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tumor necrosis factor alpha is a promising circulating biomarker for the development of obstructive sleep apnea syndrome: a meta-analysis.obstructive sleep apnea syndrome (osas) is a chronic inflammatory disorder. the relationship between tumor necrosis factor alpha (tnf-alpha) and osas has been widely evaluated, but the results thus far remain inconclusive. we thereby decided to quantify the changes of tnf-alpha between osas patients and controls by a meta-analysis. this study complies with the moose guidelines. two reviewers independently searched articles and abstracted relevant data. in total, 47 articles (59 studies) were ana ...201728187003
molecular mechanisms of chronic wasting disease prion propagation.prion disease epidemics, which have been unpredictable recurrences, are of significant concern for animal and human health. examples include kuru, once the leading cause of death among the fore people in papua new guinea and caused by mortuary feasting; bovine spongiform encephalopathy (bse) and its subsequent transmission to humans in the form of variant creutzfeldt-jakob disease (vcjd), and repeated examples of large-scale prion disease epidemics in animals caused by contaminated vaccines. the ...201728193766
efficacy of the intravitreal sustained-release dexamethasone implant for diabetic macular edema refractory to anti-vascular endothelial growth factor therapy: meta-analysis and clinical implications.to assess the effect on best-corrected visual acuity (bcva) and efficacy of the intravitreal sustained-release 0.7 mg dexamethasone implant (ozurdex; allergan, irvine, ca) in patients with recalcitrant diabetic macular edema (dme).201728195619
systematic review and meta-analysis of the efficacy of epidermal grafting for wound healing.autologous skin grafting is an important method for wound coverage; however, it is an invasive procedure and can cause donor site morbidity. epidermal grafting (eg) enables epidermal transfer to wounds with minimal donor site morbidity. however, data to date have been heterogeneous. this study aims to synthesise the current evidence on eg for wound healing to establish the efficacy of this surgical technique. a comprehensive search in the medline, embase and central databases was conducted. the ...201728198101
the interrelation between hypothyroidism and glaucoma: a critical review and meta-analyses.data on the association between hypothyroidism and glaucoma are conflicting. we sought to shed light on this by conducting a critical review and meta-analyses. the meta-analyses were conducted in adherence with the widely accepted moose guidelines. using the medical subject heading (mesh) terms: hypothyroidism, myxoedema and glaucoma or intraocular pressure, case-control studies, cohort studies and cross-sectional studies were identified (pubmed) and reviewed. using meta-analysis, the relative r ...201728211200
detection and molecular characterization of the mosquito-borne filarial nematode setaria tundra in danish roe deer (capreolus capreolus).setaria tundra is a mosquito-borne filarial nematode of cervids in europe. it has recently been associated with an emerging epidemic disease causing severe morbidity and mortality in reindeer and moose in finland. here, we present the first report of s. tundra in six roe deer (capreolus capreolus) collected between october 2010 and march 2014 in denmark. the deer originated from various localities across the country: the eastern part of the jutland peninsular and four locations on the island zea ...201728229043
group or ungroup - moose behavioural response to recolonization of wolves.predation risk is a primary motivator for prey to congregate in larger groups. a large group can be beneficial to detect predators, share predation risk among individuals and cause confusion for an attacking predator. however, forming large groups also has disadvantages like higher detection and attack rates of predators or interspecific competition. with the current recolonization of wolves (canis lupus) in scandinavia, we studied whether moose (alces alces) respond by changing grouping behavio ...201728239401
aneurysm rebleeding after placement of external ventricular drainage: a systematic review and meta-analysis.the association between external ventricular drainage (evd) and aneurysm rerupture is still a controversial issue. we performed a systematic review and meta-analysis of published series reporting data of evd placement in aneurysmal subarachnoid hemorrhage (sah) with the aim to evaluate the relationship between ventricular drainage and aneurysm rebleeding.201728243810
the influence of sulfur and hair growth on stable isotope diet estimates for grizzly bears.stable isotope ratios of grizzly bear (ursus arctos) guard hair collected from bears on the lower stikine river, british columbia (bc) were analyzed to: 1) test whether measuring δ34s values improved the precision of the salmon (oncorhynchus spp.) diet fraction estimate relative to δ15n as is conventionally done, 2) investigate whether measuring δ34s values improves the separation of diet contributions of moose (alces alces), marmot (marmota caligata), and mountain goat (oreamnos americanus) and ...201728248995
androgen receptor gene cag repeat polymorphism and ovarian cancer risk: a meta-analysis.ovarian cancer is one of the common gynecological malignancies worldwide. it is usually diagnosed at a later stage, thus missing the best opportunity for treatment. despite the advancement of ovarian cancer treatment, the prognosis is still poor. androgen receptor (ar) may play a role in ovarian carcinogenesis. previous studies regarding the association between ar cag repeat length and ovarian cancer risk reported inconsistent results. therefore, we conducted a meta-analysis to evaluate the asso ...201728250337
morphological and molecular characterization of four sarcocystis spp., including sarcocystis linearis n. sp., from roe deer (capreolus capreolus) in italy.fresh (frozen/thawed) muscle samples from four 2-12-year-old roe deer (capreolus capreolus) from the sondrio province in north-eastern italy were examined under a dissecting microscope, and about 180 sarcocysts were isolated and identified to morphological type in wet mounts by light microscopy (lm). seventy-seven of these sarcocysts were subsequently examined by molecular methods, comprising polymerase chain reaction (pcr) amplification and sequencing of the partial cytochrome c oxidase subunit ...201728255918
the healthy weights initiative: the first 1,000 participants.according to statistics canada, the number of adults who are overweight or obese rises every year in canada. as such, it is obvious that various public policies are not working. after extensive community consultation, the healthy weights initiative (hwi) started in moose jaw and expanded to regina, saskatchewan, canada.201728260865
modelling moose-forest interactions under different predation scenarios at isle royale national park, usa.loss of top predators may contribute to high ungulate population densities and chronic over-browsing of forest ecosystems. however, spatial and temporal variability in the strength of interactions between predators and ungulates occurs over scales that are much shorter than the scales over which forest communities change, making it difficult to characterize trophic cascades in forest ecosystems. we applied the landis-ii forest succession model and a recently developed ungulate browsing extension ...201728263421
vestibular (dys)function in children with sensorineural hearing loss: a systematic review.the objective of this study is to provide an overview of the prevalence of vestibular dysfunction in children with snhl classified according to the applied test and its corresponding sensitivity and specificity.201728264605
risk factors for the development of autism spectrum disorder in children with tuberous sclerosis complex: protocol for a systematic review.tuberous sclerosis complex (tsc) is an autosomal dominant condition, caused by mutations in either the tsc1 or tsc2 gene. it has widespread systemic manifestations and is associated with significant neurological morbidity. in addition to seizures and cerebral pathology including cortical tubers, subependymal nodules, subependymal giant cell astrocytoma and abnormal white matter, there are recognised neuropsychiatric difficulties including intellectual disability, autism spectrum disorder (asd) a ...201728270230
gross measurements of the digestive tract and visceral organs of addax antelope (addax nasomaculatus) following a concentrate or forage feeding regime.differences in macroscopic measurements of the gastrointestinal tract have been hypothesized to correlate with the browser-grazer continuum in the natural diet of ruminants. however, to what extent these characteristics represent species-specific traits, or respond to the actually ingested diet, remains to be investigated. twelve surplus addax antelope (addax nasomaculatus) were divided into two groups and fed, for 3 months, either their usual diet, consisting of a concentrate feed with a limite ...201728295511
overweight or obesity in children aged 0 to 6 and the risk of adult metabolic-syndrome: a systematic review and meta-analysis.to identify an association between overweight or obesity in early childhood and metabolic syndrome in adults.201728295797
seven years of workplace drug testing in italy: a systematic review and meta-analysis.in italy, workplace drug testing (wdt) is compulsory by law for specific categories of workers since 2008, offering the opportunity to compare studies conducted within a single regulatory framework.201728304140
geographical and latitudinal variation in growth patterns and adult body size of swedish moose (alces alces).we examined the geographical pattern in growth and adult body size among 14 populations of swedish moose (alces alces) using data from 4,294 moose (≥1.5 years old) killed during the hunting season in 1989-1992. in both sexes, adult body mass was significantly positively correlated with latitude. moose in northern populations had a 15-20% larger adult body mass than moose in the south. juvenile body mass was correlated with neither latitude nor adult body mass. thus, variation in time (years) and ...199528306886
influence of size and density of browse patches on intake rates and foraging decisions of young moose and white-tailed deer.we examined the functional response and foraging behavior of young moose (alces alces) and white-tailed deer (odocoileus virginianus) relative to animal size and the size and distribution of browse patches. the animals were offered one, three, or nine stems of dormant red maple (acer rubrum) in hand-assembled patches spaced 2.33, 7, 14, or 21 m apart along a runway. moose took larger twig diameters and bites and had greater dry matter and digestible energy intake rates than did deer, but had low ...199528306920
effects of above-ground browsing by mammals on mycorrhizal infection in an early successional taiga ecosystem.using an exclosure experiment in the willow stage of primary succession on the floodplain of the tanana river, we tested the hypothesis that browsing can reduce mycorrhizal infection. we measured the effects winter browsing by moose (alcesalces) and snowshoe hare (lepusamericanus) had on mycorrhizal infection and fine root biomass of willow (salix spp.) and balsam poplar (populusbalsamifera). we found that protection from winter browsing increased ectomycorrhizal infection by 10% in the top 5 cm ...199728307473
life history patterns in female moose (alces alces): the relationship between age, body size, fecundity and environmental conditions.i examined the relationship between age, body size and fecundity in 833 female moose (alces alces) from 14 populations in sweden sampled during 1989-1992. data on population density, food availability and climatic conditions were also collected for each population. age and body mass were both significantly positively related to fecundity, measured as ovulation rate, among female moose. the relationship between the probability of ovulation and body mass was dependent on age with (1) a higher body ...199628307646
range-body mass interactions of a northern ungulate - a test of hypothesis.summer diet, summer temperature, length of the growth season and animal density appeared to best explain annual and regional differences in calf and yearling body mass in moose from southeastern norway. in general animals inhabiting steep, alpine landscapes had less body mass than animals using flat, low-altitude habitats. autumn body mass of calves and yearlings decreased with increasing snow depth during the preceding winter and spring. however, calf body mass was more influenced by the summer ...199928307755
diet overlap among ruminants in fennoscandia.information on overlap in resource use is central to understanding of interspecific exploitation competition and resource partitioning. despite this, measures of diet overlap among northern ruminants in fennoscandia is limited to one earlier study (reindeer and sheep). diet overlap between sympatric moose and roe deer calculated with schoener's index was 20.7% and 33.6% during summer (data from one area) and winter (data from two areas), respectively, whereas average diet overlap between moose a ...200028308406
moose and snowshoe hare competition and a mechanistic explanation from foraging theory.moose (alces alces) and snowshoe hare (lepus americanus) appear to compete with each other. this was determined using the "natural experiments" of populations found in sympatry and allopatry on islands at isle royale national park, michigan, and manipulated exclosures. the population densities from these areas are fit to a series of competition models based upon different competitive mechanisms (schoener 1974a), using non-linear regression techniques. a model of competition for food where the fo ...198428309404
optimal activity times and habitat choice of moose.a set of concepts was presented which could be used to model an animal's activity cycle and habitat choice as an optimization process. the model was applied to moose (alces alces) summer activity and its predictions were consistent with observed feeding times and habitat selections. the optimization model had a goal of maximizing daily feeding time at the least possible energetic cost. this goal was consistent with a foraging strategy that maximized the intake of some nutritional component, i.e. ...198128309929
diet shifts in moose due to predator avoidance.on isle royale, michigan, moose cows which have calves show a different distribution and diet from solitary adults and yearling moose. solitary adults and yearlings follow a feeding pattern predicted from the location of high nutrient plant growth. in the presence of wolves, they feed on the ridges of the main island, where they take advantage of plants that leaf early; only later in the season do they move to the small outlying islands where plant phenology is delayed by the cold water of lake ...198328310485
moose-wolf dynamics and the natural regulation of moose populations.in southwestern québec, non-harvested moose populations stabilize at a density of ≃0.40 animal·km(-2). in an attempt to test whether or not moose were regulated by predators, we investigated wolf predation near this equilibrium density (0.37) and at 2 lower densities (≃0.23, 0.17). scat analysis in summer and feeding observations in winter indicated a greater use of alternative food resources by wolves at lower moose densities. each wolf pack killed on average 5.3, 1.8, 1.1 moose·100 days in the ...198528311857
mineral licks as a sodium source for isle royale moose.natural mineral licks and their use by moose (alces alces) on isle royale national park, michigan, were studied during 1982-85. the distribution of known licks suggested that they occurred in association with glacial debris, primarily in the western portions of the island. moose utilized mineral springs extensively during the spring-summer period, and at least 5 licks were used year-round. during summer, a pronounced diel pattern of moose visitation was apparent, with peak use occurring between ...198628312093
body condition and population regulation by food resources in moose.in southwestern québec, non-harvested moose populations stabilize at a density of ≈0.40 animal·km(-2). in an attempt to test population regulation by food resources, we investigated moose body condition near this equilibrium density (0.37) and at 2 lower densities (0.22 and 0.17). annual population growth rates were evaluated at 4, 18, and 24% respectively. we predicted that moose in the high density area would exhibit growth retardation and poorer body condition, compared to moose in the lower ...198428312108
wolf predation and snow cover as mortality factors in the ungulate community of the bialowieża national park, poland.wolf-ungulate interactions were studied in the pristine deciduous and mixed forests of the bialowieża national park in 1985-1989. the study period included two severe and two mild winters. the community of ungulates inhabiting bialowieża national park consisted of red deer cervus elaphus, 55% of all ungulates; wild boar sus scrofa, 42%; and roe deer capreolus capreolus, moose alces alces, and european bison bison bonasus, about 1% each. the average size of red deer groups increased from 2.7 (sd ...199228312267
factors influencing choice of balsam fir twigs from thinned and unthinned stands by moose.moose were observed to browse preferentially on balsam fir (abies balsamea) trees in stands where the stem density had been mechanically reduced to about 2000 stems/ha from over 30,000 stems/ha. twigs from trees in thinned and unthinned stands were analyzed to test the hypotheses that moose were choosing thinned stands to maximize intake of a nutrient, or avoiding plant secondary compounds deliterious to digestion. analyses included: twig length, weight, diameter, acid detergent fiber, neutral d ...198928312645
moose teeth as monitors of environmental isotopic parameters.the radiocarbon activities of amino acids isolated from crown first molar dentin of moose born between 1948 and 1984 on isle royale national park, usa closely follows the bomb radiocarbon signal generated from atmospheric nuclear weapons testing. this demonstrates that these amino acids are metabolically inert and have recorded the isotopic parameters of the environment during the first year or two of the animal's life. the moose teeth amino acids provide both carbon and nitrogen isotopic chrono ...199028313144
effects of competition, herbivory and substrate disturbance on growth and size structure in pin cherry (prunus pensylvanica l.) seedlings.we examined separate and interactive effects of intraspecific competition, vertebrate browsing and substrate disturbance on the growth and size structure of pin cherry (prunus pensylvanica l.) in the first two seasons of growth after clearcutting, in a hardwoods forest in new hampshire, united states. over the 15-month study period, 97.5% of 1801 individuals survived, and mean plant height increased from 4-fold at high density to 5-fold at low density. relative height growth was significantly lo ...199428313972
moose herbivory, browse quality, and nutrient cycling in an alaskan treeline community.moose (alces alces) browsing on diamondleaf willow (salix planifolia pulchra) caused significant increases in subsequent growth of stems and leaves in treeline plant communities in central alaska, usa. willows growing in the shade were significantly more palatable for moose than those growing in the sun. moose density had strong effects on rates of nutrient cycling, ostensibly through effects of browsing and inputs from fecal and urinary nitrogen. moose are a keystone herbivore that likely media ...199328313986
the value of lncrna hulc as a prognostic factor for survival of cancer outcome: a meta-analysis.growing evidence from recent studies has shown that lncrna hulc plays a role in the development of multiple carcinomas. this meta-analysis aimed to analyze available data to identify the prognostic value of hulc in multiple tumors.201728315877
[current dental implant design and its clinical importance].the development of clinical implant dentistry was intensively affected by dental implant design improvement and innovation, which brought about new concept, even milestone-like changes of clinical protocol. the current improvements of dental implant design and their clinical importance could be highlighted as followings: 1) the implant apical design influences the implant preliminary stability in immediate implant. the apical 3-5 mm design of implant makes implant stable in immediate implant, be ...201728326723
angiosome-directed revascularization in patients with critical limb ischemia.direct revascularization (dr), according to the angiosome concept, provides direct blood flow to the site of tissue loss in patients with critical limb ischemia (cli). dr may lead to improved outcomes; however, evidence for this is controversial. this systematic review and meta-analysis investigated the outcomes of surgical and endovascular dr compared with indirect revascularization (ir) in patients with cli.201728342514
the prevalence extent of complementary and alternative medicine (cam) use among saudis.introduction: there is worldwide interest in the use of cam. studying cam in saudi population is important as it will reflect the influence of psychosocial, cultural and religious factors on health beliefs and behaviors. the objective of this study was to present an updated review on the use of cam practices in saudi arabia including commonly used types, common conditions for which it has been used and who uses cam. methods: this review used data from national surveys conducted in saudi arabia a ...201728344484
high-throughput dna sequencing of the moose rumen from different geographical locations reveals a core ruminal methanogenic archaeal diversity and a differential ciliate protozoal diversity.moose rumen samples from vermont, alaska and norway were investigated for methanogenic archaeal and protozoal density using real-time pcr, and diversity using high-throughput sequencing of the 16s and 18s rrna genes. vermont moose showed the highest protozoal and methanogen densities. alaskan samples had the highest percentages of methanobrevibacter smithii, followed by the norwegian samples. one norwegian sample contained 43 % methanobrevibacter thaueri, whilst all other samples contained < 10  ...201528348818
high prevalence of prion protein genotype associated with resistance to chronic wasting disease in one alberta woodland caribou population.chronic wasting disease (cwd) is a prion disease found in deer, elk and moose in north america and since recently, wild reindeer in norway. caribou are at-risk to encounter cwd in areas such as alberta, canada, where the disease spreads toward caribou habitats. cwd susceptibility is modulated by species-specific polymorphisms in the prion protein gene (prnp). we sequenced prnp of woodland caribou from 9 albertan populations. in one population (chinchaga) a significantly higher frequency of the 1 ...201728350512
laparoendoscopic single-site surgery versus conventional laparoscopy for hysterectomy: a systematic review and meta-analysis.to assess the safety and effectiveness of less compared to conventional hysterectomy.201728357561
moose-tree interactions: rebrowsing is common across tree species.plant strategies to resist herbivory include tolerance and avoidance. tolerance strategies, such as rapid regrowth which increases the palatability of new shoots, can lead to positive feedback loops between plants and herbivores. an example of such a positive feedback occurs when moose (alces alces) browse trees in boreal forests. we described the degree of change in tree morphology that accumulated over time in response to repeated browsing by moose, using an index of accumulated browsing. we e ...201728376769
serological testing of schmallenberg virus in swedish wild cervids from 2012 to 2016.schmallenberg virus (sbv) first emerged in europe in 2011, and in sweden in late 2012. the virus was still circulating in parts of europe in 2015. in recent testing, the virus has not been detected in swedish domestic animals, indicating that it is no longer circulating in sweden. it is not known if the virus has circulated and is still circulating in swedish wild cervid populations and whether wildlife can act as virus reservoirs. the aim of this study was to investigate whether sbv has circula ...201728376790
secular trends in the incidence of dementia in high-income countries: a protocol of a systematic review and a planned meta-analysis.a global dementia epidemic is projected for the year 2050 with an ever-rising number of individuals living with the syndrome worldwide. however, increasingly, studies are emerging from high-income countries (hic) that show a positive trend towards a possible decrease in dementia occurrence. therefore, we aim to systematically summarise evidence regarding secular trends in the incidence of dementia in hic.201728389488
sublethal lead exposure alters movement behavior in free-ranging golden eagles.lead poisoning of animals due to ingestion of fragments from lead-based ammunition in carcasses and offal of shot wildlife is acknowledged globally and raises great concerns about potential behavioral effects leading to increased mortality risks. lead levels in blood were correlated with progress of the moose hunting season. based on analyses of tracking data, we found that even sublethal lead concentrations in blood (25 ppb, wet weight), can likely negatively affect movement behavior (flight he ...201728414429
de novo comparative transcriptome analysis of genes involved in fruit morphology of pumpkin cultivars with extreme size difference and development of est-ssr markers.the genetic basis of fruit size and shape was investigated for the first time in cucurbita species and genetic loci associated with fruit morphology have been identified. although extensive genomic resources are available at present for tomato (solanum lycopersicum), cucumber (cucumis sativus), melon (cucumis melo) and watermelon (citrullus lanatus), genomic databases for cucurbita species are limited. recently, our group reported the generation of pumpkin (cucurbita pepo) transcriptome database ...201728435133
weekend versus weekday admission and short-term mortality: a meta-analysis of 88 cohort studies including 56,934,649 participants.it is widely accepted that higher mortality related to weekend admissions basically exists; however, there has been no systematic exploration of whether weekend admissions are associated with higher risk of death in patients on the basis of certain diagnoses, geographic regions, and study subtypes.a meta-analysis was performed according to the reporting guidelines of the meta-analysis of observational studies in epidemiology (moose compliant). literature search was conducted using electronic dat ...201728445269
guidance in author instructions of hematology and oncology journals: a cross sectional and longitudinal study.the debate about the value of biomedical publications led to recommendations for improving reporting quality. it is unclear to what extent these recommendations have been endorsed by journals. we analyzed whether specific recommendations were included in author instructions, which journal characteristics were associated with their endorsement, how endorsement of the domains changed and whether endorsement was associated with change of impact factor between 2010 and 2015.201728453528
a systematic review of intrapartum fetal head compression: what is the impact on the fetal brain?objective during labor the fetal head is subjected to pressure related to uterine contractions and maternal pushing. here we systematically review what is known about fetal head compression and its effects on fetal intracranial pressure, oxygenation, blood flow and cerebral function, and the plausibility that it might cause isolated fetal brain injury. study design systematic review of intrapartum fetal head compression and fetal brain injury in accordance with the moose methodology. the pubmed ...201728465865
the effect of posterior fossa decompression in adult chiari malformation and basilar invagination: a systematic review and meta-analysis.chiari malformation (cm) and basilar invagination (bi) are mesodermal malformations with disproportion between the content and volume of posterior fossa capacity and overcrowding of neural structures at the level of foramen magnum. several alternatives for posterior approaches are available, including extradural (ed), extra-arachnoidal, and intradural (id) approaches. the objectives are to evaluate the effect of several surgical techniques for posterior fossa decompression (pfd) in the outcomes ...201828466256
hysteroscopy in the treatment of uterine cesarean section scar diverticulum: a systematic review.the aim of this paper is to review and to analyze the results of previous studies dealing with hysteroscopic treatment of postcesarean scar defects. a systematic review of publications indexed in medline/pubmed database identified a total of 11 studies dealing with resectoscopic treatment of postcesarean scar defect. the review was conducted in line with the meta-analysis of observational studies in epidemiology (moose) guidelines and the prisma statement. in only few studies, patients were qual ...201728500899
continental divide: predicting climate-mediated fragmentation and biodiversity loss in the boreal forest.climate change threatens natural landscapes through shifting distribution and abundance of species and attendant change in the structure and function of ecosystems. however, it remains unclear how climate-mediated variation in species' environmental niche space may lead to large-scale fragmentation of species distributions, altered meta-population dynamics and gene flow, and disrupted ecosystem integrity. such change may be especially relevant when species distributions are restricted either spa ...201728505173
incorporating concentration dependence in stable isotope mixing models.stable isotopes are often used as natural labels to quantify the contributions of multiple sources to a mixture. for example, c and n isotopic signatures can be used to determine the fraction of three food sources in a consumer's diet. the standard dual isotope, three source linear mixing model assumes that the proportional contribution of a source to a mixture is the same for both elements (e.g., c, n). this may be a reasonable assumption if the concentrations are similar among all sources. how ...200228547016
association of microvascular dysfunction with late-life depression: a systematic review and meta-analysis.the etiologic factors of late-life depression are still poorly understood. recent evidence suggests that microvascular dysfunction is associated with depression, which may have implications for prevention and treatment. however, this association has not been systematically reviewed.201728564681
suicide rates after discharge from psychiatric facilities: a systematic review and meta-analysis.high rates of suicide after psychiatric hospitalization are reported in many studies, yet the magnitude of the increases and the factors underlying them remain unclear.201728564699
genetic variation and differentiation in scandinavian moose (alces alces): are large mammals monomorphic? 198028568470
eating frequency and weight and body composition: a systematic review of observational studies.the present review aimed to examine the association of eating frequency with body weight or body composition in adults of both sexes.201728578730
experimental life-cycle of varestrongylus eleguneniensis (nematoda: protostrongylidae) in a captive reindeer (rangifer tarandus tarandus) and a muskox (ovibos moschatus moschatus).the life-cycle of a recently described protostrongylid lungworm, varestrongylus eleguneniensis, which infects caribou, muskoxen, and moose from arctic and boreal regions of north america, was completed experimentally for the first time. a native north american slug species, deroceras laeve, was infected with the first-stage larvae (l1) isolated from the feces of wild muskoxen to generate third-stage larvae (l3). these were administered to a captive reindeer calf (250 l3) and an adult captive mus ...201728590168
psoriasis in latin america and the caribbean: a systematic review.psoriasis is a chronic inflammatory disease that generally affects the skin, nails and joints. the burden of psoriatic disease in latin america and the caribbean (lac) remains largely unknown. to estimate the burden of psoriasis in lac. we conducted a systematic review following the moose and prisma statements. we searched published studies in medline, embase, lilacs and central from 1st january 2000 to 5th august 2015. we included studies that reported incidence, prevalence, health resource use ...201728608530
association between chemokine cxc ligand 12 gene polymorphism (rs1746048) and coronary heart disease: a moose-compliant meta-analysis.recently a large number of investigations have implicated the association between the chemokine cxc ligand 12 gene polymorphism (rs1746048) and risk of coronary heart disease (chd), but the results remain debatable. the aim of our study was to provide more compelling evidence for the relationship between rs1746048 and chd risk. studies eligible for this meta-analysis were identified through electronic search of pubmed, embase, and cnki. two authors performed independent literature review and stu ...201728614256
scavenging on a pulsed resource: quality matters for corvids but density for mammals.human food subsidies can provide predictable food sources in large quantities for wildlife species worldwide. in the boreal forest of fennoscandia, gut piles from moose (alces alces) harvest provide a potentially important food source for a range of opportunistically scavenging predators. increased populations of predators can negatively affect threatened or important game species. as a response to this, restrictions on field dressing of moose are under consideration in parts of norway. however, ...201728619108
prevalence, incidence and aetiologies of pulmonary hypertension in africa: a systematic review and meta-analysis protocol.there are no data summarising the epidemiology of pulmonary hypertension (ph) among adults residing in africa. establishment of accurate epidemiological data on ph in this region may guide decision-making toward interventions to curb the burden of ph in africa. the aim of this systematic review is to determine the prevalence, incidence and aetiologies of ph among people residing in africa.201728624758
meta-analysis of determinants of survival following treatment of recurrent hepatocellular carcinoma.intrahepatic recurrence of hepatocellular carcinoma (hcc) following resection is common. however, no current consensus guidelines exist to inform management decisions in these patients. systematic review and meta-analysis of survival following different treatment modalities may allow improved treatment selection. this review aimed to identify the optimum treatment strategies for hcc recurrence.201728628947
a unique fatal moose attack mimicking homicide.fatalities caused by animal attacks are rare, but have the potential to mimic homicide. we present a case in which a moose attacked and killed a woman who was walking her dog in a forest. autopsy showed widespread blunt trauma with a large laceration on one leg in which blades of grass were embedded. flail chest was the cause of death. the case was initially conceived as homicide by means of a riding lawn mower. a review of the case by moose experts and analyses of biological trace material that ...201728631272
childhood psychiatric disorders as risk factor for subsequent substance abuse: a meta-analysis.to assess the prospective risk of developing substance-related disorders after childhood mental health disorders (i.e., attention-deficit/hyperactivity disorder [adhd], oppositional defiant disorder [odd] or conduct disorder [cd], anxiety disorder, and depression) using meta-analysis.201728647007
conservation of wildlife populations: factoring in incremental disturbance.progressive anthropogenic disturbance can alter ecosystem organization potentially causing shifts from one stable state to another. this potential for ecosystem shifts must be considered when establishing targets and objectives for conservation. we ask whether a predator-prey system response to incremental anthropogenic disturbance might shift along a disturbance gradient and, if it does, whether any disturbance thresholds are evident for this system. development of linear corridors in forested ...201728649339
decline of heterozygosity in a large but isolated population: a 45-year examination of moose genetic diversity on isle royale.wildlife conservation and management approaches typically focus on demographic measurements to assess population viability over both short and long periods. however, genetic diversity is an important predictor of long term population vitality. we investigated the pattern of change in genetic diversity in a large and likely isolated moose (alces alces) population on isle royale (lake superior) from 1960-2005. we characterized samples, partitioned into five different 5-year periods, using nine mic ...201728729957
ninety-nine de novo assembled genomes from the moose (alces alces) rumen microbiome provide new insights into microbial plant biomass degradation.the moose (alces alces) is a ruminant that harvests energy from fiber-rich lignocellulose material through carbohydrate-active enzymes (cazymes) produced by its rumen microbes. we applied shotgun metagenomics to rumen contents from six moose to obtain insights into this microbiome. following binning, 99 metagenome-assembled genomes (mags) belonging to 11 prokaryotic phyla were reconstructed and characterized based on phylogeny and cazyme profile. the taxonomy of these mags reflected the overall ...201728731473
contextual social inequities and occurrence of dental caries in adolescents: a systematic review.this systematic review sought to determine whether there is consistent evidence of the association between contextual social inequities and the occurrence of dental caries in adolescents.201828752158
what is the best revascularization strategy for acute occlusive arterial mesenteric ischemia: systematic review and meta-analysis.acute mesenteric ischemia (ami) is a life-threatening disease that leads to bowel infarction and death. the optimal management of ami remains controversial. the present meta-analysis aimed to estimate the prognostic impact of surgical (sg) versus endovascular or hybrid intervention (ev) as the first-line treatment for acute arterial occlusive mesenteric ischemia and to assess whether endovascular strategy was actually effective in reducing bowel resection.201828752257
enantioselectivity of anteiso-fatty acids in hitherto uninspected sample matrices.anteiso-fatty acids (afas) are chiral molecules due to a methyl substituent on the antepenultimate carbon of the otherwise straight acyl chain. 12-methyltetradecanoic acid (a15:0) and 14-methylhexadecanoic acid (a17:0) are the predominant afas in nature but their individual contributions e.g. to food lipids are usually low. enantioselective data has been collected in fish, bovine milk/cheese, and brussels sprouts. in this study, we determined the enantioselectivity of a15:0 and a17:0 in shea but ...201728753519
collaborative goal setting with elderly patients with chronic disease or multimorbidity: a systematic review.it is challenging to use shared decision-making with patients who have a chronic health condition or, especially, multimorbidity. a patient-goal-oriented approach can thus be beneficial. this study aims to identify and evaluate studies on the effects of interventions that support collaborative goal setting or health priority setting compared to usual care for elderly people with a chronic health condition or multimorbidity.201728760149
state-dependent behavior alters endocrine-energy relationship: implications for conservation and management.glucocorticoids (gc) and triiodothyronine (t3) are two endocrine markers commonly used to quantify resource limitation, yet the relationships between these markers and the energetic state of animals has been studied primarily in small-bodied species in captivity. free-ranging animals, however, adjust energy intake in accordance with their energy reserves, a behavior known as state-dependent foraging. further, links between life-history strategies and metabolic allometries cause energy intake and ...201728777884
association between hiv infection and prevalence of erectile dysfunction: a systematic review and meta-analysis.the prevalence of erectile dysfunction (ed) in men positive for hiv has been reported to exceed the baseline of the general population. however, no meta-analysis or conclusive review has investigated whether individuals with hiv infection have a significantly higher prevalence of ed.201728778576
incidence, prognostic factors and impact of postoperative delirium after major vascular surgery: a meta-analysis and systematic review.although postoperative delirium is a common complication and increases patient care needs, little is known about the predictors and outcomes of delirium in patients having vascular surgery. this review aimed to determine the incidence, prognostic factors and impact of postoperative delirium in vascular surgical patients. medline and embase were systematically searched for articles published between january 2000 and january 2016 on delirium after vascular surgery. the primary outcome was the inci ...201728784053
time trends and exposure determinants of lead and cadmium in the adult population of northern sweden 1990-2014.this study follows cadmium and lead concentrations in blood in the adult population in northern sweden over 24 years.201728787621
association of androgen deprivation therapy and depression in the treatment of prostate cancer: a systematic review and meta-analysis.there is increasing evidence that androgen deprivation therapy (adt) may be associated with depression. existing studies have shown conflicting results.201728803700
whole-genome sequences of odocoileus hemionus deer adenovirus isolates from deer, moose and elk are highly conserved and support a new species in the genus atadenovirus.we present the first complete genome sequence of odocoileus hemionus deer adenovirus 1 (odadv-1). this virus can cause sporadic haemorrhagic disease in cervids, although epizootics with high mortality have occurred in california. odadv-1 has been placed in the genus atadenovirus, based on partial hexon, pviii and fibre genes. ten field isolates recovered from naturally infected mule deer (odocoileus hemionus), white-tailed deer (odocoileus virginiana) and moose (alces alces) from wyoming, black- ...201728809152
the structure of the infectious prion protein and its propagation.the prion diseases, which include creutzfeldt-jakob disease in humans, chronic wasting disease in cervids (i.e., deer, elk, moose, and reindeer), bovine spongiform encephalopathy in cattle, as well as sheep and goat scrapie, are caused by the conversion of the cellular prion protein (prp(c)) into a disease-causing conformer (prp(sc)). prp(c) is a regular, gpi-anchored protein that is expressed on the cell surface of neurons and many other cell types. the structure of prp(c) is well studied, base ...201728838667
hypofractionated radiation therapy for basal and squamous cell skin cancer: a meta-analysis.to characterize the cosmetic outcomes and local recurrence (lr) rates of various hypofractionated radiation therapy (rt) regimens for skin basal and squamous cell cancers (bccs/sccs).201728843727
association of sleep-disordered breathing with cognitive function and risk of cognitive impairment: a systematic review and meta-analysis.growing evidence suggests an association between sleep-disordered breathing (sdb) and cognitive decline in elderly persons. however, results from population-based studies have been conflicting, possibly owing to different methods to assess sdb or cognitive domains, making it difficult to draw conclusions on this association.201728846764
x chromosome evolution in cetartiodactyla.the phenomenon of a remarkable conservation of the x chromosome in eutherian mammals has been first described by susumu ohno in 1964. a notable exception is the cetartiodactyl x chromosome, which varies widely in morphology and g-banding pattern between species. it is hypothesized that this sex chromosome has undergone multiple rearrangements that changed the centromere position and the order of syntenic segments over the last 80 million years of cetartiodactyla speciation. to investigate its ev ...201728858207
experimental moose reduction lowers wolf density and stops decline of endangered caribou.the expansion of moose into southern british columbia caused the decline and extirpation of woodland caribou due to their shared predators, a process commonly referred to as apparent competition. using an adaptive management experiment, we tested the hypothesis that reducing moose to historic levels would reduce apparent competition and therefor recover caribou populations. nested within this broad hypothesis were three specific hypotheses: (1) sport hunting could be used to substantially reduce ...201728875080
rna-sequence data normalization through in silico prediction of reference genes: the bacterial response to dna damage as case study.measuring how gene expression changes in the course of an experiment assesses how an organism responds on a molecular level. sequencing of rna molecules, and their subsequent quantification, aims to assess global gene expression changes on the rna level (transcriptome). while advances in high-throughput rna-sequencing (rna-seq) technologies allow for inexpensive data generation, accurate post-processing and normalization across samples is required to eliminate any systematic noise introduced by ...201728878825
diabetes and pressure ulcer risk in hip fracture patients: a meta-analysis.the aim of this study was to assess the relationship between diabetes and pressure ulcer (pu) risk in patients with hip fractures.201728880760
association between mdm2 snp309, p53 arg72pro, and hepatocellular carcinoma risk: a moose-compliant meta-analysis.epidemiological studies have determined the associations between polymorphisms on the promoter of mdm2 (snp309) and the codon 72 on exon 4 of p53 (p53 arg72pro) and the risk of hepatocellular carcinoma (hcc); however, the results were not always consistent. the aim of the present meta-analysis was to evaluate the overall associations between these 2 variants and hcc risk.the medline, web of science, embase, cochrane library, and cnki databases were searched for eligibility studies and the data w ...201728885338
immunomodulatory treatments for persistent and chronic immune thrombocytopenic purpura: a prisma-compliant systematic review and meta-analysis of 28 studies.corticosteroid sparing is required in 15% to 40% of adults with persistent or chronic primary immune thrombocytopenic purpura (itp). herein, the efficacy of immunomodulatory drugs (dapsone, interferon alpha, danazol, and hydroxychloroquine as second-third-line therapies in itp is investigated.201728906353
cognitive effects of labeled addictolytic medications.alcohol, tobacco, and illegal drug usage is pervasive throughout the world, and abuse of these substances is a major contributor to the global disease burden. many pharmacotherapies have been developed over the last 50years to target addictive disorders. while the efficacy of these pharmacotherapies is largely recognized, their cognitive impact is less known. however, all substance abuse disorders are known to promote cognitive disorders like executive dysfunction and memory impairment. these im ...201828919445
the use of the model of occupational self efficacy in improving the cognitive functioning of individuals with brain injury: a pre- and post-intervention study.individuals diagnosed with a traumatic brain injury (tbi) often experience major limitations in returning to work despite participating in rehabilitation programmes.201728922182
modelling time to population extinction when individual reproduction is autocorrelated.in nature, individual reproductive success is seldom independent from year to year, due to factors such as reproductive costs and individual heterogeneity. however, population projection models that incorporate temporal autocorrelations in individual reproduction can be difficult to parameterise, particularly when data are sparse. we therefore examine whether such models are necessary to avoid biased estimates of stochastic population growth and extinction risk, by comparing output from a matrix ...201728925038
the accuracy of the broselow tape as a weight estimation tool and a drug-dosing guide - a systematic review and meta-analysis.the broselow tape is widely used as a weight-estimation device and drug-dosing guide aid, but concerns about its accuracy and its efficacy have emerged in the last decade. the aim of this study was to systematically review the literature to analyse the accuracy of the broselow tape as a weight estimation device and review evidence of its utility as a drug-dosing guide.201728958796
long-term survival of women with breast cancer. overview supportive care needs assessment instruments.worldwide, breast cancer is the fifth leading cause of cancer death (after lung, stomach, liver and colon cancer), while among women it is first on the list. the incidence of breast cancer has made a dramatic increase since 1970 which is partly interpreted by the modern western life standards. the expected risk of breast cancer throughout a lifespan of an average is 1 in 11 women. the five-year survival rates for breast cancer are at 80% if it has not spread, and only at 40% for the metastatic t ...201728971436
association of krouse classification for sinonasal inverted papilloma with recurrence: a systematic review and meta-analysis.the risk factors for the recurrence of sinonasal inverted papilloma are still unclear.201728973390
inflammatory bowel disease and eating disorders: a systematized review of comorbidity.research has shown that there is an association between inflammatory bowel disease, anxiety and mood disorders, however little is known about their association with eating disorders. in this paper we will present a case of a young female with a comorbid diagnosis of inflammatory bowel disease and eating disorder, and then discuss the results from a systematic review of the literature, describing published cases of patients with the same condition.201728992897
does caesarean section affect breastfeeding practices in china? a systematic review and meta-analysis.objectives to ascertain the association between caesarean delivery and breastfeeding practices in china. methods we conducted a systematic review and meta-analysis following the preferred reporting items for systematic reviews and meta-analyses (prisma) and meta-analysis of observational studies in epidemiology (moose) guidelines. electronic databases of cnki, medline, embase, cinahl, proquest and science direct were searched and screened to identify relevant articles from january 1990 to june 2 ...201729019000
the value of lncrna neat1 as a prognostic factor for survival of cancer outcome: a meta-analysis.the present meta-analysis aimed to analyze available data to identify the prognostic role of neat1 in multiple carcinomas. a systematic search was performed by using several computerized databases from inception to june 7, 2017. the quantity of the publications was assessed according to moose checklist. pooled hrs with 95% ci was calculated to summarize the effect. a total of 12 studies with 3,262 cancer patients were pooled in the analysis to evaluate the prognostic value of neat1 in multiple t ...201729026116
stoichiometric distribution models: ecological stoichiometry at the landscape extent.human activities are altering the fundamental geography of biogeochemicals. yet we lack an understanding of how the spatial patterns in organismal stoichiometry affect biogeochemical processes and the tools to predict the impacts of global changes on biogeochemical processes. in this contribution we develop stoichiometric distribution models (stdms), which allow us to map spatial structure in resource elemental composition across a landscape and evaluate spatial responses of consumers. we parame ...201729027338
outcome of intracerebral haemorrhage related to non-vitamin k antagonists oral anticoagulants versus vitamin k antagonists: a comprehensive systematic review and meta-analysis.the characteristics and natural history of acute non-vitamin k antagonists oral anticoagulants (noac)-associated intracerebral haemorrhage (ich) are largely unknown. we performed a comprehensive systematic review and meta-analysis to compare baseline ich volume, haematoma expansion and clinical outcomes between noac-ich versus vitamin k antagonists-ich (vka-ich).201729030422
risk assessment of dietary lead exposure among first nations people living on-reserve in ontario, canada using a total diet study and a probabilistic approach.indigenous peoples have elevated risk of lead (pb) exposure as hunted traditional food can be contaminated with lead-containing ammunition. recent scientific consensus states that there is no threshold level for pb exposure. the objective of this study was to estimate dietary exposure to pb among first nations living on-reserve in the province of ontario, canada. a total diet study was constructed based on a 24-h recall and pb concentrations for traditional foods from the first nations food, nut ...201829031094
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