Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| cell production gradients in the developing ferret isocortex. | the accumulation of cells within the cortical plate was studied in ferrets at two developmental ages. a survey method based on the presumed radial organisation of cortical neuron production was used to sample variations in cell production along the rostrocaudal and laterodorsal axes of the brain. the resulting cell counts confirmed the presence of a gradient of cortical plate formation, with a rostrolateral focus. these findings were discussed in relation to some recent teratological studies on ... | 1986 | 3693037 |
| gyrus formation in the cerebral cortex in the ferret. i. description of the external changes. | the external features of gyrus formation in the postnatal ferret cerebral cortex are described and correlated with certain internal changes. the observations indicate that gyri are formed by longitudinal and radial expansion of the cortical compartment occurring between relatively fixed areas which form the sulcal floors. the gyri were initially rounded with open sulci and the cerebrum had a rectangular outline when seen in lateral and dorsal view. by adult life the hemisphere had been subjected ... | 1986 | 3693054 |
| gyrus formation in the cerebral cortex of the ferret. ii. description of the internal histological changes. | the internal changes within a developing gyrus of the ferret cerebral cortex were studied by recording (i) the changing length and direction of the radial tissue lines and (ii) the emergence of the tangential banding of the classical six cortical layers. together these lines provided a coordinate net whose deformations during development gave an indication of the differential growth occurring within a gyrus. the changes in these features suggested that a gyrus was initiated by an area of local g ... | 1986 | 3693076 |
| patterns of blood supply to the gastric mucosa. a comparative study revealing an end-artery model. | the form of the gastric arterial supply to the mucosa has been studied in dog, swine, ferret, cat, guinea-pig, rabbit and rhesus monkey. in all these species, the bore of vessels in the submucous plexus diminished from body to pylorus, though this was most marked in the guinea-pig and rabbit. the plexus was also continuous across the pylorus with duodenal vessels. thus the well known poverty of vascularity in distal parts of the human stomach is shared by other species and is unlikely to be a co ... | 1986 | 3693108 |
| changing glial organization relates to changing fiber order in the developing optic nerve of ferrets. | the structures of the developing eye-stalk and the relationships of early retinofugal fibers as they pass through the stalk, chiasm, and tract have been studied by light and electron microscopical methods in fetal ferrets aged 23-27 days. the early eye-stalk can be divided into two parts: a narrow extracranial part has a narrow lumen and is lined by few cells, whereas a thicker intracranial part has a wider lumen and is lined by several rows of cells. at the earliest stages no axon bundles are r ... | 1987 | 3693606 |
| early uncrossed component of the developing optic nerve with a short extracerebral course: a light and electron microscopic study of fetal ferrets. | during the study of the developing optic nerve described in the preceding paper (guillery and walsh, '87), small bundles of nerve fibers were seen passing between the optic nerve and the ipsilateral hypothalamus of 24-to 27-day-old prenatal ferrets. the bundles appear before any other fiber groups of the retinofugal pathway and are identifiable while the main portions of the retinofugal system are growing into the optic tracts. the bundles, made up of 50 or more axons, leave the optic nerve, eme ... | 1987 | 3693607 |
| maximal ca2+-activated force and myofilament ca2+ sensitivity in intact mammalian hearts. differential effects of inorganic phosphate and hydrogen ions. | myofilament ca2+ sensitivity and maximal ca2+-activated force are fundamental properties of the contractile proteins in the heart. although these properties can be evaluated directly in skinned preparations, they have remained elusive in intact tissue. a novel approach is described that allows maximal ca2+-activated force to be measured and myofilament ca2+ sensitivity to be deduced from isovolumic pressure in intact perfused ferret hearts. phosphorus nuclear magnetic resonance spectra are obtai ... | 1987 | 3694173 |
| transport of dimethylamine, a precursor of nitrosodimethylamine, into stomach of ferret and dog. | dimethylamine is important because it is a precursor of nitrosodimethylamine, a suspected carcinogen in man. significant quantities of dimethylamine and nitrite are found in gastric fluid, and conditions in the stomach are favorable for nitrosodimethylamine formation. little is known about the origins of dimethylamine in gastric fluid. studies were performed to determine whether dimethylamine can be transported from blood to gastric fluid. there was no diurnal variation of the dimethylamine cont ... | 1986 | 3698205 |
| the architecture of nerves and ganglia of the ferret trachea as revealed by acetylcholinesterase histochemistry. | the goal of this study was to determine the architecture of the nerves and ganglia of the ferret trachea. tracheas from four newborn ferrets and three adult ferrets were stained histochemically for acetylcholinesterase activity and analyzed in their entirety as whole mounts. the architecture consisted of one or two longitudinal nerve trunks overlying the posterior surface of the trachealis muscle, a dense plexus of nerves superficial to the trachealis muscle that interconnected these longitudina ... | 1986 | 3700726 |
| dirofilariasis in a ferret. | an adult male ferret was found to be lethargic and dyspneic. necropsy revealed 21 worms in the heart, vena cava, and pulmonary artery. the worms were identified as dirofilaria immitis. histologic examination of lung tissue revealed numerous microfilariae. | 1986 | 3710876 |
| age-related fiber order in the ferret's optic nerve and optic chiasm. | although the mammalian optic tract shows a grouping of fibers by age, with newer fibers nearer the pial surface, the possible rules for fiber ordering in the mammalian optic nerve have not been well defined. in this study, preferential labeling of the older retinal fibers in the ferret, a close relative of the cat, shows that the age-related fiber order in the ferret's optic tract reflects a systematic sorting of fibers by age that occurs in the optic nerve, and that is maintained through the op ... | 1986 | 3712001 |
| a comparison of two different indicators: quin 2 and aequorin in isolated single cells and intact strips of ferret portal vein. | a comparison between the fluorescent indicator quin 2 and the bioluminescent indicator aequorin was performed in the same smooth muscle cell type. aequorin was loaded into intact strips and quin was loaded into enzymatically isolated single cells from ferret portal vein. both indicators gave qualitatively the same calcium profiles when the tissue was challenged with agonists. quin loading caused a dramatic shift to the right in dose response curves to potassium and phenylephrine. the ed50 values ... | 1986 | 3714445 |
| changes in granule cells of the ferret olfactory bulb associated with imprinting on prey odours. | the maturation of the granule cells of the ferret olfactory bulb around the time of odour imprinting has been examined. rapid golgi impregnation studies revealed a temporal overshoot in the development of the spines on the external and internal dendrites of the granule cells. in contrast, the number of somatic spines decreased continuously. electron microscopical examinations of the synaptic contacts in the external plexiform layer revealed that the time course of synapse and reciprocal synapse ... | 1986 | 3719301 |
| ferrets as pets. | 1986 | 3721957 | |
| evidence for a non-cholinergic excitatory innervation in the control of colonic motility. | the colon of the ferret anesthetized with urethane exhibits two distinct types of motility patterns. these were abolished or considerably reduced by blocking nervous conduction in the vagus nerves by cooling to below 4 degrees c. atropine transiently abolished motility which on its return was also found to be sensitive to vagal integrity. electrical stimulation of either the cut central or peripheral end of a branch of the abdominal vagus caused large amplitude contractions of the colon which we ... | 1986 | 3729625 |
| pulsatile release of luteinizing hormone and testosterone in male ferrets. | the temporal organization of lh and testosterone secretion was examined in male european ferrets. hormone levels were measured in frequent blood samples taken via an indwelling jugular cannula from sexually mature and castrated ferrets. intact ferrets discharge lh and testosterone in discrete pulses, but the frequency and amplitude of these pulses vary within and between individual males. the average frequency of lh pulses was 1.14 +/- 0.25 pulses/h, with an amplitude of 1.59 +/- 0.23 ng/ml in 1 ... | 1986 | 3732162 |
| k+-induced alterations in airway muscle responsiveness to electrical field stimulation. | we investigated possible pre- and postsynaptic effects of k+-induced depolarization on ferret tracheal smooth muscle (tsm) responsiveness to cholinergic stimulation. to assess electromechanical activity, cell membrane potential (em) and tension (tm) were simultaneously recorded in buffer containing 6, 12, 18, or 24 mm k+ before and after electrical field stimulation (efs) or exogenous acetylcholine (ach). in 6 mm k+, em was -58.1 +/- 1.0 mv (mean +/- se). in 12 mm k+, em was depolarized to -52.3 ... | 1986 | 3733628 |
| effect of prenatal exposure to aromatase inhibitor, testosterone, or antiandrogen on the development of feminine sexual behavior in ferrets of both sexes. | experiments were conducted to assess the role of prenatal exposure of the brain to estrogen in controlling the development of proceptive and receptive feminine sexual behavior in ferrets of both sexes. female ferrets, deprived prenatally of estrogen via maternal ovariectomy on gestational day 30 (42-day gestation) plus sc implantation of an aromatase inhibitor, 1,4,6-androstatriene-3,17-dione (atd), into their mothers, were significantly less receptive than control females when tested in adultho ... | 1986 | 3737708 |
| sexual differentiation of play behavior in the ferret. | three experiments were performed to elucidate the endocrine mechanisms responsible for sex differences in the prepubertal play behavior of ferrets. in experiment 1, gonadally intact adolescent males exhibited higher levels of "stand-over" behavior than females did in tests between 63 and 123 days of age with gonadally intact female partners of the same age. in experiment 2, ferrets exposed to androgen or to ovarian steroids over days 5-20 of postnatal life subsequently exhibited significantly hi ... | 1986 | 3741607 |
| inhibition of cisplatin-induced vomiting by selective 5-hydroxytryptamine m-receptor antagonism. | mdl 72222, the selective 5-hydroxytryptamine (5-ht) m-receptor antagonist, prevented or reduced cisplatin-induced emesis in ferrets. it is suggested that cisplatin-induced, and possibly other cytotoxic drug-induced vomiting may involve a 5-ht m-receptor mechanism. | 1986 | 3742146 |
| annual rhythm and hormonal control of predatory behavior in female ferrets. | the predatory behavior of female ferrets shows seasonal fluctuations which appear to be affected by estradiol. under natural lighting conditions in the laboratory the annual rhythm of the behavior was observed during anestrus, estrus, pregnancy, pseudopregnancy and lactating period. females in heat failed to show predatory behavior whereas females in anestrus killed their prey. exposure of anestrous ferrets to a prolonged illumination (ld 16:8) during winter induced an estrus which inhibited pre ... | 1986 | 3749320 |
| neonatal exposure of female ferrets to testosterone alters sociosexual preferences in adulthood. | sociosexual preferences in adult female ferrets, as measured in a choice arena, were altered by neonatal exposure to exogenous testosterone. adult female ferrets showed a preference for males which did not depend on the presence of gonadal steroids, because gonadectomized and gonadectomized estrogen-treated females showed identical preferences for males. adult castrated males showed no preference for females unless these males were treated with testosterone. a similar no-preference pattern was f ... | 1986 | 3749401 |
| antibody and cellular immune responses to microfilarial antigens in ferrets experimentally infected with brugia malayi. | eleven of 15 ferrets experimentally infected with brugia malayi became amicrofilaremic after a brief patency; only four ferrets remained patent after 6 months of infection and two of these ferrets developed a high, persistent microfilaremia. blastogenic responses of peripheral blood lymphocytes to antigens of microfilariae (mf), assayed in vitro, demonstrated an antigen sensitivity at prepatent, patent and postpatent periods of infection. lymphocytes from ferrets with high microfilaremia had ele ... | 1986 | 3751232 |
| cold-adapted reassortants of influenza a virus: pathogenicity of a/ann arbor/6/60 x a/alaska/6/77 reassortant viruses in vivo and in vitro. | cold-adapted reassortants of a/ann arbor/6/60 x a/alaska/6/77 viruses made in mdck cells have recently been assessed genotypically and for temperature-sensitive and cold-adapted phenotypes. these reassortants were used to infect ferrets and hamsters and to inoculate organ cultures of hamster tracheal rings, in order to assess their degree of virulence. virulence in the three model systems corresponded quite well, and a correlation between loss of virulence and particular a/aa/6/60 genes present ... | 1986 | 3753204 |
| ion transport across cat and ferret tracheal epithelia. | sheets of trachea from ferret and cat were mounted in ussing chambers and continuously short circuited. under resting conditions, in both the cat and ferret there was little or no cl secretion, and na absorption accounted for most of the short-circuit current (isc). ouabain (10(-4) m, serosal bath) reduced isc to zero in 30-60 min. this decline was matched by a decrease in net na absorption. amiloride (10(-4) m, luminal bath) caused a significant decrease in isc and conductance (g) in both speci ... | 1986 | 3759745 |
| the direct negative inotropic effect of gossypol. | gossypol, an effective male antifertility agent, had a minor but significant negative inotropic action in isolated ferret right ventricular papillary muscles at concentrations of 1-5 micrograms/ml. reduction of peak developed force and maximum extent of shortening was readily demonstrable at three different resting control contractile states achieved through increases in extracellular calcium from 0.625 to 2.5 mm/l. gossypol had no significant effect on maximum rate of tension rise nor on maximu ... | 1986 | 3762194 |
| internal potassium activity in ferret ventricular muscle. | measurements of the k activity (aik) in ferret ventricle were made using either single- or double-barrelled k-sensitive micro-electrodes. aik was also estimated from the nernst equation by measuring the membrane potential when changing the external k concentration. micro-electrodes filled with the corning k sensor gave unreliable results most probably due to interference from some substance(s) in the heart cells. reproduceable measurements were obtained using a valinomycin cocktail as the k sens ... | 1986 | 3763807 |
| free intracellular magnesium concentration in ferret ventricular muscle measured with ion selective micro-electrodes. | the free mg concentration ([mg]i) was measured in ferret ventricular muscle using single-barrelled mg-sensitive micro-electrodes. the electrodes were calibrated in solutions containing the [k]i and [na]i measured in this tissue. in thirteen measurements from seven experiments conforming to strict criteria for calibration and penetration the estimated mean [mg]i was 0.4 mmol/l. this is to be regarded as an upper limit since it was estimated by linear extrapolation of the calibration curve. | 1986 | 3763808 |
| molecular studies of the differential replication at pyrexial temperatures of two influenza viruses differing in virulence for ferrets. | replication of a virulent clone (7a) of the reassortant influenza virus a/puerto rico/8/34-a/england/939/69 (h3n2) in ferret nasal turbinate tissue is less affected than that of an attenuated clone (64d) by temperatures which occur during pyrexia in ferrets. this is a factor which contributes to the difference in virulence of the two clones. the differential replication of the two clones at pyrexial temperatures has been reproduced in allantois-on-shell (egg-bit) cultures, and the synthesis of v ... | 1986 | 3765825 |
| representation of the cochlea in primary auditory cortex of the ferret (mustela putorius). | in seven barbiturate-anesthetized ferrets, we explored the acoustically sensitive cortex with conventional microelectrode mapping techniques. a tonotopically organized field was found whose orientation was such that high tonal frequencies were represented dorsally, and low frequencies ventrally. within this field, neurons typically had short (12-20 ms) latent periods to first spikes. in conjunction with extant anatomical evidence on the connectivity of this region, these data suggest that this f ... | 1986 | 3771373 |
| mechanisms of arrhythmogenic delayed and early afterdepolarizations in ferret ventricular muscle. | drug-induced triggered arrhythmias in heart muscle involve oscillations of membrane potential known as delayed or early afterdepolarizations (dads or eads). we examined the mechanism of dads and eads in ferret ventricular muscle. membrane potential, tension and aequorin luminescence were measured during exposure to elevated [ca2+]0, strophanthidin and/or isoproterenol (to induce dads), or cesium chloride (to induce eads). ryanodine (10(-9)-10(-6) m), an inhibitor of ca2+ release from the sarcopl ... | 1986 | 3771791 |
| virus contamination and cytopathology of ferret tracheal epithelial cells in culture caused by vaccination with distemper virus. | 1986 | 3773467 | |
| 5-hydroxytryptamine m-receptor antagonism to prevent cisplatin-induced emesis. | the administration to the ferret of cisplatin, 10mg/kg (i.v.), caused an intense emetic response that was prevented by ics 205-930 (0.1 and 1.0 mg/kg i.v.) and metoclopramide (4.0 mg/kg i.v.). smaller doses of ics 205-930 (0.01 mg/kg i.v.) and metoclopramide (2.0 mg/kg i.v.) attenuated the emetic response to cisplatin. it is concluded that the potent action of ics 205-930 against cisplatin-induced emesis is the consequence of a 5-hydroxytryptamine m-receptor antagonism which may also contribute ... | 1986 | 3774121 |
| the effects of locally applied capsaicin on conduction in cutaneous nerves in four mammalian species. | by examination of compound action potentials in the saphenous nerve of the anaesthetized rat it has been shown that capsaicin causes a rapid, dose-dependent, failure of conduction in many c-fibres when applied directly to the nerve. a large reduction in c-fibre conduction occurs with concentrations as low as 110 microm. after a 15-30 min exposure to capsaicin, only partial recovery occurs in 1 h. similar block of c-fibre conduction occurs in the ferret. however, only smaller, reversible, reducti ... | 1986 | 3779210 |
| basal n-nitrosoproline formation and excretion in the ferret. | quantitative balance studies indicated that ferrets (mustela putorius furo) on purified diets excreted approximately four times more n-nitrosoproline than they ingested. this basal n-nitrosoproline excretion was not dependent on dietary nitrate intake, as high levels of dietary [15n]nitrate did not result in the incorporation of 15n into the excreted n-nitrosoproline. this indicates that there are at least two sources of endogenous n-nitrosoproline formation, one linked to dietary nitrate and on ... | 1986 | 3781434 |
| concealed positive force-frequency relationships in rat and mouse cardiac muscle revealed by ryanodine. | increases in stimulation frequency between 0.3 and 2 hz decrease developed tension in rat, seemingly inconsistent with the explanation that an elevation of intracellular na+-ion concentration is responsible for the positive force-frequency relationships observed in most species. thus the force-frequency relationships were reevaluated in isolated atrial muscle of rat and mouse heart that show negative relationships, comparing them with ferret and guinea pig that show positive relationships. ryano ... | 1986 | 3789163 |
| hearing in the ferret (mustela putorius): thresholds for pure tone detection. | thresholds for pure tone detection were determined for two male ferrets (mustela putorius) using standard behavioral testing procedures. both animals had a broad range of hearing comparable to that seen in other carnivores. the lower limit of hearing at 60 db spl was estimated from the average audiogram to be 36 hz, and the upper limit of hearing was 44 khz. the lowest thresholds were found in the region of 8-12 khz with both animals exhibiting sharp tuning at best frequency. | 1986 | 3793642 |
| use of indirect and competitive elisas to compare isolates of equine influenza a virus. | antigenic differences within equine-1 and equine-2 isolates of influenza were studied by haemagglutination inhibition tests, indirect elisa and competition elisa, using the same antisera. better differentiation was obtained with the competition elisa than with the other two tests. all three methods produced similar relationships within the equine-1 isolates but differed in their ability to differentiate the equine-2 isolates where the competition elisa was superior and produced epidemiologically ... | 1986 | 3793836 |
| morphological features of spiking and nonspiking cells in the paratracheal ganglion of the ferret. | the present series of experiments was designed to study details of the morphology and connectivity of functionally identified cells located in the paratracheal ganglia of the ferret. the morphology of 11 spiking (ah cells) and seven nonspiking (type b cells) ganglion cells was examined. intra-axonally injected horseradish peroxidase (hrp) was used as the label. each spiking and nonspiking cell was identified by intracellular recording prior to the hrp injection. "whole mount preparations" were p ... | 1986 | 3794010 |
| metabolic consequences of increasing intracellular calcium and force production in perfused ferret hearts. | 31p nuclear magnetic resonance was used to measure the relative concentrations of phosphorus-containing metabolites in langendorff-perfused ferret hearts. intracellular concentrations of inorganic phosphate ([pi]i), phosphocreatine [( pcr]i), atp ([atp]i) and [h+] (phi) were determined. exposure of the heart to strophanthidin (10-40 microm) produced an increase in developed pressure over 5-10 min. in the presence of strophanthidin, [atp]i was unchanged, [pcr]i showed a small fall, [pi]i showed a ... | 1986 | 3795073 |
| proliferative colitis in a pet ferret. | a 4-month-old male ferret was examined because of mucus-laden diarrhea of several days' duration. the diarrhea became bloody and the ferret became progressively anorexic and lost weight. treatment with antibiotics did not result in amelioration of clinical signs. a biopsy specimen was obtained from the colon, which was thick and turgid. proliferative colitis associated with campylobacter sp infection was diagnosed histologically. because of the poor prognosis and potential zoonotic hazard associ ... | 1986 | 3804844 |
| measurement and control of intracellular magnesium ion concentration in guinea pig and ferret ventricular myocardium. | intracellular magnesium and sodium ionic concentrations have been measured in mammalian ventricular myocardium using ion-selective micro-electrodes. the values for [na+]i and [mg2+]i are 9.5 +/- 0.3 and 2.4 +/- 0.2 mm, respectively. increasing extracellular [mg] or decreasing extracellular [na] both caused a rise of [mg2+]i and a fall of [na+]i. superfusion with ouabain caused a small rise of [mg2+]i as well as a rise of [na+]i. reduction of extracellular [mg] or cell depolarisation had no effec ... | 1986 | 3807424 |
| differentiation in male ferrets of a sexually dimorphic nucleus of the preoptic/anterior hypothalamic area requires prenatal estrogen. | experiments were conducted to determine when during perinatal development testicular steroids act in ferrets to promote the organization of a bilateral nucleus in a medial position at the border of the preoptic area (poa) and anterior hypothalamus (ah), henceforth referred to as the male nucleus of the poa/ah (mn-poa/ah). the formation of the mn-poa/ah was promoted in female offspring by treating their mothers with testosterone over the last 11 days of the 42-day gestation period, whereas mn-poa ... | 1986 | 3808217 |
| host cell-mediated variation in h3n2 influenza viruses. | the influence of the host cell on the selection of antigenic variants of influenza a h3n2 viruses and the relevance of host cell selection to the induction of immunity by these viruses have been investigated. influenza viruses were isolated from human clinical samples during a single epidemic, were passaged in mammalian madin-darby canine kidney (mdck) cells or in embryonated hens eggs, and were tested for antigenic variability in the hemagglutinin (ha) molecule with a panel of monoclonal antibo ... | 1987 | 3811239 |
| mucus secretion by tracheas of ferret and dog. | mucus secretion, stimulated by nerve excitation or drugs, was measured from the ferret trachea in vitro by two methods: from the whole trachea, and compared with the volume of submucosal glands estimated from histological sections; and from mounted segments of trachea, by displacement of tantalum dust applied to the epithelium and compared with changes in tissue volume estimated by probing the epithelial surface between hillocks. maximal secretion rates (2-3 microliters x min-1 x cm-2) with trac ... | 1987 | 3817064 |
| production of passive immunity in neonatal ferrets following maternal vaccination with killed influenza a virus vaccines. | neonatal ferrets may be passively immunized following maternal vaccination with formalin-inactivated influenza a virus vaccine, but the level of protection from partial to complete depends upon the number of doses used to vaccinate the mother, the presence or absence of aluminum hydroxide adjuvant, whether or not the mothers were 'primed' by prior infection with a serologically heterologous type a virus, and the age of the neonate at challenge. neonates were completely protected up to 2 weeks of ... | 1987 | 3817868 |
| pathophysiology and pathogenesis of stunned myocardium. depressed ca2+ activation of contraction as a consequence of reperfusion-induced cellular calcium overload in ferret hearts. | contractile dysfunction in stunned myocardium could result from a decrease in the intracellular free [ca2+] transient during each beat, a decrease in maximal ca2+-activated force, or a shift in myofilament ca2+ sensitivity. we measured developed pressure (dp) at several [ca]0 (0.5-7.5 mm) in isovolumic langendorff-perfused ferret hearts at 37 degrees c after 15 min of global ischemia (stunned group, n = 13) or in a nonischemic control group (n = 6). at all [ca]0, dp was depressed in the stunned ... | 1987 | 3818956 |
| vagal afferent discharge from gastric mechanoreceptors during contraction and relaxation of the ferret corpus. | vagal afferent fibres with mechanoreceptive fields in the gastric corpus were studied electrophysiologically in the urethane-anaesthetized ferret in an attempt to assess how changes in muscle tension and length modulate receptor discharge. single afferent units were spontaneously active and increased their firing on distension of the corpus. during vagally evoked isovolumetric contractions and relaxations, the afferent discharge closely followed changes in intracorpus pressure. under near-isoton ... | 1987 | 3819312 |
| response of epithelial cells of the choroid plexus in the ferret model for reye's syndrome. | the structural integrity of epithelial cells of the lateral choroid plexus tissues from the ferret model for reye's syndrome was examined by transmission electron microscopy after the animals were inoculated intranasally with influenza b, were administered aspirin, and/or were fed an arginine deficient diet singly and in combination. no cellular alteration in the choroidal epithelium was caused by influenza b nor by aspirin, however, the synthetic diet produced random intercellular edema. the st ... | 1987 | 3821066 |
| does the substantia nigra have a cholinergic innervation? | we have studied the distribution of choline acetyltransferase-containing fibres in ferret substantia nigra using immunohistochemistry at the light microscopical level. positive staining for choline acetyltransferase was not observed in any nigral cell bodies, but was found in a network of fine-calibre, varicose axons, more densely distributed in the zona compacta than the zona reticulata. | 1987 | 3822242 |
| hepatic vascular neoplasms in a colony of ferrets. | 2013 | 3824828 | |
| an electron microscope study of vagus nerve composition in the ferret. | the total number of axons in the cervical and abdominal vagus nerves of the ferret was counted. the ratio of myelinated to non-myelinated, and afferent to efferent axons was determined. the fibre diameter spectrum of myelinated axons was measured. the total number of axons in the ferret cervical vagus is similar to other mammals (approximately 28,000); the majority of axons are afferent (approx. 24,000) and also the majority of axons are nonmyelinated (approx. 27,000). the dorsal abdominal trunk ... | 1986 | 3826653 |
| campylobacter jejuni infection in the ferret: an animal model of human campylobacteriosis. | campylobacter infection in weanling ferrets (mustela putorius furo) was studied as an animal model for enteric campylobacteriosis in persons. the screening of fecal cultures on selective campylobacter media showed that campylobacter jejuni/coli was not present in the normal enteric flora. intragastric feeding of a mixture of cat feed and 2.5 x 10(8) c jejuni isolated from ferrets with naturally occurring proliferative colitis was accomplished. all ferrets (n = 8) became infected on 3 days after ... | 1987 | 3826848 |
| canine distemper virus: in vivo virulence of in vitro-passaged persistent virus strains. | groups of ferrets were inoculated intraperitoneally with cell lysates or equivalent doses of whole cells from 9 different cell lines persistently infected with canine distemper virus. viral persistence in these cell lines was characterized by noncytolytic infection and restricted release of cell-free infectious virus. in vivo replication competency of the various viruses in ferrets ranged from nil to virulent and did not correlate with in vitro titers of inocula. ferret virulence (cell lysates o ... | 1987 | 3826861 |
| intestinal replication of influenza a viruses in two mammalian species. brief report. | the sites of replication of influenza a viruses in ferrets and pigs were studied. the majority of the swine, equine, and avian influenza a viruses tested were recovered from the intestinal tract of ferrets as well as from the respiratory tract; most of the human influenza viruses studied were recovered only from the respiratory tract. in contrast with ferrets, only hong kong/1/68 (h 3 n 2) influenza virus was recovered from the intestinal tract of pigs. despite the large biological variability f ... | 1987 | 3827601 |
| lymphangiography in ferrets infected with brugia malayi. | 1985 | 3835408 | |
| diagnostic exercise: lymphoproliferative disorder in a ferret. | 1985 | 3839547 | |
| age-related fiber order in the optic tract of the ferret. | in the ferret's optic tract, the position of retinofugal fibers has been related to their relative age by preferentially labeling the oldest fibers. it has been found that fiber order perpendicular to the pial surface represents the sequence of axon arrivals in the optic tract, the fibers furthest from the pia being the oldest. immature ferrets, less than 34 days post-conception (e34), were given intravitreal injections of lectin-bound horseradish peroxidase or of 3h-amino acids. after survival ... | 1985 | 3840527 |
| evidence of proceptive without receptive defeminization in male ferrets. | the latencies of groups of gonadectomized male and female ferrets to approach and interact with a sexually active stimulus male were measured after administration of estradiol benzoate (eb; 0, 5, 10, or 15 micrograms/kg) in adulthood. receptive responsiveness to stud males was also assessed in these same ferrets during additional tests. control female ferrets gonadectomized on postnatal day 35 displayed a dose-dependent reduction in approach latencies to the stud male which did not occur in cont ... | 1985 | 3843738 |
| demonstration of immunoglobulin in brains of ferrets inoculated with an sspe strain of measles virus: use of protein a conjugated to horseradish peroxidase. | measles virus-specific immunoglobulin g (igg) has been found in the brains of patients with subacute sclerosing panencephalitis (sspe), a slowly progressing central nervous system (cns) disease affecting children. igg/albumin ratios indicate that the antibodies are probably synthesized in the cns. in a ferret model system, protein a conjugated to horseradish peroxidase (prapx) was used to localize ig's in brains of animals inoculated with a cell associated strain of sspe. ig's were found in plas ... | 1985 | 3883686 |
| further studies of the reasons for the lack of alveolar infection during influenza in ferrets. | intratracheal inoculation of influenza virus in the ferret was followed by a more severe airway infection than that produced by nasal infection and was mainly bronchiolar rather than bronchial. also, virus isolation from the alveolar zone of the lung together with immunofluorescence and immunoperoxidase techniques showed that some virus reached the alveoli. nevertheless, there was no subsequent alveolitis suggesting the existence of a clearance phenomenon. alveolar macrophages were shown to have ... | 1985 | 3885997 |
| a rise in tonic luteinizing hormone secretion occurs during photoperiod-stimulated sexual maturation of the female ferret. | this study determined whether a rise in tonic secretion of lh occurred before long day-induced precocious puberty of the female ferret. twenty immature females were assigned to 1 of 2 photoperiods at 15 weeks of age. ten ferrets were placed in a long day, stimulatory photoperiod (16 h of light, 8 h of darkness) to induce sexual maturation, and 10 remained in the nonstimulatory photoperiod (8 h of light, 16 h of darkness) for the duration of the study. intensive blood sampling regimens (every 10 ... | 1985 | 3886370 |
| growth requirements of ferret tracheal epithelial cells in primary culture. | in mass cell culture conditions, protease dissociated ferret tracheal epithelial cells (fte) proliferated in growth factor-supplemented f12 medium to high cell densities (0.5 x 10(5) cells/cm2) with an average population doubling time of 24 hr. the growth factor constituents of the f12 medium included epidermal growth factor (25 ng/ml), insulin (1 microgram/ml), transferrin (10 micrograms/ml), hydrocortisone (18 ng/ml), hypothalamus extract (30-100 micrograms/ml), and conditioned medium from mou ... | 1985 | 3889927 |
| development of dirofilaria immitis third stage larvae (nematoda: filarioidea) in micropore chambers implanted into surrogate hosts. | groups of 100 third stage larvae of dirofilaria immitis recovered from aedes aegypti were loaded into 250 microliters capacity micropore chambers (0.3 micron pore size) and implanted into the peritoneal cavity of mice, jirds, cotton rats and ferrets. in all hosts 74-87% of larvae moulted by 74 hours, with less than 5% mortality. the fourth stage worms recovered at 74 hours were cultured in vitro in l-15 (leibovitz) medium plus 20% foetal bovine serum with a dog sarcoma feeder cell line. after 96 ... | 1985 | 3890119 |
| pharmacokinetics of ethanol in the ferret. | select doses of ethanol (25%, w/v) were administered to female ferrets (mustela putorius) by gastric intubation to determine dosage corresponding to peak blood alcohol levels (bal) greater than 100 mg/100 ml of blood (mg%) for an extended duration. low doses (6 ml/kg) resulted in peak bal of 202 mg% in 1.5 hr and 50 mg% after 12 hr. intermediate doses (8 ml/kg) resulted in peak bal of 253 mg% in 1.4 hr and 89 mg% after 12 hr. high doses (12 ml/kg) did not increase peak bal proportionately, resul ... | 1985 | 3890594 |
| responses of enzymatically isolated mammalian vascular smooth muscle cells to pharmacological and electrical stimuli. | a modified method for enzymatically isolating mammalian vascular smooth muscle cells has been developed and tested for ferret portal vein smooth muscle. this method produces a high proportion of fully relaxed cells and these cells appear to have normal pharmacological responsiveness. the ed50 values for both alpha stimulation and potassium depolarization are not significantly different in the isolated cells from those obtained from intact strips of ferret portal vein, suggesting that the enzymat ... | 1985 | 3892474 |
| use of ferrets in studies of the visual system. | the ferret (mustela putorius furo) is proving to be an excellent experimental animal for many anatomical and physiological studies of the adult and developing visual system. as a result, the amount of data available on the ferret's visual system is increasing at a rapid rate. the purposes of this paper are to briefly review some of those data and to present some of the reasons why the ferret is an appropriate choice as an experimental animal for visual system studies. | 1985 | 3894786 |
| the forebrain of the ferret. | the basic neuroanatomy of the forebrain, mainly of the telencephalon, of the adult ferret (mustela furo), is reviewed and illustrated with special references to the features that distinguish this animal from other carnivores. references to the pertinent literature describing similar regions of other carnivores are cited. | 1985 | 3894787 |
| localization of measles virus antigens in subacute sclerosing panencephalitis in ferrets. | young adult male ferrets were inoculated intracerebrally (i.c.) with a cell-associated encephalitogenic subacute sclerosing panencephalitis (sspe) virus strain to study the pathogenesis of the disease at the ultrastructural level. most became acutely ill in 8-13 days. areas of the brain were examined with indirect immunoperoxidase labeling techniques to detect measles antigen. none of these animals showed the characteristic viral nucleocapsids or marked inflammatory response associated with sspe ... | 1985 | 3894788 |
| behavior and neurobehavioral teratology using the ferret. | a behavioral profile of the ferret is presented for those who would like to use this animal in behavioral teratology and toxicology, or other disciplines involving behavior. we have reviewed neurobehavioral teratology of lisencephalic ferrets and neuropsychology of ferrets sustaining frontal lesions, as well as most of the studies of "normal" ferret behavior that have appeared in the research literature. emphasis is placed on discussion of the tests used and how ferrets behaved on them. the beha ... | 1985 | 3894789 |
| laboratory management of the ferret for biomedical research. | ferrets have become an increasingly important animal in biological research. this paper discusses unique aspects of the ferret's anatomy, reproductive behavior, husbandry, and diseases as they relate to the research use of this animal. | 1985 | 3894790 |
| compendium of recent literature on the ferret. | a survey of research publications since 1977 indicated that the ferret is a rather popular research animal. using the biosis and medline data bases, 569 citations of research involving the ferret were identified. over 27% of these citations involved the use of ferrets in the field of physiology, and an additional 24% of the citations were in virology and immunology. the areas of pharmacology, toxicology and teratology accounted for 10.4, 8.4 and 4.0% of the citations, respectively. | 1985 | 3894791 |
| endocrine factors in haematological changes seen in dogs and ferrets given oestrogens. | high doses of oestrogens in the dog and ferret cause myeloid hyperplasia in the bone marrow superseded by hypoplasia affecting all cell lines. in the peripheral blood after an initial leucocytosis, there is thrombocytopenia, anaemia and leucopenia. these effects, which are ultimately lethal, do not occur in cats, rats and monkeys, and their cause is unknown. it is speculated that they may be due to endocrine derangements possibly affecting the pituitary-adrenal axis and that species differences ... | 1985 | 3921810 |
| [testicular activity of the ferret kept for over 4 years under permanent light and constant temperature]. | five male ferrets, aged 2 months, were kept in constant light (4-5 lx) and temperature (15 +/- 1 degree c) from july 1979 to september 1983. under these experimental conditions, the testicular size displayed spontaneous variations. four cycles, characterized by a marked testicular enlargement followed by an equivalent decrease, were observed in three ferrets. the two others exhibited only three spontaneous cycles. the mean interval between two successive maximums equalled 340 +/- 28 days. | 1985 | 3928102 |
| antitumor activity and toxicity in animals of bmy-25282, a new mitomycin derivative. | bmy-25282, 7-n-(dimethylamino methylene)mitomycin c, is one of a novel series of amidino mitomycin derivatives. some of these were discovered as intermediates in a synthetic program being conducted to find improved procedures for modifying the structure of mitomycin c (mmc). markedly superior in vivo antitumor effects have been observed with bmy-25282 compared to mmc in initial tests against i.p.-implanted p388 leukemia and b16 melanoma. when administered i.v. to mice bearing s.c. b16 melanoma, ... | 1985 | 3933826 |
| the effects of amrinone and related drugs on intracellular calcium in isolated mammalian cardiac and vascular smooth muscle. | the effects of amrinone and related agents were studied in mammalian cardiac and vascular smooth muscle preparations loaded intracellularly with aequorin, a bioluminescent calcium indicator that emits light when it combines with ca++. in cat papillary muscles, the effects of amrinone on the amplitude and time course of the aequorin light signal, as they relate to changes in uptake and release of calcium from the sarcoplasmic reticulum and to changes in the sensitivity of the myofilaments to ca++ ... | 1986 | 3943182 |
| heterologous anti-progesterone monoclonal antibody arrests early embryonic development and implantation in the ferret (mustela putorius). | early embryo development and implantation were arrested in ferrets passively immunized with a mouse monoclonal anti-progesterone antibody injected intraperitoneally at 72 and 96 h post coitum (p.c.) or at 72 h p.c. only. in control ferrets injected with mouse serum or 0.9% nacl, implantation sites were found in all mated females; autopsies were carried out at day 14 p.c. a total of 34 unimplanted embryos were recovered from the reproductive tract of antibody-treated ferrets and none of these had ... | 1986 | 3944809 |
| is there a critical weight for oestrus in the ferret? | information concerning the weight at the onset of a period of oestrus, the timing of oestrus, the age at first oestrus and the lighting conditions was collected from the records of 1364 ferrets and reviewed for evidence indicating that the animals became sexually mature around a particular, critical, weight. none was found, but the results suggest that there is a minimum weight, around 420 g, below which oestrus does not occur. | 1986 | 3944810 |
| comparative studies of h3n2 influenza virus strains isolated in may-june, 1982, and in the subsequent epidemic in february, 1983: antigenic and genome analysis. | comparative studies have been undertaken on the h3n2 influenza virus strains isolated in leningrad in may-june, 1982 and those isolated in the subsequent winter epidemic in february, 1983. analysis of the isolates with ferret antisera against standard influenza viruses of the h3n2 subtype and with monoclonal antibodies against a/bangkok/1/79 virus revealed a considerable but similar degree of heterogeneity in the ha antigenic specificity of the strains isolated in the spring-summer, 1982, as in ... | 1986 | 3947238 |
| sexual dimorphism in the preoptic/anterior hypothalamic area of ferrets: effects of adult exposure to sex steroids. | the organization of neuronal cell bodies in the caudal preoptic area (poa) and rostral anterior hypothalamic area (ah) was studied in nissl-stained brain sections from adult male and female ferrets. computer-assisted image-analysis procedures were developed to help estimate the areas of cellular density and the sizes of individual perikarya. at the junction of the poa and ah, a bilateral dorsal-medial group of neurons was apparent only in male ferrets (dorsal nucleus). at the same coronal level, ... | 1986 | 3947970 |
| phase i study of ethylenediamine platinum(ii) malonate (nsc 146 068), a second generation platinum analogue. | ethylenediamine platinum(ii) malonate [jm-40 (nsc 146 068)] has been selected for clinical studies because of its favorable preclinical toxicity profile as a "second generation" platinum analogue. when compared to cisplatin, jm-40 was less emetic in the ferret and less nephrotoxic in the dog, while its antitumor activity approached that of cisplatin. twenty-nine patients received 86 courses of jm-40 as a single dose every 3-4 wk. after 13 dose escalation steps the maximum tolerable dose was reac ... | 1986 | 3948186 |
| severity of fever in influenza: differential pyrogenicity in ferrets exhibited by h1n1 and h3n2 strains of differing virulence. | intracardial inoculation of large quantities (200 micrograms viral protein/kg body weight) of infectious or u.v.-inactivated purified influenza viruses into ferrets resulted in a rapid febrile response which was significantly lower for two recently isolated h1n1 viruses, a/ussr/90/77 and a/fiji/15899/83, than for two virulent clones, 7a and 64c, of the a/puerto rico/8/34-a/england/939/69 (h3n2) reassortant virus system. these results, which are in accord with the severity of fever produced by th ... | 1986 | 3950579 |
| characterization of the mechanical behavior of isolated papillary muscle preparations of the ferret. | the characteristics of isometric and isotonic contraction were studied in isolated papillary muscle preparations from the right ventricle of the ferret and compared with those previously reported for comparable preparations from cat and rat. the effects of stimulation rate, temperature, extracellular calcium concentration, caffeine, verapamil, and ouabain were measured. afterloaded contractions and load clamps were used to study the mechanics of relaxation. the contractile characteristics of fer ... | 1986 | 3951236 |
| [heat perils in ferrets]. | 1986 | 3952723 | |
| campylobacter-like organisms isolated from gastric mucosa of ferrets. | campylobacter-like organisms (clo) were isolated from gastric lesions in 1 ferret and gastric mucosa of 2 healthy ferrets. the organism was not isolated from biopsies of gastric mucosa of 14 other healthy ferrets, 1 of which had small gastric lesions located at the pylorus. lesions from which clo were isolated were located in the antrum of 1 ferret and were classified as inflammation with repair. affected gastric tissue was highly vascularized with fibrous connective tissue surrounding irregular ... | 1986 | 3954197 |
| plasma and pineal melatonin levels in female ferrets housed under long or short photoperiods. | ovohysterectomized female ferrets were housed in controlled environment rooms in which the daily lighting schedule was either 15l:9d (long days) or 9l:15d (short days). after 2 weeks some ferrets in each group were given an intrajugular catheter: beginning 1 week later, a blood sample was taken daily at one of eight different clock times over an 8 to 10 day period. one additional blood sample plus the pineal gland were collected from these animals and from uncathetarized animals in each group af ... | 1986 | 3955143 |
| effect of arginine-free diet on ammonia metabolism in young and adult ferrets. | two-month-old, male ferrets were fasted for 16 h and fed a synthetic, arginine-free diet. within 2-3 h after ingesting the diet, they developed hyperammonemia and encephalopathy. ammonia levels in the serum, brain and cerebrospinal fluid were greatly elevated compared to those of ferrets fed the synthetic diet supplemented with arginine. orotic acid and glucose levels in serum were also significantly elevated. urinary orotic acid was significantly increased but citrate and creatinine level were ... | 1986 | 3958802 |
| focal hepatic necrosis in young ferrets infected with aeromonas species. | 1986 | 3959372 | |
| blastomycosis in a ferret. | an 18-month-old female ferret with an ulcerated metacarpal pad and signs of respiratory illness was diagnosed as having blastomycosis by visualization of organisms on a tissue imprint, an agarose gel immunodiffusion test, and thoracic radiography. the ferret was treated intravenously with amphotercin b at 0.4 to 0.8 mg/kg and orally with ketoconazole at 8 mg/kg for approximately 1 month, during which time clinical and radiographic improvement was noted. a change to sc amphoterocin b therapy resu ... | 1985 | 3965428 |
| polycystic kidneys in a ferret. | polycystic kidneys were found at necropsy in an adult ferret with a history of seizures and a palpable abdominal mass. both kidneys contained numerous fluid-filled cysts of various sizes. the ferret may provide an animal model for the study of polycystic disease in man. | 1985 | 3965430 |
| amrinone effects on electromechanical coupling and depolarization-induced automaticity in ventricular muscle of guinea pigs and ferrets. | the effects of the cardiotonic agent, amrinone (0.05-4 mm), on electrical and mechanical activities of ferret and guinea-pig papillary muscles were studied using current and voltage clamp (single sucrose gap) techniques. in current clamp studies, amrinone increased, in a dose-dependent manner, contractile force elicited by action potential in both species. depolarization-induced automaticity was facilitated in ferret muscles at all maximum diastolic potentials between -70 and -15 mv. facilitatio ... | 1985 | 3965687 |
| retinotopic order appears before ocular separation in developing visual pathways. | in mammals, the major subcortical visual structures receive projections from both eyes, with the uncrossed projection being smaller than the crossed. each projection is arranged as a separate orderly map of one hemiretina. although these hemiretinal maps are separate in the nuclei, they are aligned so that the representations of points in the visual field are in register, thus there is a continuity of visual field representation between them. during the early development of the binocular pathway ... | 2007 | 3969159 |
| high-time-resolution 31p nmr studies of the perfused ferret heart. | a cell is described that has enabled isolated langendorff-perfused ferret hearts to be studied in a bruker wm200 widebore superconducting nuclear magnetic resonance (nmr) spectrometer. left ventricular pressure was monitored with a latex balloon catheter, and the hearts were paced with a stimulator triggered from the spectrometer's central computer, enabling gated studies to be performed. suitable radiofrequency filtering for the pacing leads is described. phosphorus (31p) nmr was used to determ ... | 1985 | 3969517 |
| cellular ca2+ monitored by aequorin in adenosine-mediated smooth muscle relaxation. | we studied the effect of adenosine on cytoplasmic ionized calcium-force relationships in vascular smooth muscle (vsm) and determined the dose dependence of the observed effects. the bioluminescent protein aequorin was used as an index of cytoplasmic ionized calcium and was chemically loaded into ferret portal vein strips. the vsm strips were contracted with 33 mm potassium (k+), 5 x 10(-6) m phenylephrine (pe), or electrical stimulation. force and aequorin light, i.e., cytoplasmic ionized calciu ... | 1985 | 3970168 |
| antigenic heterogeneity among influenza a(h3n2) field isolates during an outbreak in 1982/83, estimated by methods of numerical taxonomy. | fourteen influenza a(h3n2) field isolates, mainly obtained during the first weeks of the 1982/83 influenza epidemic in the netherlands, and nine influenza a(h3n2) reference strains were examined by means of haemagglutination inhibition (hi) tests with 23 polyclonal ferret sera. the resulting hi patterns were subjected to various methods of numerical taxonomy using, among others, taxonomic distance and correlation between strains for resemblance coefficients. marked differences between distance a ... | 1985 | 3973384 |
| androgen and estrogen receptors in perinatal ferret brain. | using dna-cellulose affinity chromatography and either 3h-labeled dihydrotestosterone, testosterone, or estradiol, we qualitatively and quantitatively analyzed the androgen- and estrogen-binding activities present in four regions of male and female ferret brain at prenatal, early and late neonatal, and adult ages. the cytosolic androgen- and estrogen-binding activities in ferret brain at all ages studied were qualitatively similar in both sexes and in all brain regions and exhibited characterist ... | 1985 | 3973666 |
| postpneumonectomy airway growth in the ferret. | to investigate the participation of the conducting airways in compensatory growth following partial lung resection, bronchial casts of six ferrets having undergone right-sided pneumonectomy at 8 wk of age were compared with those of five sham-operated control animals. at maturity, the left lungs of the postpneumonectomy animals were 65% larger than those of the controls. central airway cross-sectional areas at 10 specific locations in each cast were 12% larger in the postpneumonectomy animals co ... | 1985 | 3980371 |
| a technique for quantitating airway size from bronchial casts. | to develop a technique for quantitating the size of airways at various positions in the bronchial tree, we analyzed casts of formalin-fixed excised lungs of five mature male ferrets. the left lower lobe of each cast was dissected, the diameter and position of each terminal bronchiole were entered into a computer programmed to reconstruct the airway system, and the cross-sectional areas of 120 conducting airways were measured. the fraction of the lobe served by each measured airway was estimated ... | 1985 | 3980372 |
| infectivity of canadian isolates of trichinella spiralis nativa for swine, rats and carnivores. | the infectivity of trichinella spiralis nativa isolates from widely separated geographic areas of canada was determined by feeding infected musculature to swine, laboratory rats and carnivores (cats, foxes, ferrets). low infectivity for swine and rats and high infectivity for carnivores were observed. light infections were established in four of 16 swine examined between 25 and 53 days postinfection. feeding of infected porcine musculature to ferrets demonstrated that trichinella spiralis nativa ... | 1985 | 3986683 |
| androgen aromatization and 5 alpha-reduction in ferret brain during perinatal development: effects of sex and testosterone manipulation. | ferrets of both sexes were killed 8 or 5 days before expected parturition as well as 7, 15, 30, or 51 days after birth, and the activities of aromatase (using 19-[3h]hydroxyandrostenedione as substrate) and of 5 alpha-reductase (using [3h] testosterone as substrate) were assayed in whole homogenates of preoptic area plus anterior hypothalamus (poa), mediobasal hypothalamus (mbh), temporal lobe (tl), and cerebral cortex. aromatase and testosterone 5 alpha-reductase activities were also measured i ... | 1985 | 3987621 |