Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| evolution, expression, and function of nonneuronal ligand-gated chloride channels in drosophila melanogaster. | ligand-gated chloride channels have established roles in inhibitory neurotransmission in the nervous systems of vertebrates and invertebrates. paradoxically, expression databases in drosophila melanogaster have revealed that three uncharacterized ligand-gated chloride channel subunits, cg7589, cg6927, and cg11340, are highly expressed in nonneuronal tissues. furthermore, subunit copy number varies between insects, with some orders containing one ortholog, whereas other lineages exhibit copy numb ... | 2016 | 27172217 |
| an rna-dependent rna polymerase gene in bat genomes derived from an ancient negative-strand rna virus. | endogenous bornavirus-like l (ebll) elements are inheritable sequences derived from ancient bornavirus l genes that encode a viral rna-dependent rna polymerase (rdrp) in many eukaryotic genomes. here, we demonstrate that bats of the genus eptesicus have preserved for more than 11.8 million years an ebll element named eebll-1, which has an intact open reading frame of 1,718 codons. the eebll-1 coding sequence revealed that functional motifs essential for mononegaviral rdrp activity are well conse ... | 2016 | 27174689 |
| gravid anopheles gambiae sensu stricto avoid ovipositing in bermuda grass hay infusion and it's volatiles in two choice egg-count bioassays. | a number of mosquito species in the culex and aedes genera prefer to lay eggs in bermuda grass (cynodon dactylon) hay infusions compared to water alone. these mosquitoes are attracted to volatile compounds from the hay infusions making the infusions effective baits in gravid traps used for monitoring vectors of arboviral and filarial pathogens. since bermuda grass is abundant and widespread, it is plausible to explore infusions made from it as a potential low cost bait for outdoor monitoring of ... | 2016 | 27177033 |
| dsrna-mediated targeting of ribosomal transcripts rps6 and rpl26 induces long-lasting and significant reductions in fecundity of the vector aedes aegypti. | ribosomal transcripts produce critical proteins that are involved in most cellular production processes. targeting ribosomal transcripts has produced mortality in mites and ticks but the effect of ribosomal transcript knockdown has not been thoroughly examined in mosquitoes. we examine the effects of triggers targeting four ribosomal proteins (rp) transcripts. although no significant mortality was observed after dsrna microinjection and subsequent blood feeding, significant contrasts were observ ... | 2016 | 27180677 |
| functional and immunohistochemical characterization of cceae3a, a carboxylesterase associated with temephos resistance in the major arbovirus vectors aedes aegypti and ae. albopictus. | temephos is a major organophosphate (op) larvicide that has been used extensively for the control of aedes albopictus and aedes aegypti, the major vectors for viral diseases, such as dengue fever, zika and chikungunya. resistance to temephos has been recently detected and associated with the upregulation of carboxylesterases (cces) through gene amplification, in both species. here, we expressed the cceae3a genes which showed the most striking up-regulation in resistant aedes strains, using the b ... | 2016 | 27180726 |
| novel lesions of bones and joints associated with chikungunya virus infection in two mouse models of disease: new insights into disease pathogenesis. | chikungunya virus is an arbovirus spread predominantly by aedes aegypti and ae. albopictus mosquitoes, and causes debilitating arthralgia and arthritis. while these are common manifestations during acute infection and it has been suggested they can recur in patients chronically, gaps in knowledge regarding the pathogenesis still exist. two established mouse models were utilized (adult irf 3/7 -/- -/- and wild-type c57bl/6j mice) to evaluate disease manifestations in bones and joints at various t ... | 2016 | 27182740 |
| the influence of larval competition on brazilian wolbachia-infected aedes aegypti mosquitoes. | with field releases starting in brazil, particular interest must be given to understanding how the endosymbiotic bacterium wolbachia pipientis affects aedes aegypti mosquitoes with a brazilian genetic background. currently, there is limited information on how the bacterium affects phenotypic traits such as larval development rate, metabolic reserves and morphometric parameters in ae. aegypti. here, we analyze for the first time, the effect of wolbachia on these key phenotypes and consider how th ... | 2016 | 27183820 |
| a critical role for the drosophila dopamine d1-like receptor dop1r2 at the onset of metamorphosis. | insect metamorphosis relies on temporal and spatial cues that are precisely controlled. previous studies in drosophila have shown that untimely activation of genes that are essential to metamorphosis results in growth defects, developmental delay and death. multiple factors exist that safeguard these genes against dysregulated expression. the list of identified negative regulators that play such a role in drosophila development continues to expand. | 2016 | 27184815 |
| mammalian african trypanosome vsg coat enhances tsetse's vector competence. | tsetse flies are biological vectors of african trypanosomes, the protozoan parasites responsible for causing human and animal trypanosomiases across sub-saharan africa. currently, no vaccines are available for disease prevention due to antigenic variation of the variant surface glycoproteins (vsg) that coat parasites while they reside within mammalian hosts. as a result, interference with parasite development in the tsetse vector is being explored to reduce disease transmission. a major bottlene ... | 2016 | 27185908 |
| an evidence-based review on medicinal plants used as insecticide and insect repellent in traditional iranian medicine. | insects can be the cause of major ecological problems; they can transmit microbes and parasites that affect humans, and damage food crops, trees, and homes. the total economic cost of insect-related damage and disease is immeasurable. in traditional iranian medicine (tim), several medicinal plants have been identified as insecticides or insect repellents, but many of them are still unknown. therefore, the aim of this study was to review the insecticidal or insect repellent activity of certain me ... | 2016 | 27186389 |
| biological screening of selected pacific northwest forest plants using the brine shrimp (artemia salina) toxicity bioassay. | the brine shrimp (artemia salina) bioassay was used to screen 211 methanol extracts from 128 species of pacific northwest plants in search of general cytotoxic activity. strong toxicity (lc50 < 100 µg/ml) was found for 17 extracts from 13 species, with highest activity observed for angelica arguta roots at <10 µg/ml. notably, four species of cedar trees and one of juniper in the family cupressaceae dominated this group with lc50 for heartwood extracts ranging from 15 to 89 µg/ml. moderate toxici ... | 2016 | 27186474 |
| evidence for the induction of key components of the notch signaling pathway via deltamethrin and azamethiphos treatment in the sea louse caligus rogercresseyi. | the extensive use of organophosphates and pyrethroids in the aquaculture industry has negatively impacted parasite sensitivity to the delousing effects of these antiparasitics, especially among sea lice species. the notch signaling pathway is a positive regulator of abc transporter subfamily c expression and plays a key role in the generation and modulation of pesticide resistance. however, little is known about the molecular mechanisms behind pesticide resistance, partly due to the lack of geno ... | 2016 | 27187362 |
| personal protection of permethrin-treated clothing against aedes aegypti, the vector of dengue and zika virus, in the laboratory. | the dengue and zika viruses are primarily transmitted by aedes aegypti mosquitoes, which are most active during day light hours and feed both in and outside of the household. personal protection technologies such as insecticide-treated clothing could provide individual protection. here we assessed the efficacy of permethrin-treated clothing on personal protection in the laboratory. | 2016 | 27187593 |
| [infestation status aedes albopictus and related mosquito-borne infectious disease risk in central urban area in shanghai]. | to evaluate aedes albopictus infestation status in the central urban area of shanghai, and analyze the related epidemic risk of mosquito-borne infectious disease. | 2016 | 27188346 |
| entomological assessment of yellow fever-epidemic risk indices in benue state, nigeria, 2010-2011. | yellow fever (yf) is a vector-borne disease affecting humans and non-human primates in tropical areas. in the past, there have been pockets of yf outbreaks in nigeria that resulted in preventable deaths. surveillance efforts towards avoiding another outbreak have been put in place with the aim of early detection and control. however, risk indices relating to the density of immature yf-mosquito vectors are given little consideration even though it is the first step in curbing a possible outbreak. ... | 2016 | 27189925 |
| magnitude of neglected tropical diseases in indonesia at postmillennium development goals era. | the world will enter the postmillennium development goals 2015 era. the achievements of the millennium development goals (mdgs) as a global development target need to be evaluated. a sustainable new reasonable target is important for neglected tropical diseases (ntd) elimination in indonesia. this review describes the ntd situation in indonesia and highlights problems beneath the ntd transmission. multidisciplinary approach is a promising strategy to help the marginalized people. | 2016 | 27190525 |
| mathematical model of three age-structured transmission dynamics of chikungunya virus. | we developed a new age-structured deterministic model for the transmission dynamics of chikungunya virus. the model is analyzed to gain insights into the qualitative features of its associated equilibria. some of the theoretical and epidemiological findings indicate that the stable disease-free equilibrium is globally asymptotically stable when the associated reproduction number is less than unity. furthermore, the model undergoes, in the presence of disease induced mortality, the phenomenon of ... | 2016 | 27190548 |
| reemergence of dengue in southern texas, 2013. | during a dengue epidemic in northern mexico, enhanced surveillance identified 53 laboratory-positive cases in southern texas; 26 (49%) patients acquired the infection locally, and 29 (55%) were hospitalized. of 83 patient specimens that were initially igm negative according to elisa performed at a commercial laboratory, 14 (17%) were dengue virus positive by real-time reverse transcription pcr performed at the centers for disease control and prevention. dengue virus types 1 and 3 were identified ... | 0 | 27191223 |
| molecular characterization and function analysis of the vitellogenin receptor from the cotton bollworm, helicoverpa armigera (hübner) (lepidoptera, noctuidae). | developing oocytes accumulate plentiful yolk protein during oogenesis through receptor-mediated endocytosis. the vitellogenin receptor (vgr), belonging to the low-density lipoprotein receptor (ldlr) family, regulates the absorption of yolk protein. in this work, the full-length vitellogenin receptor (havgr) in the cotton bollworm helicoverpa armigera was identified, encoding a 1817 residue protein. sequence alignment revealed that the sequence of havgr contained all of the conservative structura ... | 2016 | 27192057 |
| estimated zika virus importations to europe by travellers from brazil. | given the interconnectivity of brazil with the rest of the world, zika virus (zikv) infections have the potential to spread rapidly around the world via viremic travellers. the extent of spread depends on the travel volume and the endemicity in the exporting country. in the absence of reliable surveillance data, we did mathematical modelling to estimate the number of importations of zikv from brazil into europe. | 2016 | 27193266 |
| urban climate versus global climate change-what makes the difference for dengue? | the expansion in the geographical distribution of vector-borne diseases is a much emphasized consequence of climate change, as are the consequences of urbanization for diseases that are already endemic, which may be even more important for public health. in this paper, we focus on dengue, the most widespread urban vector-borne disease. largely urban with a tropical/subtropical distribution and vectored by a domesticated mosquito, aedes aegypti, dengue poses a serious public health threat. temper ... | 2016 | 27197685 |
| an infectious cdna clone of zika virus to study viral virulence, mosquito transmission, and antiviral inhibitors. | the asian lineage of zika virus (zikv) has recently caused epidemics and severe disease. unraveling the mechanisms causing increased viral transmissibility and disease severity requires experimental systems. we report an infectious cdna clone of zikv that was generated using a clinical isolate of the asian lineage. the cdna clone-derived rna is infectious in cells, generating recombinant zikv. the recombinant virus is virulent in established zikv mouse models, leading to neurological signs relev ... | 2016 | 27198478 |
| experimental infection of rhodnius prolixus (hemiptera, triatominae) with mycobacterium leprae indicates potential for leprosy transmission. | leprosy is a chronic dermato-neurological disease caused by infection with mycobacterium leprae. in 2013 almost 200,000 new cases of leprosy were detected around the world. since the first symptoms take from years to decades to appear, the total number of asymptomatic patients is impossible to predict. although leprosy is one of the oldest records of human disease, the mechanisms involved with its transmission and epidemiology are still not completely understood. in the present work, we experime ... | 2016 | 27203082 |
| exposure to aedes aegypti bites induces a mixed-type allergic response following salivary antigens challenge in mice. | classical studies have shown that aedes aegypti salivary secretion is responsible for the sensitization to mosquito bites and many of the components present in saliva are immunogenic and capable of inducing an intense immune response. therefore, we have characterized a murine model of adjuvant-free systemic allergy induced by natural exposure to mosquito bites. balb/c mice were sensitized by exposure to a. aegypti mosquito bites and intranasally challenged with phosphate-buffered saline only or ... | 2016 | 27203689 |
| a cost-effectiveness tool for informing policies on zika virus control. | as zika virus continues to spread, decisions regarding resource allocations to control the outbreak underscore the need for a tool to weigh policies according to their cost and the health burden they could avert. for example, to combat the current zika outbreak the us president requested the allocation of $1.8 billion from congress in february 2016. | 2016 | 27205899 |
| yellow fever vaccination status and safety in hemodialysis patients. | the adverse effects of yellow fever (yf) vaccine in dialysis patients are not well known. there is concern about the risks and benefits of the vaccine in immunocompromised patients living in endemic areas, particularly given the risk of resurgence of urban yf with the spread of aedes aegypti mosquitoes. the purpose of this study was to assess the coverage and safety of yf vaccine in chronic dialysis patients. | 2016 | 27208638 |
| highly diversified zika viruses imported to china, 2016. | 0 | 27209301 | |
| flavivirus vaccines: innovate, invest, implement. | 2016 | 27211530 | |
| clinical profile of dengue fever in children: a study from southern odisha, india. | background. in india, dengue epidemics are becoming more frequent (who, 2008). the majority of dengue viral infections are self-limiting, but complications may cause high morbidity and mortality. objectives. to assess the clinical profile of the dengue infection in children less than 14 years of age and to evaluate the outcomes of dengue fever from september 2013 to august 2015 at the pediatric department of maharaja krishna chandra gajapati medical college, the largest tertiary care hospital of ... | 2016 | 27213083 |
| functional and biochemical characterization of three recombinant human glucose-6-phosphate dehydrogenase mutants: zacatecas, vanua-lava and viangchan. | glucose-6-phosphate dehydrogenase (g6pd) deficiency in humans causes severe disease, varying from mostly asymptomatic individuals to patients showing neonatal jaundice, acute hemolysis episodes or chronic nonspherocytic hemolytic anemia. in order to understand the effect of the mutations in g6pd gene function and its relation with g6pd deficiency severity, we report the construction, cloning and expression as well as the detailed kinetic and stability characterization of three purified clinical ... | 2016 | 27213370 |
| meta-analysis of dengue severity during infection by different dengue virus serotypes in primary and secondary infections. | dengue virus (denv) infection is currently a major cause of morbidity and mortality in the world; it has become more common and virulent over the past half-century and has gained much attention. thus, this review compared the percentage of severe cases of both primary and secondary infections with different serotypes of dengue virus. | 2016 | 27213782 |
| the effect of wolbachia on dengue outbreaks when dengue is repeatedly introduced. | use of the wolbachia bacterium is a proposed new strategy to reduce dengue transmission, which results in around 390 million individuals infected annually. in places with strong variations in climatic conditions such as temperature and rainfall, dengue epidemics generally occur only at a certain time of the year. where dengue is not endemic, the time of year in which imported cases enter the population plays a crucial role in determining the likelihood of outbreak occurrence. we use a mathematic ... | 2016 | 27217229 |
| molecular identification of mosquitoes (diptera: culicidae) in southeastern australia. | dna barcoding is a modern species identification technique that can be used to distinguish morphologically similar species, and is particularly useful when using small amounts of starting material from partial specimens or from immature stages. in order to use dna barcoding in a surveillance program, a database containing mosquito barcode sequences is required. this study obtained cytochrome oxidase i (coi) sequences for 113 morphologically identified specimens, representing 29 species, six trib ... | 2016 | 27217948 |
| primary dengue haemorrhagic fever in patients from northeast of brazil is associated with high levels of interferon-β during acute phase. | dengue is an acute febrile disease caused by the mosquito-borne dengue virus (denv) that according to clinical manifestations can be classified as asymptomatic, mild or severe dengue. severe dengue cases have been associated with an unbalanced immune response characterised by an over secretion of inflammatory cytokines. in the present study we measured type i interferon (ifn-i) transcript and circulating levels in primary and secondary denv infected patients. we observed that dengue fever (df) a ... | 0 | 27223651 |
| temporal dynamics and spatial patterns of aedes aegypti breeding sites, in the context of a dengue control program in tartagal (salta province, argentina). | since 2009, fundación mundo sano has implemented an aedes aegypti surveillance and control program in tartagal city (salta province, argentina). the purpose of this study was to analyze temporal dynamics of ae. aegypti breeding sites spatial distribution, during five years of samplings, and the effect of control actions over vector population dynamics. | 2016 | 27223693 |
| emerging infectious disease and fast-track publication: when public health gets priority over the formality of scholarly publishing. | 0 | 27223865 | |
| evocation to the dr. carlos j. finlay barres on the centennial of his death. | about the editorial of the professor guillermo llanos: "carlos j. finlay: the forgotten pasteur of america", a hundred years after his death and through a documental review, a summary of the life and work of this great man of science was conducted. finlay was a notable figure of the american medicine, he conceived a new infection way able to explain the propagation of the yellow fever, and added the possibility of their scientific confirmation by an experimental method. for all the above-mention ... | 2016 | 27226667 |
| species-specific temperature sensitivity of trpa1. | transient receptor potential ankyrin 1 (trpa1) is a polymodal ion channel sensitive to temperature and chemical stimuli. the importance of temperature and aversive chemical detection for survival has driven the evolutionary diversity of trpa1 sensitivity. this diversity can be observed in the various roles of trpa1 in different species, where it is proposed to act as a temperature-insensitive chemosensor, a heat transducer, a noxious cold transducer, or a detector of low-intensity heat for prey ... | 2015 | 27227025 |
| quantifying the epidemiological impact of vector control on dengue. | 2016 | 27227829 | |
| different effects of metarhizium anisopliae strains imi330189 and ibc200614 on enzymes activities and hemocytes of locusta migratoria l. | metarhizium is an important class of entomopathogenic fungi in the biocontrol of insects, but its virulence is affected by insect immunity. to clarify the mechanism in virulence of metarhizium, we compared the immunological differences in locusta migratoria l. when exposed to two strains of metarhizium anisopliae (ma). | 2016 | 27227835 |
| projected impact of dengue vaccination in yucatán, mexico. | dengue vaccines will soon provide a new tool for reducing dengue disease, but the effectiveness of widespread vaccination campaigns has not yet been determined. we developed an agent-based dengue model representing movement of and transmission dynamics among people and mosquitoes in yucatán, mexico, and simulated various vaccine scenarios to evaluate effectiveness under those conditions. this model includes detailed spatial representation of the yucatán population, including the location and mov ... | 2016 | 27227883 |
| zika in the united states of america and a fateful 1969 decision. | the united states gulf coast's current risk to zika transmitted by aedes aegypti mosquitoes can be traced back to some important federal health policy decisions made during the 1960s. | 2016 | 27227971 |
| effects of temperature on the life cycle, expansion, and dispersion of aedes aegypti (diptera: culicidae) in three cities in paraiba, brazil. | the mosquito aedes aegypti is the primary vector of dengue and is common throughout tropical and subtropical regions. its distribution is modulated by environmental factors, such as temperature. this study aimed to evaluate the influence of temperature on the life cycle and expansion of ae. aegypti populations in the cities of campina grande, joão pessoa, and patos. samples of ae. aegypti were collected in the three cities and raised in the laboratory. we assessed the life cycles of the three ae ... | 2016 | 27232118 |
| first case of zika virus infection in a hiv+ patient. | zika virus is an enveloped, single-stranded rna virus that belongs to the flavivirus genre. as with arbovirus, it is transmitted by arthropods (mosquitoes), both aedes aegypti (urban) and albopictus (rural). zika virus was first isolated in 1947 from monkeys in uganda. the first human cases were reported in 1952 in east africa. outbreaks were reported in micronesia (2007), polynesia (2013), and chile (2014). both diagnostic procedures and therapeutics are poorly developed. serological tests cros ... | 2017 | 27232506 |
| correction: spread of the invasive mosquitoes aedes aegypti and aedes albopictus in the black sea region increases risk of chikungunya, dengue, and zika outbreaks in europe. | [this corrects the article doi: 10.1371/journal.pntd.0004664.]. | 2016 | 27232603 |
| outwitting dengue threat and epidemics resurgence in asia-pacific countries: strengthening integrated dengue surveillance, monitoring and response systems. | dengue is still a substantial vector-borne viral disease threat and burden of public health importance worldwide. this situation is complicated by dengue virus unprecedented resurgence and persistence of varied serotypes in endemic-prone areas, and man-made and natural activities consequences that promote vector emergence, transmission dynamics and spread across the asia-pacific region. there is an urgent need to strengthen operational and contextual surveillance-response research in improving e ... | 2016 | 27233238 |
| utilization and assessment of throat swab and urine specimens for diagnosis of chikungunya virus infection. | chikungunya is a mosquito-borne infection with clinical presentation of fever, arthralgia, and rash. the etiological agent chikungunya virus (chikv) is generally transmitted from primates to humans through the bites of infected aedes aegypti and aedes albopictus mosquitoes. outbreaks of chikungunya occur commonly with varied morbidity, mortality, and sequele according to the epidemiological, ecological, seasonal, and geographical impact. investigations are required to be conducted as a part of t ... | 2016 | 27233262 |
| chikungunya virus infection of aedes mosquitoes. | in vivo infection of mosquitoes is an important method to study and characterize arthropod-borne viruses. chikungunya virus (chikv) is a mosquito-borne alphavirus that is transmitted primarily by aedes mosquitoes. in this chapter, we describe a protocol for infection of chikv in two species of aedes mosquitoes, aedes aegypti and aedes albopictus, together with the isolation of chikv in different parts of the infected mosquito such as midgut, legs, wings, salivary gland, head, and saliva. this al ... | 2016 | 27233266 |
| a glance at subgenomic flavivirus rnas and micrornas in flavivirus infections. | the family flaviviridae comprises a wide variety of viruses that are distributed worldwide, some of which are associated with high rates of morbidity and mortality. there are neither vaccines nor antivirals for most flavivirus infections, reinforcing the importance of research on different aspects of the viral life cycle. during infection, cytoplasmic accumulation of rna fragments mainly originating from the 3' utrs, which have been designated subgenomic flavivirus rnas (sfrnas), has been detect ... | 2016 | 27233361 |
| zika virus infection: current concerns and perspectives. | the zika virus outbreaks highlight the growing importance need for a reliable, specific and rapid diagnostic device to detect zika virus, as it is often recognized as a mild disease without being identified. many zika virus infection cases have been misdiagnosed or underreported because of the non-specific clinical presentation. the aim of this review was to provide a critical and comprehensive overview of the published peer-reviewed evidence related to clinical presentations, various diagnostic ... | 2016 | 27236440 |
| global distribution and environmental suitability for chikungunya virus, 1952 to 2015. | chikungunya fever is an acute febrile illness caused by the chikungunya virus (chikv), which is transmitted to humans by aedes mosquitoes. although chikungunya fever is rarely fatal, patients can experience debilitating symptoms that last from months to years. here we comprehensively assess the global distribution of chikungunya and produce high-resolution maps, using an established modelling framework that combines a comprehensive occurrence database with bespoke environmental correlates, inclu ... | 0 | 27239817 |
| synthetic strategy and antiviral evaluation of diamide containing heterocycles targeting dengue and yellow fever virus. | high-throughput screening of a subset of the cd3 chemical library (centre for drug design and discovery; ku leuven) provided us with a lead compound 1, displaying low micromolar potency against dengue virus and yellow fever virus. within a project aimed at discovering new inhibitors of flaviviruses, substitution of its central imidazole ring led to synthesis of variably substituted pyrazine dicarboxylamides and phthalic diamides, which were evaluated in cell-based assays for cytotoxicity and ant ... | 2016 | 27240271 |
| a novel mosquito ubiquitin targets viral envelope protein for degradation and reduces virion production during dengue virus infection. | dengue virus (denv) is a mosquito-borne flavivirus that causes significant human disease and mortality in the tropics and subtropics. by examining the effects of virus infection on gene expression, and interactions between virus and vector, new targets for prevention of infection and novel treatments may be identified in mosquitoes. we previously performed a microarray analysis of the aedes aegypti transcriptome during infection with denv and found that mosquito ubiquitin protein ub3881 (aael003 ... | 2016 | 27241849 |
| species composition and habitat characterization of mosquito (diptera: culicidae) larvae in semi-urban areas of dhaka, bangladesh. | mosquito larvae are purely aquatic and develop in water bodies, the type of which is more or less specific to each species. therefore, a study was carried out to identify the habitat characters of different mosquito species along with their species composition in semi-urban area of dhaka in bangladesh during the month of may and june 2012. a total of 6088 mosquito larvae belonging to 12 species (aedes aegypti, aedes albopictus, anopheles barbirostris, anopheles peditaeniatus, anopheles vagus, cu ... | 2016 | 27241953 |
| wolbachia infections in natural anopheles populations affect egg laying and negatively correlate with plasmodium development. | the maternally inherited alpha-proteobacterium wolbachia has been proposed as a tool to block transmission of devastating mosquito-borne infectious diseases like dengue and malaria. here we study the reproductive manipulations induced by a recently identified wolbachia strain that stably infects natural mosquito populations of a major malaria vector, anopheles coluzzii, in burkina faso. we determine that these infections significantly accelerate egg laying but do not induce cytoplasmic incompati ... | 2016 | 27243367 |
| scoping review of the zika virus literature. | the global primary literature on zika virus (zikv) (n = 233 studies and reports, up to march 1, 2016) has been compiled using a scoping review methodology to systematically identify and characterise the literature underpinning this broad topic using methods that are documented, updateable and reproducible. our results indicate that more than half the primary literature on zikv has been published since 2011. the articles mainly covered three topic categories: epidemiology of zikv (surveillance an ... | 2016 | 27244249 |
| antifilarial activity of diterpenoids from taxodium distichum. | lymphatic filariasis caused by wuchereria bancrofti, brugia malayi and b. timori, is a debilitating disease with an adverse social and economic impact. the infection remains unabated in spite of treatment with existing antifilarial drugs diethylcarbamazine (dec) and ivermectin which are chiefly microfilaricides. there is therefore, need for macrofilaricides, embryostatic agents and better microfilaricides. in the present study we explored the antifilarial potential of crude extract and its molec ... | 2016 | 27245322 |
| combinatorial gene regulatory functions underlie ultraconserved elements in drosophila. | ultraconserved elements (uces) are discrete genomic elements conserved across large evolutionary distances. although uces have been linked to multiple facets of mammalian gene regulation their extreme evolutionary conservation remains largely unexplained. here, we apply a computational approach to investigate this question in drosophila, exploring the molecular functions of more than 1,500 uces shared across the genomes of 12 drosophila species. our data indicate that drosophila uces are hubs fo ... | 2016 | 27247329 |
| evaluation of alternative killing agents for aedes aegypti (diptera: culicidae) in the gravid aedes trap (gat). | the gravid aedes trap (gat) uses visual and olfactory cues to attract gravid aedes aegypti (l.) that are then captured when knocked down by a residual pyrethroid surface spray. however, the use of surface sprays can be compromised by poor availability of the spray and pesticide resistance in the target mosquito. we investigated several "alternative" insecticide and insecticide-free killing agents for use in the gat. this included long-lasting insecticide-impregnated nets (llins), vapor-active sy ... | 2016 | 27247350 |
| control of urban zika vectors: should we return to the successful paho/who strategy? | 2016 | 27249063 | |
| larvicidal and adulticidal activity of chroman and chromene analogues against susceptible and permethrin-resistant mosquito strains. | mosquitoes play a major role as vectors that transmit parasitic and viral diseases worldwide, especially in tropical and subtropical countries. mosquito borne diseases not only affect humans but they also affect livestock in many parts of the world. they carry diseases that are lethal to dogs and horses. dog heartworm disease (dirofilaria immitis) is a parasitic disease spread through mosquitoes. this disease is not limited to dogs, but it can affect other animals and humans as well. eastern equ ... | 2016 | 27249182 |
| attractiveness of volatiles from different body parts to the malaria mosquito anopheles coluzzii is affected by deodorant compounds. | mosquitoes display biting preferences among different sites of the human body. in addition to height or convection currents, body odour may play a role in the selection of these biting sites. previous studies have shown that skin emanations are important host-finding cues for mosquitoes. in this study, skin emanations were collected from armpits, hands and feet; the volatile profiles were analysed and tested for their attractiveness to the malaria mosquito anopheles coluzzii. skin emanations col ... | 2016 | 27251017 |
| myo-inositol phosphate synthase expression in the european eel (anguilla anguilla) and nile tilapia (oreochromis niloticus): effect of seawater acclimation. | a single mips gene (isyna1/ino1) exists in eel and tilapia genomes with a single myo-d-inositol 3-phosphate synthase (mips) transcript identified in all eel tissues, although two mips spliced variants [termed mips(s) and mips(l)] are found in all tilapia tissues. the larger tilapia transcript [mips(l)] results from the inclusion of the 87-nucleotide intron between exons 5 and 6 in the genomic sequence. in most tilapia tissues, the mips(s) transcript exhibits much higher abundance (generally >10- ... | 2016 | 27252471 |
| evaluation of sublethal effects of ipomoea cairica linn. extract on life history traits of dengue vectors. | plant derived insecticides have considerable potential for mosquito control because these products are safer than conventional insecticides. this study aimed to investigate sublethal activities of ipomoea carica or railway creeper crude acethonilic extract against life history trait of dengue vectors, aedes albopictus and aedes aegypti. the late third instar larvae of ae. albopictus and ae. aegypti were exposed to a sublethal dose at lc50 and larvae that survived were further cultured. overall, ... | 2016 | 27253746 |
| crowdsourcing vector surveillance: using community knowledge and experiences to predict densities and distribution of outdoor-biting mosquitoes in rural tanzania. | lack of reliable techniques for large-scale monitoring of disease-transmitting mosquitoes is a major public health challenge, especially where advanced geo-information systems are not regularly applicable. we tested an innovative crowd-sourcing approach, which relies simply on knowledge and experiences of residents to rapidly predict areas where disease-transmitting mosquitoes are most abundant. guided by community-based resource persons, we mapped boundaries and major physical features in three ... | 2016 | 27253869 |
| dengue, chikungunya … and the missing entity - zika fever: a new emerging threat. | zika virus (zikv), a relative newcomer from the flavivirus group that includes dengue, japanese encepahalitis and yellow fever, is one of the emerging pathogens that is fast transcending geographical boundaries. it is a vector-borne disease transmitted by the same aedes aegypti and aedes albopictus, which cause dengue and chikungunya. in addition to the vector-mediated transmission of zika fever, probable human-to-human transmission through exchange of body fluids, including sexual and perinatal ... | 2016 | 27257326 |
| epidemiological and virological characterizations of the 2014 dengue outbreak in guangzhou, china. | dengue used to be recognized as an imported and sporadic disease in china. since june 2014, an unexpected large dengue outbreak has attacked guangzhou, china, resulting in more than 40,000 cases. among the 1,942 laboratory-confirmed hospitalized dengue cases, 121 were diagnosed as severe dengue according to the 2009 who guideline, and 2 patients finally died. laboratory diagnosis and virus isolation demonstrated that the majority (96%) cases were caused by dengue virus serotype 1 (denv-1), and t ... | 2016 | 27257804 |
| seeing is believing: the nocturnal malarial mosquito anopheles coluzzii responds to visual host-cues when odour indicates a host is nearby. | the immediate aim of our study was to analyse the behaviour of the malarial mosquito anopheles coluzzii (an. gambiae species complex) near a human host with the ultimate aim of contributing to our fundamental understanding of mosquito host-seeking behaviour and the overall aim of identifying behaviours that could be exploited to enhance sampling and control strategies. | 2016 | 27260254 |
| vector competence of aedes albopictus and aedes aegypti (diptera: culicidae) for the den2-fj10 and den2-fj11 strains of the dengue 2 virus in fujian, china. | dengue is an acute, emerging, infectious disease transmitted by aedes mosquitoes that has become a serious global public health problem. the den2-fj10 and den2-fj11 strains of the dengue 2 virus were originally isolated from the serum of a patient with dengue fever in fujian province, china, in 1999. our data provide the first assessment of the vector competence of aedes mosquitoes with respect to the den2-fj10 and den2-fj11 strains of the dengue virus. there were significant differences in the ... | 2016 | 27260668 |
| toxicology of potassium channel-directed compounds in mosquitoes. | potential targets for new vector control insecticides are nerve and muscle potassium channels. in this study, the activities of known potassium channel blockers (4-aminopyridine, quinidine, and tetraethylammonium) and the insecticide propoxur were compared to three experimental catechols and several other compounds against anopheles gambiae and aedes aegypti mosquitoes. experimental catechol 1 was the most toxic experimental compound in all of the mortality assays conducted, but was at least 100 ... | 2016 | 27262624 |
| tetrapyrroles as endogenous tspo ligands in eukaryotes and prokaryotes: comparisons with synthetic ligands. | the 18 kda translocator protein (tspo) is highly 0conserved in eukaryotes and prokaryotes. since its discovery in 1977, numerous studies established the tspo's importance for life essential functions. for these studies, synthetic tspo ligands typically are applied. tetrapyrroles present endogenous ligands for the tspo. tetrapyrroles are also evolutionarily conserved and regulate multiple functions. tspo and tetrapyrroles regulate each other. in animals tspo-tetrapyrrole interactions range from e ... | 2016 | 27271616 |
| population genetics of the asian tiger mosquito aedes albopictus, an invasive vector of human diseases. | the asian tiger mosquito aedes albopictus is currently one of the most threatening invasive species in the world. native to southeast asia, the species has spread throughout the world in the past 30 years and is now present in every continent but antarctica. because it was the main vector of recent dengue and chikungunya outbreaks, and because of its competency for numerous other viruses and pathogens such as the zika virus, a. albopictus stands out as a model species for invasive diseases vecto ... | 2016 | 27273325 |
| leucokinin mimetic elicits aversive behavior in mosquito aedes aegypti (l.) and inhibits the sugar taste neuron. | insect kinins (leucokinins) are multifunctional peptides acting as neurohormones and neurotransmitters. in females of the mosquito vector aedes aegypti (l.), aedeskinins are known to stimulate fluid secretion from the renal organs (malpighian tubules) and hindgut contractions by activating a g protein-coupled kinin receptor designated "aedae-kr." we used protease-resistant kinin analogs 1728, 1729, and 1460 to evaluate their effects on sucrose perception and feeding behavior. in no-choice feedin ... | 2016 | 27274056 |
| spontaneous arterial hemorrhage as a complication of dengue. | bleeding complications of dengue hemorrhagic fever such as epistaxis, gum bleeding, gastrointestinal bleeding, hypermenorrhea, hematuria, and thrombocytopenia have been documented. a 49-year-old female presented with complaints of intermittent high-grade fever for the past 4 days, lower abdominal pain and altered sensorium for 1 day. laboratory investigations revealed severe anemia, mild thrombocytopenia, hypofibrinogenemia, and positive dengue serology. emergency ultrasound examination of the a ... | 0 | 27275081 |
| nucleotide composition of the zika virus rna genome and its codon usage. | rna viruses have genomes with a distinct nucleotide composition and codon usage. we present the global characteristics of the rna genome of zika virus (zikv), an emerging pathogen within the flavivirus genus. zikv was first isolated in 1947 in uganda, caused a widespread epidemic in south and central america and the caribbean in 2015 and has recently been associated with microcephaly in newborns. | 2016 | 27278486 |
| the brazilian zika virus strain causes birth defects in experimental models. | zika virus (zikv) is an arbovirus belonging to the genus flavivirus (family flaviviridae) and was first described in 1947 in uganda following blood analyses of sentinel rhesus monkeys. until the twentieth century, the african and asian lineages of the virus did not cause meaningful infections in humans. however, in 2007, vectored by aedes aegypti mosquitoes, zikv caused the first noteworthy epidemic on the yap island in micronesia. patients experienced fever, skin rash, arthralgia and conjunctiv ... | 0 | 27279226 |
| mass spectrometry analysis and transcriptome sequencing reveal glowing squid crystal proteins are in the same superfamily as firefly luciferase. | the japanese firefly squid hotaru-ika (watasenia scintillans) produces intense blue light from photophores at the tips of two arms. these photophores are densely packed with protein microcrystals that catalyse the bioluminescent reaction using atp and the substrate coelenterazine disulfate. the squid is the only organism known to produce light using protein crystals. we extracted microcrystals from arm tip photophores and identified the constituent proteins using mass spectrometry and transcript ... | 2016 | 27279452 |
| toxicity of boswellia dalzielii (burseraceae) leaf fractions against immature stages of anopheles gambiae (giles) and culex quinquefasciatus (say) (diptera: culicidae). | mosquitoes are vectors of several human pathogens, and great attention has recently been placed on insecticides from plant-derived products, in search for mosquito control agents. this study, thus, investigated the potency of boswellia dalzielii methanol leaf extract and its four fractions as mosquito ovicide, larvicide, and pupicide against anopheles gambiae and culex quinquefasciatus. the plant products were tested at the following concentrations: 125, 250, 500, 1000, and 2000 ppm on eggs and ... | 2016 | 27279752 |
| zika virus, elevation, and transmission risk. | zika virus has appeared in the americas in the form of a major outbreak, and is now known to cause birth defects when pregnant women are infected. as a result, the centers for disease control and prevention issued travel guidelines, in the form of an elevational risk definition: destinations below 2000m are considered as at-risk. | 2016 | 27280061 |
| insights into sexual precocity of female oriental river prawn macrobrachium nipponense through transcriptome analysis. | the oriental river prawn (macrobrachium nipponense) is the most prevalent aquaculture species in china. the sexual precocity in this species has received considerable attention in recent years because more and more individuals matured at a small size, which devalues the commercial production. in this study, we developed deep-coverage transcriptomic sequencing data for the ovaries of sexually precocious and normal sexually mature m. nipponense using next-generation rna sequencing technology and a ... | 2016 | 27280288 |
| new candidates for plant-based repellents against aedes aegypti. | based on an ethnobotanical study on use for plant species against mosquito bites in the kota tinggi district, johor state, malaysia, 3 plants selected for study, citrus aurantifolia (leaves), citrus grandis (fruit peel), and alpinia galanga (rhizome), were extracted using hydrodistillation to produce essential oils. these essential oils were then formulated as a lotion using a microencapsulation process and then tested for their repellent effect against aedes aegypti. n,n-diethyl-m-toluamide (de ... | 2016 | 27280349 |
| semi-field evaluation of metofluthrin-impregnated nets on host-seeking aedes aegypti and anopheles dirus. | the efficacy of a metofluthrin-impregnated net (min) known as the "mushikonazu" on the house entry behavior of female aedes aegypti and anopheles dirus mosquitoes was evaluated using a semi-field 50-m tunnel setup. while the min is labeled for the control of chironomids and moth flies, this study determined the feasibility of using the device, given its current construction and metofluthrin formulation, as a spatial repellent against mosquitoes. sentinel and cone bioassays were used to determine ... | 2016 | 27280351 |
| dengue vaccine: considerations before rollout in colombia. | 2016 | 27280803 | |
| evidence for natural vertical transmission of chikungunya viruses in field populations of aedes aegypti in delhi and haryana states in india-a preliminary report. | aedes aegypti and aedes albopictus are principal vectors for the transmission of chikungunya virus (chikv). india is a hub for both dengue and chikungunya infections and there are several reports of co-infection of dengue and chikungunya virus in the clinical scenario. the present pilot entomological survey was conducted to evaluate vertical transmission of chikv in aedes field populations. aedes immature (larvae and pupae) collection was done in 2012, over a period of six months from selected s ... | 2016 | 27282096 |
| reported distribution of aedes (stegomyia) aegypti and aedes (stegomyia) albopictus in the united states, 1995-2016 (diptera: culicidae). | aedes (stegomyia) aegypti (l.) and aedes (stegomyia) albopictus (skuse) transmit arboviruses that are increasing threats to human health in the americas, particularly dengue, chikungunya, and zika viruses. epidemics of the associated arboviral diseases have been limited to south and central america, mexico, and the caribbean in the western hemisphere, with only minor localized outbreaks in the united states. nevertheless, accurate and up-to-date information for the geographical ranges of ae. aeg ... | 2016 | 27282817 |
| zika: what we do and do not know based on the experiences of brazil. | zika virus, which was first discovered in 1947, has become a global threat to human health as it is rapidly spreading through latin america, the caribbean, the us and asia, after causing a large outbreak in the northeast region of brazil in 2015. there is ample evidence to support that zika virus is associated with neurological complications such as microcephaly. the review aims to provide an overview on the complex issues involved in the emergence of zika virus's neurological disorders and to d ... | 2016 | 27283140 |
| chemical composition and biological activity of essential oils from different species of piper from panama. | the chemical composition of leaf essential oils from 11 species of piper from panama was analyzed by a combination gc-fid and gc-ms procedures. six of them had sesquiterpene hydrocarbons as major constituents, three were characterized by monoterpene hydrocarbons, one by a diterpene, and one by a phenylpropanoid, dillapiole. the main components identified in each species were: cembratrienol (25.4 %) in piper augustum; β-pinene (26.6 %) in piper corrugatum; α-pinene (19.4 %) in piper curtispicum; ... | 2016 | 27286333 |
| somatostatin signaling system as an ancestral mechanism: myoregulatory activity of an allatostatin-c peptide in hydra. | the coordination of physiological processes requires precise communication between cells. cellular interactions allow cells to be functionally related, facilitating the maintaining of homeostasis. neuropeptides functioning as intercellular signals are widely distributed in metazoa. it is assumed that neuropeptides were the first intercellular transmitters, appearing early during the evolution. in cnidarians, neuropeptides are mainly involved in neurotransmission, acting directly or indirectly on ... | 2016 | 27288244 |
| effects of preexposure to deet on the downstream blood-feeding behaviors of aedes aegypti (diptera: culicidae) mosquitoes. | mosquito behavior is heavily influenced by the chemical molecules in the environment. this knowledge can be used to modify insect behaviors; particularly to reduce vector-host contact as a powerful method for disease prevention. n,n-diethyl-meta-toluamide (deet) is the most widely used insect repellent in the market and an excellent example of a chemical that has been used to modify insect behavior for disease prevention. however, genetic insensitivity and habituation in aedes aegypti (l.) mosqu ... | 2016 | 27288690 |
| gene family evolution reflects adaptation to soil environmental stressors in the genome of the collembolan orchesella cincta. | collembola (springtails) are detritivorous hexapods that inhabit the soil and its litter layer. the ecology of the springtail orchesella cincta is extensively studied in the context of adaptation to anthropogenically disturbed areas. here, we present a draft genome of an o. cincta reference strain with an estimated size of 286.8 mbp, containing 20,249 genes. in total, 446 gene families are expanded and 1,169 gene families evolved specific to this lineage. besides these gene families involved in ... | 2016 | 27289101 |
| antinociceptive effect of tephrosia sinapou extract in the acetic acid, phenyl-p-benzoquinone, formalin, and complete freund's adjuvant models of overt pain-like behavior in mice. | tephrosia toxicaria, which is currently known as tephrosia sinapou (buc'hoz) a. chev. (fabaceae), is a source of compounds such as flavonoids. t. sinapou has been used in amazonian countries traditional medicine to alleviate pain and inflammation. the purpose of this study was to evaluate the analgesic effects of t. sinapou ethyl acetate extract in overt pain-like behavior models in mice by using writhing response and flinching/licking tests. we demonstrated in this study that t. sinapou extract ... | 2016 | 27293981 |
| toxicological assessment of spinosad: implications for integrated control of aedes aegypti using larvicides and larvivorous fish. | integration of larvivorous fish and biolarvicides at low concentrations to control of mosquito larvae in field situations may result in a safer and more effective tool. however, the usefulness of integrated approach depends upon survival and ecological fitness of fish employed. thus, the aim of this study was to examine the genotoxic effects of combining different sublethal concentrations of spinosad, a naturally occurring neurotoxic insecticide, with male adult poecilid larvivorous guppy (poeci ... | 2016 | 27294296 |
| antiviral hammerhead ribozymes are effective for developing transgenic suppression of chikungunya virus in aedes aegypti mosquitoes. | the chikungunya virus (chikv) is an emerging pathogen with widespread distribution in regions of africa, india, and asia that threatens to spread into temperate climates with the introduction of its major vector, aedes albopictus. chikv causes a disease frequently misdiagnosed as dengue fever, with potentially life-threatening symptoms that can result in a longer-term debilitating arthritis. the increasing risk of spread from endemic regions via human travel and commerce and the current absence ... | 2016 | 27294950 |
| alphavirus infection: host cell shut-off and inhibition of antiviral responses. | alphaviruses cause debilitating disease in humans and animals and are transmitted by blood-feeding arthropods, typically mosquitoes. with a traditional focus on two models, sindbis virus and semliki forest virus, alphavirus research has significantly intensified in the last decade partly due to the re-emergence and dramatic expansion of chikungunya virus in asia, europe, and the americas. as a consequence, alphavirus-host interactions are now understood in much more molecular detail, and importa ... | 2016 | 27294951 |
| [zika virus and zika viral disease]. | since zika virus (zikv) has firstly been isolated in 1947, uganda, outbreaks of zika fever have been reported in many areas such as in africa, southeast asia and america. imported cases in china also have been reported. zika virus belongs to the family flaviviridae, genus flavivirus, and include africa subtype and asia subtype. it is a mosquito-borne virus primarily transmitted by aedes aegypti mosquitoes. sexual transmission, blood transmission and mother-to-fetus transmission were also reporte ... | 2016 | 27295893 |
| prospects and challenges of crispr/cas genome editing for the study and control of neglected vector-borne nematode diseases. | neglected tropical diseases caused by parasitic nematodes inflict an immense health and socioeconomic burden throughout much of the developing world. current estimates indicate that more than two billion people are infected with nematodes, resulting in the loss of 14 million disability-adjusted life years per annum. although these parasites cause significant mortality, they primarily cause chronic morbidity through a wide range of severe clinical ailments. treatment options for nematode infectio ... | 2016 | 27300487 |
| virus-like particles derived from pichia pastoris-expressed dengue virus type 1 glycoprotein elicit homotypic virus-neutralizing envelope domain iii-directed antibodies. | four antigenically distinct serotypes (1-4) of dengue viruses (denvs) cause dengue disease. antibodies to any one denv serotype have the potential to predispose an individual to more severe disease upon infection with a different denv serotype. a dengue vaccine must elicit homotypic neutralizing antibodies to all four denv serotypes to avoid the risk of such antibody-dependent enhancement in the vaccine recipient. this is a formidable challenge as evident from the lack of protective efficacy aga ... | 2016 | 27301568 |
| a cd36 ectodomain mediates insect pheromone detection via a putative tunnelling mechanism. | cd36 transmembrane proteins have diverse roles in lipid uptake, cell adhesion and pathogen sensing. despite numerous in vitro studies, how they act in native cellular contexts is poorly understood. a drosophila cd36 homologue, sensory neuron membrane protein 1 (snmp1), was previously shown to facilitate detection of lipid-derived pheromones by their cognate receptors in olfactory cilia. here we investigate how snmp1 functions in vivo. structure-activity dissection demonstrates that snmp1's ectod ... | 2016 | 27302750 |
| [hemorrhagic form of dengue fever observed at the infectious diseases department chu yalgado ouédraogo, burkina faso]. | dengue is a re-emerging arboviral disease in tropical countries. haemorrhagic form may be associated with circulatory failure and produce hypovolemic shock, which is often fatal. we report a series of three cases of hemorrhagic dengue observed at the infectious diseases department chu yalgado ouédraogo, ouagadougou, in order to describe its epidemiological, clinical, and evolutive characteristics. our study included young females who had an onset age of between 35 years and 45 years, residing in ... | 2016 | 27303584 |
| the threat of zika virus in sub-saharan africa - the need to remain vigilant. | 2016 | 27303663 |