Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| rna polymerase complexes from mengovirus infected cells. | 1972 | 4341300 | |
| [pathology of diabetes mellitus in the white mouse infected with emc-virus. histological, electronmicroscopical and quantitative morphological findings in the islets of langerhans]. | 1972 | 4341575 | |
| capsid polypeptides of mouse elberfeld virus. i. amino acid compositions and molar ratios in the virion. | the four major polypeptide chains (alpha, beta, gamma, delta) constituting the capsid protein of mouse elberfeld (me) virus were isolated by preparative electrophoresis on polyacrylamide gels, and the amino acid composition of each chain was determined. in addition, the molecular weights of the smallest chains of me virus, mengovirus, and poliovirus, which had previously been determined by gel electrophoretic methods, were redetermined by gel filtration chromatography in 6 m guanidine hydrochlor ... | 1972 | 4342047 |
| increased mortality in encephalomyocarditis virus-infected mice consuming cobalt sulfate: tissue concentrations of cobalt. | 1972 | 4342332 | |
| effects of arsenicals on viral infections in mice. | 1972 | 4343075 | |
| insulin and the regulation of protein synthesis in muscle. | 1972 | 4343351 | |
| effect of vesicular stomatitis virus infection on the histocompatibility antigen of l cells. | when mouse l cells are infected for 22 hr with vesicular stomatitis virus (vsv), a ribonucleic acid-containing enveloped virus, greater than 70% of the major histocompatibility antigen (h-2), is no longer detectable by the method of inhibition of immune cytolysis. infected cells prelabeled with (14)c-glucosamine also show a correspondingly greater loss of trichloroacetic acid-insoluble radioactivity than uninfected cells. the loss of h-2 antigenic activity is not due to the viral inhibition of h ... | 1972 | 4343540 |
| differentiated change in polyribosome and free ribosome density with an increase in ionic strength. | 1972 | 4343833 | |
| [effect of 2-(alpha-hydroxybenzyl)-benzimidazole and guanidine on the activity of rna polymerases, induced by encephalomyocarditis viruses and poliovirus]. | 1972 | 4343925 | |
| immunization of mice against encephalomyocarditis virus. i. purification, concentration, and inactivation of encephalomyocarditis virus. | methods are described for the concentration, purification, and inactivation of encephalomyocarditis virus grown in l-cell suspension cultures. virus concentrates were obtained by the precipitation of crude virus lysates with polyethylene glycol and were purified by genetron extraction. after column chromatography approximately 70% recovery of infectivity and hemagglutination (ha) activity was found. exposure of the purified virus suspensions to ultraviolet light resulted in reduction of the infe ... | 1972 | 4344026 |
| immunization of mice against encephalomyocarditis virus. ii. intraperitoneal and respiratory immunization with ultraviolet-inactivated vaccine: effect of bordetella pertussis extract on the immune response. | mice were immunized by intraperitoneal (ip) or respiratory administration of ultraviolet-inactivated virus alone or with bordetella pertussis extract (bpe) as an adjuvant. the effect of immunization was tested by determination of antibody titers and by survival of a lethal challenge with 200 ld(50) of a virulent (large-plaque variant) strain of emc virus. for plain vaccine the ip 50% effective dose (ed(50)) was 37 hemagglutination units (hau; ca. 4 x 10(6) plaque-forming unit equivalents); with ... | 1972 | 4344027 |
| synthesis and cleavage of virus-specifici proteins in krebs ii carcinoma cells infected with encephalomyocarditis virus. | 1972 | 4344151 | |
| poly u tracts absent from viral rna. | 1972 | 4344177 | |
| kinetics of synthesis and cleavage of encephalomyocarditis virus-specific proteins. | 1972 | 4344195 | |
| virus-specific polypeptides in ascites cells infected with encephalomyocarditis virus. | 1972 | 4344313 | |
| hyporeactivity of infection: potential limitation to therapeutic use of interferon-inducing agents. | interferon inducers are generally most effective as antiviral agents when used prophylactically. one possible explanation for this is that animals develop a state of hyporeactivity during the course of a virus infection. such a progressive loss of capacity to produce interferon was observed with a representative group of interferon-inducing agents (polyinosinic-cytidylic acid, tilorone hydrochloride, new-castle disease virus, or a strain of encephalomyocarditis virus) during the course of a mode ... | 1972 | 4344367 |
| comparative studies of plaque variantes derived from a florida strain of venezuelan equine encephlomyelitis virus. | small- and large-plaque variants of a florida strain (fe 3-7c) of venezuelan equine encephalomyelitis virus were studied in vivo and in vitro. the small-plaque variant was less virulent in mice, hamsters, and guinea pigs than the large-plaque variant. the variants could be distinguished by calcium phosphate chromatography. the implications of plaque variants within a mixed virus population are discussed. | 1972 | 4344368 |
| differential susceptibility of male and female mice to encephalomyocarditis virus: effects of castration, adrenalectomy, and the administration of sex hormones. | male mice have been noted to be more susceptible to encephalomyocarditis (emc) virus than female animals. castration of male mice abolished this difference and resulted in enhanced resistance similar to that of female mice. this increase in resistance in castrated males could be eliminated by adrenalectomy. adrenalectomy alone increased susceptibility in male mice but not in female mice. the administration of a long-acting preparation of testosterone markedly increased susceptibility both in cas ... | 1972 | 4344392 |
| murine resistance to inhaled neisseria meningitidis after infection with an encephalomyocarditis virus. | a reduction in pulmonary anti-bacterial activity due to a preceding viral illness has been suggested as the mechanism responsible for some meningococcal infections of the lung. we investigated this proposed pathogenesis by infecting mice with airborne encephalomyocarditis virus (emc) and then challenging them 1, 4, and 7 days later with aerosols of neisseria meningitidis. meningococcal clearance was assessed by comparing the numbers of bacteria present immediately after inhaling the aerosols wit ... | 1972 | 4344397 |
| effects of arsenicals on interferon formation and action. | 1972 | 4345020 | |
| mechanism of interferon action: inhibition of viral messenger ribonucleic acid translation in l-cell extracts. | encephalomyocarditis (emc) virus ribonucleic acid (rna) stimulated the incorporation of (14)c-amino acids into polypeptides in cell-free systems using preincubated s10 extracts from l cells. incorporation was linear for over 2 hr. analysis of the tryptic peptides derived from the polypeptide products formed in response to emc rna showed them to be virus specific. the major product, a polypeptide of 140,000 in molecular weight, migrated on sodium dodecyl sulfate-polyacrylamide gels with one of th ... | 1972 | 4345494 |
| initiation of picornavirus protein synthesis in ascites cell extracts. | the current model of picornavirus protein formation implies that initiation of protein synthesis occurs at a single site on the viral rna, and that the large polypeptide formed is later cleaved. a direct test of this model was made in vitro by studying the incorporation of [(35)s]methionine from rabbit liver met-trna(m) (met) and fmet-trna(f) (met) into encephalomyocarditis virus rna-coded proteins in extracts of ehrlich ascites cells. the incorporation of n-formylmethionine was complete within ... | 1972 | 4345505 |
| translation of encephalomyocarditis viral rna in oocytes of xenopus laevis. | rna from encephalomyocarditis virus was injected into oocytes of xenopus laevis. after incubation of the oocytes in [(35)s]methionine, polyacrylamide gel electrophoresis showed that a new series of polypeptides had been synthesized. they were identical in size to the polypeptides that appeared in ascites cells after infection with this virus. electrophoretic and chromatographic analysis of the methionine-containing tryptic peptides from three of the induced polypeptides confirmed that they were ... | 1972 | 4345506 |
| isolation and subunit structure of polycytidylate-dependent rna polymerase of encephalomyocarditis virus. | a polycytidylate-dependent rna polymerase of encephalomyocarditis virus was isolated from infected bhk 21 cells. the enzyme was associated with a smooth-membrane fraction, from which it was extracted by a mixture of sodium dodecyl sulfate, triton x-100, and dithiothreitol, and further purified by chromatography on a dowex-1 column and by glycerol gradient sedimentation. analysis of a 6s glycerol gradient peak of rna polymerase activity by sodium dodecyl sulfate-polyacrylamide gel electrophoresis ... | 1972 | 4345509 |
| double-stranded rna as an inhibitor of protein synthesis and as a substrate for a nuclease in extracts of krebs ii ascites cells. | concentrations of double-stranded rna above about 0.1 mug/ml inhibit translation of encephalo-myocarditis viral rna and mouse globin messenger rna in extracts of krebs ii ascites cells. protein synthesis initially proceeds at the control rate, then abruptly shuts off in a manner similar to that observed in reticulocyte lysates [hunt, t. & ehrenfeld, e. (1971) nature new biol. 230, 91-94]. substantially higher concentrations of double-stranded rna are required to give this effect in ascites extra ... | 1973 | 4346034 |
| circularity and cross-linking in preparations of replicative form of encephalomyocarditis virus rna. | 1972 | 4346099 | |
| mechanism of interferon uptake in parental and somatic monkey-mouse hybrid cells. | dose-response curves of interferons in different sensitive cells are regularly sigmoidal. in somatic monkey-mouse hybrid cells, however, a significant decrease in the slope of the curve for primate interferon was observed, while the dose-response effect was unaltered for mouse interferon. high concentrations of primate interferon were 10- to 100-times less effective in hybrid clones than in parental monkey cv-1 cells; at low concentrations the antiviral effect was 10- to 20-times higher in hybri ... | 1973 | 4346894 |
| stimulation by reticulocyte initiation factors of protein synthesis in a cell-free system from krebs ii ascites cells. | 1972 | 4347125 | |
| picornaviral gene order: comparison of a rhinovirus with a cardiovirus. | we describe conditions for unmasking virus-specific protein synthesis in cells infected with rhinoviruses 1a and 2. the gene order and cleavage pattern of rhinovirus 1a show many similarities to those of encephalomyocarditis virus and of poliovirus. | 1973 | 4347432 |
| [preliminary observations on the behavior of glial cells in culture in the presence of noradrenaline, serotonin and the mm neurotropic virus]. | 1973 | 4347661 | |
| encephalomyocarditis virus (e variant) in mice. pancreatic changes. | 1973 | 4348435 | |
| the initiation of protein synthesis directed by the rna from encephalomyocarditis virus. | 1973 | 4348443 | |
| ultrastructural cytopathology of mouse myocardium associated with emc viral infection. | 1973 | 4348560 | |
| enhancement of interferon production of murine peritoneal leukocytes by mineral oil: the effect of experimental emc infection in mice. | 1973 | 4349471 | |
| specificity in initiation of protein synthesis in a fractionated mammalian cell-free system. | 1973 | 4349564 | |
| virus-induced diabetes mellitus. i. hyperglycemia and hypoinsulinemia in mice infected with encephalomyocarditis virus. | infection of dba/2n male mice with encephalomyocarditis virus resulted in a diabeteslike syndrome characterized by hyperglycemia, glycosuria, hypoinsulinemia, polydipsia, and polyphagia. blood glucose levels were elevated within 4 days after infection and reached a maximum mean level of 320 mg/100 ml within 12 days. approximately 60-80% of the animals developed a transient hyperglycemia while 10-15% of the animals remained hyperglycemic for well over 6 mo. the remaining animals failed to become ... | 1973 | 4349751 |
| study of two double-stranded ribonucleic acids of viral origin: interferon inducing and antiviral activities. | 1972 | 4349828 | |
| [detection of complement fixing antibodies against herpes simplex virus (and other neurotropic viruses) in patients with multiple sclerosis]. | 1973 | 4350584 | |
| antiviral activity of isoprinosine in vitro and in vivo. | 1973 | 4350802 | |
| protein synthesis directed by encephalomyocarditis virus mrna. 3. discrete polypeptides translated from a monocistronic messenger in vitro. | 1972 | 4350807 | |
| two physically and functionally distinct forms of eukaryotic 40s ribosomal subunits. | 1973 | 4350951 | |
| purification of a messenger-specific initiation factor from ascites-cell supernatant. | 1973 | 4351524 | |
| a physico-chemical sub-grouping of the mammalian picornaviruses. | 1973 | 4351695 | |
| lesions of renal glomeruli in mice with virus-induced diabetes mellitus-like disease. | 1973 | 4351966 | |
| specificity of the control of protein synthesis by haemin. | 1973 | 4351984 | |
| function of phosphorylated ribosomes. the activity of ribosomal subunits phosphorylated in vitro by protein kinase. | 1973 | 4352193 | |
| effects of sonication on physicochemical and biological properties of synthetic double-stranded polyribonucleotides as interferon inducer. | 1972 | 4352302 | |
| evidence for the lack of glycoprotein in the encephalomyocarditis virus particle. | 1973 | 4352952 | |
| further studies on the influence of steroids on viral infection in mice. | certain steroids have been reported to enhance experimental viral infections, whereas others have little or no effect. interference with the interferon system has been suggested as a possible mechanism for the viral infection-enhancing (vie) activity of hormones. in the present study, steroids (prednisolone, progesterone, testosterone) which had no effect on mm virus infection demonstrated vie activity against mayaro virus infection. it is suggested that the vie activity of a hormone may be depe ... | 1973 | 4353541 |
| light and electron microscopic studies of mouse cns after subcutaneous administration of the e and m variants of the encephalomyocarditis virus. | 1973 | 4353899 | |
| bis-basic-substituted polycyclic aromatic compounds. a new class of antiviral agents. 1. bisalkamine esters of fluorenone-, fluorenol-, and fluorenedicarboxylic acids. | 1973 | 4354693 | |
| endonuclease of high specific activity in a purified mouse interferon preparation. | 1973 | 4354948 | |
| immunization of mice with live attenuated encephalomyocarditis virus: local immunity and survival. | mice were vaccinated with an attenuated encephalomyocarditis (emc) virus strain by the intraperitoneal (i.p.) route and by various ways of respiratory administration: aerosol exposure and intratracheal (i.t.) and intranasal (i.n.) instillation. a linear relationship was found between vaccine dose and the resulting serum antibody titer. the effectiveness of the vaccine was determined by measuring the 50% protective doses (ed(50) values) after a lethal challenge with live virulent virus given by t ... | 1973 | 4355137 |
| encephalomyocarditis (emc) virus infection of the mouse aorta. an ultrastructural study. | 1973 | 4355169 | |
| propionin b, an antiviral principle of propionibacteria. | 1973 | 4355824 | |
| role of immunity in viral-induced bacterial superinfections of the lung. | although viral illnesses are predisposing causes for pulmonary bacterial infections, the interrelationships of viral virulence and host immunity to alterations in susceptibility to bacterial infection are incompletely understood. we used two mutant strains of encephalomyocarditis virus (minimally virulent mengo-37a and a highly virulent columbia sk [col-sk]) to investigate these interrelationships. mice that had been immunized to mengo-37a, and nonimmunized controls, were challenged with aerosol ... | 1973 | 4356071 |
| persistent infection of mouse cells with sindbis virus: role of virulence of strains, auto-interfering particles and interferon. | 1973 | 4356681 | |
| the effect of ethidium bromide on l cells and encephalomyocarditis virus replication. | 1973 | 4356683 | |
| specificity of reticulocyte initiation factors for the translation of globin messenger rna. | 1973 | 4356821 | |
| inhibition of protein synthesis directed by added viral and cellular messenger rnas in extracts of interferon-treated ehrlich ascites tumor cells. location and dominance of the inhibitor(s). | 1973 | 4356983 | |
| a comparison of the virus-specific polypeptides of encephalomyocarditis virus, human rhinovirus-1a, and poliovirus. | 1973 | 4357051 | |
| encephalomyocarditis virus activity in mus booduga (gray) in barur village (1961-1962), sagar kfd area, mysore state, india. | 1973 | 4357094 | |
| detection of encephalomyocarditis virus infection in animal cells by gas liquid chromatography. | 1973 | 4357193 | |
| size differences in the ribonucleic acids of feline leukaemia viruses. | 1973 | 4357376 | |
| [antiviral activity of components of echinacea purpurea]. | 1973 | 4358341 | |
| typhoid-paratyphoid (tab) vaccine as interferon inducer in mice. | 1973 | 4358715 | |
| the in vitro effect of cyclophosphamide on col. mm virus replication and interferon production. | 1973 | 4358716 | |
| role of incomplete viruses and interferon in persistent infection of mouse cells with sindbis virus. | 1973 | 4358717 | |
| microtiter hemagglutination-inhibition test for the detection of encephalomyocarditis virus antibodies. | several variables were found to affect the agglutination of sheep erythrocytes by encephalomyocarditis virus. a satisfactory and reliable microtiter hemagglutination-inhibition test is described. | 1974 | 4358861 |
| inactivation of encephalomyocarditis virus in aerosols: fate of virus protein and ribonucleic acid. | after aerosolization at relative humidities of 50% or lower, encephalomyocarditis virus is rapidly inactivated. in this process the protein coat of the virion is damaged. this appears as a loss of hemagglutination activity and loss of affinity for hemagglutination inhibiting antibodies. the ribonucleic acid of the virus retains its infectivity but it becomes susceptible to ribonuclease. it sediments in sucrose gradients when centrifuged at high speed with the same velocity as free infectious rib ... | 1974 | 4358862 |
| a correlation between the buoyant density and the sedimentation coefficient of emc viral polyribosomes. | 1973 | 4359147 | |
| the effect of certain amino acids on reproduction of encephalomyocarditis virus. ii. investigation of the inhibiting effect of l-histidine. | 1973 | 4359174 | |
| genetic influences affecting the occurrence of a diabetes mellitus-like disease in mice infected with the encephalomyocarditis virus. | the m variant of encephalomyocarditis virus produces a diabetes mellitus-like disease in dba/2 mice but not in animals of the c3h strain. fewer than one-third of infected f(1) (dba/2 x c3h) progeny exhibit the disease, whereas the prevalence in backcrosses (f(1) x dba/2, f(1) x c3h) is comparable to the parental inbred strain. thus, the mode of inheritance of the diabetic predisposition appears to be polygenic. dba/2 animals develop striking inflammatory and necrotizing lesions of the islets of ... | 1974 | 4359400 |
| precursor--product relationship of encephalomyocarditis virus-specific polypeptides. comparisons by tryptic peptide mapping. | 1973 | 4359629 | |
| lesions of the islets of langerhans in encephalomyocarditis virus-infected mice with diabetes mellitus-like disease. i. acute lesions. | mice infected with the m variant of the encephalomyocarditis (emc) virus develop lesions of the islets of langerhans associated with a diabetes mellitus-like disease. ultrastructural alterations become evident in capillaries and beta cells at a time when large amounts of virus are present in the pancreatic tissue. although some beta cells become necrotic, degranulation and contraction of intact cells is the prominent lesion. changes in the capillaries appear early in the course of the infection ... | 1974 | 4359734 |
| biochemical and biophysical characterization of calicivirus isolates from pinnipeds. | 1973 | 4359761 | |
| interferon assay based on the inhibition of double-stranded reovirus rna accumulation in mouse l cells. | 1973 | 4360633 | |
| serologic evidence of arbovirus activity in a moose population in alberta. | 1971 | 4361127 | |
| editorial: viruses and arteriosclerosis. | 1974 | 4361469 | |
| new isothiazole derivatives. ii. cytotoxicity and antiviral activity in tissue cultures. | 1973 | 4361627 | |
| oral induction of interferon by a low-molecular-weight compound. | 1974 | 4362004 | |
| [translation of cellular and viral information rna in extracts from cells infected with encephalomyocarditis viruses]. | 1974 | 4362233 | |
| amylase isoenzymes during viral infections of the pancreas and salivary glands. | 1974 | 4362566 | |
| viral infections of the central nervous system. | 1974 | 4362722 | |
| phagocytosis of injured hepatocytes following inoculation with encephalomyocarditis virus. | 1974 | 4363126 | |
| virus-induced diabetes mellitus. ii. relationship between beta cell damage and hyperglycemia in mice infected with encephalomyocarditis virus. | infection of dba 2 male mice with the m variant of encephalomyocarditis virus resulted in a diabetes-like syndrome. histologic examination of the pancreas revealed damage to the beta cells with little involvement of the acinar cells. the severity of the hyperglycemia correlated closely with the degree of beta cell damage. by immunofluorescence, viral antigens could be detected in the beta cells during the first 10 days of the infection. in contrast to the response found in male dba 2 mice, infec ... | 1974 | 4363478 |
| erythrocyte association and interferon production by minute virus of mice. | 1974 | 4363906 | |
| release of the inhibition of messenger rna translation in extracts of interferon-treated ehrlich ascites tumor cells by added transfer rna. | 1974 | 4363942 | |
| antiviral activity of tobacco smoke condensate on encephalomyocarditis infection in mice. | a water-soluble nontumorigenic acidic fraction of tobacco smoke condensate of cigarettes has been found to have antiviral activity against encephalomyocarditis (emc) virus infection in mice. the portion of lower molecular weight was inhibitory to the growth of emc virus, vesicular stomatitis virus, reovirus type 2, vaccinia virus, and poliovirus type 2, but not against adenovirus type 12, in kb cell cultures. the cigarette smoke agent did not induce serum interferon although it protected mice fr ... | 1973 | 4364177 |
| n,n-dioctadecyl-n',n'-bis(2-hydroxyethyl) propanediamine: antiviral activity and interferon stimulation in mice. | cp-20,961, n,n-dioctadecyl-n', n'-bis(2-hydroxyethyl)propanediamine, is an antiviral drug with low acute toxicity in mice. parenteral injection of this compound protected mice against lethal infections with encephalomyocarditis and semliki forest viruses and effectively suppressed pox formation by vaccinia infection. maximal antiviral effects were observed when cp-20,961 was administered 6 to 12 h before infection. an interferon detected in plasma 12 to 20 h after the drug was given appeared to ... | 1973 | 4364178 |
| rna ligase activity in phage-infected bacteria and animal cells. | 1974 | 4364393 | |
| presence of a large poly(rc) tract within the rna of encephalomyocarditis virus. | 1974 | 4364433 | |
| lead aggravates viral disease and represses the antiviral activity of interferon inducers. | lead acetate was administered continuously in the drinking water to cd-1 male mice beginning at 4 weeks of age. an ld(10-20) of the lytic viruses or 300 plaque-forming units of rlv was inoculated intrapertioneally at 6 weeks of age. lead increased the response of the mice to all classes of viruses against which it was tested: an rna picornavirus-encephalomyocarditis (emcv), a dna herpesvirus-pseudoribies, an rna leukemia-virus-rauscher leukemia (rlv), an rna arbovirus b-st. louis encephalitis, a ... | 1974 | 4364644 |
| regulation of protein synthesis during density-dependent growth inhibition of bhk21-13 cells. | 1974 | 4364657 | |
| the rate of polypeptide chain elongation in a cell-free system from krebs ii ascites cells. | 1974 | 4364993 | |
| antiviral effect of interferon covalently bound to sepharose. | interferon, covalently bound to sepharose 4b activated by cyanogen bromide, induces the antiviral state in sensitive cells. the antiviral effect is neutralized by antiserum specific to interferon and is recovered thereafter when the antibody is detached from the interferon by treatment at low ph. binding interferon to sepharose increases the stability of the molecule. it is likely that the interferon molecule acts on the cell receptor without being detached from the beads. however, the data do n ... | 1973 | 4365374 |
| the polypeptide composition of the encephalomyocarditis virus particle. | 1974 | 4365488 | |
| pancreatitis of mice infected with encephalomyocarditis virus. | 1974 | 4365521 | |
| [oligomers of the replicative form of encephalomyocarditis virus rna]. | 1974 | 4365610 | |
| hyporeactivity of tissue cultures. | 1974 | 4365729 |