Publications

rhesus monkey (macaca mulatta) allotypes. identification of three low density lipoprotein allotypes controlled by independent genes.	three rhesus monkey allotypes are described, which are located on distinct low density lipoprotein molecules. these three markers have been detected using double immunodiffusion in agar. they are inherited in a simple mendelian manner and controlled by three independent genes.	1979	221424
lymphocyte activation by the tumor-promoting agent 12-o-tetradecanoylphorbol-13-acetate (tpa).	tpa, a highly active tumor-promoting agent, is an effective mitogen for primate peripheral blood lymphocytes. optimal stimulation of human lymphocytes was obtained 4 days after the addition of tpa at a concentration of 7.5 ng/ml. lymphocyte fractionation experiments demonstrated that both t and b cells incorporated 3h-thymidine significantly in response to tpa. lymphocyte blastogenesis was not due to the reactivation of latent herpesviruses by the tumor promoter, since similar responses to tpa w ...	1979	221578
accumulation and loss of cholesterol esters in monkey arterial smooth muscle cells exposed to normal and hyperlipemic serum lipoproteins.	the effects of high low and very low density lipoprotein fractions from normal or hyperlipemic rhesus monkey serum on the accumulation or removal of cholesterol esters from rhesus monkey smooth muscle cells in tissue culture were determined. serum or serum lipoproteins were labeled with [14c] free cholesterol and adjusted to the same free cholesterol level in the incubation medium. of the two normal lipoproteins examined, the ldl fraction caused more esterification than the hdl. cells incubated ...	1979	222304
disparate effects of prostaglandins on basal and gonadotropin-stimulated progesterone production by luteal cells isolated from rhesus monkeys during the menstrual cycle and pregnancy.		1979	222373
comparison of cynomolgus and rhesus monkey kidney cells for recovery of viruses from clinical specimens.	in a study of virus recovery from clinical specimens, cynomolgus monkey kidney cells demonstrated sensitivity equivalent or slightly superior to rhesus kidney cells for siolation of myxo- and paramyxoviruses, adenoviruses, and enteroviruses.	1979	222808
the emergence of simian virus 40 variants in a persistent infection of rhesus monkey kidney cells and their interaction with standard simian virus 40.		1979	223294
responses of immune and nonimmune adult rhesus macaques (macaca mulatta) to adenovirus sv-20.	adenovirus sv-20 (asv-20) was inoculated subcutaneously into adult rhesus macaques (macaca mulatta), and various immunologic parameters were studied. similar changes were observed in macaques that had anti-asv-20 serum-neutralizing antibodies prior to inoculation and in those lacking detectable antibodies. there were absolute decreases in numbers of peripheral blood lymphocytes (pbl), erythrocyte-rosetting lymphocytes, complement-receptor lymphocytes, and fc-receptor lymphocytes. these changes w ...	1979	223477
atherogenic diets and neutral-lipid organization in plasma low density lipoproteins.	the plasma low density lipoproteins (ldl) of rhesus monkeys fed 3 atherogenic diets exhibited thermal transitions at temperatures much higher (37--43 degrees c) than those observed in control animals or in normal humans (20--33 degrees c). the same differences were noted in the neutral lipids (cholesteryl esters and triglycerides) which were isolated from the respective lipoproteins. in particular, the difference in thermal properties between the normal and abnormal ldls was attributable to subt ...	1979	223602
isolation and characterization of the three major low density lipoproteins from normolipidemic rhesus monkeys (macaca mulatta).		1979	224061
experimental interfascicular nerve grafting.	twenty-nine adult rhesus monkeys underwent complete laceration of both tibial nerves at mid-thigh level and repair by different methods to study the relative efficacy of autogenous interfascicular nerve grafts. sixteen animals in group i had an interfascicular graft repair using short sural nerve autografts on one limb and fascicular repair without grafts on the other limb. thirteen animals in group ii, after having a 1-cm segment of tibial nerve resected, had an interfascicular graft repair wit ...	1979	224152
experimental adenovirus sv-20 pneumonia in fetal rhesus monkeys. pathologic and virologic studies.		1979	224262
small plaque variants of simian virus 40 from a persistent infection of rhesus monkey kidney cells.		1979	224576
regulation of primate testicular luteinizing hormone receptors and steroidogenesis.	the testicular luteinizing hormone (lh) receptors of the rhesus monkey and human have many features in common, including high equilibrium association constant, marked species specificity, and relatively low binding capacity. we have, therefore, used rhesus monkeys as models for human lh-receptor regulation in vivo during gonadotropin treatment. in four adult male monkeys, treated with 10,000 iu human chorionic gonadotropin (hcg), serum and testicular steroidogenic responses were monitored at 24- ...	1979	225351
immune response of monkeys (macaca mulatta) to amebic antigens.		1979	225462
physostigmine and recent memory: effects in young and aged nonhuman primates.	the effect of physostigmine on recent memory was evaluated in young and aged rhesus monkeys. all aged monkeys had previously shown impaired memory. the performance of the young monkeys treated with physostigmine was similar to that recently reported for young humans--no effects at low doses, some improvement at a restricted range of doses, and deficits at the highest dose. although the aged subjects also improved at the same general doses, their overall response as a group was much more variable ...	1979	227061
effect of chronic cocaine on behavior and cyclic amp in cerebrospinal fluid of rhesus monkeys.		1979	227642
comparison of different tissue cultures for isolation and quantitation of influenza and parainfluenza viruses.	rhesus and cynomolgus monkey kidney tissue cultures and two continuous lines, madin-darby canine kidney (mdck) and llc-mk2, were compared in titrations and isolations of influenza and parainfluenza viruses. tube cultures were inoculated with laboratory virus strains or stored patient specimens and observed for hemadsorption. trypsin was added to the medium of the continuous lines to increase sensitivity. all four tissue cultures gave similar titers of influenza a/ussr (h1n1), a/texas (h3n2), and ...	1979	227920
estimation of gestational and skeletal age in macaca mulatta.	results of qualitative and quantitative studies of prenatal skeletal development in macaca mulatta are presented. longitudinal radiographic observations were carried out on 20 monkeys of known gestational age, beginning on 120 days of gestation until the neonatal stage of skeletal development. these studies were based on multiple uterotomies on each pregnant female. the technique described provides accurate data on prenatal bone ossification, and permits an accurate estimation of fetal age in pr ...	1979	228041
chronic hyperinsulinemia in the fetal rhesus monkey: effects on hepatic enzymes active in lipogenesis and carbohydrate metabolism.	hyperinsulinemia was produced in fetal rhesus monkeys for 21 days in the last third of gestation by subcutaneous pork insulin injected at 19 u a day. plasma insulin concentrations in treated fetuses (n = 4) were 3525 microu/ml. there was no difference in paired pre- and post-treatment fetal plasma glucose concentration. activity of the hepatic enzymes that promote glucose utilization (glucokinase and hexokinase) and glycolysis (phosphofructokinase, pyruvate kinase, and pyruvate dehydrogenase) wa ...	1979	229050
virus detection in monkeys with diarrhea: the association of adenoviruses with diarrhea and the possible role of rotaviruses.	to explore the role of viruses in the etiology of diarrhea in colony-reared monkeys, direct electron microscopy, the fluorescent virus precipitin test and cell culture inoculation were used to examine the stools of monkeys with and without diarrhea. the animals were predominantly rhesus with a few macaques of other species, and included infants, juveniles and adults. adenoviruses were isolated from a higher proportion of specimens from rhesus monkeys with diarrhea (73% of specimens from infants ...	1979	229340
[zinc activated tartrate resistent phosphatases in the brains of different animal species and their characterization].	a zinc activated tartrate resistent phosphatase (zntp) of the brain of different animal species was separated by electrofocusing in polyacrylamide gels. it is demonstrable selectively in the presence of 20 mm zinc acetate and 10 mm d,l-sodium tartrate or of 100 mm zinc acetate only. the zntp hydrolyzes 1-naphthyl phosphate and 4-nitrophenyl phosphate, respectively. high activity of zntp is evident in the brains of rats and rabbits. the activity is moderate or absent in the brains of mice, syrian ...	1979	230670
rotavirus antibody assays on monkey sera: a comparison of enzyme immunoassay with neutralization and complement-fixation tests.	an enzyme immunoassay (eia) for the detection of rotaviral antibodies was developed, using a purified, cell culture-grown sa 11 viral antigen and alkaline phosphatase as an enzyme label. this technique was evaluated by comparative testing with tube neutralization and complement-fixation assays on a collection of simian sera. there was close correlation between positive and negative results obtained by eia and by neutralization. the eia was as easy to perform as complement fixation testing, but s ...	1979	230760
isolation and characterization of a new simian foamy virus serotype from lymphocytes of a papio cynocephalus baboon.	a new type of syncytium-forming (foamy) virus was isolated from peripheral lymphocytes of a papio cynocephalus baboon after cocultivation with a rhesus monkey cell line. the isolate was characterized by cytopathogenic effect, host range, electron microscopy, reverse transcriptase activity and physical and chemical properties. seroneutralization tests indicate that the new isolate is antigenically distinct from the other nine known simian foamy virus serotypes.	1979	231658
nor-mdp, saponin, corynebacteria, and pertussis organisms as immunological adjuvants in experimental malaria vaccination of macaques.	vaccination of primates against malaria using antigen derived from erythrocytic parasite stages has been most successful where freund's complete adjuvant has been employed. since this adjuvant is clinically unacceptable its replacement is a matter of urgency.in the present work a muramyldipeptide derivative (nor-mdp) given in mineral oil has proved to be partially effective as an adjuvant for merozoite vaccination of macaca mulatta against plasmodium knowlesi, and saponin has proved to be effect ...	1979	232428
classically conditioned heart rate responses in macaca mulatta after beta-adrenergic, vagal and ganglionic blockade.	heart rates of 5 rhesus monkeys (macaca mulatta) were monitored during classical conditioning trials consisting of a visual conditioned stimulus followed after 10 sec by an electric shock to the tail. heart rates typically increased at the onset of the visual stimulus, and returned to baseline before shock delivery. autonomic blocking agents were subsequently administered; their effects on resting heart rates, and on acceleratory and deceleratory phases of the biphasic conditioned heart rate res ...	1979	233311
pathology of modified graft-versus-host disease in bone marrow allografted monkeys treated with antilymphocyte serum.	lethally irradiated rhesus monkeys were used for bone marrow allografting and autografting. monkeys receiving allogeneic bone marrow developed acute graft-versus-host reaction (gvhr) and had a mean survival time of 9.1 days as compared to autografted monkeys which survived above 500 days. treatment with antilymphocyte sera (als) before allografting modified the gvhr and extended the survival time to an average of 43 days. histologically, such animals showed evidence of "chronic" gvhr and septice ...	1975	234261
studies on thermogenesis in brown adipose tissue in temperature-acclimated macaca mulatta.		1975	234336
hyperreactive arterial endothelial cells in atherogenesis and cyclic amp phosphodiesterase inhibitor in prevention and treatment of atherosclerotic disorders.	the hyperreactive arterial endothelial cells have been introduced in this paper. they are characterized by their ability to transport particles too large for the small holes of the internal elastic lamina locating underneath the endothelial cells, such as carbon particles with the similar size of ldl, floating beta-lipoprotein, lp(a) and especially of vldl, into the subendothelial space from the blood stream by their abnormally strong contracting and phagocytosis-like activity. large particles s ...	1975	234547
oxisuran metabolism in the monkey.	oxisuran metabolism was studied in the rhesus monkey in order to assess the suitability of this species as an immunological model for man. the biotransformation pathways observed in the monkey are the same as those seen in rats and dogs. these pathways include the oxidation of oxisuran to a sulfone not found in human plasma or urine. nevertheless, the monkey may merit immunological evaluation because the half-lives of biotransformation and elimination, although shorter than those exhibited by ma ...	1975	234829
phagocytosis of francisella tularensis by rhesus monkey peripheral leukocytes.	phagocytosis of francisella tularensis by rhesus monkey peripheral neutrophils (pmn, was assessed by autoradiography, electron microscopy, and biochemical techniques. pmn, in contrast to mononuclear phagocytes, were unable to phagocytize f. tularensis in vitro in the absence of immune serum. it is postulated that in the nonimmune host the innate inability of pmn to phagocytize f. tularensis deletes one of the possible mechanisms of host defense to bacterial infection and thus permits the early d ...	1975	234911
central nervous system findings in the newborn monkey following severe in utero partial asphyxia.	seizures, brain swelling, and cortical necrosis have been observed in the newborn rhesus monkey following a 2 to 4-hour period of intrauterine partial asphyxia produced by halothane-induced maternal hypotension. these clinical and neuropathologic findings are similar to those seen in human newborn infants who have experienced an episode of intrauterine asphyxia from such a cause as premature placental separation. the present study strongly indicates that fetal partial asphyxia, from any cause, i ...	1975	235749
effect of water and mouthwashes on ph of oral monkey mucosa.	among the many factors involved in homeostasis, maintenance of hydrogen-ion concentration is one of the most important functions of the body. surface ph measurements of oral tissues after rinsing with water or mouthwashes are meager. this report presents results of the effect of tap water and 9 commercial mouthwashes on intraoral ph under controlled conditions. nine rhesus monkeys, 5 females and 4 males between 3 and 8 years of age, were used in this study. during measurements they were sedated ...	1975	235766
accelerated host metabolism of l-thyroxine during acute infection: role of the leukocyte and peripheral leukocytosis.	metabolism of thyroid hormones is accelerated during acute infection in man and in experimental animals. the pathogenetic mechanisms mediating this phenomenon are uncertain, but activated leukocytes of the infected host have been implicated as potentially important sites of hormone degradation. the present studies were conducted in an attempt to assess the in vivo contribution of leukocytes and peripheral leukocytosis to the enhancement of l-thyroxine (t4) clearance seen during infection, and to ...	1975	236322
immunogenicity of formaldehyde-inactivated enterotoxins a and c1 of staphylococcus aureus.	quantitative precipitation of antisera specific for native enterotoxin revealed that 70% and 60%, respectively, of the antigenic determinants of enterotoxins a and c1 of staphylococcus aureus were inactivated by formaldehyde at ph 5.0 or 7.5 contained large polymers (excluded by sepharose 2b) and induced strong humoral immune responses in rhesus monkeys. enterotoxin a inactivated at ph 5.0 or 7.5 was composed mostly of small polymers (excluded by sephadex g-100 but included by sepharose 2b); it ...	1975	236345
aflaxation b1 hydroxylation by hepatic microsomal preparations from the rhesus monkey.		1975	236980
the effects of premedication drugs on the lower oesophageal high pressure zone and reflux status of rhesus monkeys and man.	thirty-five human volunteers and eight rhesus monkeys were studied with standard gastrooesophageal manometric techniqes and their reflux status was evaluated witha ph probe placed in the lower oesophagus. morphine sulphate, pethidine hydrochloride, or idazepam was given intravenously until drowsiness was induced. the manometric and ph studies were repeated. all three drugs decreased the lower oesophageal high pressure zone and increased the probability of relux in both monkeys and man. thes fi ...	1975	237803
proceedings: successful treatment of delayed arterial spasm in the rhesus monkey after subarachnoid haemorrhage.		1975	237988
experimental models of oculomotor dysfunction in the rhesus monkey.		1975	238373
response of the primate fetus to intra-amniotic saline injection.	the amniotic fluid was replaced with 20 per cent sodium chloride solution during the second half of gestation in 12 pregnant rhesus monkeys. this produced a congealing of the fetal blood in the small umbilical vessels which overlie in the placental chorionic plate. death of severe asphyxia followed within 20 to 50 minutes in the younger fetuses due to a prompt cessation of umbilical blood flow. during this time, the rise in serum sodium of the fetus was moderate and could not be implicated as th ...	1975	238395
systemic and regional blood-flow changes during spinal anesthesia in the rhesus monkey.	the radioactive microsphere technique was used to determine the distribution of cardiac output and regional blood flow in rhesus monkeys before and 10,20,40, and 80 minutes after induction of spinal anesthesia. five monkeys were studied during low spinal anesthesia (sensory level t10) and five other monkeys were studied during high spinal anesthesia (sensory level t1). each monkey served as its own control. there was no significant change in regional blood flow during t10 spinal anesthesia. duri ...	1975	238435
selective autonomic blockade of conditioned and unconditioned cardiovascular changes in rhesus monkeys (macaca mulatta).	changes in heart rate and in systolic and diastolic blood pressures were examined in eight rhesus monkeys during six sessions of differential classical conditioning. the conditioned stimuli consisted of tones differing in frequency and the unconditioned stimuli consisted of tail shock. both the conditioned responses (crs) and unconditioned responses (ucrs) consisted of increases in heart rate and in systolic and diastolic pressures, but blood pressure crs sometimes occurred in the absence of hea ...	1975	240876
morphological differences in the central nervous system and organs of monkeys inoculated intracerebrally with virulent and attenuated strains of mumps virus.	the degree of attenuation of mumps virus was studied in intracerebrally inoculated macaca mulatta monkeys. the virulent leningrad-3 strain and its attenuated variant as well as the attenuated sophia-6 strain were used. the nature of pathological alterations in the neurons pointed to neurotropism of only the virulent strain. morphological changes caused by attenuated and virulent strains in the brain structures, in the epithelium and glandular structures of the salivary glands differed considerab ...	1975	241228
pharmacologic control of uterine contractility. in vitro human and in vivo monkey studies.	the exact cause and mechanism of the onset of labor are unknown but the theories are many. there is considerable evidence that prostaglandins are potent stimulants of uterine activity and may play a role in the onset of labor. prostaglandin release may be the natural mediator of uterine contractions during labor. a group of anti-inflammatory compounds (aspirin-like compounds) that inhibit prostaglandin synthesis include indomethacin and fenoprofen. inhibition of prostaglandin production is a rea ...	1975	241259
sequential immunologic stimuli to the respiratory tract: a paradox in the degree of potentiation of airway responses depending on the sequence of reverse passive and active immunologic stimulation.	immunologic stimuli to the airway of rhesus monkeys were given by aerosol challenge with ascaris antigen or anti-ige. both of these stimuli produce immediate-type airway responses. when 2 sequential aerosol challenges were given during the same experiment, the response following the second stimulus was always less than or equal to the first response following any combination of stimuli except the anti-ige-ascaris sequence. the second response following the latter challenge was always greater tha ...	1977	262105
time-action and behavioral effects of amphetamine, ethanol, and acetylmethadol.	as time increased between drug administration and the start of experimental sessions, effects of drugs on food-maintained responding in rhesus monkeys increased to a maximum and then decreased. d-amphetamine, ethanol, and alpha-l-acetylmethadol (laam) generally decreased high response rates in one component of a chain schedule, while very low response rates in another component were increased reliably only by ethanol. the time of peak laam and ethanol concentrations in blood or plasma correspond ...	1977	263550
clinical aspects of the visually evoked potential.	the visually evoked potential (vep) was studied in normal and abnormal human subjects, and in rhesus monkeys. a relatively simple protocol for clinical vep testing is described. the monkeys showed similar but smaller vep responses compared to those obtained from human subjects. central, but not paracentral or peripheral photocoagulation retinal lesions were associated with vep abnormalities. the second, smaller wave of the response complex to 10 hz flash stimuli corresponds to the primary evoked ...	1978	263987
iron metabolism and placental transfer of iron in the term rhesus monkey (macaca mulatta): a compartmental analysis.	the kinetics of iron and the transplacental iron transport in the near-term rhesus monkey were investigated by means of injection of 59fe(iii) bound to rhesus monkey transferrin into the maternal or into the fetal circulation. the experimentally obtained 59fe(iii) bound to rhesus monkey transferrin into the maternal or into the fetal circulation. the experimentally obtained 59fe dissappearance and appearance curves were analyzed. the analyses were based on a 5-compartmental system. alternative m ...	1977	264050
transfer and dynamics of uric acid in the pregnant rhesus monkey. i. transplacental and renal uric acid clearances.	data from the literature suggest that uric acid produced by the fetus could pass across the placenta and contribute to the observed increase in maternal plasma levels of uric acid in preeclamptic pregnancy. to investigate this hypothesis, fetal transplacental and renal uric acid clearances were estimated in 4 term pregnant rhesus monkeys by means of the steady infusion method using 14c-labeled uric acid. allantoin clearances were determined in one pregnant monkey. samples of maternal and fetal a ...	1978	264165
transfer and dynamics of uric acid in the pregnant rhesus monkey. ii. a mathematical model.	the objective of the present study was to develop a mathematical model of the dynamics of uric acid between fetal and maternal compartments in the term pregnant rhesus monkey. in 3 different animals 14c-labeled uric acid was injected into the fetal circulation, the amniotic fluid and the maternal circulation, respectively. in one experiment no uric acid was administered and the fetus was deliberately killed at the beginning of the experiment. samples of fetal and maternal blood, maternal urine a ...	1978	264166
structural heterogeneity of c2 complement protein and its genetic variants in man: a new polymorphism of the hla region.	a zymogram method, following thin-layer isoelectric focusing in a polyacrylamide gel, allows resolution of the lytic activity of serum c2 complement protein in a spectrum of molecular forms. this spectrum is characteristic in each of the species studied (man, rhesus monkey, guinea pig, and hamster). moreover, two different alternative patterns are observed in man: each of the six major lytic bands characteristic of the most common pattern (herein designated c2(1) is duplicated in the least commo ...	1977	266206
long bone osteosarcoma in a rhesus monkey.		1979	293317
concomitant strabismus and cortical eye dominance in young rhesus monkeys.	optical dissociation of the visual images produces a loss of binocular cells at the striate cortex. young monkeys wearing base-in prisms lose 50 per cent of their cortical binocular cells within 30 days. exposure to visually redundant stimulation inside a striped cylinder while wearing the dissociating prisms does not prevent the loss of binocular cells. once lost, a subsequent period of normal binocular viewing experience up to 3 months in duration does not result in significant recovery of bin ...	1979	298815
trialwise tracking method for measuring drug-affected sensory threshold changes in animals.	rats and rhesus monkeys were trained under a multiple schedule, the components of which were random ratio schedules for food presentation and for shock presentation. the discriminative stimulus for the shock presentation component was a pure tone for the rats and a light for the rhesus monkeys. in the test session under the extinction condition for the shock presentation component, the intensity of the discriminative stimulus was successively either decreased by fixed units when the conditioned ...	1979	299584
primate model for the study of in vitro--in vivo immunologic monitoring correlates: studies of in vitro correlates of rejection in rhesus monkeys treated with clinical atg.		1978	309672
the use of a continuous cell line for the isolation of influenza viruses.	cultures of mdck cells exposed to trypsin were as efficient as cultures of rhesus monkey kidney cells for detecting influenza virus, both in dilutions of infected allantoic fluids and in nose and throat swabs. we suggest that the mdck cell/trypsin system provides a satisfactory alternative to monkey kidney cultures for the isolation of influenza viruses from clinical specimens.	1978	310738
cerebral color blindness: an acquired defect in hue discrimination.	in contrast to the traditional view that striate visual cortex (area 17) is surrounded by two homogeneous cortical areas (areas 18 and 19), recent studies have shown that mammalian extrastriate visual cortex contains several anatomically and functionally distinct subregions. one such region, the v-4 complex of the rhesus monkey, is highly specialized for the analysis of color information, suggesting that a lesion in a homologous region might produce a defect in color vision while sparing other v ...	1979	312619
canine hemorrhagic enteritis: detection of viral particles by electron microscopy.	at necropsy, several dogs which died showing symptoms of hemorrhagic diarrhea, had significant lesions of the mucosa that were found especially in the duodenum and upper part of the small bowel. study of ultrathin sections from the diseased mucosa revealed particles resembling parvoviruses in altered nuclei of cells of the intestinal crypts. electron microscopic examination of intestinal contents by negative staining has shown the presence of many viral particles which have a diameter of 24 nm a ...	1979	316320
hounding the pill.	drug toxicity testing is required by the u.s. food and drug administration in bitches of beagle dogs for 7 years and in female rhesus monkeys for 10 years at 25-50 times the human dosage. progesterone, medroxyprogesterone acetate, megesterol acetate, chlormadinone acetate, chloroethynl norethisterone and chloroethynyl norgestrel are some compounds which have induced tumors in beagle dogs. however, the endocrinology of the beagles is unlike that of a woman and binding affinity of synthetic prog ...	1979	318466
cns lead toxicity in rabbit offspring.	an animal model for asymptomatic and overt lead toxicity is presented in which rabbit pups, 1 to 30 days of age, were fed a milk supplement containing pb(no3)2. reduced body growth, increased mortality, hematologic abnormalities, kidney and liver histopathology, as well as encephalopathy, were observed in rabbits 2 to 30 days of age ingesting more than 2.8 mg of pb/day. at the highest dose, brain lesions were widespread, involving the frontal and occipital cortex, striatum, hippocampus, and cere ...	1978	318502
immunologic surface markers on nonhuman primate lymphocytes.	peripheral blood lymphocytes from 37 healthy rhesus macaques (macaca mulatta) and thymocytes from 10 fetal and neonatal rhesus macaques were studied for membrane characteristics. spontaneous rosette formation with sheep erythrocytes, a characteristic of human t lymphocytes, was evaluated. the presence of membrane-bound immunoglobulin and surface receptors for fixed complement was measured, using fluorescent antibody techniques and erythrocyte-antibody-complement rosettes, respectively. the mean ...	1977	322554
t and b cell populations in the peripheral blood of rhesus monkeys.	b and t cell populations in the peripheral blood of rhesus monkeys are comparable to those of normal human beings. b cells of monkeys, like those of human beings, also have receptors for igm, igg and iga.	1977	323153
resolution of antimalarial agents via complex formation with alpha-(2,4,5,7-tetranitro-9-fluorenylideneaminooxy) propionic acid.	the resolution of several antimalarial agents via pi-complex formation with alpha-(2,4,5,7-tetranitro-9-fluorenylideneaminooxy) propionic acid (tapa) is reported. since this represents the first use of this agent for the resolution of amines, some details of the separations are presented. the method proved successful for resolving weakly alkaline amines that did not form stable salts with common resolving acids, highly insoluble amines that did not form soluble salts with usual resolving acids, ...	1978	349156
monoamine-containing paraneurons in the sympathetic ganglia of mammals.	1. a combined method for glyoxylic acid induced catecholamine fluorescence and electron microscopy was introduced in this study of the small intensely fluorescent (sif) or granule-containing (gc) cells of the sympathetic ganglia. 2. adrenergic interneurons were demonstrated in the sympathetic ganglia of the rat and the rhesus monkey. 3. existence of adrenergic paraneurons (neuro-endocrine cells) in the sympathetic ganglia of several mammalian species was suggesed by the following observations: a ...	1977	354578
hypothesis: placental membranes produce prolactin.	orthodox views for the origin of the high concentration of prolactin (prl) present in amniotic fluid suggest it is derived from maternal or fetal serum. however, the data on which these conclusions are based can also be interpreted to indicate that this hormone may be a product of placental or periplacental tissues. trophoblast or amnion do not appear to produce prl, while prl synthesis by decidua-chorion is suggested from experiments in the rhesus monkey and by in vitro incubation of human tiss ...	1978	355008
identification of the lh and tsh-secreting cells in the pituitary gland of the rhesus monkey.	pituitary glands from juvenile (pre-pubertal) and adult male and female rhesus monkeys were examined following immunocytochemical staining with antisera to the beta subunits of ovine luteinizing hormone (lhbeta) and of human thyroid stimulating hormone (tshbeta). the lhbeta antiserum reacts with a cell that is pas-positive, occurs singly and is randomly distributed throughout the pars distalis. the diameter of these cells is approximately 11.5 micrometer. they do not seem to vary in number in ei ...	1978	357001
chronic pyelonephritis. electron microscopic study. ii. persistence of variant bacterial forms.	ascending nonobstructive pyelonephritis was produced in nonhuman primates by ureteral catheterization which delivered escherichia coli (04:h1) to the renal pelvis while creating intrarenal reflux. female rhesus monkeys (macaca mulatta) were immunosuppressed by cyclophosphamide before infection and weekly thereafter and compared to those with infection only. kidney tissue was examined by electron microscopy in an effort to compare the development of the infection in the two groups of monkeys, i.e ...	1978	361629
neuronal migration and contact guidance in the primate telencephalon.	over the last decade, evidence from experimental studies on neuronal migration in non-human primates has accumulated to the point where it can significantly amplify our understanding of the normal and pathological development of the human telencephalon. systematic analysis of neuron genesis by the method of h3-thymidine autoradiography shows that in rhesus monkeys all neurons destined for the neocortex are generated near the surface of the lateral ventricle during a two-month period in the middl ...	1978	364453
endocrine properties and clinical application of danazol.	danazol, a heterocyclic steroid related chemically to 17 alpha-ethinyltestosterone (ethisterone), is currently approved by the fda for treatment of endometriosis only. however, other clinical applications of the drug may be found for both endocrine and nonendocrine disorders. hence, the literature of danazol is reviewed. included are discussions of the chemical structure and biological properties of danazol, which has a basic cyclopentenophenanthrene configuration characteristic of all steroi ...	1979	374128
precoital single doses of delta9-tetrahydrocannabinol block ovulation in the rabbit.	delta9-tetrahydrocannabinol (delta9-thc) inhibits pituitary gonadotropin secretion in castrated rhesus monkeys. also, delta9-thc blocks the ovulatory reflux in rabbits. we report now the dose-response relationship of precoital single doses of delta9-thc on luteinizing hormone (lh) release and ovulation in the rabbit. forty-five female rabbits in estrous were divided into nine groups of five animals. groups 1 to 5 received a single intramuscular dose of delta9-thc (5,2.5, 1.25, 0.612, and 0.306 m ...	1979	374129
isolation of influenza virus from muscle in myoglobinuric polymyositis.	we report the first isolation of influenza virus from muscle in a man with myoglobinuria and acute polymyositis. influenza virus was isolated from cultures of madin darby bovine kidney and primary rhesus monkey kidney cells inoculated with muscle homogenates in the presence of trypsin; the virus was identified by neutralization and hemagglutination inhibition studies using influenza b/lee antiserum. viral plaque assay was performed with madin darby canine cells. viral antigen was also detected b ...	1979	384294
[neural regulation of the reproductive function in the rhesus monkey].		1979	399425
chorionic gonadotropin, chorionic somatomammotropin, and prolactin in the uterine vein and peripheral plasma of pregnant rhesus monkeys.	seven adult female rhesus monkeys were laparotomized at days 22, 42, and 157 of pregnancy and blood was collected from the uterine vein and peripheral circulation. plasma samples were analyzed for monkey chorionic gonadotropin (mcg), monkey chorionic somatomammotropin (mcs), and prolactin by radioimmunoassay. levels of mcg at day 22 of pregnancy were approximately 250 ng/ml; however, during the later stages of gestation mcg was either nondetectable or less than 0.7 ng/ml. there was no statistica ...	1977	401030
immunoreactive lh-like substances in serum of hypophysectomized and prepubertal monkeys: inactive in an in vitro lh bioassay.	serum lh levels in rhesus monkeys are commonly measured by a radioimmunoassay (ria) utilizing ovine lh as the radioligand and a novel antiserum to ovine lh. although meeting most criteria of validity, this ria cross-reacts with serum from demonstrably hypophysectomized monkeys as well as serum from pre-pubertal monkeys. we have utilized the recently developed rat interstitial cell-testosterone assay (rict) for measurement of serum lh in rhesus monkeys during various endocrine states and have com ...	1977	401031
stimulation of testosterone production in vivo and in vitro in the male rhesus monkey fetus in late gestation.	to assess intrauterine fetal testicular function, the carotid or femoral vessels of rhesus monkey fetuses, 129-145 days gestational age, were catheterized following hysterotomy of the mother. the fetus was returned to the uterus, the catheters were exteriorized through the mother's vagina and the pregnancy was allowed to continue. in this chronic preparation, basal levels of testosterone (measured with an ria with 65% cross-reactivity with 5 alpha-dihydrotestosterone) in male fetal serum were 0. ...	1977	401362
frontal decortication in rhesus monkeys: a test of the interference hypothesis.	four monkeys with dorsolateral frontal ablations and 3 unoperated controls were run on discrimination problems which sequentially presented both relevant and irrelevant visual stimuli prior to the opportunity for a choice response. as previously reported, monkeys with undamaged brains performed significantly better on those problems presenting relevant information first, being unaffected by later occurring irrelevant stimuli. contrary to the behavior of the normal monkeys, monkeys with lesions o ...	1977	401465
morphological organization of catecholamine terminals in the diencephalon of the rhesus monkey.	the hypothalamus and thalamus of the rhesus monkey were investigated using the fluorescence histochemical method of falck and hillarp. the hypothalamus was found to be richly supplied with catecholamine fluorescent nerve terminals with many thick and a few varicosities, whereas nerve terminals with fine varicosities were found to be distributed over the thalamus except for the midline and medial nuclei which were innervated by nerve terminals with thicker and more intense fluorescent varicositie ...	1977	401466
central vision of man and macaque: cone and rod sensitivity.	the distribution of photopic and scotopic sensitivity of the rhesus monkey has been described for central vision and compared to sensitivities of human observers. for small, brief, greeen and red test flashes the monkey's sensitivity was comparable to man, but was considerably more sensitive than man's to small, blue (450 nm) test flashes. this superior photopic sensitivity to blue was correlated with a low density of macular pigment. the scotopic sensitivities of man and monkey were comparable ...	1977	401467
distribution and degradation of [3h]methotrexate after intravenous and cerebral intraventricular injection in primates.	four hr after either a single injection or continuous infusion of methotrexate (mtx) plus purified [3',5',9(n)-3h]mtx in cynomolgus or rhesus monkeys, 80 to 98% of the 3h radioactivity present in the plasma was found not to represent intact mtx. the percentage of 3h-containing mtx products in the urine after 4 hr was considerably less, although more variable. this variability seemed to be related to variability in the amount of the total dose excreted. non-mtx products were also found in selecte ...	1977	401470
high-pressure liquid chromatography analysis of benzo(a)pyrene metabolism by microsomal enzymes from rhesus liver and lung.	the metabolism of benzo(a)pyrene was determined, using rhesus monkey hepatic and pulmonary microsomal enzymes. metabolites were separated by high-pressure liquid chromatography and identified using known reference standards. metabolites were quantitated by scintillation spectrometry. both liver and lung microsomes metabolized benzo(a)pyrene to the following metabolites: 9,10-, 7,8-, and 4,5-dihydrodihydroxybenzo(a)pyrene; benzo(a)pyrene-1,6-dione, -3,6-dione, and -6,12-dione; and 9- and 3-hydrox ...	1977	401471
regulation of folliculogenesis in the cycling rhesus monkey: selection of the dominant follicle.	to identify factors regulating the initiation of follicle growth in adult primates, the ovarian cycle of sexually mature rhesus monkeys was interrupted by surgical ablation of the preovulatory follicle or functioning corpus luteum (cl). in 10 of 10 animals, cautery of the largest visible follicle on day 8-12 of the cycle blocked ovulation, and in all but one abolished the expected midcycle surges of gonadotropin secretion. in 8 monkeys of this group, surges of lh and fsh release occurred 12.4 +/ ...	1977	401483
effects of estrogen on thyroxine-binding globulin metabolism in rhesus monkeys.	to investigate the effects of estrogen on thyroxine-binding globulin (tbg) metabolism, 4 female rhesus monkeys were studied before and 3-4 weeks after implantation of beta-estradiol (e2)-containing capsules. in addition, 2 of the animals were also studied for the first 7 days after the start of e2. serum e2 increased 10-fold from 20 +/- 7 to 212 +/- 41 pg/ml. serum tbg, initially 20.2 +/- 6 mug/ml, was elevated by 24 h after e2 implantation, and reached a steady level of 46.8 +/- 5.0 mug/ml by 7 ...	1977	401485
hemoperfusion through albumin-conjugated agarose gel for the treatment of neonatal jaundice in premature rhesus monkeys.	hemoperfusion through albumin-conjugated agarose gel (aag) effectively removes bilirubin (br) and other albumin-bound materials from whole blood or plasma. we have used this technique to treat neonatal jaundice in premature rhesus monkeys with a specially designated apparatus which permits continuous perfusion through one of four columns arranged in parallel while the others are sequentially washed with saline and regenerated with ethanol. less than 15 per cent of the animal's blood volume is re ...	1977	401515
the use of calcium chelating agents and prostaglandin e to eliminate platelet and white blood cell losses resulting from hemoperfusion through uncoated charcoal, albumin-agarose gel, and neutral and cation exchange resins.	hemoperfusion through adsorbents such as charcoal, cation exchange (e.g., ag 50w-x8) and uncharged (e.g., xad-2) resins, and albumin-agarose gel (aag) has been proposed for use in patients with hepatic failure. however, the loss of white blood cells and, particularly, platelets caused by each of these adsorbents remains a major deterrent to their clinical use. in vitro studies demonstrate that addition of citrate, ethylenediamine tetraacetate (edta), or oxalate to heparinized human blood elimina ...	1977	401516
pulp response to enamelite restorations in teeth of rhesus monkeys.	the average magnitudes of cellular displacements, superficial responses, and deep responses were less for specimens restored with zoe than for enamelite specimens at the 1 week postoperative period. of 20 teeth treated, three abscesses were found in the 1 week enamelite postoperative period when the remaining dentin was 0.3 mm. or less. this indicates the presence of ingredients that are toxic to the pulp when there is little remaining dentin or when the material is placed directly over an expos ...	1977	401527
short term morphologic effects of high ambient levels of ozone on lungs of rhesus monkeys.	groups of laboratory-reared, young adult rhesus monkeys were exposed to 0.8 p.p.m. or 0.5 p.p.m. of ozone for 8 hours a day on 7 consecutive days. lesions were studied using correlated techniques which permitted examination of specified levels of airways and adjacent lung parenchyma by light microscopy, scanning electron microscopy, and transmission electron microscopy. lesions were observed in the trachea and lungs of all exposed animals. the extent and severity of damage, but not its nature, v ...	1977	401528
a comparison of two- and four-stage ablations of sulcus principals on recovery of spatial performance in the rhesus monkey.		1977	401532
insulin, glucagon, and glucose exhibit synchronous, sustained oscillations in fasting monkeys.	in overnight fasted rhesus monkeys, synchronous, regular oscillations occurred in the plasma concentrations of glucose, insulin, and glucagon. the oscillations displayed a period averaging 9 minutes. the amplitudes for insulin and glucagon were ten and five times greater than for glucose. insulin cycled in and glucagon out of phase with glucose. in baboons, oscillations of glucose and insulin were smaller than in rhesus monkeys, while in man, regular oscillations were not observed.	1977	401543
effects of fetal or maternal hypophysectomy on endocrine organs and body weight in infant rhesus monkeys (macaca mulatta): with particular emphasis on oogenesis.		1977	401655
prolactin release following electrical stimulation of the brain in ovarectomized and ovariectomized estrogen-treated rhesus monkeys.	selected areas in the medial basal (mbh) and rostral (rh) hypothalamus and in the amygdala (amyg) of long-term ovariectomized rhesus monkeys were electrically stimulated for 30 min through permanently implanted bilateral stainless steel electrodes. stimulation of an area in the mbh extending from the dorsal part of the ventromedial nucleus through the arcurate nucleus to the upper median eminence resulted in a 200 to 400% increase within 5 min in 8 monkeys. in one monkey the elevated serum prola ...	1977	401729
gonadotropin-sensitive progesterone production by rhesus monkey luteal cells in vitro: a function of age of the corpus luteum during the menstrual cycle.	progesterone production in vitro, in the presence and absence of exogenous gonadotropin, was examined in suspensions of luteal cells, isolated by collagenase digestion of rhesus monkeys corpus luteum at various stages of the menstrual cycle. cells isolated during mid-luteal phase (days 15-19) of the cycle secreted progesterone for up to 6 h in vitro. mid-luteal phase cells were responsive to physiologic concentrations of human chorionic gonadotropin (hcg), with progesterone production significan ...	1977	401732
amniotic prolactin control over amniotic and fetal extracellular fluid water and electrolytes in the rhesus monkey.	administration of 1-10 mg ovine pituitary prolactin (oprl) into the amniotic fluid of 10 rhesus monkeys in the last third of gestation consistently caused a decrease in amniotic fluid volume not seen when saline, vasopressin, or bovine serum albumin were injected into 9 other monkeys. the effects lasted for 24 h. intraamniotic injection of 10 mg oprl prevented or reversed a doubling of water and electrolyte content of the fetal extracellular fluid (ecf) volume in the face of hypertonic amniotic ...	1977	401734
influence of vasopressin on colon blood flow in monkeys.	inferior mesenteric arterial blood flow was measured with an electromagnetic blood flowmeter in five anesthetized rhesus monkeys. the effects of vasopressin on this vasculature were determined to evaluate the optimal, safe concentration of this agent during its clinical application in the management of hemorrhagic lesions of the colon. control flow was 29 +/- 3 (se) ml min-1; aortic pressure was 124 +/- 4 mm hg. intraarterial injections of vasopressin, in doses ranging logarithmically from 5 x 1 ...	1977	401750
influence of anesthetics, ethyl alcohol, and freon on dark adaptation of monkey cone erg.	cone dark adaptation curves were measured in a rhesus monkey using the electroretinogram (erg) response to a 40 hz flickering stimulus. the influence of anesthetics on the time course of dark adaptation was studied. all volatile anesthetics tested (methoxyflurane, halothane, enflurane, ether, chloroform) retarded dark adaptation but to different degrees; urethane, ethyl alcohol, and freon 11 also retarded dark adaptation. no effect was found for barbiturates and ketamine. it seems unlikely that ...	1977	401778
thalamic projections of the superior colliculus in the rhesus monkey, macaca mulatta. a light and electron microscopic study.	the projections of the superior colliculus to the thalamus have been studied in the monkey, macaca mulatta, with anterograde degeneration techniques. the superior colliculus has been shown to project to the inferior nucleus of the pulvinar in a topographical manner with the lower visual field represented dorsomedially and the upper field ventrolaterally. the peripheral zone is located along the medial border and the fovea at the dorsolateral angle adjacent to the lateral geniculate nucleus. the ...	1977	401837
an intricately patterned prefronto-caudate projection in the rhesus monkey.	the distribution of prefronto-caudate fibers in the caudate nucleus was studied autoradiographically in monkeys of various ages in which tritiated amino acids had been injected into the middle one-third of the length of the dorsal bank of the principal sulcus. the results indicate that, contrary to previous reports which had suggested a projection to only the head of the caudate nucleus, area 9 of brodmann projects to the entire length of the nucleus. in the head of the caudate nucleus the corti ...	1977	401838
immunogenetic studies of rhesus monkeys. vii. a simple hemagglutination technique for blood typing.	a microtiter hemagglutination technique was adapted for routine blood typing of rhesus monkeys. the main advantage of the technique is economy of scarce reagents, since they can be used at greater dilutions and in smaller quantities than in the standard tube technique. furthermore, the technique is sensitive, accurate, and easy to perform.	1977	401848
spleen function in quartan malaria (due to plasmodium inui): evidence for both protective and suppressive roles in host defense.	for investigation of the role of the spleen in host defense and chronicity in quartan malaria, the course of plasmodium inui infection was studied in 39 intact rhesus monkeys, 16 monkeys splenectomized before infection, and 22 monkeys splenectomized after infection. splenectomized animals consistently had peak parasitemias greater than 10-fold higher than those of intact animals, but the mortality rate at peak parasitemia was only higher in monkeys splenectomized before infection. whereas intact ...	1977	401854
role of striate cortex and superior colliculus in visual guidance of saccadic eye movements in monkeys.	1. we studied the effect of lesions placed in striate cortex or superior colliculus on the detection of visual stimuli and the accuracy of saccadic eye movements. the monkeys (macaca mulatta) first learned to respond to a 0.25 degrees spot of light flashed for 150-200 ms in one part of the visual field while they were fixating in order to determine if they could detect the light. the monkeys also learned in a different task to make a saccade to the spot of light when the fixation point went out, ...	1977	401874
biological effects of cocaine derivatives i: improved synthesis and pharmacological evaluation of norcocaine.	an improved synthesis of norcocaine, a metabolite of cocaine, is reported. following intravenous administration to a rhesus monkey, respiratory effects were similar to those observed following cocaine treatment. in addition, clonic convulsions, hypothermia, and mydriasis resulted. norcocaine could be responsible for part of the pharmacological activity of cocaine.	1977	401881
phospholipids and phospholipid-bound fatty acids and aldehydes of spermatozoa and seminal plasma of rhesus monkeys.	the major components of the phospholipids of rhesus monkey spermatozoa are phosphatidyl choline (33%), phosphatidyl ethanolamine (25%), ethanolamine plasmalogen (16-1%), sphingomyelin (8-1%), choline plasmalogen (6-9%) and cardiolipin (4-5%). the major phospholipid-bound fatty acids are 16:0, 18:0, 18:1 and 22:6; the major fatty aldehydes are 15:0, 16:0 and 18:2. the same phospholipids are also present in the seminal plasma.	1977	401884