by oil adjuvant vaccine and broth bacterin in mice. protective immunity was induced by both oil adjuvant and bacterin vaccination procedures. oil adjuvant vaccination induced a 10(5)-fold increase for lethal challenge over control mice, while secondary vaccination induced a further 10-fold increase in resistance to lethal challenge. broth bacterin induced a slightly weaker protective response with 10(4)- and 10(5)-fold increases in resistance to lethal ...	1991	1909067
elective oral tracheal intubation in cervical spine-injured adults.	there is controversy regarding the optimal mode of elective tracheal intubation in the patient with an unstable cervical spine following trauma. a ten-year review of 150 patients with traumatic cervical spine injuries with well-preserved neurological function, presenting for operative stabilization, was conducted to compare neurological outcome with the mode of tracheal intubation. preoperative neurological deficits were identified in 49 patients (33%); most were single-level radiculopathies. in ...	2007	1914066
coronary vasospasm as a potential cause of myocardial infarction and paroxysmal atrial fibrillation in a relatively young woman.	vasospasm-related myocardial infarction in young women with normal coronary arteries has infrequently been reported and vasospasm-related paroxysmal atrial fibrillation (paf) has rarely been described. we present a 33-year-old woman with old inferior myocardial infarction and postinfarction angina at rest; the angina was accompanied by paf and electrocardiographic st-segment elevation in the inferior leads. coronary angiography revealed normal coronary arteries and intracoronary acetylcholine pr ...	2007	1914277
the effect of extraarticular varus and valgus deformity on total knee arthroplasty.	because of trauma, metabolic bone disease, congenital deformity, or prior osteotomy, an extraarticular deformity may be present in patients requiring total knee arthroplasty. if the extraarticular deformity is not corrected extraarticularly, it must be corrected by compensatory distal femoral or proximal tibial wedge resection to produce overall limb alignment. because such a wedge resection between the proximal and distal attachments of the collateral ligaments will produce asymmetrical ligamen ...	2007	1914313
[anticardiolipin antibody in cerebral infarction].	we investigated the anticardiolipin antibody (aca) in a series of patients with cerebral infarction without systemic lupus erythematosus (sla). clinical and laboratory data were assessed from a series of 250 non-sle patients with cerebral infarction who visited our clinic from 1988 to 1990. the concentration of anticardiolipin igg antibody was measured by an enzyme-linked immunosorbent assay technique. an elevated aca level was defined as one which was greater than 3 standard deviations above th ...	2007	1914323
structural and functional relationships between pasteurella multocida and enterobacterial adenylate cyclases.	the pasteurella multocida adenylate cyclase gene has been cloned and expressed in escherichia coli. the primary structure of the protein (838 amino acids) deduced from the corresponding nucleotide sequence was compared with that of e. coli. the two enzymes have similar molecular sizes and, based on sequence conservation at the protein level, are likely to be organized in two functional domains: the amino-terminal catalytic domain and the carboxy-terminal regulatory domain. it was shown that p. m ...	1991	1917858
epizootiology of avian cholera in wildfowl.	pasteurella multocida, the cause of avian cholera, has naturally infected over 100 species of free-living birds. among wild birds, avian cholera has its greatest impact on north american wildfowl. epizootics usually are explosive in onset and may involve thousands of birds. the disease has been reported in every month of the year among wildfowl. disproportionate mortality, with some species suffering proportionately greater mortality than others, has been a common feature of this disease. presen ...	1991	1920657
stability of pathogenic bacteria from laboratory animals in various transport media.	the stability of pathogenic bacteria from laboratory animals was investigated in various transport media at different temperatures. bordetella bronchiseptica and salmonella typhimurium survived for 8 days in phosphate-buffered saline (pbs, ph 7.0) at 37, 24, 4 and -20 degrees c; brucella canis at 24, 4 and -20 degrees c; corynebacterium kutscheri at 4 and -20 degrees c; and pseudomonas aeruginosa at all but -20 degrees c. a marked decrease in numbers of pasteurella multocida and past. pneumotrop ...	1991	1921320
naturally acquired pasteurella multocida subsp. multocida infection in a closed colony of rabbits: characteristics of isolates.	twelve litters, comprising 41 rabbits aged 35 to 60 days old, in a closed university colony, were monitored for acquisition of nasal pasteurella multocida subsp. multocida infection. isolates from 11 infected rabbits were characterized by colonial morphology, capsular type, biotype and antibiotic resistance. selected isolates were further characterized by somatic antigen typing. two major strains of p. multocida subsp. multocida were detected in the colony. one strain had mucoid colonies, fermen ...	1991	1921322
female hiv alert.		1991	1923066
the effect of caffeine on postprandial blood pressure in the frail elderly.	in a double-blind, random-order, cross-over study the effects of placebo and 100 mg of caffeine on postprandial sitting and erect blood pressure and heart rate were studied in 20 frail elderly subjects (mean age 84, range 75-93 years) after a standardized 400 k-calorie glucose drink. maximal postprandial reduction in sitting systolic blood pressure occurred, at 60 minutes post-placebo, of - 11 mmhg (95% confidence interval -5 to -17 mmhg, p less than 0.01), and was attenuated by caffeine (p less ...	2007	1924023
renal damage in mice after sequential cisplatin and irradiation: the influence of prior irradiation on platinum elimination.	doses of 4-6 mg kg-1 c-ddp given 6 months before renal irradiation caused only a modest increase in functional radiation damage (def 1.1). these effects could be explained by additive toxicities and the damage was much less than when c-ddp was given 3-6 months after irradiation. pharmacokinetic studies did not demonstrate any decrease in the rate of platinum elimination after previous low-dose renal irradiation.	2007	1924867
characterization of toxin from different strains of pasteurella multocida serotype a and d.	chromosomal dna from 13 different selected pasteurella multocida spp. multocida strains of serotypes a and d were isolated and compared. all 10 toxigenic strains were recognized by a dna probe which included the toxa gene coding for the pasteurella multocida toxin (pmt). none of the three nontoxigenic strains reacted with the dna probe. toxin from the 10 toxigenic strains were isolated and compared. all were found to possess the biological characteristics previously described for the pmt isolate ...	1991	1927149
molecular distribution of rob-1 beta-lactamase in actinobacillus pleuropneumoniae.	the plasmid content and molecular distribution of the rob-1 beta-lactamase was investigated in 31 swine isolates of actinobacillus pleuropneumoniae. three types of plasmid patterns were observed in ampicillin-resistant isolates: a predominant one consisting of 2.6-, 2.9-, and 5.0-kb plasmids and two other patterns consisting of 4.2- and 5.5-kb plasmids and of a 6.8-kb plasmid. plasmid dna preparations were hybridized with a blarob-1 intragenic fragment from the haemophilus influenzae rrob plasmi ...	1991	1929299
resistance to restriction digestion by plasmids prepared with a lithium-containing lysis buffer.		1971	1931031
[the oculomotor system--simulation of physiologic and pathologic horizontal saccadic eye movements].	horizontal saccadic eye movements were analyzed by way of the input- and output-functions of the oculomotor system. on the basis of the parameters of the model, it was possible to simulate both physiological and pathological saccades. in this paper we present the results of simulation experiments that were performed to study the influence of various ocular motor disorders. the parameters of the model proved a useful diagnostic aid.	2007	1932534
thrombocytosis and ischaemic complications in giant cell arteritis.		2007	1932974
advances in cell kinetics.		2007	1932989
[detection of neutralizing antibodies against pasteurella multocida toxin in swine with atrophic rhinitis].	blood sera of 1171 pigs, not vaccinated against par, were tested for antibodies against p. multocida toxin in a neutralization test with ebl cell cultures. 277 sera were from 18 herds with clinical par; 104 of them (37.5%) had neutralizing antibody titres from 1:2 to 1:1024. no antitoxin was detected in the sera of 866 pigs in 25 par nonsuspicious herds. in one nonsuspicious herd, however, 11 of 28 sera were neutralizing in the 1:2 or 1:4 dilution. 30 sows had been vaccinated with inactivated to ...	1991	1935682
pasteurella multocida and female genital carcinoma; a case report to dispute the concept of genital opportunistic pathogen.		1991	1936508
the outer membrane of pasteurella multocida 3:a protects rabbits against homologous challenge.	the protective efficacy of a vaccine purified from the pasteurella multocida 3:a outer membrane (om) was evaluated in rabbits by homologous challenge. twenty-seven rabbits were divided into four groups: 1, vaccinated with om and challenged; 2, nonvaccinated and challenged; 3, vaccinated with om only; and 4, nonvaccinated and not challenged. rabbits were immunized intranasally with 1 mg of om protein on days 0, 7, 14, and 35, challenged intranasally on day 49, and killed on day 63. mortality rate ...	1991	1937811
architectonics of the parietal and temporal association cortex in the strepsirhine primate galago compared to the anthropoid primate macaca.	a number of higher order association areas have been described in the parietal and temporal cortex of large-brained anthropoid primates such as macaca. however, little is known about the evolution of these areas, and the existence of homologous areas has not yet been clearly demonstrated in other mammalian groups. we addressed this issue by comparing the myelo- and cytoarchitecture of posterior association cortex in the anthropoid macaca to that of the small-brained, strepsirhine ("prosimian") p ...	2007	1939733
effect of cooling rate on the survival of frozen wood frogs, rana sylvatica.	wood frogs (rana sylvatica) were frozen to -2.5 degrees c under five distinct cooling regimes to investigate the effect of cooling rate on survival. frogs survived freezing when cooled at -0.16 degrees c.h-1 or -0.18 degrees c.h-1, but mortality resulted at higher rates (-0.30 degrees c.h-1, -1.03 degrees c.h-1, and -1.17 degrees c.h-1). surviving frogs in the latter groups required longer periods to recover, and transient injury to the neuromuscular system was evident. some of the frogs that di ...	2007	1939737
infections and antibiotic use in a community hospital, 1971-1990.	to determine the prevalence of infections and antibiotic use at a community hospital in 1990 and to compare the results with those from previous surveys in 1971, 1979, and 1984.	2007	1940275
[creatinine clearance as the foundation for clinical determination of kidney function in swine].	comparative examinations of renal function using inulin- and endogenous creatinine-clearance tests in 5 pigs showed nearly identical values of glomerular filtration rate (gfr). based on this relation 79 healthy pigs, weighting 2 kg to 230 kg were investigated using the creatinine-clearance test for determination of normal values of gfr and urine flow rate (vu) as well as renal excretion (e), renal clearance (clr) and fractional excretion (fe) of urea, sodium, potassium, calcium, phosphorus, gluc ...	1991	1948984
colonization of the pharyngeal tonsil and respiratory tract of the gnotobiotic pig by a toxigenic strain of pasteurella multocida type d.	seven-day-old gnotobiotic pigs were inoculated intranasally with pasteurella multocida and euthanatized 2, 5, 9, and 14 days after inoculation. tissues from the oropharynx and respiratory tract of pigs were cultured quantitatively and analyzed microscopically. pigs remained afebrile and alert, except one that died of acute fibrinopurulent pneumonia. pasteurella multocida was isolated in greatest numbers from the pharyngeal tonsils, but only in low numbers from turbinate, trachea, lung, spleen, a ...	1991	1949505
an abattoir survey of pneumonia and pleuritis in slaughter weight swine from 9 selected herds. ii. enzootic pneumonia of pigs: microbiological findings and their relationship to pathomorphology.	lungs from 191 slaughter pigs with gross lesions indicative of enzootic pneumonia of pigs (epp) and 80 grossly normal lungs, all originating from 9 different herds, were subjected to microbiological and pathological examinations. the microbiological studies included both bacterial and mycoplasmal culture and also testing for mycoplasma hyopneumoniae antigen in tissue by indirect immunofluorescent technique. m. hyopneumoniae, pasteurella multocida and mycoplasma hyorhinis were detected in 83%, 43 ...	1991	1950853
clinical and anatomic observations in patients having mitral valve replacement for mitral stenosis and simultaneous tricuspid valve replacement.	certain clinical and morphologic findings are described in 67 patients (aged 23 to 76 years [mean 52]; 55 women [82%]) who had mitral valve replacement for mitral stenosis (with or without associated regurgitation), and simultaneous tricuspid valve replacement for pure tricuspid regurgitation (58 patients) or tricuspid stenosis (all with associated regurgitation; 9 patients). of the 58 patients with pure tricuspid regurgitation, 21 had anatomically normal and 37 had anatomically abnormal (diffus ...	2007	1951127
99mtc-medronate uptake in the temporomandibular joints of young rats treated with a mandibular hyperpropulsor.	to correct maxillomandibular sagittal discrepancies in growing children, most functional appliances position the mandible more anteriorly than its habitual relation with the maxilla. the aim of this study was to evaluate the effects of such a procedure on the mineralization of the temporomandibular joints in young growing rats. temporomandibular joint uptake of a radioactive bone marker, technetium 99m methylene diphosphonate (99mtc-mdp), was measured over time as a hyperpropulsor appliance was ...	1991	1951199
the natural history of abdominal aortic aneurysms.	this study examines the rate of expansion of abdominal aortic aneurysms and the risk of rupture in relation to their size. to assess these variables, we conducted a prospective study of 300 consecutive patients who presented over a 6-year interval with abdominal aortic aneurysms (aaa) that were initially managed nonoperatively. the mean age of the patients was 70.4 years, and 211 (70%) were men. the mean initial aneurysm diameter was 4.1 cm. among the 208 patients who underwent more than one ult ...	2007	1951914
leaking t-connector in toptronic oxygen analyser.		2007	1952014
resistance of pasteurella multocida a:3,4 to phagocytosis by turkey macrophages and heterophils.	a virulent field isolate and 2 vaccine strains of pasteurella multocida a:3,4 were compared for resistance to phagocytosis by turkey macrophages and heterophils, using in vitro assays. the least virulent vaccine strain (m-9) was phagocytosed to a greater degree than was the field isolate or the other vaccine strain (clemson university). all 3 bacteria differed significantly from each other in the amount of capsular material present as measured by polycationic ferritin labeling and electron micro ...	1991	1952342
pasteurellosis in bobwhite quail.	a flock of 5000 six-week-old bobwhite quails (colinus virginianus) experienced high mortality (52%) over a 2-day period. mortality was 99% within a 6-day period. clinical signs were depression followed shortly by death. gross lesions observed in dead quails were congested lungs and, in a few cases, mottled livers. histopathologic examination revealed severe, diffuse, heterophilic interstitial pneumonia and multifocal areas of hepatic and splenic necrosis with numerous intracellular and extracell ...	1991	1953585
[pasteurella multocida as the cause of disease outbreaks in commercial poultry flocks].	six cases of fowl cholera in growing turkeys and 3 in adult breeder chickens of the broiler type as well as one case each of a pasteurella (p.) multocida-associated disease in ducklings and goslings were described in consideration of own laboratory findings and available informations of the case history. furthermore a report is given on a treatment strategy successfully used in turkeys with highly acute fowl cholera. all the p. multocida strains isolated culturally could be assigned to the subsp ...	1991	1953629
infections resulting from animal bites.	animal bites are a major public health problem. this article reviews the epidemiology and treatment of animal bites. the epidemiology, clinical presentation, and treatment of infections caused by pasteurella multocida and capnocytophaga canimorsus (df-2) are reviewed in detail.	1991	1955705
estimates of quantitative genetic parameters of immunological traits in the chicken.	three in vivo assays were used to measure the immunocompetence of chickens in two generations of a selection experiment. the obtained data were used to estimate the variance components for sire and dam for antibody production to pasteurella multocida and mycoplasma gallisepticum vaccines, for t-cell-mediated immunity evaluated by a phytohemagglutinin wing web assay, and for clearance of foreign particles from the circulatory system. heritabilities of and genetic correlations among these immunolo ...	1991	1956847
immunisation of cattle and buffaloes with live haemorrhagic septicaemia vaccine.		1991	1957476
evaluation of combined pasteurella vaccines in control of sheep pneumonia.	the effectiveness of an oil adjuvant vaccine (oav) incorporating locally isolated strains of pasteurella haemolytica type 7 and pasteurella multocida types a and d was compared with that of carovax (wellcome laboratories) in imported cross-bred lambs. the criterion of efficacy was the ability of the vaccines to reduce the extent of pneumonic lesions in vaccinated as against unvaccinated control lambs. the oav produced at this institute significantly reduced the lung lesions at p less than 0.05 l ...	1991	1959015
in-vitro activities of penicillin, amoxycillin and certain cephalosporins, including cefpodoxime, against human isolates of pasteurella multocida.		1991	1960130
evidence that arachidonic acid influences hen granulosa cell steroidogenesis and plasminogen activator activity by a protein kinase c-independent mechanism.	we recently proposed that arachidonic acid serves as a second messenger within granulosa cells from the largest preovulatory follicle of the hen. the present studies were conducted to determine whether the inhibitory effects of arachidonic acid on lh-induced camp accumulation and on the ability of cells to convert 25-hydroxycholesterol to progesterone are mediated via the protein kinase c pathway. furthermore, we determined the effects of arachidonic acid on plasminogen activator activity in gra ...	1990	1963326
h(+)-stimulated release of prostaglandin e2 and cyclic adenosine 3',5'-monophosphoric acid and their relationship to bone resorption in neonatal mouse calvaria cultures.	the addition of protons to the medium of neonatal mouse calvaria cultures stimulated bone resorption and release of calcium into the medium. in addition, added protons significantly increased the release of prostaglandin e2 (pge2) and cyclic adenosine 3',5'-monophosphoric acid (camp) from the bones. indomethacin significantly inhibited the release of calcium, pge2 and camp from proton-treated cultures. the positive control, parathyroid hormone (pth)-treated cultures, also gave rise to bone resor ...	1990	1964815
drug-susceptibility and isolation of a plasmid in haemophilus (actinobacillus) pleuropneumoniae.	we isolated 56 haemophilus (actinobacillus) pleuropneumoniae strains from the pneumonic porcine lung tissues and tested them for antimicrobial susceptibility. two drug-resistant strains were obtained. one, named kh-265, was resistant to streptomycin (sm) and sulfonamide (sa), and the other, named kh-195, was resistant to tetracycline (tc). the minimum inhibitory concentrations (mics) of drugs for resistant strains were 100 micrograms/mliters for sm, 3200 micrograms/mliters for sa, and 12.5 micro ...	1990	1968988
inhibition by anti-cd2 monoclonal antibodies of anti-cd3-induced t cell-dependent b cell activation.	anti-cd3 mab can activate t cells to help in b cell activation as detected by late events, such as maturation of b cells into ig-secreting cells (igsc), or by early events, such as b cell surface expression of the activation marker cd23. two different anti-cd2 mab each inhibited anti-cd3-induced t cell-dependent b cell activation in a dose-dependent fashion. neither irradiation of the t cells prior to culture nor depletion of cd8+ cells abrogated the inhibitory effects of anti-cd2 mab. despite t ...	2007	1976440
[pasteurella multocida (type d and a) and atrophic rhinitis of swine--hemagglutination, fimbriae and adhesion in vitro in the nasal mucosa of swine fetuses].	79 strains of p. multocida were investigated, mostly isolated from porcine nasal cavities, and a mannose-resistant hemagglutination with guinea pig and human group 0, but not with porcine erythrocytes was found. fimbriae as adhesins were demonstrated only on 2 strains. a correlation between capsular type, hemagglutination, fimbriation and toxigenicity on the examined p. multocida strains was not observed. three strains were investigated for the adherence to the nasal mucosa of neonatal pigs; agg ...	1990	1980059
a monoclonal antibody against a pasteurella multocida outer membrane protein protects rabbits and mice against pasteurellosis.	monoclonal antibodies (mabs) directed against the 37.5-kda outer membrane protein were produced by fusing myeloma cells with spleen cells obtained from mice immunized with a pathogenic strain of pasteurella multocida isolated from a rabbit. desirable mabs were selected by enzyme-linked immunosorbent assay, whole-cell radioimmunoprecipitation (wc-rip), and western blot (immunoblot) analysis. wc-rip and western blot analyses, using mab 1608 adsorbed with intact p. multocida cells and the eluted ma ...	1991	1987031
freeze-substitution of gram-negative eubacteria: general cell morphology and envelope profiles.	freeze-substitution was performed on strains of escherichia coli, pasteurella multocida, campylobacter fetus, vibrio cholerae, pseudomonas aeruginosa, pseudomonas putida, aeromonas salmonicida, proteus mirabilis, haemophilus pleuropneumoniae, caulobacter crescentus, and leptothrix discophora with a substitution medium composed of 2% osmium tetroxide and 2% uranyl acetate in anhydrous acetone. a thick periplasmic gel ranging from 10.6 to 14.3 nm in width was displayed in e. coli k-12, k30, and hi ...	1991	1999383
pasteurella multocida toxin, a potent mitogen, increases inositol 1,4,5-trisphosphate and mobilizes ca2+ in swiss 3t3 cells.	pasteurella multocida toxin, both native and recombinant, is an extremely potent mitogen for swiss 3t3 cells and acts to enhance the formation of total inositol phosphates (rozengurt, e., higgins, t., changer, n., lax, a.j., and staddon, j.m. (1990) proc. natl. acad. sci. u.s.a. 87, 123-127). p. multocida toxin also stimulates diacylglycerol production and activates protein kinase c (staddon, j.m., chanter, n., lax, a.j., higgins, t.e., and rozengurt, e. (1990) j. biol. chem. 265, 11841-11848). ...	1991	2002031
[pasteurella multocida infections: bites by dogs or cats?].	annually 50,000 to 100,000 animal bites are seen by physicians in the netherlands. infections of these bite wounds frequently occur. pasteurella multocida is one of the main causes of these infections and many serious complications may occur. we present 3 patients with disturbances in wound healing after animal bites or scratches due to infection with p. multocida. in view of the high infection ratio after cat bites we advise giving amoxicillin/clavulanic acid (augmentin) for 5 days as prophylax ...	1991	2002857
antibodies to outer membrane proteins but not to lipopolysaccharide inhibit pulmonary proliferation of pasteurella multocida in mice.	the role of rabbit antibodies against pasteurella multocida outer membrane proteins and lipopolysaccharides (lps) in resistance remains unknown. pooled immune sera against p. multocida outer membranes were prepared from specific-pathogen-free rabbits immunized with sucrose gradient-purified p. multocida outer membranes. western immunoblotting showed that purified outer membrane protein antibodies reacted strongly against the outer membrane proteins but not the purified lps. affinity-purified lps ...	1991	2004825
case control study of fowl cholera in meat turkeys in california from august 1985 through july 1986 [corrected].	from aug 1985 through july 1986, 720 meat turkey flocks on 160 california premises were monitored and outbreaks of fowl cholera (pasteurella multocida) were investigated. data from 43 outbreak (case) flocks were compared with data from 43 nonoutbreak (control) flocks. outbreak flocks, compared with control flocks, were more likely to be located on premises with higher maximal bird capacity and history of fowl cholera outbreaks. the overall impression was that flocks in larger, newer, more intens ...	1991	2012330
meningitis due to pasteurella multocida.		1991	2017627
acute airsacculitis in turkeys inoculated with cell-free culture filtrate of pasteurella multocida.	twenty-six female and 26 male turkeys, inoculated into the caudal thoracic air sacs with cell-free culture filtrate of pasteurella multocida strain r44/6, were examined from 0 to 6 hours post-inoculation and compared with 26 female and 26 male sham-inoculated control turkeys given brain-heart-infusion broth. the air sac reacted rapidly with exudation of heterophils. microscopically, low numbers of heterophils were present within air sac blood vessels and also perivascularly by 0.5 hour after ino ...	1991	2017827
[late post-pneumonectomy hematogenous pyothorax. apropos of 3 cases].	the authors describe three cases of patients who had previously undergone a pneumonectomy (two for cancer, one for bronchiectasis) with a favourable postoperative course, who subsequently developed pyothorax in the thoracic cavity. the bacteria isolated where in the first patient, pasteurella multocida; in the second, campylobacter foetus foetus; in the third, a variety of anaerobic organisms. the characteristic of the organisms allow us to exclude the possibility that these cases of pyothorax w ...	1991	2018342
determination of affinity of pasteurella multocida isolates for porcine respiratory tract mucus, and partial characterization of the receptors.	the ability of 25 pasteurella multocida isolates to adhere in vitro to porcine respiratory tract mucus was examined. microplate wells were coated with crude mucus preparation, then bacteria were added. after incubation, unbound bacteria were removed by washing, and the number of mucus-bound bacteria was estimated by quantitation of the adherent colony-forming units and by use of an elisa. pasteurella multocida had affinity to respiratory tract mucus, although significant differences were not obs ...	1991	2021250
aerobic bacteria from nasal discharge of goats suffering from clinical ppr: isolation and identification.	bacteriological isolation of aerobic bacteria from nasal discharge of achondroplastic west african dwarf goats showing clinical signs of peste des petits ruminants (ppr), and the laboratory procedures carried out for the identification of the isolates are described. from a total of forty nasal swabs obtained seventy five isolates were recovered. the percentage frequency of isolation of different organisms in descending order of occurrence is as follows: staphylococcus 44.0%; streptococcus 22.67% ...	1991	2023545
resistance to trimethoprim and 2,4-diamino-6,7-diisopropyl-pteridine (0/129) in pasteurella haemolytica.	thirteen strains of pasteurella haemolytica resistant to moderate levels of trimethoprim (mics from 8 to 64 micrograms/ml) and 0/129 (mics from 16 to 64 micrograms/ml) were isolated from bovine specimens. two strains, cnp330 and cnp334, were studied and found to harbour various plasmids but all attempts to cure trimethoprim resistance were unsuccessful. resistance characters were not transferable to escherichia coli or to pasteurella multocida by conjugation and to e. coli by transformation. the ...	1991	2024433
reclassification of german, british and dutch isolates of so-called pasteurella multocida obtained from pneumonic calf lungs.	the taxonomic relationship of 131 strains previously identified as pasteurella multocida obtained from calf pneumonia in west germany, united kingdom and netherlands was investigated by extended phenotypic and limited genotypic characterization. twenty-four strains were classified as p. multocida ssp. multocida, 15 strains as p. avium biovar 2 and 13 strains as p. canis biovar 2. sixty-five and five strains were tentatively classified as ornithine negative p. multocida ssp. multocida and p. mult ...	1991	2024434
a survey of potential virulence markers from avian strains of pasteurella multocida.	twenty-four isolates of pasteurella multocida from clinical cases of fowl cholera and the clemson university vaccine strain were surveyed for the presence of potential virulence markers. membrane proteins, enzymatic activity of the membrane proteins, and carbohydrate fermentation patterns were also determined to demonstrate phenotypic relationships within the groups. few differences were found in these phenotypic characteristics among the isolates. almost all the organisms produced siderophore a ...	1991	2024443
vaccination of turkeys with cell-free culture filtrate of pasteurella multocida.	turkeys given cell-free culture filtrate (ccf) of pasteurella multocida strain r44/6 orally, via air sacs, or subcutaneously mixed 1:1 with incomplete freund's adjuvant (ifa) at 6 and 9.5 weeks of age were compared with negative controls given bacteriologic medium and positive controls vaccinated with a commercial bacterin. at 13 weeks of age, serum antibody titers to p. multocida were detectable only in turkeys given ccf in ifa (low titers) and positive control turkeys (high titers), at which t ...	1991	2029246
effects of adjuvant-augmented germling vaccines in turkey poults challenged with aspergillus fumigatus.	turkey poults were vaccinated with combinations of two different germling preparations and three adjuvants (n-acetylmuranyl-l-alanyl-d-isoglutamine, pasteurella multocida lipopolysaccharide [lps], and avridine) at 1 and 2 weeks of age, and their immunity was challenged by sublethal exposure to aerosols of aspergillus fumigatus conidia at 1 month of age. fewer turkeys in the groups given vaccines prepared from germlings grown on dorset's and henley's medium (d&h) had organisms in lung tissue at 2 ...	1991	2029265
development of pneumonia in desert bighorn sheep after exposure to a flock of exotic wild and domestic sheep.	from 1986 to 1989, 5 desert bighorn sheep (3 ovis canadensis mexicana and 2 o c nelsoni), ranging in age from 2 to 3 years, were exposed to a flock of exotic wild and domestic sheep to potentially achieve naturally acquired pneumonia. pasteurella multocida was isolated from nasal samples from 4 of 6 sheep randomly sampled from the flock. bighorn sheep were exposed individually and each exposure period was a trial. treatment before and after exposure varied and included combinations of alpha inte ...	1991	2032914
the cytotoxin of actinobacillus pleuropneumoniae (pleurotoxin) is distinct from the haemolysin and is associated with a 120 kda polypeptide.	mutants of actinobacillus pleuropneumoniae strain hk 361 (serotype 2) were isolated which were deficient in type ii (ca2(+)-dependent) haemolysin activity (hly-). some of the hly- mutants secreted a potent, heat-labile extracellular cytotoxic activity against porcine alveolar macrophages. comparison of cell-free culture supernatant from the parent strain and some hly- mutants by sds-page and immunoblotting revealed the loss of a major extracellular polypeptide of 109 kda. two hly- mutants which ...	1991	2033378
telescoping plugged catheter. an unusual way of diagnosing pasteurella multocida pneumonia.	we report a case of pasteurella multocida pneumonia and its unusual clinical presentation. we also discuss the rarity of its diagnosis by tpc specimens and the delay in both an adequate diagnosis and treatment.	1991	2036840
comparison and analysis of the nucleotide sequences of pilin genes from haemophilus influenzae type b strains eagan and m43.	previous studies have demonstrated antigenic differences among the pili expressed by various strains of haemophilus influenzae type b (hib). in order to understand the molecular basis for these differences, the structural gene for pilin was cloned from hib strain eagan (p+) and the nucleotide sequence was compared to those of strains m43 (p+) and 770235 b0f+, which had been previously determined. the pilin gene of hib strain eagan (p+) had a 648-bp open reading frame that encoded a 20-amino-acid ...	1991	2037360
sir frederick hobday memorial lecture. all wind and water: some progress in the study of equine gut motility.		1991	2044514
coronary reserve in patients with aortic valve disease before and after successful aortic valve replacement.	in patients with aortic valve disease and normal coronary angiograms coronary reserve was determined by the coronary sinus thermodilution technique. three groups of patients were studied: 37 preoperative patients; 18 different patients 12-52 months after aortic valve replacement and seven control subjects with no cardiac disease. coronary flow ratio (dipyridamole/rest) was diminished in preoperative compared with postoperative patients (1.66 +/- 0.44 vs 2.22 +/- 0.85; p less than 0.05) as well a ...	2007	2044545
glucagon and clonidine testing in the diagnosis of pheochromocytoma.	we assessed the sensitivity and specificity of glucagon stimulation and clonidine suppression tests in the diagnosis of pheochromocytoma in 113 hypertensive patients, 39 with and 74 without the tumor. in the glucagon stimulation test, blood was sampled 2 minutes after intravenous injection of 0.28 mumol (1 mg) glucagon, and in the clonidine suppression test, blood was sampled 3 hours after administration of oral clonidine, 1.30 mumol (0.3 mg)/70 kg body wt. baseline levels of catechols in antecu ...	2007	2045133