Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| [eeg mapping during a visuo-spatial task. averaged maps and group statistics]. | twenty young volunteers (10 men, 10 women), righthanded, students, have been recorded in eeg cartography in different situations. we have compared the quantified eegs when the subjects were resting, eyes closed and later, eyes opened, looking at a cartoon. the eegs were quantified by spectral fourier analysis and submitted to data reduction. ten spectral parameters were computed, yielding 51 variables allowing computations and drawings of 90 eeg maps. mean parameters, mean variables, averaged ee ... | 1985 | 4070726 |
| modification of experimental gentamicin nephrotoxicity by selective parathyroidectomy. | dietary calcium loading reduces gentamicin nephrotoxicity in rats. since parathyroid hormone increases renal brush border membrane anionic phospholipids, the putative gentamicin receptors, the effects of selective parathyroidectomy on gentamicin nephrotoxicity were examined. male fisher 344 rats underwent parathyroidectomy or sham surgery. all animals were fed a diet containing 0.5% calcium for 2 wk prior to gentamicin, 20 mg/kg twice daily for 6 and 10 days. other parathyroidectomized rats were ... | 1985 | 4073266 |
| comparison of the energetics of the uncatalyzed and glutamate dehydrogenase catalyzed alpha-imino acid-alpha-amino acid interconversion. | the thermodynamic and activation parameters for the reduction of delta 1-pyrroline-2-carboxylic acid (an alpha-imino acid) by reduced nicotinamide adenine dinucleotide phosphate (nadph) are compared with those for the reduction of the same imino acid by the glutamate dehydrogenase-nadph complex. the enthalpies of activation and standard free energy changes for these two reactions are found to be virtually the same. the catalysis by the enzyme, expressed as the ratio of the reactivity of the enzy ... | 1985 | 4074700 |
| [surgical technics in breast carcinoma. from radical mastectomy to segmental resection--the results of the fisher study]. | 2014 | 4076984 | |
| the haemorheological features of lacunar strokes. | clinical and haemorheological data were recorded in 40 patients with lacunar strokes confirmed clinically and by computed tomography. the following haemorheological variables were monitored: haematocrit, erythrocyte aggregation, erythrocyte deformability, plasma viscosity, fibrinogen concentration and yield shear stress. clinically, most patients had case histories and features according to the description of fisher. all haemorheological parameters with the exception of the haematocrit were path ... | 1985 | 4078601 |
| an all-glass perfusator for investigation of the intestinal transport and metabolism of foreign compounds in vitro. | the in vitro perfusion technique of surviving intestinal segments as described by fisher and parsons (1949) and modified by rummel and stupp (1960) was further improved by the introduction of an all-glass perfusator for studying the intestinal transport and metabolism of lipophilic xenobiotics. | 1985 | 4079445 |
| effect of postoperative radiotherapy on the development of small bowel obstruction in patients undergoing staging laparotomy for hodgkin's disease. | two hundred and ten previously untreated patients with hodgkin's disease underwent staging laparotomy at one institution. medical records of these patients were retrospectively reviewed. the incidence of small bowel obstruction (sbo); whether or not the patient received abdominal radiotherapy and the portals used; whether or not the patient had undergone a previous operation for unrelated disease; and the outcome of operative treatment for the sbo were noted. mean follow-up for all patients was ... | 1985 | 4083264 |
| tyrosine motions in relation to the ferric spin equilibrium of cytochrome p-450cam. | second derivative spectroscopy was used to determine the percentage of tyrosine residues that are exposed to solvent in cytochrome p-450cam isolated from pseudomonas putida. the ratio between two peak to trough second derivative absorbance differences has been shown to be dependent on the polarity of the microenvironment surrounding tyrosine residues [ragone, r., colonana, g., balestrieri, c., servillo, l., & irace, g. (1984) biochemistry 23, 1871]. with a number of camphor analogues that indepe ... | 1985 | 4084552 |
| the herbert differential pitch bone screw in displaced radial head fractures. | the herbert bone screw (herbert and fisher, 1984) has been used in the treatment of ten segmental fractures of the radial head. this differential pitch bone screw provides rigid fixation with compression, has no protruding head, is easily introduced and is of such a small diameter that more than one screw can be used. the early results achieved are reported. | 1985 | 4086103 |
| strain differences and laminar localization of structural neurochemical changes in aging rat. | to obtain comparisons of age-related microchemical changes in cerebral cortex of two commonly employed rat strains (fischer 344 and sprague-dawley), neurochemical assays of substances regarded as quantitative indices of structural entities in brain were performed. these included dna as a marker for cells, lipid sialoganglioside as an index of neuronal membrane mass, and galactocerebroside as an index of myelin. fischer 344 rats were studied at 3-4 months (young), 14-16 months (middle age) and 25 ... | 1985 | 4088423 |
| [cerebral lymphoma associated with lesions of multiple sclerosis]. | a 24 year-old man experienced a left retrobulbar neuritis which improved completely after 2 months of non-steroid antiinflammatory therapy. one month after the end of the treatment he developed a korsakoff-like amnestic syndrome. three months later he complained of horizontal diplopia. a ct scan showed a diffuse enhancement of the periventricular areas, corpus callosum and fornix. diplopia and ct scan abnormalities disappeared after the administration of tetracosactide. subsequently a progressiv ... | 1985 | 4089407 |
| antisperm antibodies and in vitro fertilization failure. | a new enzyme-linked immunosorbent assay (elisa)-based test (zer, jerusalem) has allowed us to show the presence of antisperm antibodies (1:32 to 1:64) in the blood of 14 (33%) of 32 patients undergoing in vitro fertilization and embryo transfer (ivf-et) under gonadotropin stimulation. observation of the morphology of fertilization in eight patients with and seven patients without antisperm antibodies has shown a significant association (p less than or equal to 0.025, fisher exact probability tes ... | 1985 | 4093706 |
| [isolation and study of a strain of fisher lymphadenosis (l-5178) resistant to actinomycin (aurantin)]. | 1973 | 4129063 | |
| evaluation of genetic structure of drosophila melanogaster population with respect to the characteristic radius incompletus. report ii. verification of wright and fisher systems. | 1972 | 4209822 | |
| pseudomonas endocarditis: hemagglutinating antibodies to fisher-devlin-gnabasik immunotypes in sera. | 1974 | 4213766 | |
| fisher hs: not one, but two... | 2014 | 4249198 | |
| application of cell fractionation techniques in the study of cells infected with polyoma virus and newcastle disease virus. | fisher, harold w. (university of rhode island, kingston), hidemi matsumiya, and masanobu azuma. application of cell fractionation techniques in the study of cells infected with polyoma virus and newcastle disease virus. j. bacteriol. 91:1645-1651. 1966.-techniques which permitted rigorous separation of nuclei and cytoplasm were applied to the study of the formation of newcastle disease virus (ndv) in an established line of chinese hamster cells and of polyoma virus (pyv) in mouse embryo fibrobla ... | 1966 | 4286455 |
| transplantation of pituitary "mammotropic" tumor (mtt.f4) from fisher to sprague-dawley rats. | 1966 | 4287660 | |
| [evaluation of functional recombinations of intracellular microstructures using the fisher information index]. | 2007 | 4319357 | |
| dependence of intestinal glucose absorption on sodium, studied with a new arterial infusion technique. | 1. a new preparation of isolated rat jejunum plus ileum (ca. 100 cm) is described in which a saline infusate is pumped into the superior mesenteric artery, the superior mesenteric vein having been ligated.2. the arterial infusate washes out the tissue spaces: the lumen is perfused in a single pass with a segmented flow as by fisher & gardner (1974).3. at an arterial infusion rate of 3 ml./min, steady states are set up in the tissue fluid within 10-15 min: the compositions of the fluids bathing b ... | 1974 | 4422318 |
| the evolutionary advantage of recombination. | the controversy over the evolutionary advantage of recombination initially discovered by fisher and by muller is reviewed. those authors whose models had finite-population effects found an advantage of recombination, and those whose models had infinite populations found none. the advantage of recombination is that it breaks down random linkage disequilibrium generated by genetic drift. hill and robertson found that the average effect of this randomly-generated linkage disequilibrium was to cause ... | 1974 | 4448362 |
| a.r. fisher. | 1973 | 4573311 | |
| what is schistosoma intercalatum fisher, 1934? | 1972 | 4625897 | |
| characterization of a heat-stable protease of pseudomonas fluorescens p26. | a heat-stable, extracellular proteolytic enzyme was isolated from pseudomonas fluorescens p26. brain heart infusion broth (fisher scientific co.), ph 7.5, and incubation at 21 c provided the optimal conditions for bacterial growth for enzyme production. the organism had a d value of 2.6 min at 62.8 c (145 f). the enzyme, however, was quite heat-stable, requiring 15 hr at 62.8 c, 8 hr at 71.4 c, and 9 min at 121 c for complete inactivation. milk, whey, and casein each had a protective effect on t ... | 1973 | 4631436 |
| [comparison of mean values. the behrens-fisher problem]. | 1972 | 4636175 | |
| possibility of in vitro alterations in cultures of mammary carcinoma cells, and altered immunological response in the rat: acquired capacity to reject injections of mammary carcinoma cells and implants of mammary carcinoma. | 1972 | 4672286 | |
| chromatographic adsorption. vi. isomer distribution and mechanism of formation of the methyl glycosides of d-glucose and d-galactose by the fisher method. | 1973 | 4733454 | |
| [fisher-evans disease]. | 1973 | 4738972 | |
| immunotherapy of the dunning leukaemia with thymic extracts. | 1973 | 4759937 | |
| [characteristics of the qualitative composition of the fats of notothenia rossi marmorata fisher]. | 1973 | 4763263 | |
| [fisher-evans syndrome in children]. | 1973 | 4795552 | |
| [mercury in the blood of leisure-fishers who fish in polluted water]. | 1973 | 4797780 | |
| female orgasm: an interview with seymour fisher, ph.d. | 1973 | 4806958 | |
| further studies of crossed and uncrossed pathway responding in callosal agenesis--reply to kinsbourne and fisher. | 1974 | 4842918 | |
| allografts in genetically defined rats: difference in survival between kidney and skin. | although skin allografts from inbred donors of the fisher strain to inbred male lewis recipients regularly show acute rejection within 12 days, orthotopic kidney allografts between untreated animals, in this same combination of strains, usually remain functionally intact for longer than 100 days. since such renal allografts persist despite previous or concomitant rejection of skin allografts, neither acquired tolerance nor nonspecific immunosuppression can explain the surprisingly prolonged kidn ... | 1968 | 4880787 |
| edward j. fisher--new academy president. | 1969 | 4884570 | |
| ronald a. fisher. | 1969 | 4895806 | |
| [the possibility of the application of the alpha-fisher variation index in marine microbiology]. | 2008 | 4906630 | |
| lawrence frederick fisher m.d. 1890-1969. | 1971 | 4926917 | |
| fishers of men: keepers of the aquarium. | 1971 | 4936379 | |
| [ophthalmoplegia, ataxia, and areflexia (fisher-syndrome). a contribution to the polyneuritis cranialis syndrome]. | 1970 | 4994436 | |
| photoreceptor-pigment epithelial cell relationships in rats with inherited retinal degeneration. radioautographic and electron microscope evidence for a dual source of extra lamellar material. | protein synthesis and displacement in photoreceptor and pigment epithelial cells of inbred normal (fisher) and mutant (rcs) rats with inherited retinal degeneration has been studied by light and electron microscope radioautography. groups of animals 14, 15, 17, 19, 27, 35, and 50 days of age were injected with amino acids-h(3) and killed at subsequent time intervals. in normal rats, radioactive protein synthesized in the rod inner segments was incorporated into outer segment saccules and displac ... | 1972 | 5013595 |
| the retirement of sister gibson: occupational health nurse, fisher and paykel ltd, auckland. | 1968 | 5188811 | |
| repair of radiation-induced damage to the cell division mechanism of escherichia coli. | adler, howard i. (oak ridge national laboratory, oak ridge, tenn.), william d. fisher, alice a. hardigree, and george e. stapleton. repair of radiation-induced damage to the cell division mechanism of escherichia coli. j. bacteriol. 91:737-742. 1966.-microscopic observations of irradiated populations of filamentous escherichia coli cells indicated that filaments can be induced to divide by a substance donated by neighboring cells. we have made this observation the basis for a quantitative techni ... | 1966 | 5327364 |
| walter edward fisher. | 1966 | 5329798 | |
| production of staphylococcal enterotoxins a, b, and c in various media. | the effect of initial ph and of length of incubation time at 37 c in four different growth media on the production of staphylococcal enterotoxins a, b, and c was determined. a starting ph of 6.8 gave higher yields of enterotoxins b and c than either ph 6.0 or 5.3. the production of enterotoxin a was, however, not materially affected by the low initial ph of 5.3. prolonged incubation (48 to 72 hr) resulted only occasionally in higher yields of enterotoxin. the effect of the media on the amount of ... | 1969 | 5370657 |
| an evaluation of the fisher hem-alyzer. | the fisher hem-alyzer is a multitest sequential discrete analyser with automatic printout of digitized results on paper tape. the instrument is well designed, soundly constructed, and reliable in routine use. cross contamination from the sampler probe or between the cuvettes is minimal. accuracy and precision are both highly satisfactory. although the standard rate of throughput is 32 specimens per hour the instrument can be used at irregular intervals to analyse smaller batches or even individu ... | 1970 | 5439090 |
| evaluation of the fisher autocytometer. | 1970 | 5474333 | |
| fisher syndrome in childhood. | 1970 | 5490314 | |
| miller-fisher syndrome in a 22-month-old child. | 1970 | 5504080 | |
| a modification of the fisher model 240 or 250 dilutor. | 1970 | 5504613 | |
| anomalies in the position of lower teeth in the fisher, martes pennanti erxl. (mammalia; mustelidae). | 1970 | 5533913 | |
| [apropos of miller fisher syndrome]. | 1971 | 5564031 | |
| a new approach to molecular configuration applied to aqueous pore transport. | a cylindrical treatment of the configuration of small molecules in solution has been proposed. cylindrical dimensions were obtained from fisher-hirschfelder molecular models, and these dimensions were used in an analysis of three sets of reflection coefficient values from the literature. the correlation between solute dimensions and the reflection coefficient was subjected to both statistical analyses and graphical examination, with particular emphasis given to parameter interdependence. the res ... | 1967 | 5584621 |
| [description and use of a modified fisher method for determination of hormonal iodine]. | 2013 | 5600242 | |
| [determination of moisture in folic acid by titration with fisher reagent]. | 2016 | 5611966 | |
| a note on the fisher-parsons surface area formula in the light of mucosal fresh and dry weights of rat small intestine. | 1968 | 5655253 | |
| magnesium sulfate interactions in seawater from solubility measurements. | the extent of association between magnesium and sulfate ions was determined in artificial seawater by a solubility technique. about 10 percent of the magnesium ions were found to be associated. this result supersedes the earlier value found in this laboratory and agrees with the results of garrels and thompson, thompson, and fisher. | 1968 | 5664507 |
| [content of bruneomycin in solid tumors and ascites of albino mice with transplanted sarcoma crocker and lymphadenosis (strain l-5178 fisher)]. | 1968 | 5678104 | |
| fisher, wright, and path coefficients. | 1968 | 5686301 | |
| method for the determination of unsaturated iron-binding capacity of serum using radioactive iron and magnesium carbonate. | a method for measuring the unsaturated iron-binding capacity of serum using radioactive iron with magnesium carbonate as the adsorbing substance is described. the radioactive iron-magnesium carbonate method, compared with the methods of caraway (1963), herbert, gottlieb, lau, fisher, grevirtz, and wasserman (1966), and bothwell, jacobs, and kamener (1959), was shorter and simpler and equally reproducible. | 1968 | 5697051 |
| fisher syndrome of ophthalmoplegia, ataxia and areflexia. (an unusual variant of acute idiopathic polyneuritis). | 2009 | 5715319 | |
| moisture determination in crude drugs by the karl fisher method. | 1968 | 5734376 | |
| [on the association of autoimmune thrombocytopenic purpura with autoimmune hemolytic anemia in children (fisher-evans syndrome)]. | 1968 | 5753368 | |
| [total bilateral ophthalmoplegia. manifestation of the miller-fisher syndrome]. | 1968 | 5757940 | |
| miller fisher syndrome (variant of landryguillainbarrestrohl syndrome--ophthalmoplegia, ataxia, areflexia). | 1966 | 5903354 | |
| neuromuscular mechanisms of burrow irrigation in the echiuroid worm urechis caupo fisher & macginitie. i. anatomy of the neuromuscular system and activity of intact animals. | 1966 | 5971998 | |
| neuromuscular mechanisms of burrow irrigation in the echiuroid worm urechis caupo fisher & macginitie. ii. neuromuscular activity of dissected preparations. | 1966 | 5971999 | |
| an evaluation of the variance of leukocyte counts as performed with the hemocytometer, coulter, and fisher intruments. | 1966 | 5981660 | |
| [on simultaneously occurring thrombocytopenia and an acquired hemolytic anemia. a contribution to the fisher-evans syndrome]. | 1966 | 5984509 | |
| chronic inhalation of diesel exhaust and coal dust: effect of age and exposure on selected enzyme activities associated with microsomal cytochrome p-450 in rat lung and liver. | male fisher-344 rats were exposed by inhalation to low levels of diesel exhaust and coal dust, alone or in combination, or to filtered air, 7 h/d, 5 d/wk for 24 mo. cytochrome p-450-associated benzo[a]pyrene hydroxylase and 7-ethoxycoumarin deethylase activities were assayed in lung and liver microsomes after 3, 6, and 24 mo. age-related changes in enzyme activities were observed, but they were not altered by the exposures. when the data were adjusted for age, only one difference was observed. l ... | 1984 | 6084065 |
| simian virus 40 illegitimate recombination occurs near short direct repeats. | we have analysed nucleotide sequences at the junction between simian virus 40 (sv40) and cellular dna in the fisher rat transformed line tsa30-n2. this line contains a single insertion of one complete sv40 genome with a terminal duplication of 267 nucleotides, the recombination sites being located at nucleotides 439 and 705 in the late region of sv40. these two positions are located within short direct repeats in the virus genome. in order to test the significance of such repeats with respect to ... | 1984 | 6086940 |
| a single rat fibronectin gene generates three different mrnas by alternative splicing of a complex exon. | three fibronectin mrnas exist in rat liver, differing by the presence or absence of segments of 285 or 360 bases at a point within the coding region. we previously proposed that the three mrnas are encoded by a single gene and arise via alternative splicing of a common transcript. in order to test this hypothesis, we have isolated clones spanning approximately half of the fibronectin gene from a fisher rat genomic library; blot hybridization analyses reveal the presence of only one fibronectin g ... | 1984 | 6089177 |
| enhanced ouabain sensitivity of the heart and myocardial sodium pump in aged rats. | tolerance to arrhythmogenic actions of digitalis decreases with advanced age. to determine if aged myocardium has reduced glycoside tolerance, ouabain sensitivity and associated biochemical changes were examined in young (3-month), adult (8-month) and aged (26-month old) fisher 344 rats, because age-related changes in physiology and biochemistry are well characterized in this strain of rats. although rats are uniquely tolerant to digitalis, basic mechanisms leading to inotropic and toxic actions ... | 1984 | 6092116 |
| less than 40% of the simian virus 40 large t-antigen-coding sequence is required for transformation. | f8dl is a simian virus 40 early-region deletion mutant that lacks the simian virus 40 dna sequences between 0.168 and 0.424 map units. despite this large deletion, cloned f8dl dna transforms fisher rat f111 cells and balb/3t3 clone a31 mouse cells as efficiently as does cloned simian virus 40 wild-type dna. these results indicate that less than 40% of the large t-antigen-coding sequence is required for efficient transformation. | 1984 | 6092929 |
| site of synthesis of the alpha and beta subunits of the na,k-atpase in brine shrimp nauplii. | developing nauplii (embryos) of the brine shrimp artemia salina are an excellent model system for studying the biogenesis of the sodium- and potassium-activated adenosine triphosphatase (na,k-atpase). the nauplii exhibit a burst of na,k-atpase synthesis between 6 and 32 h of development (peterson, g. l., churchill, l., fisher, j. a., and hokin, l. e. (1982) j. exp. zool. 221, 295-308). we have now determined the sites of synthesis of the alpha and beta subunits of the na,k-atpase in developing a ... | 1984 | 6094544 |
| differences in phosphorylation of the two large subunits of brine shrimp na,k-atpase. | analysis of purified na,k-atpase from brine shrimp nauplii revealed two molecular forms of the alpha subunit separable by sodium dodecyl sulfate-polyacrylamide gel electrophoresis [g.l. peterson, r.d. ewing, s.r. hootman, and f.p. conte (1978) j. biol. chem. 253:4762]. the molecular form with lower mobility is designated alpha 1 and the one with higher mobility, alpha 2, in a neutral or alkaline gel system. differences in na+-dependent, k+-sensitive phosphorylation of these two molecular forms h ... | 1984 | 6094698 |
| characterization of the cholinergic stimulation of phosphoinositide hydrolysis in rat brain slices. | the stimulation of the formation of inositol phosphates by various cholinergic agonists and antagonists was studied in rat brain cortical slices. incubation of the slices with [3h]inositol led to the incorporation of radioactivity into inositol lipids. the accumulation of inositol phosphates was then followed in the presence of 8 mm lithium which blocks the hydrolysis of inositol phosphate. the release of inositol phosphate was linear up to 15 min when stimulated by 1 mm carbachol. acetylcholine ... | 1984 | 6094748 |
| [metastatic properties of rat fr 3t3 cells, transformed by polyomavirus in the fisher rat]. | 1984 | 6098323 | |
| effects of n,n'-dicyclohexylcarbodiimide and n-(ethoxycarbonyl)-2-ethoxy-1,2-dihydroquinoline on hydride ion transfer and proton translocation activities of mitochondrial nicotinamidenucleotide transhydrogenase. | n,n'-dicyclohexylcarbodiimide (dccd) inhibits the mitochondrial energy-linked nicotinamidenucleotide transhydrogenase (th). our studies [phelps, d.c., & hatefi, y. (1981) j. biol. chem. 256, 8217-8221; phelps, d.c., & hatefi, y. (1984) biochemistry 23, 4475-4480] suggested that the inhibition site of dccd is near the nad(h) binding site, because nad(h) and competitive inhibitors protected th against inhibition by dccd and, unlike the unmodified th, the dccd-modified th did not bind to nad-agaros ... | 1984 | 6099137 |
| rescue of silent integrated polyoma genomes suggests homologous recombination between resident and transfected dna fragments. | two defective polyoma virus genomes, deleted in the nucleotide sequences coding the n-termini of the tumor antigens, were introduced into fisher 3t3 rat cells by dna-mediated gene transfer (transfection). the resulting integrated genomes were incapable of conferring a transformed phenotype to the cells. however, after transfection of these lines with small polyoma fragments overlapping the deleted sequences, transformed clones were isolated. these clones were analyzed by southern genomic blot hy ... | 1984 | 6100071 |
| effect of magnesium deficiency on erythrocyte aging in rats. | rats placed on a magnesium-deficient diet show decreased erythrocyte magnesium concentration, shortened erythrocyte survival, and erythrocyte membrane ultrastructure defects and become progressively anemic. whether these pathologic processes are due to abnormal erythropoiesis or occur in the peripheral circulation is unknown. in the present study, magnesium and hemoglobin concentrations, reticulocyte count, erythrocyte pyrophosphatase, and pyruvate kinase activities were determined at weekly int ... | 1980 | 6106388 |
| enzymatic and ultrastructural study of lysosomes in rats bearing radiation-induced thyroid follicular carcinoma. | radiation-induced well-differentiated and poorly differentiated follicular thyroid cancers were transplanted into the intrascapular fat pads of male fisher 144 rats. the tumors grew in the recipient rats and after a time interval were removed and studied along with normal rat thyroids for lysosomal activity and ultrastructural characteristics. plasma from experimental and control rats was also studied for lysosomal activity. rats with radiation-induced thyroid carcinoma had a decrease in growth ... | 1981 | 6109795 |
| propagation of korean hemorrhagic fever virus in laboratory rats. | korean hemorrhagic fever virus (khfv) has been adapted to the wistar and fisher strains of rats. infection was detected by the appearance of specific antigen in the lung tissue of the infected rats at 14 to 64 days after inoculation and by the appearance of circulating antibodies in ther serum which reacted specifically with khfv antigen in the lungs of infected apodemus agrarius subsp. coreae 3 weeks after inoculation. distribution of antigen in rat tissues as determined by immunofluorescent st ... | 1981 | 6111538 |
| age-related changes in dopamine, lhrh and somatostatin in the rat hypothalamus. | the distribution of dopamine, somatostatin and lhrh was examined in young and aged male rats of the fisher 344 strain. dopamine histofluorescence and peptide immunocytochemical staining were performed together in each animal by the use of a stimultaneous visualization technique. comparative analysis or rats at 3, 12, 20, and 30 months of age revealed a general decrease in somatostatin and lhrh in the median eminence; dopamine fluorescence intensity also was depressed in the median eminence altho ... | 1980 | 6115324 |
| histochemistry of nadh diaphorase and gamma-glutamyltranspeptidase in rat bladder tumors. | to improve identification of preneoplastic bladder cancer cells, we have studied two enzyme histochemical changes in bladder tumors induced in male fisher 344 rats by the carcinogen n-butyl-n-(4-hydroxybutyl)-nitrosamine. in early areas of focal nodular hyperplasia there was a dramatic increase in staining for nadh:menadione oxidoreductase (diaphorase)activity. in nonfocal areas as well, there were many individual cells with intense staining, while the controls were of uniform moderate staining. ... | 1982 | 6124324 |
| diazepam disposition in mature and aged rabbits and rats. | the disposition of diazepam after intravenous administration was investigated in mature young and old female dutch belted rabbits (1-1.5 and 5.6.5 years) and fischer-344 rats (6 and 30 months) to determine whether they exhibited an age-related increase in distribution similar to that previously observed in the human. no significant differences were found in the pharmacokinetic behavior of diazepam or its n,-demethylated metabolite between the young and old rabbits, although there was a suggestio ... | 1982 | 6126343 |
| a 174-kilodalton atpase/datpase polypeptide and a glycoprotein of apparently identical molecular weight are common but distinct components of higher eukaryotic nuclear structural protein subfractions. | a 174-kilodalton polypeptide of the drosophila nuclear matrix-pore complex-lamina fraction has been identified as an atpase/datpase on the basis of direct uv photoaffinity labeling studies; a polypeptide with similar properties has been found in nuclear envelope fractions prepared from several vertebrate sources (berrios, m., blobel, g., and fisher, p. a. (1983) j. biol. chem. 258, 4548-4555). this atpase/datpase polypeptide co-migrates on sodium dodecyl sulfate (sds)-polyacrylamide gels with a ... | 1983 | 6138358 |
| effects of cimetidine and ranitidine on halothane metabolism and hepatotoxicity in an animal model. | this study was undertaken to determine the effects of two h2-receptor antagonists, cimetidine and ranitidine, on halothane metabolism and hepatotoxicity in the hypoxic fisher 344 rat model for halothane hepatitis. in this model, liver injury is caused by toxic intermediates formed during metabolism of halothane by a reductive pathway. administration of cimetidine (120 mg/kg ip) 20 min prior to anesthesia led to inhibition of the reductive pathway, as assessed by measurement of the exhaled metabo ... | 1984 | 6141900 |
| age-dependent alterations in synaptic membrane systems for ca2+ regulation. | the effects of aging on two neuronal plasma membrane ca2+ regulating systems have been examined using synaptic membranes isolated from the brains of adult (5-7-month-old) and aged (23-25-month-old) fisher 344 rats. the kinetic characteristics of the na+-dependent ca2+ transport system were found to be altered in the aged animals. the affinity of the transport carrier for ca2+ was decreased in membranes from aged animals, with very little change in the maximal transport capacity of the system. th ... | 1984 | 6144821 |
| effect of acetaminophen toxicity on erythrocyte osmotic fragility in the fisher rat. | the protective effect of propylthiouracil (ptu) pretreatment against acetaminophen-induced erythrocyte osmotic fragility was determined in the male fisher rat. hepatotoxicity was assessed for comparative purposes. ptu (0.15%) was fed in chow for a period of 12 days. acetaminophen (1 g/kg body wt) was then administered orally by a stomach tube after an overnight fast. the rats were killed either 4 or 24 hr later. erythrocyte osmotic fragility was determined by the extent of hemolysis in various c ... | 1984 | 6149873 |
| control of growth of estrogen-sensitive cells: role for alpha-fetoprotein. | the role played by alpha-fetoprotein (afp) during the perinatal period in rats has not yet been ascertained despite earlier suggestions that this plasma protein affected the multiplication, in an "in animal-in culture" system of tumor cells that are stimulated by estrogen (e) for growth. to test this inference developed from our previous work, afp was purified by reverse affinity chromatography to homogeneity by electrophoretic and immunochemical criteria. purified afp was added at different con ... | 1980 | 6154944 |
| collagen lysyl oxidase activity in the lung increases during bleomycin-induced lung fibrosis. | intratracheal administration of bleomycin caused pulmonary fibrosis in rats. bleomycin sulfate (640 micro grams/165 g b.wt. in 0.5 ml of sterile saline) was instilled intratracheally into male fisher 344 rats (169 +/- 5 g), whereas control animals received 0.5 ml of sterile saline by the same route. one, 3, 7, 14, 28 and 322 days after instillation, the animals were killed, the lungs were homogenized in 6 m urea, 0.01 m nacl, 0.001 m potassium phosphate (ph 8.3) and the homogenates were subjecte ... | 1981 | 6170751 |
| [cell-free pseudomonas vaccine. iii. immunochemical analysis of purified pseudomonas aeruginosa protein antigens and protective properties of antisera against these antigens]. | the immunochemical analysis of isolated and purified antigens a and b obtained from p. aeruginosa, strains 868 (serogroup o3 according to lányi or immunotype 3/7 according to fisher) and 170015 (serogroup o7 or immunotype 2), was carried out. rabbit antisera to proteins a and b, as well as to the initial aqueous extracts and partially purified aqueous extracts, were obtained. cross activity between the protein antigens of different strains was established by the methods of immunodiffusion and tw ... | 1983 | 6188300 |
| repeated pulmonary function evaluation following bleomycin treatment. | a computerized, nonsurgical, pulmonary function measurement method was tested for sensitivity and utility in detecting the development of fibrosis. bleomycin, a fibrogenic agent, was intratracheally instilled into male fisher 344 rats. respiratory function was monitored in restrained, awake animals before treatment and for the subsequent 4 wk. in the first week, among responders, a significant (p less than 0.05) drop in body weight, tidal volume, and compliance was accompanied by a significant i ... | 1983 | 6188851 |
| cytokeratin and nonhistone protein antigenic changes in rat liver during azo dye but not hepatotoxin feeding. | chromosomal proteins from rat liver have been assessed immunologically for changes in specific cytokeratins or primary tumor nonhistone proteins during treatment with an azo dye hepatocarcinogen (3'-methyl-4-dimethylaminoazobenzene), (3'-me-dab) or the hepatotoxin alpha-naphthyl-iso-thiocyanate (alpha-nit). fisher rats were fed laboratory diets supplemented with either agent and sacrificed sequentially at various intervals. chromosomal proteins from these livers were electrophoresed in the prese ... | 1983 | 6190586 |
| abnormal phagolysosome fusion in pulmonary alveolar macrophages of rats exposed chronically to cigarette smoke. | cigarette smoking is strongly associated with functional and morphologic changes in pulmonary alveolar macrophages (pam). phagocytic activity is a primary function of pam, and although the ingestion of particles appears to be normal in the pam of cigarette smokers, published data suggest that antimicrobial activity of these cells might be diminished. because phagolysosome fusion (plf) is an important aspect of the phagocytic process subsequent to the ingestion phase, plf was evaluated in pam lav ... | 1984 | 6206755 |
| susceptibility to adjuvant arthritis in da and f344 rats. a dominant trait controlled by an autosomal gene locus linked to the major histocompatibility complex. | the hereditary of adjuvant-induced arthritis in rats of the da and fisher 344 strains was examined. development of arthritic lesions in response to a single injection of supplemented freund's complete adjuvant has been found to be controlled by an autosomal, dominant gene locus, ar. the capacity to respond was present in da rats and absent in our fisher rats. ar has been found to be linked to the major histocompatibility complex genes with which it exhibits a high rate of recombination. | 1982 | 6215923 |
| induction of prostaglandin synthesis-dependent suppressor cells with endotoxin: occurrence in patients with thermal injuries. | the induction of lymphocyte suppressor activity with bacterial endotoxin is well documented. while most of the evidence has been obtained using animal models and has required large doses of endotoxin, we have demonstrated that additions of as little as 1.0 ng of chromatographically purified endotoxin [from escherichia coli 055:b5, e. coli 0111:b4, pseudomonas aeruginosa (fisher-devlin immunotype 1), serratia marcescens, or salmonella minnesota] to human mixed lymphocyte or to mitogen-stimulated ... | 1983 | 6222063 |
| imino proton assignments in the proton nuclear magnetic resonance spectrum of the lambda phage or3 deoxyribonucleic acid fragment. | the 17 base pair duplex d(tatcaccgcaagggatap) . d(tatcccttgcggtgatap) corresponding to the or3 operator site of lambda phage has been synthesized and studied by 1h nuclear magnetic resonance spectroscopy at 470 mhz. the 13 imino proton resonances observed at 20 degrees c have been assigned to specific base pairs at positions 3-15 on the basis of nuclear overhauser effect measurements and studies of the temperature dependence of peak intensities. resonances from the a-t base pairs at positions 1, ... | 1983 | 6226312 |