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relationship between bacterial colonisation and the frequency, character, and severity of copd exacerbations.patients with chronic obstructive pulmonary disease (copd) are prone to frequent exacerbations which are a significant cause of morbidity and mortality. stable copd patients often have lower airway bacterial colonisation which may be an important stimulus to airway inflammation and thereby modulate exacerbation frequency.200212200518
the italian epidemiological survey 1997-1999. antimicrobial susceptibility data of haemophilus influenzae, haemophilus parainfluenzae and moraxella catarrhalis in italy.the italian epidemiological survey began a surveillance study with the aim of monitoring the antimicrobial resistance of respiratory pathogens. from 1997 to 1999, 2028 strains of haemophilus influenzae and 523 strains of haemophilus parainfluenzae were collected from 59 clinical microbiology laboratories distributed throughout italy. in 1998, the study was extended to include moraxella catarrhalis and a total of 360 isolates were collected. there was a significant increase in the beta-lactamase ...200212385682
activities of hmr 3787 and ru 64399 compared with those of four other agents against haemophilus influenzae and haemophilus parainfluenzae.activities of hmr 3787, a new 2-fluoroketolide, and its (des)-fluor derivative, ru 64399, were tested against 111 haemophilus influenzae and 26 h. parainfluenzae strains and compared with those of telithromycin, erythromycin, azithromycin, and clarithromycin. hmr 3787 and ru 64399 mics were comparable with those of azithromycin but were less affected by incubation in co(2). time-kill studies of 12 strains showed that hmr 3787, ru 64399, and telithromycin were bactericidal against all strains aft ...200312499225
nephrotic syndrome with crescent formation and massive iga deposition following allogeneic bone marrow transplantation for natural killer cell leukemia/lymphoma.we describe herein a case of nephrotic syndrome (ns) following allogeneic bone marrow transplantation (allo-bmt) for natural killer cell leukemia/lymphoma. histologic studies defined the diagnosis as crescentic glomerulonephritis with massive immunoglobulin a (iga) deposition, which has never been reported in ns cases following allo-bmt. most of the massive infiltrated cells in the interstice were cd3(+)cd4(-)cd8(+) t cells derived from the donor. we observed mesangial deposition of haemophilus ...200312543867
primary peritonitis in a child caused by haemophilus parainfluenzae.a case of primary peritonitis caused by haemophilus parainfluenzae in a previously healthy child is presented. to our knowledge, this is the first such documented case.200212598974
haemophilus parainfluenzae infection of respiratory mucosa.the pathogenicity of haemophilus parainfluenzae (hpi) in the respiratory tract is unclear, in contrast to the accepted pathogenicity of its close relative non-typable h. influenzae. we have investigated the interaction of two hpi isolates with the mucosa of adenoid and bronchial tissue organ cultures. the adherence of bacteria to the mucosa of organ cultures, the effect of broth culture filtrates on human nasal epithelium, and interleukin (il)-8 production by a549 cell cultures was investigated. ...200312693797
comparative in vitro potency of amoxycillin-clavulanic acid and four oral agents against recent north american clinical isolates from a global surveillance study.the in vitro activity of amoxycillin-clavulanic acid was compared with four comparator oral antimicrobial agents; ampicillin, azithromycin, cefuroxime and trimethoprim-sulphamethoxazole against 4536 recent clinical isolates covering 29 species isolated in the us and canada between 1997 and 1999. based upon minimum inhibitory concentrations (mics), amoxycillin-clavulanic acid was the most active agent against many gram-positive species and phenotypes including methicillin susceptible staphylococc ...200312727075
microbial population diversity in the urethras of healthy males and males suffering from nonchlamydial, nongonococcal urethritis.nonchlamydial, nongonococcal urethritis (ncngu) is suggested to be a sexually transmitted disease in men. ncngu patients were compared to control subjects with regard to the presence of potentially infectious bacteria in the first void urine. patients' pre- and post-antibiotic-treatment urine samples and two samples obtained 2 weeks apart from healthy volunteers, who did not receive antibiotic therapy, were analyzed with broad-spectrum pcr tests aiming at eubacterial small subunit rrna genes. re ...200312734237
hacek endocarditis in infants and children: two cases and a literature review.we report 2 cases of haemophilus parainfluenzae endocarditis and review 34 cases of hacek endocarditis from the literature. hacek organisms are the most common cause of gram-negative endocarditis in children. they have a propensity to form friable vegetations (especially h. parainfluenzae) that break off and cause symptomatic emboli. hacek endocarditis (from a review of the 36 published cases) may involve previously normal hearts (33%), may be complicated by embolization (31%) and may require ve ...200312799515
[colecystitis caused by haemophilus parainfluenzae. description of a case]. 200112876595
infective endocarditis after oral body piercing.body piercing has become an increasingly common practice in the united states and elsewhere. although perceived as a relatively safe practice, it poses the risk of numerous infectious complications. oral body piercing in particular has significant potential risk given the known relationship of oral flora to bacteremia. we describe a patient who developed infective endocarditis shortly after undergoing oral piercing.200312943601
a defined medium for haemophilus influenzae and haemophilus parainfluenzae. 196213875197
cytochrome and catalase patterns during growth of haemophilus parainfluenzae.white, david c. (the rockefeller institute, new york, n. y.) cytochrome and catalase patterns during growth of haemophilus parainfluenzae. j. bacteriol. 83:851-859. 1962.-by following the cytochrome and catalase concentrations during the growth cycle and under various growth conditions in haemophilus parainfluenzae, a rapid increase in the cytochrome oxidases and a large increase in cytochrome c(1) concentration can be demonstrated between log-phase and stationary-phase cells and between vigorou ...196214006506
effect of interspecific transformation on linkage relationships of markers in haemophilus influenzae and haemophilus parainfluenzae.nickel, lois (university of pennsylvania, philadelphia), and sol h. goodgal. effect of interspecific transformation on linkage relationships of markers in haemophilus influenzae and haemophilus parainfluenzae. j. bacteriol. 88:1538-1544. 1964.-highly competent cells of haemophilus parainfluenzae were obtained by a modification of the aerobic-"anaerobic" method of goodgal and herriott. the mutant markers for streptomycin and novobiocin resistance in h. parainfluenzae were shown to be unlinked. th ...196414240934
synthesis of 2-demethyl vitamin k2 and the cytochrome system in haemophilus.white, david c. (university of kentucky college of medicine, lexington). synthesis of 2-demethyl vitamin k(2) and the cytochrome system in haemophilus. j. bacteriol. 89:299-305. 1965.-the synthesis of the respiratory quinone, 2-demethyl vitamin k(2), is stimulated in haemophilus parainfluenzae under conditions which provoke the synthesis of the cytochrome system. however, the various components of the electron-transport system can be formed in different proportions. the primary flavoprotein dehy ...196514255694
subacute bacterial endocarditis due to haemophilus parainfluenzae. 196514312695
growth response of a strain of haemophilus parainfluenzae to menadione (vitamin k3). 196214464456
activities of a new oral streptogramin, xrp 2868, compared to those of other agents against streptococcus pneumoniae and haemophilus species.mic methodology was used to test the antibacterial activity of xrp 2868, a new oral combination of two semisynthetic streptogramins, rpr 132552a and rpr 202868, compared to activities of other antibacterial agents against pneumococci, haemophilus influenzae, and haemophilus parainfluenzae. for 261 pneumococci, xrp 2868 and pristinamycin mics were similar, irrespective of penicillin g and erythromycin a susceptibilities (mic at which 50% of isolates were inhibited [mic(50)], 0.25 micro g/ml; mic( ...200314506040
a 2-year-old girl with a several-day history of vomiting and lethargy. 200314508890
amoxicillin/clavulanate potassium extended release tablets: a new antimicrobial for the treatment of acute bacterial sinusitis and community-acquired pneumonia.community-acquired bacterial respiratory tract infections are among the most common health disorders requiring medical care and are associated with substantial morbidity, mortality, and direct and indirect costs. recent increases in the prevalence of antimicrobial resistance have resulted in reduced susceptibility of the most common respiratory tract bacterial pathogens to a number of antimicrobials. amoxicillin/clavulanate potassium extended release (er) tablets (augmentin xr, glaxosmithkline) ...200314521493
[monoarthritis with haemophilus parainfluenzae septicaemia during multiple myeloma of the bones]. 200314534478
susceptibilities of fluoroquinolone-resistant haemophilus parainfluenzae isolates from japanese patients with respiratory infections to five fluoroquinolones and other antimicrobial agents. 200314638520
haemophilus parainfluenzae: an underdiagnosed pathogen of biliary tract infections?presented here is a case of monobacterial peritonitis complicating cholecystitis and caused by an uncommon agent of gastrointestinal infections, haemophilus parainfluenzae. the pathogenic role of this organism in digestive infections, particularly in those of the biliary tract, has been reported increasingly though sporadically. indeed, it has been shown to be a coloniser of the gastrointestinal tract, and a recent hypothesis of an ascending route of infection to the biliary tract has been postu ...200414669072
etiological agents of lower respiratory tract infections in japanese children.to investigate the etiology of pediatric community-acquired pneumonia and bronchitis, we conducted a prospective, population-based study covering the total population < 15 years of age in 16 municipalities in hokkaido, japan, during the period of april 2000 to march 2001. chest radiographs were available for all cases (n = 921; 398 as pneumonia and 523 as bronchitis) and paired sera for serologic assays were available for more than half of the cases. the following specimens were also collected: ...200415011754
antimicrobial susceptibility of haemophilus influenzae, haemophilus parainfluenzae and moraxella catarrhalis isolated from adult patients with respiratory tract infections in four southern european countries. the arise project.over a 7-month period in 2000-2001, 1213 haemophilus influenzae, 112 haemophilus parainfluenzae and 142 moraxella catarrhalis isolates were recovered from adult patients with respiratory tract infections. patients were from four southern european countries (spain, italy, portugal and greece). the antimicrobial susceptibility of the isolates to 11 antibiotics was determined in a central laboratory. the most active drugs on the basis of mics were levofloxacin, cefditoren, cefotaxime, cefpodoxime a ...200415164972
pacemaker lead infection secondary to haemophilus parainfluenzae.cardiac device infections are a rare complication of pacing and defibrillator therapy. the number of implanted devices will likely continue to rise with increasing implantation of the cardioverter defibrillator and cardiac resynchronization devices. this report describes a case of an uncommon pathogen for device-associated endocarditis.200415271026
dna-based subtypes and antimicrobial susceptibility profiles of haemophilus influenzae and haemophilus parainfluenzae isolated from different tonsillar sites of children undergoing tonsillectomy and/or adenoidectomy.we did a comparative analysis between dna-based subtypes and antimicrobial susceptibility profiles on haemophilus influenzae and haemophilus parainfluenzae, isolated from multiple tonsillar sites per individual from patients with chronic recurrent tonsillitis and/or tonsillar idiopathic hypertrophy and undergoing tonsillectomy and/or adenoidectomy. a total of eighty-eight haemophilus isolates were obtained aseptically from the surface and core of tonsils and/or adenoids of 32 out of 60 patients ...200215298475
microbial etiologies in community acquired pneumonia (cap).the objective of the study was determination of bacterial etiologic factors, including antibiotic atypical pathogens, of community acquired pneumonia (cap) in adults and of sensitivity of isolated strains. the examined group comprised 50 patients with clinical and x-ray image of pneumonia. patients' expectoration sputum was analyzed. amongst all isolated bacteria, the most frequent were staphylococcus aureus - 17.9%, haemophilus parainfluenzae - 12.5% and h. influenzae - 8.9%. identification of ...200315315033
bacterial exacerbations of chronic obstructive pulmonary disease. the role of lung function in aetiology of exacerbation.the objective of the study was determination of the most frequent bacterial factors, including haemophilus parainfluenzae, suspected of causing copd exacerbation, of the relation between bacterial strains and respiratory system functional status as well as of antibiotic sensitivity of sputum isolated bacteria. the examined group comprised 28 patients treated in the pulmonary department of medical university of lublin. the subjects fulfilled the criteria of type i copd bacterial exacerbation. pat ...200315315034
[piercing and tattoos in patients with congenital heart disease -- is it a problem?].piercing and tattooing enjoy widespread popularity in modern society. patients with congenital heart disease are at elevated risk for infective endocarditis. however, it is not yet known whether piercing and tattooing are dangerous for these patients.a search of the literature provided 10 published cases of infective endocarditis after piercing or tattooing. affected patients were adolescents or young adults ranging in age from 13 to 30 years (5 male, 5 female). four of the patients had a known ...200415338148
["actinobacillus and haemophilus parainfluenzae infective endocarditis: two case reports"]. 200415363627
emergence and persistence of macrolide resistance in oropharyngeal flora and elimination of nasal carriage of staphylococcus aureus after therapy with slow-release clarithromycin: a randomized, double-blind, placebo-controlled study.to investigate the effect of slow-release (sr) clarithromycin on colonization and the development of resistance in oropharyngeal and nasal flora, a double-blind, randomized, placebo-controlled trial was performed with 8 weeks of follow-up. a total of 296 patients with documented coronary artery disease were randomized in the preoperative outpatient clinic to receive a daily dose of sr clarithromycin (500 mg) (cl group) or placebo tablets (pb group) until the day of surgery. nose and throat swabs ...200415504839
population pharmacokinetics and pharmacodynamics of garenoxacin in patients with community-acquired respiratory tract infections.garenoxacin (t-3811me, bms-284756) is a novel, broad-spectrum des-f(6) quinolone currently under study for the treatment of community-acquired respiratory tract infections. this analysis assessed garenoxacin population pharmacokinetics and exposure-response relationships for safety (adverse effects [ae]) and antimicrobial activity (clinical cure and bacteriologic eradication of streptococcus pneumoniae and the grouping of haemophilus influenzae, haemophilus parainfluenzae, and moraxella catarrha ...200415561855
efficacy and safety of pharmacokinetically enhanced amoxicillin-clavulanate at 2,000/125 milligrams twice daily for 5 days versus amoxicillin-clavulanate at 875/125 milligrams twice daily for 7 days in the treatment of acute exacerbations of chronic bronchitis.this randomized, controlled trial was designed to show that a short, 5-day course of pharmacokinetically enhanced amoxicillin-clavulanate at 2,000/125 mg (augmentin xr) is as effective clinically as a longer, 7-day course of conventional amoxicillin-clavulanate at 875/125 mg (both given twice daily) in the treatment of acute exacerbations of chronic bronchitis (aecb). amoxicillin-clavulanate at 2,000/125 mg was designed to extend the therapeutic levels of amoxicillin in serum over the 12-h dosin ...200515616290
multilocus sequence phylogenetic study of the genus haemophilus with description of haemophilus pittmaniae sp. nov.the phylogeny of human isolates of haemophilus species was estimated based on partial sequences of four separate housekeeping genes. the clustering of each set of sequences was in accordance with speciation of the strains with few exceptions: of 108 gene fragments examined, only three appeared to have been subject to recombination events across the species barrier. housekeeping gene similarity supported previous dna-dna hybridization data for the genus rather than the phylogeny inferred from 16s ...200515653917
haemophilus parainfluenzae mitral prosthetic valve endocarditis in an intravenous drug abuser.haemophilus species are an infrequent cause of subacute bacterial endocarditis. of the haemophilus species causing endocarditis, h. aphrophilus and h. parainfluenzae are more frequent causes of subacute bacterial endocarditis than h. influenzae. h. parainfluenzae requires growth factor v (nicotinamide adenine dinucleotide) and grows very slowly on routine culture media. h. parainfluenzae is a rare cause of "culture negative" endocarditis because it is a slow-growing organism. we present a case o ...200515761462
in vitro investigation of the indirect pathogenicity of beta-lactamase-producing microorganisms in the nasopharyngeal microflora.nasopharyngeal microflora contains some beta-lactamase-producing microorganisms. in this study, we investigated in vitro on the indirect pathogenicities of haemophilus parainfluenzae (h. parainfluenzae) and moraxella catarrhalis (m. catarrhalis) against the antipneumococcul activities of some beta-lactams.200515763284
infection of haemophilus parainfluenzae in tonsils is associated with iga nephropathy.we investigated the functions of tonsillar mononuclear cells (tmc) regarding whether a haemophilus parainfluenzae (hp) outer membranes antigen (hpom) enhances iga-related cytokine (ifn-gamma, il-10. and tgf-beta) production in vitro by tmc in iga nephropathy (igan) patients. in addition, we examined the effect of synthetic oligodeoxynucleotide and hpom stimulation by tmc on iga production, whether the constant region antisense to iga inhibits the production of iga in vitro by tmc. eighteen patie ...200415768791
[solitary abscessing osteomyelitis of the mandibular condyle. a rarity].we report on a rare case of secondary chronic osteomyelitis of the left condyle. haemophilus aphrophilus could be isolated from the abscess material. the condyle was resected and reconstructed with an endoprosthesis in the same operation.200515965774
the sentinel project: an update on the prevalence of antimicrobial resistance in community-acquired respiratory streptococcus pneumoniae and haemophilus spp. in italy.a total of 460 streptococcus pneumoniae and haemophilus spp. collected from respiratory infections during 2000 was tested for their susceptibility to 15 selected antibiotics. overall, penicillin resistance among pneumococci was 10.5%, while lack of susceptibility to macrolides, co-trimoxazole, tetracycline and chloramphenicol reached 35.2%, 26.2%, 22.6% and 6.0%, respectively. amoxicillin/clavulanic acid and levofloxacin were the most potent compounds (100% and 99.9% susceptible strains, respect ...200515967638
esophageal lesions: risk factors for the development of brain abscess? 200516012025
abdominal pain and fever in an adolescent. 200516210103
molecular characterization of a pre-columbian mummy and in situ coprolite.the history of homo sapiens dispersal around the world and inherent interpopulation contacts and conflicts has given rise to several transitions in his relationships with the natural world, with the final result of changes in the patterns of infectious disease (mcmichael [2001] ecosystem health 7:107-115). of particular interest, in this context, is the contact between amerindians and europeans that started at the end of the 15th century, and the resulting exchange of microbes. we successfully r ...200616342258
[bacterial tracheitis as the cause of acute respiratory insufficiency in 2 teenagers].a 13-year-old girl and a 12-year-old boy developed acute respiratory insufficiency caused by an upper airway obstruction, which necessitated intubation and mechanical ventilation. cultures from throat swabs from the girl and boy yielded haemophilus parainfluenzae and streptococcus pneumoniae, respectively. diagnoses of bacterial tracheitis were confirmed by tracheoscopy and both children were treated with antibiotics. after 11 and 4 days of mechanical ventilation, respectively, they were success ...200616538845
septic peripheral embolization from haemophilus parainfluenzae endocarditis. 200616632678
[infection pathogen analysis of 2388 patients in an open hematology ward from 1993 to 2004].to investigate the incidence of infection and pathogens in hematology ward.200616681921
invasive haemophilus parainfluenzae maternal-infant infections: an australasian perspective and case report.maternal and neonatal infection with haemophilus parainfluenzae is an unusual but potentially life-threatening occurrence. we present a case of h. parainfluenzae complicating pregnancy in the second trimester. predisposing factors for infection with haemophilus species and australasian data on invasive neonatal haemophilus infections are presented.200616704486
antibacterial activity of propolis and its active principles alone and in combination with macrolides, beta-lactams and fluoroquinolones against microorganisms responsible for respiratory infections.propolis is produced by bees and is reported to have several pharmaceutical properties. its antibacterial activity against strains causing upper respiratory tract infections is particularly important: propolis might be used as a therapeutic agent to prevent the bacterial infections that sometimes overlap viral infections. in this study the in vitro activity of both an alcoholic solution and a hydroglyceric extract of propolis, as well as its active principles, was tested against bacteria respons ...200616736885
cardiobacterium hominis endocarditis: two cases and a review of the literature.cardiobacterium hominis, a member of the hacek group (haemophilus parainfluenzae, haemophilus aphrophilus, and haemophilus paraphrophilus, actinobacillus actinomycetemcomitans, c. hominis, eikenella corrodens, and kingella species), is a rare cause of endocarditis. there are 61 reported cases of c. hominis infective endocarditis in the english-language literature, 15 of which involved prosthetic valve endocarditis. there is one reported case of c. hominis after upper endoscopy and none reported ...200616955250
[a case of pulmonary abscess in which haemophilus parainfluenzae and streptococcus intermedius were isolated by percutaneous needle aspiration].some microbes, including the bacteroides species, staphylococcus aureus and streptococcus milleri groups, can cause pulmonary abscess. haemophilus parainfluenzae is usually categorized as one of the normal flora which colonizes in the ears and the nasopharynx, and it has been long considered that h. parainfluenzae has little pathogenicity in the lower respiratory tract and lung parenchymal. in this report, we present a case of pulmonary abscess caused by both h. parainfluenzae and streptococcus ...200616972613
the soda gene as a target for phylogenetic dissection of the genus haemophilus and accurate identification of human clinical isolates.the genus haemophilus constitutes a heterogeneous group of pasteurellaceae species, and conventional identification of isolates other than haemophilus influenzae and haemophilus parainfluenzae is often challenging. here, simple colony-pcr and sequencing assays with the same pair of degenerate primers were used to characterize a 449- to 458-bp fragment (soda(int)) internal to the soda gene encoding the manganese-dependent superoxide dismutase in type strains of all 15 haemophilus species and acti ...200617049306
efficacy and safety of 3-day azithromycin versus 5-day moxifloxacin for the treatment of acute bacterial exacerbations of chronic bronchitis.antibiotic therapy is of clinical benefit in certain patients with acute exacerbations of chronic bronchitis (aecb). in this randomised, investigator-blinded, multicentre trial, azithromycin (500mg once a day (qd) for 3 days) was compared with moxifloxacin (400mg qd for 5 days) for the treatment of outpatients with aecb (forced expiratory volume in 1s (fev(1)) >35%). of 342 patients randomised to either treatment, 169 received azithromycin and 173 received moxifloxacin. the mean age in the azith ...200717189096
detection of haemophilus influenzae by loop-mediated isothermal amplification (lamp) of the outer membrane protein p6 gene.it is difficult and time-consuming to distinguish haemophilus influenzae from the genotypically similar haemophilus parainfluenzae, which is a commensal of the human oral cavity. the novel nucleic acid amplification technique of loop-mediated isothermal amplification (lamp), which amplifies dna under isothermal conditions (63 degrees c) with high specificity, efficiency, and rapidity, was evaluated for h. influenzae detection. a h. influenzae-specific lamp primer set was designed for the outer m ...200717314429
spontaneous bacterial peritonitis caused by haemophilus parainfluenzae. 200717402331
patterns and dynamics of airway colonisation in mechanically-ventilated patients.the aim of this study was to investigate the patterns and dynamics of the microbiota in the airways of ventilated patients. seventy-four mechanically-ventilated patients were recruited consecutively, and oropharyngeal, tracheal and bronchoalveolar (bal) fluid specimens were collected 48 h after intubation, and every 72 h thereafter until the patient was extubated or a total of five sample sets had been collected. ventilator-associated pneumonia (vap) pathogens were identified, quantified and gen ...200717430338
biochemical characterization and phylogenetic analysis based on 16s rrna sequences for v-factor dependent members of pasteurellaceae derived from laboratory rats.phylogenetic analysis based on 16s rrna sequences with sequence data of some bacterial species of pasteurellaceae related to rodents deposited in genbank was performed along with biochemical characterization for the 20 strains of v-factor dependent members of pasteurellaceae derived from laboratory rats to obtain basic information and to investigate the taxonomic positions. the results of biochemical tests for all strains were identical except for three tests, the ornithine decarboxylase test, a ...200717487533
diversity of antibiotic resistance integrative and conjugative elements among haemophili.the objective of this study was to investigate the sequence diversity in a single country of a family of integrative and conjugative elements (ices) that are vectors of antibiotic resistance in haemophilus influenzae and haemophilus parainfluenzae, and test the hypothesis that they emerged from a single lineage. sixty subjects aged 9 months - 13 years were recruited and oropharyngeal samples cultured. up to 10 morphologically distinct pasteurellaceae spp. were purified, and then the species were ...200717510272
urinary tract infection caused by haemophilus influenzae and haemophilus parainfluenzae in children.there are few reports on urinary tract infections caused by haemophilus influenzae or haemophilus parainfluenzae in children. the true incidence is not known, since bacteria of haemophilus species do not grow in standard urine culture media. with the objective of investigating the occurrence and character of urinary tract infections (utis) caused by haemophilus bacteria in children, we searched the files of our uti clinic. over a 24-year period 36 children with haemophilus spp. bacteriuria were ...200717541792
[haemophilus parainfluenzae--a rare cause of endocarditis].haemophilus parainfluenzae endocarditis is a rare acute or subacute disease. it is usually associated with dental and surgical procedures in the oral cavity. in a 23-year-old athlete admitted to department of infectious diseases, split university hospital, the diagnosis of infective endocarditis was established based on duke's criteria. the patient was not exposed to risky medical procedures nor he had a predisposing heart disease. the course of illness was characterized by peripheral embolizati ...200717585482
[study on the relationship between airway bacterial infections and acute exacerbations in patients with chronic obstructive pulmonary disease].the purpose of this study was to observe the bacterial infections of respiratory tract in patients with acute exacerbation of chronic obstructive pulmonary disease (aecopd).200717877185
comparison of three commercial test systems for biotyping haemophilus influenzae and haemophilus parainfluenzae.the biotypes of haemophilus influenzae and haemophilus parainfluenzae isolates were determined with three commercially available biochemical test kits: the ids rapid nh system, the neisseria-haemophilus identification test (nhi card), and the api nh strip. the api nh strip performed best, correctly classifying the biotypes of 371 of 380 (97.6%) different challenge strains.200717942653
[drug susceptibility of haemophilus sp. and staphylococcus aureus strains colonizing respiratory tract in children with mucoviscidosis].objective: the aim of our studies was to isolate haemophili rods and s. aureus from children with mucoviscidosis and to assess antimicrobial agent susceptibility of the isolates. methods: sputa and nasopharynx swabs from 12 children with mucoviscidosis were screened for the prevalence ofhaemophilus sp. and s. aureus. susceptibility to antimicrobial agents was performed by agar diffusion method using appropriate media. beta-lactamase activity was determined with the nitrocefin discs, macrolide-li ...200717956057
selective expansion of t cell receptor (tcr) v beta 6 in tonsillar and peripheral blood t cells and its induction by in vitro stimulation with haemophilus parainfluenzae in patients with iga nephropathy.iga nephropathy (igan), the most common form of primary glomerulonephritis, is recognized as a disease that often becomes worse during acute tonsillitis. although many reports have shown that tonsillectomy is an effective treatment for igan patients, the immunological evidence has not yet been investigated fully. in this study, we compared the expression of t cell receptor (tcr) v beta families in tonsillar t cells of igan patients to those of non-igan patients. the reverse transcription-polymer ...200817983447
reduction of periodontal pathogens adhesion by antagonistic strains.periodontitis results from a shift in the subgingival microflora into a more pathogenic direction with porphyromonas gingivalis, prevotella intermedia, and actinobacillus actinomycetemcomitans considered as periodontopathogens. in many cases, treatment procures only a temporary shift towards a less pathogenic microflora. an alternative treatment could be the deliberate colonization of pockets with antagonistic microorganisms to control the adhesion of periodontopathogens. the aim of this study w ...200818173797
characterization of extended-spectrum beta-lactamase-producing isolates of haemophilus parainfluenzae.to characterize the beta-lactam resistance mechanisms of two clinical isolates of cefotaxime-resistant haemophilus parainfluenzae recovered from patients in south africa.200818245789
endocarditis after use of tongue scraper. 200718252139
an evaluation of extended incubation time with blind subculture of blood cultures in patients with suspected endocarditis.in a small proportion of patients, bacterial endocarditis is due to organisms that grow slowly and may not be recovered in conventional blood cultures incubated for five days. this has led to recommendations for prolonged incubation and routine subculture of negative cultures.200618418498
not the usual cardiac rhythm device infection: a fastidious pathogen with several teaching points.because cardiac device infections may include fastidious pathogens, extended incubation of blood cultures is suggested. a patient with an infection of a right ventricular lead implantable cardioverter defibrillator (icd) system is described. the device was implanted 6 months earlier. the pathogen was identified as haemophilus parainfluenzae, which was cultured within 72 hours and was presumably from a respiratory tract infection. extended incubation was not necessary to culture this fastidious p ...200818438798
[urethritis associated with conjunctivitis following sexual risk behavior]. 200818588821
[distribution and drug resistance of the isolated bacteria from children with acute respiratory infection].to study the distribution and drug resistance of the isolated bacteria from children with acute respiratory infection (ari) in dalian.200818947473
structural characterization of haemophilus parainfluenzae lipooligosaccharide and elucidation of its role in adherence using an outer core mutant.the opportunistic pathogen haemophilus parainfluenzae is a gram-negative bacterium found in the oropharynx of humans. haemophilus parainfluenzae is a member of the pasteurellaceae family in which it is most closely related to haemophilus sengis and actinobacillus. characterization of surface displayed lipooligosaccharide has identified components that are crucial in adherence. we examined the oligosaccharide structure of lipooligosaccharide from 2 clinical isolates of h. parainfluenzae. core oli ...200818997847
assessment of the bioequivalence of two formulations of clarithromycin extended-release 500-mg tablets under fasting and fed conditions: a single-dose, randomized, open-label, two-period, two-way crossover study in healthy jordanian male volunteers.clarithromycin extended-release tablets are indicated for the treatment of adults with acute maxillary sinusitis caused by haemophilus influenzae, moraxella catarrhalis, or streptococcus pneumoniae; acute bacterial exacerbation of chronic bronchitis due to h influenzae, haemophilus parainfluenzae, m catarrhalis, or s pneumoniae; or community acquired pneumonia due to h influenzae, h parainfluenzae, m catarrhalis, s pneumoniae, chlamydia pneumoniae, or mycoplasma pneumoniae.200819014838
delineation of the species haemophilus influenzae by phenotype, multilocus sequence phylogeny, and detection of marker genes.to obtain more information on the much-debated definition of prokaryotic species, we investigated the borders of haemophilus influenzae by comparative analysis of h. influenzae reference strains with closely related bacteria including strains assigned to haemophilus haemolyticus, cryptic genospecies biotype iv, and the never formally validated species "haemophilus intermedius". multilocus sequence phylogeny based on six housekeeping genes separated a cluster encompassing the type and the referen ...200919060144
structural basis of heme binding in the cu,zn superoxide dismutase from haemophilus ducreyi.the cu,zn superoxide dismutase from haemophilus ducreyi is characterized by the unique ability to bind heme at its dimer interface. here we report the high-resolution crystal structures of this protein in the heme-loaded (holo) and heme-free (apo) forms. heme is asymmetrically bound between the two enzyme subunits, where heme iron is coordinated by two histidine residues, his64 and his 124, provided by the two subunits. moreover, the binding of heme to the protein is ensured by stabilizing conta ...200919103206
in vitro potency of doripenem tested against an international collection of rarely isolated bacterial pathogens.doripenem, a new 1beta-methyl parenteral carbapenem, has very broad-spectrum activity against gram-positive and gram-negative aerobic bacteria. as noted here, the spectrum and potency extended to many rarely isolated species sampled by the doripenem global surveillance program. among the species or species groups with <or=0.14% prevalence (1959 strains tested), doripenem was active against 98.9% of enterobacteriaceae at <or=0.5 microg/ml. similarly, more than 90% of other rarely isolated gram-ne ...200919302927
tricuspid valve endocarditis caused by haemophilus parainfluenzae: a case report and review of the literature.haemophilus parainfluenzae is a gram-negative bacterium that is often difficult to isolate and identify. we report a rare case of tricuspid valve and pacemaker endocarditis caused by this organism and explore factors related to etiopathogenesis, prevention, and treatment.200919376668
haemophilus parainfluenzae meningitis in an adult associated with acute otitis media.a case of haemophilus parainfluenzae meningitis in a woman with a 3-day history of acute otitis media is reported. her medical history included bladder cancer surgery. unequivocal identification of the isolate was obtained by using molecular techniques such as 16s rrna sequencing besides to conventional culture methods. to investigate bacterial virulent traits possibly related to invasive properties, in vitro serum resistance of our isolate was analyzed, but it was found serum susceptible. our s ...200919579703
variability and effects of bronchial colonisation in patients with moderate copd.sputum and lung function were periodically assessed in stable moderate chronic obstructive pulmonary disease (copd) outpatients to determine relationships between bronchial colonisation and inflammation. relationships between potentially pathogenic microorganism (ppm) typology, bronchial inflammation (neutrophilia, tumour necrosis factor-alpha, interleukin (il)-1beta, il-6, il-8, il-10 and il-12) and post-bronchodilator decline in forced expiratory volume in 1 s (fev(1)) were analysed. ppms peri ...201019643939
comparisons of subgingival microbial profiles of refractory periodontitis, severe periodontitis, and periodontal health using the human oral microbe identification microarray.this study compared the subgingival microbiota of subjects with refractory periodontitis (rp) to those in subjects with treatable periodontitis (grs = good responders) or periodontal health (ph) using the human oral microbe identification microarray (homim).200919722792
a sixty-five-year-old female with pneumonia, endocarditis and meningitis. 200919750817
acute haemophilus parainfluenzae endocarditis: a case report.numerous pathogens can cause infective endocarditis, including haemophilus parainfluenzae. h. parainfluenzae is part of the h. aphrophilus, actinobacillus actinomycetemcomitans, cardiobacterium hominis, eikenella corrodens, and kingella kingae group that may cause about 3% of the total endocarditis cases, and is characterized by a subacute course and large vegetations.200919830211
[an adult case of haemophilus parainfluenzae bacteremia and meningitis].a case of bacteremia and meningitis caused by haemophilus parainfluenzae in an adult patient without known immunodeficiency and normal complement system is presented. h. parainfluenzae has not previously been reported as the cause of meningitis in denmark. patients with invasive h. parainfluenzae infection should be examined for complement factor 7 defect.201020056099
nxl-103, a combination of flopristin and linopristin, for the potential treatment of bacterial infections including community-acquired pneumonia and mrsa.novexel is developing the novel, orally active, semisynthetic streptogramin nxl-103, which has potential therapeutic application in the treatment of community-acquired pneumonia, community- or hospital-acquired mrsa, vancomycin-resistant enterococcus, and acute bacterial skin and soft tissue infections. nxl-103 is a combination of streptogramin a:streptogramin b components, initially developed in a 70:30 dose ratio. in multiple in vitro studies, nxl-103 demonstrated potent activity against diffe ...201020112172
[rare cause of severe disease]. 201020125206
antimicrobial characterisation of cem-101 activity against respiratory tract pathogens, including multidrug-resistant pneumococcal serogroup 19a isolates.cem-101 is a novel fluorinated macrolide-ketolide with potent activity against bacterial pathogens that are susceptible or resistant to other macrolide-lincosamide-streptogramin b (mls(b))-ketolide agents. cem-101 is being developed for oral and parenteral use in moderate to moderately severe community-acquired bacterial pneumonia. the objective of this study was to assess the activity of cem-101 and comparators against contemporary respiratory tract infection (rti) isolates. a worldwide sample ...201020211548
[frequency of haemophilus spp. in urinary and and genital tract samples].to determine the prevalence and antibiotic susceptibility of haemophilus influenzae and h. parainfluenzae isolated from the urinary and genital tracts.201020387727
acromioclavicular septic arthritis: a case report of a novel pathogen.in immunocompetent patients, septic arthritis of the acromioclavicular (ac) joint is a rare entity. it can be difficult to discern from glenohumeral septic arthritis and ac joint impingement syndrome. the usual symptoms are fever, erythema, swelling, palpable pain over the ac joint, and pain with shoulder motion. the most commonly reported causative organism is a staphylococcus or streptococcus species. haemophilus parainfluenzae is a rare cause of septic arthritis in any joint. although limited ...201020463985
a retroperitoneal abscess caused by haemophilus parainfluenza after endoscopic retrograde cholangiopancreatography and open cholecystectomy with a common bile duct exploration: a case report.abstract:201020525289
construction of a novel shuttle vector for use in haemophilus influenzae and h. parainfluenzae.haemophilus influenzae is an important human pathogen. a number of complete genome sequences of various haemophili are available; however, functional studies have been limited by the lack of an effective shuttle vector which functions in all strains. here, we have constructed a shuttle vector, pej6, which transfers genes between escherichia coli and h. influenzae and h. parainfluenzae. the vector contains an origin of replication from pls88 which is functional in e. coli and h. influenzae. in ad ...201020849885
molecular characterization of high-level fluoroquinolone resistance in a clinical isolate of haemophilus parainfluenzae. 201021127039
identification of bacterial dna in noninfectious pleural fluid with a highly sensitive pcr method.background: bacterial dna due to bacterial translocation has been identified in noninfectious ascitic fluid samples. objective: this study investigated the possible presence of bacterial dna in the pleural fluid of patients with pleural effusions of noninfectious origin, using a highly sensitive pcr-based method. methods: pleural fluid samples from 175 patients (average age ± sd: 69 ± 14 years) with noninfectious pleural effusion (62 transudates, 113 exudates) were analyzed. bacterial dna was de ...201021178326
pneumatosis intestinalis and mesenteric venous gas - a manifestation of bacterascites in a patient with cirrhosis.we herein report a patient with decompensated cirrhosis secondary to autoimmune hepatitis, who presented with pneumatosis intestinalis (pi) and portal venous gas. mesenteric ischemia has been recognized as a common and life-threatening cause of pi which portends a grave prognosis. the patient was found to have bacterascites and recovered after appropriate antibiotic therapy. spontaneous bacterial peritonitis/bacterascites with gas-forming organisms manifesting as pi has not been previously repor ...201121206125
identification of hacek clinical isolates by matrix-assisted laser desorption ionization-time of flight mass spectrometry.matrix-assisted laser desorption ionization-time of flight (maldi-tof) mass spectrometry is a rapid and accurate tool for the identification of many microorganisms. we assessed this technology for the identification of 103 haemophilus parainfluenzae, aggregatibacter aphrophilus, aggregatibacter actinomycetemcomitans, cardiobacterium hominis, eikenella corrodens, and kingella kingae (hacek) clinical isolates and 20 haemophilus influenzae clinical isolates. ninety-three percent of hacek organisms ...201121227988
haemophilus parainfluenzae infective endocarditis associated with pelvic abscess: an uncommon complication of endometriosis.the case of a woman with native mitral valve endocarditis due to haemophilus parainfluenzae (hpi) associated with a pelvic abscess and endometriosis is reported. although hpi is an infrequent pathogen involved in endocarditis, association to a gynaecological infection has never been reported. endometriosis could increase this risk.201021355469
genetic detection of quinolone resistance in haemophilus parainfluenzae: mutations in the quinolone resistance-determining regions of gyra and parc.the quinolone resistance-determining regions of gyra and parc of both quinolone-sensitive and quinolone-resistant haemophilus parainfluenzae strains were amplified and sequenced. similar to haemophilus influenzae, resistance to quinolones in h parainfluenzae is associated with mutations in the quinolone resistance-determining regions of both gyra and parc. the present study discusses the importance of this finding.201021358875
medical microbiologythe genus haemophilus includes a number of species that cause a wide variety of infections but share a common morphology and a requirement for blood-derived factors during growth that has given the genus its name. haemophilus influenzae, the major pathogen, can be separated into encapsulated or typable strains, of which there are seven types (a through f including e') based on the antigenic structure of the capsular polysaccharide, and unencapsulated or nontypable strains. type b h influenzae is ...199621413340
haemophilus parainfluenzae septic arthritis: report of a case and review of the literature. 201121507531
establishing diagnosis of haemophilus parainfluenzae as etiology of culture-negative endocarditis using dna sequence analysis on tissue specimen. 201121683823
evaluation of commercial universal rrna gene pcr plus sequencing tests for identification of bacteria and fungi associated with infectious endocarditis.two new commercially available universal rrna gene pcr plus sequencing tests, sepsitest and universal microbe detection (umd; molzym, bremen, germany), were evaluated using blood specimens and heart valves from 30 patients with suspected infectious endocarditis (ie). the sensitivity of pcr (85%) was nearly twice as high as that of culture (45%), which in 10/20 ie cases presumably stayed negative as a consequence of growth inhibition of the pathogens by antibiotics. further, pcr provided the basi ...201121715592
gastrointestinal microbiome signatures of pediatric patients with irritable bowel syndrome.background & aims: the intestinal microbiomes of healthy children and pediatric patients with irritable bowel syndrome (ibs) are not well defined. studies in adults have indicated that the gastrointestinal microbiota could be involved in ibs. methods: we analyzed 71 samples from 22 children with ibs (pediatric rome iii criteria) and 22 healthy children, ages 7-12 years, by 16s ribosomal rna gene sequencing, with an average of 54,287 reads/stool sample (average 454 read length = 503 bases). data ...201121741921
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