Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| clinical and endoscopic features in patients with hospital-acquired diarrhea associated with clostridium difficile infection. | clostridium difficile (cd) is the leading cause of hospital-acquired diarrhea. clinical and endoscopic findings are poorly described in our country. the aim of this study is to depict those findings. | 2017 | 28363494 |
| fluoroquinolone prophylaxis in autologous hematopoietic stem cell transplant recipients. | although fluoroquinolone prophylaxis is frequently utilized in autologous hematopoietic stem cell transplant (ahsct) patients, its impact on morbidity and mortality is uncertain. this study investigates the role of quinolone prophylaxis after ahsct in recent years. | 2017 | 28365897 |
| invasive listeriosis in a patient with several episodes of antibiotic associated colitis presumably due to clostridium difficile. | a 62-year-old man developed a blood stream infection and meningitis due to listeria monocytogenes, 20 days after an episode of pseudo-membranous colitis. the patient, hospitalized for the first time for transurethral prostatectomy, was readmitted 20 days later with watery diarrhea. pseudo-membranous colitis was diagnosed and treated successfully, without testing for clostridium difficile infection (cdi). after 15 more days, the patient developed again diarrhea, fever and confusion. hospitalized ... | 2017 | 28365900 |
| development of a dose assay for a clostridium difficile vaccine using a tandem ion exchange high performance liquid chromatography method. | clostridium difficile is a gram-positive intestine bacterium that causes a severe diarrhea and could eventually be lethal. the main virulence factor is related to the release of two major exotoxins, toxin a (tcda) and toxin b (tcdb). recent c. difficile-associated disease (cdad) outbreaks have been caused by hypervirulent strains which secrete an additional binary toxin (cdta/cdtb). vaccination against these toxins is considered the best way to combat the cdad. recently, a novel tetravalent c. d ... | 2017 | 28366569 |
| strongyloides stercoralis infection among human immunodeficiency virus (hiv)-infected patients in the united states of america: a case report and review of literature. | background strongyloides stercoralis infection is endemic in subtropical and tropical regions but is reported rather sporadically in temperate countries. in the usa, the highest rates of infection are from the southeastern states, predominantly among immigrants. there is paucity of case reports on s. stercoralis infection among hiv-infected patients who were born and raised in the usa. case report a 61-year-old male with known hiv infection (cd4 count: 235 cells/ul, undetectable hiv rna, on anti ... | 2017 | 28366929 |
| infection rates in tacrolimus versus cyclosporine-treated pediatric kidney transplant recipients on a rapid discontinuation of prednisone protocol: 1-year analysis. | ar is lower in pktx recipients on tac vs csa. data comparing infection outcomes for children treated with these agents are limited. we retrospectively studied infection outcomes in 96 pktx recipients on a rdp. ps, dcgs, ar, and infection-free survival were assessed using kaplan-meier/log-rank tests and proportional hazards models. there were no differences in 1-year ps, dcgs, or ar between tac and csa recipients. after adjusting for ar, the hazard of cmv viremia was 4.0 times higher (95%ci: 1.04 ... | 2017 | 28371243 |
| does electronic stewardship work? | faced with national requirements to promote antimicrobial stewardship and reduce drug-resistant infections, community hospitals are challenged to make the best use of existing resources. eighteen months after building antibiotic decision support into our electronic order platform, high-risk antibiotic use decreased by 83% (p < .001) at our community hospital. hospital-acquired clostridium difficile infections declined 24% (p = .07). | 2017 | 28371928 |
| microbiota. | the human microbiota comprises all the microorganisms of our body, which can also be categorised as commensals, mutualists and pathogens according to their behaviour. our knowledge of the human microbiota has considerably increased since the introduction of 16s rrna next generation sequencing (16s rdna gene). this technological breakthrough has seen a revolution in the knowledge of the microbiota composition and its implications in human health. this article details the different human bacterial ... | 2017 | 28372875 |
| the gut microbiome. | more than a trillion, mostly good, microbes live within our gastrointestinal tract and are responsible for vital metabolic, immune and nutritional functions. dysbiosis, meaning a maladaptive imbalance of the microbiome, is associated with many common diseases and is a target for therapy. | 2017 | 28376573 |
| use of a perianal swab compared with a stool sample to detect symptomatic clostridium difficile infection. | objective to evaluate the use of a perianal swab to detect cdi. methods a perianal swab was collected from each inpatient with a positive stool sample for c. difficile (by polymerase chain reaction [pcr] test) and was tested for c. difficile by pcr and by culture. the variables evaluated included demographics, cdi severity, bathing before perianal swab collection, hours between stool sample and perianal swab, cycle threshold (ct) to pcr positivity, and doses of cdi treatment before stool sample ... | 2017 | 28376944 |
| challenges and strategies for prevention of multidrug-resistant organism transmission in nursing homes. | nursing home residents are at high risk for colonization and infection with bacterial pathogens that are multidrug-resistant organisms (mdros). we discuss challenges and potential solutions to support implementing effective infection prevention and control practices in nursing homes. | 2017 | 28382547 |
| silver potentiates aminoglycoside toxicity by enhancing their uptake. | the predicted shortage in new antibiotics has prompted research for chemicals that could act as adjuvant and enhance efficacy of available antibiotics. in this study, we tested the effects of combining metals with aminoglycosides on escherichia coli survival. the best synergising combination resulted from mixing aminoglycosides with silver. using genetic and aminoglycoside uptake assays, we showed that silver potentiates aminoglycoside action in by-passing the pmf-dependent step, but depended up ... | 2017 | 28383153 |
| kick the bucket: one hospital system's journey to reduce clostridium difficile. | albert einstein defines insanity as doing the same thing over again but expecting different results. although the united states claims to reduce antibiotic abuse, practice strict isolation, and clean meticulously, the burden of clostridium difficile outpaces goals. unless innovative approaches are tried, we risk culling elderly, immunosuppressed, and otherwise debilitated populations. emergency departments are a primary access point for patients who are unable to wait for primary care. as a resu ... | 2017 | 28385299 |
| genome sequence of a toxin-positive clostridium difficile strain isolated from murine feces. | herein, we report the genome sequence of a clostridium difficile strain isolated from the feces of antibiotic-treated c57bl/6 mice. we have named this strain, which differs considerably from those of the previously sequenced c. difficile strains, lem1. | 2017 | 28385835 |
| oral teicoplanin as an alternative first-line regimen in clostridium difficile infection in elderly patients: a case series. | elderly patients are more susceptible to clostridium difficile infections (cdis). despite existing guidelines, there is no specific treatment for cdi in geriatrics. vancomycin is commonly used in the treatment of cdi. teicoplanin is an alternative glycopeptide which recently received marketing authorization approval for cdi in europe. | 2017 | 28386820 |
| detection of vancomycin-resistant enterococci (vre) in stool specimens submitted for clostridium difficile toxin testing. | the aim of this study was to determine the association between clostridium difficile (c. difficile) and vancomycin-resistant enterococcus (vre) and efficacy of screening stools submitted for c. difficile toxin assay for prevalence of vre. between april 2012 and february 2014, 158 stool samples submitted for c. difficile toxin to the marmara university microbiology laboratory, were included in the study. stool samples were analyzed by enzyme immuno assay test; vidas (biomerieux, france) for toxin ... | 2017 | 28389190 |
| effect of clostridium difficile prevalence in hospitals and nursing homes on risk of infection. | to assess the effect of facility clostridium difficile infection (cdi) prevalence on risk of healthcare facility (hfc) acquired cdi. | 2017 | 28394408 |
| risk factors for community-associated clostridium difficile infection in children. | to characterize the medication and other exposures associated with pediatric community-associated clostridium difficile infections (ca-cdis). | 2017 | 28396027 |
| clostridium difficile infection. | clostridium difficile infection (cdi) is the main cause of nosocomial diarrhea in industrialized countries and the source of a growing number of cases of diarrhea in the community. the outbreak of the hypervirulent strain belonging to ribotype 027 has increased the incidence and severity of cdi in some countries. although cdi usually courses as a mild diarrhea it can lead to severe forms such as toxic megacolon or septic shock. one of every 2 episodes of cdi is not diagnosed in spanish hospitals ... | 2017 | 28396132 |
| clostridioides difficile 630δerm in silico and in vivo - quantitative growth and extensive polysaccharide secretion. | antibiotic-associated infections with clostridioides difficile are a severe and often lethal risk for hospitalized patients, and can also affect populations without these classical risk factors. for a rational design of therapeutical concepts, a better knowledge of the metabolism of the pathogen is crucial. metabolic modeling can provide a simulation of quantitative growth and usage of metabolic pathways, leading to a deeper understanding of the organism. here, we present an elaborate genome-sca ... | 2017 | 28396843 |
| validity and reliability of administrative coded data for the identification of hospital-acquired infections: an updated systematic review with meta-analysis and meta-regression analysis. | to conduct an updated assessment of the validity and reliability of administrative coded data (acd) in identifying hospital-acquired infections (hais). | 2017 | 28397261 |
| risk of clostridium difficile infection in hematology-oncology patients colonized with toxigenic c. difficile. | the prevalence of colonization with toxigenic clostridium difficile among patients with hematological malignancies and/or bone marrow transplant at admission to a 566-bed academic medical care center was 9.3%, and 13.3% of colonized patients developed symptomatic disease during hospitalization. this population may benefit from targeted c. difficile infection control interventions. infect control hosp epidemiol 2017;38:718-720. | 2017 | 28397624 |
| the choice of the anchoring protein influences the interaction of recombinant bacillus spores with the immune system. | the technology of display of heterologous proteins on the surface of bacillus subtilis spores enables use of these structures as carriers of antigens for mucosal vaccination. currently, there are no technical possibilities to predict whether a designed fusion will be efficiently displayed on the spore surface and how such recombinant spores will interact with cells of the immune system. in this study, we compared four variants of b. subtilis spores presenting a fragment of a flid protein from cl ... | 2017 | 28399189 |
| impact of a multifaceted antimicrobial stewardship program: a front-line ownership driven quality improvement project in a large urban emergency department. | antibiotic overuse has promoted growing rates of antimicrobial resistance and secondary antibiotic-associated infections such as clostridium difficile (c. difficile). antimicrobial stewardship programs (asps) are effective in reducing antimicrobial use in the inpatient setting; however, the unique environment of the emergency department (ed) lends itself to challenges for successful implementation. front-line ownership (flo) methodology has been shown to be a potentially effective strategy for t ... | 2017 | 28399946 |
| survival of clostridium difficile spores at low water activity. | clostridium difficile is frequently found in meat and meat products. germination efficiency, defined as colony formation, was previously investigated at temperatures found in meat handling and processing for spores of strain m120 (animal isolate), r20291 (human isolate), and dk1 (beef isolate). in this study, germination efficiency of these spore strains was assessed in phosphate buffered saline (pbs, aw ∼1.00), commercial beef jerky (aw ∼0.82/0.72), and aw-adjusted pbs (aw ∼0.82/0.72). surface ... | 2017 | 28400013 |
| effect of metronidazole in infants with bowel habit change: irrelative to the clostridium difficile colonization. | clinical symptoms associated with clostridium difficile infection (cdi) can vary widely. carrier state without apparent symptoms is relatively common during infancy. the objective of this study was to determine the association of c. difficile colonization with bowel habit change and the effect of c. difficile colonization treatment on restoration of normal bowel habit. | 2017 | 28401056 |
| toxinotyping and sequencing of clostridium difficile isolates from patients in a tertiary care hospital of northern india. | clostridium difficile is an important cause of infectious colitis among hospitalized patients across the globe. the pathogenic potential of c. difficile in producing significant morbidity and mortality is mainly due to production of toxins a and b. the outbreaks of c. difficile infection (cdi) are due to changes in the genetic sequences of the organism. there is hardly any molecular study reported on the prevalent types of c. difficile strains in india. toxinotyping and sequencing of locally cir ... | 2017 | 28401147 |
| synthesis and biological evaluation of bile acid analogues inhibitory to clostridium difficile spore germination. | standard antibiotic-based strategies for the treatment of clostridium difficile infections disrupt indigenous microbiota and commonly fail to eradicate bacterial spores, two key factors that allow recurrence of infection. as an alternative approach to controlling c. difficile infection, a series of bile acid derivatives have been prepared that inhibit taurocholate-induced spore germination. these analogues have been evaluated in a highly virulent nap1 strain using optical density and phase-contr ... | 2017 | 28402634 |
| update on antimicrobial resistance in clostridium difficile: resistance mechanisms and antimicrobial susceptibility testing. | oral antibiotics such as metronidazole, vancomycin and fidaxomicin are therapies of choice for clostridium difficile infection. several important mechanisms for c. difficile antibiotic resistance have been described, including the acquisition of antibiotic resistance genes via the transfer of mobile genetic elements, selective pressure in vivo resulting in gene mutations, altered expression of redox-active proteins, iron metabolism, and dna repair, as well as via biofilm formation. this update s ... | 2017 | 28404671 |
| trends in the incidence and outcomes of hospitalized cancer patients with clostridium difficile infection: a nationwide analysis. | background: patients with cancer have several risk factors for clostridium difficile infection (cdi), but the impact of cdi on outcomes in this population needs elucidation. we analyzed the incidence of cdi and its impact on outcomes in patients with cancer using the national hospital discharge survey (nhds) database from 2001 to 2010. methods: diagnosis codes were used to identify patients with cancer and cdi events. demographics, diagnoses, length of stay (los), and discharge information were ... | 2017 | 28404757 |
| risk for clostridium difficile infection after allogeneic hematopoietic cell transplant remains elevated in the postengraftment period. | clostridium difficile infection (cdi) is a frequent cause of diarrhea among allogeneic hematopoietic cell transplant (hct) recipients. it is unknown whether risk factors for cdi vary by time posttransplant. | 2017 | 28405601 |
| improvement in the management of patients with clostridium difficile associated diarrhoea following changes to the wording of laboratory reports. | 2017 | 28408053 | |
| preoperative clostridium difficile infection does not affect pouch outcomes in patients with ulcerative colitis who undergo ileal pouch-anal anastomosis. | the operation of choice for patients with chronic ulcerative colitis (cuc) is restorative proctocolectomy with ileal pouch-anal anastomosis (ipaa). pouchitis is the most common complication after ipaa. the incidence of clostridium difficile infection (cdi) is higher in cuc patients than the general population and can lead to significant disease flares and higher rates of colectomy. we sought to determine the risk of pouchitis in patients with precolectomy cdi and 90-day postoperative ipaa compli ... | 2017 | 28410344 |
| clostridium difficile and cystic fibrosis: management strategies and the role of faecal transplantation. | clostridium difficile is a bacterial infection that colonises the gut in susceptible hosts. it is associated with exposure to healthcare settings and antibiotic use. it could be assumed that cystic fibrosis (cf) patients are a high-risk group for c.difficile. however, despite high carriage rates, cf patients have low rates of active disease. there are guidelines for the treatment of c.difficile, however little is published specific to treating c.difficile in cf. this article provides an overview ... | 2017 | 28411069 |
| capability of exopolysaccharide-producing lactobacillus paraplantarum bgcg11 and its non-producing isogenic strain nb1, to counteract the effect of enteropathogens upon the epithelial cell line ht29-mtx. | the putative protective role of the exopolysaccharide (eps)-producing lactobacillus paraplantarum bgcg11, and its non-eps-producing isogenic strain nb1, was tested upon ht29-mtx monolayers challenged with seven opportunistic pathogens. the probiotic strain lactobacillus rhamnosus lmg18243 (gg) was used as a reference bacterium. tested lactobacilli were able to efficiently reduce the attachment to ht29-mtx of most pathogens. lb. paraplantarum nb1 and lb. rhamnosus gg were more efficient reducing ... | 2015 | 28411984 |
| colonization by multidrug-resistant organisms in long-term care facilities in italy: a point-prevalence study. | to determine prevalence and risk factors for colonization by multidrug-resistant organisms (mdros) in long-term care facility (ltcf) residents in italy. genotypes of mdro isolates were investigated. | 2017 | 28412380 |
| clostridium difficile infection. | preventing clostridium difficile, the most common cause of health care-associated infections in hospitals and infectious disease death in the united states, is a national priority. increased rates of infection among low-risk individuals in the community call for community-based prevention efforts to halt the increasing spread of this highly contagious opportunistic infection. | 2017 | 28414622 |
| clostridium difficile bacteremia: report of two cases in french hospitals and comprehensive review of the literature. | we report two cases of bacteremia due to clostridium difficile from two french hospitals. the first patient with previously diagnosed rectal carcinoma underwent courses of chemotherapy, and antimicrobial treatment, and survived the c. difficile bacteremia. the second patient with colon perforation and newly diagnosed lung cancer underwent antimicrobial treatment in an icu but died shortly after the episode of c. difficile bacteremia. a review of the literature allowed the identification of 137 c ... | 2017 | 28417069 |
| antimicrobial effects of manuka honey on in vitro biofilm formation by clostridium difficile. | clostridium difficile is the cause of the nosocomial c. difficile infection (cdi). the conventional antibiotics used in cdi therapy are often unsuccessful, and recurrent infections may occur. biofilm formation by c. difficile is associated with chronic or recurrent infections; biofilms may contribute to virulence and impaired antimicrobial efficacy. manuka honey, derived from the manuka tree (leptospermum scoparium), is known to exhibit antimicrobial properties that are associated with its signi ... | 2017 | 28417271 |
| editorial: clostridium difficile and inflammatory bowel disease - is it always a bad combination? | 2017 | 28417498 | |
| the influence of maternal vaginal flora on the intestinal colonization in newborns and 3-month-old infants. | the role of maternal vaginal bacteria on the colonization of neonatal gut is still a matter of discussion. our aim was to estimate the role of maternal vaginal flora on the development of intestinal flora in neonates and 3-month-old infants. | 2017 | 28420276 |
| changes in composition of the gut bacterial microbiome after fecal microbiota transplantation for recurrent clostridium difficile infection in a pediatric heart transplant patient. | the microbiome is increasingly recognized as an important influence on human health and many of the comorbidities that affect patients after solid organ transplantation (sot) have been shown to involve changes in gut bacterial populations. thus, microbiome changes in an individual patient may have important health implications after sot but this area remains understudied. we describe changes in the composition of the fecal microbiome from a pediatric heart transplant recipient before and >2.5 ye ... | 2017 | 28421185 |
| bezlotoxumab and recurrent clostridium difficile infection. | 2017 | 28423298 | |
| bezlotoxumab and recurrent clostridium difficile infection. | 2017 | 28423299 | |
| bezlotoxumab and recurrent clostridium difficile infection. | 2017 | 28423300 | |
| bezlotoxumab and recurrent clostridium difficile infection. | 2017 | 28425276 | |
| quality of care and outcomes among hospitalized inflammatory bowel disease patients: a multicenter retrospective study. | half of patients with inflammatory bowel disease (ibd) require hospitalization. we sought to characterize inpatient quality indicators of care and outcomes during ibd-related hospitalizations at 4 major ibd referral centers in canada. | 2017 | 28426451 |
| loop ileostomy versus total colectomy as surgical treatment for clostridium difficile-associated disease: an eastern association for the surgery of trauma multicenter trial. | the mortality of patients with clostridium difficile-associated disease (cdad) requiring surgery continues to be very high. loop ileostomy (li) was introduced as an alternative procedure to total colectomy (tc) for cdad by a single-center study. to date, no reproducible results have been published. the objective of this study was to compare these two procedures in a multicentric approach to help the surgeon decide what procedure is best suited for the patient in need. | 2017 | 28426557 |
| detection of gastrointestinal pathogens in oncology patients by highly multiplexed molecular panels. | we compared the frequency of gastrointestinal (gi) pathogen detection in an oncology patient population by two multiplexed molecular assays, the luminex xtag® gastrointestinal pathogen panel (gpp, which identifies 14 gi pathogens) and the biofire gastrointestinal panel (bfgp, which identifies 22 gi pathogens). we additionally reviewed the clinical characteristics of patients tested with both panels. a total of 200 prospectively collected and 81 archived stool samples were tested by both panels. ... | 2017 | 28429164 |
| a review of the novel application and potential adverse effects of proton pump inhibitors. | proton pump inhibitors (ppis) are known as a class of pharmaceutical agents that target h(+)/k(+)-atpase, which is located in gastric parietal cells. ppis are widely used in the treatment of gastric acid-related diseases including peptic ulcer disease, erosive esophagitis and gastroesophageal reflux disease, and so on. these drugs present an excellent safety profile and have become one of the most commonly prescribed drugs in primary and specialty care. except for gastric acid-related diseases, ... | 2017 | 28429247 |
| ethical issues in fecal microbiota transplantation in practice. | fecal microbiota transplantation (fmt) has demonstrated efficacy and is increasingly being used in the treatment of patients with recurrent clostridium difficile infection. despite a lack of high-quality trials to provide more information on the long-term effects of fmt, there has been great enthusiasm about the potential for expanding its applications. however, fmt presents many serious ethical and social challenges that must be addressed as part of a successful regulatory policy response. in t ... | 2017 | 28430065 |
| reducing recurrence of c. difficile infection. | clostridium difficile infection (cdi) is facilitated by alteration of the microbiome following antibiotic administration. antimicrobial therapy directed against the pathogen can treat cdi. unfortunately, ∼20% of successfully treated patients will suffer recurrence. bezlotoxumab, a human monoclonal antibody, binds to c. difficile toxin b (tcdb), reducing recurrence presumably by limiting epithelial damage and facilitating microbiome recovery. | 2017 | 28431238 |
| prospective cluster controlled crossover trial to compare the impact of an improved hydrogen peroxide disinfectant and a quaternary ammonium-based disinfectant on surface contamination and health care outcomes. | quaternary ammonium-based (quat) disinfectants are widely used, but they have disadvantages. | 2017 | 28431849 |
| how well does transfer of bacterial pathogens by culture swabs correlate with transfer by hands? | in laboratory testing and in isolation rooms, pickup and transfer of health care-associated pathogens by premoistened rayon swabs correlated well with pickup and transfer by bare hands or moistened gloves. these results suggest that swab cultures provide a useful surrogate indicator of the risk for pathogen pickup and transfer by hands. | 2017 | 28431852 |
| results of the implementation of a multidisciplinary programme of faecal microbiota transplantation by colonoscopy for the treatment of recurrent clostridium difficile infection. | recurrent clostridium difficile infection (cdi) is common and often difficult to manage. faecal microbiota transplant (fmt) is an effective therapeutic tool in these cases, although its applicability and effectiveness in spain is currently unknown. | 2017 | 28433406 |
| clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable udp-glucose analogue. | clostridium difficile is the leading cause of hospital-acquired diarrhea and pseudomembranous colitis worldwide. the organism produces two homologous toxins, tcda and tcdb, which enter and disrupt host cell function by glucosylating and thereby inactivating key signalling molecules within the host. as a toxin-mediated disease, there has been a significant interest in identifying small molecule inhibitors of the toxins' glucosyltransferase activities. this study was initiated as part of an effort ... | 2017 | 28433497 |
| ribotypes associated with clostridium difficile outbreaks in brazil display distinct surface protein profiles. | clostridium difficile is a spore-forming anaerobic intestinal pathogen that causes clostridium difficile infection (cdi). c. difficile is the leading cause of toxin-mediated nosocomial antibiotic-associated diarrhea. the pathogenesis of cdi is attributed to two major virulence factors, tcda and tcdb toxins, that cause the symptomatic infection. c. difficile also expresses a number of key proteins, including cell wall proteins (cwps). s-layer proteins (slps) are cwps that form a paracrystalline s ... | 2017 | 28435010 |
| toxigenic clostridium difficile colonization among hospitalised adults; risk factors and impact on survival. | to establish risk factors for clostridium difficile colonization among hospitalized patients in england. | 2017 | 28435086 |
| [colonization rate of clostridium difficile in healthy children]. | objective: to learn the colonization of clostridium difficile in local healthy children and to investigate the colonization rate and toxin types of clostridium difficile at different ages. method: from september 2014 to january 2015 in a case observational study, healthy children's fecal specimens from the health care department of beijing children's hospital were collected. the children were divided into four groups according to age: <1 year old(n=53), 1-<3 years old(n=50), 3-<6 years old(n=50) ... | 2017 | 28441827 |
| "predictors of failure after single faecal microbiota transplantation in patients with recurrent clostridium difficile infection: results from a three-year cohort study"; methodological issues. | 2017 | 28442436 | |
| the effect of a piperacillin/tazobactam shortage on antimicrobial prescribing and clostridium difficile risk in 88 u.s. medical centers. | anti-infective shortages are a pervasive problem in the u.s. the objective of this study was to identify any associations between changes in antibiotic prescribing during a piperacillin/tazobactam (pip/tazo) shortage and hospital-onset clostridium difficile infection (ho-cdi) risk in 88 u.s medical centers. | 2017 | 28444166 |
| clostridium difficile: a bad bug goes into defensive mode. | 2017 | 28447375 | |
| clostridium difficile in england: can we stop washing our hands? - authors' reply. | 2017 | 28447949 | |
| clostridium difficile in england: can we stop washing our hands? | 2017 | 28447950 | |
| fecal microbiota transplantation for refractory and recurrent clostridium difficile infection: a case series of nine patients. | fecal microbiota transplantation (fmt) is a highly effective therapy for refractory and recurrent clostridium difficile infection (cdi). despite its excellent efficacy and recent widespread use, fmt has not been widely used in south korea thus far. we describe our experience with fmt to treat refractory/recurrent cdi. | 2017 | 28449424 |
| outcomes of fecal microbiota transplantation for clostridium difficile infection in patients with inflammatory bowel disease. | fecal microbiota transplantation (fmt) has recently been shown to be a promising therapy for recurrent and refractory clostridium difficile infections (cdi) despite lack of protocol standardization. patients with inflammatory bowel disease (ibd) present a particular challenge to cdi therapy as they are reported to have worse clinical outcomes, including higher colectomy rates and increased mortality. we aimed to assess the outcomes of fmt for recurrent cdi in patients with ibd at our healthcare ... | 2017 | 28451916 |
| efficacy and factors associated with treatment response of intravenous immunoglobulin in inpatients with refractory inflammatory bowel diseases. | the administration of intravenous immunoglobulin (ivig) has demonstrated promise in the treatment of medically refractory inflammatory bowel diseases (ibd). we aimed to identify factors associated with ivig failures in the treatment of refractory ibd. | 2017 | 28452863 |
| leapfrog hospital safety score, magnet designation, and healthcare-associated infections in united states hospitals. | healthcare-associated infections (hais) pose a challenge to patient safety. although studies have explored individual level, few have focused on organizational factors such as a hospital's safety infrastructure (indicated by leapfrog hospital safety score) or workplace quality (magnet recognition). the aim of the study was to determine whether magnet and hospitals with better leapfrog hospital safety scores have fewer hais. | 2017 | 28452915 |
| collateral damage during antibiotic treatment of c. difficile infection in the aged host: insights into why recurrent disease happens. | clostridium difficile infection (cdi) is one of the most common causes of healthcare-associated infections but an even bigger problem for the aging population. advanced age leads to higher incidence, higher mortality, and higher recurrences. in our study, recently published in the journal of infectious diseases, we investigated the effect of aging on cdi using a mouse model. we were able to demonstrate that aging leads to worse clinical outcomes, as well as lead to changes in microbiota composit ... | 2017 | 28453386 |
| comparison of the rates of clostridium difficile and bacteremia after delaying fluoroquinolone prophylaxis from day 0 to day +3 post autologous stem cell transplantation. | prophylactic fluoroquinolones are routinely administered after stem cell transplantation (sct) to prevent bacterial infection; however, fluoroquinolones may increase the risk of clostridium difficile infection, particularly in immunocompromised patients. this study is designed to evaluate the effect of a delay by 3 days in fluoroquinolone prophylaxis after autologous sct (asct) on the rates of c. difficile infection and bacteremia. a single-center retrospective cohort study was performed in 118 ... | 2017 | 28456140 |
| clostridium difficile. | clostridium difficile infections (cdis) have emerged as one of the principal threats to the health of hospitalized and immunocompromised patients. the importance of c difficile colonization is increasingly recognized not only as a source for false-positive clinical testing but also as a source of new infections within hospitals and other health care environments. in the last five years, several new treatment strategies that capitalize on the increasing understanding of the altered microbiome and ... | 2017 | 28457354 |
| effect of liberal blood transfusion on clinical outcomes and cost in spine surgery patients. | blood transfusions in spine surgery are shown to be associated with increased patient morbidity. the association between transfusion performed using a liberal hemoglobin (hb) trigger-defined as an intraoperative hb level of ≥10 g/dl, a postoperative level of ≥8 g/dl, or a whole hospital nadir between 8 and 10 g/dl-and perioperative morbidity and cost in spine surgery patients is unknown and thus was investigated in this study. | 2017 | 28458067 |
| withholding pantoprazole for stress ulcer prophylaxis in critically ill patients: a pilot randomized clinical trial and meta-analysis. | a decreased frequency of upper gastrointestinal bleeding and a possible association of proton pump inhibitor use with clostridium difficile and ventilator-associated pneumonia have raised concerns recently. the reevaluating the inhibition of stress erosions pilot trial determined the feasibility of undertaking a larger trial investigating the efficacy and safety of withholding proton pump inhibitors in critically ill patients. | 2017 | 28459708 |
| probiotics for prevention of clostridium difficile infection in hospitalized patients: is the jury still out? | 2017 | 28461190 | |
| efficacy and safety of ridinilazole compared with vancomycin for the treatment of clostridium difficile infection: a phase 2, randomised, double-blind, active-controlled, non-inferiority study. | clostridium difficile infection is the most common health-care-associated infection in the usa. we assessed the safety and efficacy of ridinilazole versus vancomycin for treatment of c difficile infection. | 2017 | 28461207 |
| expanding the armamentarium for the treatment of clostridium difficile infection. | 2017 | 28461208 | |
| second generation cephalosporin antibiotic prophylaxis and clostridium difficile infection in hip and knee arthroplasty. | introduction the use of broad spectrum cephalosporin antibiotics has been discouraged by the department of health in england because of the link to increased clostridium difficile infection rates. the aim of this study was to evaluate whether a local protocol that included the use of second generation cephalosporin (cefuroxime) antibiotics as a prophylactic agent was associated with increased risk of c difficile in elective hip and knee arthroplasty patients. methods a retrospective intention-to ... | 2017 | 28462657 |
| a multicenter randomized trial to determine the effect of an environmental disinfection intervention on the incidence of healthcare-associated clostridium difficile infection. | objective to determine the impact of an environmental disinfection intervention on the incidence of healthcare-associated clostridium difficile infection (cdi). design a multicenter randomized trial. setting in total,16 acute-care hospitals in northeastern ohio participated in the study. intervention we conducted a 12-month randomized trial to compare standard cleaning to enhanced cleaning that included monitoring of environmental services (evs) personnel performance with feedback to evs and inf ... | 2017 | 28462761 |
| the emergence of clostridium difficile infection in asia: a systematic review and meta-analysis of incidence and impact. | clostridium difficile infection (cdi) is the most common healthcare associated infection and is highly prevalent in europe and north america. limited data is available on the prevalence of cdi in asia. however, secular increases in prevalence of risk factors for cdi suggest that it may be emerging as a major cause of morbidity, highlighting the urgent need for a systematic study of the prevalence of cdi in asia. | 2017 | 28463987 |
| a combination of the probiotic and prebiotic product can prevent the germination of clostridium difficile spores and infection. | clostridium difficile infection (cdi) is one of the most prevalent healthcare associated infections in hospitals and nursing homes. different approaches are used for prevention of cdi. absence of intestinal lactobacilli and bifidobacteria has been associated with c. difficile colonization in hospitalized patients. our aim was to test a) the susceptibility of c. difficile strains of different origin and the intestinal probiotic lactobacillus plantarum inducia (dsm 21379) to various antimicrobial ... | 2017 | 28465256 |
| [effect of silver nanoparticles on anaerobic bacteria]. | the aim was to evaluate the antibacterial effect of silver nanoparticles on anaerobic bacteria. | 2017 | 28467592 |
| proton pump inhibitors and clostridium difficile infection. | 2017 | 28469228 | |
| [bezlotoxumab for the secondary prevention of clostridium difficile infection : modify i and modify ii studies]. | 2017 | 28470456 | |
| a retrospective comparison of fecal microbial transplantation methods for recurrent clostridium difficile infection. | antibiotic treatment of clostridium difficile infection (cdi) has a high failure rate. fecal microbiota transplantation (fmt) has proven very effective in treating these recurrences. | 2016 | 28471618 |
| microbicidal effects of weakly acidified chlorous acid water against feline calicivirus and clostridium difficile spores under protein-rich conditions. | sanitation of environmental surfaces with chlorine based-disinfectants is a principal measure to control outbreaks of norovirus or clostridium difficile. the microbicidal activity of chlorine-based disinfectants depends on the free available chlorine (fac), but their oxidative potential is rapidly eliminated by organic matter. in this study, the microbicidal activities of weakly acidified chlorous acid water (wacaw) and sodium hypochlorite solution (naclo) against feline calcivirus (fcv) and c. ... | 2017 | 28472060 |
| tracking microbial colonization in fecal microbiota transplantation experiments via genome-resolved metagenomics. | fecal microbiota transplantation (fmt) is an effective treatment for recurrent clostridium difficile infection and shows promise for treating other medical conditions associated with intestinal dysbioses. however, we lack a sufficient understanding of which microbial populations successfully colonize the recipient gut, and the widely used approaches to study the microbial ecology of fmt experiments fail to provide enough resolution to identify populations that are likely responsible for fmt-deri ... | 2017 | 28473000 |
| promoting appropriate urine culture management to improve health care outcomes and the accuracy of catheter-associated urinary tract infections. | published literature indicates that the unjustified ordering or improper collection of urine for urinalysis or culture from either catheterized patients or those without indwelling devices, or misinterpretation of positive results, often leads to adverse health care events, including increased financial burdens, overreporting of mandated catheter-associated urinary tract infection events, overtreatment of patients with antimicrobial agents, selection of multidrug-resistant organisms, and clostri ... | 2017 | 28476493 |
| in vitro and in vivo antagonistic activity of new probiotic culture against clostridium difficile and clostridium perfringens. | genus clostridium accompanies more than 200 known species and at least 30 among them are associated with human and animal diseases. at the moment, the treatment of clostridial infections is based on use of antibiotics. however, due to the european ban on the use of antibiotics in livestock production, novel therapeutic strategies for treatment of these hardly curable infections have been evaluated. hence, in this study the antimicrobial effect of newly designed probiotic culture consisted of nat ... | 2017 | 28477627 |
| higher incidence of clostridium difficile infection among individuals with inflammatory bowel disease. | studies of clostridium difficile infections (cdis) among individuals with inflammatory bowel disease (ibd) have used data from single centers or cdi administrative data codes of limited diagnostic accuracy. we determined the incidence, risk factors, and outcomes after cdi in a population-based cohort of patients with ibd and laboratory confirmation diagnoses of cdi. | 2017 | 28479377 |
| outcomes associated with antimicrobial de-escalation of treatment for pneumonia within the veterans healthcare administration. | de-escalation, an antimicrobial stewardship concept, involves narrowing broad-spectrum empiric antimicrobial therapy based on clinical data. current health outcomes evidence is lacking to support de-escalation. studying veterans healthcare administration pneumonia patients, de-escalation was associated with improved length of stay without affecting 30-day readmission or 30-day clostridium difficile infection rates. | 2017 | 28480242 |
| does adjunctive tigecycline improve outcomes in severe-complicated, nonoperative clostridium difficile infection? | severe clostridium difficile infection is associated with a high rate of mortality; however, the optimal treatment for severe- complicated infection remains uncertain for patients who are not candidates for surgical intervention. thus, we sought to evaluate the benefit of adjunctive tigecycline in this patient population using a retrospective cohort adjusted for propensity to receive tigecycline. we found that patients who received tigecycline had similar outcomes to those who did not, although ... | 2017 | 28480257 |
| primary outcomes from a phase 3, randomized, double-blind, active-controlled trial of surotomycin in subjects with clostridium difficile infection. | although the incidence of clostridium difficile infection (cdi) is increasing, available cdi treatment options are limited in terms of sustained response after treatment. this phase 3 trial assessed the efficacy and safety of surotomycin, a novel bactericidal cyclic lipopeptide, versus oral vancomycin in subjects with cdi. | 2017 | 28480267 |
| community environmental contamination of toxigenic clostridium difficile. | clostridium difficile infection is often considered to result from recent acquisition of a c difficile isolate in a healthcare setting. however, c difficile spores can persist for long periods of time, suggesting a potentially large community environmental reservoir. the objectives of this study were to assess community environmental contamination of toxigenic c difficile and to assess strain distribution in environmental versus clinical isolates. | 2017 | 28480289 |
| bezlotoxumab: could this be the answer for clostridium difficile recurrence? | to review the pharmacology, pharmacokinetics, efficacy, safety, and place in therapy of bezlotoxumab (bez), a novel monoclonal antibody against clostridium difficile toxin b. | 2017 | 28480750 |
| protective effect of carvacrol against gut dysbiosis and clostridium difficile associated disease in a mouse model. | this study investigated the effect of carvacrol (cr), a phytophenolic compound on antibiotic-associated gut dysbiosis and c. difficile infection in a mouse model. five to six-week-old c57bl/6 mice were randomly divided into seven treatment groups (challenge and control) of eight mice each. mice were fed with irradiated feed supplemented with cr (0, 0.05, and 0.1%); the challenge groups were made susceptible to c. difficile by orally administering an antibiotic cocktail in water and an intra-peri ... | 2017 | 28484429 |
| intraluminal administration of resiniferatoxin protects against clostridium difficile toxin a-induced colitis. | clostridium difficile toxin a is a colonic inflammatory agent that acts partially by activation of trpv1 (transient receptor potential vanilloid type 1). resiniferatoxin (rtx) is an excitotoxin that activates trpv1 at low concentrations and defunctionalizes trpv1 at high concentrations. rtx at various doses was injected intraluminally into isolated ileal segments in anesthetized rats. after 3 hours, the treated segments were removed and inflammation was assessed. this acute treatment with rtx re ... | 2017 | 28484490 |
| optimal control of vaccination rate in an epidemiological model of clostridium difficile transmission. | the spore-forming, gram-negative bacteria clostridium difficile can cause severe intestinal illness. a striking increase in the number of cases of c. difficile infection (cdi) among hospitals has highlighted the need to better understand how to prevent the spread of cdi. in our paper, we modify and update a compartmental model of nosocomial c. difficile transmission to include vaccination. we then apply optimal control theory to determine the time-varying optimal vaccination rate that minimizes ... | 2017 | 28484801 |
| thirty-day readmissions after hospitalization for clostridium difficile enteritis measures and predictors: a nationwide analysis. | 2017 | 28486996 | |
| a clostridium difficile alanine racemase affects spore germination and accommodates serine as a substrate. | clostridium difficile has become one of the most common bacterial pathogens in hospital-acquired infections in the united states. although c. difficile is strictly anaerobic, it survives in aerobic environments and transmits between hosts via spores. c. difficile spore germination is triggered in response to certain bile acids and glycine. although glycine is the most effective co-germinant, other amino acids can substitute with varying efficiencies. of these, l-alanine is an effective co-germin ... | 2017 | 28487371 |
| antimicrobial activity of natural products against clostridium difficile in vitro. | to investigate the antimicrobial activity of various natural products against clostridium difficile in vitro. | 2017 | 28489336 |