Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| [role of viruses in cardiac pathology]. | 1974 | 4365756 | |
| studies on the replicase of encephalomyocarditis virus. | 1974 | 4366015 | |
| increased sensitivity of cell-free protein synthesis to double-stranded rna after interferon treatment. | 1974 | 4366491 | |
| the mechanism of viral replication. structure of replication complexes of encephalomyocarditis virus. | the structure of the purified replicative intermediate of encephalomyocarditis virus was determined by electron microscopy. approximately 80% of the replicative intermediate complexes were characterized by a filament of double-stranded rna of widely variable length, which had a "bush" of single-stranded rna at one end. in many examples one or more additional single-stranded bushes were appended internally to the double-stranded rna filament. these results support the view that before deproteiniz ... | 1974 | 4366773 |
| inactivation of some bacterial and animal viruses by exposure to liquid-air interfaces. | 1974 | 4367307 | |
| bis-basic-substituted polycyclic aromatic compounds. a new class of antiviral agents. 2. tilorone and related bis-basic ethers of fluorenone, fluorenol, and fluorene. | 1974 | 4367593 | |
| bis-basic-substituted polycyclic aromatic compounds. a new class of antiviral agents. 3. 2,7-bis(aminoacyl)fluorenes and -fluorenones. | 1974 | 4367594 | |
| bis-basic-substituted polycyclic aromatic compounds. a new class of antiviral agents. 4. bis-basic sulfonamides of anthraquinone. | 1974 | 4367595 | |
| glucose intolerance in mice infected with encephalomyocarditis virus. | 1974 | 4367721 | |
| cleavage of mengovirus polyproteins in vivo. | the synthesis of mengovirus-specific proteins in vivo was studied by labeling the viral proteins with radioactive amino acids under conditions in which host protein synthesis was almost completely inhibited. pulse-chase experiments enabled the kinetic analysis of the cleavages of certain viral protein precursors and the formation of others. the pattern of cleavages of mengovirus precursor polypeptides is similar to that of encephalomyocarditis virus. the major difference between the two viruses ... | 1974 | 4367902 |
| characterization of the large picornaviral polypeptides produced in the presence of zinc ion. | zinc ion inhibits the posttranslational cleavages of human rhinovirus-1a, encephalomyocarditis virus, and poliovirus polypeptides. each virus displayed a different susceptibility to zinc. however, in each case the cleavages of the capsid precursor and the cleavages analogous to the c --> d --> e conversion in encephalomyocarditis virus were most sensitive to zinc. higher concentrations of zinc resulted in the buildup of even larger precursor polypeptides of a size between 106,000 and 214,000 dal ... | 1974 | 4367904 |
| [etiology of encephalomyocarditis in rhesus monkeys]. | 1974 | 4368130 | |
| encephalomyocarditis virus infection of mouse plasmacytoma cells. i. inhibition of cellular protein synthesis. | mouse plasmacytoma ascites tumor cells (mopc 460) were efficiently infected with encephalomyocarditis virus. inhibition of host protein synthesis was evident after 2 h and complete by 4 h postinfection. the mechanism by which virus infection results in inhibition of host cell protein synthesis was studied in vitro. cell-free protein-synthesizing systems, prepared from uninfected and infected cells, were found to be equally active with respect to their abilities to translate cellular and viral mr ... | 1974 | 4368674 |
| encephalomyocarditis virus infection of mouse plasmacytoma cells. ii. effect on host rna synthesis and rna polymerases. | the effect of encephalomyocarditis virus infection of mopc 460 mouse plasmacytoma cells on host rna synthesis and rna polymerases was investigated. consistent with work performed in other virus host systems, rates of rna synthesis appeared to be inhibited in infected cells, whereas rna degradation appeared normal. these results were further extended with isolated nuclei, in which distinct rna polymerase activities could be studied under conditions where problems with rna turnover and endogenous ... | 1974 | 4368675 |
| in vitro synthesis of structural proteins of semliki forest virus directed by isolated 26 s rna from infected cells. | 1974 | 4368800 | |
| the synthesis of encephalomyocarditis virus polypeptides in infected l-cells and cell-free systems. | 1974 | 4369366 | |
| virus-specific proteins associated with ribosomes of krebs-ii cells infected with encephalomyocarditis virus. | 1974 | 4369440 | |
| [effect of a selective inhibitor of ribosomal rna synthesis on the antiviral action of interferon]. | 1974 | 4369543 | |
| bis-basic-substituted polycyclic aromatic compounds. a new class of antiviral agents. 1,2 6. bis-basic-substituted fluoranthenes. | 1974 | 4369817 | |
| bis-basic-substituted polycyclic aromatic compounds. a new class of antiviral agents. 5. bis-basic ethers of anthraquinone and bisalkamine esters of anthraquinonedicarboxylic acids. | 1974 | 4369818 | |
| experimental encephalomyocarditis virus infection of pigs. | 1974 | 4370016 | |
| inhibition of interferon action by plant lectins. | 1974 | 4370104 | |
| replication of arboviruses in mouse organ cultures. i. results with middelburg virus in organ cultures and peritoneal macrophages. | 1974 | 4370336 | |
| selective inhibition of the synthesis of single-stranded rna of encephalomyocarditis virus by 2-(alpha-hydroxybenzyl)-benzimidazole in cell-free systems. | 1974 | 4370357 | |
| the synthesis of virus-specific polypeptides on polyribosomes isolated from the cells infected with encephalomyocarditis virus. | 1974 | 4370505 | |
| characteristic ultrastructural changes in organs of newborn mice infected with emc virus. | 1974 | 4370623 | |
| virologic studies of multiple sclerosis and other chronic and relapsing neurological diseases. | 1974 | 4371203 | |
| pronounced antiviral activity of human interferon on bovine and porcine cells. | 1974 | 4371444 | |
| interferon inducers in therapy of infection with encephalomyocarditis virus in mice. i. effect of single doses of polyriboinosinic-polyribocytidylic acid and tilorone hydrochloride on viral pathogenesis. | 1974 | 4371528 | |
| interferon inducers in therapy of infection with encephalomyocarditis virus in mice. ii. effect of multiple doses of polyriboinosinic-polyribocytidylic acid on viral pathogenesis. | 1974 | 4371529 | |
| adaptation of influenza virus to growth in cultured murine methylcholanthrene induced tumors. | 1974 | 4371624 | |
| influence of immunosuppressive drugs on replication of col mm virus and productive of interferon in vivo. | 1974 | 4371712 | |
| the anti-virus activity of double-stranded rna in the presence of antibody to double-stranded rna. | 1974 | 4372061 | |
| interferon-sepharose: priming of l cells for induction of interferon by mm virus. | 1974 | 4372309 | |
| poly(c) in animal viral rnas. | 1974 | 4372534 | |
| binding of interferon to gangliosides. | 1974 | 4372547 | |
| induction of interferon in mice by mycoplasmas. | interferon was induced in mice after intraperitoneal inoculation with four different mycoplasmas. peak levels of between 100 and 300 u of interferon per ml were attained by 6 h postinfection with each of the mycoplasmas except mycoplasma arthritidis, which induced higher titers (400 to 11,800 u/ml) by this time. a fifth mycoplasma, m. pulmonis, induced interferon inconsistently and at a later (72 to 96 h) time. mycoplasmatales virus mvl51 and sterile mycoplasmal broth did not stimulate interfero ... | 1974 | 4373395 |
| hyporeactivity due to infection: recognition of a transferable hyporeactive factor in the serum of encephalomyocarditis virus-infected mice. | as previously reported, mice infected with encephalomyocarditis (emc) virus progressively develop a state of hyporeactivity to interferon induction as evidenced by an 80% reduction in serum interferon levels produced in response to four different inducers administered 96 h after initiation of infection. in the current report, this hyporesponsiveness was further documented in vitro in peritoneal exudate cells harvested at the time of maximal hyporeactivity (96 h) during emc virus infection. these ... | 1974 | 4373396 |
| renaturation of inactivated interferons by "defensive reversible denaturation". | 1974 | 4373700 | |
| encephalomyocarditis (emc) virus infection of the femoral artery of newborn mice. | 1974 | 4373746 | |
| mode of action and biological properties of insoluble interferon. | 1974 | 4373752 | |
| [stability of cytoplasmic poly-(a)-containing rnas in cells infected with encephalomyocarditis virus]. | 1974 | 4374345 | |
| a high-molecular-weight protein component required for natural messenger translation in ascites tumor cells. | 1974 | 4375033 | |
| viral myocarditis in animals. | 1974 | 4375411 | |
| efficiency of translation of viral and cellular mrna's in extracts from cells infected with encephalomyocarditis virus. | the relative efficiency of translation of host cell mrna and encephalomyocarditis (emc) virus rna has been investigated in cell-free preparations from uninfected and emc virus-infected drebs-ii cells. the ability of cell-free extracts from infected cells to translate exogenously-added emc virus rna and total krebs-ii cell mrna was markedly diminished, but no evidence for the selective inhibition of translation of host cell mrna in these systems was obtained. | 1974 | 4376807 |
| [the antiviral properties of corynebacterium parvum]. | 1974 | 4376977 | |
| viruses in experimental and human diabetes. | 1974 | 4377456 | |
| competition between eukaryotic messenger rnas in cell-free protein synthesis. | 1974 | 4377720 | |
| interferon bioassay methods and the development of standard procedures: a critique and analysis of current observations. | 1974 | 4377882 | |
| peculiarities of virus multiplication in explants and monolayer cell cultures from immune mouse organs. | 1965 | 4379437 | |
| the role of interferon in tick-borne encephalitis virus-infected l cells. iv. origin of insusceptibility of persistently infected l cells to the action of exogenous interferon. | 1965 | 4379466 | |
| insusceptibility of cell cultures to the action of exogenous interferon as the result of virus infection of the cells. | 1966 | 4380469 | |
| activity of salicylates as inhibitors of virus replication in vitro and their mode of action. | 1966 | 4381329 | |
| effect of multiplicity of infection on the rate of protein synthesis in encephalomyocarditis virus-infected l cells. | 1967 | 4382471 | |
| peculiarities of the antiviral action of dibenzylphosphinic acid. | 1967 | 4382472 | |
| an interferon like substance induced by mannans. | 1967 | 4382481 | |
| effect of a space cabin environment on viral infection. | 1967 | 4383045 | |
| the temperature requirement for interferon production in cells stimulated by newcastle disease virus or microbial agents in vitro. | 1967 | 4383884 | |
| production of interferon-like inhibitor in chickens after secondary induction by bacteria and virus. | 1968 | 4385157 | |
| potentiation of the antiviral activity of interferon by histones. | 1968 | 4386015 | |
| induction of interferon activity in mouse serum by phase i coxiella burneti antigen. | 1968 | 4386026 | |
| inactivation of single- and double-stranded ribonucleic acid of encephalomyocarditis virus by ultraviolet light. | 1968 | 4387327 | |
| release of an interferon-like virus inhibitor during contact of mouse leukocytes with target cells. | 1970 | 4392852 | |
| [formation of interferon in the brain of baby mice after injection with some rhabdoviruses]. | 1969 | 4393905 | |
| effects of phenylalanine analogues on virus multiplication and protein synthesis in a cell-free system. | 1971 | 4397338 | |
| relation of incubation temperature to interferon production in mouse peritoneal cells infected with newcastle disease virus. | 1969 | 4398703 | |
| release of interferon by mouse peritoneal cells in vitro. the requirement of contact with endotoxin and the temperature dependence of release. | 1969 | 4398704 | |
| interaction between encephalomyocarditis (emc) virus and polio-virus in cultured cells. increase in the number of emc virus-producing cells. | 1972 | 4401077 | |
| effect of cyclophosphamide on the protective action of endotoxin in mice challenged with encephalomyocarditis virus. | 1972 | 4402249 | |
| enhancement of interferon production by lowered temperature and-or cyclohexximide in endotoxin-stimulated mouse leukocytes. | 1972 | 4402251 | |
| distribution of antiviral and cell-inhibitory activity in interferon preparations. | 1972 | 4403180 | |
| effect of nembutal on uninfected and encephalomyocarditis virus-infected krebs-ii carcinoma cells. | 1972 | 4404100 | |
| evaluation of the czechoslovak double-stranded rna preparation as inducer of interferon in model experiments. | 1972 | 4404898 | |
| viral infection and resistance in immunosuppressed host. ii. stimulatory effect and morphology following a single injection of an interferon inducer of the double-stranded rna type. | 1973 | 4405392 | |
| [synthesis of virus-specific proteins in cells infected by the encephalomyocarditis virus]. | 1971 | 5103259 | |
| protection against herpes virus and encephalomyocarditis virus encephalitis with a double-stranded rna inducer of interferon. | 1970 | 5414254 | |
| the effect of liposomal charge on the neutralizing antibody response against inactivated encephalomyocarditis and semliki forest viruses. | the primary neutralizing antibody response to encephalomyocarditis (emc) virus and semliki forest virus (sfv) is enhanced by addition of either negatively or positively charged liposomes. the purified u.v. light inactivated viruses were merely mixed with liposomes and injected intraperitoneally (i.p.) into mice. in contrast, neutral liposomes were unable to enhance the primary response to these viruses. furthermore primary immunization with inactivated sfv mixed with either neutral, positively o ... | 1984 | 6086188 |
| activation of the ppp(a2'p)na system in interferon-treated, herpes simplex virus-infected cells and evidence for novel inhibitors of the ppp(a2'p)na-dependent rnase. | high doses (100-1000 reference units/ml) of alpha or beta interferons are required to inhibit the growth of herpes simplex virus types i and ii (hsv-i and hsv-ii) in human chang cells. in contrast, much lower doses (10-100 reference units/ml) of interferon inhibit replication of encephalomyocarditis virus (emcv) in these cells. in the hsv-infected cells these high doses did not prevent the virus-induced shut off of host protein synthesis. the interferons were more effective in reducing the virus ... | 1984 | 6088228 |
| antiviral activity of lambda-, beta-, and gamma-interferons in the presence of theophylline: involvement of 2',5'-oligo(a) synthetase. | theophylline, an inhibitor of camp phosphodiesterase, induces in human ovary carcinoma cells (caov) a 2-2.5-fold elevation of intracellular camp. this rise in the camp level is followed by an increase of the activity of 2',5'-oligo(a) synthetase in caov cells -insignificant (1.5-fold) after 16 hr incubation, and substantial (3.7-fold) after 30 hr incubation, as well as the development of antiviral resistance. once caov cells have been incubated with the mixtures containing theophylline (2 mm) an ... | 1984 | 6089814 |
| pppa2'p5a' blocks vesicular stomatitis virus replication in intact cells. | pppa2'p5'a blocked the production of infectious vesicular stomatitis virus in hela cells. when this compound was present from the beginning of infection, a selective inhibitory effect was observed in viral protein synthesis. thus, cellular translation was not affected even after 10 h of incubation with this compound, and the bulk of viral proteins was not synthesized. however, this effect was not observed with atp, gtp, or the core a2'p5'a. the step blocked by pppa2'p5'a is located early during ... | 1984 | 6090695 |
| the importance of immunologic factors in the pathogenesis of encephalomyocarditis virus induced diabetes in mice. | the pathogenesis of emc virus induced diabetes has generally been thought to be caused by direct cytopathic effect of the virus on beta cells with susceptibility or resistance dictated primarily by the density of viral receptors on the beta cells of different individuals. the histological finding of insulitis, our demonstration of a protective effect of immunosuppression with als or anti-theta antibody and silica supports host immune factors as important determinants of susceptibility. a critica ... | 1984 | 6091611 |
| the emc-virus induced insulitis . a sign of autoimmunity. | 1984 | 6091613 | |
| [nucleotide sequence of the 3'-terminus of encephalomyocarditis virus rna]. | reverse transcription produced dna-copies of the 3'-terminal sequence of mouse encephalomyocarditis virus rna. cloning and sequencing of this cdna afforded the structure of the 3'-terminus of viral rna over the length of 2988 nucleotide residues. the probable sites of proteolytic cleavage of the immature protein have been determined and the homology with the respective poliovirus proteins has been established. | 1984 | 6091680 |
| [heterogeneity of the poly(c) tract of encephalomyocarditis virus rna]. | the nucleotide sequence of the rnase t1-resistant fragment of encephalomyocarditis virus rna that includes the poly(c) tract was determined by gel sequencing and mobility shift methods. this sequence is (5') ac126(127) ucucucuc9uaacg (3'). the results show that the poly(c) tract is discontinuous, i.e., it is interrupted by the ucucucu-sequence. the tract displays anomalously high mobility in polyacrylamide gels as compared to random polynucleotides, indicating that electrophoretic determination ... | 1983 | 6091690 |
| [the nucleotide sequence of the 3'-terminal region of encephalomyocarditis virus rna]. | reverse transcription afforded dna-copies of the 3'-terminal sequence of mouse encephalomyocarditis virus rna. cloning of this cdna in pbr 322 plasmid and sequencing of dna of one of the clones established the structure (552 nucleotide residues) of the 3'-terminus of viral rna. this region contains a non-translatable fragment (126 nucleotides) and also the fragment coding for the c-terminus of viral replicase. | 1983 | 6091696 |
| encephalomyocarditis virus replication complexes preferentially utilizing nucleoside diphosphates as substrates for viral rna synthesis. nucleotide kinases specifically associated with the complex channel rna precursor. | replication complexes (rc) of the encephalomyocarditis (emc) virus were shown previously to contain components that exhibit marked preference for nucleoside diphosphates over nucleoside triphosphates (ntp) as substrates for viral rna synthesis [koonin and agol (1983), virology 129, 309-318]. these ndp-preferring components have now been found to posses the following properties. when rc preparations were fractionated by sucrose density gradient centrifugation, the fractions containing ndp-preferr ... | 1984 | 6092069 |
| activity of human recombinant and lymphoblastoid interferons in human and heterologous cell lines. | three human alpha interferon (huifn-alpha) preparations currently being used in clinical trials, rifn-alpha a, rifn-alpha 2, and lymphoblastoid ifn (lym-ifn) had appreciable activity against encephalomyocarditis and vesicular stomatitis viruses (vsv) in guinea pig transformed and guinea pig embryo cells, but not mouse l or rabbit kidney cells. the level of activity in guinea pig cells, compared with human wish cells, was 182% (range 9%-1,900%). these results suggest that the guinea pig may be us ... | 1984 | 6094683 |
| encephalomyocarditis virus rna synthesis in vitro is protein-primed. | a crude membrane-bound replication complex isolated from encephalomyocarditis virus-infected cells is able to initiate the synthesis of viral rna. both the formation of the primer, vpg-pu, and its utilization for the initiation of rna chains take place in this system. a significant amount of the synthesized vpg-pu is found in the free form. the predominant product of the de novo initiation is represented by short phenol-soluble vpg oligonucleotide species, and only a small percentage of the latt ... | 1984 | 6096134 |
| the protection of coenzyme q10 against experimental viral myocarditis in mice. | we studied the effects of coenzyme q10 (coq10) on dba/2 mice inoculated with the m variant of encephalomyocarditis virus. the mice were treated as follows: 1) coq group (n = 49); coq10 1.0 mg (0.1 ml) x 2/day (0.1 mg/g/day), 2) control group (n = 55); sham-liquid 0.1 ml x 2/day. these treatments were intraperitoneally performed every day on days -1 to 12. in both groups, we determined the heart and serum contents of coq9 and coq10, which are the biologically active forms of coq in mice, in the m ... | 1984 | 6096581 |
| different ph requirements for entry of the two picornaviruses, human rhinovirus 2 and murine encephalomyocarditis virus. | the entry into cells of human rhinovirus 2 (hrv 2) and murine encephalomyocarditis (emc) virus was studied by the use of light-sensitive virus grown in the presence of acridine orange (hrv 2) and neutral red (emc). hela cells were protected against infection with hrv 2 by nh4cl, monensin, and other compounds known to increase the ph of intracellular vesicles. preincubation of the cells with the same compounds reduced the ability of the cells to bind [35s]methionine-labeled hrv 2, apparently due ... | 1984 | 6097029 |
| [action of human leukocyte and immune interferons on the reproduction and cytopathogenic effect of the encephalomyocarditis virus in mice]. | a comparative study of the antiviral effect of human immune and leukocyte interferons in homologous diploid cells showed that the resistant condition of the cells produced by interferon depended on the type and concentration of the inhibitor, its presence in the culture medium and time of action on the cells. reproduction of emc virus and its cytopathic effect were inhibited to a much greater extent when the cells were treated with leukocyte interferon. the resistance of the cells in both cases ... | 1984 | 6097046 |
| a radioimmunologic technique to screen for antibodies to alpha-2 interferon. | a radioimmunologic technique has been developed to screen sera of persons receiving human alpha-2 interferon for the presence of specific antibodies to alpha-2 interferon. the method is sensitive and easy to perform. it tests the ability of the sera to neutralize alpha-2 interferon and prevent the interferon from being detected by an immunoradiometric assay. the results obtained using this technique are in good agreement with an anti-viral, cytopathic effect assay. using the immunological techni ... | 1984 | 6097611 |
| disparate response of encephalomyocarditis virus and mm virus to interferon in jls-v9r cells. | jls-v9r cells, a balb/c mouse bone marrow cell line chronically infected with rauscher leukemia virus, were treated with mouse interferon and inoculated with several different lytic viruses. relatively low interferon concentrations protected the cells against sindbis virus, vesicular stomatitis virus and mm virus. in contrast, encephalomyocarditis virus replication was inhibited by less than 1 log even with an interferon concentration of 1000 u/ml. these findings provide further evidence that in ... | 1984 | 6099710 |
| a highly efficient method of cell infection with encephalomyocarditis virus rna. | a method for infecting krebs-ii cells with encephalomyocarditis virus rna based on treatment of the cells with deae-dextran at high concentration was elaborated. the specific infectivity of virion rna was 3 x 10(8) plaque-forming units per microgram, i. e. comparable to the specific infectivity of the whole virus. a high proportion of the cell population could be infected by this method. | 1980 | 6106373 |
| type i and type ii interferons: differential antiviral actions in transformed cells. | in transformed mouse embryo cells, type ii interferon had much less antiviral activity than type i interferon. in non-transformed cells, the two interferons had similar high activity, reversal of the phenotype of moloney sarcoma virus (msv) transformed cells by sodium butyrate restored their sensitivity to the antiviral action of type ii interferon. additional evidence for a role of the cytoskeletal network in the action of type ii interferon is that its antiviral effect is reduced by cytochalas ... | 1980 | 6155431 |
| on the mechanism of single-stranded rna synthesis by encephalomyocarditis virus replication complexes: preferential inhibition by adenylyl (beta, gamma-methylene)-diphosphonate. | 1980 | 6156090 | |
| 2'5' oligo(a) polymerase activity in serum of mice infected with emc virus or treated with interferon. | interferon-treated cells show an increase in two double-stranded rna (dsrna)-dependent enzymatic activities involving an oligoadenylate polymerase and a protein kinase (ref. 1 and refs therein). the polymerase converts atp into a series of oligonucleotides characterized by 2'5'-phosphodiester bonds, designated 2'5'-oligo(a) or 2-5a (ref. 1). these oligonucleotides activate an endoribonuclease that degrades rna in extracts of control and interferon-treated cells. these observations have been made ... | 1980 | 6157092 |
| [antiviral activity of murine interferons produced by bacterial and animal cell translation of messenger rna]. | interferon was produced by e. coli bacteria and animal cell messenger-rna--interferon translation (mrna--if). the activity of the interferon produced by simultaneous mrna--if translation in these two cellular systems was, approximately, similar. the interferons translated by bacteria and animal cells inhibited the cytopathic effect, reproduction and plaque-formation of vesicular stomatitis virus, and, to a greater extent, of mouse encephalomyocarditis virus. the virus titration was carried out b ... | 1980 | 6158177 |
| emulsifiers that enhance susceptibility to virus infection: increased virus penetration and reduced interferon response. | an emulsifier which had an environmental relationship to reye's syndrome, when used to treated l-929 cultures, was shown to increase the rate of encephalomyocarditis virus penetration and uncoating while having no effect on the attachment of virus or on the replication of infectious ribonucleic acid. this treatment also rendered l-929 cells unable to respond normally to interferon inducers and reversed an already established interferon antiviral state. it is proposed that one or more of these ac ... | 1980 | 6158915 |
| human leukocyte interferon produced by e. coli is biologically active. | a human leukocyte interferon cdna was enzymatically synthesized, inserted into the vector pbr322, and cloned in escherichia coli. the dna sequence codes for a 23-amino acid signal peptide followed by an interferon polypeptide of 165 amino acids. an expression plasmid was constructed which permits the synthesis in e. coli of 2.5 x 10(8) units of interferon per litre of culture. this leif protected squirrel monkeys from lethal encephalomyocarditis virus infection. | 1980 | 6159538 |