Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| emesis, radiation exposure, and local cerebral blood flow in the ferret. | we examined the sensitivity of the ferret to emetic stimuli and the effect of radiation exposure near the time of emesis on local cerebral blood flow. ferrets vomited following the administration of either apomorphine (approx 45% of the ferrets tested) or peptide yy (approx 36% of those tested). exposure to radiation was a very potent emetic stimulus, but vomiting could be prevented by restraint of the hindquarters of the ferret. local cerebral blood flow was measured using a quantitative autora ... | 1988 | 3375441 |
| characterization of radiation-induced emesis in the ferret. | forty-eight ferrets (mustela putorius furo) were individually head-shielded and radiated with bilateral 60co gamma radiation at 100 cgy min-1 at doses ranging between 49 and 601 cgy. the emetic threshold was observed at 69 cgy, the ed50 was calculated at 77 cgy, and 100% incidence of emesis occurred at 201 cgy. with increasing doses of radiation, the latency to first emesis after radiation decreased dramatically, whereas the duration of the prodromal period increased. two other sets of experimen ... | 1988 | 3375446 |
| [rabies antibodies in ferrets after a single rabies vaccination]. | 1988 | 3376624 | |
| effects of metabolic blockade on intracellular calcium concentration in isolated ferret ventricular muscle. | tension and intracellular free calcium concentration [( ca2+]i) were measured in isolated ferret papillary muscles. when both anaerobic glycolysis and oxidative phosphorylation were prevented (metabolic blockade), there was a rapid decline of both developed tension and systolic [ca2+]i signals. subsequently, resting tension increased, and after a further delay, resting [ca2+]i also rose. when oxidative metabolism was restarted after a period of metabolic blockade that was sufficient to elevate b ... | 1988 | 3383366 |
| velocity of the creatine kinase reaction decreases in postischemic myocardium: a 31p-nmr magnetization transfer study of the isolated ferret heart. | recovery of postischemic function may be limited by energy synthesis by mitochondria, energy transfer via the creatine kinase reaction, or energy utilization at myofibrils. to identify the limiting step, we defined the relations among oxygen consumption, creatine kinase reaction velocity and cardiac performance in myocardium reperfused following mild, moderate, and severe ischemia. isolated isovolumic ferret hearts were perfused with krebs-henseleit buffer at 37 degrees c. after 30 minutes of co ... | 1988 | 3383370 |
| segregation of on and off afferents to ferret visual cortex. | 1. on-center and off-center cells are found in separate sublaminae of the ferret's lateral geniculate nucleus (lgn). the purpose of these experiments was to determine whether this segregation is maintained in the projection from the lgn to primary visual cortex (area 17). 2. the distribution of the geniculocortical afferents within area 17 was studied by recording in layer iv after cortical neurons were silenced with kainic acid. 3. in 28 radial penetrations made into layer iv of five kainate-tr ... | 1988 | 3385467 |
| electrophysiological effects of amperozide in papillary muscles from ferrets, guinea-pigs and rabbits. | amperozide, a novel psychotropic agent, in concentrations lower than 10 microm caused a homogenous prolongation only of the action potential in both guinea-pig and rabbit papillary muscle. in concentrations greater than or equal to 10 microm, amperozide caused a flattening of the action potential plateau and the later part of the repolarization phase became slower (longer), probably reflecting an impaired repolarizing na-ca exchange current. the overshoot (os) and the rate of rise of the action ... | 1988 | 3387372 |
| effects of enprofylline, theophylline and terbutaline on second inward currents in papillary muscles from ferrets and guinea-pigs. | in ferret and guinea pig papillary muscles enprofylline (10 microm-10 mm) and theophylline (0.1-2 mm) alone or in combination with terbutaline (0.05 microm-0.1 microm) decreased the action potential duration and increased the plateau height, increased the peak force of contraction and facilitated the depolarization-induced automaticity. in voltage clamp, the xanthines alone or in combination with terbutaline increased second inward currents, ica,f and ica,2, but had relatively less effect on the ... | 1988 | 3387373 |
| tissue fluoroacetate residues in prairie dogs dosed with low-level sodium monofluoroacetate. | a total of 83 black-tailed prairie dogs (cynomys ludovicianus) from south dakota were subjected to low-level treatment with sodium monofluoroacetate (compound 1080) in the laboratory (0.01-0.30 mg 1080/kg). the acute oral median lethal dose (ld50) of 1080 administered by oral gavage was established at 0.173 mg/kg. to assay fluoroacetate residues, 8 kinds of tissue from each of 10 prairie dogs dead of low-level 1080 poisoning were analyzed by capillary gas chromatography-mass spectrometry. of the ... | 1988 | 3391967 |
| chordoma in two ferrets. | chordomas, characterized by lobules of vacuolated cells lying in a mucinous matrix, are described in 2 ferrets. this is the first report of this rare tumour of notochordal remnant origin in the ferret. | 1988 | 3392251 |
| differential effects of testosterone, 5 alpha-dihydrotestosterone and oestradiol-17 beta on plasma concentrations of lh in castrated ferrets. | the biological activity of testosterone often depends on the conversion of testosterone within the target cell to an androgenic or oestrogenic metabolite. the purpose of this study was to compare the relative ability of testosterone and two of its metabolites, dihydrotestosterone (dht) and oestradiol, to suppress lh secretion in castrated male ferrets. castrated ferrets were treated with five different doses of steroid by implanting various numbers of s.c. silicone elastomer capsules packed with ... | 1988 | 3392501 |
| evidence implicating aromatization of testosterone in the regulation of male ferret sexual behavior. | we compared the effects of the aromatase inhibitor, 1,4,6-androstatriene-3,17-dione (atd) and castration on the expression of mating behavior in adult male ferrets which were in breeding condition. males implanted sc with silastic capsules containing atd displayed significantly less neck gripping, mounting and intromittive behavior than intact males which received empty capsules, although the atd-induced reductions in behavior were not as large as those seen after castration. atd had no effect o ... | 1988 | 3393606 |
| comparison of mucus flow rate, radiolabelled glycoprotein output and smooth muscle contraction in the ferret trachea in vitro. | 1. the concentration-response curves for rate of mucus output, labelled-glycoprotein output and smooth muscle contraction in response to methacholine, phenylephrine and salbutamol were determined in the ferret trachea in vitro. 2. the potencies of methacholine and phenylephrine are both in order: smooth muscle contraction, glycoprotein output, rate of mucus output. 3. at lower concentrations methacholine is more potent than is phenylephrine on smooth muscle contraction, glycoprotein output and r ... | 1988 | 3395780 |
| substituted benzamides. 1. potential nondopaminergic antagonists of chemotherapy-induced nausea and emesis. | a series of new substituted benzamides has been synthesized and evaluated for dopamine antagonist activity and for antagonism of cisplatin-induced emesis in the dog and in the ferret. it was found that modification of the 2-methoxy substituent of metoclopramide was detrimental to dopaminergic d2 antagonism but not necessarily to antagonism of cisplatin-induced emesis. a number of analogues having a beta-keto, beta-hydroxy, beta-methoxy, beta-imino, or beta-unsaturated alkyloxy substituent instea ... | 1988 | 3397992 |
| partial characterization of a luteal factor that induces implantation in the ferret. | this study was designed to test the hypothesis that ferret corpora lutea (cl) secrete a compound that acts in conjunction with progesterone to induce blastocyst implantation and to identify the chemical nature of this compound. cl and the residual ovarian tissue, obtained predominantly on the ninth day of pseudopregnancy, were extracted with 0.05 m phosphate-buffered saline. the extracts were injected into pregnant ferrets that had been ovariectomized on day 6 of pregnancy and had received silas ... | 1988 | 3401538 |
| ferrets as pets. | 1988 | 3403344 | |
| antigenic and structural characterization of multiple subpopulations of h3n2 influenza virus from an individual. | influenza viruses grown in embryonated chicken eggs frequently possess antigenically distinguishable hemagglutinin (ha) compared to virus from the same source grown in mammalian cell culture. to further investigate the extent of variation among viruses from an individual, viruses were isolated from throat washes collected over a 48-hr period during infection with influenza virus designated a/mem/6/86 (h3n2). viruses were isolated from limit dilutions in eggs and mammalian madin-darby canine kidn ... | 1988 | 3407150 |
| vagally mediated gastric motor and emetic reflexes evoked by stimulation of the antral mucosa in anaesthetized ferrets. | 1. in the urethane-anaesthetized ferret chemical (nacl, naoh or hcl) or mechanical (stroking) stimulation of the gastric antral mucosa evoked a decrease in corpus pressure and inhibition of contractions in the presence of guanethidine, adrenalectomy and sectioned greater splanchnic nerves. 2. the fall in corpus pressure was present following administration of atropine but was abolished by vagotomy. 3. preliminary evidence, using 100 mm-naoh as the stimulus, is presented that the effects on corpu ... | 1988 | 3411476 |
| canine distemper in black-footed ferrets (mustela nigripes) from wyoming. | in september and october 1985, six black-footed ferrets (mustela nigripes) were captured from the only known population, located near meeteetse, wyoming for captive propagation. two days following capture an adult male showed signs of canine distemper and an adult female displayed similar signs 7 days postcapture; these infections were undoubtedly acquired prior to capture. subsequently the four remaining captive black-footed ferrets also developed canine distemper and all eventually died. clini ... | 1988 | 3411697 |
| a plague epizootic in the white-tailed prairie dogs (cynomys leucurus) of meeteetse, wyoming. | surveillance for sylvatic plague (yersinia pestis) was conducted near meeteetse, wyoming (usa) from 24 may to 14 june 1985. ten species of fleas were collected from white-tailed prairie dogs (cynomys leucurus), and from their burrows and associated rodents. five of these flea species and two adult prairie dogs were positive for plague. the progression of this plague epizootic appeared to be slower and the intensity was less than in previous epizootics in other prairie dog colonies. the plague ep ... | 1988 | 3411698 |
| acidosis during early reperfusion prevents myocardial stunning in perfused ferret hearts. | cellular calcium overload figures prominently in the pathogenesis of the contractile dysfunction observed after brief periods of ischemia (myocardial stunning). because acidosis is known to antagonize ca influx and the intracellular binding of ca, we reasoned that acidosis during reperfusion might prevent ca overload and ameliorate functional recovery. we measured developed pressure (dp) and 31p-nuclear magnetic resonance spectra in 26 isovolumic langendorff-perfused ferret hearts. after 15 min ... | 1988 | 3417873 |
| [aplastic anemia in ferrets]. | the present report describes both estrus associated and estrogen induced aplastic anemia in 7 female ferrets. the animals were presented with anemia, anorexia, apathy, melena and subcutaneous hemorrhages. histologically, the animals showed panmyelophthisis and cystic endometrial hyperplasia. | 1987 | 3424362 |
| intracellular calcium levels in phorbol ester-induced contractions of vascular muscle. | intracellular calcium concentration ([ca2+]i) was measured with aequorin in ferret and rat aortic strips contracted with phorbol esters. in ferret aorta, 12-deoxyphorbol 13-isobutyrate 20-acetate (dpba, 1 microm) induced contractions without significantly increasing [ca2+]i, whereas 21 mm k+ induced smaller contractions with a significant rise in [ca2+]i. ca2+-free 2.5 mm ethyleneglycol-bis(beta-aminoethylether)-n,n'-tetraacetic acid (egta)-physiological saline solution (pss) had no effect on dp ... | 1987 | 3425738 |
| ca2+ signals obtained with multiple indicators in mammalian vascular muscle cells. | enzymatically isolated single cells from ferret portal vein were loaded with the fluorescent dyes fura-2 and chlortetracycline. ferret portal vein intact strips were loaded with the luminescent indicator aequorin. at short loading times, fura-2 loading resulted in relatively homogeneous images of labeled cells. at longer loading times, extremely heterogeneous images were obtained that were similar to those produced by chlortetracycline, an indicator recognized to enter calcium-storage organelles ... | 1987 | 3425745 |
| pedal sarcoptes scabiei infestation in ferrets (mustela putorius furo). | 1987 | 3426474 | |
| effects of partial truncal vagotomy on intragastric pressure responses to vagal stimulation and gastric distension in ferrets. | changes in intragastric pressure after dorsal truncal vagotomy, investigated by stimulation of the surviving vagal branches and by step inflation of the stomach, were divided into an early phase lasting five days, and a late phase continuing for at least three months. during the early phase the amplitude of vagal evoked contraction was diminished but the resting pressure and the response to gastric inflation were increased. after the fifth day vagal evoked contractions doubled in amplitude but t ... | 1987 | 3428683 |
| role for prenatal estrogen in the development of masculine sexual behavior in the male ferret. | previous studies have shown that neonatal exposure to testosterone is essential for coital masculinization in male ferrets. in the present experiments, masculine sexual behavior was diminished in male ferrets by prenatal exposure to drugs which inhibited estrogenic stimulation of the brain. similarly timed prenatal treatments with testosterone failed to masculinize the behavior of female offspring. we hypothesize that prenatal exposure of the male ferret to estrogen, derived from the neural arom ... | 1987 | 3428886 |
| quantitation of the secretory cells of the ferret tracheobronchial tree. | the tracheal epithelium of the ferret has few goblet cells while sero-mucous submucosal glands are present in large numbers throughout the length of the trachea and bronchi. the epithelium consists mainly of ciliated cells and of dark cytoplasmic non-ciliated cells that sometimes contain secretory granules. any 'respiratory tract fluid' secreted into the ferret trachea is probably mainly glandular in origin. the epithelium contains neutrophils and a few mast cells and eosinophils. nerve fibres a ... | 1986 | 3429303 |
| enhanced inflammation to brugia malayi microfilariae in ferrets infected with trichinella spiralis. | 1987 | 3437363 | |
| a bony growth of the skull in a ferret. | 1987 | 3437754 | |
| species variation in the coronary collateral circulation during regional myocardial ischaemia: a critical determinant of the rate of evolution and extent of myocardial infarction. | to determine residual flow to ischaemic tissue, which is the primary determinant of the rate of development and ultimate size of the myocardial infarct resulting from coronary artery occlusion, the coronary collateral circulation was quantified during acute myocardial ischaemia in eight species in vivo using the radiolabelled microsphere technique. in each case, a prominent branch of the left coronary artery was ligated, and within 5 min microspheres (141ce labelled, 15 micron diameter) were inj ... | 1987 | 3440266 |
| ultrastructure of the ferret submandibular gland. | submandibular glands of two male and two female adult ferrets were examined using electron microscopy. the secretory endpiece consisted of mucous acini and seromucous demilunes. the acinar cells were filled with mucous granules of moderate electron density. each granule had a fine fibrillar substructure. two types of demilune cells could be identified, based on the differing electron density of their secretion granules. in some cells the granules were more electron-dense than in others. these gr ... | 1987 | 3446664 |
| food intake and struvite crystalluria in ferrets. | four adult, castrated, male ferrets were studied in two similar trials for effects of food intake on variables hypothesized to promote struvite (ammonium, magnesium, phosphate hexahydrate) crystal formation in urine. struvite crystalluria occurred in three of the four ferrets. urine ph (uph) averaged 6.6 for these ferrets. uph in the ferret without crystalluria was 6.0. by simple linear regression analysis, no relationship was found between the amount of food ingested and the urinary concentrati ... | 1987 | 3451569 |
| effects of platelet activating factor on tracheal mucus secretion, on airway mechanics and on circulating blood cells in live ferrets. | 1986 | 3465554 | |
| tissue response to retrograde root fillings in the ferret canine: a comparison of a glass ionomer cement and gutta-percha with sealer. | tissue healing was compared after apicectomy and filling of ferret lower canines with glass ionomer (ketacfil) or gutta-percha/sealer (tubliseal). both materials provoked an inflammatory response after 7 days, but the response to glass ionomer was less severe. the response after 28 days was different. mild inflammation related to the gutta-percha was still present, but no inflammation was found in relation to the glass ionomer. bone infill was quite advanced in all specimens at 28 days but was m ... | 1987 | 3477771 |
| effects of the paf-antagonist cv-3988 on paf-induced changes in mucus secretion and in respiratory and circulatory variables in ferrets. | 1987 | 3479001 | |
| experimental pneumocystis carinii pneumonia in the ferret. | pneumocystis carinii pneumonia (pcp) was provoked in the ferret, mustela pulorius furo, by immunosuppression with daily long-term administration of cortisone acetate, 10-20 mg/kg subcutaneously for 9 to 10 weeks, microscopically p. carinii was observed in the lungs of all 11 treated animals: mild to moderate in five and extensive disease in six. the histopathological features of pcp in the ferret included interstitial pneumonitis, scant mononuclear cell alveolitis, with abundant cysts and tropho ... | 1987 | 3495285 |
| serological studies with influenza a(h1n1) viruses cultivated in eggs or in a canine kidney cell line (mdck). | pairs of influenza a(h1n1) viruses cultivated from the same clinical specimen in canine kidney (mdck) cells or in embryonated hens' eggs can frequently be distinguished by their reactions with monoclonal antibodies to haemagglutinin and with antibodies in ferret or human sera. egg-adapted virus, further passaged in mdck cultures remained "egg-like" in serological characteristics indicating that the differences in their serological reactions were not a direct result of host cell-dependent glycosy ... | 1987 | 3496984 |
| differential production of endogenous pyrogen by human peripheral blood leucocytes following interaction with h3n2 or h1n1 influenza viruses of differing virulence. | fever and other constitutional effects of influenza (headache, myalgia, listlessness, nausea, shivering, anorexia and depression) result from liberation of endogenous pyrogen (ep) from phagocytes. these effects are milder for recent h1n1 influenza virus isolates than for h3n2 strains. interaction with human peripheral blood leucocytes in vitro showed that h1n1 strains, a/ussr/90/77 and a/fiji/15899/83, elicited significantly less ep (as assessed by the rabbit pyrogen assay) than two virulent clo ... | 1987 | 3504218 |
| genetics of cold-adapted b/ann arbor/1/66 influenza virus reassortants: the acidic polymerase (pa) protein gene confers temperature sensitivity and attenuated virulence. | the cold-adapted b/ann arbor/1/66 influenza virus (ca b/aa/1/66) expresses temperature-sensitive (ts), cold-adapted (ca) and attenuation phenotypes. reassortants which inherit one or more genes from ca b/aa/1/66 and all other genes from a virulent, wild-type influenza virus, b/houston/1732/76, were produced and evaluated in order to identify the gene(s) responsible for the ts, ca and attenuation phenotypes. only reassortants which inherited the pa gene from ca b/aa/1/66 expressed the ts phenotyp ... | 1987 | 3504545 |
| biochemical and radioautographic analysis of estrogen-inducible progestin receptors in female ferret brain and pituitary: correlations with effects of progesterone on sexual behavior and gonadotropin-releasing hormone-stimulated secretion of luteinizing hormone. | cytosolic binding molecules for the synthetic progestin [3h]r5020, were isolated in vitro from several brain regions including preoptic area/anterior hypothalamus, mediobasal hypothalamus, medial amygdala and parietal cortex as well as the pituitary gland of ovohysterectomized female ferrets. binding of [3h]r5020 to cortical cytosols was saturable, of high affinity (apparent dissociation constant of 2.0 nm), and was steroid specific. pretreatment of ferrets with a silastic capsule containing est ... | 1986 | 3516305 |
| combined light and electron microscope immunocytochemical localization of scattered peptidergic neurons in the central nervous system. | a pre-embedding immunocytochemical technique is described for combined light and electron microscope study of peptidergic neurons in the central nervous system. the protocol is especially designed to overcome the sampling problems inherent in electron microscope study of structures, such as luteinizing hormone-releasing hormone (lhrh) neurons, that are scattered individually across large brain regions. the fixation methods outlined for several mammalian species include immersion and vascular per ... | 1986 | 3518390 |
| variation among species in the endocrine control of mammary growth and function: the roles of prolactin, growth hormone, and placental lactogen. | prolactin, growth hormone, and placental lactogen form a family of structurally related hormones, which may have evolved from a common ancestral peptide. prolactin and growth hormone are present in all mammals, but the biological activity associated with placental lactogen has been detected in only some groups. attempts to detect placental lactogen using bioassay and radioreceptor assay are reported and have been unsuccessful in an insectivore (the shrew), a bat, an edentate (the armadillo), a l ... | 1986 | 3519707 |
| development of murine monoclonal antibodies to pneumocystis carinii. | relatively little is known about the antigenic structure of pneumocystis carinii and the immunopathogenesis of pneumonitis caused by p. carinii. to begin to define the antigenic character of the surface of this organism, we have produced murine monoclonal antibodies that react with the surface of p. carinii (obtained from rats), as detected by immunofluorescence and immunoelectron microscopy. immunoblot analysis revealed that the six antibodies described in this report bound an antigen with an a ... | 1986 | 3522758 |
| the ferret: a new model of oral ethanol injury involving the liver, bone marrow, and peripheral blood lymphocytes. | we have developed a model of oral ethanol ingestion in the ferret by providing a complete liquid diet in which 21% of the total caloric intake is given as ethanol. after 3 weeks of ethanol treatment, migration inhibitory factor activity from ferret lymphocytes was significantly decreased when compared to animals fed a dextrose-substituted, identical liquid diet. lymphocyte blastogenesis in response to the mitogen, phytohemagglutinin, was also decreased after 6 weeks of ethanol ingestion. histopa ... | 1986 | 3526951 |
| developmental changes in glycoconjugate secretion by ferret tracheas. | surface epithelium and submucosal glands of the ferret trachea undergo extensive postnatal development. this study examined developmental changes in rates of release and types of high molecular weight glycoconjugates secreted by explanted ferret tracheas. digestion with bovine testicular hyaluronidase separated the high molecular weight glycoconjugates into two types, hyaluronidase-resistant mucins and hyaluronidase-susceptible glycosaminoglycans. release rates were measured under unstimulated c ... | 1986 | 3532888 |
| evidence for dopaminergic regulation of prolactin and a luteotropic complex in the ferret. | the role of dopaminergic agents in prolactin (prl) release and the luteotrophic role of prl and luteinizing hormone (lh) were investigated in pseudopregnant female ferrets. a single injection of the dopamine antagonist pimozide (0.63 mg/kg) resulted in a tenfold elevation of plasma prl in anestrous females. subcutaneous injection of pimozide on alternate days from day 2 through day 16 of pseudopregnancy elevated both prl and progesterone levels. daily treatment with the dopamine agonist 2 alpha- ... | 1986 | 3539212 |
| bacterial adherence to the upper respiratory tract of ferrets infected with influenza a virus. | a ferret model was used to study bacterial adherence in animals with influenza. ferrets were inoculated intranasally with influenza a3/hong kong/1/68 virus. antiviral serum antibodies were apparent by day 5. on days 3, 5, 7, 9, and 11, three virus-inoculated and two uninoculated controls were anesthetized, exsanguinated, and decapitated, and the lower jaw was removed. each animal was inoculated intranasally with a 1-ml suspension containing 20 mg (dry wt) of either 3h-labeled staphylococcus aure ... | 1987 | 3554259 |
| spatial response properties of acoustically responsive neurons in the superior colliculus of the ferret: a map of auditory space. | extracellular single-unit recordings were made from auditory neurons in the superior colliculus of ferrets anesthetized with either a neuroleptic or a combination of barbiturate with paralysis. the response properties of these neurons were studied using white-noise bursts presented under free-field conditions in an anechoic chamber. auditory neurons were found throughout the intermediate and deep layers of the superior colliculus. all neurons were spontaneously active, the rates of discharge var ... | 1987 | 3559694 |
| a cage for the ferret. | a cage for ferrets is described that consists of a plastic box with a metal sliding-grill top and metal front lattice. it contains a new feeding system using dishes that can be removed without opening the cage. the cages are kept in mobile racks and are commercially available. | 1987 | 3560863 |
| intracellular [ca2+] related to rate of force development in twitch contraction of heart. | the relation between the rate of rise of tension (df/dt) and intracellular free ca2+ concentration ([ca2+]i) during twitch contraction was investigated in mammalian ventricular myocardium. [ca2+]i was assessed from luminescence emitted by ferret papillary muscles microinjected with the calcium-regulated photoprotein aequorin. evidence was found that during the phase of rising tension following maximum positive df/dt, there was an approximately linear relationship between df/dt at a given instant ... | 1987 | 3565592 |
| toxicity of thiram (tetramethylthiuram disulfide) to mink and european ferrets. | 1987 | 3567399 | |
| involvement of gastrointestinal mechano- and intestinal chemoreceptors in vagal reflexes: an electrophysiological study. | the role of gastrointestinal mechanoreceptors and intestinal chemoreceptors in the genesis of vago-vagal reflexes was assessed by recording single vagal efferent fibre discharge in the urethane-anaesthetized ferret during procedures known to activate discrete populations of gastrointestinal afferent fibres. distension of the stomach, duodenum and jejunum was used to activate mechanoreceptors while perfusion of the intestinal loops with various chemical solutions was used to activate mucosal chem ... | 1987 | 3571829 |
| behavioral correlates of hippocampal type 2 theta in the rat. | previous research has indicated that there are two types of theta activity which can be recorded from the hippocampus in most rodents. one type (type 1) of theta is correlated with voluntary movements while the second (type 2) occurs during immobility. a third waveform termed lia (large amplitude irregular activity) occurs during more automatic behaviors, e.g., grooming, shivering or immobility. in the rabbit and guinea pig type 2 theta can readily be elicited in unrestrained animals. however, t ... | 1987 | 3575499 |
| a study of spontaneous sexual maturation of the female ferret. | although ferrets are long-day breeders, females reared exclusively in nonstimulatory short days will undergo spontaneous sexual maturation by 30-50 wk of age. in the following report, this spontaneous sexual maturation of ferrets was studied to determine mechanisms regulating sexual maturation in nonstimulatory photoperiods. study of ovariectomized females treated with low, constant levels of estradiol suggest that a marked decrease in the efficacy of estradiol to inhibit luteinizing hormone sec ... | 1987 | 3580455 |
| developmental patterns of thyroid hormones and testosterone in ferrets. | plasma levels of thyroxine (t4) and triiodothyronine (t3) were measured in male and female ferrets at regular intervals between postnatal day 20 and 150 as well as in adult animals. in addition, testosterone level in male ferrets was measured. all hormones showed characteristic developmental patterns. there is a t4 maximum prior to a t3 maximum in subadult animals which in both cases surpasses adult levels. testosterone level shows a different developmental pattern. there is an outstanding peak ... | 1987 | 3583228 |
| retinal decussation patterns in pigmented and albino ferrets. | the decussation patterns of retinal ganglion cells in adult pigmented and albino ferrets were determined from the distribution of cells labelled after large unilateral injections of horseradish peroxidase into the visual pathway, involving the lateral geniculate nucleus and fibres of passage to the superior colliculus. about 6000 retinal ganglion cells project ipsilaterally in pigmented ferrets compared with only about 1500 in albino ferrets. in both strains, the vast majority of these cells (99 ... | 1987 | 3587608 |
| the effect of vasoactive intestinal peptide on smooth muscle tone and mucus secretion from the ferret trachea. | the effect of vasoactive intestinal peptide (vip) was examined on the smooth muscle contraction and mucus secretion produced by methacholine and phenylephrine in the ferret whole trachea in vitro. vip (0.5 to 800 nm) produced a concentration-dependent relaxation of the ferret trachea contracted by methacholine (1 microm) and phenylephrine (10 microm). the concentration-response curves for methacholine- and phenylephrine-induced contractions were both shifted to the right by vip (0.1 microm). met ... | 1987 | 3594072 |
| use-dependence of ryanodine effects on postrest contraction in ferret cardiac muscle. | during an investigation of the effect of ryanodine on contractions in cardiac muscle, it was found that long rest periods removed all or most of the drug's effect. therefore, we studied the kinetics of block development and recovery from block produced by low concentrations of ryanodine (1-100 pm) on the postrest contractions of ferret papillary muscle. at 100 pm, ryanodine depressed steady-state contraction amplitude slightly (4.2 +/- 1.1% mean +/- sem, n = 10) but strongly inhibited (40-80%) t ... | 1987 | 3594740 |
| investigation of the vagally induced changes in transmural potential difference in the ferret jejunum in vivo. | this study was designed to determine whether the non-cholinergic, non-adrenergic rise in transmural potential difference (pd), induced by vagal nerve stimulation is an efferent effect or one caused by the antidromic stimulation of afferent fibers. unilateral left supranodose vagotomy was performed, which caused degeneration of efferent fibers within the vagus nerve, leaving the nodose ganglion, and consequently afferent cell bodies, undamaged. after stimulating the unoperated nerve there was an ... | 1987 | 3598050 |
| contribution of auditory cortex to sound localization by the ferret (mustela putorius). | ferrets were tested in a semicircular apparatus to determine the effects of auditory cortical lesions on their ability to localize sounds in space. they were trained to initiate trials while facing forward in the apparatus, and sounds were presented from one of two loudspeakers located in the horizontal plane. minimum audible angles were obtained for three different positions, viz., the left hemifield, with loudspeakers centered around -60 degrees azimuth; the right hemifield, with loudspeakers ... | 1987 | 3598629 |
| isolation of an atypical rotavirus causing diarrhea in neonatal ferrets. | a rotavirus was isolated from neonatal ferrets (mustela putorius furo) with diarrhea at a large commercial farm. this virus is classified as an atypical rotavirus, probably belonging to the group c rotaviruses. this classification is based on the lack of the rotavirus group a common antigen and on its distinct dsrna electropherotype pattern in polyacrylamide gels. the diarrheal disease was reproduced experimentally in neonatal ferrets. | 1987 | 3599884 |
| clinical, functional and pathologic changes associated with a case of dilatative cardiomyopathy in a ferret. | 1987 | 3599892 | |
| chondrosarcoma of the tail of ferrets (mustela putorius furo). | 1987 | 3603966 | |
| peripheral lymphedema in ferrets infected with brugia malayi. | this study examines the production and persistence of peripheral lymphedema in ferrets experimentally infected with brugia malayi. in 14 of 18 ferrets inoculated 2 or more times with infective larvae, lymphedema developed in the inoculated paw or paw and lower leg. in 5 of these ferrets lymphedema had persisted for 8 to 18 months at the time of necropsy. lymphedema rarely was observed following a single inoculation of larvae or in microfilaremic ferrets. the results suggest that the ferret may b ... | 1987 | 3605495 |
| the early development of the heart of tupaia belangeri, with reference to other mammals. | the development of the heart of tupaia belangeri from the first endothelial-lined lumina to the cardiac loop is described in 20 embryos with 2 to 14 somites, from ontogenetic days 11 and 12. bilateral endocardial tubes transporting blood are found in the 8-somite embryo; in the middle cardiac plate, angioblasts and angiocysts are located between them. in the 9-somite embryo, formation of the cardiac loop has started, the endocardial tubes approach each other closely, most of the angiocysts have ... | 1987 | 3605650 |
| source of cholinergic input to ferret visual cortex. | the source of cholinergic input to ferret visual cortex was investigated with a combination of retrograde transport of horseradish peroxidase and choline acetyltransferase immunohistochemistry. cholinergic projections to ferret visual cortex arise from basal forebrain cells in the septum, diagonal and nucleus basalis magnocellularis; the largest contribution comes from cells in the caudal part of the nucleus basalis magnocellularis. there is no discernible source in the brainstem. | 1987 | 3607467 |
| factors affecting preconditioning of trichinella spiralis nativa larvae in musculature to low temperatures. | the influence of preconditioning temperature, length of the preconditioning period, host and age of the infection on the survival of trichinella spiralis nativa larvae in musculature to low temperature refrigeration was investigated. dogs, foxes, ferrets, mink and guinea pigs were infected with a t. spiralis nativa isolate, killed at various times postinfection, preconditioned at temperature of -10 degrees c, -15 degrees c or -20 degrees c for varying periods of time prior to low temperature ref ... | 1987 | 3607648 |
| stretch-induced membrane depolarization in ferret trachealis smooth muscle cells. | we determined the effects of increasing the length of the ferret trachealis muscle on smooth muscle membrane potentials recorded on successive impalements by microelectrodes. the preparation included the paratracheal ganglion nerve plexus as well as trachealis muscle. with sustained increases in muscle length over the range 0.5-0.8 to 1.2 maximal length (lmax), depolarization occurred, which was related to the amplitude of the length increase. membrane depolarizations were also evoked after stre ... | 1987 | 3610928 |
| intracisternal protein in the type ii pneumocyte of the ferret, guinea pig, and mongrel dog. | an intracisternal protein in the type ii pneumocyte of the ferret, guinea pig, and mongrel dog was examined by light and electron microscopy and morphometry. the basic pattern of layering in this membrane-bound, ribosome-studded structure (cisternal body) was visualized in cross section as dense layers separated by approximately 0.1 micron with seven fine layers between. in all species the central fine band of the seven was occasionally more prominent than the other six. in the guinea pig the se ... | 1986 | 3611844 |
| uterine luminal proteins during the preimplantation period in the ferret. | the pattern of synthesis of uterine luminal proteins during the 6-day preimplantation period of the ferret has been analyzed by polyacrylamide gel electrophoresis and fluorography. the results demonstrate that several classes of protein, in particular those of molecular weights of 75,000, 58,000, 50,000, 18,000, and 8,000, are actively synthesized and appear in the uterine lumen during this period. quantitative changes in the amount of radioactivity incorporated by specific proteins as viewed on ... | 1987 | 3612055 |
| use of steroids and a long-acting vasoconstrictor in the treatment of postintubation croup. a ferret model. | there is little in the literature to support recommendations for the use of steroids and vasoconstrictors in the treatment of postintubation croup. we developed a ferret model to study this condition. ninety-eight ferrets were used in these experiments, which were undertaken to evaluate the efficacy of steroids and/or a long-acting vasoconstrictor, to develop dose-response curves for dexamethasone sodium phosphate if it proved efficacious, and to evaluate the possible synergistic effects of comb ... | 1987 | 3620146 |
| assessment of techniques for preventing glycolysis in cardiac muscle. | studies of myocardial function during ischaemic or anoxia would be assisted if it were possible to inhibit glycolysis completely and reversibly. three methods of preventing glycolysis in isolated perfused ferret hearts were studied: (a) the removal of glucose from the perfusate followed by manoeuvres designed to deplete glycogen stores, (b) the use of 2-deoxyglucose, and (c) the use of iodoacetate. the rate of glycolysis before and after applying the three methods was assessed by measuring lacta ... | 1986 | 3621285 |
| correlation of force-length area with oxygen consumption in ferret papillary muscle. | the ventricular systolic pressure-volume area correlates well with myocardial oxygen consumption. however, in isolated muscle preparations, there are experimental data based on both mechanical and energetic measurements that suggest that the pressure-volume area concept may not obtain. in the present study, force-length area, the analog of pressure-volume area for a linear muscle, was examined in the ferret papillary muscle preparation under a wide range of loading conditions. there were two maj ... | 1987 | 3621495 |
| locus of hypoxic vasoconstriction in isolated ferret lungs. | to determine whether hypoxic pulmonary vasoconstriction (hpv) occurs mainly in alveolar or extra-alveolar vessels in ferrets, we used two groups of isolated lungs perfused with autologous blood and a constant left atrial pressure (-5 torr). in the first group, flow (q) was held constant at 50, 100, and 150 ml.kg-1 x min-1, and changes in pulmonary arterial pressure (ppa) were recorded as alveolar pressure (palv) was lowered from 25 to 0 torr during control [inspired partial pressure of o2 (pio2) ... | 1987 | 3624150 |
| intracellular neutral carrier-based ca2+ microelectrode with subnanomolar detection limit. | in intracellular electrolyte solutions a ca2+-selective microelectrode based on the synthetic electrically neutral carrier n,n,n',n'-tetracyclohexyl-3-oxapentanediamide (eth 129) shows an improved detection limit when compared with the so far widely used ca2+ microelectrodes based on the neutral carrier eth 1001. detection limits are found at pca = 9.2 in ca2+ buffers containing an intracellular background of k+ (125 mm). selectivity studies in mixed solutions show a preference of ca2+ over na+ ... | 1987 | 3627942 |
| differential effects of reoxygenation on intracellular calcium and isometric tension. | we used the bioluminescent ca2+ indicator, aequorin to record intracellular calcium transients during reoxygenation of hypoxic ferret ventricular muscle in order to determine whether alterations in the amplitude and time course of isometric contraction are mediated by changes in [ca2+]i. papillary muscles less than or equal to 1 mm in diameter were removed from the hearts of male ferrets and perfused with a bicarbonate-buffered physiologic salt solution at 30 degrees c. muscles were stimulated t ... | 1987 | 3627961 |
| the inhibitory enteric nerves of the gastric corpus and the ileum of the ferret. | 1987 | 3628313 | |
| oestrogen toxicity in the ferret. | 1987 | 3651327 | |
| evidence that a decrease in testosterone negative feedback mediates the pubertal increase in luteinizing hormone pulse frequency in male ferrets. | neuroendocrine mechanisms regulating luteinizing hormone (lh) secretion during puberty were investigated in intact male ferrets and ferrets castrated at 8 wk of age that received s.c. implants of either empty or testosterone-filled silastic capsules. to synchronize puberty onset among individuals, ferrets were exposed to short days between 8 and 16 wk of age, and then transferred to long days. testis growth began in intact ferrets soon after photoperiod transition. blood samples were obtained at ... | 1987 | 3651552 |
| platelet activating factor stimulates secretion of mucin by explants of rodent airways in organ culture. | platelet activating factor (paf; 1-o-alkyl-2-0-acetyl-sn-glycero-3-phosphocholine-3-phosphocholine) a potential mediator of anaphylaxis, stimulates secretion of mucin by explants of trachea from four separate rodent species (guinea pig, rat, rabbit, ferret) in organ culture. enhanced secretion is not a result of cell damage or release of histamine by cells within the explants (e.g., platelets). it is inhibited by equimolar concentrations of the potent paf-receptor antagonist, ro 19-3704. paf pro ... | 1987 | 3653044 |
| autoradiographic studies of the distribution of 35sulfate label in ferret trachea: effects of stimulation. | na2(35)so4 is among the common isotopic mucin precursors used to label airway secretory cells and monitor their active discharge in response to drugs. previous work has established that 35s is taken up by multiple cell types in the trachea, yet there is no direct evidence linking 35s release with secretory activity by any specific cell type. in this study, we have used autoradiography to identify the sites of uptake and release of 35s in ferret trachea. confirming work performed in other species ... | 1987 | 3653046 |
| hyperadrenocorticism in a ferret. | a 7-year-old adult male ferret had progressive hair loss that was bilaterally symmetric. also clinically evident were severe dehydration, polydipsia, muffled heart sounds, weak femoral pulses, hepatomegaly, lethargy, weakness, temporal muscular atrophy, dyspnea, and weakness. the blood profile of the ferret indicated profound leukopenia, eosinopenia, and high phosphorus, bun, creatinine, and potassium concentrations, as well as high aspartate transaminase activity; the albumin concentration was ... | 1987 | 3654302 |
| ultrastructure of the ferret parotid gland. | parotid glands of two male and two female adult ferrets were examined using electron microscopy. the acinar cells contained an abundance of rough endoplasmic reticulum, an extensive golgi complex, and electron-dense granules with a denser spot in each. the acinar lumen and the intercellular canaliculi were lined by a large number of prominent microvilli. the intercalated ducts were long and in their proximal part the cells contained small electron-dense granules, whereas the distal portions were ... | 1987 | 3654374 |
| intracellular ph in sheep purkinje fibres and ferret papillary muscles during hypoxia and recovery. | 1. the changes of intracellular ph (phi) of papillary muscles from ferret and purkinje fibres from sheep heart during hypoxia and recovery from hypoxia were recorded with ph-sensitive micro-electrodes filled with neutral h+ carrier. 2. hypoxia was produced by replacement of o2 with n2 in the superfusing solutions. when oxidative phosphorylation was prevented, developed tension fell within 20 min to about 16 and 21% of its control value for papillary muscle and purkinje fibres respectively. on re ... | 1987 | 3656122 |
| the role of the sarcoplasmic reticulum in the response of ferret and rat heart muscle to acidosis. | 1. the photoprotein aequorin was micro-injected into papillary muscles from the right ventricle of ferrets and rats. tension and aequorin light (a function of intracellular [ca2+]) were monitored. 2. in stimulated ferret papillary muscles, increasing the [co2] of the bicarbonate-buffered superfusate from 5% (ph 7.35) to 20% (ph 6.8) led to a rapid decrease of developed tension, with no significant change in the size of the intracellular ca2+ transient which accompanies contraction. there was the ... | 1987 | 3656151 |
| modulation of the vagal drive to the intramural cholinergic and non-cholinergic neurones in the ferret stomach by baclofen. | 1. in the urethane-anaesthetized ferret vagotomy (cervical and abdominal) and hexamethonium both produced an increase in gastric corpus pressure after treatment with atropine and guanethidine, section of the greater splanchnic nerves and adrenalectomy. 2. the pressure increase was due to an interruption of a tonic vagal drive to the intramural non-adrenergic, non-cholinergic inhibitory neurones. 3. the gabab receptor agonist baclofen (8 mg/kg s.c.) produced an increase in gastric pressure and en ... | 1987 | 3656193 |
| features of developing ferret tracheal epithelium: ultrastructural observations of in vivo and in vitro differentiation of ciliated cells. | ultrastructural features of the developing, surface epithelium of ferrets from birth to 28 days of age were characterized. progressive ciliogenesis in vivo was observed, beginning with cells covering the membranous portion of the trachea. emerging cilia appeared in ultrathin sections and by scanning electron microscopy at sites correlating with accumulation of integral membrane particles seen in freeze-fracture preparations. two patterns of ciliogenesis were observed: (1) the random emergence of ... | 1987 | 3665853 |
| in vitro binding and utilization of lipoproteins by luteal cells from ferrets treated with dopaminergic drugs during pseudopregnancy. | the effects of administration of dopaminergic drugs in vivo on the binding and utilization of lipoproteins for progesterone synthesis in vitro by ferret luteal cells were investigated. pimozide, a dopamine antagonist, and bromoergocriptine (cb-154), a dopamine agonist, were administered to pseudopregnant ferrets to alter prolactin (prl) concentrations daily beginning the day after ovulation. the control group received the vehicle solution only. corpora lutea taken on day 13 after ovulation were ... | 1987 | 3666406 |
| role of milk-derived igg in passive maternal protection of neonatal ferrets against influenza. | neonatal ferrets are protected against infection with influenza virus by colostral and milk-derived anti-influenza virus igg after suckling on an immune mother. the levels of igg elicited and then transmitted to neonates were similar when mothers were immunized by either live infection or killed vaccines. maternal anti-influenza virus iga and igm appears not to cross the neonatal gut epithelium although both are present in maternal serum and milk. | 1987 | 3668509 |
| evidence for an extra-abdominal site of action for the 5-ht3 receptor antagonist brl24924 in the inhibition of radiation-evoked emesis in the ferret. | recent studies have implicated 5-ht3(5-ht-m) receptors in the genesis of retching and vomiting evoked by antineoplastic agents. such receptors have so far only been located peripherally, notably on the vagus. therefore, the effects of bilateral abdominal vagotomy and antagonism of 5-ht3 receptors have been investigated on retching and vomiting induced by radiation. the gastrokinetic substituted benzamide brl24924, (beecham pharmaceuticals) which has 5-ht3 receptor antagonist properties, was used ... | 1987 | 3670559 |
| reproductive state and motor activity in female ferrets. | the pattern of motor activity in female ferrets (mustela putorius furo) housed in cages mounted upon rocker platforms was followed under conditions of short-(8 hr) and long-(16 hr) day illumination. a distinct diurnal rhythm was evident that remained unchanged after lesioning of the anterior hypothalamus. the level of activity did not differ between animals kept under short days and long days, between anoestrous and oestrous females, or during the development or waning of oestrus. ovariectomy di ... | 1987 | 3671541 |
| [halothane intubation anesthesia during controlled respiration in ferrets]. | 1987 | 3673292 | |
| the ferret as a model for endogenous synthesis and metabolism of n-nitrosamines. | we have begun to evaluate the ferret as a model for studying gastric nitrosation and nitrosamine metabolism. jugular cannulation allows convenient dosing and sampling of blood, and this technique has been used to study clearance of n-nitrosodimethylamine (ndma) after intravenous, intraperitoneal and intragastric administration. ndma metabolism can be inhibited by 4-methylpyrazole for up to 24 h; the accumulation of endogenously-synthesized ndma can therefore be observed in animals following pret ... | 1987 | 3679351 |
| comparative sensitivities to antimicrobial agents of campylobacter pylori and the gastric campylobacter like organism from the ferret. | 1987 | 3680554 | |
| cystic mucinous hyperplasia in the gallbladder of a ferret. | an 8-year-old male ferret had icterus, hepatomegaly and an enlarged gallbladder. microscopically, the gallbladder had numerous mucinous cysts and papillary hyperplasia of the mucosa, consistent with a diagnosis of cystic mucinous hyperplasia. no previous published reports of this condition in ferrets were found. | 1987 | 3680648 |
| inhalation toxicity of ribavirin in suckling ferrets. | ribavirin is a broad-spectrum antiviral agent useful for treatment of infants. to study the effects in developing mammalian lungs, four groups of jill ferrets and their litters were given whole body inhalation exposures for 6 h a day for 10 or 30 consecutive days to concentrations of 0 (vehicle control), 162, 355 or 620 mg/m3. the effects, including special lung observations in suckling kits, were evaluated after exposures at weaning and at puberty. first the high dose, then the mid dose jills d ... | 1987 | 3680851 |
| the actions of methacholine, phenylephrine, salbutamol and histamine on mucus secretion from the ferret in-vitro trachea. | methacholine, phenylephrine and histamine produced highly significant and salbutamol significant increases in the rate of mucus secretion from the ferret trachea. methacholine, phenylephrine and histamine all produced highly significant increases in the rate of output of lysozyme, but the concentration of lysozyme in the mucus was significantly increased only by phenylephrine. salbutamol produced no significant change in the output of lysozyme, and the concentration of lysozyme in the mucus was ... | 1987 | 3687600 |
| the effects of peptides and mediators on mucus secretion rate and smooth muscle tone in the ferret trachea. | the effects of a number of peptides and mediators were measured on the secretion rate of tracheal mucus and tracheal smooth muscle tone in the ferret in vitro whole trachea. the comparison of secretion rate and smooth muscle tone, measured simultaneously in the same preparation, shows that there are wide differences in sensitivity between the two systems; there appears to be no relationship between mucus volume output and smooth muscle contraction. the comparison of mucus secretion rate and glyc ... | 1987 | 3687601 |
| spatial properties of neurones in the lateral geniculate nucleus of the pigmented ferret. | we used quantitative electrophysiological techniques to study the spatial properties of single units recorded extracellularly in the lateral geniculate and perigeniculate nuclei of the adult pigmented ferret. all neurones examined had approximately circular receptive fields, whose central regions gave responses antagonistic to those elicited from the surrounds. we presented sinusoidally modulated grating patterns, either drifting or counterphased, to obtain spatial frequency tuning curves, contr ... | 1987 | 3691695 |