Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| regulation and localization of estrogen and progestin receptors in the pituitary of steroid-treated monkeys. | prl increases during pregnancy in primates with rising levels of placental estradiol (e) and progesterone (p). however, while e will increase prl secretion in monkey pituitary cell cultures, p has no effect. we recently localized progestin receptors (pr) to gonadotropes, but not lactotropes, with an immunocytochemical technique to double stain monkey pituitary cell cultures. the following studies were performed to confirm the immunocytochemical localization of pr in intact pituitary tissue and t ... | 1990 | 2298155 |
| stimulation of cell division by argon and nd:yag laser trabeculoplasty in cynomolgus monkeys. | although laser treatment of the trabecular meshwork is the most common form of surgery for glaucoma, the tissue response to this therapy is still incompletely understood. we applied argon or nd:yag laser to the trabecular meshwork of six monkeys. cell division was identified by injecting tritiated thymidine into the anterior chamber 24 hr after laser application. autoradiography of tissue sections revealed significantly more labelled cells in eyes treated with laser than in the untreated control ... | 1990 | 2298532 |
| oral contraceptives and coronary artery atherosclerosis of cynomolgus monkeys. | studies of both human and nonhuman primates show an inverse relationship between high-density lipoprotein (hdl) cholesterol concentrations and coronary artery atherosclerosis. for this reason, there has been concern that the hdl cholesterol-lowering effect of oral contraceptives might exacerbate coronary artery atherosclerosis. we studied three groups of adult female cynomolgus macaques fed a moderately atherogenic diet: a control group, a group given ethinyl estradiol and norgestrel, and anothe ... | 1990 | 2300348 |
| functional orthopedic magnetic appliance (foma) iii--modus operandi. | an intraoral intermaxillary appliance has been developed for the treatment of class iii malocclusions that exhibit midface sagittal deficiency with or without mandibular excess. the functional orthopedic magnetic appliance (foma) iii consists of upper and lower acrylic plates with a permanent magnet incorporated into each plate. the upper magnet is linked to a retraction screw. the upper magnet is retracted periodically (e.g., monthly) to stimulate maxillary advancement and mandibular retardatio ... | 1990 | 2301300 |
| effects and interactions of epinephrine, norepinephrine, timolol, and betaxolol on outflow facility in the cynomolgus monkey. | total outflow facility was determined in cynomolgus monkeys by two-level constant pressure perfusion. topical epinephrine increased facility by 30% to 35% three to four hours after dosing, whether given as a single 600-micrograms dose or as twice daily 600-micrograms doses for three days. a single 5.5-micrograms intracameral dose of epinephrine or norepinephrine increased facility by 65% to 70% three to four hours after dosing. a single 180-micrograms topical dose of timolol or betaxolol had no ... | 1990 | 2301530 |
| ebola virus infection in imported primates--united states. | in late november 1989, ebola virus was isolated from cynomolgus monkeys (macaca fascicularis) imported into the united states from the philippines via amsterdam and new york. during quarantine in a primate facility in virginia, numerous macaques died, some with findings consistent with simian hemorrhagic fever (shf). the us army medical research institute of infectious diseases tested 10 animals and, from 3, isolated shf from tissues and serum; however, 5 other animals of the 10 tested were posi ... | 1990 | 2302743 |
| [a comparison of hematological and serum biochemical values between two groups of female cynomolgus monkeys reared under different conditions]. | the influence of long term rearing conditions on the hematological and serum biochemical values in laboratory-bred female cynomolgus monkeys (macaca fascicularis) was studied under the following two conditions. group a: new born infants were nursed by their mothers for at least 12 weeks after birth. after weaning, four monkeys of approximately equal age and body weight were kept in a relatively small cage (90 cm w x 60 cm d x 60 cm h) and reared to five years of age. these rearing conditions are ... | 1990 | 2303091 |
| serum immunoreactive inhibin levels before and after luteectomy in the cynomolgus monkey (macaca fascicularis). | whereas studies in women have demonstrated that serum immunoreactive inhibin concentrations peak during the luteal phase of the menstrual cycle and that the corpus luteum (cl) encodes mrna for the inhibin subunits, a clear link between the presence of the cl and circulating inhibin has not been established in primates. therefore, we measured serum immunoreactive inhibin levels in monkeys before and after luteectomy as well as immunoreactive inhibin concentrations and mrna encoding the alpha-inhi ... | 1990 | 2307721 |
| the thromboxane receptor antagonist sq 30,741 reduces myocardial infarct size in monkeys when given during reperfusion at a threshold dose for improving reflow during thrombolysis. | the threshold dose of the selective thromboxane receptor antagonist sq 30,741 for increasing reflow during thrombolysis was identified and then evaluated in a model of myocardial ischemia with reperfusion. in anesthetized cynomolgus monkeys, stenotic carotid arteries were occluded with a platelet-rich thrombus by electrical stimulation and recanalized with streptokinase (680 u/min intraarterially for 1 h) and heparin (200 u/kg + 120 u/h intravenously for 3 h). concurrent administration of sq 30, ... | 1990 | 2307799 |
| age-related changes of the ciliary muscle in comparison with changes induced by treatment with prostaglandin f2 alpha. an ultrastructural study in rhesus and cynomolgus monkeys. | the relationship between individual ciliary muscle cells and the surrounding connective tissue was studied in the eyes of three normal, young (3-4 years) cynomolgus monkeys (macaca fascicularis), three aged (34-36 years) rhesus monkeys (macaca mulatta) and seven young (3-7 years) cynomolgus monkeys topically treated with prostaglandin f2 alpha (pgf2 alpha) for 4-8 days. in normal eyes, collagen fibrils and microfibrils are in places in continuity with the muscle cells' basal lamina, which is con ... | 1990 | 2308387 |
| effects of atherosclerosis on the coronary microcirculation. | we tested the hypothesis that atherosclerosis potentiates coronary vasoconstriction to serotonin and ergonovine. coronary microvascular pressures and diameters were measured in the beating left ventricle in normal and atherosclerotic cynomolgus monkeys. pressures were measured in arteries (190-350 microns diam) that were distal to atherosclerotic lesions. microvascular pressure and simultaneous measurements of aortic pressure and myocardial blood flow were used to calculate segmental vascular re ... | 1990 | 2309917 |
| ciliary neuromuscular morphology in cynomolgus monkeys after ciliary ganglionectomy. | cynomolgus monkeys underwent unilateral ciliary ganglionectomy (cg) and/or posterior ciliary neurectomy (pcn). the ciliary muscle was functionally denervated, as evidenced by loss of choline acetyltransferase activity, loss of the accommodative response to topical eserine and electrical stimulation of the edinger-westphal nucleus, and supersensitivity of the accommodative response to pilocarpine. light and electron microscopy carried out 3-28 days after cg/pcn revealed degeneration of myelinated ... | 1990 | 2311945 |
| cryopreservation of cynomolgus monkey (macaca fascicularis) hepatocytes for subsequent culture and protein synthesis studies. | a method is described for the preservation and subsequent recovery of hepatocytes obtained by collagenase perfusion of cynomolgus monkey (macaca fascicularis) livers. the fresh cells are suspended in fetal bovine serum containing 10% dimethylsulfoxide and, using a microprocessor-controlled, liquid nitrogen freezing chamber and a specific cooling protocol, processed in such a way that they can be stored in liquid nitrogen for several months and still restored to active culture. when the cryoprese ... | 1990 | 2312497 |
| methylmercury effects on the social behavior of macaca fascicularis infants. | observations of the social behavior of macaca fascicularis exposed in utero to methylmercury (mehg) and nonexposed control infants were performed as part of a study of the toxic, reproductive and developmental effects of maternal mehg intake. infants were tested twice weekly from 2 weeks to 8 months of age. data were summarized into 6 categories of social behavior and 7 categories of nonsocial behavior. analysis of the most prevalent behavior indicated that mehg-exposed offspring exhibited a dec ... | 2015 | 2314361 |
| the ocular hypotensive effect of the topical carbonic anhydrase inhibitor l-671,152 in glaucomatous monkeys. | l-671,152, a new potent water-soluble inhibitor of human carbonic anhydrase ii in vitro, was applied topically to cynomolgus monkey eyes in which glaucoma had been produced by argon laser photocoagulation of the trabecular mesh-work. intraocular pressure was measured at 0 hours, 0.5 hours, and hourly for 8 hours in eight eyes for 2 baseline days, 1 day receiving the vehicle and 5 days receiving therapy with 2% l-671,152 twice a day, after initial single-dose trials of various concentrations. int ... | 1990 | 2322152 |
| long-term comparative study of the schocket and joseph glaucoma tube shunts in monkeys. | schocket and joseph tube shunts were implanted in normal cynomolgus monkey eyes in order to compare the tissue response to the shunts as well as the pathways of aqueous flow associated with each. following periods ranging from 5 to 10 months after implantation horseradish-peroxidase and/or fluorescein-labelled latex microspheres were inserted into the anterior chamber. the monkeys were then killed and the eyes studied by light, scanning, and transmission electron microscopy. in general, tissue r ... | 1990 | 2325995 |
| a primate model of anterior segment ischemia after strabismus surgery. the role of the conjunctival circulation. | fornix conjunctival incisions in strabismus surgery may provide partial protection against anterior segment ischemia by preserving the perilimbal conjunctival-tenon's circulation, which is disrupted with limbal conjunctival incisions. six adult cynomolgus monkeys underwent tenotomies of three or four rectus muscles by making limbal conjunctival incisions in one eye and fornix incisions in the other. iris fluorescein angiography and slit-lamp biomicroscopy were used to monitor changes. the eyes t ... | 1990 | 2326023 |
| the relationship of retrobulbar hematomas to vision in cynomolgus monkeys. | an experimental model has been developed to measure the effect of retrobulbar hematomas on functional vision in cynomolgus monkeys. in this model, functional vision was quantitated using flashed evoked visual potentials in five monkeys following creation of retrobulbar hematomas. in one monkey used as a control, functional vision remained impaired for 180 minutes following induction of retinal ischemia by increased intraorbital pressure. in two monkeys in which increased intraorbital pressure wa ... | 1990 | 2326352 |
| in vivo effects of recombinant human interleukin-6 in primates: stimulated production of platelets. | in cynomolgus monkeys, twice daily subcutaneous injections of recombinant human interleukin-6 (rhil-6) at doses of 5 to 80 micrograms/kg/d for 14 consecutive days caused dose-dependent increases in platelet count, usually continuing for more than 1 week after cessation of the injections. the count reached a level approximately twofold or more above the preinjection level even at 5 micrograms/kg/d, and at doses of more than 20 micrograms/kg/d, the increase became biphasic with a higher second pea ... | 1990 | 2328312 |
| ovarian oxytocin and neurophysin concentrations in the cynomolgus monkey (macaca fascicularis). | the neurohypophysial hormone oxytocin has previously been found in the ovaries of several animal species. in ruminants ovarian oxytocin is postulated to have a luteolytic function, because of its high concentrations in the corpus luteum. in primates the role of ovarian oxytocin is not known. in the present study we measured the immunoreactive oxytocin and oxytocin-neurophysin content in paired ovaries removed from cynomolgus monkeys (macaca fascicularis) during the late luteal phase of the cycle ... | 1990 | 2328707 |
| musculotopic organization of the facial motor nucleus in macaca fascicularis: a morphometric and retrograde tracing study with cholera toxin b-hrp. | morphometric and retrograde tracing methods were used to determine the location and number of motoneurons innervating individual facial muscles in macaca fascicularis. intramuscular injections of the cholera toxin b subunit-horseradish peroxidase conjugate produced discrete labeling patterns in the ipsilateral facial motor nucleus with good definition of somata and their processes. the facial nucleus extended rostrocaudally in the pons for about 2 mm, varying in shape and cross-sectional area al ... | 1990 | 2329193 |
| autoradiographical detection of cholecystokinin-a receptors in primate brain using 125i-bolton hunter cck-8 and 3h-mk-329. | in vitro autoradiography was performed in order to visualize cholecystokinin-a (cck-a) receptors in sections of cynomolgus monkey brain. cck-a receptors were defined as those which displayed high affinity for the selective non-peptide antagonist mk-329 (l-364,718) and were detected in several regions by selective inhibition of 125i-bolton hunter cck using mk-329 or direct labeling with 3h-mk-329. in the caudal medulla, high densities of cck-a sites were present in the nucleus tractus solitarius, ... | 1990 | 2329368 |
| improved biocompatibility of intraocular lenses by heparin surface modification: a 12-month implantation study in monkeys. | to evaluate the long-term biocompatibility and potential side effects of heparin surface modification of a poly(methyl methacrylate) intraocular lens (iol), a heparin surface modified iol was implanted in the left posterior chamber of 24 cynomolgus monkeys and a reference iol (without surface modification) was implanted in the right eye in 12 of these animals. twelve eyes were not operated on. eleven eyes in seven monkeys were lens extracted as a control of the surgical method. slitlamp examinat ... | 1990 | 2329473 |
| lack of sensitive period for lead-induced behavioral impairment on a spatial delayed alternation task in monkeys. | a total of 52 monkeys (macaca fascicularis) were dosed orally with vehicle or 1.5 mg/kg/day of lead on one of four dosing regimens (13 monkeys/group): vehicle only; dosed with lead from birth onward; dosed with lead from birth to 400 days of age and vehicle thereafter; dosed with vehicle from birth to 300 days of age and lead thereafter. blood lead concentrations averaged 3-6 micrograms/dl when monkeys were not being dosed with lead, 32-36 micrograms/dl when being dosed with lead and having acce ... | 1990 | 2330594 |
| a refractive and histopathologic study of excimer laser keratectomy in primates. | using a 193-nm excimer laser, we produced wide-area, refractive keratectomies on 18 cynomolgus monkey corneas and followed them up for up to 18 months. all corneas developed some subepithelial haze by one month. electron microscopy disclosed epithelial thickening, absence of bowman's layer, and subepithelial activated fibroblasts surrounded by disorganized collagen. by six months, the haze faded to a variable degree, the epithelium regained normal thickness, and the collagen was more organized. ... | 1990 | 2330944 |
| development of immunity to ocular chlamydial infection. | the development of "natural immunity" to homologous and heterologous ocular challenge with chlamydia trachomatis was examined in cynomolgus monkeys given primary or secondary inoculations of c. trachomatis serovars b, c, and e. overall, serovar e gave more severe disease than the other serovars. the amount of disease induced by the 2 serovar b strains examined, tw-5 and har-36, varied. in general, animals showed resistance to homologous secondary challenge, which was better characterized by a re ... | 1990 | 2331044 |
| estrogen modulates responses of atherosclerotic coronary arteries. | although evidence indicates that estrogen replacement therapy reduces risk of coronary heart disease, the mechanism remains unknown. among the possibilities are that estrogen replacement therapy may 1) inhibit growth of atherosclerotic plaque and 2) decrease the prevalence of transient myocardial ischemia and myocardial infarction by modulating vasomotion in atherosclerotic coronary arteries. using quantitative coronary angiography, we determined vasomotor responses of atherosclerotic coronary a ... | 1990 | 2331772 |
| pharmacokinetics and pharmacodynamics of testosterone enanthate and dihydrotestosterone enanthate in non-human primates. | the pharmacokinetics and pharmacodynamics of testosterone enanthate and dihydrotestosterone-enanthate were compared in orchidectomized cynomolgus monkeys (macaca fascicularis) and in intact gnrh agonist-suppressed rhesus monkeys (macaca mulatta). following a single im injection of 32.8 mg testosterone enanthate or 32.7 mg dihydrotestosterone-enanthate, i.e. 23.6 mg of pure steroid, in the orchidectomized cynomolgus monkeys, serum testosterone and dihydrotestosterone levels rose to 400 and 800% o ... | 1990 | 2333732 |
| the effect of mk-927, a topical carbonic anhydrase inhibitor, on iop in glaucomatous monkeys. | mk-927 is a water soluble, potent inhibitor of human carbonic anhydrase (ca) ii in vitro. topical administration of mk-927 reduces intraocular pressure (iop) in rabbits. elevated iop was produced in cynomolgus monkey eyes by argon laser photocoagulation of the trabecular meshwork. iop was measured at 0 hr, 0.5 hr and hourly for 8 hrs in 8 eyes for two baseline days, one day on vehicle and five days of therapy with 2% mk-927 b.i.d., after initial single-dose trials of various concentrations. iop ... | 1990 | 2335112 |
| identification of human acrosomal antigen sp-10 in primates and pigs. | the intra-acrosomal human sperm protein sp-10 was previously designated a "primary vaccine candidate" by a world health organization taskforce on contraceptive vaccines. in the present study, a monoclonal antibody to sp-10 (mhs-10) was employed on western blots to identify immunoreactive sp-10 in sperm extracts from baboon (papio cyanocephalus anubis) and two macaques (macaca mulatta and macaca fascicularis). in each of these primates, the mhs-10 monoclonal antibody recognized a polymorphic patt ... | 1990 | 2337631 |
| ro 23-6457 prolongs survival of vascularized allografts in rodents and primates. | the ability of ro 23-6457, a retinoid compound with marked in vitro immunosuppressive properties, to prolong vascularized allografts was examined in several in vivo transplantation models. in the murine heterotopic heart model, efficacy was shown in two h-2 incompatible strain combinations, with indefinite graft survival at some doses. in the rat heterotopic heart model, oral administration prolonged wistar-furth grafts in lewis hosts an average of 1 week, with no long-term survivors at a variet ... | 1990 | 2338814 |
| estrogen receptor in the ductuli efferentes, epididymis, and testis of rhesus and cynomolgus macaques. | we obtained the testes, ductuli efferentes, and epididymides from adult rhesus and cynomolgus macaques and examined these tissues for estrogen receptors (er) with immunocytochemistry (icc) and a sucrose gradient assay. both techniques employed monoclonal antibodies prepared against er, and both showed that high concentrations of er were present offy in the ductuli efferentes. moreover, all specific staining was confined to the nuclei of the nonciliated, absorptive epithelial cells. the quantity ... | 1990 | 2340336 |
| distal invaginations and the renewal of cone outer segments in anuran and monkey retinas. | although it is now clear that the outer segments of mature vertebrate cones are regularly renewed, it is not known how a cone outer segment can maintain a tapered shape if its narrower tip is periodically lost by shedding. this problem was addressed by morphological examination of photoreceptors in retinas of anurans (xenopus laevis) and monkeys (macaca fascicularis). light microscopy revealed a marked daily change in the shape of cone outer segments in x. laevis: at light offset they were long ... | 1990 | 2340582 |
| post-stenotic core flow behavior in pulsatile flow and its effects on wall shear stress. | arteries of several species, including man, tend to adjust their diameters such that the mean wall shear stress is in the range of 10-20 dynes cm-2. additionally, intimal thickening in the human carotid bifurcation correlates well with the reciprocal of wall shear stress as determined in model studies. the correlation indicates that wherever the local mean wall shear stress exceeds approximately 10 dynes cm-2, the artery tends to be spared from intimal thickening. however, it is not known whethe ... | 1990 | 2341421 |
| morphology of single intracellularly stained axons terminating in area 3b of macaque monkeys. | we have studied the morphology of single thalamocortical axons innervating area 3b of postcentral somatosensory cortex in macaque monkeys. we recorded from axons in the white matter below the representation of the hand in postcentral cortex in two monkeys (macaca fascicularis) by using micropipettes filled with horseradish peroxidase (hrp). when an axon was recorded, we delineated its receptive field and determined its modality, and if cutaneous, whether it was slowly or rapidly adapting (sa or ... | 1990 | 2341626 |
| gustatory responses of single neurons in the insula of the macaque monkey. | 1. in recordings made from 2,925 single neurons, a region of primary taste cortex was localized to the rostral and dorsal part of the insula of the cynomolgus macaque monkey, macaca fascicularis. the area is part of the dysgranular field of the insula and is bordered laterally by the frontal opercular taste cortex. 2. the responses of 65 single neurons with gustatory responses were analyzed in awake macaques with the use of the taste stimuli glucose, nacl, hcl, quinine hcl (qhcl), water, and bla ... | 1990 | 2341869 |
| species, diet, and gender differences in plasma postheparin lipolytic activities in nonhuman primates. relationships with plasma lipids and high density lipoproteins. | studies were done in selected groups of nonhuman primates in which the diet (low fat and high fat as either polyunsaturated or saturated fat), gender, and species (african green monkeys and cynomolgus monkeys) were varied. large differences in plasma lipid and lipoprotein concentrations were found among these groups, providing the opportunity to examine their relationships to postheparin lipolytic activities (phla) including lipoprotein lipase (lpl) and hepatic triglyceride lipase (htgl). phla w ... | 1990 | 2344294 |
| carotid artery atherosclerosis in cholesterol-fed female cynomolgus monkeys. effects of oral contraceptive treatment, social factors, and regional adiposity. | female cynomolgus monkeys, a previously established model of carotid and coronary artery atherosclerosis, were used to study the relationships between potential risk factors and carotid artery atherosclerosis. over a 24-month treatment period, one-third of the monkeys (n = 25) were given the oral contraceptive ovral, one-third of the monkeys (n = 26) were given the oral contraceptive demulen, and the remaining monkeys constituted a control group (n = 26). at necropsy, the atherosclerosis extent ... | 1990 | 2344295 |
| n-modified fluorophenyltropane analogs of cocaine with high affinity for cocaine receptors. | the binding properties of three n-modified fluorophenyltropane analogs of cocaine were compared in competition experiments with [3h]cocaine. all three analogs displaced specifically bound [3h]cocaine from caudate-putamen membranes of cynomolgus monkeys with affinities exceeding that of cocaine. the compound with the highest affinity, 2 beta-carbomethoxy-3 beta-(4-fluorophenyl)-n-allyl-nortropane, (n-allyl-cfnt) was about three times more potent than cocaine. n-allyl-cfnt also had cocaine-like in ... | 1990 | 2345768 |
| thyroxine 5'-deiodinase in brown adipose tissue of the cynomolgus monkey macaca fascicularis. | brown adipose tissue was identified in axillary, interscapular, subscapular, and cervical fat deposits of male and female cynomolgus monkeys (macaca fascicularis) by histological and immunological techniques. histology included staining of mitochondria with a novelli stain and identification of mitochondria-rich multilocular cells. immunological detection involved separation of homogenate proteins by sodium dodecyl sulphate--polyacrylamide gel chromatography, blotting on to nitrocellulose membra ... | 1990 | 2350490 |
| developmental changes in testicular inhibin and androgen-binding protein during sexual maturation in the cynomolgus monkey, macaca fascicularis. | inhibin was measured by ria in testicular extracts and plasma of cynomolgus monkeys during four stages of sexual maturation. immunoactive inhibin levels were compared to those of another sertoli cell secreted protein, androgen-binding protein (abp). abp steroid-binding (bioactive) activity was measured in testes and epididymal segments using the radiolabeled ligand [3h]dihydrotestosterone (dht). testicular immunoreactive inhibin concentrations were maximal in late prepubertal monkeys, 2.5-3.5 yr ... | 1990 | 2351098 |
| pharmacokinetic studies in animals of a new parenteral penem cp-65,207 and its oral prodrug ester. | the pharmacokinetics of penem cp-65,207 diastereomeric mixture were studied following parenteral administration in mice, rats, beagle dogs and cynomolgus monkeys. as is characteristic for most penems, the serum elimination t1/2 of cp-65,207 in rodents was only 13 minutes for mice and 18 minutes for rats. a linear relationship was observed between dose and cmax following subcutaneous injection of drug in mice. the t1/2 in the beagle dog and monkey following intravenous injection was approximately ... | 1990 | 2351614 |
| nascent vldl from liver perfusions of cynomolgus monkeys are preferentially enriched in rrr- compared with srr-alpha-tocopherol: studies using deuterated tocopherols. | the transport and secretion of vitamin e in lipoproteins have been studied in cynomolgus monkeys fed tocopherols labeled with different amounts of deuterium. the animals were fed a single dose of vitamin e containing 60 mumol of each 2r,4'r,8'r-alpha-(5,7-(c2h3)2)tocopheryl acetate (d6-rrr-alpha-tocopheryl acetate; alpha-tocopherol with natural stereochemistry), 2s,4'r,8'r-alpha-5-(c2h3)tocopheryl acetate (d3-srr-alpha-tocopheryl acetate; alpha-tocopherol with unnatural stereochemistry), and 2r, ... | 1990 | 2351873 |
| macaca fascicularis, a nonpermissive host for the human filarial parasite loa loa. | the ability of the filarial nematode loa loa to infect 2 species of primates was studied. the primate species selected were closely related to species known to be susceptible. a mandrill (mandrillus sphinx) and 6 cynomolgus monkeys (macaca fascularis) were infected by subcutaneous injection of third-stage larvae of human l. loa from gabon. the mandrill developed microfilaremia with an estimated prepatent period of 147 days, but microfilariae were not detected in any of the cynomolgus monkeys. th ... | 1990 | 2352067 |
| [dye lasers: experimental histopathologic study of the effects of various wavelengths on the macular region]. | pathological experimental study of dye laser photocoagulation simulating the confluent treatment of subretinal new vessels in the macular area of a macacas cynomolgus monkey. 38 days after treatment the lesions become similar on the choriocapillaris and retinal pigment epithelium whatever the wavelength; the choriocapillaris is always occluded and the pigment epithelium destroyed. the internal limiting membrane is ondulated only with yellow and orange colors. these results are compared to those ... | 1990 | 2357749 |
| neuronal responses related to the novelty and familarity of visual stimuli in the substantia innominata, diagonal band of broca and periventricular region of the primate basal forebrain. | this study examined correlates of memory processes in neuronal activity recorded from the substantia innominata, the diagonal band of broca and the periventricular region or the basal forebrain of monkeys performing recognition and/or visual discrimination tasks. two types of neurons were found that responded differentially to stimuli on the basis of their novelty or their familiarity. neurons (5/572) in the periventricular region rostral to the thalamus and caudal to the anterior commissure res ... | 1990 | 2358021 |
| serum reference values of the cynomolgus monkey, a model for the study of atherosclerosis. | the usual biochemical parameters were evaluated in 19 cynomolgus monkeys (male and female), receiving a normal balanced diet. the values were near those reported in man, although certain differences were observed. | 1990 | 2358793 |
| convergence of heterotopic nociceptive information onto neurons of caudal medullary reticular formation in monkey (macaca fascicularis). | 1. recordings were made in anesthetized monkeys from neurons in the medullary reticular formation (mrf) caudal to the obex. responses of 19 mrf neurons to mechanical, thermal, and/or electrical stimulation were examined. mrf neurons exhibited convergence of nociceptive cutaneous inputs from widespread areas of the body and face. 2. mrf neurons exhibited low levels of background activity. background activity increased after periods of intense cutaneous mechanical or thermal stimulation. nearly al ... | 1990 | 2358866 |
| cynomolgus monkeys. | in the report "tick anticoagulant peptide (tap) is a novel inhibitor of blood coagulation factor xa" by l. waxman et al. (4 may, p. 593), the second sentence of the caption of figure 2 was printed incorrectly. it should have read, "determination of the intrinsic k(i) was done by fitting the observed data (*) with nonlinear regression analysis to the ratio of inhibited velocity (v(i)) to uninhibited velocity (v(o)) described by the equation v(i)/v(o) = [e(t) - i(t) k(*)(i)] + [(i(t) + k(*)(i) - e ... | 1990 | 2360042 |
| mk-927: a topically active ocular hypotensive carbonic anhydrase inhibitor. | mk-927 (dl-5,6-dihydro-4-(2-methylpropylamino)-4h-thieno(2,3b)thiopyra n-2-sulfonamide-7,7-dioxide hydrochloride) is a water soluble, carbonic anhydrase inhibitor (cai) possessing a ki of 12.0 nm against purified human carbonic anhydrase ii in vitro. the acute instillation of one drop (50 microliters) of 0.5%, 1% and 2% solutions of mk-927 maximally decreased the intraocular pressure (iop) of ocular hypertensive, cynomolgus monkeys by 4.7, 5.9 and 9.6 mm hg, respectively. the decline of 9.6 mm h ... | 1990 | 2362161 |
| interhemispheric transfer of visuomotor conditional learning via the anterior corpus callosum of monkeys. | two experiments examined interhemispheric transfer of learning across the anterior corpus callosum in monkeys (macaca fascicularis). the animals learned a series of visuomotor conditional discrimination problems for food reward. within each problem the animals were first trained using one hand to make the motor responses, and were then required to use the opposite hand in order to test for intermanual transfer of the initial learning. in exp. 1, a group of animals with surgical section of the en ... | 1990 | 2363832 |
| the long-term retention of events in monkey memory. | nine monkeys (macaca fascicularis) demonstrated long-term memory for objects in a recognition task based on the non-matching-to-sample (nmts) paradigm. in this task, the subjects were required to choose a novel object when it was paired with an alternative that had become familiar in previous nmts training. when the familiar objects had been experienced an average of 3.4 times 4-9 months previously, 5 monkeys made 79% correct choices of the novel object. three other monkeys exposed to the object ... | 1990 | 2363839 |
| the cutaneous branch of the mylohyoid nerve in the crab-eating monkey (macaca fascicularis). | cutaneous branches of the mylohyoid nerve were observed in both sides of 25 (83.3%) and in one side of 5 (16.7%) out of 30 crab-eating monkeys (macaca fascicularis). the branch supply the skin and sinus hairs at the mental part. these sinus hairs seem to be the intermandibular sinus hairs according to the manner of nerve supply. | 1990 | 2367068 |
| a procedure for removing the blurring in microdensitometric analysis. | the bone width of the femur and fibula was measured by three techniques, osteometry, radiogrametry and microdensitometry, in six adult crab-eating monkeys (macaca fascicularis). the measurement was taken five times at midshaft and at proximal and distal epiphyseal sites in each bone. based on the paired t test, the bone width obtained microdensitometrically was significantly greater than that measured by other techniques (p less than 0.05). it seems to be one of the causative factors for these d ... | 1990 | 2367069 |
| regional cerebral blood flow and distribution of [99mtc]ethyl cysteinate dimer in nonhuman primates. | increases in regional cerebral blood flow have been described in a variety of cerebral pathologic states, including stroke and seizure disorders. the usefulness of technetium-99m-labeled cysteinate dimer as a marker in the measurement of regional cerebral blood flow was tested in five cynomolgus monkeys. to expand the range of blood flow to beyond the normal limits, 40 mg/kg i.v. of the carbonic anhydrase inhibitor acetazolamide was administered. regional cerebral blood flow in all five monkeys ... | 1990 | 2368107 |
| optic nerve head extracellular matrix in primary optic atrophy and experimental glaucoma. | unilateral glaucomatous optic neuropathy and optic nerve transections were produced in cynomolgus monkeys, and the optic nerve heads were examined by light and electron microscopic immunohistochemistry. glaucomatous nerve heads showed increased labeling for collagen type iv along the margins of beams in the lamina cribrosa, due to accumulation of basement membrane-like materials. we also noted material in the pores of the laminar beams that labeled with antibodies to collagen types i, iii and iv ... | 1990 | 2369339 |
| light and electron microscopic morphology of the temporomandibular joint in growing and mature crab-eating monkeys (macaca fascicularis): the condylar articular layer. | in an attempt to establish maturational alterations in the morphology of the articular tissue layer, mandibular condyles of four immature and four mature male monkeys (macaca fascicularis) were studied using light microscopy as well as scanning and transmission electron microscopy. specimens were fixed in situ by perfusion in the presence of ruthenium red to stabilize proteoglycans. preparations intended for observation in the scanning electron microscope were first dehydrated and sputtered for ... | 1990 | 2372135 |
| disappearance of concentrated hyaluronan from the anterior chamber of monkey eyes. | the removal of hyaluronan (hya) from the primate eye has received attention due to the use of the polymer in ophthalmic surgery. the turnover of concentrated hya injected into the anterior chamber of 12 cynomolgus monkeys was therefore studied using a technique earlier described for rabbits. the technique is based on the observation that when hya labelled with tritium in the acetyl group leaves the eye and enters the circulation it is rapidly taken up by the liver and degraded to tritiated water ... | 1990 | 2373182 |
| the effect of prostaglandin f2 alpha on trabecular outflow facility in cynomolgus monkeys. | cynomolgus monkeys were treated topically in one eye with 2 micrograms of prostaglandin f2 alpha -l-isopropylester (pgf2 alpha-ie) twice daily. on day 4, 3 hr after the seventh dose, intraocular pressure (iop) was 8.1 +/- 0.7 mmhg lower in the treated than in the control eyes. on day 5, after the ninth pgf2 alpha dose, gross facility was measured in both eyes by determining the rate of fluid flow from an external reservoir into the eye at two different iop levels. simultaneously, trabecular faci ... | 1990 | 2373185 |
| lipopolysaccharide and tumor necrosis factor cause a fall in plasma concentration of lecithin: cholesterol acyltransferase in cynomolgus monkeys. | the effects of intravenous injection of lipopolysaccharide (lps) and tumor necrosis factor alpha (tnf) were investigated in cynomolgus monkeys (macaca fascicularis). injection of 20 micrograms/kg of lps from e. coli (serotype 055:b5) into cynomolgus monkeys fed a monkey chow diet caused a twofold increase in plasma triglyceride and a 25% reduction in plasma cholesterol 48 h after injection. similar results were found with injection of recombinant human tnf at a dose of 20 micrograms/kg into chow ... | 1990 | 2373960 |
| effects of tamoxifen on corpus luteum function and luteal phase length in cynomolgus monkeys. | previous data in nonhuman primates have demonstrated that tamoxifen prolongs the luteal phase without altering reproductive hormone levels. a small study in humans found no effect on menstrual cycle length, but an increase in luteal ovarian steroid levels. in view of these conflicting results, we studied the effect of tamoxifen on corpus luteum (cl) function in monkeys (n = 20). blood was obtained daily beginning cycle day 8, and sera assayed for estradiol (e2), progesterone (p), luteinizing hor ... | 1990 | 2379633 |
| the effect of beclobric acid and clofibric acid on peroxisomal beta-oxidation and peroxisome proliferation in primary cultures of rat, monkey and human hepatocytes. | the peroxisome-proliferating effects of clofibric acid and beclobric acid were studied in primary cultures of hepatocytes derived from rat, monkey (macaca fascicularis) and human liver. determination of peroxisomal fatty acid beta-oxidation and morphometrical analysis of the peroxisomal compartment were performed after incubation of 1-day-old hepatocyte cultures for 3 days with either compound. in rat liver cell cultures both compounds gave a 10-fold increase in peroxisomal beta-oxidation, a 3-f ... | 1990 | 2383284 |
| changes in erg amplitude following laser induced damage to the primate retina. | the flash evoked erg is used extensively as a measure of retinal function. to understand better the relationship between extent of retinal damage and the erg we created multistage laser lesions in one eye each of three macaca fascicularis monkeys. an argon-dye laser was used to deliver 630 nm energy to cumulative quarter sectors of the temporal hemiretina and the foveal region at two week intervals. latencies of the a- and b-waves and amplitude from the trough of the a-wave to peak of the b-wave ... | 1990 | 2383998 |
| effects on bone of surgical menopause and estrogen therapy with or without progesterone replacement in cynomolgus monkeys. | the influence of estrogen replacement therapy on bone loss of surgically postmenopausal cynomolgus macaques was evaluated histomorphometrically using the first (l-1) lumbar vertebra and ex vivo dual photon absorptiometry of the third (l-3) lumbar vertebra. the animals were a subgroup of a larger study on the effects of estrogen replacement therapy on diet-induced coronary artery atherosclerosis. the three experimental conditions were as follows: untreated females with oophorectomy, females with ... | 1990 | 2386153 |
| effects of various anesthetic and autonomic drugs on refraction in monkeys. | resting refractive correction in ketamine-, pentobarbital-, or halothane-anesthetized rhesus and cynomolgus monkeys was approximately 1-3 diopters myopic, with little difference under the various anesthetic regimens. topical cyclopentolate or atropine, or systemic hexamethonium eliminated much of the myopia, while epinephrine, phenylephrine and thymoxamine had little effect. anesthesia-induced myopia in monkeys thus seems comparable to tonic accommodation ("night myopia") in the human. accommoda ... | 1990 | 2387164 |
| chlamydial heat shock proteins and trachoma. | two chlamydial proteins (hsp-60 and hsp-70) have marked homology with bacterial and mammalian heat shock proteins. previous studies have indicated that when inoculated into the eyes of immune animals, a triton x-100 extract of chlamydia containing hsp-60 induces an ocular delayed-type hypersensitivity reaction. the potential for hsp-70 to induce a similar reaction was tested in six cynomolgus monkeys that had been sensitized to both antigens by previous ocular chlamydial infection. whereas the c ... | 1990 | 2387634 |
| high-density lipoprotein response to 5-alpha-dihydrotestosterone and testosterone in macaca fascicularis: a hormone-responsive primate model for the study of atherosclerosis. | a decrease in high-density lipoprotein cholesterol (hdl-c), a major risk factor for coronary artery disease, occurs during puberty in males. previous studies have shown this decrease with testosterone (t) therapy for adolescent males, but the mechanism of this effect is unknown and has not been studied in a non-human primate. two adult male monkeys (macaca fascicularis) were studied to determine simultaneous changes in plasma androgens and hdl-c during the phases precastration (ci); postcastrati ... | 1990 | 2392061 |
| toxicity of intravesical recombinant human tumor necrosis factor in cynomolgus monkeys. | six groups of two cynomolgus monkeys were treated with escalating intravesicular doses of recombinant human tumor necrosis factor (rhutnf) for a 6 week interval. the doses of rhutnf ranged from 10 ng to 1 mg and were instilled weekly. two monkeys had instillation of saline only and served as controls. the monkeys were weighed and temperatures determined before, immediately after, and 2 days following each treatment. cystoscopic examination was performed 2 days after each treatment and blood samp ... | 1990 | 2395009 |
| behavioral thermoregulation in long-tailed macaques: effect on social preference. | environmental and behavioral data were collected on a captive group of six long-tailed macaques housed in an outdoor cage to determine whether intragroup spacing behavior would vary in a consistent manner in relation to microclimatic variables. records were made of ambient temperature, relative humidity, and time of day. temperature was found to influence proximity between the monkeys. under cool conditions, the long-tailed macaques of this study increased interindividual body contact, a behavio ... | 1990 | 2395916 |
| experimental infection of macaques with hiv-2ben, a novel hiv-2 isolate. | ten rhesus (macaca mulatta) and six fascicularis (macaca fascicularis) macaques were inoculated with hiv-2ben using three different virus preparations and two routes of inoculation. thirteen of the 16 inoculated macaques seroconverted 2-6 weeks after infection. three m. mulatta remained seronegative. the seroconverted animals developed antibody titres from 80 to 40,000. their antibodies reacted with gp160 and gp130 and, in varying degrees, with gp32 and core proteins. virus could be re-isolated ... | 1990 | 2397054 |
| aneurysm formation in experimental atherosclerosis: relationship to plaque evolution. | to determine whether aneurysms form in experimental diet-induced atherosclerosis, we reviewed our experience with cynomolgus monkeys (n = 268) and rhesus monkeys (n = 175) fed an atherogenic diet for various lengths of time. many animals in long-term experiments were fed "regression" diets and cholestyramine to lower cholesterol levels after lesions were established. no aneurysms were found in animals on normal diet. there were no aneurysms in 252 animals fed an atherogenic diet with or without ... | 1990 | 2398583 |
| [the induction of cancer of the large intestine in macaca fascicularis monkeys with 1,2-dimethylhydrazine]. | continuous subcutaneous administration of 16 mg/kg body weight 1,2-dimethylhydrazine three times a month (total dose--1080-3696 mg) to macaca fascicularis monkeys induced cancer invariably confined to the colon within 34-47 weeks. biologic, clinical, histologic features and natural course of the tumor proved similar to those of its human counterpart. | 1990 | 2399668 |
| characterization of oxidized and glucuronidated metabolites of retinol in monkey plasma by thermospray liquid chromatography/mass spectrometry. | eight metabolites of retinol were isolated by high-performance liquid chromatography (hplc) from the plasma of the non-human primate macaca fascicularis after acute exposure to 150,000 iu of vitamin a per kilogram body weight. after enrichment and further chromatographic purification, the metabolites were reinjected individually into a second hplc system which was connected on-line by a thermospray interface to a mass spectrometer operated in the positive ionization mode. six retinoids were iden ... | 1990 | 2400853 |
| ciliary muscle choline acetyltransferase and acetylcholinesterase after ciliary ganglionectomy. | choline acetyltransferase (chat; ec 2.3.1.6) and acetylcholinesterase (ache; ec 3.1.1.7) activities were measured in cynomolgus monkey ciliary muscle 1 month and 6 or more months after ciliary ganglionectomy (cg) or post-ganglionic ciliary neurectomy (pcn). chat activity was undetectable and ache activity was elevated 1 month after cg or pcn, while both averaged about 30% of normal levels 6 or more months after denervation. four out of six eyes reinnervated by functional criteria 6-12 months aft ... | 1990 | 2401348 |
| characterization and distribution of angiotensin-ii receptors in the primate fetus. | the binding characteristics and distribution of angiotensin-ii (aii) receptors were studied in cynomolgus monkey fetuses and one second trimester human fetus. in contrast to the adult monkey, in which binding was confined to the adrenal gland, kidney, and smooth muscle, autoradiographic studies in the monkey fetus revealed the presence of high density binding in mesenchymal tissue throughout the body, especially in skeletal muscle and dermis. in the kidney at 11 weeks, binding was mainly associa ... | 1990 | 2401704 |
| ru 486 (mifepristone): induction of dose dependent elevations of estradiol receptor in endometrium from ovariectomized monkeys. | this study was designed to investigate the effect of the anti-progestin ru 486 on estradiol receptor concentrations in the endometrium of monkeys given physiologic estrogen replacement therapy. estradiol-17 beta (e2) silastic implants were inserted infrascapularly into 12 long-term ovariectomized cynomolgus monkeys (macaca fascicularis) resulting in an average peripheral serum level of approximately 100 pg/ml estradiol. on day 6 of e2 treatment four treatment groups were initiated: group i--estr ... | 1990 | 2401709 |
| the uptake of tritiated diethylstilbestrol by the brain, pituitary gland, and genital tract of the fetal macaque: a combined chromatographic and autoradiographic study. | to examine the possible sites of action of the synthetic estrogen diethylstilbestrol (des) in the developing primate, [3h]des (250 mu ci, iv, or 500 mu ci, sc) was administered directly into two rhesus and nine cynomolgus macaque fetuses at about 122 days gestation (range, 121-124 days). the location of cells accumulating radioactivity 60 min later was examined by autoradiography in two males and two females. in females, labeled neurons were observed in the hypothalamus, preoptic area, and amygd ... | 1990 | 2401716 |
| measurement of circulation time in the retinal vasculature using selective angiography. | retinal circulation times (rct) and mean circulation time (mct) in the retinal vasculature have been used to determine the effect of ocular disease on retinal circulation. both rct and mct are usually determined by measuring dye dilution curves during a traditional fluorescein angiogram. the authors present a variation of the dye dilution technique. the primary difference is that a fluorescent dye (carboxyfluorescein or calcein) was encapsulated in liposomes at a very high concentration. the dye ... | 1990 | 2402418 |
| renal hemodynamics and prostaglandin e2 excretion in a nonhuman primate model of septic shock. | the mechanisms responsible for renal insufficiency in septic shock (ss) have not been well characterized. we therefore investigated renal hemodynamics and the renal excretion of prostaglandin e2 (pge2) in a nonhuman primate model of severe, low systemic vascular resistance (svr) ss. in 18 cynomolgus monkeys, ss was induced by an infusion of 3 x 10(10) live escherichia coli per kg; five saline-treated animals served as nonseptic controls. systemic and renal hemodynamics, and urine pge2 concentrat ... | 1990 | 2403507 |
| decreased immunologic responsiveness following intensified vaginal immunization against urinary tract infection. | in an attempt to further increase the protective effect of vaginal immunization against urinary tract infections in cynomolgus monkeys, the immunogen of killed e. coli was given more times, in larger amounts, and with the adjuvant mdp. instead of increasing the protective effect, no protective effect on induced cystitis was observed. in addition, rises in urinary and serum immunoglobulins previously observed after vaginal immunization and induced cystitis were lessened. these observations appear ... | 1990 | 2403596 |
| experimental infection with chlamydia pneumoniae in nonhuman primates. | to serially examine the immunopathogenesis and histopathology of infection with chlamydia pneumoniae, we inoculated two cynomolgus monkeys in the conjunctival sac, nose, and nasopharynx with c. pneumoniae twar. after inoculation, c. pneumoniae was isolated from the inoculation sites and the rectums of both monkeys for a period of 5 weeks. after a second inoculation, c. pneumoniae was recovered from the inoculation sites and the rectums of both monkeys for 20 weeks. a third inoculation with c. pn ... | 1990 | 2407650 |
| uveoscleral outflow following cyclodialysis in the monkey eye using a fluorescent tracer. | cyclodialysis was performed in one eye of each of eight cynomolgus monkeys. two days later, the intraocular pressure was 1.6 +/- 0.7 mmhg in eyes with cyclodialysis and 12.0 +/- 0.7 mmhg in fellow control eyes. 10(-4) m fluorescein-isothiocyanate dextran (70,000 molecular weight) was perfused into the anterior chamber of each eye for 30 min. the eyes were enucleated and dissected into sclera, choroid, retina, iris, and ocular fluid. samples were homogenized and centrifuged, and the fluorescence ... | 1985 | 2409046 |
| influence of cell cycle phase-specific agents on simian fetal hemoglobin synthesis. | to determine the influence of cell cycle-specific agents on primate hematopoiesis and fetal hemoglobin production, two juvenile cynomolgus monkeys (macaca fascicularis) were repeatedly bled to maintain their hemoglobins at approximately 6.5 g/dl and fetal hemoglobin levels at 3-5%. six separate 5-d courses of hydroxyurea at 100 mg/kg per d were then administered over the next 200 d while phlebotomy was continued. these courses of hydroxyurea progressively raised the fetal hemoglobin levels to 17 ... | 1985 | 2409112 |
| carbonic anhydrase in epithelia and fenestrated juxtaepithelial capillaries of macaca fascicularis. | thirty-nine epithelia of the monkey macaca fascicularis and their underlying connective tissue were stained for carbonic anhydrase (ca) and studied by light microscopy. the capillaries immediately adjacent to the epithelium, 'juxtaepithelial', were also studied by electron microscopy with special attention to presence or absence of fenestrations. only juxtaepithelial capillaries stained. these were fenestrated under many epithelia and all fenestrated juxtaepithelial capillaries stained. often st ... | 1985 | 2409749 |
| cynomolgus monkeys and morphine tolerance and dependence. | cynomolgus monkeys readily developed tolerance to and physical dependence on morphine indistinguishable from that produced by an identical dose regimen in rhesus monkeys. | 1985 | 2410213 |
| connections of the fronto-parietal operculum and the postcentral gyrus with the posterior ventral thalamic nucleus, especially its medial nucleus, in monkeys. | in 22 crab-eating monkeys (macaca irus), either lesions or hrp injections were made in the frontol parietal operculum and, for the purpose of contrast, in the postcentral gyrus to observe their fiber connectionl with the posterior ventral nucleus (vp). the exposed opercular part, reported to consist of areas 3b, 1, and 2 showed scanty fiber connections with vp. the buried parietal operculum had connections with the media (vpm) and lateral (vpl) nuclei of vp, corresponding to the second somatic s ... | 1985 | 2411787 |
| development of antigen-specific cell-mediated immune responses after infection of cynomolgus monkeys (macaca fascicularis) with rickettsia tsutsugamushi. | cynomolgus monkeys were evaluated for cellular immune responses after infection with the karp strain of rickettsia tsutsugamushi. antibody and clinical signs of localized and systemic infection were also evaluated. animals challenged with homologous or heterologous strains at various times after a primary infection were also followed up. naive monkeys developed eschars, lymphadenopathy, rickettsemia, and elevated body temperatures. antibody in these animals was igm followed by igg. lymphocyte pr ... | 1985 | 2413138 |
| contractile effects of vanadate on monkey and rabbit tracheal smooth muscle. | the effects of vanadate (na3vo4: van) on isolated tracheal smooth muscle of monkey (macaca fascicularis) and rabbit were examined. van (10(-5)-10(-3) m) induced a sustained contraction in both tracheae which was not affected by atropine, tetrodotoxin or tripelennamine. indomethacin potentiated van-induced contraction in monkey trachea but had no effect in rabbit trachea. in ca-free solution, high k was ineffective whereas van or carbachol induced a small transient contraction. in both tracheae, ... | 1985 | 2413812 |
| blockage at two points of axonal transport in glaucomatous eyes. | blockage of axonal protein transport in intraocular hypertensive primates (macaca irus) was studied autoradiographically and quantitatively and the findings compared with our previous work on rabbits. fast axonal transport was blocked at two points, at the lamina scleralis and at the edge of posterior scleral foramen, and reduced by 25% when intraocular pressure of 50 mmhg continued for 6 h. the importance of the blockage at the lamina scleralis and at the edge of scleral foramen for the explana ... | 1985 | 2414159 |
| a specific iron stain for iron-binding proteins in polyacrylamide gels: application to transferrin and lactoferrin. | a new method for specifically staining the iron atoms present in transferrin and lactoferrin after polyacrylamide gel electrophoresis and isoelectric focusing is described. the stain, 3-(2-pyridyl)-5,6-bis(2-(5-furylsulfonic acid))-1,2,4-triazine, disodium salt, or ferene s, will detect transferrin in 5 microliters of human serum, lactoferrin in 10 microliters of human whey, and 10 micrograms of purified primate (macaca fascicularis) transferrin. this method of staining is very rapid as the seru ... | 1985 | 2415022 |
| sequelae of intravitreal phagocytic activity in response to microparticles. | cynomolgus monkeys were injected intravitreally with a colloidal suspension of carbon microparticles (size 20-70 nm) under aseptic surgical conditions. an intravitreal cellular proliferation occurred, inducing retinal detachment and neovascularization that started from the optic nerve head, ciliary body and ora serrata. transmission electron microscopy revealed the features of the intravitreal cellular response to be inflammatory cells, mononuclear phagocytes (the predominant cell type), and fib ... | 1985 | 2417444 |
| experimental intravitreal proliferation and neovascularization in the cynomolgus monkey. | an experimental model for intravitreal cellular proliferation was produced by injection of carbon microparticles into the vitreous of nine cynomolgus monkeys. eighteen eyes were studied following enucleations 10 weeks after the injections. histological examinations showed retinal folds or detachments in 16 eyes, while 6 of those had total detachments. eight eyes contained transvitreal fibrovascular strands, passing from the optic disk to a "cyclitic" retrolental membrane. the strands and membran ... | 1986 | 2417915 |
| the primate serotonergic system: a review of human and animal studies and a report on macaca fascicularis. | this chapter has reviewed biochemical and morphological studies of the human and monkey serotonergic system. in addition, the serotonin-producing neurons of m fascicularis were analyzed, using immunocytochemistry, radioautography, and measurements of synaptosomal serotonin reuptake and supernatant tryptophan hydroxylase activity. the major sections of the chapter covered cell bodies, pathways, subcortical distribution, and cortical distribution, and a gross brain dissection guide of m fascicular ... | 1986 | 2418648 |
| p300-like potentials in the normal monkey using classical conditioning and an auditory 'oddball' paradigm. | endogenous components of evoked potentials resembling p300 in humans were sequentially studied in 3 cynomolgus monkeys (macaca fascicularis) using an auditory 'oddball' paradigm. the two different auditory stimuli were 500 hz and 4000 hz tones, designated as the 'frequent' and 'rare' stimuli, respectively. the probability of 'rare' tone presentation was initially 0.2. we further used probabilities of 0.1, 0.3 and 0.5. the 'rare' stimulus was reinforced by electrical stimulation, which followed t ... | 1986 | 2420576 |
| [effect of hypothyroidism on mitochondrial energy metabolism and nuclear synthesis of rna in the liver of cynomolgus monkeys]. | the effects of hypothyroidism and of replacement therapy with t4 or t3 were studied on the enzymatic activities of liver subcellular fractions isolated from cynomolgus monkeys. animals were sacrificed 20 days after thyroidectomy. in mitochondria, thyroidectomy decreased significantly the respiratory chain activity (succinate cytochrome c-reductase), the transfer of cytosolic reducing equivalents (glycerol-3-phosphate dehydrogenase) and the phosphorylating capacity (oligomycin-sensitive atpase an ... | 1985 | 2423208 |
| primate model of neovascular glaucoma. | iris neovascularization has been reproducibly created in cynomolgus monkey eyes by argon laser occlusion of retinal veins. pre-treatment of the eyes with lensectomy and vitrectomy (before the retinal vein occlusion) led to a more rampant development of the iris neovascularization in all eyes, as well as development of neovascular angle closure glaucoma in two of the 12 eyes. histopathologic examination confirmed the finding of neovascular angle closure. this primate model may allow further inves ... | 1986 | 2424854 |
| long-term effects of mptp on central and peripheral catecholamine and indoleamine concentrations in monkeys. | 5 macaca fascicularis monkeys developed a severe parkinsonian syndrome in the days following intravenous administration of the toxin mptp. one monkey remained untreated while two groups of two animals were treated daily for 5 months with supramaximal oral doses of either sinemet or bromocriptine. both drugs relieved the parkinsonian symptoms. plasma prolactin concentrations were elevated in mptp-treated monkeys compared to intact monkeys. mptp caused a rapid decrease of homovanillic acid (hva) c ... | 1986 | 2427166 |
| hypotony and experimental rubeosis iridis in primate eyes. a clinicopathologic study. | rubeosis iridis was produced in cynomolgus monkeys by subjecting their eyes to severe surgically induced hypotony. new vessels on the iris showed characteristic fenestrations of endothelial cell walls as well as mitotic activity. | 1986 | 2428697 |
| immunostaining of a cell type in the islets of langerhans of the monkey macaca irus by antibodies against s-100 protein. | s-100 protein-immunoreactive cells were demonstrated by immunocytochemical procedures in the pancreatic islets of langerhans in the monkey macaca irus. by use of antibodies against human s-100 protein or bovine s-100 protein, these cells were observed in all islets in the head and tail portions of the pancreas. immunostained cells were usually located in the center of the islets or sometimes found in a more widely distributed form, but they were never arranged in a regular concentric fashion. th ... | 1987 | 2435409 |
| [effect of thyroidectomy on phosphorylative oxidation and rna synthesis in various regions of the brain in the adult monkey]. | the subcellular effects of thyroidectomy in selected brain regions of cynomolgus monkey were analyzed. 20 days after operation the respiratory rates, the activities of succinate cytochrome c reductase, glycerol-3-phosphate dehydrogenase and of oligomycin-sensitive atpase were decreased in mitochondria isolated from all brain structures. the highest reduction (30%) was found in cerebral cortex and hippocampus. cerebellar and striatal activities were reduced by about 20%. a smaller decrease (15%) ... | 1986 | 2436727 |