Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| neuronal interactions between neuropeptide y (npy) and catecholaminergic systems in the rat arcuate nucleus as shown by dual immunocytochemistry. | several recent studies have suggested interactions between catecholamine (ca) and neuropeptide y (npy) neuronal systems in the rat brain. in order to obtain morphological evidence for such ca/npy interactions in the arcuate nucleus, we have used a double immunostaining procedure using an anti-tyrosine hydroxylase (th) antiserum as a marker for catecholamine neurons and an anti-npy antiserum. this double staining, where the first staining is silver-gold intensified, was detectable at both light a ... | 1988 | 2901738 |
| changes in the metabolic profile of the equine gluteus medius as a function of sampling depth. | 1. cross sections from the middle of the gluteus medius were removed from 10 adult horses and used to evaluate changes in histochemically determined muscle fiber type and biochemically determined metabolic enzyme activities as a function of sample depth. 2. muscle fiber types determined using histochemical methods for myosin atpase (ph 9.4) and succinic dehydrogenase (sdh) activity indicated percent fast-twitch glycolytic (fg) muscle fibers decreased and slow-twitch oxidative (so) fibers increas ... | 1988 | 2907449 |
| eukaryote membrane genetics: the fo sector of mitochondrial atp synthase. | 1988 | 2907692 | |
| the androgenicity of progestational agents. | androgenic potency of the progestational component in oral contraceptives (ocs) is difficult to assess. all the 19-nor testosterone progestogens in oc formulations basically have similar potencies and androgenic activities with the exception of norgestrel (ng). ng is the most potent and androgenic of these agents. it is five to ten times as potent as norethindrone (net); levonorgestrel (1-ng), one of the two isomers of ng and the one responsible for its potency, is ten to 20 times more potent th ... | 2009 | 2908040 |
| an experimental study of susceptibility to infection after hemorrhagic shock. | hemorrhagic shock has been associated with an increased risk of infection after injury. the immediate and long term effects of hemorrhagic shock without tissue injury on the susceptibility of an animal to infection and the efficacy of antibiotic prophylaxis to prevent infection in this setting were examined. sprague-dawley rats were subjected to hemorrhagic shock (ld15) by bleeding to a mean arterial pressure of 45 millimeters of mercury for 45 minutes and were resuscitated with shed blood and n ... | 1989 | 2911791 |
| clinical and radiologic features of lacunar versus nonlacunar minor stroke. | we determined the angiographic presence of extracerebral and intracerebral arterial disease in 122 patients with minor stroke within the carotid territory; we excluded patients with a recognized cardiac source of emboli. based on clinical features and computed tomographic findings, patients were classified as having lacunar infarcts (n = 61), nonlacunar infarcts (n = 53), and infarcts of indeterminate type (n = 8). severe carotid bifurcation disease (greater than or equal to 50% stenosis or occl ... | 2010 | 2911836 |
| the craniofacial morphology in persons with maxillonasal dysplasia (binder syndrome). a longitudinal cephalometric study of orthodontically treated children. | the aim of this investigation was to study the influence of orthodontic treatment on facial growth in subjects with maxillonasal dysplasia. the subjects were followed longitudinally from early childhood until growth was completed or almost completed. fifteen patients, 9 boys and 6 girls, were orthodontically treated by conventional methods. they were compared with (1) another longitudinal group consisting of 13 orthodontically untreated children, 7 boys and 6 girls with the same syndrome, and (2 ... | 2010 | 2916471 |
| human milk feeding enhances the urinary excretion of immunologic factors in low birth weight infants. | the effects of fortified human milk feedings on the urinary excretion of lactoferrin, lysozyme, secretory component, iga, and secretory iga antibodies to escherichia coli o antigens were investigated in very low birth wt infants. infants were maintained on either a human milk or a cow's milk preparation. the amounts of each immune factor that were ingested and excreted were quantified during balance studies conducted at 2.5 and 5 wk of age. serum levels of these immune factors were similar in bo ... | 1989 | 2919134 |
| [medical journals and editorial freedom]. | 2009 | 2919151 | |
| degradation of type ix collagen by matrix metalloproteinase 3 (stromelysin) from human rheumatoid synovial cells. | the degradation of type ix collagen, a minor collagen in cartilage, was examined by treatment with three different types of matrix metalloproteinases (mmps) purified from the culture medium of rheumatoid synovial cells. neither mmp-1 (collagenase) nor mmp-2 (so-called 'gelatinase') could digest type ix collagen, but mmp-3 (stromelysin) readily degraded it into smaller fragments. this suggests that mmp-3 may be responsible for the pathological degradation and/or normal turnover of type ix collage ... | 1989 | 2920840 |
| vibrio vulnificus corneal ulcer. case reports. | 1989 | 2923553 | |
| nh2-terminal amino acid sequence analysis of qa-2 alloantigens. | 2010 | 2925232 | |
| [bone marrow necrosis. apropos of 2 cases]. | 2007 | 2933830 | |
| [how to prevent the tumor lysis syndrome]. | 2010 | 2935797 | |
| [an experience with combined procurement of the liver and kidneys for transplantation by a british team (cambridge)]. | 2010 | 2935806 | |
| dose-related effects of synthetic human beta-endorphin and naloxone on fed gastrointestinal motility. | in humans, plasma beta-endorphin levels rise during application of acute stressful stimuli (vertigo, cold pain, and transcutaneous electrical stimulation) that induce gut motor disturbances. whereas it is possible that circulating beta-endorphin participates in the mediation of these central effects on gut motility, its role cannot be established solely on the basis of changes in plasma levels. therefore, we designed the present study to investigate 1) the dose-related effects of intravenous syn ... | 1986 | 2942039 |
| structure-activity relationships of sex steroid analogs determined in vitro in a thyroid hormone-responsive membrane ca2+-atpase model. | physiological concentrations of l-t4 were found previously to stimulate ca2+-atpase activity in vitro in reticulocyte membranes from female rabbits and to inhibit this enzyme in reticulocyte membranes from males. in these previous studies, preincubation of intact cells or ghosts with testosterone (5 x 10(-11) m) converted female-source reticulocyte membranes to male-type responsiveness to thyroid hormone (inhibition of ca2+-atpase activity). preincubation of reticulocyte membranes with 17 beta-e ... | 1986 | 2946570 |
| structure-activity relationships of sex steroid analogs determined in vitro in a thyroid hormone-responsive membrane ca2+-atpase model. | physiological concentrations of l-t4 were found previously to stimulate ca2+-atpase activity in vitro in reticulocyte membranes from female rabbits and to inhibit this enzyme in reticulocyte membranes from males. in these previous studies, preincubation of intact cells or ghosts with testosterone (5 x 10(-11) m) converted female-source reticulocyte membranes to male-type responsiveness to thyroid hormone (inhibition of ca2+-atpase activity). preincubation of reticulocyte membranes with 17 beta-e ... | 1986 | 2946570 |
| ultrastructural changes in the sarcoplasmic reticulum in acute myocardial ischemia. | we investigated the morphologic changes in the sarcoplasmic reticulum (sr) in acute myocardial ischemia, induced by occlusion of the coronary artery in the canine heart, by freeze-fracture of sr in situ and in vitro, and they were compared to the alterations in ca++-stimulated atpase activity and protein composition of the isolated sr. both sr in situ and the isolated sr exhibited typical intramembranous particles with diameters of 70 to 90 a in freeze-fracture replicas. the intramembranous part ... | 1986 | 2948034 |
| treatment of mooren's ulcer with cyclosporin a: report of three cases. | three patients with severe, bilateral, progressive mooren's ulcers, unresponsive to medical and surgical therapy, were treated with cyclosporin a. all three responded rapidly to the drug and there has been no recurrence of the mooren's ulcers since (average follow-up 14 months). peripheral blood t lymphocyte subsets were estimated prior to and during treatment. no significant abnormalities were found initially. suppressor cells increased on treatment, and a corresponding drop of the helper/suppr ... | 2010 | 2949775 |
| reflex sympathetic dystrophy following nail biopsy. | reflex sympathetic dystrophy following a nail unit biopsy in a patient with long-standing, mycologically negative onychomycosis is reported. the significance of this complication is discussed, and the literature on the condition itself is reviewed. it is suggested that although adverse effects occur as a result of nail biopsy, they are infrequent and therefore should not dissuade the clinician from performing the procedure. biopsy is necessary in order to establish a more accurate diagnosis of n ... | 2010 | 2950143 |
| the effect of six months continuous subcutaneous insulin infusion on kidney function and size in insulin-dependent diabetics. | glomerular filtration rate (gfr), renal plasma flow (rpf), kidney volume, and urinary albumin excretion rate were measured in 24 insulin-dependent diabetics, aged 29 +/- 7 years (mean +/- s.d.) of 8 +/- 4 years duration, randomly allocated to either continuous subcutaneous insulin infusion (csii) (n = 12) or unchanged conventional insulin treatment (cit) (n = 12). glomerular filtration rate, renal plasma flow, and kidney volume were identical in the two groups at the start of the study, although ... | 2009 | 2951131 |
| differential effects of serotonin (5-ht1a and 5-ht2) agonists and antagonists on renin and corticosterone secretion. | the present study was designed to investigate the effect of distinct serotonin (5-ht1a and 5-ht2) agonists and antagonists on renin and corticosterone secretion. low doses of the selective 5-ht1a agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) (5.0-500.0 micrograms/kg, i.p.) and ipsapirone (tvx q 7821; 0.5-2.5 mg/kg, i.p.), and of the 5-hydroxytryptamine (5-ht) agonist mk-212 (2.0 mg/kg, i.p.), did not elevate plasma renin activity (pra) and concentration (prc) 30 min postinjection. ... | 1987 | 2952898 |
| differential effects of serotonin (5-ht1a and 5-ht2) agonists and antagonists on renin and corticosterone secretion. | the present study was designed to investigate the effect of distinct serotonin (5-ht1a and 5-ht2) agonists and antagonists on renin and corticosterone secretion. low doses of the selective 5-ht1a agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) (5.0-500.0 micrograms/kg, i.p.) and ipsapirone (tvx q 7821; 0.5-2.5 mg/kg, i.p.), and of the 5-hydroxytryptamine (5-ht) agonist mk-212 (2.0 mg/kg, i.p.), did not elevate plasma renin activity (pra) and concentration (prc) 30 min postinjection. ... | 1987 | 2952898 |
| regeneration and repair of periodontal tissues. | 2010 | 2955107 | |
| experimental echinococcus granulosus infection in mice: immunocytochemical analysis of lymphocyte populations in local lymphoid infections during early infection. | the influence of subcutaneous infection with protoscoleces of echinococcus granulosus on the distribution of lymphocyte subsets in draining lymph nodes has been evaluated by immunocytochemical labelling of lymphocyte surface antigens. these studies reveal marked expansion of paracortical thy-1+, lyt-1+ cells and moderate proliferation of surface immunoglobulin-bearing b-cells immediately after infection. the lyt-1+:lyt-2+ ratio decreases rapidly during the first 21 days post-infection and remain ... | 1987 | 2956563 |
| a multicentre open clinical trial of teicoplanin in infections caused by gram-positive bacteria. | a multicentre open trial of teicoplanin in 81 centres in nine european countries included 1431 cases: 531 female, 900 male; mean age 49.4 years, range 1-93 years. these were hospitalized patients most of whom had infections caused by staphylococcus aureus (816 isolates). of a total of 1427 gram-positive pathogens 280 (19.6%) were methicillin resistant. there were 536 skin and soft tissue infections, 263 septicaemias, 135 lower respiratory tract infections, 179 joint and bone infections and 83 en ... | 1988 | 2965133 |
| activation of a cytosolic serine protein kinase by epidermal growth factor. | exposure of a-431 cells to epidermal growth factor (egf) results in a rapid enhancement (approximately 10-fold) of cytosolic serine protein kinase activity. the increase in serine kinase activity may be detected using a number of peptide and protein substrates. enhancement of kinase activity occurs within 1 min of exposure of the cells to egf and reaches a maximum in 5 min. similar results were obtained with a variety of cell lines. we have partially purified the egf-activated kinase from a-431 ... | 2010 | 2974035 |
| cns-induced natriuresis during dopamine receptor blockade. further support for the existence of, at least, two separate natriuretic hormonal systems. | intracerebroventricular (icv) stimulation with hypertonic sodium chloride solutions has previously shown indications to stimulate the release of a blood-borne natriuretic factor. sodium excretion in this situation increases in the order of 10-20 times. acute isotonic volume expansion has shown to be a potent stimulus for endogenous release of the atrial natriuretic factor (anf). it has also been demonstrated that the natriuretic response to both volume expansion and exogenously applied anf can b ... | 1988 | 2976234 |
| restriction nuclease digestions driven to completion by escherichia coli rna polymerase and t4 gene 32 protein. | restriction enzyme digestions of large scale dna preparations often do not go to completion. this is due to product inhibition by the newly generated ends of the digested dna. the addition of exogenous proteins that bind tightly to the free ends of dna or to single-stranded dna will relieve this inhibition. we show that a considerable savings on restriction nucleases can be attained by the addition of rna polymerase or t4 gene 32 protein in stoichiometric amounts to the newly produced dna ends. | 1985 | 2981211 |
| herpes simplex virus and cytomegalovirus infections in burned patients. | herpesvirus infections are commonly seen in immunosuppressed patients and may account for considerable morbidity and some mortality. we prospectively studied 52 patients with severe burn injuries in order to determine the prevalence of viral infections in this group of patients. serologic testing was done each week to diagnose primary and reactivation infections. twenty-seven of 52 patients (52%) became infected with either herpes simplex virus (hsv) or cytomegalovirus (cmv) or both. hsv infecti ... | 1985 | 2981325 |
| conditioned taste aversion suppresses induction of delayed-type hypersensitivity immune reactions. | conditioned taste aversion was induced in mice by pairing saccharin drinking with an intraperitoneal injection of lithium chloride, a toxic but nonimmunosuppressive drug. conditioned mice showed not only suppressed saccharin drinking but also a 75% reduction in the induction of delayed-type hypersensitivity immune responses to low doses of sheep erythrocytes. this effect was observed with doses of lithium chloride which had no effect of their own on immune functions. in addition, a reduction in ... | 1985 | 2987987 |
| inflammatory myopathies: part 2. | 1985 | 2988409 | |
| receptors for epidermal growth factor in the rat uterus. | uterine membranes contain high affinity [dissociation constant (kd) = 0.36 nm], saturable binding sites for [125i]iodo-epidermal growth factor (egf). the binding of [125i] iodo-egf is specific since it is abolished by excess unlabeled egf but not by excess unlabeled insulin, fibroblast growth factor, or multiplication-stimulating activity. incubation of [125i] iodo-egf with uterine membranes, followed by chemical cross-linking with disuccinimidyl suberate and detergent extraction reveals a major ... | 1985 | 2988913 |
| the biologic significance of the mixed lymphocyte kidney culture in humans. | the mixed lymphocyte kidney culture (mlkc) in humans has been studied in normal and abnormal clinical conditions. human renal cortical cells were extracted by collagenase treatment from the kidneys of "normal" heart-beating cadaver organ donors (n = 13), patients with end-stage renal disease (esrd) at pretransplant bilateral nephrectomy and splenectomy (n = 13), and from irreversibly rejected renal allografts at the time of graft nephrectomy (n = 5). proliferation of peripheral blood t lymphocyt ... | 1985 | 2996186 |
| [surgery in the treatment of patients with small cell lung cancer]. | the data on surgical and combined treatment of 52 cases of small cell lung cancer are presented and the end results are evaluated. the findings on survival time make the case for surgery as a component of combined treatment of tumor. the best results were obtained in cases of stage i and ii tumor, absence of metastases into intrathoracic lymph nodes, tumor invasion limited to bronchopulmonary lymph nodes or the root of the lung, intermediate cell pattern of small cell lung cancer and surgery fol ... | 2010 | 2998088 |
| evaluation of a photolabile derivative of 1,25-dihydroxyvitamin d3 as a photoaffinity probe for 1,25-dihydroxyvitamin-d3 receptor in chick intestinal cytosol. | we evaluated the viability of 1 alpha, 25-dihydroxyvitamin d3-3 beta-[n-(4-azido-2-nitrophenyl)glycinate] (1,25-(oh)2-d3-ang), an analog of 1 alpha, 25-dihydroxyvitamin d3 (1,25-(oh)2-d3) as a photoaffinity probe for 1,25-(oh)2-d3 receptor in chick intestinal cytosol. a competitive-binding assay revealed that chick intestinal cytosolic 1,25-(oh)2- d3 receptor bound to 1,25-(oh)2-d3-ang approximately 20-times less effectively than it did to 1,25-(oh)2-d3. irradiation of 1,25-(oh)2-d3- ang in the ... | 1985 | 2998355 |
| effect of pyrimidinone treatment on lethal and immunosuppressive murine cytomegalovirus infection. | the 2-amino-5-halo-pyrimidinones, which are potent interferon inducers and antiviral agents, were found to be protective against lethal cytomegalovirus (cmv) challenge in weanling or neonatal mice when administered before virus challenge. this protection was dependent upon the dosage of pyrimidinone administered. weanling mice infected with a sublethal challenge of cmv exhibited moderate to severe immunosuppression as measured by reduced splenic cell blastogenic responses in vitro to the mitogen ... | 1985 | 3000290 |
| dimethylthiourea consumption reflects h2o2 concentrations and severity of acute lung injury. | even though dimethylthiourea (dmtu) effectively scavenges o2 metabolites in vitro, it is often unclear if scavenging of o2 metabolites is the mechanism by which dmtu decreases tissue injury in biological models. since dmtu not only scavenges o2 metabolites but is also consumed in a dose-response manner following reaction with hydrogen peroxide (h2o2) in vitro, we wondered whether dmtu would also be consumed by o2 metabolites in biological systems and if dmtu consumption would then reflect o2 met ... | 1985 | 3001019 |
| [unusual computed tomographic findings following shunting of hydrocephalus internus permagnus]. | 2010 | 3008264 | |
| the cellular immune response in thermal injured patients. | 2010 | 3008532 | |
| extragonadal retroperitoneal germ cell tumors without apparent testicular involvement. a search for the source. | extratesticular germ cell neoplasms without apparent testicular primary tumors are rare. the origin of these neoplasms has been debated in the literature for decades. with the advent of effective chemotherapy for extratesticular germ cell neoplasms, the origin of these tumors becomes more than academic. we report on 3 cases of retroperitoneal germ cell neoplasms with microscopic intratesticular primary tumors. all patients with extragonadal germinal cell tumors of the testes should undergo thoro ... | 2010 | 3012846 |
| extragonadal retroperitoneal germ cell tumors without apparent testicular involvement. a search for the source. | extratesticular germ cell neoplasms without apparent testicular primary tumors are rare. the origin of these neoplasms has been debated in the literature for decades. with the advent of effective chemotherapy for extratesticular germ cell neoplasms, the origin of these tumors becomes more than academic. we report on 3 cases of retroperitoneal germ cell neoplasms with microscopic intratesticular primary tumors. all patients with extragonadal germinal cell tumors of the testes should undergo thoro ... | 2010 | 3012846 |
| the adenosine triphosphate-pyrophosphate isotopic exchange reaction: a tool for determination of tryptophan. | quantitative determination of tryptophan at the picomole level is described, using the atp-[32p]ppi isotopic exchange reaction catalyzed by tryptophanyl-trna synthetase. sensitivity limits of 500 fmol were obtained. the presence of other amino acids at a 1000-fold excess over tryptophan did not interfere significantly with the quantitative determination of tryptophan. the specificity of the reaction was checked using five tryptophan analogs. these analogs did not prevent the determination of try ... | 2010 | 3014918 |
| susceptibility to varicella-zoster virus among adults at high risk for exposure. | the adult health care provider who is susceptible to varicella zoster virus (vzv) represents a risk to her or himself and to patients. nineteen percent of employees at this children's hospital had no or uncertain prior experience with vzv, and of these, 28% were found to be vzv susceptible, representing 5% of the total population of 2,730 hospital employees. during the 12 months of study, six of the potential 135 to 137 vzv-susceptible individuals acquired varicella. vzv-susceptible health care ... | 1986 | 3019915 |
| susceptibility to varicella-zoster virus among adults at high risk for exposure. | the adult health care provider who is susceptible to varicella zoster virus (vzv) represents a risk to her or himself and to patients. nineteen percent of employees at this children's hospital had no or uncertain prior experience with vzv, and of these, 28% were found to be vzv susceptible, representing 5% of the total population of 2,730 hospital employees. during the 12 months of study, six of the potential 135 to 137 vzv-susceptible individuals acquired varicella. vzv-susceptible health care ... | 1986 | 3019915 |
| carbachol- and norepinephrine-stimulated phosphoinositide metabolism in rat brain: effect of chronic cholinesterase inhibition. | activation of cholinergic muscarinic receptors leads to several biochemical events including an increased turnover of phosphoinositides. in this study we have investigated whether repeated administration of the organophosphorus insecticide disulfoton, known to cause the development of tolerance to this compound, would affect phosphoinositide metabolism in rat brain. basal and carbachol-stimulated phosphoinositide metabolism were measured in cerebral cortex slices, by measuring the accumulation o ... | 1986 | 3020234 |
| carbachol- and norepinephrine-stimulated phosphoinositide metabolism in rat brain: effect of chronic cholinesterase inhibition. | activation of cholinergic muscarinic receptors leads to several biochemical events including an increased turnover of phosphoinositides. in this study we have investigated whether repeated administration of the organophosphorus insecticide disulfoton, known to cause the development of tolerance to this compound, would affect phosphoinositide metabolism in rat brain. basal and carbachol-stimulated phosphoinositide metabolism were measured in cerebral cortex slices, by measuring the accumulation o ... | 1986 | 3020234 |
| mapping of the class ii region of the human major histocompatibility complex by pulsed-field gel electrophoresis. | the class ii region of the human major histocompatibility complex (mhc) encodes a polymorphic set of cell surface glycoproteins involved in the regulation of the immune response. each glycoprotein is a heterodimer composed of a alpha-chain of relative molecular mass (mr) 34,000 (34 k) and a beta-chain of mr = 28k. the products of the class ii region have been characterized by the mixed lymphocyte reaction, serology, primed lymphocyte typing and dna cloning. dr, dq and dp, three subregions contai ... | 1986 | 3020430 |
| mapping of the class ii region of the human major histocompatibility complex by pulsed-field gel electrophoresis. | the class ii region of the human major histocompatibility complex (mhc) encodes a polymorphic set of cell surface glycoproteins involved in the regulation of the immune response. each glycoprotein is a heterodimer composed of a alpha-chain of relative molecular mass (mr) 34,000 (34 k) and a beta-chain of mr = 28k. the products of the class ii region have been characterized by the mixed lymphocyte reaction, serology, primed lymphocyte typing and dna cloning. dr, dq and dp, three subregions contai ... | 1986 | 3020430 |
| [kinin aminopeptidase in lung tissue and activity of kininase ii in the serum of patients with silicosis]. | 2010 | 3020528 | |
| [kinin aminopeptidase in lung tissue and activity of kininase ii in the serum of patients with silicosis]. | 2010 | 3020528 | |
| production of platelet-derived growth factor-like molecules by cultured arterial smooth muscle cells accompanies proliferation after arterial injury. | the migration and proliferation of smooth muscle cells (smcs) within the intima of arteries following mechanical injury is thought to be initiated by vessel wall injury and release of growth factors, in particular the platelet-derived growth factor (pdgf). however, the mechanism by which smc proliferation is regulated after platelet interaction with the vessel wall has ceased is unknown. here we show that smcs derived from the intima of injured rat arteries (intimal smcs) are phenotypically dist ... | 1986 | 3020543 |
| production of platelet-derived growth factor-like molecules by cultured arterial smooth muscle cells accompanies proliferation after arterial injury. | the migration and proliferation of smooth muscle cells (smcs) within the intima of arteries following mechanical injury is thought to be initiated by vessel wall injury and release of growth factors, in particular the platelet-derived growth factor (pdgf). however, the mechanism by which smc proliferation is regulated after platelet interaction with the vessel wall has ceased is unknown. here we show that smcs derived from the intima of injured rat arteries (intimal smcs) are phenotypically dist ... | 1986 | 3020543 |
| evidence that a human soluble beta-galactoside-binding lectin is encoded by a family of genes. | two cdna clones were isolated by immunoscreening a human hepatoma cdna library with an antiserum that bound specifically to a human soluble beta-galactoside-binding lectin with mr of approximately 14,000. the deduced amino acid sequences of the inserts of these two clones show considerable homology with each other, the sequence of chicken skin beta-galactoside-binding lectin, and eight peptides derived from purified human lung lectin of mr approximately 14,000. however, the sequence differences ... | 1986 | 3020551 |
| evidence that a human soluble beta-galactoside-binding lectin is encoded by a family of genes. | two cdna clones were isolated by immunoscreening a human hepatoma cdna library with an antiserum that bound specifically to a human soluble beta-galactoside-binding lectin with mr of approximately 14,000. the deduced amino acid sequences of the inserts of these two clones show considerable homology with each other, the sequence of chicken skin beta-galactoside-binding lectin, and eight peptides derived from purified human lung lectin of mr approximately 14,000. however, the sequence differences ... | 1986 | 3020551 |
| exposure of sheep to natural aerosols of foot-and-mouth disease virus. | sheep taken individually and allowed to inhale air being drawn along a duct from a cabinet containing pigs acutely infected with foot-and-mouth disease virus for 10 or 15 minute periods were infected by doses as low as 10 tcid50 of virus. the most consistent and reliable indicators of infection were viraemia and seroconversion. the mean times from exposure to onset of viraemia, pyrexia and the appearance of vesicular lesions were 2.5, 3.8 and 4.7 days, respectively. neither the time from exposur ... | 1986 | 3020658 |
| [structure and functions of cloned adenovirus dna]. | 1986 | 3020801 | |
| subtypes and functions of alpha-adrenoceptors. | 1986 | 3020944 | |
| thymidine kinase with altered substrate specificity of acyclovir resistant varicella-zoster virus. | the acyclovir resistant mutant of varicella-zoster virus acv-r (a 8) induced the same level of thymidine kinase activity in infected cells as the parent kawaguchi strain. however, it induced less deoxycytidine kinase activity and did not induce phosphorylating activity for the nucleotide analogue, 9-(2 hydroxy-ethoxymethyl)-guanine-(acyclovir). another acyclovir resistant mutant, acv-r (a 4), which is cross-resistant to phosphonoacetate and is thought to be a viral dna polymerase mutant, induced ... | 1986 | 3022711 |
| identification and characterization of mg2+-dependent phosphotyrosyl protein phosphatase from rat liver cytosol. | although highly purified preparations of mg2+-dependent phosphoseryl protein phosphatase (also designated phosphatase ia or phosphatase 2c) dephosphorylated phosphotyrosyl histone, the activity has been resolved from phosphatase ia by polyacrylamide gel electrophoresis at ph 9.5. this novel phosphotyrosyl-specific protein phosphatase absolutely requires mg2+ or mn2+ for activity, is inhibited by zn2+, vanadate and fluoride, and has an optimal ph of 9.0 and mr = 50,000. certain properties of this ... | 1986 | 3022716 |
| [histological confirmation of monostotic paget's disease in the sacrum by ct-guided bone puncture biopsy]. | 2011 | 3024265 | |
| the chicken carbonic anhydrase ii gene: evidence for a recent shift in intron position. | the complete nucleotide sequence of the coding region of the chicken carbonic anhydrase ii (ca ii) gene has been determined from clones isolated from a chicken genomic library. the sequence of a nearly full length chicken ca ii cdna clone has also been obtained. the gene is approximately 17 kilobase pairs (kb) in size and codes for a protein that is comprised of 259 amino acid residues. the 5' flanking region contains consensus sequences commonly associated with eucaryotic genes transcribed by r ... | 1987 | 3029691 |
| membrane phospholipids alter nutrient transport and drug toxicity in tumorigenic fibroblasts. | the phospholipid polar head group composition of lm cell plasma membranes was nutritionally altered by choline analogue supplementation. phosphatidylcholine (pc), normally 60% of total phospholipid, was depleted by 60 to 90% in membranes from cells cultured with n, n'-dimethylethanolamine (dme), n-monomethylethanolamine (me), and ethanolamine (e). enrichment of lm cell membranes with choline analogues, such as dme-, me-, and e-containing phospholipids, decreased the transport of [3h]thymidine, [ ... | 2011 | 3032553 |
| role of postnatal gonadal function in the determination of thyrotropin (tsh) releasing hormone-induced tsh response in adult male and female rats. | permanent effects of postnatal gonadal function on the hypothalamo-pituitary-thyroid axis were examined in male and female rats of the wistar-imamichi strain. animals were used at the age of about 10 weeks. neonatally castrated (nc) males showed a significantly higher plasma tsh response to trh (10 micrograms/kg bw, ip) than males castrated at 1, 2, 3, 4, or 6 weeks of age. the tsh response in intact males was similar to that seen in nc males. neonatal androgenization of nc males with 100 microg ... | 1987 | 3032567 |
| effects of inhibitors of the cytoplasmic structures and functions on the early phase of infection of cultured cells with simian virus 40. | to obtain information about cytoplasmic structures and functions involving the entry of simian virus 40 virions into cells, we examined whether the inhibitors that affect the functions and/or structure of lysosomes, cell membrane, and cytoskeletons inhibit expression of nuclear t antigen in the sv40-inoculated rat 3y1 and monkey cv-1 cells. chloroquine, methylamine, and butylamine did not inhibit t-antigen expression, suggesting that lysosomal acidification is not required for establishment of i ... | 1987 | 3033894 |
| maturation antigen of the mouse sperm flagellum: ii. origin from holocrine cells of the distal caput epididymis. | during epididymal transit, the mouse sperm flagellum acquires a surface glycoprotein (sma4) from epididymal fluid that functions as a sperm antiagglutinin. to determine the origin of this molecule, testes and epididymides of male mice were sectioned for light microscopy and stained with wheat germ agglutinin (wga)-peroxidase, a probe that has been used previously to examine the biology of sma4. wga reactivity was localized to the cytoplasm in a small population of cells in the distal caput epidi ... | 1987 | 3034104 |
| calmodulin-mediated cadmium inhibition of phosphodiesterase activity, in vitro. | ion-stripped bovine brain calmodulin (cam) binds 4 moles cd2+ as well as 4 moles ca2+ per mole protein, with similar affinity; in the presence of 1 mm mg2+ the molar binding ratio of cam for ca2+ decreased to 3, the apparent k0.5 for ca2+ nearly doubled, but the binding characteristics of cam for cd2+ were not changed. saturating concentrations ca2+ did not affect the molar binding ratio of cam for cd2+, but increased the apparent k0.5 for cd2+; vice versa, saturating concentrations cd2+ decreas ... | 1987 | 3034196 |
| radiation-induced dna damage and its repair. | application of modern methods of organic chemistry and recombinant dna technologies has provided new insights in the field of dna radiation damage and its repair. an overview of the chemical nature of the lesions inflicted on dna by ionizing radiation is presented. the structures of 29 different dna modified base or sugar residues are shown in comprehensive formation schemes. a fraction of radiation-induced modified bases is spontaneously released from the dna chain during irradiation. another p ... | 1987 | 3034813 |
| radiation-induced dna damage and its repair. | application of modern methods of organic chemistry and recombinant dna technologies has provided new insights in the field of dna radiation damage and its repair. an overview of the chemical nature of the lesions inflicted on dna by ionizing radiation is presented. the structures of 29 different dna modified base or sugar residues are shown in comprehensive formation schemes. a fraction of radiation-induced modified bases is spontaneously released from the dna chain during irradiation. another p ... | 1987 | 3034813 |
| cyclophosphamide in chronic progressive multiple sclerosis. | 2010 | 3037447 | |
| cyclophosphamide in chronic progressive multiple sclerosis. | 2010 | 3037447 | |
| characterization of two types of histone h2b genes from macronuclei of tetrahymena thermophila. | two histone h2b gene clones were isolated from macronuclei of tetrahymena thermophila. nucleotide sequences of the two clones were highly homologous within the coding region but not in the noncoding region. comparison of the deduced amino acid sequences between the two clones showed three differences in a total of 121 amino acids. each of the two clones contained a taa triplet within the coding region, which appeared to code for a glutamine residue. to demonstrate the existence of histone mrna c ... | 2010 | 3039463 |
| identification of free radicals in myocardial ischemia/reperfusion by spin trapping with nitrone dmpo. | the spin trapping esr technique was applied to investigate oxygen-derived radicals in ischemic and post-ischemic rat hearts. using 5,5'-dimethyl-l-pyrroline-n-oxide, carbon-centered radicals were identified during ischemia and oxy-radical adducts (superoxide anion radical, o.-2 and hydroxyl radicals, .oh) in post-ischemic rat heart. the formation of these spin adducts was inhibited by superoxide dismutase, suggesting that superoxide plays a role in the adducts' formation. the results demonstrate ... | 1987 | 3040465 |
| examination of cardiac alpha-adrenoceptors from pharmacological responses and radioligand binding. comparison of rat and guinea pig tissues. | the object of this study was to determine suitable experimental conditions for the pharmacological evaluation of cardiac alpha-adrenoceptors. atrial and ventricular preparations of the guinea pig and rat were employed, and the alpha-adrenoceptor responsiveness was compared with the binding of the alpha-adrenoceptor radioligand [3h]prazosin in membranes prepared from these cardiac regions. the experimental variables examined were the pacing frequency, bath temperature, choice of agonist, and card ... | 1987 | 3041119 |
| pemphigoid-like bullous eruption related to ibuprofen. | we report two patients who had a bullous eruption limited to the lower extremities when first seen by us. clinically the eruption resembled limited bullous pemphigoid. in both patients the onset of the eruption was associated with ibuprofen therapy, and lesions promptly resolved after discontinuing the ibuprofen. this type of presentation has not been reported previously as an adverse effect of ibuprofen. bullous reactions to nonsteroidal anti-inflammatory agents are briefly reviewed. | 2011 | 3042819 |
| [x-ray computed tomography in venous pathology]. | after presenting the tomodensitometric semiology of venous thromboses in various territories, the authors define its indications. it is essentially in deep territories, head, chest and abdomen that the ct-scan is used to study and diagnose unrecognized thromboses as well as determine the venous repercussion of various neighboring ailments. the respective place of the ct-scan, ultrasonography and various phlebographies is analyzed. | 2011 | 3043474 |
| the history of the use of vacuum extraction. | 2010 | 3047531 | |
| [a multi-factorial approach in the vital prognosis of spontaneous intracerebral hematoma]. | the prognostic assessment of a patient with intra-cerebral hemorrhage (ih) requires simultaneous appraisal of several parameters. we have attempted this with a multivariate method: discriminant analysis. we studied retrospectively 142 patients with non-operated ih, not due to vascular malformation, distributed two months after the initial event in two groups: 92 living patients and 50 dead. discriminant analysis of 21 parameters from the initial examination and ct scan, selected five factors whi ... | 2010 | 3047834 |
| bimaxillary proclination in patients of afro-caribbean origin. | the facial morphology of the afro-caribbean negro is reviewed and the aims of treatment for bimaxillary proclination and its subsequent stability are discussed. treatment approaches to various clinical situations are described, together with their known limitations. | 2011 | 3048380 |
| racism, the national health service, and the health of black people. | racism has been and is central to an understanding of the health of black people in britain. black people have played and are playing a central role in the national health service (nhs). their role is, however, shaped by racism. their experiences as consumers of the nhs are also shaped by racism--in terms of their treatment for both physical and mental health problems. in addition, their specific health problems such as sickle cell anemia have not received the attention they deserve. the nhs has ... | 2011 | 3049409 |
| some extra-articular manifestations of arthritis and complications of therapy. a pictorial essay. | more than 100 years ago lasegue wrote, "rheumatic fever licks at the joint but bites at the heart." this truth may be expanded to include nearly every joint ailment on one hand, and nearly every organ system on the other hand. in connective tissue disorders, bleeding diasthesias and metabolic and endocrine disorders, the joint manifestations are only one part of the total picture. this article shows a few examples of cardiopulmonary, gastrointestinal, and other manifestations. a few examples of ... | 2011 | 3051097 |
| a mutant human proinsulin is secreted from islets of langerhans in increased amounts via an unregulated pathway. | a coding mutation in the human insulin gene (his-b10----asp) is associated with familial hyperproinsulinemia. to model this syndrome, we have produced transgenic mice that express high levels of the mutant prohormone in their islets of langerhans. strain 24-6 mice, containing about 100 copies of the mutant gene, were normoglycemic but had marked increases of serum human proinsulin immunoreactive components. biosynthetic studies on isolated islets revealed that approximately 65% of the proinsulin ... | 1988 | 3057496 |
| a mutant human proinsulin is secreted from islets of langerhans in increased amounts via an unregulated pathway. | a coding mutation in the human insulin gene (his-b10----asp) is associated with familial hyperproinsulinemia. to model this syndrome, we have produced transgenic mice that express high levels of the mutant prohormone in their islets of langerhans. strain 24-6 mice, containing about 100 copies of the mutant gene, were normoglycemic but had marked increases of serum human proinsulin immunoreactive components. biosynthetic studies on isolated islets revealed that approximately 65% of the proinsulin ... | 1988 | 3057496 |
| probable detection of kil peptide derived from colicin e1 plasmid in the envelope fraction of escherichia coli hb101 carrying peap31. | escherichia coli carrying plasmid peap31 produces extracellularly alkalophilic bacillus penicillinase encoded on the plasmid. the extracellular production has been suggested to be caused by activation of dormant colicin e1 kil gene. two peptides that could be respectively precursor and mature products of colicin e1 kil gene were detected on an sds/polyacrylamide gel. one of the peptides (mr 4800), which was probably a precursor peptide, was detected in the inner-membrane fraction from the organi ... | 1988 | 3058121 |
| probable detection of kil peptide derived from colicin e1 plasmid in the envelope fraction of escherichia coli hb101 carrying peap31. | escherichia coli carrying plasmid peap31 produces extracellularly alkalophilic bacillus penicillinase encoded on the plasmid. the extracellular production has been suggested to be caused by activation of dormant colicin e1 kil gene. two peptides that could be respectively precursor and mature products of colicin e1 kil gene were detected on an sds/polyacrylamide gel. one of the peptides (mr 4800), which was probably a precursor peptide, was detected in the inner-membrane fraction from the organi ... | 1988 | 3058121 |
| high-molecular-weight neutral proteinase of rat ascites hepatoma cells and their collagenolytic activity. | a high-molecular-weight proteinase in rat ascites hepatoma ah109a cells was purified to apparent homogeneity by conventional chromatographic techniques. the purified proteinase degraded over the broad ph range, 7.0-9.0, not only denatured hemoglobin but also type i and iv collagen in the absence of calcium. its activity was maximum at ph 8.0, heat-labile and affected by thiol reagents. serine proteinase inhibitors such as diisopropyl fluorophosphate, soybean trypsin inhibitor, leupeptin, and ant ... | 1988 | 3058624 |
| morbidity and mortality of carotid endarterectomy under local anesthesia: a retrospective study. | it has been shown that carotid endarterectomy reduces the incidence of stroke in patients with symptomatic extracranial occlusive vascular disease in the absence of major perioperative complications such as stroke or death. we present a retrospective study of 106 carotid endarterectomies performed under local anesthesia in 100 patients in whom transient ischemic attack (tia) or minor stroke had occurred. nonfatal stroke occurred in 2%, and tia occurred in 1%. there was no perioperative mortality ... | 2011 | 3059211 |
| vitamin e deficiency and neurologic disease. | during the recent resurgence of interest in the clinical uses of vitamin e, one of the major foci of attention has been the neurologic role of vitamin e in humans. studies in patients with secondary vitamin e deficiency, caused by fat malabsorption disorders and total parenteral nutrition lacking an adequate supply of vitamin e, have elucidated a clinical disorder and histologic lesions of the nervous system and muscle that closely resemble those of experimental vitamin-e-deficient animal models ... | 1988 | 3060170 |
| emphasis on preventive perinatology: a suitable alternative for developing countries. | the potential efficacy of preventive interventions in latin america to reduce perinatal morbidity and mortality is reviewed. the most important perinatal risk factors associated with pregnancy and delivery are young age of the mother, low socioeconomic status, low education, malnutrition, lack of prenatal care, pregnancy-induced-hypertension, perinatal infections, alcohol, smoking, and iatrogenic causes. adequate data are lacking to determine the magnitude of these factors in latin america. iatr ... | 2011 | 3065947 |
| [use of photosensitizing preparations in the treatment of cancer of the orl organs]. | 2011 | 3067440 | |
| what schedule-induced polydipsia can tell us about alcoholism. | an animal model of chronic and excessive voluntary (unforced) alcohol ingestion is presented in which, by drinking, animals produce repeated, substantial elevations in blood ethanol concentration and develop physical dependence. the overindulgence is elective in that ethanol is chosen in preference to certain other fluid-ingestive alternatives. beside the usual demonstrations of acutely compromised motor performance, tolerance development, cross-tolerance, etc., the model demonstrates that the c ... | 1988 | 3067598 |
| what schedule-induced polydipsia can tell us about alcoholism. | an animal model of chronic and excessive voluntary (unforced) alcohol ingestion is presented in which, by drinking, animals produce repeated, substantial elevations in blood ethanol concentration and develop physical dependence. the overindulgence is elective in that ethanol is chosen in preference to certain other fluid-ingestive alternatives. beside the usual demonstrations of acutely compromised motor performance, tolerance development, cross-tolerance, etc., the model demonstrates that the c ... | 1988 | 3067598 |
| captopril--a new approach for treatment of male subfertility? | 2011 | 3067628 | |
| [academic dissertations of military pharmacists on the history of pharmacy]. | 2011 | 3067684 | |
| a case of vibrio vulnificus infection. | vibrio vulnificus, a recently described strain of the halophilic vibrio species, was isolated from the blood of a 73-year-old man, who developed rapidly progressive wound infection and fatal septicemia. twenty-one patients with vibrio vulnificus infection have been reported in the japanese literature. vibrio vulnificus most frequently causes primary septicemia and necrotising cellulitis after the eating of raw fish or shellfish or after exposure to seawater. the infection is characterized by its ... | 1988 | 3068394 |
| role of the protease in the permeability enhancement by vibrio vulnificus. | the protease produced by vibrio vulnificus enhances vascular permeability through histamine release from mast cells and activation of the plasma kallikrein-kinin system which generates bradykinin when injected into the dorsal skin. v. vulnificus living cells also enhanced vascular permeability within a few hours after the injection into the dorsal skin. the permeability-enhancing activity of living cells was greatly reduced by addition of soybean trypsin inhibitor, a specific inhibitor for plasm ... | 1988 | 3068493 |
| [pharmacokinetic and toxicologic aspects of stress]. | 2011 | 3069119 | |
| subcutaneous bronchogenic cysts. | recent experience with a bronchogenic cyst occurring in a subcutaneous suprasternal location presents an additional entity to be considered in the differential diagnosis of head and neck lesions, and correlates with the embryology of the developing tracheobronchial tree and sternum. a review of subcutaneous bronchogenic cysts shows 41 cases have been described in the english literature. most were noted in the suprasternal location; all but one were first noted in infancy or childhood. there is a ... | 2011 | 3072402 |
| parasitic diarrhea. | this article reviews the biology, epidemiology, and clinical management of amebiasis, giardiasis, and cryptosporidiosis as well as the less common intestinal protozoa, dientamoeba fragilis, isospora belli, balantidium coli, and blastocystis hominis. | 1988 | 3074123 |