Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| novel sex differences in linkage values and meiotic chromosome behaviour in a marsupial. | there have been few reported family studies of gene segregation in marsupials and no report on genetic linkage in a marsupial species. the paucity of such genetic data probably stems from the lack of marsupial species sufficiently well adapted to a laboratory environment to give the abundant progeny from controlled crosses which are required in such work. a colony of the fat-tailed insectivore sminthopsis crassicaudata (marsupialia: dasyuridae), which was established in the r. a. fisher laborato ... | 2010 | 3748181 |
| susceptibility of rats to infection with toxocara pteropodis. | infective eggs of toxocara pteropodis were administered to wistar rats via oral and parenteral routes. third-stage larvae were recovered from the livers of suckling young 8 days after oral infection, and from livers and lungs after intraperitoneal or subcutaneous inoculation of eggs. these larvae were short-lived as none were found in suckling mice killed 2 weeks post-infection. larvae were not recovered from tissues of rats aged 22 days or more when inoculated orally, indicating that refractori ... | 1986 | 3751231 |
| the assessment of denial and physical complaints: the validity of the hy scale and associated mmpi signs. | little and fisher (1958) have demonstrated that the mmpi hysteria (hy) scale consists primarily of items that address the denial of psychological problems (the dn scale) and items that involve the admission of physical problems (the ad scale). the traditional interpretation of an elevated hy score implies that both dn and ad subscales are elevated significantly. using samples of psychiatric (n = 1,246), medical (n = 330), and chronic pain patients (n = 126), the effectiveness of the hy scale and ... | 1986 | 3760208 |
| a physico-chemical comparison of aortic receptors in rat hypertension models. | rat models of genetic hypertension include spontaneous hypertension and resistance or sensitivity to mineralocorticoid and salt induced hypertension. previously, altered aldosterone binding to corticoid receptor i was found in aortic smooth muscle cells cultured from fischer 344 rats which are extremely resistant to steroid and salt induced hypertension. the corticoid receptor i of fisher 344 rats had a lower affinity than that of salt sensitive wistar-kyoto controls, as well as spontaneously hy ... | 1986 | 3762307 |
| in vitro covalent binding of 14c-mibolerone to rat liver microsomes. | mibolerone (17-hydroxy-7,17-dimethylestr-4-en-3-one; 7 alpha-17 alpha dimethyl-19-nortestosterone) is being marketed by the upjohn company for the inhibition of estrus in bitches. the aim of this study was to determine the extent of covalent binding of mibolerone to rat liver microsomes. liver microsomes were obtained from control and phenobarbitol-treated female fisher rats, and were incubated with 14c-mibolerone at 37 degrees c for 10 minutes. no covalent binding to macromolecules was observed ... | 1986 | 3766302 |
| significant increase in immunosuppressive acidic protein (iap) in serum of patients with multiple sclerosis and other inflammatory neurological disorders. | iap, a type of alpha 1-acid glycoprotein, is mainly produced by macrophages when stimulated in the presence of circulating immune complexes or some inflammatory substances. we assayed the serum levels of iap by a single radial immunodiffusion method. the normal level of iap is below 500 micrograms/ml (385 +/- 73). in multiple sclerosis patients, however, iap increased during exacerbation (630 +/- 191) and decreased during the inactive stage (433 +/- 170). eighty-five percent of patients with neu ... | 1986 | 3772394 |
| a comparison of the response of woodchucks and rats to variations in dietary lipotrope and protein content. | juvenile woodchucks and weanling fisher f344 rats were fed purified diets with or without supplemental lipotropic factors (choline, methionine, folic acid and vitamin b-12). the diets contained 10 or 20% protein. lower weight gain due to low protein was observed in both species, while lipotrope depletion resulted in lower gain in male rats only. urinary excretion of formimino-glutamic acid was higher due to low lipotrope in both species, as was relative liver weight. in rats, lipotrope depletion ... | 1986 | 3772530 |
| independence of in vitro iron absorption from mucosal transferrin content in rat jejunal and ileal segments. | isolated non blood-perfused intestinal segments from normal and iron-deficient rats were used in vitro. a modification of the luminal perfusion method according to fisher and parsons allowed the comparison of iron and transferrin quantities in the serosal fluid at 15 min intervals. iron transfer in jejunal and ileal segments was directly proportional to the luminal iron concentration within a dose range of 1 to 100 mumol/l, did not show saturation characteristics and was linear over time. jejuna ... | 1986 | 3779112 |
| 2,3-dialkyl(dimethylamino)indoles: interaction with 5ht1, 5ht2, and rat stomach fundal serotonin receptors. | 2,3-dialkyl(dimethylamino)indoles, synthesized via the fisher indole synthesis, were found to weakly bind to 5ht1 and 5ht2 sites in brain cortical membranes (ic50 greater than 1 microm at both sites for all compounds). these (dimethylamino)indoles were relatively potent antagonists of the serotonin receptor in the rat stomach fundus. at higher concentrations, several of the compounds were weak agonists at this receptor. for direct comparison with data obtained in the isolated rat fundus, antagon ... | 1986 | 3783602 |
| toluidine blue in the detection of perineal lacerations in pediatric and adolescent sexual abuse victims. | posterior fourchette lacerations are suggestive of sexual assault, and toluidine blue dye has increased the detection of these lacerations in adult rape victims. this study investigated the use of toluidine blue dye in the pediatric (0 to 10 years) and adolescent (11 to 18 years) patients to detect posterior fourchette lacerations in sexually abused and control populations. application of toluidine blue dye increased the detection rate of posterior fourchette lacerations from 4% (1/25) to 28% (7 ... | 1986 | 3786029 |
| private alleles in a partially isolated population. ii. distribution of persistence time and probability of emigration. | two diffusion limits were derived from a discrete wright-fisher model of migration, mutation, and selection with an arbitrary degree of dominance. instantaneous killing of the process due to emigration of a mutant leads to one of two diffusion processes with a killing term. one (weak gene flow) is the boundary case of the other (strong gene flow), which can cover a wide range of gene flow. the diffusion process subject to strong gene flow is similar to that studied by s. karlin and s. tavaré (19 ... | 1986 | 3787501 |
| dispersal and other population parameters of aedes aegypti in an african village and their possible significance in epidemiology of vector-borne diseases. | dispersal of aedes aegypti aegypti adults within shauri moyo, an african village in the rabai area north of mombasa, kenya, was studied using the mark-release-recapture method. a total of 920 mosquitoes were captured and uniquely marked, of which 828 (90%) were released and 332 (40%) recaptured. a great majority of mosquitoes were recaptured once, but some individuals were recaptured up to 10 times. most females visited 1 or 2 houses (40.8%, 44.9%, respectively), but there were females that visi ... | 1986 | 3789275 |
| preneoplastic and neoplastic growth of xenotransplanted lung-derived human cell lines using deepithelialized rat tracheas. | the human lung tumor-derived cell lines a549, calu-1, calu-3, hut292, and sw900 and the transformed human bronchial epithelial cell line tbe-1, that was transfected with the v-harvey-ras oncogene, were inoculated into deepithelialized fisher 344 rat tracheas (5 x 10(5) cells/trachea). after the ends of the tracheas were sealed, the tracheas were transplanted into s.c. tissues of nude mice. in a parallel experiment, 1 x 10(6) cells from each of these cell lines were injected s.c. histological exa ... | 1987 | 3791242 |
| mechanical responses of developing fisher rat heart. effects of steroid hormone. | age-dependent changes in the mechanical responses of developing fisher rat heart during the first three postnatal weeks were studied in relation to the hypothesis that the abnormality observed in the mechanical responses of the rat heart might be calcium related. therefore the effect of frequency of stimulation as well as the response to calcium, epinephrine and ouabain on hearts of untreated and cortisol-treated rats was compared. the positive force-frequency response observed in fetal rat hear ... | 1986 | 3794225 |
| irradiation alone or combined with hyperthermia in the treatment of recurrent carcinoma of the breast in the chest wall: a nonrandomized comparison. | tumour response and control (freedom from local relapse) were compared in two non-randomized groups of patients with recurrences from carcinoma of the breast (95 per cent in the chest wall and 5 per cent in the axillary or supraclavicular lymph nodes) receiving treatment at the mallinckrodt institute of radiology. one group, comprising 48 patients treated between march 1978 and december 1984, received varying doses of irradiation (2000-4000 cgy in fractions of 400 cgy every 72 h) followed by loc ... | 2006 | 3794415 |
| lipid deposition in the aorta of adjuvant arthritic rats with hypercholesterolemia. | this study offers findings which should aid in the development of a convenient animal model of atherosclerosis. inbred fisher strain rats were fed an atherogenic diet containing 1.5% cholesterol and 0.5% cholic acid and given a single subcutaneous injection of adjuvant (mycobacterium butyricum) into the base of the tail. the animals were maintained for 8 weeks. rats given the atherogenic diet showed markedly increased serum cholesterol levels, and all of those given the adjuvant injection develo ... | 1986 | 3795624 |
| age-related increased susceptibility of male fischer 344 rats to acetaminophen nephrotoxicity. | male fischer 344 rats classified as young (2-4 months), middle-aged (12-14 months) and aged (22-25 months) received 300, 600 or 800 mg/kg acetaminophen (apap) intraperitoneally and were sacrificed 24 hr later. blood urea nitrogen (bun) concentration and urinary glucose and osmolality were determined. in addition, kidneys were evaluated for histopathological changes. apap did not affect osmolality or bun concentrations and failed to produce lesions after any dose in young rats. osmolality was dec ... | 1986 | 3796197 |
| met-enkephalin, age and anatomy: a microiontophoretic study in the hippocampus. | met-enkephalin, administered microiontophoretically, produced a greater increase in firing in cells in area ca 3-4 in the hippocampus of both young and aged fisher 344 rats than it did in the ca 1 area. furthermore, the effect of met-enkephalin on neuronal firing rates was not as great in old rats as it was in young rats. finally, 20-40 na of met-enkephalin produced an increase in firing in old rats that was equivalent to the difference (2.5 spikes/sec) in baseline firing between old (2.6 spikes ... | 1987 | 3796220 |
| blood flow in diethylstilbestrol-induced anterior pituitary gland hyperplasia. | anterior pituitary hyperplasia was developed in female fisher 344 rats by subcutaneously implanted slow-release diethylstilbestrol (des) capsules. blood flow was measured in two separate areas of the adenohypophysis using hydrogen clearance method at 6, 9, 10, and 13 weeks after the implantation. blood flow progressively decreased while the des capsules were in place (normal values in ml/g/min, mean +/- sd: 0.93 +/- .12 laterally and 1.15 +/- .11 medially, decreasing to 0.25 +/- .07 and 0.24 +/- ... | 1986 | 3797420 |
| a case of brainstem encephalitis with ct scan abnormality mimicking fisher syndrome. | a 7-year-old boy with brainstem encephalitis is described. he was drowsy in the acute phase. csf showed pleocytosis without elevated protein. eeg showed diffuse slow wave activity during wakefulness. ct scan disclosed a low density abnormality in the basal ganglia area, which disappeared as the patient recovered. the clinical signs, ct scan abnormality and eeg findings suggest that this case is not a variant of the guillain-barré syndrome but is brainstem encephalitis mimicking fisher syndrome. | 1986 | 3799923 |
| teratogenic potential of the mycotoxin, citreoviridin, in rats. | citreoviridin produced by the fungus penicillium citreo-viride was administered by gavage to groups of 9-16 pregnant fisher 344 rats either on days 8-11 (group a) or on days 12-15 (group b) of gestation. doses of 0, 5, 10 or 15 mg/kg body weight were given daily in a constant volume of 1 ml/kg body weight in dimethylsulphoxide. six rats in each high-dose group died during the dosing period. compared with control groups, mean daily feed consumption was significantly reduced in the 10- and 15-mg/k ... | 1986 | 3804134 |
| carbonic anhydrase inhibition and cell volume regulation in necturus gallbladder. | gallbladder epithelial cells transport salt and water isotonically as the renal proximal tubule. the cells also have the property of regulating their cell volume in response to osmotic stress (fisher et al. 1981, persson & spring 1982, fisher & spring 1984, foskett & spring 1985). the volume-regulating phenomenon is the result of a balance between cell uptake of salt and water at the luminal membrane and exit at the basolateral membrane. different properties regarding volume regulatory increase ... | 1986 | 3811979 |
| black adolescents: a descriptive study of their self-concepts and academic achievement. | this study was designed to determine the relationships among global self-concept, self-concept of academic ability, and academic achievement of black american adolescents. the subjects were 211 tenth-grade students in five public high schools in the pacific northwest school district who volunteered to participate in the study. global self-concept was measured by the coopersmith self-esteem inventory (sei), self-concept of academic ability by the brookover self-concept of ability (general) scale, ... | 1986 | 3812075 |
| unbalanced repeated-measures models with structured covariance matrices. | the question of how to analyze unbalanced or incomplete repeated-measures data is a common problem facing analysts. we address this problem through maximum likelihood analysis using a general linear model for expected responses and arbitrary structural models for the within-subject covariances. models that can be fit include standard univariate and multivariate models with incomplete data, random-effects models, and models with time-series and factor-analytic error structures. we describe newton ... | 2013 | 3814725 |
| ethanol and aging effects on movement initiation can be dissociated from general behavioral impairment using a high-speed lever-release task in rats. | an animal model of human reaction time was used to assess the effects of ethanol on reactive capacity (rc) as a function of age. three doses of ethanol (0.5, 1.0 & 1.5 g/kg of 20% v/v, i.p.) were confirmed by gas chromatographic analysis of blood samples taken immediately following every behavioral test. fisher 344 rats were trained to use their forepaws to hold down a lever until the onset of a buzzer and light that signalled impending foot shock, which occurred within 200-1000 msec of the stim ... | 1987 | 3828002 |
| co-carcinogenic effects of several korean foods on gastric cancer induced by n-methyl-n'-nitro-n-nitrosoguanidine in rats. | in study i, 48 aci and fisher inbred rats were given mnng 100 micrograms/ml, with or without 1 per cent or 3 per cent red pepper diet; in study ii, 164 sprague-dawley rats given mnng 100 micrograms/ml, with or without 5 per cent or 10 per cent nacl; in study iii, 181 wistar rats given mnng 83 micrograms/ml with or without maejoo 10 gm per cent/diet; in study iv, 78 wistar rats given mnng 83 micrograms/ml with or without ginseng extract 150 micrograms/ml; in study v, 120 wistar rats given mnng 83 ... | 1985 | 3831496 |
| maximum shannon information content of diagnostic medical testing. including application to multiple non-independent tests. | the increase in shannon information available from a diagnostic test associated with grading of the test results into many outcomes, rather than simply positive or negative, was examined to determine its upper limit as the number of test outcomes is increased indefinitely. numerical methods were employed to find the optimal locations of outcome boundaries when a single normally distributed test variable is classified into 2, 3, 4, 5, 6, 8, 14, or 20 outcome categories. in each case shannon infor ... | 2013 | 3831639 |
| intravenous self-administration of ethanol and acetaldehyde by rats. | fisher strain rats were allowed to self-administer 2, 6, and 18 microm/kg/infusion of ethanol and acetaldehyde into the jugular vein for 22 to 28 days. thirty-three percent of the rats self-administered 18 microm/kg/infusion of ethanol. thirty-three, 40, and 33 percent of the rats initiated self-administration of 2, 6, and 18 microm/kg/infusion of acetaldehyde, respectively. it is suggested that acetaldehyde may possess stronger reinforcing effects than ethanol in intravenous self-administration ... | 1985 | 3832687 |
| a fortran program for testing trend and homogeneity in proportions. | a fortran program is provided for testing linear trend and homogeneity in proportions. trend is evaluated by the cochran-armitage method and homogeneity is tested by an overall x2 test as well by multiple pairwise comparisons by the fisher-irwin exact method. the program should be easy to implement on any size of computer with a fortran compiler. | 1985 | 3839740 |
| distinctive-feature analyses of the speech of deaf children. | 22 children aged 8.5 through 15.5 yrs with htls greater than or equal to 90 db in the better ear spoke a carrier phrase before each of 41 monosyllables containing each an initial and a final consonant (23 consonants were represented). each s repeated the 41-word list 10 times. speech samples were recorded simultaneously but independently in audio-only and in audio-visual modes, and transcribed by 3 judges using each mode separately. percent correct speaker-subjects' utterances of target consonan ... | 1985 | 3842843 |
| planning a cohort or case-control study with allowance for cost and test power. | this paper deals with balanced and unbalanced allocation designs in cohort and case-control studies. it focuses on: determination of the equal sample size design given the relative risk, r, of disease, the incidence of disease among the nonexposed group or the prevalence of exposure to risk factor, p1, type i and ii errors alpha, beta; estimation of the unequal allocation designs that either maximize the test power subject to fixed total cost or minimize the total study expenditure subject to pr ... | 1985 | 3850016 |
| functional analysis of mononuclear cells infiltrating into tumors: differential cytotoxicity of mononuclear cells from tumors of immune and nonimmune rats. | a million syngeneic gliosarcoma (t-9) cells injected subcutaneously are sufficient to kill fisher rats within 2 mo. fisher rats became resistant to t-9 cells by surgical removal of the implanted tumor and repeated immunization with mmc-treated t-9 cells. histopathologic studies revealed massive accumulation of mononuclear cells in tumor tissues of immune rats that were rejecting syngeneic t-9 tumors, whereas very few mononuclear cells were found in tumor tissues of nonimmune rats. cell populatio ... | 1985 | 3855260 |
| [regional blood flow of experimental brain tumors with special reference to effects of chemotherapy and radiotherapy]. | regional blood flow and capillary permeability in the experimental brain tumors and their surrounding brain tissue of rats were measured with quantitative 14c-antipyrine and 14c-alpha-aminoisobutyric acid (aib) autoradiographic method. the pharmacokinetic implications with respect to drug delivery to tumor tissue and the effect of ionizing irradiation were discussed in these physiological measurement. a suspension of 1 x 10(4) rat glioma cells (e239 rg 12) was stereotactically implanted into the ... | 1985 | 3860212 |
| a monoclonal antibody (gf 22.1) detecting different patterns of hla class i cross-reactivities at different dilutions. | a murine cytotoxic monoclonal antibody (gf 22.1) was produced by balb/c immunization with gra human lymphoblastoid cells. hla-a, b and c blanketing and sds-page analysis of the immunoprecipitate demonstrated mhc class i structures as the targets. cytotoxic assays were performed with peripheral blood lymphocytes from 84 unrelated donors and from members of 15 families at different antibody dilutions. statistical analysis was performed by fisher test on each dilution separately and by mann-whitney ... | 1985 | 3863262 |
| [the importance of hla antigens in alcoholic cirrhosis]. | the existence of a relationship between hla and the possibility of the development of an alcoholic cirrhosis is researched in this paper. this work was done from 1982 to 1984, by the staff of four clinics of the medicine school of the university of uruguay. we studied 47 alcoholics with portal cirrhosis, 19 non-cirrhotic alcoholics and 250 healthy nonalcoholic controls. we confirmed with liver biopsy the cirrhosis in the first group and in the second, liver biopsy was performed in order to assur ... | 1985 | 3869871 |
| cerebral atrophy in patients on long-term regular hemodialysis treatment. | the presence of cerebral atrophy in the form of cortical damage (cortical atrophy) or subcortical damage (enlargement of ventricular cavities) was explored by computed tomography (ct) scans in 30 patients maintained on regular hemodialysis treatment (rdt) for not less than 10 years, and less than 50 years of age. whereas a group of 50 normal subjects of the same age, used as control, gave no evidence of cerebral atrophy, 46.6% of the patients maintained on rdt showed cortical atrophy, evenly dif ... | 1985 | 3872759 |
| effect of age on fever and acute-phase response of rats to endotoxin and salmonella typhimurium. | age-related effects on endogenous pyrogen-mediated febrile and acute-phase responses to endotoxin and salmonella typhimurium challenge were investigated in young adult and aged fisher 344 rats. after injection of endotoxin, the febrile response over 6 h and the fall in plasma iron and zinc after 6 h were determined in 14 young adult and 14 aged rats in their thermoneutral zone (26 degrees c) and in 14 young adult and 14 aged rats maintained in a cold environment (15 degrees c). although at 26 de ... | 1985 | 3880718 |
| penetrating corneal transplantation in the inbred rat: a new model. | a model of orthotopic penetrating keratoplasty has been developed in the inbred rat using both avascular and prevascularized recipient beds. the surgical procedure is conventional and can be achieved with standard instrumentation. isografts into avascular recipient beds (fisher 344 into fisher 344 strain combination) were successful and survived indefinitely with excellent corneal function judged either visually by clarity and lack of oedema, or histologically at autopsy. allografts into avascul ... | 1985 | 3881365 |
| [the concept of cerebral lacunae from 1838 to the present]. | the term lacunae was first used by dechambre (1838) referring to small cavities developed during the process of resorption within cerebral softenings. some years later, lacunae was applied by durand-fardel (1843) to small cavities located in the basal ganglia and hypothetically attributed to old, healed cerebral softenings. durand-fardel (1842, 1854) described "l'état criblé" as many round small holes ("criblures") always containing a patient blood vessel and located in the hemispheric white mat ... | 1985 | 3885361 |
| cholecystokinetic cholecystography. | a prospective clinical trial of 100 patients receiving either intramuscular ceruletide or a fatty meal to contract the gallbladder after oral cholecystography is described. the percentage reduction of the gallbladder area after 30 min of stimulation was not significantly greater with ceruletide (49%) than with a fatty meal (44%) (t-test: p greater than 0.3). ceruletide caused significantly more adverse reactions than a fatty meal (fisher test, p less than 0.01). the diagnostic value of routine c ... | 1985 | 3888766 |
| prodynorphin immunoreactivity is located in different neurons than proenkephalin immunoreactivity in the cerebral cortex of rats. | reported here is a description of the distribution and cellular morphology of neurons containing dynorphin b immunoreactivity (ir) and a comparison with cells containing bovine adrenal medullary peptide ir in the cerebral cortex of colchicine treated rats. dynorphin b-ir was found in bipolar and multipolar cells in neocortical layers ii-iii and v-vi and in pyramidal and polymorph cells in olfactory cortical layers ii and iii. in the hippocampus, dynorphin b-ir was found in dentate granule cells ... | 1985 | 3889694 |
| restriction of gut-derived endotoxin impairs dna synthesis for liver regeneration. | the influence of restricting gut-derived endotoxin availability on liver regeneration after partial hepatectomy was evaluated. partial hepatectomy was performed by 67% liver resection of ether-anesthetized rats. liver regeneration was quantified after partial hepatectomy by [3h]thymidine incorporation into hepatic dna; endotoxemia due to absorption of endogenous endotoxin from the gut into the portal circulation was determined by qualitative lysate assay of perchloric acid-extracted plasma sampl ... | 1985 | 3904484 |
| [levels of inorganic and organic substances in the femur of fisher rats treated with derivatives of vitamin d]. | 1985 | 3917131 | |
| time course of induction of prolactin-secreting pituitary tumors with diethylstilbestrol in male rats: response of tuberoinfundibular dopaminergic neurons. | 3,4-dihydroxyphenylalanine (dopa) accumulation and dopamine (da) and noradrenaline levels were measured in the median eminence (me) of fisher 344-derived inbred male rats. these animals had been treated with silastic capsules containing 8-9 mg diethylstilbestrol (des) or with empty capsules for 3, 7, 14, or 30 days and had the pellets removed 22 days before killing. in an additional group of rats, the des pellets were continuously present until killing. blood was collected before treatment was s ... | 1985 | 3917247 |
| the efficacy of total parenteral nutrition in malnourished tumor-bearing rats. | the current study was designed to compare the efficacy of total parenteral nutrition (tpn), provided either before or after tumor removal, in replenishing protein stores in the malnourished tumor-bearing (tb) host. fisher 344 rats bearing a transplantable methylcholanthrene (mca)-induced sarcoma were used. after the animals were cachectic from their tumor, a central venous catheter was inserted. at the time of catheter insertion, the animals were randomized into two groups. group i rats had the ... | 1985 | 3918782 |
| monoclonal antibodies prepared against the major drosophila nuclear matrix-pore complex-lamina glycoprotein bind specifically to the nuclear envelope in situ. | a high molecular weight glycoprotein found associated with a nuclear matrix-pore complex-lamina (nmpcl) preparation obtained from drosophila melanogaster embryos has been shown by in vitro analyses to be largely confined to this subcellular fraction. in contrast with several of the nmpcl proteins, this glycoprotein remains completely insoluble after treatment with 5 m urea. it has, therefore, been possible to separate the glycoprotein from other nmpcl components by differential urea extraction. ... | 1985 | 3919018 |
| presence of high affinity dopamine receptors in estrone-induced, prolactin-secreting rat pituitary adenomas: a model for human prolactinomas. | adenomatous cells obtained from a pituitary tumor induced in fisher 344/lis rats by the subcutaneous implantation of estrone (e1) were found to secrete large amounts of prolactin (prl). the secretion of prl was stimulated by thyrotropin-releasing hormone (trh) and low concentrations of dopamine (da), while micromolar concentrations of da were inhibitory. high affinity binding sites for 3h-spiroperidol (3h-spir) were found to be present on the cells and to conform to the criteria of dopaminergic ... | 1985 | 3920132 |
| polylactosamine glycosylation on human fetal placental fibronectin weakens the binding affinity of fibronectin to gelatin. | gelatin-binding chymotryptic fragments from placental fibronectin contain polylactosamine carbohydrates (zhu, b.c.r., fisher, s.r., pande, h., calaycay, j. shively, j.e., and laine, r.a. (1984) j. biol. chem. 259, 3962-3970). we have separated polylactosamine-containing gelatin-binding fragments of placental fibronectin from their counterparts containing smaller "complex" n-linked saccharides using sephadex g-200 gel permeation chromatography. the peptide portions of both fragments have similar ... | 1985 | 3920213 |
| biochemical and clinical evaluation of a new cellulose diacetate secondary filter for cascade filtration. | we have performed 24 cascade filtration treatments in 8 patients with hyperviscosity syndrome (2 cases), essential mixed cryoglobulinemia, post-hepatitic cryoglobulinemia, sjogrens disease, rheumatoid vasculitis, miller-fisher syndrome and chronic dysimmune polyneuropathy. new cellulose diacetate filters were employed, giving a satisfactory performance. at 1.5 l plasma treatment, the rejection rate for macromolecular plasma components was close to 90%, whereas albumin recovery was close to 70%. ... | 1985 | 3921467 |
| [chromosome analysis of female baboons following treatment with sts 557 and levonorgestrel]. | adult, female baboons (papio hamadryas) were administered orally once 18 h p.c., either 1.6 mg sts 557 (17 alpha-cyanomethyl-17 beta-hydroxy-estra-4;9(10)-dien-3-one) or 1.6 mg levonorgestrel. investigations of the bone-marrow cells of these animals showed, compared to untreated controls, no signs of increased chromosome aberrations caused by the substances. the relative frequency of chromosome aberrations were estimated for controls: sts 557: levonorgestrel with 0.60 +/- 0.35 : 0.55 +/- 0.39 : ... | 1985 | 3922162 |
| miller-fisher syndrome (guillain-barré syndrome with ophthalmoplegia) during treatment with gold salts in a patient with rheumatoid arthritis. | 1985 | 3925959 | |
| delayed enzyme expression: a defect of aging rat gut. | to evaluate the effect of aging upon the small intestine, the distribution, content, and concentration of epithelial cell enzymes at different levels along the crypt-villus column were measured in aging and young adult, male, fisher 344 rats. specific activities of sucrase, maltase, lactase, and adenosine deaminase in mucosal homogenates were lower in the upper intestines of aging than in young animals, whereas the specific activity and content of thymidine kinase was higher. enzyme activities w ... | 1985 | 3930340 |
| the effect of parenteral nutrition on gastrointestinal immunity. the importance of enteral stimulation. | secretory iga (s-iga), an immunoglobulin present in secretions, prevents the adherence of bacteria to mucosal cells and is the principle component of the gut mucosal defense system. the purpose of this study was to determine whether the route of nutrient administration affects s-iga. twenty-five female fisher rats were randomized into three groups. groups i and ii were fed an isonitrogenous, isocaloric standard hyperalimentation solution, group i intravenously and group ii via a gastrostomy. gro ... | 1985 | 3935061 |
| residuals in multiple regression analysis. | an examination of residuals can be used as a technique to determine the best model for use in multiple-regression analysis. in addition to r2 and the fisher f ratio, a complete analysis of residuals has been used by statisticians for many years to estimate bias and to choose the best equation to fit physicochemical as well as biological and psychosociological data. however, residual analysis has seldom appeared in studies in pharmaceutics, pharmacology, or medicinal chemistry. this report gives ... | 1985 | 3935772 |
| maternal epilepsy and birth defects: a case-control study in the italian multicentric registry of birth defects (ipimc). | a case control study on the association between maternal epilepsy, anticonvulsants use during pregnancy and birth defects was carried out in the italian multicentric registry of birth defects (ipimc). in the period 1980-1983, 7,607 malformed babies out of 439,717 total births (still + live) were registered. fourty-one malformed babies with maternal epilepsy were identified (5.39 x 1,000). the overall relative risk of having a malformed baby among pregnant epileptic women was 1.87. spina bifida, ... | 1985 | 3939491 |
| alterations in calmodulin levels in tissues from aged animals. | we measured the levels of calmodulin in brain tissue as well as in other tissues by a specific radioimmunoassay. fisher-344 rats with ages of 3, 13, 23, and 29 months were used. ir-calmodulin levels were reduced in the cortex, striatum, and anterior pituitary but not in the hypothalamus (although there was a tendency for reduction in the latter tissue). no significant decreases in ir-calmodulin were observed in gastrocnemius, kidney, or heart of the oldest group of rats, and, in fact, the levels ... | 1986 | 3941252 |
| investigations into parametric analysis of data from in vivo micronucleus assays by comparison with non-parametric methods. | data from micronucleus assays of 6 compounds were analysed by 3 non-parametric and 3 parametric methods. two of the latter involved transformation of the data so several transformation strategies were investigated. it was concluded that the non-parametric kolmogorov-smirnov two-sample test was the most reliable method of analysis. none of the parametric solutions was entirely satisfactory. the bayesian solution to the behrens-fisher problem of normal distributions with differing variances was an ... | 2007 | 3941664 |
| acetylcholine, aging and anatomy: differential effects in the hippocampus. | the response to acetylcholine (ach) administered microiontophoretically was determined for single units in ca1 and ca3-4 areas of the hippocampi of both young (3-5 months) and old (24-26 months) fisher 344 rats. single units in ca1 showed a greater response to ach (20 na) than single units in ca3-4 in young and in old rats. however, the response to ach in single units of young rats was significantly greater than in single units of old rats. baseline firing rates in old rats were lower than those ... | 1986 | 3942863 |
| acute bilateral ophthalmoplegia: 60 cases. | of 60 patients with acute bilateral ophthalmoparesis, the cause was within the brainstem in 18 (pretectal infarct, phenytoin toxicity, and wernicke's syndrome), in cranial nerves in 26 (guillain-barré or fisher syndrome, tuberculous meningitis), within the cavernous sinuses in 8 (tumors or infection), and at the myoneural junction in 8 (myasthenia or botulism). | 1986 | 3945401 |
| perineal effects of postoperative treatment for adenocarcinoma of the rectum. | nine (4%) first recurrences that involved the perineum were identified in a randomized study of 202 patients treated by no further therapy, chemotherapy only, radiotherapy only, combined radiotherapy and chemotherapy, following complete surgical excision of adenocarcinoma of the rectum. six of these were in unirradiated patients and in two of the three irradiated patients the perineum was included in the treatment volume. eight of the nine patients were male and all nine had received abdominoper ... | 1986 | 3949566 |
| human iga as a heterovalent ligand: switching from the asialoglycoprotein receptor to secretory component during transport across the rat hepatocyte. | asialoglycoproteins are taken up by the rat liver for degradation; rat polymeric iga is taken up via a separate receptor, secretory component (sc), for quantitative delivery to bile. there is negligible uptake of these ligands by the converse receptor, and only a low level of missorting of ligands to opposite destinations. the two pathways are not cross-inhibitable and operate independently (schiff, j.m., m. m. fisher, and b. j. underdown, 1984, j. cell biol., 98:79-89). we report here that when ... | 1986 | 3949883 |
| decremental vasopressin release after repeated stimulation of superfused neurohypophyses of fisher 344 rats of different ages. | we studied the effect of aging on the decline in vasopressin (vp) release from the rat neurohypophyses (nh) as evoked by repeated stimuli with high k+ (56 mm) locke's solution in vitro. isolated nhs, without pars intermedia, of 2-, 12- and 30-month-old male fisher 344 rats arbitrarily labeled as young, adult, and old were individually superfused with synthetic medium tc 199. following the initial traumatic release, the glands were stimulated three times for 10 min each with recovery periods of 3 ... | 1986 | 3950338 |
| sylvatic trichinosis in ontario, canada. | samples of muscle from 4,773 specimens of 18 species of wild mammals from ontario were examined for trichinella. one of 12 mink (mustela vison), 83 of 1,821 fisher (martes pennanti) and 68 of 1,980 marten (martes americana) had t. spiralis. prevalences of infections by trichinella were determined for fisher and marten from the algonquin region, over a 10-yr period. prevalences ranged from 0.9-9.2% in fisher and 1.3-8.7% in marten indicating that the parasite is well-established in the region. pr ... | 1986 | 3951060 |
| reduction of motor behavioral deficits in senescent animals via chronic prolactin administration. ii. non-stereotypic behaviors. | the effects of chronic prolactin administration on three non-stereotypic psychomotor behaviors (inclined screen performance, rod walking and wire hanging) were examined in senescent (24 month) fisher 344 rats. prolactin (150 ng/hr) was administered for 7 days via alzet minipumps to rats which had been pretested on the three tasks. the animals were tested on days 4 and 7 following the implants and the pumps were removed after testing on day 7. in order to assess the persistence of any prolactin e ... | 1986 | 3951657 |
| abnormal cytodifferentiation in leiomyosarcomas induced with injection of nickel subsulfide into skeletal muscles of rats. light and electron microscopic observations. | seven leiomyosarcomas, induced individually with a single injection of nickel subsulfide (0.4 mg) into skeletal muscles of fisher 344 male rats were studied with the light and with the electron microscope. the tumors consisted of fibroblast-like cells lacking the cytoplasmic filaments found in normal maturing and mature smooth muscle, and of cells in which the appearance of these filaments occurred in the following sequence: first, actin filaments in concomitance with intermediate filaments; sec ... | 1986 | 3963732 |
| abscence of cns lesion in autopsied patients with miller-fisher syndrome. | 1985 | 3966876 | |
| the effects of prolactin on rat testicular steroidogenic enzyme activities. | to investigate whether hyperprolactinemia directly affects rat testicular steroidogenesis, we examined the effects of prolactin (prl) on microsomal 3 beta-hydroxysteroid dehydrogenase (3 beta-hsd) 17-hydroxylase (17-oh), 17,20-desmolase (17,20-d), 17-ketosteroid reductase (17-ksr) and aromatase enzyme activities. adult hypophysectomized, gonadotropin-treated fisher rats were rendered hyperprolactinemic by isografting pituitaries under the kidney capsule. the controls received skeletal muscle. al ... | 1985 | 3967847 |
| effect of surgery on tumor-induced accelerated coagulation in a rat carcinoma. | accelerated coagulation detected by thromboelastography has been reported in early stages of tumor growth. the present investigation was conducted to determine the changes in tumor-induced accelerated coagulation following complete and partial resection of the tumor. male fisher rats were divided into four groups: (1) control, (2) tumor-bearing rats, (3) complete resection, (4) partial resection. in groups 2, 3, and 4 a 2-mm3 piece of squamous cell carcinoma (nci 11095) was implanted subcutaneou ... | 1985 | 3968872 |
| inhibitory effects of secretin on gastrin-stimulated rat colon neoplasms. | a study was done to determine if continuous administration of exogenous secretin would inhibit the trophic effect of elevated endogenous gastrin on colon neoplasms in rats. colon tumors were induced in 37 fisher rats by subcutaneous injection of 1,2-symdimethylhydrazine, 20 mg/kg, weekly for 18 weeks. elevation of endogenous gastrin was achieved by antral exclusion surgery. control rats received a sham operation. subcutaneous osmotic minipumps delivered 35.5 u/kg/day of secretin for 7 days befor ... | 1985 | 3971292 |
| neurological findings in miller-fisher syndrome. | 1985 | 3973632 | |
| approaches to prostatic cancer chemotherapy using the dunning r3327h prostatic adenocarcinoma. | androgen-responsive cells: to determine if testosterone or dihydrotestosterone is the main trophic hormone of prostatic adenocarcinoma, we have treated dunning r3327h prostatic adenocarcinoma-bearing rats with 6-methylene progesterone, which blocks conversion of testosterone to dihydrotestosterone. copenhagen-fisher rats were treated with steroid (20 mg/kg daily) immediately following implantation of tumor and thereafter for 117 days. there was a 92% inhibition of growth of tumors and a lesser e ... | 1985 | 3975175 |
| effects of phenobarbital and skf-525a on in vitro hepatic metabolism of verapamil and nifedipine. | both verapamil and nifedipine are first-generation calcium-entry antagonist drugs which are eliminated by hepatic metabolism. to evaluate the effects of enzyme induction and suppression on the biotransformation of these compounds, liver homogenate fractions were prepared from male fisher (f344) rats, which were either untreated, or injected intraperitoneally with phenobarbital or with skf-525a prior to sacrifice. known concentrations of verapamil or nifedipine were incubated with the 9,000 g sup ... | 1985 | 3975261 |
| [the miller fisher syndrome: ophthalmoplegia, ataxia and areflexia]. | 2014 | 3976062 | |
| lesions of articular, sternal and growth plate cartilage in rats. | degenerative osteoarthritis was observed in the femur and sternum in specific pathogen free fisher 344 rats at 13 and 19 months of age. histological changes consisted of degeneration of the matrix and erosion in the articular cartilage of the femur. in the sternal cartilage, degeneration and necrosis of the matrix, formation of cysts, and cleft-like fractures were observed. in addition, degeneration of the matrix, appearance of eosinophilic streaking, and necrosis and fissure between the growth ... | 1985 | 3976132 |
| [comparative quantitative assessment of a carcinogenic effect taking intercurrent mortality into account]. | the paper discusses the advantages offered by the statistical evaluation of experimental carcinogenic effect with due regard to mortality from concomitant pathology. the method used complex tables of contingents and analysis was carried out separately in 3 groups of tumors--independent of mortality, fatal and incidental ones. the method was compared with standard procedures which do not take care of the said mortality rate (table of contingents 2 x 2 and precise procedure of fisher). the data on ... | 1985 | 3976212 |
| prediction of developmental attainments of institutionalized mentally retarded children. | two regression equations using chronological age and either iq or the fisher and zeaman k score were developed to predict developmental record ratings of institutionalized mentally retarded children over a 2-year interval (n = 200), a 4-year interval (n = 165), and an 8-year interval (n = 95). although the correlations between predicted and obtained scores for both equations were quite high even over an 8-year interval, analysis of mean differences revealed that the equation using iq yielded mor ... | 1985 | 3976735 |
| reduced calcium uptake by rat brain mitochondria and synaptosomes in response to aging. | synaptosomes were isolated from cerebral cortex of 3-, 18- and 24-month-old male, fisher 344 rats and 45ca2+ uptake was measured at 1, 3, 5, 15 and 30 s time periods following 65 mm kcl depolarization. identical experiments were performed in which 5 mm kcl was added to examine age-related changes in resting 45ca2+ accumulation by synaptosomes. both 'fast-' and 'slow-phase' voltage-dependent 45ca2+ uptake were significantly reduced in synaptosomes from 18- and 24- vs 3-month-old rats. no age-rela ... | 1985 | 3978439 |
| measles outbreak in a pediatric practice: airborne transmission in an office setting. | in february 1981, a measles outbreak occurred in a pediatric practice in dekalb county, ga. the source case, a 12-year-old boy vaccinated against measles at 11 1/2 months of age, was in the office for one hour on the second day of rash, primarily in a single examining room. on examination, he was noted to be coughing vigorously. seven secondary cases of measles occurred due to exposure in the office. four children had transient contact with the source patient as he entered or exited through the ... | 1985 | 3982900 |
| effects of factors derived from a tumor clonal cell line on dna synthesis of transformed and non transformed cells. | conditioned medium from neoplastic thyroid cell cultures, extracts of tumors developed by identical cells in isogeneic fisher 344 rats and serum from those tumor-bearing animals, were tested in pulse thymidine labelled experiments on a transformed and two non transformed cell lines. tumor extract and conditioned medium inhibited dna synthesis. tumor-bearing rat serum increased dna synthesis in a cerebellar transformed cell line, but no in chick embryo fibroblasts or in aorta non transformed cell ... | 1985 | 3986917 |
| image analysis of gfa-positive astrocytes from adolescence to senescence. | smears of fresh rat brain tissue combined with immunohistochemistry using antiserum to glial fibrillary acidic protein (gfa) were used to visualize individual astrocytes in different cortical regions of rats ranging in age from 1 to 30 months. by computerized image analysis, the cell area and the cell perimeter were determined. using 4-month-old male sprague-dawley rats, it was found that gfa-positive astrocytes from cerebellum and hippocampus were significantly larger, both in terms of cell are ... | 1985 | 3987847 |
| effects of chronic bromocriptine treatment of an estrone-induced, prolactin-secreting rat pituitary adenoma. | bromocriptine (brom), a dopamine (da) agonist, is commonly and successfully used for long-term treatment of human prolactinomas. we have studied the effects of chronic brom administration to female 344 fisher/lis rats bearing an estrone-induced, prolactin (prl)-secreting pituitary tumor recently characterized as a model for human prolactinoma. the animals were injected twice daily with brom (2.5 mg/kg) or with diluent. after 1 month of treatment, the animals were sacrificed, and plasma collected ... | 1985 | 3997065 |
| a macrophage-mediated factor that increases the high energy phosphate content of skeletal muscle. | a marked cellular infiltrate accompanies wounding. the phagocytic and bacteriocidal activities of this infiltrate require increased substrate and o2 consumption. this rapid utilization of available oxygen and substrates could jeopardize an already compromised resident cellular component of a wound. recent studies have demonstrated macrophage-mediated cell stimulatory agents which induce proliferation of nonlymphoid mesenchymal cells. this study was designed to examine macrophage-resident tissue ... | 1985 | 3999732 |
| growth-depressing effects of alcohol and nicotine in two strains of rats. | inbred buffalo and fisher rats were submitted to daily treatment with alcohol and nicotine for a period of 6 months. alcohol treatment was pre- and postnatal, nicotine treatment postnatal only. all parameters of bone length and weight were depressed in both experiments in spite of the continuous growth of the rats. although the level of depression was greater in some areas than in others, a clear target area applicable to both sexes and strains could not be found. fisher and buffalo females tole ... | 1985 | 4003023 |
| method for estimating right ventricular volume by planes applicable to cross-sectional echocardiography: correlation with angiographic formulas. | right ventricular (rv) volumes determined by echocardiography were compared with those measured using established angiographic formulas. rv cast displacement volumes were first correlated with data derived from radiographic images of the casts corresponding to standard angiographic rv views. four established angiographic formulas (ferlinz, boak, fisher and thilenius) correlated well with cast volume, with the corrected prism method of fisher showing a best fit (r = 0.98, y = 1.1 + 0.9 x, standar ... | 1985 | 4003302 |
| some goodness-of-fit methods for the poisson plus added zeros distribution. | methods for making inferences about the poisson plus added zeros distribution and the truncated poisson distribution are presented and illustrated with bacteriological data. some of the methods are designed for testing the compatibility of the zero frequency with the poisson distribution, whereas others are given for testing the goodness of fit for the truncated poisson. in particular, a modified form of the fisher index of dispersion is presented which is suitable for the truncated case. it is ... | 1985 | 4004245 |
| typology of male-to-female transsexualism. | this study tested a prediction derived from the hypothesis that asexual and bisexual transsexualism are actually subtypes of heterosexual transsexualism. two questionnaire scales measuring erotic attraction to males and females were administered to 163 male-to-female transsexuals. a cluster analysis of their scores divided the subjects into four groups: heterosexual, homosexual, bisexual, and asexual. fisher exact tests were used to compare the frequency with which subjects in the four clusters ... | 2014 | 4004548 |
| electrophysiologic and antiarrhythmic effects of sotalol in patients with life-threatening ventricular tachyarrhythmias. | sotalol is a unique beta-blocker that lengthens cardiac repolarization and effective refractory period (erp). its efficacy after intravenous (1.5 mg/kg) and oral (160 to 480 mg bid) administration was therefore evaluated in 37 patients with refractory recurrent ventricular tachycardia/fibrillation (vt/vf). thirty-five patients, 33 with inducible vt/vf, underwent electrophysiologic testing. intravenous sotalol lengthened the erp in the atrium (+24.6%, p less than .01), atrioventricular node (+24. ... | 1985 | 4017207 |
| nonparametric methods. clinical applications. | in clinical research, "samples" are studied in order to get ideas about the characteristics of the larger populations from which the samples are taken. population characteristics are called parameters (the population mean and standard deviation are examples). parametric statistical methods are those that require estimates of parameters and assumptions about the source populations. familiar examples of parametric methods are the t test, analysis of variance, and pearson's correlation coefficient. ... | 2011 | 4017399 |
| macrophage interaction with skeletal muscle: a potential role of macrophages in determining the energy state of healing wounds. | a decrease in atp and creatine phosphate (cp) is characteristic of local injury to skeletal muscle. recent data have suggested adequate potential for high-energy phosphate production in the wounded tissue. thus, an adequate explanation for the deficit in the high-energy tissue content in wounds was lacking. since the wound has multiple components (muscle + cellular infiltrate), the tissue content represents the summation of these components. therefore, a technique to separate these components wa ... | 1985 | 4020909 |
| hypersecretion of gastric acid in a representative finnish family sample. | to evaluate the family behaviour of acid secretion and particularly of 'hypersecretion', we have examined by pentagastrin test and direct vision gastric biopsy 342 subjects with a normal mucosa or superficial gastritis of the body mucosa, collected from a large family sample of the finnish population. acid output (ao) was expressed in terms of fat-free body weight (ffb), which eliminates the sex factor found by other expressions of ao. subjects with values above 1.0 mmol/h/ffb were considered 'h ... | 1985 | 4023613 |
| correlation of human bladder tumor recurrence with changes in clonogenicity of urothelial cells. | over a 2-year period 340 cystoscopies were performed on 174 patients (126 men and 48 women) followed up for previously treated transitional cell tumor of the bladder or new cases suspected of having bladder tumor. bladder washings taken at cystoscopy in 66% yielded cells for clonogenic assay. patients with transitional cell tumors had an average clonogenic index (ci) of 14 (+/- 5) colonies per 10(5) viable urothelial cells, whereas previously tumorous patients with tumor-free bladders had an ave ... | 1985 | 4027894 |
| thyroid adenoma and ovarian luteinization in an aged fisher (martes pennanti). | 1985 | 4032637 | |
| in vivo and in vitro antiestrogenic action of 3-hydroxytamoxifen, tamoxifen and 4-hydroxytamoxifen. | this study demonstrates in vivo and in vitro properties of the non-steroidal antiestrogens tamoxifen (tam), 4-oh-tamoxifen (4-oh-tam) and 3-oh-tamoxifen (k 060 e). in immature rabbit uteri 4-oh-tam and k 060 e bound to the respective estrogen receptors with a ten-fold higher affinity than tam. furthermore, k 060 e exhibited less agonistic (estrogenic) but higher antagonistic (antiestrogenic) activity in the immature rat uterus than tam and 4-oh-tam (change of uterine weight). the ratio of agonis ... | 1985 | 4043181 |
| electroencephalographic cartography. ii. by means of statistical group studies-activation by visual attention. | 10 male volunteers, right-handers, mean age 30.4 years, were recorded in four successive sequences: under 'eyes closed' conditions, right and then left hemisphere, followed by an 'eyes open' situation with visual attention fixed on a cartoon, right and then left hemisphere recordings. each eeg recording was made simultaneously over 16 eeg channels for each hemisphere, according to a protocol previously described as well as fourier analysis and eeg mapping on a minicomputer (hp 5451 c, hp 1000). ... | 2014 | 4047376 |
| [schizophrenically disordered time perception and its modification by neuroleptics]. | the authors deal with the question as to whether the target symptom "disturbed time perception" is to be considered a basic schizophrenic symptom and whether therapeutical (neuroleptic) control possibilities exist. 135 schizophreniacs have given statistical evidence (intensity quotient, wilcoxon comparison, hotelling-pabst test, exact probability test according to fisher/yates) that the disturbed time perception of schizophreniacs is accessible by a differentiated neuroleptic therapy but is not ... | 1985 | 4048304 |
| long-term consequences of cis-platinum-induced renal injury: a structural and functional study. | previous studies have shown that a single dose of the antitumor drug, cis-platinum, causes renal cyst formation in rats 1-6 months after drug injection. this observation led to a further evaluation of the long-term effects of cis-platinum on the kidney of the rat. fisher 344 rats (n = 13) were given either a single intraperitoneal injection of cis-platinum (6 mg/kg body weight) or saline (control) and 15 months later renal function and pathology were assessed. the glomerular filtration rate and ... | 1985 | 4061878 |
| post-partum antibody-dependent cell-mediated immunity in the rat following perinatal exposure to iodine-131. | a study was recently completed which indicated the first generation of adult rats that had been exposed perinatally to iodine-131 possessed peripheral blood lymphoid-cells capable of expressing cytotoxicity towards cultured small bowel adenocarcinoma target cells, i.e., active antitumor cell-mediated immunity (cmi). the results gathered during the current investigation suggest that such animals similarly express anti-tumor antibody-dependent cell-mediated immunity (adcc). the animal model employ ... | 1985 | 4062256 |
| arousal deficit shown in aged rat's quantitative eeg and ameliorative action of pramiracetam compared to piracetam. | the basal eeg profile of the aged fisher-344 rat was consistently different from that of the young rat, showing dominant high voltage slow-wave components. these slow waves were present in both the frontal cerebral cortex and dorsal hippocampus. absent or greatly attenuated in the aged rat's hippocampal eeg was rhythmic theta activity, which was always dominant in the young awake rat's hippocampus. these eeg differences were clearly apparent only under basal test conditions, i.e., following habi ... | 1985 | 4065299 |
| a walker 256 tumor-induced osteogenic small animal model for the evaluation of [99mtc] diphosphonate radiopharmaceuticals. | a mammalian model has been developed for the in vivo evaluation of bone imaging agents. the model is based upon the quantification of a discrete, initial secondary periosteal osteogenesis induced in cortical bone immediately adjacent to an intramuscularly implanted walker 256 tumor in fisher 344 rats. evaluation of the model consists of a histopathological examination of the periosteal bone formation, biodistribution studies on 99mtc-mdp and 99mtc-hmdp commercial kit preparations, and biodistrib ... | 1985 | 4066198 |
| homozygosity in a population of variable size and mutation rate. | a formula is obtained for the probability that two genes at a single locus, sampled at random from a population at time t, are of particular types. the model assumed is a diffusion approximation to a neutral wright-fisher model in which mutation is not necessarily symmetric and the population size is a function of time. it is shown that for symmetric mutation in a population undergoing a step-function type bottleneck, homozygosity increases with decreasing population size. a formula is given for ... | 1985 | 4067439 |