Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| mycobacterium avium infection of nasal septum in a diabetic adult: a case report. | mycobacterium avium complex (mac) is primarily a pulmonary pathogen that affects individuals who are immune deficient or immunocompromised. in this report, we describe a very rare case of mac infection clinically presenting as a nasal polyp in a patient with type 2 diabetes mellitus. this case illustrates an atypical anatomic location for mac, the anterior nasal septum in nasal cavity, as well as often overlooked cause of immune compromise, diabetes mellitus. we present the laboratory findings t ... | 2016 | 27325235 |
| relationship between lung cancer and mycobacterium avium complex isolated using bronchoscopy. | the incidence of mycobacterium avium complex (mac)-positive respiratory specimen cultures and mac lung disease (macld) is increasing worldwide. this retrospective study aimed to assess the association between mac culture-positive bronchoscopy specimens and lung cancer. | 2016 | 27335625 |
| increased serum kl-6 levels induced by pulmonary mycobacterium avium complex infection in a patient with ra-associated lung disease. | kl-6 is a glycoprotein found predominantly on type ii pneumocytes and alveolar macrophages, and often shows increased serum levels in patients with interstitial pneumonia. we report a case of mycobacterium avium complex (mac) infection whose disease activity was correlated with kl-6 levels in serum. during treatment of rheumatoid arthritis (ra)-associated interstitial lung disease (ild) with prednisolone, chest image findings improved in association with decreased kl-6 levels. following tapering ... | 2016 | 27339212 |
| lipid nanocarrier-mediated drug delivery system to enhance the oral bioavailability of rifabutin. | rifabutin (rfb) is prescribed for the treatment of tuberculosis infections as well as mycobacterium avium complex (mac) infection in immunocompromised individuals and hiv patients. with a view to develop a sustained release oral solid lipid nanoformulation (sln), rfb was encapsulated in glyceryl monostearate (gms) nanoparticles. the rifabutin solid lipid nanoparticles (rfb-slns), prepared by the solvent diffusion evaporation method, had a size of 345 ± 17.96 nm and pdi of 0.321 ± 0.09. the stabi ... | 2017 | 27350276 |
| analysis of pulmonary non-tuberculous mycobacterial infections after lung transplantation. | non-tuberculous mycobacteria (ntm) are important pathogens in lung transplant recipients. this study describes the spectrum of ntm respiratory tract infections and examines the association of ntm infections with lung transplant complications. | 2016 | 27368989 |
| diagnostic test accuracy of anti-glycopeptidolipid-core iga antibodies for mycobacterium avium complex pulmonary disease: systematic review and meta-analysis. | currently, an anti-glycopeptidolipid (gpl)-core iga antibody assay kit for diagnosing mycobacterium avium complex (mac) is commercially available. we conducted this systematic review and meta-analysis to reveal the precise diagnostic accuracy of anti-gpl-core iga antibodies for mac pulmonary disease (mac-pd). we systematically searched reports that could provide data for both sensitivity and specificity by anti-gpl-core iga antibody for clinically diagnosed mac-pd. diagnostic test accuracy was e ... | 2016 | 27373718 |
| solitary pulmonary nodules due to non-tuberculous mycobacteriosis among 28 resected cases. | in some patients, non-tuberculous mycobacteria (ntm) infections manifest in solitary nodules (solitary nodular [sn] type) generally caused by mycobacterium avium complex (mac). in patients treated using surgical resection, the american thoracic society guidelines state that postoperative chemotherapy is not necessary in the absence of lesions, although there have been a few reports of such cases. | 2016 | 27393550 |
| 18 cases of pulmonary mycobacterium abscessus: clinical difference depending on the presence or absence of mycobacterium avium complex. | it can be difficult to treat respiratory tract infections caused by mycobacterium abscessus (m. abscessus) as there is no established treatment strategy. complications involving other nontuberculous mycobacterial infections such as mycobacterium avium complex (mac) are also commonly observed. | 2016 | 27430867 |
| multiple cavitary pulmonary nodules caused by mycobacterium intracellulare. | nontuberculous mycobacteria (ntm) have been increasingly recognized as an important cause of chronic pulmonary infections. the mycobacterium avium complex (mac), which is composed of two species, mycobacterium avium and mycobacterium intracelluare, is the most commonly encountered pathogen associated with ntm lung disease. mac pulmonary infection typically presents in a fibrocavitary form or a nodular bronchiectatic form. however, there have been atypical presentations of mac pulmonary infection ... | 2016 | 27468344 |
| pulmonary mycobacterium avium infection demonstrating unusual lobar caseous pneumonia. | mycobacterium avium complex (mac) infection is a major medical concern in japan because of its increased prevalence and associated mortality. a common radiological feature in pulmonary mac infection is a mixture of two basic patterns: fibrocavitary and nodular bronchiectatic; however, lobar consolidation is rare. we report an 83-year-old man with lobar caseous pneumonia caused by pulmonary mac infection. radiological findings were predominantly composed of dense lobar consolidation and ground-gl ... | 2016 | 27516892 |
| clinical characteristics, treatment outcomes, and resistance mutations associated with macrolide-resistant mycobacterium avium complex lung disease. | macrolide antibiotics are key components of the multidrug treatment regimen for treating lung disease (ld) due to mycobacterium avium complex (mac). despite the emergence of macrolide resistance, limited data are available on macrolide-resistant mac-ld. this study evaluated the clinical features and treatment outcomes of patients with macrolide-resistant mac-ld and the molecular characteristics of the macrolide-resistant isolates. a retrospective review of the medical records of 34 patients with ... | 2016 | 27572413 |
| antineutrophil cytoplasmic antibody-associated vasculitis superimposed on infection-related glomerulonephritis secondary to pulmonary mycobacterium avium complex infection. | a 73-year-old woman was diagnosed with pulmonary mycobacterium avium complex (mac) infection and received no treatment. disease progression was evident one year later with the development of myeloperoxidase-antineutrophil cytoplasmic antibody (anca) titers and systemic symptoms of a fever, polyarthritis, purpura, and rapidly progressive glomerulonephritis. her symptoms did not improve with antibiotic treatment. a renal biopsy revealed crescentic glomerulonephritis with immunodeposition. accordin ... | 2016 | 27580547 |
| relapse versus reinfection of mycobacterium avium complex pulmonary disease. patient characteristics and macrolide susceptibility. | clinical recurrence of mycobacterium avium complex (mac) pulmonary disease occurs in 10 to 40% of patients treated for this disease process. episodes of clinical recurrence may represent true relapse from the same mac strain or reinfection with a new strain. | 2016 | 27599038 |
| mycobacterium avium complex pulmonary disease: characteristics and treatment in an irish patient cohort. | the prevalence of mycobacterium avium complex (mac) pulmonary disease is increasing globally. however, reliable national and international data relating to its epidemiology and management is lacking. during the period 2003-2014, mac was isolated from the pulmonary samples of 75 patients at the irish mycobacteria reference laboratory (imrl). most patients (42, 56%) had underlying pulmonary disease, and 37 (49%) had clinical/radiographic characteristics consistent with mac pulmonary disease. howev ... | 2016 | 27685490 |
| randomized trial of liposomal amikacin for inhalation in nontuberculous mycobacterial lung disease. | lengthy, multidrug, toxic, and low-efficacy regimens limit management of pulmonary nontuberculous mycobacterial disease. | 2017 | 27748623 |
| environmental nontuberculous mycobacteria in the hawaiian islands. | lung disease caused by nontuberculous mycobacteria (ntm) is an emerging infectious disease of global significance. epidemiologic studies have shown the hawaiian islands have the highest prevalence of ntm lung infections in the united states. however, potential environmental reservoirs and species diversity have not been characterized. in this cross-sectional study, we describe molecular and phylogenetic comparisons of ntm isolated from 172 household plumbing biofilms and soil samples from 62 non ... | 2016 | 27780201 |
| a laboratory-based analysis of nontuberculous mycobacterial lung disease in japan from 2012 to 2013. | since 2010, mycobacterial examination results have been used widely to survey nontuberculous mycobacteria (ntm) lung disease. | 2017 | 27788025 |
| deciphering the virulence factors of the opportunistic pathogen mycobacterium colombiense. | mycobacterium avium complex (mac) contains clinically important nontuberculous mycobacteria worldwide and is the second largest medical complex in the mycobacterium genus after the mycobacterium tuberculosis complex. mac comprises several species that are closely phylogenetically related but diverse regarding their host preference, course of disease, virulence and immune response. in this study we provided immunologic and virulence-related insights into the m. colombiense genome as a model of an ... | 2016 | 27818776 |
| [cutaneous lesions during hot-tub hypersensitivity pneumonitis: pseudomonas folliculitis ?] | interstitial lung disease, cutaneous rash and elevated serum angiotensin converting enzyme (ace) may suggest diagnoses other than sarcoidosis. | 2017 | 27823913 |
| in vitro susceptibility testing of bedaquiline against mycobacterium avium complex. | we performed bedaquiline broth microdilution susceptibility testing using clinical and laboratory standards institute (clsi) guidelines on 103 respiratory isolates of mycobacterium avium complex (mac), including multidrug-resistant isolates. approximately 90% of isolates had bedaquiline mics of ≤0.008 μg/ml, and 102/103 isolates had mics of ≤0.015 μg/ml. bedaquiline has excellent potential for use in patients with mac infections, although for reasons of its metabolism by the cytochrome p450 syst ... | 2017 | 27872065 |
| a case of an enigmatic pulmonary infiltrate. | the differential diagnosis of a pulmonary mass in an immunosuppressed host with a history of cancer is broad and includes malignant, infectious and inflammatory etiologies. mycobacterium avium complex (mac) is a rare cause of opportunistic infection in susceptible individuals that can present as either localized or disseminated disease. on radiologic studies, the pulmonary disease can manifest as heterogeneous linear or nodular densities, a mass-like lesion, or thin-walled cavitary lesions. we p ... | 2016 | 27882275 |
| comparative evaluation of the advansure mycobacteria genoblot assay and the genotype mycobacterium cm/as assay for the identification of non-tuberculous mycobacteria. | in this study, to assess the performance of the advansure mycobacteria genoblot assay (advansure assay), we compared its performance with that of the genotype mycobacterium cm/as assay (genotype assay) for the identification of non-tuberculous mycobacteria (ntm). twenty-four reference strains and 103 consecutive clinical ntm isolates were analysed. the accuracy rates for the 24 reference strains were 87.5 and 95.8 % for the advansure and genotype assays, respectively. for the 103 clinical isolat ... | 2016 | 27902391 |
| dose response models and a quantitative microbial risk assessment framework for the mycobacterium avium complex that account for recent developments in molecular biology, taxonomy, and epidemiology. | mycobacterium avium complex (mac) is a group of environmentally-transmitted pathogens of great public health importance. this group is known to be harbored, amplified, and selected for more human-virulent characteristics by amoeba species in aquatic biofilms. however, a quantitative microbial risk assessment (qmra) has not been performed due to the lack of dose response models resulting from significant heterogeneity within even a single species or subspecies of mac, as well as the range of huma ... | 2017 | 27915187 |
| nontuberculous mycobacteria in cystic fibrosis. | nontuberculous mycobacteria (ntm) are found in approximately 10 % of cystic fibrosis (cf) patients, but only a portion will develop ntm disease. the management of cf lung disease should be optimized, including antibiotic therapy targeted to the individual's usual airway bacteria, prior to considering treatment for ntm lung disease. those who meet criteria for ntm lung disease may not necessarily require treatment and could be monitored expectantly if symptoms and radiographic findings are minima ... | 2016 | 28035194 |
| minimum inhibitory concentration distributions for mycobacterium avium complex-towards evidence-based susceptibility breakpoints. | patients with clinical infections caused by the mycobacterium avium complex (mac) are treated for at least 1 year following sputum conversion with a regimen that suffers from a suboptimal cure rate. the correlation between clinical outcome and drug susceptibility testing breakpoints other than for the macrolides is regarded to be poor. a systematic evaluation of clinical breakpoints for mac has not been performed so far; thus, the aim of this study was to initiate the process by establishing min ... | 2017 | 28069470 |
| primary cutaneous mycobacterium avium complex infection following squamous cell carcinoma excision. | primary cutaneous mycobacterium avium complex (mac) infection is rare, particularly among immunocompetent patients. we present the case of a purportedly healthy patient with primary cutaneous mac infection arising within the excision margins of multiple infiltrating squamous cell carcinomas. | 2016 | 28099547 |
| draft genome sequence of mycobacterium chimaera type strain fl-0169. | we report here the draft genome sequence of the type strain mycobacterium chimaera fl-0169, a member of the mycobacterium avium complex (mac). m. chimaera fl-0169(t) was isolated from a patient in italy and is highly similar to strains of m. chimaera isolated in ireland, although fl-0169(t) possesses unique virulence genes. | 2017 | 28232435 |
| mycobacterium avium infection in portugal. | although the incidence rates of non-tuberculous mycobacteria (ntm) have been increasing in many countries, the basic epidemiology of ntm remains to be fully understood. | 2017 | 28234088 |
| [pulmonary mycobacterium avium-complex (mac) disease differentially diagnosed from metastasis of testicular cancer : a case report]. | a 45 year-old-man was admitted to our hospital because of discomfort in his left scrotum. he had a left testicular tumor. we performed high orchiectomy and pathological findings revealed testicular cancer. he was treated with bleomycin, etoposide and cisplatin. computed tomography showed a new mass in the left lung after 3 cycles of the chemotherapy. because of its rapid growth, the tumor was thought to be a metastasis lesion of testicular cancer or pulmonary infection. transbronchial lung biops ... | 2017 | 28245543 |
| ambiguous presentation of mycobacterium avium complex-associated rasmussen aneurysm. | a 77-year-old man with a progressively dry cough (two months duration) was admitted with hemoptysis. chest computed tomography (ct) revealed left lingular lobe consolidation and one thick-walled cavity lesion over the left lower lobe, which was accompanied by satellite micro-nodules in a tree-in-bud pattern. ct-guided biopsy confirmed mycobacterial infection, and subsequent culture yielded mycobacterium avium complex (mac). unremitting hemoptysis was present despite treatment (14 days) with etha ... | 2017 | 28250929 |
| investigation of mycobacterium avium complex (mac) in australian commercial milk using qpcr. | this technical research communication describes the first study to use quantitative polymerase chain reaction (qpcr) to investigate the presence of mycobacterium avium complex (mac) in australian pasteurised milk. mac is the most common ntm responsible for human illnesses and includes m. avium subspecies paratuberculosis (map). mac is a causative agent of lymphadenitis in children, with contaminated food and water considered as a likely source. as such the presence of mac in milk would have publ ... | 2017 | 28252353 |
| distribution and clinical significance of mycobacterium avium complex species isolated from respiratory specimens. | mycobacterium avium complex (mac) was originally composed of 2 species, m. avium and m. intracellulare. however, several new species closely related to m. intracellulare have recently been identified. in addition, m. avium has been further subdivided into 4 subspecies. the aim of this study was to determine the proportion of different mac species recovered from respiratory specimens and to elucidate the clinical relevance of these species. clinical isolates, from 219 patients, that had been init ... | 2017 | 28291631 |
| infection sources of a common non-tuberculous mycobacterial pathogen, mycobacterium avium complex. | numerous studies have revealed a continuous increase in the worldwide incidence and prevalence of non-tuberculous mycobacteria (ntm) diseases, especially pulmonary mycobacterium avium complex (mac) diseases. although it is not clear why ntm diseases have been increasing, one possibility is an increase of mycobacterial infection sources in the environment. thus, in this review, we focused on the infection sources of pathogenic ntm, especially mac. the environmental niches for mac include water, s ... | 2017 | 28326308 |
| evaluation of the genotype ntm-dr assay for identification of mycobacterium chimaera. | identification of species within the mycobacterium avium complex (mac) is difficult and most current diagnostic laboratory tests cannot distinguish between species included in the complex. differentiation of species within the mac is important as mycobacterium chimaera has recently emerged as major cause of invasive cardiovascular infections following open heart surgery. a new commercial diagnostic assay, genotype ntm-dr ver. 1.0, is intended to differentiate between three species within the mac ... | 2017 | 28356415 |
| changes in serum iga antibody levels against the glycopeptidolipid core antigen during antibiotic treatment of mycobacterium avium complex lung disease. | we evaluated serial changes in the levels of serum immunoglobulin a (iga) antibody to the glycopeptidolipid (gpl) core antigen during antibiotic treatment in 57 patients with m. avium complex (mac) lung disease, at baseline (t0) and after 3 months (t3) and 6 months (t6) of treatment. the median patient age was 59 years and 37 (65%) were female. etiologic organisms included m. avium in 32 (56%) patients and m. intracellulare in 25 (44%). seven (12%) patients had the fibrocavitary form of the dise ... | 2017 | 28367886 |
| long-term outcome of pulmonary resection for nontuberculous mycobacterial pulmonary disease. | pulmonary resection along with multiple antimicrobial therapy has produced favorable outcomes at a few centers. however, little is known regarding the risk factors for long-term survival and microbiological recurrence after pulmonary resection for nontuberculous mycobacterial pulmonary disease (ntmpd). we evaluated the long-term outcomes of pulmonary resection, including microbiological recurrence and survival. | 2017 | 28369361 |
| invasive nontuberculous mycobacterial infections among cardiothoracic surgical patients exposed to heater-cooler devices(1). | invasive nontuberculous mycobacteria (ntm) infections may result from a previously unrecognized source of transmission, heater-cooler devices (hcds) used during cardiac surgery. in july 2015, the pennsylvania department of health notified the centers for disease control and prevention (cdc) about a cluster of ntm infections among cardiothoracic surgical patients at 1 hospital. we conducted a case-control study to identify exposures causing infection, examining 11 case-patients and 48 control-pat ... | 2017 | 28418290 |
| complications of chronic necrotizing pulmonary aspergillosis: review of published case reports. | chronic necrotizing pulmonary aspergillosis (cnpa), a form of chronic pulmonary aspergillosis (cpa), affects immunocompetent or mildly immunocompromised persons with underlying pulmonary disease. these conditions are associated with high morbidity and mortality and often require long-term antifungal treatment. the long-term prognosis for patients with cnpa and the potential complications of cnpa have not been well documented. the aim of this study was to review published papers that report cases ... | 2017 | 28423094 |
| mycobacterium avium complex disease. | despite the ubiqitous nature of mycobacterium avium complex (mac) organisms in the environment, relatively few of those who are infected develop disease. thus, some degree of susceptibility due to either underlying lung disease or immunosuppression is required. the frequency of pulmonary mac disease is increasing in many areas, and the exact reasons are unknown. isolation of mac from a respiratory specimen does not necessarily mean that treatment is required, as the decision to treatment require ... | 2017 | 28429679 |
| clinical features of patients with bacteraemia caused by mycobacterium avium complex species and antimicrobial susceptibility of the isolates at a medical centre in taiwan, 2008-2014. | advanced molecular typing methods have greatly expanded the taxonomy of mycobacterium avium complex (mac) species; however, little is known about the epidemiology and clinical features of bacteraemia caused by different mac species. in this study, the clinical characteristics of patients treated for mac bacteraemia in a tertiary-care centre in northern taiwan during 2008-2014 were investigated. isolates were identified to species level by rpob gene and 16s-23s rrna internal transcribed spacer re ... | 2017 | 28478210 |
| human health risks for legionella and mycobacterium avium complex (mac) from potable and non-potable uses of roof-harvested rainwater. | a quantitative microbial risk assessment (qmra) of opportunistic pathogens legionella pneumophila (lp) and mycobacterium avium complex (mac) was undertaken for various uses of roof-harvested rainwater (rhrw) reported in queensland, australia to identify appropriate usages and guide risk management practices. risks from inhalation of aerosols due to showering, swimming in pools topped up with rhrw, use of a garden hose, car washing, and toilet flushing with rhrw were considered for lp while both ... | 2017 | 28500949 |
| anti-mycobacterium avium complex activity of clarithromycin, rifampin, rifabutin, and ethambutol in combination with adenosine 5'-triphosphate. | we previously reported that adenosine 5'-triphosphate (atp) inhibited the growth of various bacteria, including mycobacteria, staphylococcus, and pseudomonas, without damaging bacterial surface structures. notably, atp's antibacterial activity was found to be attributable to its iron-chelating ability. atp exhibited combined effects with some antimicrobials against mycobacterium intracellulare and methicillin-resistant s. aureus, suggesting its usefulness as an adjunctive drug in the chemotherap ... | 2017 | 28511780 |
| microbiological persistence in patients with mycobacterium avium complex lung disease: the predictors and the impact on radiographic progression. | persistent growth of mycobacterium avium complex (mac) in the lungs indicates continuous infection in mac lung disease (mac-ld), but its clinical significance has not been investigated. we aimed to evaluate the predictors of persistent culture-positivity and its impact on radiographic deterioration in mac-ld. | 2017 | 28541556 |
| incidence of disseminated mycobacterium avium-complex infection in hiv patients receiving antiretroviral therapy with use of mycobacterium avium-complex prophylaxis. | the incidence of disseminated mycobacterium avium complex (mac) infection in hiv patients has fallen markedly since the introduction of effective antiretroviral therapy (art). however, current guidelines still recommend primary prophylaxis. we conducted a retrospective cohort study in a university-affiliated hospital from january 1998 to january 2014. during that period, hiv patients who had at least one cd4 cell count below 50 cells/mm(3) and had been treated with art were enrolled. we compared ... | 2017 | 28592210 |
| development and validation of a prognostic scoring model for mycobacterium avium complex lung disease: an observational cohort study. | patients with mycobacterium avium complex (mac) lung disease (ld) have a heterogeneous prognosis. this study aimed to develop and validate a prognostic scoring model for these patients using independent risk factors for survival. | 2017 | 28629426 |
| disseminated mycobacterium avium complex in an adolescent with perinatally-acquired hiv infection. | mycobacterium avium complex (mac) is the most frequent nontuberculous mycobacteria implicated in opportunistic infections that define acquired immunodeficiency syndrome. with highly active antiretroviral therapy, disseminated mac (dmac) has become a rare entity. this unique case of dmac was diagnosed in an adolescent with newly diagnosed perinatally-acquired hiv infection whose initial cd4 cell count was severely depleted and viral load was extremely high. while maximized treatment regimen had n ... | 2017 | 28663777 |
| a case of bilateral hilar and mediastinal lymphadenopathy developing during treatment for mycobacterium avium complex. | we report a rare case of an immunocompetent patient with mycobacterium avium complex (mac) disease in which bilateral hilar lymphadenopathy developed during anti-mac treatment. this case indicates that propionibacterium acnes would be present and might be a cause of sarcoidosis even in patients with mac. | 2017 | 28680616 |
| characteristics of mycobacterium avium complex (mac) pulmonary disease in previously treated lung cancer patients. | mycobacterium avium complex (mac) is responsible for a large portion of non-tuberculous mycobacterial (ntm) infections worldwide. host factors such as active malignancy, immunosuppression, chronic obstructive pulmonary disease (copd) and bronchiectasis increase the risk of mac infection. however, the relationship between previously treated lung cancer with subsequent development of mac pulmonary disease and treatment outcomes have not been previously studied. | 2017 | 28702340 |
| in vitro activity of aminoglycosides, clofazimine, d-cycloserine and dapsone against 83 mycobacterium avium complex clinical isolates. | treatment success rates for mycobacterium avium complex (mac) diseases range from 50% to 55% only. to explore effective antimicrobials against either mycobacteriumintracellulare or m. avium, we determined in vitro activities of five aminoglycosides, clofazimine, dapsone and d-cycloserine compared with primary (clarithromycin) and secondary (moxifloxacin and linezolid) antimycobacterial agents. | 2017 | 28705770 |
| small bowel obstruction due to mesenteric abscess caused by mycobacterium avium complex in an hiv patient: a case report and literature review. | small bowel obstruction in hiv patients is reportedly caused by inflammatory pseudotumor, kaposi's sarcoma, cryptococcal lymphadenopathy and intestinal tuberculosis. the incidence of mycobacterium avium complex (mac) infection in hiv patients is 3% for cd4 cell count of 100-199 /mm(3). mac causing small bowel obstruction is rarely reported in the literature. we report a rare case of mac causing mesenteric abscess with small bowel obstruction in a hiv patient with a cd4 cell count of 144 /mm(3). ... | 2017 | 28721191 |
| nontuberculous mycobacteria in denmark, incidence and clinical importance during the last quarter-century. | disease caused by nontuberculous mycobacteria (ntm) is reported to increase due to an ageing population and a rise in the proportion of immunosuppressed patients. we did a retrospective cohort study of ntm-disease in the danish population through a quarter-century to determine the disease burden and trends in annual incidence rates. 524,119 clinical specimens were cultured for mycobacteria from 1991 through 2015 at the international reference laboratory of mycobacteriology in denmark. among thes ... | 2017 | 28751677 |
| comparison of methods available for the identification of mycobacterium chimaera. | mycobacterium chimaera is a recently described nontuberculous mycobacterium belonging to the m. avium complex (mac). because this species is implicated in a worldwide outbreak due to contaminated heater-cooler unit water tanks during open-heart surgery, it becomes mandatory for clinical microbiology laboratories to be able to differentiate m. chimaera from the other mac species, especially m. intracellulare. such identification was so far restricted to specialized laboratories, since it required ... | 2017 | 28782649 |
| predictive factors for a one-year improvement in nontuberculous mycobacterial pulmonary disease: an 11-year retrospective and multicenter study. | nontuberculous mycobacterial pulmonary disease (ntm-pd) has become an emerging infectious disease and is responsible for more deaths than tuberculosis in industrialized countries. ntm-pd mortality remains high in some series reportedly ranging from 25% to 40% at five years and often due to unfavorable evolution of ntm-pd despite established treatment. the purpose of our study was to search for early factors that could predict the favorable or unfavorable evolution of ntm-pd at the first year of ... | 2017 | 28787454 |
| mycobacterium avium complex infection and immune reconstitution inflammatory syndrome remain a challenge in the era of effective antiretroviral therapy. | a 10-year review of disseminated mac infection and mac-immune reconstitution inflammatory syndrome (iris) in hiv-positive patients (2004-2014) at a state-wide tertiary referral hiv service, demonstrates that despite advances in antiretroviral therapy, mac infection remains a therapeutic challenge, particularly intra-abdominal disease. | 2017 | 28791872 |
| the efficacy, safety, and feasibility of inhaled amikacin for the treatment of difficult-to-treat non-tuberculous mycobacterial lung diseases. | in multidrug regimens, including an intravenous aminoglycoside (e.g. amikacin [amk]) is recommended for difficult-to-treat non-tuberculous mycobacterial (ntm) lung diseases. we aimed to evaluate the efficacy, safety, and feasibility of inhaled amk therapy in patients with difficult-to-treat ntm lung diseases in a retrospective chart review. | 2017 | 28793869 |
| hsa-mir-346 is a potential serum biomarker of mycobacterium avium complex pulmonary disease activity. | microrna (mirna) has been recently recognized as a biomarker of various diseases; however, there are no known mirnas associated with mycobacterium avium complex (mac) pulmonary disease. in addition, there are no known biomarkers to precisely reflect disease activity after the diagnosis of mac pulmonary disease. thus, we sought to identify a mirna which is a candidate biomarker of mac pulmonary disease activity. serum hsa-mir-346 concentrations of 16 patients with m. avium pulmonary disease were ... | 2017 | 28827075 |
| persimmon-derived tannin has bacteriostatic and anti-inflammatory activity in a murine model of mycobacterium avium complex (mac) disease. | nontuberculous mycobacteria (ntm), including mycobacterium avium complex (mac), cause opportunistic chronic pulmonary infections. notably, mac susceptibility is regulated by various factors, including the host immune system. persimmon (ebenaceae diospyros kaki thunb.) tannin is a condensed tannin composed of a polymer of catechin groups. it is well known that condensed tannins have high antioxidant activity and bacteriostatic properties. however, it is hypothesized that condensed tannins might n ... | 2017 | 28827842 |
| spatio-temporal study of environmental nontuberculous mycobacteria isolated from wardha district in central india. | during the last two decades, nontuberculous mycobacteria (ntm) have gained in importance but there is still a paucity of data, particularly for environmental isolates. we studied, over a period of two years, the spatio-temporal features of ntm isolates obtained from different environmental sources in wardha district, india. a total of 1398 samples (699 each of soil and water) were tested and 170 (12.2%) yielded ntm isolates, including 123 from soil and 47 from water samples. out of 170 ntm isola ... | 2017 | 28836034 |
| distribution of non-tuberculosis mycobacteria strains from suspected tuberculosis patients by heat shock protein 65 pcr-rflp. | the genus mycobacterium contains more than 150 species. non-tuberculosis mycobacteria (ntm) often cause extrapulmonary and pulmonary disease. mycobacteria detection at species level is necessary and provides useful information on epidemiology and facilitates successful treatment of patients. this retrospective study aimed to determine the incidence of the ntm isolates and mycobacterium tuberculosis (mtb) in clinical specimens collected from iranian patients during february 2011-december 2013, by ... | 2017 | 28855835 |
| complete genome sequence of mycobacterium chimaera sj42, a nonoutbreak strain from an immunocompromised patient with pulmonary disease. | mycobacterium chimaera, a nontuberculous mycobacterium (ntm) belonging to the mycobacterium avium complex (mac), is an opportunistic pathogen that can cause respiratory and disseminated disease. we report the complete genome sequence of a strain, sj42, isolated from an immunocompromised male presenting with mac pneumonia, assembled from illumina and oxford nanopore data. | 2017 | 28912319 |
| failure of the azithromycin and ethambutol combination regimen in the hollow-fibre system model of pulmonary mycobacterium avium infection is due to acquired resistance. | to investigate the performance of the two backbone drugs in the standard combination therapy regimen in the hollow-fibre system (hfs) model of pulmonary mycobacterium avium complex (mac) infection. | 2017 | 28922805 |
| linezolid as treatment for pulmonary mycobacterium avium disease. | to identify the pharmacokinetic/pharmacodynamic parameters and exposures of linezolid in the treatment of pulmonary mycobacterium avium complex (mac) disease. | 2017 | 28922806 |
| tedizolid is highly bactericidal in the treatment of pulmonary mycobacterium avium complex disease. | to determine if tedizolid is effective for pulmonary mycobacterium avium complex (mac) disease, and to use pharmacokinetics/pharmacodynamics to design optimal doses. | 2017 | 28922807 |
| the discovery of ceftazidime/avibactam as an anti-mycobacterium avium agent. | to determine if ceftaroline and ceftazidime combined with avibactam are efficacious against pulmonary mycobacterium avium complex (mac) disease. | 2017 | 28922808 |
| a novel ceftazidime/avibactam, rifabutin, tedizolid and moxifloxacin (cartm) regimen for pulmonary mycobacterium avium disease. | to compare the efficacy of ceftazidime/avibactam plus tedizolid-based combination regimens with the standard therapy of azithromycin, ethambutol and rifabutin for the treatment of pulmonary mycobacterium avium complex (mac) disease. | 2017 | 28922809 |
| a programme to create short-course chemotherapy for pulmonary mycobacterium avium disease based on pharmacokinetics/pharmacodynamics and mathematical forecasting. | pulmonary mycobacterium avium complex (mac) prevalence is on the rise worldwide. the average therapy duration is 1.5 years, which is associated with poor cure rates. our objective was to develop a programme to design a combination therapy regimen for pulmonary mac to be administered for 6 months or less with efficacy in > 90% of patients. | 2017 | 28922811 |
| hemophagocytic lymphohistiocytosis (hlh): elusive diagnosis of disseminated mycobacterium avium complex infection. | hemophagocytic lymphohistiocytosis (hlh) is a clinical syndrome of hyperinflammation leading to an uncontrolled and ineffective immune response, associated with high mortality. | 2017 | 28932715 |
| outcomes of mycobacterium avium complex lung disease based on clinical phenotype. | the effect of the clinical phenotype of mycobacterium avium complex (mac) lung disease on treatment outcome and redevelopment of nontuberculous mycobacterial (ntm) lung disease after treatment completion has not been studied systematically.we evaluated 481 treatment-naïve patients with mac lung disease who underwent antibiotic treatment for ≥12 months between january 2002 and december 2013.out of 481 patients, 278 (58%) had noncavitary nodular bronchiectatic (nb) disease, 80 (17%) had cavitary n ... | 2017 | 28954780 |
| natural course of the nodular bronchiectatic form of mycobacterium avium complex lung disease: long-term radiologic change without treatment. | although the incidence of mycobacterium avium complex (mac) lung disease is increasing, the long-term natural course of the nodular bronchiectatic form of mac lung disease is not well described. the objective of our study is to evaluate long-term radiologic changes in untreated mac lung disease by analyzing serial chest computed tomography (ct) scan findings. | 2017 | 28968457 |
| causative species of nontuberculous mycobacterial lung disease and comparative investigation on clinical features of mycobacterium abscessus complex disease: a retrospective analysis for two major hospitals in a subtropical region of japan. | nontuberculous mycobacteria (ntm) lung disease is increasing globally. although the etiological epidemiology of ntm is different across regions, mycobacterium avium complex (mac) is the leading cause of ntm lung disease in most countries, including mainland japan. okinawa is located in the southernmost region of japan and is the only prefecture categorized as a subtropical region in japan, it is therefore likely the etiological epidemiology of ntm lung disease is different from mainland japan. f ... | 2017 | 29059250 |
| disseminated cutaneous infection of mycobacterium colombiense in a patient with myelodysplastic syndrome: a case report. | mycobacterium colombiense (m. colombiense) is a member of the mycobacterium avium complex (mac). to our knowledge, this is the third case report of an m. colombiense infection. an 80-year-old man, immunocompromised by myelodysplastic syndrome (mds), developed a skin rash with exfoliation and eruption on his face and scalp. mycobacteria were detected in pus samples. broad-range polymerase chain reaction (pcr) revealed the mycobacteria to be m. colombiense. the lesions resolved after daily adminis ... | 2017 | 29093379 |
| hot tub lung: a diagnostic challenge. | hot tub lung (htl) is a granulomatous lung disease thought to occur as a result of a hypersensitivity response to non-tuberculous mycobacteria (ntm). typical radiographic findings are diffuse micronodular and/or ground glass opacities. we report an interesting case of htl that presented with unique radiographic features, making its diagnosis a predicament. a 56-year-old immunocompetent female with chronic dyspnea and dry cough was found to have subcentimeter cavitary nodules, predominantly in th ... | 2017 | 29098128 |
| do infections with disseminated mycobacterium avium complex precede sweet's syndrome? a case report and literature review. | sweet's syndrome is reportedly associated with preceding nontuberculous mycobacterial infections (ntmis). here, we report on a systemic mycobacterium intracellulare infection in a patient on corticoid therapy for sweet's syndrome. literature searches show that 69.1% of patients with sweet's syndrome and ntmis developed this syndrome later than ntmis and 89.3% of them developed during the clinical course of a rapidly growing mycobacterial infection. the residual cases were associated with slow-gr ... | 2017 | 29171446 |
| clinical characteristics and treatment outcomes of pleural effusions in patients with nontuberculous mycobacterial disease. | the incidence of nontuberculous mycobacterial (ntm) infection has increased over the last 10 years. however, the clinical characteristics and treatment outcomes of patients with ntm pleuritis have not been well defined. | 2017 | 29173447 |
| cough due to tb and other chronic infections: chest guideline and expert panel report. | cough is common in pulmonary tb and other chronic respiratory infections. identifying features that predict whether pulmonary tb is the cause would help target appropriate individuals for rapid and cost-effective screening, potentially limiting disease progression and preventing transmission to others. | 2017 | 29196066 |
| successful diagnosis of intestinal mycobacterium avium complex infection in a kidney transplant recipient using nasogastric aspirate culture: a case report. | intestinal mycobacterium avium complex (mac) infections are rare and can be challenging to diagnose. we describe a case of intestinal mac infection in a kidney transplant recipient with 5 months of unexplained weight loss and abdominal pain who developed intestinal obstruction. esophagoduodenoscopy with biopsies was performed but was nondiagnostic. intestinal mac was diagnosed via nasogastric aspirate culture results. the patient's symptoms rapidly improved after initiation of appropriate treatm ... | 2017 | 29198678 |
| intermittent antibiotic therapy for recurrent nodular bronchiectatic mycobacterium avium complex lung disease. | intermittent, three-times-weekly oral antibiotic therapy is recommended for the initial treatment of non-cavitary nodular bronchiectatic (nb) mycobacterium avium complex (mac) lung disease. however, intermittent therapy is not recommended for patients who have been previously treated. we evaluated 53 patients with recurrent non-cavitary nb mac lung disease who underwent antibiotic treatment for ≥12 months with daily therapy (n = 26) or intermittent therapy (n = 27) between january 2008 and decem ... | 2017 | 29203483 |
| differences in drug susceptibility pattern between mycobacterium avium and mycobacterium intracellulare isolated in respiratory specimens. | mycobacterium avium complex (mac) is the most common etiologic organisms of nontuberculous mycobacteria (ntm) lung disease. in this study, we aimed to retrospectively investigate the differences in drug susceptibility patterns of two major mac species; mycobacterium avium and mycobacterium intracellulare. a total of 1883 major two mac isolates (1060 m. avium and 823 m. intracellulare) from respiratory specimens were included in this study during the period 2011─2016. the minimum inhibitory conce ... | 2017 | 29223615 |
| impact of chronic pseudomonas aeruginosa infection on health-related quality of life in mycobacterium avium complex lung disease. | in bronchiectasis patients, chronic pseudomonas aeruginosa (pa) infection has been associated with worse health-related quality of life (hrql), but little is known about mycobacterium avium complex lung disease (macld) patients in this context. this study aimed to evaluate hrql and investigate the impact of chronic pa infection in macld patients. | 2017 | 29237500 |
| clinical significance and epidemiologic analyses of mycobacterium avium and mycobacterium intracellulare lung disease from post-marketing surveillance. | in japan, nontuberculous mycobacterial lung disease is mostly attributable to mycobacterium avium complex (mac), i.e., m. avium or m. intracellulare. however, clinical features of the disease caused by these two pathogens have not been studied sufficiently yet. | 2018 | 29325687 |
| mycobacterium avium complex pulmonary disease: new epidemiology and management concepts. | the prevalence of mycobacterium avium complex (mac)-related pulmonary disease has been increasing because of environmental factors, changes in organism virulence, and evolving host susceptibility. treatment is often complicated by adverse effects, development of drug resistance, and refractory disease, with recurrence rates as high as 25-45%. | 2018 | 29346118 |