Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| mandibular osteomyelitis and cervical lymphadenitis due to mycobacterium abscessus: surgical management of a pediatric cohort with a shared epidemiologic exposure. | mycobacterium abscessus has been implicated as the cause of various infections in the setting of healthcare-related "outbreaks." mandibular osteomyelitis caused by m abscessus is exceedingly rare, with only 1 patient reported in the literature. the authors describe the surgical management of 12 pediatric patients with m abscessus-related mandibular osteomyelitis and cervical lymphadenitis caused by exposure to contaminated water at a regional dental clinic. | 2017 | 28938329 |
| osteomyelitis due to multiple rare infections in a patient with idiopathic cd4 lymphocytopenia. | a 26-year-old male patient presented with features suggestive of osteomyelitis involving the entire left femur, hip joint and knee joint. culture from the debrided tissue grew acinetobacter spp. and he was treated with sensitivity based antibiotics but the symptoms did not resolve. the synovial biopsy showed multinucleated giant cells and acid fast bacilli on ziehl neelsen stain. cartridge based nucleic acid amplification test (genexpert) was negative. the mycobacteria growth indicator tube cult ... | 2017 | 28944144 |
| mycobacterium abscessus glossitis. | 2017 | 28948933 | |
| effectiveness of an ultraviolet-c disinfection system for reduction of healthcare-associated pathogens. | healthcare-associated infections caused by multidrug-resistant (mdr) pathogens are significantly associated with increased mortality and morbidity. environmental cleaning can reduce transmission of these pathogens but is often inadequate. adjunctive methods are warranted to enhance the effectiveness of disinfection particularly in hospital settings where healthcare-associated infections are of major concern. | 2017 | 28951015 |
| anti-interferon-γ autoantibody-associated disseminated mycobacterium abscessus infection mimicking parotid cancer with multiple metastases: a case report. | among the nontuberculous mycobacteria, mycobacterium abscessus is a common cause of skin, soft tissue, and bone infections. however, disseminated m. abscessus infection that mimics cancer metastasis with an underlying relatively immunocompetent condition has rarely been reported. | 2017 | 28953638 |
| mycobacterium abscessus lymphadenitis in bone marrow transplant patient. | non-tuberculous mycobacteria (ntm) are acid-fast bacteria categorized into rapidly growing and slow growing mycobacteria. ntm are more common in transplant patients who are immunocompromised. here we report the case of a post- bone marrow transplant adolescent male presenting with submandibular swelling and fever. the gland was excised and the histopathology showed chronic granulomatous inflammation. culture grew mycobacterium abscessus which was sensitive to amikacin, linezolid and clarithromyc ... | 2017 | 28955087 |
| relationship between antibiotic susceptibility and genotype in mycobacterium abscessus clinical isolates. | this study aimed to determine the antibiotic susceptibility and resistance related genotypes of mycobacterium abscessus. one hundred sixty-two clinical isolates were collected. genomic data were obtained by whole genome sequencing. single nucleotide polymorphism (snp) analysis was conducted using the ncbi genbank database and blast algorithm. the following genes were of interest: erm(41), rrl and rrs. erm(41) was further divided into 3 sequevars: erm(41)c28, erm(41)t28, and m type [erm(41) with ... | 2017 | 28959242 |
| effect of β-lactamase production and β-lactam instability on mic testing results for mycobacterium abscessus. | limited treatment options available for mycobacterium abscessus infections include the parenteral β-lactam antibiotics cefoxitin and imipenem, which show moderate in vitro activity. other β-lactam antibiotics (except meropenem) have no considerable in vitro activity, due to their rapid hydrolysis by a broad-spectrum β-lactamase (bla_mab). we here addressed the impact of β-lactamase production and β-lactam in vitro stability on m. abscessus mic results and determined the epidemiological cut-off ( ... | 2017 | 28961987 |
| non-tuberculous mycobacterium bacteraemia in a pregnant systemic lupus erythematosus (sle) patient: a case review and pooled case analysis. | non-tuberculous mycobacteria (ntm) are recognized as an important cause of human diseases and infections. it is commonly known to cause infections of the skin, soft tissue infections, and pulmonary infection as well as bacteraemia. we report a challenging case of severe mycobacterium abscessus bacteraemia in a pregnant lady with active systemic lupus erythematous (sle). a comprehensive literature review of ntm infection among sle patients was also performed, and pooled analysis of the reported c ... | 2017 | 28971307 |
| mycobacterium abscessus complex infections in children: a review. | infections in children with mycobacterium abscessus complex represent a particular challenge for clinicians. increasing incidence of these infections worldwide has necessitated focused attention to improve both diagnostic as well as treatment modalities. published medical literature was reviewed, with emphasis on material published in the past 5 years. | 2017 | 28983867 |
| mycobacterium abscessus and massiliense lung infection during macrolide treatment for bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation. | in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-sct), post-transplant lung infection is critical for their prognosis. mycobacterium abscessus complex is not fully recognized as a nontuberculous mycobacteria (ntm) pathogen of post-sct lung infection. here, we present three post-allogeneic sct patients who developed pulmonary infection caused by m. abscessus complex including m. abscessus and m. massiliense. in all three cases, macrolide antibiotics had been adminis ... | 2018 | 28988958 |
| clinical mycobacterium abscessus strain inhibits autophagy flux and promotes its growth in murine macrophages. | autophagy is known to be a vital homeostatic defense process that controls mycobacterial infection. however, the relationship between autophagy response and the virulence of mycobacterium abscessus strain uc22 has not been reported. here, we demonstrate that m. abscessus induces autophagy and inhibits autophagy flux in murine macrophages. further, the rough variant of m. abscessus, uc22 that is a highly virulent clinical isolate, significantly inhibited autophagic flux than the smooth variant of ... | 2017 | 29044406 |
| survival of pathogenic mycobacterium abscessus subsp. massiliense in acanthamoeba castellanii. | we used an amoeba model to study the intracellular growth and cytotoxicity of clinical strains of mycobacterium abscessus subsp. massiliense (mabsm) isolated from 2 patients (one with cystic fibrosis, the other one with idiopathic bronchiectasis) during the early (smooth colonies) and late stage (rough colonies) of chronic pulmonary infection. acanthamoeba castellanii were infected with mabsm (moi 100) and samples collected every 24 h for 72 h. results showed mabsm is able to survive in trophozo ... | 2018 | 29056478 |
| causative species of nontuberculous mycobacterial lung disease and comparative investigation on clinical features of mycobacterium abscessus complex disease: a retrospective analysis for two major hospitals in a subtropical region of japan. | nontuberculous mycobacteria (ntm) lung disease is increasing globally. although the etiological epidemiology of ntm is different across regions, mycobacterium avium complex (mac) is the leading cause of ntm lung disease in most countries, including mainland japan. okinawa is located in the southernmost region of japan and is the only prefecture categorized as a subtropical region in japan, it is therefore likely the etiological epidemiology of ntm lung disease is different from mainland japan. f ... | 2017 | 29059250 |
| molecular mechanisms of intrinsic streptomycin resistance in mycobacterium abscessus. | streptomycin, the first drug used for the treatment of tuberculosis, shows limited activity against the highly resistant pathogen mycobacterium abscessus we recently identified two aminoglycoside-acetylating genes [aac(2') and eis2] which, however, do not affect susceptibility to streptomycin. this suggests the existence of a discrete mechanism of streptomycin resistance. m. abscessus blastp analysis identified mab_2385 as a close homologue of the 3″-o-phosphotransferase [aph(3″)] from the oppor ... | 2018 | 29061744 |
| in vitro evaluation of povidone-iodine and chlorhexidine against outbreak and nonoutbreak strains of mycobacterium abscessus using standard quantitative suspension and carrier testing. | povidone-iodine (pi) and chlorhexidine (chx) are widely used antiseptics active against conventional staphylococcus aureus, enterobacteriaceae, candida species, and viruses, but their efficacy against mycobacterium abscessus remains unproven. we determined the in vitro potency of alcoholic pi and chx against m. abscessus subsp. abscessus (atcc 19977), m. abscessus subsp. bolletii (bcrc 16915), and our outbreak strain of m. abscessus subsp. massiliense (tpe 101) in reference to staphylococcus aur ... | 2018 | 29061748 |
| rapid detection of mutations in erm(41) and rrl associated with clarithromycin resistance in mycobacterium abscessus complex by denaturing gradient gel electrophoresis. | clarithromycin resistance is increasing dramatically among mycobacterium abscessus complex. the main resistance mechanisms are mutations in the erm(41) and rrl genes. here we report pcr-based denaturing gradient gel electrophoresis (dgge) as an alternative method for rapidly detection of mutations in erm(41) and rrl among m. abscessus isolates. four primer sets targeting the full-length erm(41) gene and a 354bp fragment of the rrl gene were designed. a combination of 16 different dgge patterns w ... | 2017 | 29079298 |
| in vitro activity between linezolid and other antimicrobial agents against mycobacterium abscessus complex. | linezolid (lzd) serves as an effective option in the treatment of mycobacterium abscessus complex (mabc) infection. unfortunately, the combined activities of lzd with other antimicrobial agents against mabc have not been evaluated systemically. in this study, we randomly selected 32 mycobacterium abscessus and 32 mycobacterium massiliense isolates for the determination of in vitro synergistic effect between lzd and other antimicrobial agents, including amikacin (amk), moxifloxacin (mox), cefoxit ... | 2018 | 29089153 |
| lack of association between rrl and erm(41) mutations and clarithromycin resistance in mycobacterium abscessus complex. | mycobacterium abscessus complex (mabc) includes species with high resistance rates among mycobacterial pathogens. in fact, mabc infections may not respond to clarithromycin treatment, which has historically been very effective against mabc infection. molecular markers have been proposed to detect both acquired (rrl polymorphisms) and inducible (erm(41) polymorphisms) clarithromycin resistance in mabc isolates. | 2017 | 29091138 |
| antimicrobial resistance in mycobacterium abscessus complex isolated from patients with skin and soft tissue infections at a tertiary teaching hospital in taiwan. | mycobacterium abscessus complex (mabc) is the most common non-tuberculous mycobacterium that causes complicated skin and soft tissue infections (csstis). the selection of antimycobacterial agents for successful treatment of such infections is a critical issue. | 2017 | 29091186 |
| genomic comparisons reveal microevolutionary differences in mycobacterium abscessus subspecies. | mycobacterium abscessus, a rapid-growing non-tuberculous mycobacterium, has been the cause of sporadic and outbreak infections world-wide. the subspecies in m. abscessus complex (m. abscessus, m. massiliense, and m. bolletii) are associated with different biologic and pathogenic characteristics and are known to be among the most frequently isolated opportunistic pathogens from clinical material. to date, the evolutionary forces that could have contributed to these biological and clinical differe ... | 2017 | 29109707 |
| antibiofilm activity of nanoemulsions of cymbopogon flexuosus against rapidly growing mycobacteria. | rapidly growing mycobacteria (rgm) are opportunistic microorganisms that can cause both local and disseminated infections. when in biofilm, these pathogens become highly resistant to antimicrobials used in clinical practice. composed abundantly of polymeric substances, biofilms delay the diffusion of antimicrobials, preventing the drug from penetrating the deeper layers and having an effective action. therefore, the search for new and alternative therapeutic options has become of fundamental imp ... | 2017 | 29122674 |
| a temperature sensitive mycobacterium paragordonae induces enhanced protective immune responses against mycobacterial infections in the mouse model. | recently, we introduced a temperature sensitive mycobacterium spp., mycobacterium paragordonae (mpg). here, we checked its potential as a candidate for live vaccination against mycobacterium tuberculosis and mycobacterium abscessus. intravenous infections of mice with mpg led to lower colony forming units (cfus) compared to infection with bcg, suggesting its usefulness as a live vaccine. the analyses of immune responses indicated that the highly protective immunity elicited by mpg was dependent ... | 2017 | 29123166 |
| mycobacterium abscessus, a taxonomic puzzle. | 2018 | 29139343 | |
| lipoprotein glycosylation by protein-o-mannosyltransferase (mab_1122c) contributes to low cell envelope permeability and antibiotic resistance of mycobacterium abscessus. | lipoproteins are important components of the mycobacterial cell envelope due to their function in cell wall homeostasis and bacterial virulence. they are post-translationally modified with lipid- and glycosyl-residues in various species and interference with acylation or glycosylation leads to reduced growth and attenuated virulence in mycobacterium tuberculosis. lipoproteins are also expressed in the emerging and highly drug resistant pathogen mycobacterium abscessus which frequently affects th ... | 2017 | 29163413 |
| nucleotide-binding oligomerization domain 2 contributes to limiting growth of mycobacterium abscessus in the lung of mice by regulating cytokines and nitric oxide production. | mycobacterium abscessus is a prominent cause of pulmonary infection in immunosuppressed patients and those with cystic fibrosis. nucleotide-binding oligomerization domain (nod) 2 is a cytosolic receptor which senses a bacterial peptidoglycan component, muramyl dipeptide (mdp). although nucleotide-binding oligomerization domain 2 (nod2) contributes to protect host against various microbial infections, it is still unclear whether nod2 is essential to regulate host immune responses against m. absce ... | 2017 | 29163541 |
| antibiotic resistance in mycobacterium abscessus and mycobacterium fortuitum isolates from malaysian patients. | rapidly growing mycobacterial species (rgm) are increasingly being recognized as the cause of various superficial and deep infections in humans. two of the species most frequently isolated from clinical specimens are mycobacterium abscessus and mycobacterium fortuitum. both species are associated with antibiotic resistances that may complicate therapy. this paper describes the pattern of resistance to five antibiotics commonly prescribed for rgm infections, in m. abscessus and m. fortuitum isola ... | 2017 | 29171453 |
| reporter-based assays for high-throughput drug screening against mycobacterium abscessus. | mycobacterium abscessus is a non-tuberculous mycobacterium that causes pulmonary and non-pulmonary infections. m. abscessus is resistant to many chemotherapeutic agents and the current treatment options show poor clinical outcomes. thus, there is a dire need to find new antimicrobials effective at killing m. abscessus. screening drug libraries to identify potential antimicrobials has been impeded by the lack of validated hts assays for m. abscessus. in this study, we developed two 384-well high- ... | 2017 | 29176967 |
| risk factors for the development of chronic pulmonary aspergillosis in patients with nontuberculous mycobacterial lung disease. | nontuberculous mycobacterial lung disease (ntm-ld) is increasingly recognized as an important predisposing condition for the development of chronic pulmonary aspergillosis (cpa), but there are limited data on the risk factors for cpa development in ntm-ld patients. we reviewed the medical records of 566 patients who, at the time of diagnosis of ntm-ld, did not have cpa and who received ≥12 months of treatment for ntm-ld between january 2010 and june 2015. of these patients, 41 (7.2%) developed c ... | 2017 | 29190796 |
| curcumin, an antibiotic resistance breaker against a multiresistant clinical isolate of mycobacterium abscessus. | curcumin, a phenolic compound extracted from curcuma longa, exerts multiple pharmacological effects, including an antimicrobial action. mycobacterium abscessus, an environmental, nontuberculous, rapidly growing mycobacterium, is an emerging human pathogen causing serious lung infections and one of the most difficult to treat, due to its multidrug resistance and biofilm-forming ability. we wanted to evaluate the antimicrobial and antivirulence activity of curcumin and its ability to synergize wit ... | 2017 | 29193368 |
| activity of rifabutin and hemi-synthetic derivatives against mycobacterium abscessus. | mycobacterium abscessus causes a wide range of clinical diseases that are difficult to treat. this microorganism is resistant not only to the classical antituberculosis agents but also to most of the antimicrobials that are currently available, resulting in limited therapeutic options and treatment failure. this scenario stresses the need to search for new drugs with activity against m. abscessus. | 2017 | 29205119 |
| in vitro activity of tedizolid against the mycobacterium abscessus complex. | infections due to mycobacterium abscessus carry a poor prognosis since this rapidly growing mycobacterium is intrinsically resistant to most antibiotics. here, we evaluate the in vitro activity of the new oxazolidinone tedizolid against a collection of 44m. abscessus clinical isolates. the mic50s and mic90s of tedizolid (2 and 8μg/ml, respectively) were 2- to 16-fold lower than those of linezolid. there was no difference between the 3m. abscessus subspecies. time-kill assays did not show any bac ... | 2017 | 29217419 |
| association between sequevar and antibiotic treatment outcome in patients with mycobacterium abscessus complex infections in japan. | macrolide susceptibility differs between subspecies in the mycobacterium abscessus complex, likely due to differences in erm(41) sequevars. patients with m. abscessus complex infection generally show poor clinical outcomes in response to antibiotic treatment. here, the association between genotype and treatment outcome was investigated. | 2018 | 29227218 |
| successful use of linezolid for refractory mycobacterium abcessus infection: a case report. | a 51-year-old male patient was receiving treatment for mycobacterium abscessus infection for approximately 10 years. however, as his condition gradually progressed to type ii respiratory insufficiency, he was referred to our hospital, which was near his home. computed tomography on his first visit revealed an abscess in the right lower lobe. because respiratory insufficiency was evident, he was admitted the same day. we began treatment with meropenem, amikacin, and clarithromycin, but his sympto ... | 2018 | 29234594 |
| cyclophostin and cyclipostins analogs, new promising molecules to treat mycobacterial-related diseases. | the progression of mycobacterial diseases requires the development of new therapeutics. here, we evaluated the efficacy and selectivity of a panel of cyclophostin and cyclipostins analogs (cycs) against various bacteria and mycobacteria. the activity of these 26 cycs was first assayed using the agar plate method. compounds exhibiting a 50-100% growth inhibition rate were then selected to determine their mic using the rema assay. the best drug candidate was further tested against mycobacterial cl ... | 2017 | 29241819 |
| acute postcataract endophthalmitis at a referral center in northern taiwan: causative organisms, clinical features, and visual acuity outcomes after treatment: a retrospective cohort study. | acute-onset endophthalmitis after cataract surgery is a rare but serious complication. in this study, we identified the clinical profile of acute-onset endophthalmitis after cataract surgery using a retrospective review between january 1, 2009 and december 31, 2015 at a referral center in northern taiwan. twenty-five eyes of 25 patients with endophthalmitis were included; 60% were male. the mean age at diagnosis was 70.44 ± 1.66 years. the right eye was affected in 44% of patients. the mean time ... | 2017 | 29245262 |
| mycobacterium abscessus osteomyelitis of the calcaneus presenting as tumor-mimicking lesions: a case report. | we present the case of a 51-year-old immunocompetent man with refractory heel pain who initially had been treated for plantar fasciitis. however, the pain was proven to be caused by a mycobacterium abscessus infection of the calcaneus. the process of diagnosis and treatment is described. | 2017 | 29252886 |
| implication of species change of nontuberculous mycobacteria during or after treatment. | co-existence or subsequent isolation of multiple nontuberculous mycobacteria (ntm) species in same patient has been reported. however, clinical significance of these observations is unclear. the aim of this study was to determine clinical implications of changes of ntm species during or after treatment in patients with ntm lung disease. | 2017 | 29262802 |
| aspergillus fumigatus pre-exposure worsens pathology and improves control of mycobacterium abscessus pulmonary infection in mice. | cystic fibrosis (cf) is an autosomal recessive disease caused by mutations in the cf transmembrane conductance regulator (cftr) gene. mutations in this chloride channel lead to mucus accumulation, subsequent recurrent pulmonary infections and inflammation, which in turn cause chronic lung disease and respiratory failure. recently, rates of non-tuberculous mycobacterial (ntm) infections in cf patients have been increasing. of particular relevance is infection with mycobacterium abscessus, which c ... | 2017 | 29263106 |
| pleurisy caused by mycobacterium abscessus in a young patient with dermatomyositis: a case report and brief review of the literature. | m. abscessus is a rapidly growing mycobacteria (rgm) and is the most common cause of pulmonary rgm infection. m. abscessus pleurisy is extremely rare. we herein report the case of a young patient with m. abscessus pleurisy without any lung lesions. a laboratory analysis of the pleural effusion revealed lymphocyte predominance and increased adenosine deaminase, similar to the findings observed in tuberculous pleurisy. the patient was initially treated for tuberculous pleurisy, which resulted in t ... | 2017 | 29269658 |
| genetic correlates of clarithromycin susceptibility among isolates of the mycobacterium abscessus group and the potential clinical applicability of a pcr-based analysis of erm(41). | to define the genetic basis of clarithromycin resistance among isolates of the mycobacterium abscessus group (mag). | 2017 | 29272470 |
| isolated subcutaneous nontuberculous mycobacterial infection: a rare case initially mischaracterized as a soft tissue malignancy. | the occurrence of nontuberculous mycobacterial (ntm) infection is rare, and the involvement of the musculoskeletal system is even less common. however, the incidence of soft tissue and skin ntm infection is increasing, particularly in patients who undergo injections and minor surgical procedures. given the non-specific clinical manifestations of ntm infection, the lack of knowledge among physicians regarding this rare infection could lead to inaccurate and delayed diagnosis. herein, we present a ... | 2017 | 29273829 |
| mycobacterium abscessus disease in lung transplant recipients: diagnosis and management. | mycobacterium abscessus complex (mabsc ) disease in lung transplant recipients is increasingly being recognized as an important cause of graft function decline and suboptimal outcomes. lung transplant recipients appear to be at the highest risk of mabsc among solid organ transplant recipients, as they have more intense immunosuppression, and the organisms preferentially inhabit the lungs. mabsc is the most resistant species of rapidly growing mycobacteria and difficult to treat, causing consider ... | 2017 | 29276785 |
| mycobacterium abscessus smooth and rough morpohotypes form antimicrobial-tolerant biofilm phenotypes but are killed by acetic acid. | mycobacterium abscessus has emerged as an important pathogen in people with chronic inflammatory lung diseases such as cystic fibrosis, and recent reports suggest that it may be transmissible by fomites. m. abscessus exhibits two major colony morphology variants: a smooth morphotype (masm ) and a rough morphotype (marg ). biofilm formation, prolonged intracellular survival, and colony variant diversity can each contribute to the persistence of m. abscessus and other bacterial pathogens in chroni ... | 2018 | 29311080 |
| treatment outcomes of macrolide-susceptible mycobacterium abscessus lung disease. | mycobacterium abscessus lung disease is difficult to treat due to inducible resistance to macrolides. however, 15%-20% of isolates are macrolide susceptible. in 14 patients with macrolide-susceptible m. abscessus lung disease, all isolates had nonfunctional erm(41) gene, and sputum culture conversion rate was achieved in 93% (13/14) following antibiotic therapy. | 2017 | 29329759 |
| amplification of hsp 65 gene and usage of restriction endonuclease for identification of non tuberculous rapid grower mycobacterium. | the rapid grower mycobacteria have emerged as significant group of human pathogen amongst the runyon group iv organisms that are capable of causing infection in both the healthy and immunocompromised hosts. study aimed to identification of species amongst rapid grower non tuberculous mycobacterial isolates by polymerase chain reaction - restriction enzyme analysis (pra). analysis and comparison of results with standard biochemical tests. | 2018 | 29332650 |
| identification of genes required for mycobacterium abscessus growth in vivo with a prominent role of the esx-4 locus. | mycobacterium abscessus, a rapidly growing mycobacterium (rgm) and an opportunistic human pathogen, is responsible for a wide spectrum of clinical manifestations ranging from pulmonary to skin and soft tissue infections. this intracellular organism can resist the bactericidal defense mechanisms of amoebae and macrophages, an ability that has not been observed in other rgm. m. abscessus can up-regulate several virulence factors during transient infection of amoebae, thereby becoming more virulent ... | 2018 | 29343644 |