Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| synthesis, antimalarial activity, and quantitative structure-activity relationships of tebuquine and a series of related 5-[(7-chloro-4-quinolinyl)amino]-3-[(alkylamino)methyl] [1,1'-biphenyl]-2-ols and n omega-oxides. | a series of 5-[(7-chloro-4-quinolinyl)amino]-3-[(alkylamino)methyl] [1,1'-biphenyl]-2-ols and n omega-oxides was prepared from the substituted 1-phenyl-2-propanones proceeding through the 5-nitro[1,1'-biphenyl]-2-ols, the corresponding amino, and acetamido derivatives to the n-[5-[(alkylamino)methyl]-6-hydroxy[1,1'-biphenyl]-3-yl]acetamides and final condensation with 4,7-dichloroquinoline or the n-oxide. in a quantitative structure-activity relationship study first run on 28 and later expanded ... | 1986 | 3712383 |
| murine malaria decreases hemopoietic stem cells. | the causes of anemia and immunosuppression, major outcomes of malaria, are not well established. this study was undertaken to investigate whether erythropoietin (ep) production is adequate and whether the hemopoietic stem cells (cfu-s) were affected during the course of infection. groups of female balb/c mice infected with plasmodium vinckei vinckei, plasmodium berghei, or plasmodium chabaudi adami were exposed to five hours of simulated altitude equivalent to 22,000 ft. plasma samples were coll ... | 1987 | 3801660 |
| the effect of malaria infection on primaquine elimination in the isolated perfused rat liver. | most antimalarial drugs are eliminated by hepatic metabolism. however, the influence of malaria infection on the hepatic elimination of these drugs has not been examined. in the present study the elimination of the antimalarial primaquine has been examined in isolated perfused rat livers (iprl) of malaria-infected sprague-dawley rats (90-110 g) (mi group; n = 6) and age- and weight-matched healthy rats (control group; n = 7). iprl preparations for the mi group were established 12-15 days after r ... | 1987 | 3814168 |
| plasmodium berghei: ectopic antibody synthesis in splenectomized rodents. | jirds (meriones unguiculatus) were able to maintain acquired antimalaria immunity independent of the spleen approximately 4 months after initial infection. the memory cells appeared to become peripheralized, and persist outside the spleen for +/- 10 months if no further antigenic stimulus is applied. with regular stimulation, immunity was maintained indefinitely. in immune splenectomized jirds, the secondary, splenic germinal center function appeared to be taken over by cellular infiltrates in t ... | 1985 | 3881267 |
| folate antagonists. 21. synthesis and antimalarial properties of 2,4-diamino-6-(benzylamino)pyrido[3,2-d]pyrimidines. | the synthesis and antimalarial activity of a series of 2,4,6-triaminopyrido[3,2-d]pyrimidines (4) is described. several 6-substituted benzylmethylamino analogues were more active against trophozoite induced plasmodium berghei in mice than the corresponding quinazoline analogues. these agents, however, are cross-resistant to other antifolate compounds and are thus of limited potential as human agents. | 1985 | 3881585 |
| survival of plasmodium berghei in dead hosts. | 1985 | 3884763 | |
| a double screening trial for the development of drugs against theileria sergenti in cattle using babesia rodhaini and plasmodium berghei in mice. | 1985 | 3884864 | |
| [comparative ultrastructural study of the process of hemoglobin degradation by p. berghei (vincke and lips, 1948) as a function of the state of maturity of the host cell]. | by serial sectioning and 3d reconstruction we have been able to demonstrate that the type of system for hemoglobin digestion in two strains of plasmodium berghei, n and rc, is dependent on the maturity of the host cell. in parasites growing in erythrocytes, both systems for the endocytosis of hemoglobin-micropinocytosis and the cytostomal system (i.e. a cytostome budding a cytostomal tube that releases food vacuoles)-are fully functional and produce a great quantity of residual pigment. parasite ... | 1985 | 3886896 |
| gametocytogenesis and ribosomal rrna gene organisation in the rodent malarias plasmodium chabaudi and plasmodium berghei. | a cloned plasmodium berghei (anka) isolate was syringe passaged repeatedly to generate a line that was non-infective to anopheles stephensi. ribosomal gene organisation of this non-infective line was then compared to its infective ancestor. dna was also prepared from asexual parasites and gametocytes of p. chabaudi and the arrangement of the rrna genes of this species was studied. although macrogametocytes have many more ribosomes than microgametocytes, this increase does not appear to stem from ... | 1985 | 3887155 |
| primaquine and lysosomotropic amines inhibit malaria sporozoite entry into human liver cells. | the binding and entry of plasmodium berghei sporozoites to human hepatoma hepg2 cells is inhibited in a dose-dependent manner by primaquine, chloroquine and other lysosomotropic amines. the site of action of these agents appears to be the hepatoma cell itself, not the sporozoite. while this inhibitory effect of primaquine is rapidly reversible, the precise mechanism responsible for this effect is not presently known. | 1985 | 3887157 |
| qinghaosu (artemisinin): an antimalarial drug from china. | the herb artemisia annua has been used for many centuries in chinese traditional medicine as a treatment for fever and malaria. in 1971, chinese chemists isolated from the leafy portions of the plant the substance responsible for its reputed medicinal action. this compound, called qinghaosu (qhs, artemisinin), is a sesquiterpene lactone that bears a peroxide grouping and, unlike most other antimalarials, lacks a nitrogen-containing heterocyclic ring system. the compound has been used successfull ... | 1985 | 3887571 |
| plasmodium berghei: gluconeogenesis in the infected mouse liver studied by 13c nuclear magnetic resonance. | using 13c nuclear magnetic resonance, we have compared the gluconeogenic activity of perfused livers isolated from normal starved mice and mice highly parasitized with plasmodium berghei, using [2-13c]pyruvate as substrate. in both types of livers, 13c labeling of glucose carbons occurred in positions 1, 2, 5, and 6. the equal proportions of [1,6-13c]- and [2,5-13c]glucose in livers from malarial and normal mice suggests that pyruvate enters the gluconeogenic pathway directly and, to an equal ex ... | 1985 | 3888649 |
| in vitro infectivity of cryopreserved plasmodium berghei sporozoites to cultured cells. | plasmodium berghei sporozoites frozen in mem (eagle) medium supplemented with 10% hydroxyethyl starch and 50% normal mouse serum retained 0.5% infectivity to cultured hepatoma cells, compared to 6.8% before freezing. this demonstrates that frozen-thawed sporozoites can be used in in vitro investigations of the exoerythrocytic malarial parasite and means that when large numbers of sporozoites are available, they may be frozen and preserved for later use. | 1985 | 3890283 |
| qinghaosu-induced changes in the morphology of plasmodium inui. | the ultrastructural changes induced by the administration of the antimalarial drug, qinghaosu, were studied in monkeys (macaca assamensis) infected with plasmodium inui. significant changes, notably mitochondrial swelling within the parasites but not within host cells, were first observed 2.5 hr after exposure to qinghaosu. this suggests that the target of qinghaosu may be the parasite's mitochondria, as occurs with primaquine. this is in contrast to the most widely used antimalarial drug, chlor ... | 1985 | 3890573 |
| malaria immunization--a zimbabwean perspective. | a great deal of activity is being focused on the possibility of developing an effective vaccine for malaria. drug resistance is the main problem. of the new drugs under examination, only meflaquine, a quinine analogue, is at the stage of a clinical trial and even here it appears that resistance may be a problem. this review summarizes the current state of research on malaria immunization and adds some zimbabwean perspectives. natural immunity to malaria is directed against the blood stages o ... | 1985 | 3891094 |
| comparative studies on thymidylate synthetase from p. berghei and mouse reticulocytes. | partially purified thymidylate synthetase from plasmodium berghei and mouse reticulocytes was characterized. the mol. wt of the enzyme from p. berghei was about twice that from mouse reticulocytes. the optimum ph of the enzyme from p. berghei was found to be 6.5-7.5 while that from the host was 7.0-8.0. the enzyme from p. berghei was more susceptible to ph denaturation than the enzyme from reticulocytes. the enzyme from both sources differed in their km values for substrates. the enzyme from ret ... | 1985 | 3891213 |
| use of a monoclonal, anti plasmodium berghei antibody, cross reacting with p. falciparum, for the detection of p. falciparum in in vitro infected blood. | this report describes an immunoradiometric assay for plasmodium falciparum in infected blood, based on a cross-reacting monoclonal antibody (mab) raised against p. berghei. in this assay, binding of the mab to intact p. berghei parasites coated on microtiter plates is inhibited by solubilized p. falciparum infected red blood cells. the use of p. berghei parasites in conjunction with monoclonal antibodies should facilitate the development of an inexpensive and reproducible test for the immunodiag ... | 1985 | 3891600 |
| a possible role for natural killer cells in providing protection against plasmodium berghei in early stages of infection. | beige mutant mice, which are deficient in natural killer (nk) cells, exhibited a significantly higher parasitaemia than the parental c57bl/6 strain between days 4 and 10 after infection with plasmodium berghei. within 8-12 days after infection 70% of beige mice were dead but no deaths occurred in the parental strain until day 16. the median survival time of the beige mice (10 days) was significantly lower than that of the parental strain (22 days). it appears that nk cells may be protective in t ... | 1985 | 3891603 |
| plasmodium berghei: the influence of blood volume changes on the malaria-induced anemia in balb/c mice. | malaria-induced anemia exceeds that attributable to direct parasite destruction of erythrocytes. since spleen and liver weights increase significantly, hemodilution may account for part of this excessive anemia. to determine the role of hemodilution in the etiology of anemia, vascular volumes were measured with evans blue and isotope dilution techniques. the evans blue dilution technique showed that blood volume increased 20%, in infected balb/c mice. however, when blood volume was measured with ... | 1985 | 3892956 |
| nimbolide, a constituent of azadirachta indica, inhibits plasmodium falciparum in culture. | the terpenoid lactone nimbolide, the structure of which has been unambiguously established, was found to inhibit plasmodium falciparum in culture with a moderate potency. the ec50 against the parasite line k1 from thailand was approximately 2.0 microm (0.95 microgram/ml). the ec50 of crude aqueous extract of azadirachta indica var. siamensis (sadao tree), was 115 micrograms/ml, and of crude ethanol extract was 5.0 micrograms/ml. since nimbolide is a major constituent in these extracts, it could ... | 1985 | 3895455 |
| electron microscopic studies on the interaction of rat kupffer cells and plasmodium berghei sporozoites. | the interactions between plasmodium berghei sporozoites and kupffer cells in rat liver were studied by transmission electron microscopy. between 10 and 45 min after inoculation, sporozoites were found in the process of entering kupffer cells and inside phagolysosomes. the sporozoites entered the kupffer cells by phagocytosis as determined by the presence of pseudopods and local accumulations of aggregated microfilaments and the resulting exclusion of other organelles in the phagocyte cytoplasm b ... | 1985 | 3895767 |
| free intraglomerular malarial antigens. | infection with plasmodium berghei leads to a rapidly lethal disease in different strains of mice. nude athymic mice are not able to produce circulating antibodies (igg or igm) against plasmodial antigens. nevertheless, plasmodium-related antigens can be detected in the glomeruli of nude mice, in relation to the rising parasitaemia. this deposition is unrelated to the deposition of other immunoreactants (igg, igm or c3). the presence of the latter as well as the circulating auto-antibodies did no ... | 1985 | 3896290 |
| transformation of sporozoites of plasmodium berghei into exoerythrocytic forms in the liver of its mammalian host. | intrahepatocytic transformation in vivo of the rodent malaria sporozoite of plasmodium berghei, into the young trophic exoerythrocytic tissue stage was studied by immunofluorescence, light- and electron microscopy. the first 20 h of intracellular life were involved entirely in dedifferentiation with limited proliferation of organelles. from about 20 h onwards nuclear division commenced, rough endoplasmic reticulum became markedly expanded, and mitochondria increased in numbers. however, remains ... | 1985 | 3896506 |
| effect of a specific iron chelator, desferrioxamine on the host biochemistry and parasitaemia in mice infected with plasmodium berghei. | 1985 | 3896872 | |
| detection of plasmodium falciparum using a radioimmunoassay based on a crossreacting, monoclonal anti-p. berghei antibody-p. berghei antigen system. | an antibody binding-inhibition test is described, which allows the detection of p. falciparum in red blood cells (rbc) infected in vitro, using a crossreacting, monoclonal anti-p. berghei antibody and p. berghei coated microtiter plates. experiments carried out to determine the coating efficiency of various p. berghei and p. falciparum derived antigen preparations showed that intact, saponin freed p. berghei parasites and sonicated, rbc parasitized with p. falciparum had the highest binding acti ... | 1985 | 3897380 |
| perinatal immune priming in malaria: antigen-induced blastogenesis and adoptive transfer of resistance by splenocytes from rats born of plasmodium berghei infected females. | 1985 | 3897956 | |
| pregnancy-induced recrudescences strengthen malarial immunity in mice infected with plasmodium berghei. | a considerable proportion of mice lose acquired immunity to plasmodium berghei during the first pregnancy. immune parous mice, however, have a better immune status than virgin mice, the risk of loss of immunity during a subsequent pregnancy is greatly reduced, the capacity to clear parasites is enhanced, and the maintenance of immunity is less dependent on certain splenic functions. the establishment of improved immunity is dependent on the presence of proliferating parasites during the second h ... | 1985 | 3897957 |
| [studies on analogs of qinghaosu (artean-nuin, artemisinine). iii. the synthesis of diacid esters and mono esters of dihydroqinghaosu]. | 1985 | 3898722 | |
| a study of the uptake of chloroquine in malaria-infected erythrocytes. high and low affinity uptake and the influence of glucose and its analogues. | a study of concentration- and substrate-dependence of chloroquine uptake has been carried out on mouse erythrocytes infected with the chloroquine-sensitive nk65 and the chloroquine-resistant rc strains of plasmodium berghei. the presence of drug binding sites of high and low affinity in such strains of p. berghei was confirmed. high affinity uptake sites in cells parasitized with chloroquine-sensitive and chloroquine-resistant parasites have similar characteristics, but in the sensitive strain t ... | 1985 | 3899119 |
| acute malaria prolongs susceptibility of mice to plasmodium berghei sporozoite infection. | the fate of immune response against sporozoite stage in malaria infection was investigated. two groups (a and b) of mice were inoculated twice with infective sporozoites of plasmodium berghei. the mice in group a were maintained on chloroquine prophylaxis to prevent the sporozoite infection from causing malaria. group b animals on the other hand were allowed to develop acute malaria from the infection which was subsequently cured with chloroquine. upon examination for stage specific immune respo ... | 1985 | 3899429 |
| malarial parasites complete sporogony in axenic mosquitoes. | to obtain sporogonic stages of malaria free from microbial contaminants for in vitro studies, anopheles stephensi were reared under sterile conditions using a mosquito cell line as larval food. the adult females, kept in sterile humidified containers and allowed to engorge on parasitemic hamsters, supported the sporogonic development of the rodent malarial parasite plasmodium berghei. in 10 experiments, the proportion of infected mosquitoes varied from 0 to 92%, and the geometric mean number of ... | 1985 | 3899715 |
| serum il-2 inhibitor in mice. i. increase during infection. | serum from normal mice contains an inhibitor of interleukin-2 (il-2) which probably interacts directly with il-2. athymic mice and normal mice kept under specific pathogen-free conditions do not show this activity, whereas mice infected with malaria parasites have increased serum levels of inhibitor. this il-2 inhibitor may play an important part in regulating t-cell function. | 1985 | 3899918 |
| the action of salinomycin-na and lasalocid-na on chloroquine- and mepacrine-resistant line of plasmodium berghei k 173-strain in wistar rats. | salinomycin-na and lasalocid-na, two ionophorous antibiotics known for their anticoccidial activity, exhibit in vivo blood schizontocidal action on the plasmodium berghei keyberg 173 rc/m line that has a high level of resistance to chloroquine and mepacrine. salinomycin was found to have a greater effect than lasalocid on asexual stages of this line. trophozoites and schizonts were no longer found after a single dose of 20 mg/kg or five doses of 1.25 mg/kg of salinomycin whereas a single dose of ... | 1985 | 3901567 |
| changes in hematopoietic stem cells in bone marrow of mice with plasmodium berghei malaria. | an impaired erythropoietic response to anemia has been noted in human patients with malaria and in rodents experimentally infected with plasmodium berghei. we have attempted to characterize the erythropoietic response in mice with a fatal p berghei infection, with particular emphasis on changes in marrow hematopoietic stem cells. mice infected with p berghei had dramatic decreases in bone marrow cellularity, erythroblasts, bfu-e, and cfu-e as early as 24 hours postinfection and before there was ... | 1985 | 3902119 |
| evidence against the red blood cell origin of mitogenic factors in mouse malarial infection. | the mean [3h]thymidine incorporation in response to stimulation of spleen cells of malaria-immune and non-immune balb/c mice by normal mouse red blood cell culture supernatants were compared with unstimulated cultures of the same spleen cells. no significant difference was obtained between stimulated and unstimulated cultures for both immune and non-immune spleen cells. these findings do not support the hypothesis that erythrocyte-derived mitogenic factors occur in malarial infection. | 1985 | 3902628 |
| [usefulness of the p. berghei antigen compared with those of p. vivax and p. malariae in evaluating the immune response in human malaria]. | 1985 | 3903951 | |
| effect of plasmodium berghei infection on benzoic acid metabolism in mice. | the metabolism of benzoic acid was studied in plasmodium berghei infected mice both in vitro and in vivo. results of in vitro studies showed a considerable decrease in the ability of the infected liver to detoxify benzoic acid by hippuric acid formation. the in vivo study showed that hippuric acid formation decreases with increasing parasitemia and the emergence of benzoyl-glucuronide. this new pathway stops operating with further increase in parasitemia. | 1985 | 3905430 |
| fine structure of exoerythrocytic merozoite formation of plasmodium berghei in rat liver. | the fine structure of exoerythrocytic merogony of plasmodium berghei was studied after perfusion-fixation of rat livers from 51 h post-inoculation onwards. meroblast formation was effected by clefts originating from the parasite plasmalemma and by fusion of vacuoles with each other. invaginations at the periphery resulted in labyrinthine structures providing the parasites with an enormous increase in surface area, which might facilitate exchange of metabolites. when the parasitophorous vacuole m ... | 1985 | 3906102 |
| identification of the meiotic division of malarial parasites. | zygotes of plasmodium berghei were cultured 15-25 h in vitro to yield mature infective ookinetes. samples taken in the first 5 h of culture were examined by electron microscopy. meiotic figures were detected in the nuclei of the zygotes. threadlike leptotene chromatids (chromosomes) condensed from attachment plaques on the nuclear envelope; chromatid pairing followed (zygotene), with synaptonemal complexes subsequently appearing (pachytene). these complexes persisted into metaphase but dissociat ... | 1985 | 3906103 |
| antimalarial agents. 1. alpha-santonin-derived cyclic peroxide as potential antimalarial agent. | an alpha-santonin-derived cyclic peroxide (7) related to qinghaosu (1) has been synthesized and tested for antimalarial activity in vitro against the chloroquine-resistant (smith) isolates of plasmodium falciparum as well as in vivo against plasmodium berghei in mice and was found to be devoid of activity. | 1985 | 3906128 |
| cytosolic protein kinase activity associated with the maturation of the malaria parasite plasmodium berghei. | seven cytosolic phosphoproteins with relative molecular masses of 110, 58, 52, 46, 38, 36 and 34kda and isoelectric points between 4.2 and 5.0 are identified from the rodent malaria parasite plasmodium berghei. similar patterns of phosphorylated proteins are obtained from parasite cytosol after incubation of intact infected erythrocytes with [32p]orthophosphate, or from parasite cytosol incubated with [gamma-32p]atp. the characteristics of the phosphorylation reaction are similar to the previous ... | 1985 | 3906392 |
| development of plasmodium berghei ookinetes in the midgut of anopheles atroparvus mosquitoes and in vitro. | plasmodium berghei ookinete formation in vitro and within the midgut of susceptible anopheles atroparvus were compared. no significant morphological differences were seen, except that in vitro development was more synchronized and less degenerating forms occurred. in vitro ookinete yields were 4-31 times higher and less variable than those in vivo. mosquitoes of a susceptible and of a refractory line of a. atroparvus were simultaneously fed on the same host or via a membrane with the same suspen ... | 1985 | 3906518 |
| the development of plasmodium ookinetes in vitro: an ultrastructural study including a description of meiotic division. | ookinetes have been cultured in vitro using modifications to the method of weiss & vanderberg (1977). significant improvements in technique were produced by culture in medium at ph 8.4 and at a blood dilution at or over 1/10. ookinetes produced were infective to mosquitoes by membrane feeding techniques. ultrastructural analyses were made of nuclear, cytoskeletal, crystalloid and microneme development. the first intranuclear division in the zygote has been recognized as meiosis. chromosome conde ... | 1985 | 3906519 |
| immunity to an attenuated variant of plasmodium berghei: role of some non-specific factors. | plasmodium berghei xat, an attenuated variant of lethal p. berghei, causes a resolving infection in balb/c mice from which they recover in about 3 weeks. the parasitaemia displays an early peak at about 5 days, followed by a steep drop in parasite number associated with the appearance of degenerating forms inside mature erythrocytes; the parasites remaining are inside reticulocytes. by contrast, no degenerating parasites were seen in infections caused by the virulent parent, which was mainly con ... | 1985 | 3906521 |
| synthesis of quinoline-mannich bases of possible antimalarial activity. | for possible antimalarial activity, a series of some 4-substituted aminoquinoline mannich bases (5a-e) was synthesized. the antimalarial evaluation showed that compound 5b was active against plasmodium berghei in mice at a dose of 100 mg/kg. | 1985 | 3906678 |
| [the effects of artemether on serum igg and spleen weight in mice]. | 1985 | 3907273 | |
| studies on the loss of sexual capacity in the anka isolate of plasmodium berghei and the reversibility of the process. | 1985 | 3907527 | |
| the delivery of exoerythrocytic parasites of plasmodium berghei: a hormone controlled process. | 1985 | 3907538 | |
| [criteria and circumstances of viability of gametocytes of plasmodium berghei]. | 1985 | 3907543 | |
| chloroquine induces oxidative lysis of plasmodium berghei parasitized red blood cells. | 1985 | 3907546 | |
| the chemotherapy of rodent malaria, xxxix. ultrastructural changes following treatment with artemisinine of plasmodium berghei infection in mice, with observations of the localization of [3h]-dihydroartemisinine in p. falciparum in vitro. | ultrastructural changes were followed in plasmodium berghei after the treatment of the mouse host with a single 10 mg kg-1 dose of artemisinine (qinghaosu). after 30 minutes, changes in the limiting and other membranes of the parasite were seen, together with alterations in ribosomal organization and endoplasmic reticulum. no changes were noted in digestive vacuoles or pigment, but nuclear membrane blebbing developed after one hour and segregation of the nucleoplasm after three hours. further de ... | 1985 | 3907556 |
| plasmodium berghei: oxidant defense system. | glutathione oxidant defense system protects the erythrocyte from oxidative damage. this defense system was studied in mouse erythrocytes infected with plasmodium berghei and in isolated parasites. the efficiency of this system was found to be increased in parasitized erythrocytes compared to the normal erythrocytes. the increase in the components of the oxidant defense system in the parasitized cells could result from parasitic addition to these components. this defense system present in the par ... | 1985 | 3908136 |
| guanosine triphosphate cyclohydrolase in plasmodium falciparum and other plasmodium species. | gtp cyclohydrolase (ec 3.5.4.16), the first enzyme in the pteridine pathway leading to the de novo formation of folic acid, has been identified and isolated from the human malaria parasite, plasmodium falciparum. the enzyme was purified 200-fold by high performance size-exclusion chromatography on a tsk-g-3000 sw protein column. the molecular weight was estimated at 300 000. optimal enzyme activity was observed at ph 8.0 and 42 degrees c. the km for gtp was 54.6 microm. products of the enzyme re ... | 1985 | 3908934 |
| synchronized erythrocytic schizogony and gametocytogenesis of plasmodium berghei in vivo and in vitro. | both asexual and sexual development of plasmodium berghei was synchronized without chemical intervention using in vitro culture techniques. combined in vivo and in vitro experiments were performed on the relationship between age, morphology and maturity of gametocytes. schizogony took 22-23 h in the experiments. at 26 h post-invasion (p.i.) the first males became capable of exflagellation. by 20 h p.i. the first gametocytes were recognizable in giemsa-stained smears but the sex was hardly distin ... | 1985 | 3909068 |
| [changes in the white blood indices in experimental malaria in mice]. | 1985 | 3911038 | |
| [microsomal monooxygenase inhibitors as promising agents for overcoming the drug resistance of the malaria parasite]. | a relationship was found between resistance of malarial plasmodium to chloroquine and the increased activity of microsomal monooxygenases, metabolizing drugs in the parasite. a search for effective inhibitors of the enzymatic system was initiated. for this purpose inhibitory effects of 17 alpha-hydrodeoxycorticosterone (substance s), 21-acetate-17 alpha-hydroxydeoxycorticosterone (acetate of substance s), 4-bromomethyl-2,2,5,5-tetramethyl-3-imidazoline-3-oxide-1-oxyl (rbr), cu(lysine)2 on activi ... | 1985 | 3911572 |
| [drug resistance of malarial parasites and the methods for its determination]. | the problem of drug resistance of plasmodium falciparum, the causative agent of tropical malaria and its role in the general system of malaria control are discussed. the aspects of distribution of drug resistant strains of p. falciparum and the main principles of determination of the malaria causative agent sensitivity to antimalaria drugs are presented. the determination implies the use of various procedures for performing the tests under clinical conditions in vivo and various modifications of ... | 1985 | 3911876 |
| protective immunity to malaria: studies with cloned lines of plasmodium chabaudi and p. berghei in cba/ca mice. i. the effectiveness and inter- and intra-species specificity of immunity induced by infection. | cba/ca mice were immunized by infection with cloned lines of plasmodium berghei (isolates anka, ksp-11). plasmodium chabaudi chabaudi (as, cb) or plasmodium chabaudi adami (ds) and then challenged with either homologous or heterologous parasites. protective responses were assessed in immune mice relative to the controls by their ability to (i) extend the time taken for the mean parasitaemia to reach a predetermined level (1% or 0.1%) (ii) reduce peak parasitaemia (iii) resolve the parasitaemia s ... | 1985 | 3912704 |
| [development of a piperaquine-resistant line of plasmodium berghei k 173 strain]. | 1985 | 3913275 | |
| [studies on analogs of qinghaosu. vii. the synthesis of ethers of bis(dihydroqinghaosu) and bis(dihydrodeoxyqinghaosu)]. | 1985 | 3913276 | |
| [studies on antimalarials. xv. synthesis and antimalarial activities of some bis(2,4-diaminoquinazol-6-yl-substituted aminomethyl) aromatic derivatives]. | 1985 | 3913278 | |
| glucan-induced immunity in mice against plasmodium berghei. | 1985 | 3913389 | |
| [pyronaridine--a new antimalarial drug]. | 1985 | 3914406 | |
| recent advances in malaria research: parasite biology, chemotherapy and host/parasite relationships. | 1985 | 3914847 | |
| protection of athymic (nu/nu) balb/c mice against plasmodium berghei by splenocytes from normal (nu/+) balb/c mice. | 1985 | 3915397 | |
| [development of piperaquine-resistant line of plasmodium berghei anka strain]. | 1985 | 3915725 | |
| [the fine structure of the blood stages of the piperaquine-resistant line of plasmodium berghei anka strain]. | 1985 | 3915734 | |
| malaria and the liver. | 1985 | 3920137 | |
| novel anti-malarial hydroxynaphthoquinones with potent broad spectrum anti-protozoal activity. | novel hydroxynaphthoquinones are reported with outstanding efficacy against plasmodium, eimeria and theileria species. biochemical evidence is presented for the selective toxicity of these compounds being due to inhibition of parasite respiratory systems. | 1985 | 3920634 |
| hepatic acid hydrolases of albino rats, mastomys natalensis and albino mice during plasmodium berghei infection. | changes in liver acid hydrolase activities during the infection of albino rats, mastomys or mice with plasmodium berghei are described. b-glucosidase, b-galactosidase and n-acetyl-b-d-glucosaminidase exhibited widely different responses with acid phosphatase and cathepsin-b the least responsive and are likely to be causally related to immunity of animals. | 1985 | 3921400 |
| rhoptry secretion of membranous whorls by plasmodium berghei sporozoites. | electron microscopy of sporozoites of the rodent malaria parasite, plasmodium berghei, reveals electron-dense multilaminate membranous whorls within components of the rhoptry-microneme complex after fixation with tannic acid in conjunction with glutaraldehyde. this multilaminate material, which has a dark line to dark line periodicity of approximately 5 nm, appears to be secreted from the sporozoite since it is also found adhering to the sporozoite's external surface. the material may function i ... | 1985 | 3925131 |
| interactions of plasmodium berghei-infected erythrocytes with complement. | incubation of radioactively labeled parasitized (plasmodium berghei) erythrocytes (pe) with adherent peritoneal exudate cells in the presence of 10% (v/v) fresh mouse serum (nms) resulted in the uptake of a proportion of radioactive material (pe). inactivation of the added serum by heat or zymosan treatment resulted in diminished uptake of radioactivity. these results suggest that pe activated complement. incubation of fresh nms with pe reduced the hemolytic complement level of the serum as show ... | 1985 | 3925133 |
| effects of p-aminobenzoic acid, methionine, threonine and protein levels on susceptibility of mice to plasmodium berghei. | the effects of dietary p-aminobenzoic acid (paba), protein, methionine and threonine on plasmodium berghei infection in mice were investigated. animals were fed diets containing 12 or 20% casein supplemented with paba (0 or 2 mg/kg diet), methionine (0 or 15 mg/g casein) and threonine (0, 7.5, 27.5 or 47.5 mg/g casein). percent mortality was lower in rats fed diets without paba than in those fed diets containing paba. all further experiments were conducted without supplemental paba. while the me ... | 1985 | 3934351 |
| activities of the tetrahydrofuran derivative, ba-41,799, against plasmodium cynomolgi infections in rhesus monkeys. | ba-41,799, a tetrahydrofuran derivative that at one time attracted considerable interest as an antimalarial agent because of a combination of structural novelty with activities against infections with plasmodium berghei and plasmodium berghei yoelii in mice, has been evaluated for its capacities to effect prophylaxis and radical cure in rhesus monkeys challenged or already infected with sporozoites of the drug-susceptible ro strain or the pyrimethamine-resistant ro/pm strain of plasmodium cynomo ... | 1985 | 3985599 |
| 4-substituted 5-[m-(trifluoromethyl)phenoxy]primaquine analogues as potential antimalarial agents. | five 4-substituted 5-[m-(trifluoromethyl)phenoxy]primaquine analogues were synthesized and tested for radical curative activity against plasmodium cynomolgi in rhesus monkeys and for blood schizonticidal antimalarial activity against plasmodium berghei in mice. in addition, they were evaluated for causal prophylactic antimalarial activity against plasmodium berghei yoelii in mice. one compound, 4-ethyl-5-[m-(trifluoromethyl)phenoxy]primaquine (2b), showed radical curative activity equivalent to ... | 1985 | 4067985 |
| sulfur-interrupted 8-amino side chain analogues of 4-methyl-5-[m-(trifluoromethyl)phenoxy]primaquine as potential antimalarial agents. | two isomeric sulfur-interrupted 8-amino side chain analogues of 4-methyl-5-[m-(trifluoromethyl)phenoxy]primaquine (2) were prepared and tested for antimalarial activity. the compounds were evaluated for blood schizonticidal activity against plasmodium berghei in mice and radical curative activity against plasmodium cynomolgi in rhesus monkeys. in addition, they were evaluated for causal prophylactic activity against plasmodium berghei yoelii in mice. both compounds were more active and less toxi ... | 1985 | 4068013 |
| antibody levels in mice infectedwith plasmodium berghei yoelii. | 1970 | 4099406 | |
| preliminary studies on the use of ferritin-conjugated antibodies to plasmodium berghei. | 1971 | 4100660 | |
| plasmodium berghei infection in neonatallythymectomized hamsters. | 1971 | 4101132 | |
| murine malaria. 3. protein concentrations during plasmodium berghei infection. | 1971 | 4110097 | |
| supravital staining of plasmodium berghei. | 1971 | 4110489 | |
| nile blue stain: plasmodium berghei and uninfected erythrocytes. | 1972 | 4114705 | |
| antigenic studies on plasmodium berghei and their relations to genetic work. | 1972 | 4116049 | |
| an electron microscope-cytochemical method for differentiating membranes of host red cells and malaria parasites. | 1973 | 4128533 | |
| plasmodium sp.: topography of intra- and extracellular parasites. | 1973 | 4130524 | |
| surface properties of extracellular malaria parasites: morphological and cytochemical study. | morphological and cytochemical surface characteristics of isolated malaria parasites (plasmodium berghei) and host erythrocytes were compared by electron microscopy by using thin section and carbon replica techniques. erythrocytes were uniform in shape and had fine, granular surfaces. in contrast, free parasites exhibited a variety of sizes, shapes, and surface textures. fine surface stippling was a common topographical feature of isolated parasites. small, infective forms often had patterned su ... | 1974 | 4132619 |
| studies on the motility of plasmodium sporozoites. | 1974 | 4138523 | |
| antimetabolites of coenzyme q. 20. synthesis of new alkyl-5,8-quinoxalinequinones as potential inhibitors of coenzyme q and as antimalarial drugs. | 1973 | 4147839 | |
| further studies on the mitochondrial changes during the life cycle of plasmodium berghei: electrophoretic studies on isocitrate dehydrogenases. | 1973 | 4148615 | |
| citric acid cycle activity and chloroquine resistance in rodent malaria parasites: the role of the reticulocyte. | 1973 | 4148616 | |
| plasmodium berghei: mechanisms and sites of resistance to sporogonic development in different mosquitoes. | 1973 | 4149337 | |
| observations on the binding site for antimalarial schizontocides. | 1973 | 4149673 | |
| proceedings: hydrolases of the sporogonic stage of plasmodium berghei nigeriensis. | 1974 | 4150466 | |
| 8-(omega-aminoalkylamino)quinolines as potential prophylactic antimalarials. | 1974 | 4151456 | |
| observations on the sporogonic cycle of plasmodium berghei in two australasian anophelines. | 1974 | 4152304 | |
| assessment of causal prophylactic activity in plasmodium berghei yoelii and its value for the development of new antimalarial drugs. | the causal prophylactic activity of several reference and experimental antimalarial compounds was assessed in sporozoite-induced infections of nmri mice with plasmodium berghei yoelii (strain 17x). the animals were inoculated with 10 000 sporozoites per mouse and treated once 2-4 hours later. the test system has proved to be very suitable in experiments involving more than 3 000 mice. the infection rate in 448 untreated controls was 97.3%. lowering the sporozoite content of the inoculum to 1 000 ... | 1974 | 4155355 |
| the asexual and sexual circadian rhythms of plasmodium vinckei chabaudi, of p. berghei and of p. gallinaceum. | 1972 | 4156397 | |
| autoimmune reactions in rats with plasmodium berghei infection. | 1966 | 4163375 | |
| [changes in serum proteins and protective immunity in malaria (plasmodium berghei) of mice]. | 1967 | 4176064 | |
| influence of plasmodium berghei yoelii or p. chabaudi or both on the course of splenomegaly and immunoglobulins in mice. | 1969 | 4186077 |