Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| antibodies to periodontal pathogens are associated with coronary plaque remodeling but not with vulnerability or burden. | previous studies have suggested positive associations between periodontal infection and cardiovascular disease. we aimed to investigate the associations of circulating antibodies against periodontal pathogens with 1-year cardiovascular outcome, as well as the extent of coronary atherosclerosis, plaque vulnerability and lesion remodeling on intravascular ultrasound (ivus) imaging. | 2014 | 25233105 |
| polymerase chain reaction as a prospect for the early diagnosis and prediction of periodontal diseases in adolescents. | this study was to determine the markers representative of pathogenic periodontal microflora [prevotella intermedia (p.i), tannerella forsythia (t.f) [bacteroides forsythus], treponema denticola (t.d), actinobacillus actinomycetemcomitans (a.a), porphyromonas gingivalis (p.g)] in the dental plaque of adolescents with various degrees of severity of periodontium inflammation. | 2015 | 25266040 |
| role of porphyromonas gingivalis gingipains in multi-species biofilm formation. | periodontal diseases are polymicrobial diseases that cause the inflammatory destruction of the tooth-supporting (periodontal) tissues. their initiation is attributed to the formation of subgingival biofilms that stimulate a cascade of chronic inflammatory reactions by the affected tissue. the gram-negative anaerobes porphyromonas gingivalis, tannerella forsythia and treponema denticola are commonly found as part of the microbiota of subgingival biofilms, and they are associated with the occurren ... | 2014 | 25270662 |
| evaluation of adjunctive systemic doxycycline with non-surgical periodontal therapy within type 2 diabetic patients. | to evaluate the effects of systemic doxycycline on clinical and microbiological parameters of diabetic subjects with chronic periodontitis. | 2014 | 25316464 |
| the effect of conventional mechanical periodontal treatment on red complex microorganisms and clinical parameters in down syndrome periodontitis patients: a pilot study. | periodontal disease (pd) is induced by a complex microbiota, such as porphyromonas gingivalis, tannerella forsythia, and treponema denticola (together called the red complex), which triggers intense inflammatory reaction. down syndrome (ds) individuals demonstrate a high prevalence of pd compared with those who are otherwise chromosomally normal (euploids). this pilot study aimed to evaluate the effect of non-surgical periodontal treatment in ds chronic periodontitis patients on clinical and mic ... | 2015 | 25367612 |
| occurrence of socransky red complex in pregnant women with and without periodontal disease. | to verify the presence of socransky red complex (porphyromonas gingivalis, treponema denticola and tannerella forsythia) and p. intermedia using polymerase chain reaction (pcr) in periodontally healthy pregnant women and pregnant women with periodontal disease, as well as its relation to arterial blood pressure and capillary glycaemia. | 2015 | 25386627 |
| prevalence of six periodontal pathogens in subgingival samples of italian patients with chronic periodontitis. | the aim of this study was to investigate the subgingival prevalence of six periodontal pathogens in 352 italian patients with chronic periodontitis. possible correlations with clinical parameters, age, gender and smoking status were also investigated. at first visit a pooled subgingival plaque sample was obtained for each subject by using the paper-point method. the samples were processed and analysed according to a commercially available quantitative real time polymerase chain reaction assay (m ... | 2014 | 25387289 |
| miropin, a novel bacterial serpin from the periodontopathogen tannerella forsythia, inhibits a broad range of proteases by using different peptide bonds within the reactive center loop. | all prokaryotic genes encoding putative serpins identified to date are found in environmental and commensal microorganisms, and only very few prokaryotic serpins have been investigated from a mechanistic standpoint. herein, we characterized a novel serpin (miropin) from the human pathogen tannerella forsythia, a bacterium implicated in initiation and progression of human periodontitis. in contrast to other serpins, miropin efficiently inhibited a broad range of proteases (neutrophil and pancreat ... | 2014 | 25389290 |
| mirolase, a novel subtilisin-like serine protease from the periodontopathogen tannerella forsythia. | the genome of tannerella forsythia, an etiological factor of chronic periodontitis, contains several genes encoding putative proteases. here, we characterized a subtilisin-like serine protease of t. forsythia referred to as mirolase. recombinant full-length latent promirolase [85 kda, without its signal peptide (sp)] processed itself through sequential autoproteolytic cleavages into a mature enzyme of 40 kda. mirolase latency was driven by the n-terminal prodomain (ntp). in stark contrast to alm ... | 2015 | 25391881 |
| association between maternal periodontitis and preterm and/or low birth weight infants in normal pregnancies. | to relate the periodontal condition with the presence of periodontal bacteria in pregnant that had babies with preterm delivery or/and low weight at birth (ptlbw). | 2016 | 25394610 |
| shifts in campylobacter species abundance may reflect general microbial community shifts in periodontitis progression. | oral campylobacter species have been found to be associated with periodontitis progression. while the etiological significance of campylobacter rectus is quite established, the association of c. gracilis, c. concisus, and c. curvus with health or disease remains contradictory. | 2014 | 25412608 |
| antimicrobial effect of lactobacillus reuteri on cariogenic bacteria streptococcus gordonii, streptococcus mutans, and periodontal diseases actinomyces naeslundii and tannerella forsythia. | lactic acid bacteria (lab) are well known for their beneficial effects on human health in the intestine and immune system; however, there are few studies on the impact they can generate in oral health. the aim of this study was to test and compare in vitro antimicrobial activity of l. reuteri on pathogenic bacteria involved in the formation of dental caries: s. mutans, s. gordonii, and periodontal disease: a. naeslundii and t. forsythia. also, we determined the growth kinetics of each bacterium ... | 2015 | 25422124 |
| bovine milk fermented with lactobacillus rhamnosus l8020 decreases the oral carriage of mutans streptococci and the burden of periodontal pathogens. | the aim of this study was to find the oral isolate of lactobacilli, which has the potential to inhibit either periodontal, cariogenic, or fungal pathogens in vitro, and to examine the effects of bovine milk fermented with the isolate on the oral carriage of cariogenic and periodontal pathogens. | 2011 | 25426790 |
| detection rates of presumptive periodontal pathogens in subgingival plaque samples of untreated periodontitis using either four or six pooled samples. | a comparison of the detection frequency and number of periodontal pathogens in patients with aggressive or generalized, severe chronic periodontitis using a gene-probe analysis. | 2010 | 25427269 |
| detection of periodontal pathogens in the patients with aortic aneurysm. | the occurrence and development of aortic aneurysm (aa) are associated with infection. some researchers have detected the dna of periodontal pathogens in aa samples in certain populations. however, it has not been done in chinese population. the objective of this study was to evaluate the prevalence of periodontal pathogens in oral tissue samples and aneurysm samples of aa patients. | 2014 | 25430459 |
| subgingival microbial profile and production of proinflammatory cytokines in chronic periodontitis. | this review examines literature data concerning the bacterial findings in chronic periodontitis depending on pocket depth, and presents the latest published information on the presence of proinflammatory factors in periodontal environment. it has been found that chronic periodontitis affects as much as 80% of the middle-aged population; by comparison, the prevalence of aggressive periodontitis reaches up to 1-1.5%. it is accepted that this social disease is multifactorial in etiology, but the ev ... | 2014 | 25434071 |
| electrophoresis of periodontal pathogens in poly(ethyleneoxide) solutions with uncoated capillary. | periodontitis is a prevalent inflammatory disease caused by different species of anaerobic bacteria such as porphyromonas gingivalis (p.g), treponema denticola (t.d), and tannerella forsythia (t.f). we compared the separation result of dna ladders in hydroxyethyl cellulose, poly(ethyleneoxide) (peo), and polyethylene glycol and analyzed the effect of polymer concentration, electric field, and temperature of the background electrolyte on the separation performance. results demonstrated that there ... | 2015 | 25447490 |
| high-resolution taxonomic profiling of the subgingival microbiome for biomarker discovery and periodontitis diagnosis. | the oral microbiome plays a key role for caries, periodontitis, and systemic diseases. a method for rapid, high-resolution, robust taxonomic profiling of subgingival bacterial communities for early detection of periodontitis biomarkers would therefore be a useful tool for individualized medicine. here, we used illumina sequencing of the v1-v2 and v5-v6 hypervariable regions of the 16s rrna gene. a sample stratification pipeline was developed in a pilot study of 19 individuals, 9 of whom had been ... | 2015 | 25452281 |
| adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial. | the aim of the present study was to evaluate the clinical and microbiological efficacy of moxifloxacin (mox) in one-stage scaling and root planing (srp) in treating generalized aggressive periodontitis (gagp). | 2015 | 25469723 |
| clinical, microbial, and immune responses observed in patients with diabetes after treatment for gingivitis: a three-month randomized clinical trial. | although patients with diabetes are frequently affected by periodontitis, only a few investigations have focused on gingivitis in this at-risk population. this randomized placebo-controlled clinical trial compared the response to a gingivitis treatment protocol that combined mechanical procedures and daily use of an essential oil (eo) mouthrinse between patients with and without diabetes. | 2015 | 25494658 |
| investigate the correlation between clinical sign and symptoms and the presence of p. gingivalis, t. denticola, and t. forsythia individually or as a "red complex" by a multiplex pcr method. | the aim of this study was to investigate the correlation between endodontic clinical signs and symptoms and the presence of porphyromonas gingivalis, treponema denticola, and tannerella forsythia or their association by multiplex polymerase chain reaction assay. | 2014 | 25506144 |
| subgingival microbial profile and production of proinflammatory cytokines in chronic periodontitis. | this review examines literature data concerning the bacterial findings in chronic periodontitis depending on pocket depth, and presents the latest published information on the presence of proinflammatory factors in periodontal environment. it has been found that chronic periodontitis affects as much as 80% of the middle-aged population; by comparison, the prevalence of aggressive periodontitis reaches up to 1-1.5%. it is accepted that this social disease is multifactorial in etiology, but the ev ... | 2014 | 25507669 |
| serum igg antibody levels to periodontal microbiota are associated with incident alzheimer disease. | periodontitis and alzheimer disease (ad) are associated with systemic inflammation. this research studied serum igg to periodontal microbiota as possible predictors of incident ad. | 2014 | 25522313 |
| microbiological effects of periodontal therapy plus azithromycin in patients with diabetes: results from a randomized clinical trial. | current evidence suggests that periodontal infection may aggravate diabetes control. the aim of this study was to determine the changes in the frequency with which porphyromonas gingivalis, tannerella forsythia, treponema denticola and aggregatibacter actinomycetemcomitans were detected in patients with diabetes with the use of non-surgical therapy plus azithromycin in a randomized clinical trial. one hundred and five (105) patients with diabetes and chronic periodontitis were randomly assigned ... | 2014 | 25523961 |
| distribution of 8 periodontal microorganisms in family members of chinese patients with aggressive periodontitis. | to date, no information on the distribution of periodontal microorganisms among family members of chinese patients with aggressive peridontitis (agp) is available. the aim of the present study was to investigate the probability of transmission of eight periodontal microorganisms between patients with aggressive periodontitis and their family members. | 2015 | 25526624 |
| analysis of p. gingivalis, t. forsythia and s. aureus levels in edentulous mouths prior to and 6 months after placement of one-piece zirconia and titanium implants. | it has been suggested that completely edentulous patients harbour fewer periodontopathic bacteria compared with dentate patients, due to the removal of the subgingival periodontal environment. however, reappearance of certain microbes has been reported after the placement of implants in these patients. | 2016 | 25529603 |
| the effect of il-4 gene polymorphisms on cytokine production in patients with chronic periodontitis and in healthy controls. | chronic periodontitis (cp) is an inflammatory disease of the teeth-supporting tissues in which genetic predisposition, dental plaque bacteria, and immune mechanisms all play important roles. the aim of this study was to evaluate the occurrence of il-4 gene polymorphisms in chronic periodontitis and to investigate the association between polymorphisms and cytokines production after bacterial stimulation. sixty-two subjects (47 cp patients and 15 healthy controls) with detected two polymorphisms i ... | 2014 | 25530681 |
| microbial leakage at the implant-abutment connection due to implant insertion maneuvers: cross-sectional study 5 years postloading in healthy patients. | the aim of this study was to test if stress on the prosthetic connection during insertion maneuvers can induce micro-warping at the implant connection. from september 2011 to july 2013, patients with implants loaded for at least 5 years that were placed with 2 different insertion implant mounters-mp (conventional) and me (mountless)-were selected from all of those who had received dental implant therapy in the past and were attending routine check-up or spontaneous visits during the study period ... | 2015 | 25536224 |
| a novel mechanism of latency in matrix metalloproteinases. | the matrix metalloproteinases (mmps) are a family of secreted soluble or membrane-anchored multimodular peptidases regularly found in several paralogous copies in animals and plants, where they have multiple functions. the minimal consensus domain architecture comprises a signal peptide, a 60-90-residue globular prodomain with a conserved sequence motif including a cysteine engaged in "cysteine-switch" or "velcro" mediated latency, and a catalytic domain. karilysin, from the human periodontopath ... | 2015 | 25555916 |
| combinations of bacterial species associated with symptomatic endodontic infections in a chinese population. | to use microarrays to detect 11 selected bacteria in infected root canals, revealing bacterial combinations that are associated with clinical symptoms and signs of primary endodontic infections in a chinese population. | 2016 | 25565631 |
| association between immunoglobulin g1 against tannerella forsythia and reduction in the loss of attachment tissue. | to evaluate whether the levels of immunoglobulin g (igg) antibody to tanerella forsythia are associated with periodontal status. | 2014 | 25568807 |
| effects of adjunctive daily phototherapy on chronic periodontitis: a randomized single-blind controlled trial. | the purpose of this randomized single-blind controlled trial was to elucidate the clinical and antimicrobial effects of daily phototherapy (pt) as an adjunct to scaling and root planing (srp) in patients with chronic periodontitis. | 2014 | 25568808 |
| methodological issues in the quantification of subgingival microorganisms using the checkerboard technique. | the reproducibility and reliability of quantitative microbiological assessments using the dna-dna hybridization "checkerboard method" (ckb) were assessed. the data originated from 180 chronic periodontitis patients, who were enrolled in a clinical trial and sampled at baseline, and 3 and 12m post-therapy. the samples were divided into two portions allowing evaluation of reproducibility. in total, 531 samples were analyzed in a first run, using standard bacterial preparations of cells and 513 sam ... | 2015 | 25601790 |
| periodontopathogen levels following the use of an er:yag laser in the treatment of chronic periodontitis. | inflammatory periodontal diseases are initiated by microbial biofilms. the reduction of the biofilm is important in the management of the disease. this study compares periodontopathogen levels following the treatment of chronic periodontitis using er:yag laser debridement and mechanical scaling and root planing. | 2015 | 25630495 |
| short-term effect of removal of fixed orthodontic appliances on gingival health and subgingival microbiota: a prospective cohort study. | the aim of this prospective longitudinal study was to assess and compare the microbiological and clinical parameters of patients wearing a fixed orthodontic appliance, as opposed to 10 days after the bracket had been removed following treatment. | 2015 | 25631494 |
| anti-hmuy antibodies specifically recognize porphyromonas gingivalis hmuy protein but not homologous proteins in other periodontopathogens. | given the emerging evidence of an association between periodontal infections and systemic conditions, the search for specific methods to detect the presence of p. gingivalis, a principal etiologic agent in chronic periodontitis, is of high importance. the aim of this study was to characterize antibodies raised against purified p. gingivalis hmuy protein and selected epitopes of the hmuy molecule. since other periodontopathogens produce homologs of hmuy, we also aimed to characterize responses of ... | 2015 | 25658942 |
| chronic oral infection with major periodontal bacteria tannerella forsythia modulates systemic atherosclerosis risk factors and inflammatory markers. | tannerella forsythia is a gram-negative anaerobic organism that inhabits the subgingival cavity and initiates connective tissue destruction and alveolar bone resorption in periodontal disease (pd). pd is a chronic immunoinflammatory disease and has been linked to several systemic diseases including atherosclerosis. this study evaluated the effects of a chronic oral infection with t. forsythia atcc 43037 on the induction of pd, inflammatory markers and atherosclerosis risk factors in hyperlipidem ... | 2015 | 25663343 |
| inter- and intra-test agreement of three commercially available molecular diagnostic tests for the identification of periodontal pathogens. | the aim of the study was to compare the agreement and reproducibility of three test kits (iai pado test 4⋅5®, micro-ident®, and carpegen® perio diagnostik) regarding the detection of porphyromonas gingivalis, tannerella forsythia, treponema denticola, and aggregatibacter actinomycetemcomitans. | 2015 | 25680706 |
| p. gingivalis in periodontal disease and atherosclerosis - scenes of action for antimicrobial peptides and complement. | according to the nhs, it is estimated that over 50% of the adult population are, to some extent, affected by gum disease and approximately 15% of uk population have been diagnosed with severe periodontitis. periodontitis, a chronic polymicrobial disease of the gums, causes inflammation in its milder form, whereas in its severe form affects the surrounding tissues and can result in tooth loss. during periodontitis, plaque accumulates and sits between the junctional epithelium and the tooth itself ... | 2015 | 25713575 |
| comparison of serum amyloid a protein and c-reactive protein levels as inflammatory markers in periodontitis. | the purpose of this study was to compare serum amyloid a (saa) protein levels with high-sensitive c-reactive protein (hs-crp) levels as markers of systemic inflammation in patients with chronic periodontitis. the association of serum titers of antibodies to periodontal microbiota and saa/hs-crp levels in periodontitis patients was also studied. | 2015 | 25722922 |
| a. actinomycetemcomitans profile and red complex bacterial species of an afro-brazilian community: a comparative study. | the primary aim of this cross-sectional study was to compare the levels of red complex bacteria between afro-brazilian and non afro-brazilian cohort. the secondary aim was to compare the distribution of both aggregatibacter actinomycetemcomitans serotype b and its jp2 strains among participants who harboured this bacterial species. | 2015 | 25757149 |
| a filifactor alocis-centered co-occurrence group associates with periodontitis across different oral habitats. | periodontitis is a highly prevalent polymicrobial disease worldwide, yet the synergistic pattern of the multiple oral pathogens involved is still poorly characterized. here, saliva, supragingival and subgingival plaque samples from periodontitis patients and periodontally healthy volunteers were collected and profiled with 16s rrna gene pyrosequencing. different oral habitats harbored significantly different microbiota, and segregation of microbiota composition between periodontitis and health w ... | 2015 | 25761675 |
| microbiologic observations after four treatment strategies among patients with periodontitis maintaining a high standard of oral hygiene: secondary analysis of a randomized controlled clinical trial. | the benefit of full-mouth disinfection (fdis) over traditional scaling and root planing (srp), with or without adjunctive metronidazole, when treating chronic destructive periodontitis remains equivocal, as does the long-term association between clinical and microbiologic outcomes after such strategies. the aim of this study is to examine the relationship between clinical and microbiologic outcomes of four different treatment strategies for chronic destructive periodontitis among patients who ma ... | 2015 | 25762359 |
| relationship between methanogenic archaea and subgingival microbial complexes in human periodontitis. | we compared the amounts of methanogenic archaea with ten of the most important periodontal pathogens in 125 clinical samples. correlation analysis suggests that the support of the periodontitis-associated bacterial consortium by methanogenic archaea may be driven through direct or indirect interactions with prevotella intermedia. | 2015 | 25797107 |
| antimicrobial photodynamic effect to treat residual pockets in periodontal patients: a randomized controlled clinical trial. | a randomized controlled clinical trial was designed to evaluate the efficacy of the photodynamic therapy (pdt) in the treatment of residual pockets of chronic periodontitis patients. | 2015 | 25808980 |
| periodontal therapy effects on nitrite related to oral bacteria: a 6-month randomized clinical trial. | nitrite is a biologic factor relevant to oral and systemic homeostasis. through an oral bacteria reduction process, it was suggested that periodontal therapy and chlorhexidine (chx) rinse could affect nitrite levels, leading to negative effects, such as an increase in blood pressure. this 6-month randomized clinical trial evaluated the effects of periodontal therapeutic protocols on salivary nitrite and its relation to subgingival bacteria. | 2015 | 25811847 |
| point-of-care detection of tannerella forsythia using an antigen-antibody assisted dielectrophoretic impedance measurement method. | the importance of periodontal treatment planning based on diagnosis with clinical detection of periodontal pathogens has been well recognized. however, reliable detection and quantification methods that can be conveniently used at chair-side have yet to be developed. this study aimed to evaluate the clinical use of a novel apparatus which uses an antigen-antibody reaction assisted dielectrophoretic impedance measurement (aa-depim) for the detection of a prominent periodontal pathogen, tannerella ... | 2015 | 25812473 |
| microbiota at teeth and implants in partially edentulous patients. a 10-year retrospective study. | to determine the microbiota at implants and adjacent teeth 10 years after placement of implants with a sandblasted and acid-etched surface. | 2016 | 25827437 |
| characterization of an α-l-fucosidase from the periodontal pathogen tannerella forsythia. | the periodontal pathogen tannerella forsythia expresses several glycosidases which are linked to specific growth requirements and are involved in the invasion of host tissues. α-l-fucosyl residues are exposed on various host glycoconjugates and, thus, the α-l-fucosidases predicted in the t. forsythia atcc 43037 genome could potentially serve roles in host-pathogen interactions. we describe the molecular cloning and characterization of the putative fucosidase tffuc1 (encoded by the bfo_2737 = tff ... | 2015 | 25831954 |
| occurrence of periodontal pathogens in ethnic groups from a native brazilian reservation. | the present study was designed to evaluate the occurrence of periodontal pathogens in the subgingival biofilm of 100 native brazilians living at the umutina indian reservation, mato grosso state, brazil. | 2015 | 25847068 |
| effects of non-equilibrium plasma in the treatment of ligature-induced peri-implantitis. | to evaluate the effects of non-equilibrium plasma in the treatment of ligature-induced peri-implantitis in beagle dogs. | 2015 | 25867215 |
| laser supported reduction of specific microorganisms in the periodontal pocket with the aid of an er,cr:ysgg laser: a pilot study. | the aim of this study was to evaluate the effectiveness of a radial firing tip of an er,cr:ysgg laser as an adjunct to a nonsurgical periodontal treatment. | 2015 | 25879057 |
| clinical, microbiological, and immunological aspects of healthy versus peri-implantitis tissue in full arch reconstruction patients: a prospective cross-sectional study. | due to the world-wide increase in treatments involving implant placement, the incidence of peri-implant disease is increasing. late implant failure is the result of the inability to maintain osseointegration, whose most important cause is peri-implantitis. the aim of this study was to analyze the clinical, microbiological, and immunological aspects in the peri-implant sulcus fluid (pisf) of patients with healthy dental implants and patients with peri-implantitis. | 2015 | 25888355 |
| bacterial profile of aggressive periodontitis in morocco: a cross-sectional study. | aggressive periodontitis (agp) is one of the most severe forms of periodontal diseases. in morocco, aggregatibacter actinomycetemcomitans has been strongly associated with agp, however limited knowledge is available about the implication of other periodontal pathogens in this entity. therefore, the main aim of this study was to evaluate the composition of the subgingival microbiota in moroccan patients with agp. | 2015 | 25888404 |
| full mouth periodontal debridement with or without adjunctive metronidazole gel in smoking patients with chronic periodontitis: a pilot study. | the evidence of effectiveness of metronidazole (mtz) as an adjunct therapy to periodontal procedure in the treatment of patients with chronic periodontitis is not conclusive. the aim of this study was to compare the effect of mtz (delivered locally as a gel or systemically as a tablet) as an adjunctive therapy with full mouth periodontal debridement (1 h of ultrasonic calculus/plaque removal) in smokers with chronic periodontitis. | 2016 | 25900347 |
| functional signatures of oral dysbiosis during periodontitis progression revealed by microbial metatranscriptome analysis. | periodontitis is a polymicrobial biofilm-induced inflammatory disease that affects 743 million people worldwide. the current model to explain periodontitis progression proposes that changes in the relative abundance of members of the oral microbiome lead to dysbiosis in the host-microbiome crosstalk and then to inflammation and bone loss. using combined metagenome/metatranscriptome analysis of the subgingival microbiome in progressing and non-progressing sites, we have characterized the distinct ... | 2015 | 25918553 |
| periodontal status and pathogenic bacteria after gastric bypass: a cohort study. | the aim this study was to evaluate the influence of gastric bypass surgery (gbs) on periodontal disease and quantify the periodontopathogenic bacteria in patients undergoing this surgery. | 2015 | 25924695 |
| development of in vitro denture biofilm models for halitosis related bacteria and their application in testing the efficacy of antimicrobial agents. | since dentures can serve as a reservoir for halitosis-causing oral bacteria, halitosis development is a concern for denture wearers. in this study, we surveyed the prevalence of four selected halitosis-related species (fusobacterium nucleatum, tannerella forsythia, veillonella atypica and klebsiella pneumoniae) in clinical denture plaque samples, and developed denture biofilm models for these species in vitro to facilitate assessment of antimicrobial treatment efficacy. design : denture plaque f ... | 2015 | 25926895 |
| outer membrane vesicles of tannerella forsythia: biogenesis, composition, and virulence. | tannerella forsythia is the only 'red-complex' bacterium covered by an s-layer, which has been shown to affect virulence. here, outer membrane vesicles (omvs) enriched with putative glycoproteins are described as a new addition to the virulence repertoire of t. forsythia. investigations of this bacterium are hampered by its fastidious growth requirements and the recently discovered mismatch of the available genome sequence (92a2 = atcc baa-2717) and the widely used t. forsythia strain (atcc 4303 ... | 2015 | 25953484 |
| klikk proteases of tannerella forsythia: putative virulence factors with a unique domain structure. | comparative genomics of virulent tannerella forsythia atcc 43037 and a close health-associated relative, tannerella bu063, revealed, in the latter, the absence of an entire array of genes encoding putative secretory proteases that possess a nearly identical c-terminal domain (ctd) that ends with a -lys-leu-ile-lys-lys motif. this observation suggests that these proteins, referred to as klikk proteases, may function as virulence factors. re-sequencing of the loci of the klikk proteases found only ... | 2015 | 25954253 |
| microbiome profiles in periodontitis in relation to host and disease characteristics. | periodontitis is an inflammatory condition that affects the supporting tissues surrounding teeth. the occurrence of periodontitis is associated with shifts in the structure of the communities that inhabit the gingival sulcus. although great inter-subject variability in the subgingival microbiome has been observed in subjects with periodontitis, it is unclear whether distinct community types exist and if differences in microbial signatures correlate with host characteristics or with the variable ... | 2015 | 25984952 |
| microbial dynamics during conversion from supragingival to subgingival biofilms in an in vitro model. | the development of dental caries and periodontal diseases result from distinct shifts in the microbiota of the tooth-associated biofilm. this in vitro study aimed to investigate changes in biofilm composition and structure, during the shift from a 'supragingival' aerobic profile to a 'subgingival' anaerobic profile. biofilms consisting of actinomyces oris, candida albicans, fusobacterium nucleatum, streptococcus oralis, streptococcus mutans and veillonella dispar were aerobically grown in saliva ... | 2016 | 26033167 |
| novel antimicrobial peptide specifically active against porphyromonas gingivalis. | porphyromonas gingivalis, the major etiologic agent of chronic periodontitis, produces a broad spectrum of virulence factors, including outer membrane vesicles, lipopolysaccharides, hemolysins and proteinases. antimicrobial peptides (amps) including bacteriocins have been found to inhibit the growth of p. gingivalis; however, these peptides are relatively large molecules. hence, it is difficult to synthesize them by a scale-up production. therefore, this study aimed to synthesize a shorter amp t ... | 2015 | 26041027 |
| evaluation of a hydrophobic gel adhering to the gingiva in comparison with a standard water-soluble 1% chlorhexidine gel after scaling and root planing in patients with moderate chronic periodontitis. a randomized clinical trial. | to evaluate the clinical, microbiological and enzymatic activity of a hydrophobic chlorhexidine-based gingiva-adhering gel containing herbal ingredients, compared with a commercially available 1% chlorhexidine water-soluble gel, during non-surgical therapy of moderate chronic periodontitis. | 2017 | 26053503 |
| porphyromonas gingivalis periodontal infection and its putative links with alzheimer's disease. | periodontal disease (pd) and alzheimer's disease (ad) are inflammatory conditions affecting the global adult population. in the pathogenesis of pd, subgingival complex bacterial biofilm induces inflammation that leads to connective tissue degradation and alveolar bone resorption around the teeth. in health, junctional epithelium seals the gingiva to the tooth enamel, thus preventing bacteria from entering the gingivae. chronic pd involves major pathogens (porphyromonas gingivalis, treponema dent ... | 2015 | 26063967 |
| draft genome sequence of tannerella forsythia type strain atcc 43037. | tannerella forsythia is an oral pathogen implicated in the development of periodontitis. here, we report the draft genome sequence of the tannerella forsythia strain atcc 43037. the previously available genome of this designation (ncbi reference sequence nc_016610.1) was discovered to be derived from a different strain, fdc 92a2 (= atcc baa-2717). | 2015 | 26067981 |
| subgingival microbiome in patients with healthy and ailing dental implants. | dental implants are commonly used to replace missing teeth. however, the dysbiotic polymicrobial communities of peri-implant sites are responsible for peri-implant diseases, such as peri-implant mucositis and peri-implantitis. in this study, we analyzed the microbial characteristics of oral plaque from peri-implant pockets or sulci of healthy implants (n = 10), peri-implant mucositis (n = 8) and peri-implantitis (n = 6) sites using pyrosequencing of the 16s rrna gene. an increase in microbial di ... | 2015 | 26077225 |
| periodontal bacteria and prediabetes prevalence in origins: the oral infections, glucose intolerance, and insulin resistance study. | periodontitis and type 2 diabetes mellitus are known to be associated. the relationship between periodontal microbiota and early diabetes risk has not been studied. we investigated the association between periodontal bacteria and prediabetes prevalence among diabetes-free adults. origins (the oral infections, glucose intolerance and insulin resistance study) cross sectionally enrolled 300 diabetes-free adults aged 20 to 55 y (mean ± sd, 34 ± 10 y; 77% female). prediabetes was defined as follows: ... | 2015 | 26082387 |
| prevalence of eight putative periodontal pathogens in atherosclerotic plaque of coronary artery disease patients and comparing them with noncardiac subjects: a case-control study. | the study was aimed to assess the prevalence of periodontal pathogens namely tannerella forsythia (t.f), campylobacter rectus (c.r), eikenella corrodens (e.c), porphyromonas gingivalis (p.g), treponema denticola (t.d), prevotella nigrescens (p.n) ,aggregatibacter actinomycetemcomitans (a.a), p.g (fi ma gene) and prevotella intermedia (p.i), in the subgingival and the atheromatous plaque of patients with coronary artery disease (cad), and comparing them with the noncardiac subjects thereby indica ... | 2017 | 26096116 |
| polybacterial periodontal pathogens alter vascular and gut bh4/nnos/nrf2-phase ii enzyme expression. | periodontal disease is a highly prevalent chronic inflammatory disease and is associated with complex microbial infection in the subgingival cavity. recently, american heart association supported a century old association between periodontal disease and atherosclerotic vascular disease. we have recently shown that polybacterial periodontal infection led to aortic atherosclerosis and modulation of lipid profiles; however the underlying mechanism(s) has not been yet demonstrated. altered nitric ox ... | 2015 | 26111153 |
| the biofilm community-rebels with a cause. | oral biofilms are one of the most complex and diverse ecosystem developed by successive colonization of more than 600 bacterial taxa. development starts with the attachment of early colonizers such as actinomyces species and oral streptococci on the acquired pellicle and tooth enamel. these bacteria not only adhere to tooth surface but also interact with each other and lay foundation for attachment of bridging colonizer such as fusobacterium nucleatum followed by late colonizers including the re ... | 2015 | 26120510 |
| periodontal pathogens and tetracycline resistance genes in subgingival biofilm of periodontally healthy and diseased dominican adults. | the objective of this study was to compare the periodontopathogen prevalence and tetracycline resistance genes in dominican patients with different periodontal conditions. | 2015 | 26121972 |
| comparison of the oral microbiomes of canines and their owners using next-generation sequencing. | the oral microbiome, which is closely associated with many diseases, and the resident pathogenic oral bacteria, which can be transferred by close physical contact, are important public health considerations. although the dog is the most common companion animal, the composition of the canine oral microbiome, which may include human pathogenic bacteria, and its relationship with that of their owners are unclear. in this study, 16s rdna pyrosequencing was used to compare the oral microbiomes of 10 ... | 2015 | 26134411 |
| tannerella forsythia is associated with increased levels of atherogenic low density lipoprotein and total cholesterol in chronic periodontitis. | accumulating evidence suggests that acute and chronic infections with periodontopathogens are associated with an increased risk of cardiovascular disease. the objective of this study was to assess whether tanerella forsythia and porphyromonas gingivalis are associated with increased levels of atherogenic low-density lipoprotein (ldl), high-density lipoprotein, total cholesterol (tc), triglycerides and body mass index (bmi) in chronic periodontitis patients. | 2015 | 26155342 |
| effects of hangeshashinto on growth of oral microorganisms. | oral mucositis (om) in cancer patients induced by chemotherapy or radiotherapy has a significant impact on quality of life, and causes considerable morbidity. oral microorganisms are likely to intensify the inflammatory process and aggravate the formation of ulcers. hangeshashinto (hst), a japanese kampo medicine, has been reported to be effective when used as a gargle for the treatment of om. to clarify the effects of hst on oral microorganisms, we assessed its antimicrobial activity against 27 ... | 2015 | 26170876 |
| impact of heavy smoking on the clinical, microbiological and immunological parameters of patients with dental implants: a prospective cross-sectional study. | the aim of the present study was to investigate how heavy smoking influences the clinical, microbiological, and host-response characteristics in peri-implant sulcus fluid of patients with healthy dental implants. | 2016 | 26171870 |
| pathogenic potential of tannerella forsythia enolase. | although enolases are cytosolic enzymes involved in the glycolytic pathway, they can also be secreted or expressed on the surface of a variety of eukaryotic cells and bacteria. surface-exposed enolases of eukaryotes and bacteria can function as plasminogen receptors. furthermore, antibodies raised against bacterial enolases can react with host enolases, suggesting molecular mimicry between bacterial and host enzymes. in this study, we analyzed an enolase of the major periodontopathogen tannerell ... | 2016 | 26172848 |
| tlr4, nod1 and nod2 mediate immune recognition of putative newly identified periodontal pathogens. | periodontitis is a polymicrobial inflammatory disease that results from the interaction between the oral microbiota and the host immunity. although the innate immune response is important for disease initiation and progression, the innate immune receptors that recognize both classical and putative periodontal pathogens that elicit an immune response have not been elucidated. by using the human oral microbe identification microarray (homim), we identified multiple predominant oral bacterial speci ... | 2016 | 26177212 |
| detection of subgingival periodontal pathogens--comparison of two sampling strategies. | the aim of the study is to compare detection frequency of periodontal pathogens in patients with aggressive/severe chronic periodontitis using pooled plaque samples from the deepest pockets per quadrant/per sextant. | 2016 | 26193958 |
| association of porphyromonas gingivalis with high levels of stress-induced hormone cortisol in chronic periodontitis patients. | the aim of the present study was to evaluate the association between the occurrence of periodontopathogens with cortisol levels in chronic periodontitis patients. | 2016 | 26194628 |
| a metalloproteinase mirolysin of tannerella forsythia inhibits all pathways of the complement system. | recent reports focusing on virulence factors of periodontal pathogens implicated proteinases as major determinants of remarkable pathogenicity of these species, with special emphasis on their capacity to modulate complement activity. in particular, bacteria-mediated cleavage of c5 and subsequent release of c5a seems to be an important phenomenon in the manipulation of the local inflammatory response in periodontitis. in this study, we present mirolysin, a novel metalloproteinase secreted by tann ... | 2015 | 26209620 |
| clinical and antimicrobial efficacy of a controlled-release device containing chlorhexidine in the treatment of chronic periodontitis. | a controlled-release device (crd) containing chlorhexidine gluconate, such as periocol(™)cg (eucare pharmaceuticals pvt. ltd,, chennai, india), for subgingival application has little reported data with clinical as well as antimicrobial efficacy. this study evaluated clinical and subgingival microbial changes on using indigenously developed periocol™cg as an adjunct to scaling and root planing (srp) in the treatment of chronic periodontitis. forty posterior first molar sites having probing pocket ... | 2015 | 26210387 |
| host response mechanisms in periodontal diseases. | periodontal diseases usually refer to common inflammatory disorders known as gingivitis and periodontitis, which are caused by a pathogenic microbiota in the subgingival biofilm, including porphyromonas gingivalis, aggregatibacter actinomycetemcomitans, tannerella forsythia and treponema denticola that trigger innate, inflammatory, and adaptive immune responses. these processes result in the destruction of the tissues surrounding and supporting the teeth, and eventually in tissue, bone and final ... | 2015 | 26221929 |
| antagonistic effect of peptidoglycan of streptococcus sanguinis on lipopolysaccharide of major periodontal pathogens. | streptococcus sanguinis is often found in subgingival biofilm including periodontopathogens, and is correlated with a delay in colonization by periodontopathogens. however, the effect of s. sanguinis on inflammation induced by periodontopathogens is poorly understood. thus, this study investigated the effect of s. sanguinis peptidoglycan (pgn) on induction of tnf-α, il-6, and il-8 expression by lipopolysaccharide (lps) of periodontal pathogens. lps was extracted from aggregatibacter actinomycete ... | 2015 | 26224458 |
| clinical and microbiologic evaluation of scaling and root planing per quadrant and one-stage full-mouth disinfection associated with azithromycin or chlorhexidine: a clinical randomized controlled trial. | conflicting data about the protocol of choice for non-surgical periodontal therapy with adjuvant use are still reported. this study aims to evaluate, through clinical and microbiologic parameters, the systemic use of azithromycin (az) and chlorhexidine (chx) as adjuvants to non-surgical periodontal treatment performed by one-stage full-mouth disinfection (fmd) within 24 hours or conventional quadrant scaling (qs) in four weekly sections. | 2015 | 26252751 |
| oral bacteria in placental tissues: increased molecular detection in pregnant periodontitis patients. | the objective of this study was to identify the dna of oral bacteria in placental samples from women with and without periodontitis who had or had not had preterm births and/or low birthweight (pb/lbw) neonates. | 2015 | 26259070 |
| inositol-phosphodihydroceramides in the periodontal pathogen tannerella forsythia: structural analysis and incorporation of exogenous myo-inositol. | unique phosphodihydroceramides containing phosphoethanolamine and glycerol have been previously described in porphyromonas gingivalis. importantly, they were shown to possess pro-inflammatory properties. other common human bacteria were screened for the presence of these lipids, and they were found, amongst others, in the oral pathogen tannerella forsythia. to date, no detailed study into the lipids of this organism has been performed. | 2015 | 26277409 |
| investigation of the oral status and microorganisms in children with phenylketonuria and type 1 diabetes. | the aim of this study was to investigate the oral parameters that influence the caries risk and risk of developing periodontal disease in children with phenylketonuria (pku) and type 1 diabetes compared to healthy children. | 2016 | 26297129 |
| the expression of gingival epithelial junctions in response to subgingival biofilms. | periodontitis is an infectious inflammatory disease that destroys the tooth-supporting tissues. it is caused by the formation of subgingival biofilms on the surface of the tooth. characteristic bacteria associated with subgingival biofilms are the gram-negative anaerobes porphyromonas gingivalis, tannerella forsythia and treponema denticola, collectively known as the "red complex" species. inter-epithelial junctions ensure the barrier integrity of the gingival epithelium. this may however be dis ... | 2015 | 26305580 |
| the association between subgingival periodontal pathogens and systemic inflammation. | to investigate associations between periodontal disease pathogens and levels of systemic inflammation measured by c-reactive protein (crp). | 2015 | 26309048 |
| porphyromonas gingivalis, aggregatibacter actinomycetemcomitans, and treponema denticola / prevotella intermedia co-infection are associated with severe periodontitis in a thai population. | periodontitis is a polymicrobial infection of tooth-supporting tissues. this cross-sectional study aimed to examine the associations between five target species and severe periodontitis in a thai population. using the cdc/aap case definition, individuals diagnosed with no/mild and severe periodontitis were included. quantitative analyses of aggregatibacter actinomycetemcomitans (aa), porphyromonas gingivalis (pg), tannerella forsythia (tf), treponema denticola (td), and prevotella intermedia (pi ... | 2015 | 26313005 |
| sialic acid transporter nant participates in tannerella forsythia biofilm formation and survival on epithelial cells. | tannerella forsythia is a periodontal pathogen implicated in periodontitis. this gram-negative pathogen depends on exogenous peptidoglycan amino sugar n-acetylmuramic acid (nam) for growth. in the biofilm state the bacterium can utilize sialic acid (neu5ac) instead of nam to sustain its growth. thus, the sialic acid utilization system of the bacterium plays a critical role in the growth and survival of the organism in the absence of nam. we sought the function of a t. forsythia gene annotated as ... | 2016 | 26318875 |
| qat chewing and periodontal pathogens in health and disease: further evidence for a prebiotic-like effect. | qat chewing has been reported to induce subgingival microbial shifts suggestive of prebiotic-like properties. the objective here was to assess the effect of qat chewing on a panel of classical and new putative periopathogens in health and periodontitis. | 2015 | 26351631 |
| subgingivally applied minocycline microgranules in subjects with chronic periodontitis: a randomized clinical and microbiological trial. | the aim of this study was to evaluate clinical and microbiological effects of subgingival minocycline microgranules when used as an adjunct to scaling and root planing in subjects with chronic periodontitis. twenty-six non-smoker volunteers participated in the study. four opposite sites, clinically standardized, with bleeding on probing (bop) and pocket depth (pd) ≥ 6 mm were selected. baseline bop, pd and clinical attachment level (cal) were measured and microbiological samples were collected f ... | 2015 | 26355881 |
| periodontal pathogens invade gingiva and aortic adventitia and elicit inflammasome activation in αvβ6 integrin-deficient mice. | the american heart association supports an association between periodontal diseases and atherosclerosis but not a causal association. this study explores the use of the integrin β6(-/-) mouse model to study the causality. we investigated the ability of a polymicrobial consortium of porphyromonas gingivalis, treponema denticola, tannerella forsythia, and fusobacterium nucleatum to colonize the periodontium and induce local and systemic inflammatory responses. polymicrobially infected itgβ6(-/-) m ... | 2015 | 26371120 |
| characterization of a sialate-o-acetylesterase (nans) from the oral pathogen tannerella forsythia that enhances sialic acid release by nanh, its cognate sialidase. | tannerella forsythia, a gram-negative member of the bacteroidetes has evolved to harvest and utilize sialic acid. the most common sialic acid in humans is a mono-n-acetylated version termed neu5ac (5-n-acetyl-neuraminic acid). many bacteria are known to access sialic acid using sialidase enzymes. however, in humans a high proportion of sialic acid contains a second acetyl group attached via an o-group, i.e. chiefly o-acetylated neu5,9ac2 or neu5,4ac2. this diacetylated sialic acid is not cleaved ... | 2015 | 26378150 |
| periodontal clinical and microbiological characteristics in healthy versus generalized aggressive periodontitis families. | generalized aggressive periodontitis (gap) is a severe and multifactorial disease in which a familial aggregation and a specific microbiological profile have been suggested. thus, this case-control study evaluated the clinical and subgingival microbial profile of gap subjects and their families compared to healthy families. | 2015 | 26392039 |
| the detection of bana micro-organisms in adult periodontitis before and after scaling and root planing by bana-enzymatic™ test kit: an in vivo study. | many paraclinical methods are available today for an accurate assessment of the periodontal status prior and during the periodontal treatment. the microbial-enzymatic n-benzoyl-dl-arginine-2-napthylamide (bana) test is one of the modern alternatives to bacterial cultures. it detects the presence of three periodontal pathogens in the subgingival plaque (porphyromonas gingivalis, treponema denticola and tannerella forsythia). | 2015 | 26392688 |
| oral microbiome in chinese patients with aggressive periodontitis and their family members. | to investigate the microbiome composition in chinese patients with aggressive periodontitis (agp), and to compare the similarity of bacterial profiles between agp patients and their family members. | 2015 | 26412568 |
| protein biomarkers and microbial profiles in peri-implantitis. | the aim of the present investigation was to determine the profile of peri-implant crevicular fluid (picf) biomarkers combined with microbial profiles from implants with healthy peri-implant tissues and peri-implantitis to assess real-time disease activity. | 2016 | 26424287 |