Publications

the cerebrospinal fluid: current concepts of its formation.	until recently it has been generally accepted that the choroid plexuses are the major source of the cerebrospinal fluid (csf). however, data now indicate that significant contributions to the csf are made at extrachoroidal sites. csf production studies and 24na transport studies in normal and plexectomized rhesus monkeys supportive of substantial extrachoroidal csf formation will be presented. although the exact mechanisms of csf formation remain to be defined, ultrafiltration is probably involv ...	1976	174480
cyclic amp in developing muscle of the rhesus monkey: effect of prostaglandin e.	cyclic amp levels, measured by a competitive protein-binding assay and by a prelabeling technique with adenine-14 c, were determined on fetal, infant, and adult heart, diaphragm, and skeletal muscle of the rhesus monkey (macaca mulatta); the effect of pge on cyclic amp accumulation was also studied. the levels of cyclic amp were higher in the 3 types of muscle from 150-day fetuses (91% of term) than in adult muscles and even higher at 78-100 days fetal age, and histological evidence indicated th ...	1976	174762
control of glycolysis in skeletal muscle from fetal rhesus monkeys.	in our studies of metabolic control mechanisms in skeletal muscle from rhesus fetus we have determined the tissue levels of the metabolic intermediates and cofactors of the glycolytic pathway and have calculated the mass-action ratios for each reaction. skeletal muscle from rhesus fetuses (macaca mulatta), 90-155 days of gestational age, and from adult rhesus monkeys was used in these experiments. the apparent equilibrium constants for hexokinase and phosphofructokinase (pfk) in these tissues we ...	1976	175343
cells in regions of rhesus monkey brain and pituitary retain radioactive estradiol, corticosterone and cortisol differentially.		1976	175885
cyclic amp phosphodiesterase activity in fetal and adult muscle of the rhesus monkey.		1976	176071
recovery of herpes simiae (b virus) from both primary and latent infections in rhesus monkeys.	the suspected ability of herpes simiae (b virus) to persist in a latent form has been confirmed in rhesus monkeys. the virus was recovered from primary oral lesions of 2 young monkeys and again, 6 months after disappearance of symptoms, from cultures of gasserian ganglia taken from the same individuals. b virus was identified by its effects in vivo and in vitro and in cross neutralization tests with antisera to reference b virus and herpes simplex virus. tests showed that the same virus was pres ...	1975	177038
antigenic characterization of intermediate adenovirus 14-11 strains associated with upper respiratory illness in a military camp.	an unusual variant of adenovirus (av) 11 was isolated from throat and rectal swabs from six persons with upper respiratory illness in a spanish military camp in march 1969. the same strain was serologically related to the upper respiratory illness of seven other men among 25 sample cases studied in detail. after strain purification, the virus was grouped as an av by standard biological tests; it possessed the usual titers of group-specific hexon antigen but only low hemagglutinin titers (1:4 to ...	1976	177365
multiple testing for the detection of b virus antibody in specially handled rhesus monkeys after capture from virgin trapping grounds.	eight groups of rhesus monkeys totaling over 1,000 animals were captured in the virgin trapping grounds of jammu and kashmir, india. individual caging and special handling technics were utilized to prevent cross-contamination during capture, holding, and subsequent shipment to quarantine facilities in the united states. immediately following the arrival of the monkeys, 5 consecutive blood samples were obtained at approximately 2-wk intervals, and the sera were rested for neutralizing antibody ag ...	1976	177807
characterization of the plasma lipoproteins and apoproteins of the erythrocebus patas monkey.	patas monkey lipoproteins were fractionated into four distinct classes by a combination of ultracentrifugation and geon-pevikon block electrophoresis and characterized with respect to their chemical and physical properties. very low density lipoproteins (vldl) were isolated at d is less than 1.006, were triglyceride rich, and were in the size range 300-850 a. they were similar in apoprotein content to the vldl of man, dog, and swine. the patas monkey low density lipoprotein referred to as ldl-i ...	1976	178359
comparative sensitivity of the bgm cell line for isolation of enteric viruses.	the bgm line of african green monkey kidney cells was less sensitive than primary rhesus monkey kidney cells or human fetal diploid kidney cells for isolation of certain echoviruses and adenoviruses from fecal specimens.	1976	178630
maturation in vitro of oocytes recovered from prepubertal rhesus monkeys.		1976	178865
the nonhuman primates as models for studying human atherosclerosis: studies on the chimpanzee, the baboon and the rhesus macacus.	there is no dearth of experimental techniques for producing the hyperlipoproteinemia resulting in atherosclerotic complications and for myocardial infarction in the non human primates. most of the recent experiments which have given information of great value have been studied with relatively expensive animals for a long period of time up to 6-7 years. it is evident that no animal model perfectly duplicates the human disease or satisfies all desirable requirements. the chimpanzees, representativ ...	1976	179299
effective antiviral prophylaxis and therapy by systemic application of human interferon in immunosuppressed monkeys.	rhesus monkeys treated with antilymphocytic globulin were infected with vaccinia virus or with medical lake macaque herpesvirus. at the sites of inoculation of vaccinia virus, animals not treated with interferon developed typical pustulous reactions and then smaller secondary lesions. human leukocyte interferon (5 x 10(5) international units per day) injected intramuscularly, either from one day before to three days after infection or for seven days beginning on the first day of primary reaction ...	1976	180202
prophylactic control of simian hemorrhagic fever in monkeys by an interferon inducer, polyriboinosinic-polyribocytidylic acid-poly-l-lysine.	a nuclease-resistant complex of polyriboinosinic-polyribocytidylic acid containing poly-l-lysine and carboxymethylcellulose was used as prophylactic treatment of simian hemorrhagic fever in rhesus monkeys. this infection has proven uniformly fatal to more than 50 monkeys. treatment 8 hr before infection and repeatedly thereafter completely prevented the development of viremia and death. untreated animals died before development of antibodies to the virus. none of the treated animals developed an ...	1976	180207
complete regression of a guinea pig hepatocarcinoma by immunotherapy with "tumor-immune" rna or antibody to fibrin fragment e.	two novel immunotherapeutic regimens were developed for a uniformly lethal, intradermally growing transplantable ascites variant (line 10) of a diethylnitrosamine-induced hepatoma in strain 2 guinea pigs. in an apparently tumor-specific immunotherapy model, 32 guinea pigs were cured by the injection into the tumor area, five or seven days after tumor challenge, of syngeneic or xenogeneic rna extracts obtained from lymphoid tissues of line 10-immune strain 2 guinea pigs or rhesus monkeys, as part ...	1976	181352
pathology of chronic bolivian hemorrhagic fever in the rhesus monkey.	gross and microscopic lesions of bolivian hemorrhagic fever (bhf) are described in 10 rhesus monkeys that survived from 30 to 78 days after subcutaneous inoculation with a dose of 10(3) plaque-forming units (pfu) of machupo virus, a dose which produces a severe and generally fatal disease. six of the monkeys had been given low doses of homologous immune globulin when initial signs of infection appeared. monkeys exhibited clinical signs in two phases. the initial signs of acute infection which be ...	1976	181994
infection of wild and laboratory animals with machupo and latino viruses.	natural infection with machupo and latino viruses occurs only in the cricetine rodent calomys callosus. machupo virus induces fatal infection in suckling mice and hamsters, and in adult guinea-pigs, marmosets, and rhesus monkeys. latino virus kills only suckling hamsters; it produces chronic but non-viraemic infection in calomys rodents.machupo virus, in contrast, induces a viraemic immunotolerant infection in suckling calomys, and a split response in animals more than 9 days of age. tolerant in ...	1975	182399
status of arenavirus vaccines and their application.	a limited but definite need exists for vaccines against lassa, junin, and machupo viruses. medical and laboratory personnel, as well as defined high-risk population groups, require protection from these highly virulent agents. to date little work has been done on inactivated vaccines for these viruses. a live attenuated junin vaccine has been tested successfully in more than 600 persons, and a high-passage machupo virus strain has protected rhesus monkeys against lethal infection produced by a h ...	1975	182407
effect of indomethacin on cyclic amp phosphodiesterase activity in myometrium from pregnant rhesus monkeys.	our results indicate that indomethacin inhibits cyclic amp phosphodiesterase in the myometrium of the pregnant rhesus monkey under in vitro as well as in vivo conditions. kinetic data on extracts of myometrium from pregnant rhesus monkeys indicated two cyclic amp phosphodiesterase activities. the apparent km value for the high affinity enzyme averaged 3.9 mum and for the low affinity enzyme 23 mum; the vmax values averaged 0.56 and 1.4 nmoles cyclic amp hydrolized per mg protein min-1 respective ...	1976	183237
comparative epidemiological aspects of naturally occurring malignant lymphoma in domestic cats and rhesus monkeys.		1975	183676
a new serum lipoprotein found in many rhesus monkeys.		1976	183769
cardiovascular and neuromuscular effects of dimethyl tubocurarine in anaesthetized cats and rhesus monkeys.	intravenous dose-response relationships for dimethyl tubocurarine showed that vagal blockade only became appreciable (50-83%) at doses 8-16 times those sufficient for full neuromuscular paralysis in anaesthetized cats (0.0625 mg/kg) and rhesus monkeys (0.125 mg/kg); heart rate was unchanged. sympathetic function was unimpaired by supramaximal paralysing doses of 0.5 and 1 mg/kg in cats, but was reduced (20-41%) by comparable neuromuscular paralysing doses of 1 and 2 mg/kg in rhesus monkeys; thes ...	1976	183800
rhesus monkeys kidney cells persistently infected with simian virus 40: production of defective interfering virus and acquisition of the transformed phenotype.	monolayer cultures of llc-mk2 rhesus monkey kidney cells became persistently infected with simian virus 40 (sv40) when infected at a multiplicity of infection of 100 plaque-forming units/cell. a stable carrier state developed characterized by extensive viral proliferation without obvious cytopathic effect other than the slow growth of these cultures. by 11 weeks all cells produced the sv40 t antigen. in contrast, less than 5% of the cells produced v antigen. virus-free clonal isolates were obtai ...	1976	184052
replication of murine paramyxoviruses in hamster tracheal organ culture and comparison with standard tissue culture methods.	replication of sendai virus, pneumonia virus of mice, and sv5 was investigated in tracheal organ cultures from 2- to 4-day-old and 2- and 4-week-old hamsters, and viral infectivity in tracheal explants was compared with that in tissue culture monolayers. explants from 2- to 4-day-old hamsters produced higher titers of the three paramyxoviruses, as detected by hemadsorption with guinea pig and murine erythrocytes in primary rhesus monkey kidney cells. tracheal cultures from 2- and 4-week-old hams ...	1976	184110
stimulation of proliferation in stationary primary cultures of monkey aortic smooth muscle cells. part 2. effect of varying concentrations of hyperlipemic serum and low density lipoproteins of varying dietary fat origins.	the outgrowth of medial explants of thoracic aorta from rhesus monkeys has used to study the influence of hyperlipemic serum on cell proliferation. after 5-6 weeks of rapid growth in bme plus 10% normal serum, the cultures reach a stationary phase during which they show little mitotic activity. when it replaces 5% of the normal serum in the media, hyperlipemic serum induces another proliferative phase in the cultures, as measured by [3h1thymidine incorporation and increase in culture area. low d ...	1976	184801
potentiation of the acth response to metyrapone by l-dopa in the monkey.	the intravenous injection of l-dopa (15 mg/kg) to monkeys (macaca mulatta) failed to alter plasma concentrations of acth and of 11-deoxy-cortisol. when cortisol synthesis was blocked with iv metyrapone, potentiation of acth secretion by l-dopa became apparent. simultaneous injection of l-dopa and metyrapone resulted in a marked increase in plasma acth from 93 +/- 18 pg/ml to 432 +/- 80 pg/ml, whereas plasma 11-deoxycortisol increased from 1.5 +/- 0.2 mug/100 ml to 14.6 +/- 1.0 mug/100 ml 90 min ...	1976	185048
neurovirulence testing of oral poliovaccine in the rhesus monkey.		1976	186408
serum lipid and lipoprotein responses of six nonhuman primate species to dietary changes in cholesterol levels.	the response of serum lipids and lipoproteins to different levels of cholesterol in the diet was studied in chimpanzee (pan troglodytes), rhesus (macaca mulatta), green (cercopithecus aethiops), patas (erythrocebus patas), squirrel (saimiri sciurea) and spider (ateles sp.) monkeys. five animals of each species were fed increasing amounts of dietary cholesterol (0.05% to 1.5% w/w) for 3-week periods; between each experimental diet, the animals were fed a basal diet without cholesterol for a simil ...	1976	186573
dynamics of adenosine-3', 5'- monophosphate transfer among mother, fetus, and amniotic fluid in the rhesus monkey.	cyclic amp exchange among the mother, amniotic fluid, and fetus was studied in normal rhesus monkeys at term pregnancy. following a pulse intravenous administration of 3h-cyclic amp into the mother, a small fraction of the dose appeared in less than 1 minute in fetal blood. it appeared in the amniotic fluid after 5 minutes and reached maximum level in 20 minutes. the accumulation of 3h-cyclic amp in the amniotic fluid in 1 hour was 0.03 per cent of the injected dose. the amount and time course o ...	1976	187058
the effect of cholesterol feeding on primate serum lipoproteins. i. low density lipoprotein characterization from rhesus monkeys with high serum cholesterol.		1976	187177
effect of adrenergic blockade and dexamethasone on the aldosterone response to brain stimulation in the rhesus monkey.	the increase in aldosterone and plasma renin activity (pra) observed after stimulation of extrahypothalamic sites within the brain of the rhesus monkey was prevented by the prior administration of the beta-adrenergic blocking agent propranolol. alpha-adrenergic blockade by phentolamine had no inhibiting effect. propranolol only partially reduced the response of aldosterone to lateral hypothalamic stimulation in spite of inhibition of pra; a partial reduction in aldosterone was also obtained from ...	1976	187707
sequential hepatic histologic and histochemical changes produced by diethylnitrosamine in the rhesus monkey.	six young adult male rhesus monkeys were given diethylnitrosamine ip for 3-5 years. liver biospies were done monthly. after 6 months, biopsy specimens showed individual hepatocytes and small foci of hepatocytes that were intensely positive for glycogen. during the second and later years, larger foci of such cells developed. in sections stained with hematoxylin and eosin, the glycogen-containing hepatocytes generally appeared unusually clear. some hepatocytes, however, had eosinophilic or basophi ...	1976	187798
hyperreactive arterial endothelial cells: a clue for the treatment of atherosclerosis.	arterial endothelial cells, which are capable of phagocytizing carbon particles of the same size as beta- and pre-beta-lipoprotein, were found only in endothelial cells of arterial segments susceptible to atheromatous changes in susceptible animal species, and the distribution closely corresponded to the susceptibility. the distribution of such endothelial cells is dense in large arteries, in the openings to their branches, especially in downstream portions, of rabbits, hens, and cocks; however, ...	1976	188368
comparison of the serum low density lipoprotein and of its apoprotein in the pig, rhesus monkey and baboon with that in man.	the principal form of the serum low density lipoprotein (ldl) in man, baboon, rhesus monkey and pig was isolated by preparative ultracentrifugation in the density interval 1.024-1.045 g/ml. the physicochemical characteristics of pig ldl most closely resembled those of man; thus, electrophoretic studies suggested that both baboon and rhesus ldl have a greater surface charge than that of their human counterpart, and electron-microscopic investigations showed baboon ldl (245 a) to be larger and rhe ...	1976	188432
study of abnormal plasma low-density lipoprotein in rhesus monkeys with diet-induced hyperlipidemia.	male rhesus monkeys were divided into three groups: five were fed a regular primate chow diet and were used as controls; four received an "average" american diet; and five a special low-fat primate chow diet supplemented with 25% coconut oil and 2% cholesterol. in all of these animals, the plasma low-density lipoproteins (ldl) were isolated by ultracentrifugal flotation between densities of 1.019 and 1.050 g/ml. the ldl of the five control monkeys had variable molecular weights, with a mean valu ...	1976	188443
influence of lysophosphatidylcholine on the metabolism of plasma lipoproteins.	both low density lipoproteins and cellular membranes are known to have a high affinity for lysophosphatidylcholine. in this study lysophosphatidylcholine influenced the retention of lipoproteins by arterial tissue in vitro and the rate of disappearance of low density lipoproteins from the blood in vivo. pieces of aorta from rabbits or rhesus monkeys were successively incubated for 90 min each in 2 or 3 solutions. after the last incubation the intima plus inner media was dissected from the remain ...	1976	188451
plaque assay of neonatal calf diarrhea virus and the neutralizing antibody in human sera.	neonatal calf diarrhea virus (a bovine rotavirus) formed distinct plaques in monolayers of ma-104 cells, an established macacus rhesus monkey kidney cell line, when diethylaminoethyl dextran and trypsin were included in the overlay medium. by using this plaque assay method, titration of neutralizing antibody to neonatal calf diarrhea virus was made feasible. it was demonstrated that some human sera contained neutralizing antibody to this agent.	1977	188863
cortisol secretion and clearance in the rhesus monkey.	cortisol secretory patterns were studied in two chair-adapted rhesus monkeys by simultaneous measurement of plasma concentration and specific activity of cortisol after an iv bolus of 14c-labeled hormone. the results indicated that fluctuating plasma cortisol concentrations are the result of episodic secretion by the adrenal cortex. specific activity changes during these spontaneous secretory bursts indicated occasional submaximal activity. in addition, cortisol secretory rates calculated during ...	1977	189992
estrogen metabolism in nonhuman primates. i. in vitro biosynthesis of estrogen glucosiduronates in rhesus monkey liver.	estrone glucosiduronate, 17beta-estradiol-3-glucosiduronate, 17beta-estradiol-17-glucosiduronate and estriol-16alpha-glucosiduronate have been biosynthesized in substantial yield by incubation of radioactive estrone, 17beta-estradiol, estriol and uridine diphosphoglucosiduronic acid with rhesus monkey liver homogenates. the metabolites were characterized by chromatography on celite and deae-sephadex, enzyme hydrolysis, derivative formation and crystallization to constant specific activity. the p ...	1977	190739
[ultrastructural changes in the central nervous system of monkeys in poliomyelitis].	the ultrastructure of cells of the central nervous system of rhesus monkeys in experimental poliomyelitis caused by virus of poliomyelitis type 3 was studied. it was found out that the virus of poliomyelitis was localized in nerve cells, astocytes, oligodendrocytes, the endothelium of capillaries and macrophages. this justifies the conclusion that pathological changes in the cells referred to the above result from reproduction of the virus therein. ultrastructural changes in infected cells are d ...	1976	190980
stimulation of cholesterol esterification in rhesus monkey arterial smooth muscle cells.	the influence of homologous high density lipoprotein (hdl) and low density lipoprotein (ldl) and of whole hypercholesterolemic serum on the esterification of oleic acid and cholesterol was studied in rhesus monkey arterial smooth muscle cells. whole hypercholesterolemic serum and isolated ldl stimulated cholesterol esterification as much as 10-fold using either cholesterol-1,2-3h or oleate-1-14c as substrate. at the same concentrations of cholesterol, hdl stimulated cholesterol esterification to ...	1977	191212
characterization of plasma low density lipoproteins on nonhuman primates fed dietary cholesterol.	ldl from animals of three nonhuman primate species, macaca mulatta, macaca fascicularis, and cercopithecus aethiops, were studied. a standard preparation of 125i-ldl was added to isolated lipoprotein mixtures just prior to separation of plasma lipoproteins by agarose gel chromatography. a relative size index, ri, was determined by dividing the elution volume of the iodinated ldl by the elution volume of the sample ldl, both volumes being determined simultaneously during chromatographic elution. ...	1997	191551
comparative complement fixation and serum neutralization antibody titers to herpes simplex virus type 1 and herpesvirus simiae in macaca mulatta and humans.	the serological relationship of herpes simplex type 1 virus and herpesvirus simiae was studied. antibody titers to these viruses were determined in 163 macaca mulatta sera and 67 human sera by serum neutralization (sn) and complement fixation (cf) tests. both groups of sera were also tested by cf with envelope and capsid antigens of herpes simplex type 1. by sn, the majority of the monkeys and all of the humans had a higher titer to herpes simplex type 1 than to h. simiae. by cf, with crude anti ...	1977	192762
spontaneous malignant histiocytoma with metastasis in a rhesus monkey [macaca mulatta].	a malignant histiocytoma was observed on the left arm of a recently imported rhesus monkey. rapid invasion of deep tissues and tumor growth on the face prompted euthanasia. necropsy revealed additional neoplastic foci in the lungs, diaphragm, intercostal muscles, pericardium and liver. microscopically the predominant cell type was histiocytic; some cells had a distinct epithelioid appearance and other were spindle-shaped.	1977	194039
effects of cholesterol feeding on primate serum lipoproteins. ii. low density lipoprotein characterization from rhesus monkeys with a moderate rise in serum cholesterol.		1977	194586
dengue viruses and mononuclear phagocytes. ii. identity of blood and tissue leukocytes supporting in vitro infection.	studies were made on the identity of human and monkey mononuclear leukocytes permissive to antibody-enhanced dengue 2 virus (d2v) infection. in cultures of peripheral blood leukocytes (pbl) inoculated immediately after separation, it was concluded that only mononuclear phagocytes support dengue infection. this is based upon observations that d2v-permissive cells were resistant to 1,200 rads, were both plastic adherent and nonadherent, were removed when passed through nylon wool columns in 10 per ...	1977	195000
comparison of primary rhesus and cynomolgus monkey kidney cell cultures for viral isolation from clinical specimens.	rhesus monkey kidney and cynomolgus monkey kidney cell cultures were compared for viral isolation by using clinical specimens that yielded 203 viral isolates. cynomolgus and rhesus monkey kidney cells were comparable for the isolation of 22 adenoviruses, 12 coxsackieviruses, and one poliovirus. four of 50 echoviruses and seven of ten herpesviruses were detected only in cynomolgus monkey kidney cells. influenza virus was isolated in 84 instances, of which eight were detected only in rhesus and fo ...	1977	195459
in vitro regulation of cholesterol metabolism by low density lipoproteins in skin fibroblasts from hypo-and hyperresponding squirrel monkeys.	when squirrel monkeys (saimiri sciureus) are fed diets containing cholesterol, some individuals (hyperresponders) become hypercholesterolemic, while others (hyporesponders) are able to maintain nearly normal plasma cholesterol concentrations. skin fibroblasts were grown from three hyperresponder and threehyporesponder squirrel monkeys, previously characterized on the basis of their plasma cholesterol response to two cholesterol-containing diets and the pheno-type of their parents. the rates of c ...	1977	195626
maintenance of viability and comparison of identification methods for influenza and other respiratory viruses of humans.	a comparison of hanks balanced salt solution, veal infusion broth (vib), and charcoal viral transport medium for maintaining viability of type a influenza virus indicated approximately equal survival of virus on all three media at -70 and 4 degrees c, whereas at 25 degrees c virus survived best in vib. vib supplemented with bovine serum albumin was used as transport medium in a community-wide surveillance of febrile respiratory disease for influenza viruses. unfrozen throat swab specimens were p ...	1977	195979
preparation and evaluation of a noninfectious monkey pox virus vaccine.	monkey pox virus was mechanically disrupted by low temperature and high pressure into soluble and insoluble fractions. soluble fractions elicited virus-neutralizing antibodies (1:20 to 1:160) in rabbits, whereas the insoluble (in saline) fractions did not (less than 1:5). no infectious virus was detected after the disruption procedure. rhesus monkeys immunized with the soluble fraction elicited virus-neutralizing (1:1,200), complement-fixing (1:16), and hemagglutinating-inhibiting (1:80 to 1:160 ...	1977	195980
effects of prostaglandins on cultured granulosa cells from rhesus monkeys.		1977	196077
[detoxification of staphylococcal-enterotoxin b in water (author's transl)].	staphylococcal enterotoxin b contaminated water has been detoxified with calcium hypochlorite used in the water treatment procedure which is available now in order to get drinking water from surface water in emergency cases. changes in toxin-activity were measured serologically by agar-gel-immuno-precipitation as well as biologically by the "monkey-feeding test" with young macaca mulatta. with an initial concentration of 50 ppm chlorine in tap water resp. 200 ppm in native surface water concentr ...	1977	196459
the self-association of apolipoprotein a-ii from plasma high density lipoproteins of rhesus monkey (macaca mulatta).		1977	197103
evidence for dopamine-storing interneurons and paraneurons in rhesus monkey sympathetic ganglia.	in order to study and quantify the small, intensely fluorescent (sif) cells and to examine their synaptology, the superior cervical sympathetic ganglia of rhesus monkeys were examined by a sequential glyoxylic acid (ga) monoamine fluorescence and electron microscopic technique. correlated data concerning the sensitivity of the ganglia to dopamine were gathered by measuring the rise in cyclic amp levels following incubation in vitro with exogenous dopamine. cyclic amp levels after incubation for ...	1977	197214
isolation of simian virus 40 from rhesus monkeys (macaca mulatta) with spontaneous progressive multifocal leukoencephalopathy.	isolates of virus from the brain tissue of two naturally occurring cases of progressive multifocal leukoencephalopathy in rhesus monkeys (macaca mulatta) have been characterized. both isolates were demonstrated to be simian virus 40 (sv40) by serological tests and analysis of cleavage fragments of viral deoxyribonucleic acid produced by restriction endonuclease from haemophilus influenzae. sv40 virions and the nonvirion t antigen were demonstrated in the brain lesions of one monkey by the fluore ...	1977	198489
experimental carcinoma of liver in macaque monkeys exposed to diethylnitrosamine and hepatitis b virus.	the effects of treatments with diethylnitrosamine (dena) and hepatitis b virus (hbv) on macaque monkeys were investigated by virus serology and by light and electron microscopy. the experimental groups comprised 43 newborn or juvenile cynomolgus and rhesus monkeys of both sexes. hbv neither had a carcinogenic effect nor increased the oncogenic effect of dena. however, hbv given to juvenile primates before treatment with dena resulted in subsequent gross and microscopic alterations consistent wit ...	1977	198564
the behaviour of sabin attenuated poliovirus strains in the central nervous system of rhesus monkeys.		1977	200628
sedimentation behavior of native and reduced apolipoprotein a-ii from human high density lipoproteins.	the solution properties of human serum apolipoprotein a-ii, both in the native and in the reduced forms, were investigated by the technique of sedimentation equilibrium in the analytical ultracentrifuge. for both proteins, the apparent weight average molecular weights determined in neutral buffer systems were found to be dependent on protein concentration and invariant with the rotor speeds used (16,000 to 44,000 rpm) indicating a reversible self-association. these results were also found to be ...	1978	201282
effect of input multiplicity on the establishment of simian virus 40 persistent infections in rhesus monkey kidney cells.	monolayer cultures of llc-mk2 rhesus monkey kidney cells become persistently infected with simian virus 40 after infection at input multiplicities of 100, 10, or 1 plaque-forming unit per cell. after 3 weeks, all cells of the cultures infected at a multiplicity of 1 plaque-forming unit per cell produced the simian virus 40 t antigen. in contrast, 8 to 11 weeks elapsed before all the cells in the cultures infected at a multiplicity of 100 plaque-forming units per cell produced t antigen. defectiv ...	1977	201570
nonhuman primates: laboratory animals of choice for neurophysiologic studies of sleep.	a systematic study was made of several nonhuman primates to learn more about their relative usefulness for studies of sleep. species studied included the guinea baboon (papio papio), kenya or yellow baboon (p cynocephalus), olive baboon (p anubis), sacred baboon (p hamadryas), vervet monkey (cercopithecus aethiops), rhesus monkey (macaca mulatta), bonnet monkey (m radiata), crab-eating monkey (m fascicularis), patas monkey (erythrocebus patas), chimpanzee (pan troglodytes), mongoose lemur (lemur ...	1977	201798
interspecies radioimmunoassay for the major structural proteins of primate type-d retroviruses.	a competition radioimmunoassay has been developed in which type-d retroviruses from three primate species compete. the assay utilizes the major structural protein (36,000 daltons) of the endogenous squirrel monkey retrovirus and antisera directed against the major structural protein (27,000 daltons) of the mason-pfizer monkey virus isolated from rhesus monkeys. purified preparations of both viruses grown in heterologous cells, as well as extracts of heterologous cells infected with squirrel monk ...	1977	202962
[sleep changes induced by chronic administration of s. 1694 (survector) (author's transl)].	five adult macaca mulatta were studied during chronic administration (24 days) of s. 1694 (10 mg/kg, i.m.). this substance induced a significant increase of the first awakening (delaying sleep onset) and an enhancement of the duration of rem and stage 4 sleep. after withdrawal, the waking effect desappeared, but the increase in stage 4 sleep was maintained for one week and rem enhancement kept rising for 15 days. this observation of long-term action underlined the validity of drug experiments in ...	1989	202987
histochemical distribution of phosphatases in different regions of the epididymis of the adult rhesus monkey macaca mulatta.		1977	203524
phytohemagglutinin enhancement of dengue-2 virus replication in nonimmune rhesus monkey peripheral blood leukocytes.	phytohemagglutinin treatment of peripheral blood leukocytes from dengue nonimmune monkeys enhanced dengue-2 virus replication. enhancement was due primarily to an increase in the number of infected cells. destruction of mononuclear phagocytes with silica did not significantly inhibit virus replication in phytohemagglutinin-treated cultures. pokeweed mitogen, concanavalin a, and streptolysin o stimulated increased deoxyribonucleic acid synthesis in monkey leukocytes but did not enhance virus repl ...	1978	203535
cerebrospinal fluid cyclic amp levels in rhesus monkeys: daily fluctuations.		1978	203813
morphine reduces cerebellar guanosine-3',5'-cyclic monophosphate content and elevates cerebrospinal fluid guanosine-3',5'-cyclic monophosphate content in rhesus monkey.		1978	203814
measurment of rhesus monkey (macaca mulatta) apolipoprotein b in serum by radioimmunoassay: comparison of immunoreactivities of rhesus and human low density lipoproteins.	a sensitive and specific double antibody radio-immunoassay for the major apolipoprotein (apob) of rhesus (macaca mulatta) serum very low density lipoprotein (vldl) and low density lipoprotein (ldl) is described. the anti-serum was raised to ldl (d 1.030-1.040 g/ml) and the ldl(2) (d 1.020-1.050 g/ml) was labeled with (125)i by the chloramine-t or iodine monochloride method. the assay, which was sensitive to 0.02-0.5 micro g of ldl(2), had an inter-assay coefficient of variation of 4.5%. this ass ...	1978	204718
necrotizing pancreatitis due to simian adenovirus type 31 in a rhesus monkey.	simian adenovirus type 31 was isolated from pancreatic tissue of an 8-year-old male rhesus monkey that died as the result of acute necrotizing pancreatitis. histologically, the pancreas showed wide-spread necrosis, extensive infiltration of polymorphonuclear leukocytes, and nuclear inclusions in pancreatic acinar cells. large numbers of adenovirus particles were demonstrable in the acinar cells by electron microscopy. this is the second case of adenovirus-associated pancreatitis we have found in ...	1978	205187
endocrine and pharmacological factors which influence the onset of labour in rhesus monkeys.	indomethacin administration in late pregnancy prolonged gestation in caged rhesus monkeys and inhibited premature labour and postponed delivery in chronically catheterized monkey fetuses. chronic indomethacin treatment was associated with a reduction in the urinary excretion of a prostaglandin metabolite, a potent inhibitory effect on myometrial cyclic amp phosphodiesterase, and severe oligohydramnios in pre-term and post-term fetuses. experimental anencephaly (functional hypophysectomy) of the ...	1977	205394
effect of cardiac arrest on cerebral circulation. an experimental investigation.	the effect of 2 to 15 min of cardiac arrest on cerebral circulation was investigated in dogs and rhesus monkeys. when circulatory arrest lasted longer than 5 minutes, angiographic changes of the no-reflow phenomenon were observed between 3 and 4 h after resuscitation in dogs but not in monkeys. these findings were (1) marked prolongation of the arterial phase in both intracranial and extracranial arteries; followed by (2) occasional evidence of dilatation of the proximal intracranial arteries wi ...	1976	207089
[use of the monkey pox virus for evaluating the intensity of the immunity against smallpox in experiments on m. rhesus].	monkeypox virus causing in m, rhesus upon aerogenic infection a disease similar to human varioloid was used to evaluate the intensity of immunity against smallpox in immunized m. rhesus monkeys. postvaccination immunity was solid in all the animals vaccinated intradermally or orally. in 2 out of 14 monkeys immunized orally, however, the immunity was partially overcome. neutralizing antibody titers in these two monkeys were 1:5 and 1:25, respectively. this agreed with the observations made in pak ...	1978	208308
differential effects of isolated lipoproteins from normal and hypercholesterolemic rhesus monkeys on cholesterol esterification and accumulation in arterial smooth muscle cells in culture.	whole serum obtained from hypercholesterolemic rhesus monkeys was found to stimulate cholesterol esterification and cholesteryl ester accumulation in rhesus monkey arterial smooth muscle cells in culture to a significantly greater extent than normocholesterolemic serum. this was true even when the cholesterol concentration of the culture medium was equalized. isolation and characterzation of the low density lipoproteins (ldl) from rhesus monkeys indicated that the ldl from hypercholesterolemic a ...	1978	208631
the refractory state of luteal cells isolated from rhesus monkeys after prolonged exposure to chorionic gonadotropin during early pregnancy.		1978	208669
loss on serial passage of rhesus monkey kidney cells of proteolytic activity required for sendai virus activation.	primary and secondary cultures of rhesus monkey kidney cells supported multiple-cycle replication of sendai virus, but later passages lost this ability, and this was reflected in decreased plaque formation. multiple-cycle replication also did not occur in llc-mk2 cells, a continuous line of rmk cells. failure of replication in serially passed cells was correlated with a decrease in proteolytic cleavage of a viral surface glycoprotein (fo), and the ability of cells to support multiple-cycle repli ...	1978	208971
responses of nonhuman primates to a polybrominated biphenyl mixture.	in a series of experiments, rhesus monkeys have been given in their diets 0.3, 1.5, and 25 ppm of a commercial polybrominated biphenyl (pbb) (as firemaster ff-1). the seven adult female monkeys receiving 0.3 ppm pbb have been on the treatment regime for 15 months and have consumed over 22 mg of pbb. during the initial 6 months of exposure, they lost weight and 2 of the animals develop sterile abscesses. at 6 months, 4 of the 7 animals had flattened and lengthened serum progesterone peaks. this c ...	1978	209967
opiate receptor binding in rhesus monkey brain: association with limbic structures.		1978	210898
spontaneous esophageal carcinoma and epithelial cell line of an adult rhesus monkey.	a continuous epithelial cell line, 816a, was established from a lymph node of an adult rhesus monkey with metastatic esophageal carcinoma. these cells are characterized by the presence of desmosomes and a markedly heteroploid karyotype. at a relatively early culture age, electron microscopy showed both budding and extracellular type c virus. antigen reactive with antisera to mason-pfizer monkey virus was observed by complement-fixation. the level of this antigen decreased with increased culture ...	1978	210934
caffeine elicited withdrawal signs in morphine-dependent rhesus monkeys.	in the dose range of 4.0--32.0 mg/kg s.c., caffeine produced most of the signs which are commonly seen after the administration of naloxone (0.05 mg/kg s.c.) to morphine-dependent monkeys. the signs designated as lying on side or abdomen, avoiding contact, vocalizing, crawling or rolling, restlessness or pacing, tremors, retching, vomiting, coughing, vocalizing when abdomen palpated, rigid abdomen and salivation were noted. a randomized and blind experimental design, which included vehicle and p ...	1978	211041
disseminated lymphoma in a rhesus monkey: a case report.	a rhesus monkey was inoculated with rhesus cytomegalovirus. a leukocyte-associated herpes virus, unrelated to cytomegalovirus, was later isolated from the same monkey. four years after the virus inoculation, the monkey developed a disseminated lymphoma.	1978	212640
the effects of prolonged ingestion of dieldrin on the livers of male rhesus monkeys.		1978	214292
the acth 'family tree' of the rhesus monkey changes with development.		1978	214709
comparative sensitivity of various cell culture systems for isolation of viruses from wastewater and fecal samples.	in efforts to define the most sensitive cell culture systems for recovery of viruses from wastewaters, 181 samples were inoculated in parallel into tube cultures of various cell types and were plaqued in bottle and petri dish cultures of three types of monkey kidney cells. polioviruses were recovered most frequently in the rd line of human rhabdomyosarcoma cells, group a coxsackieviruses in rd and human fetal diploid kidney (hfdk) cells, group b coxsackieviruses in the bgm line of african green ...	1978	215087
effect of corticotrophin on cortisol secretion in castrated rhesus monkeys.		1978	215692
effects of local anesthesia on gingival camp levels.	the basal levels of camp in the attached gingiva of rhesus monkeys and the changes in tissue camp levels produced by infiltration anesthesia with lidocaine and lidocaine containing 1:100,000 epinephrine were studied. the basal level of camp in uninjected monkey gingiva ranged from 12 to 20 picomoles of camp per mg of gingival protein. this level was 75 times greater than the camp content of monkey blood plasma. infiltration of the attached gingiva with saline or plain lidocaine for 5 minutes did ...	1979	216792
in vivo regulation of the fetal rhesus monkey adrenal gland.		1978	217644
viral antibodies in rhesus monkey sera collected in india.		1978	217821
development and experimental evaluation of a contrast medium for computed tomographic examination of the liver and spleen.	a lipoid based contrast material containing 53% of ethiodized oil in emulsion form was developed for computed tomography (ct) of the liver and spleen and tested in rabbits and monkeys. an intravenous dose of 0.2 ml/kg selectively opacified the liver and spleen, resulting in an average increase of 23 emi units (500 scales) in the attenuation of the liver and a higher increase in the attenuation of the spleen. when injected into rhesus monkeys with carcinogen induced hepatomas there was a signific ...	1979	217896
protease activation of sendai virus infectivity; studies in non-permissive and permissive cells.	non-infectious virus particles are produced by bsc-1 cells after infection with sendai virus. trypsin treatment of these particles activates their infectivity. the studies reported here show that such non-infectious virus particles adsorb normally to cells but cannot initiate infection even after very long adsorption periods. secondary rhesus monkey kidney cells support the growth of sendai virus but cannot activate the infectivity of virus grown in bsc-1 cells. the significance of these results ...	1978	217954
viral type a and type b hepatitis: morphology, biology, immunology and epidemiology--a review.	viral hepatitis is one of the most serious infectious diseases in the united states and is of great concern to the public health agencies, hospitals and research laboratories. progress in our knowledge of this disease has been based on cooperation between specialists in many diverse scientific disciplines employing sophisticated scientific instruments and technics. close cooperation between clinical pathologists and clinicians is of great importance in diagnosis. biologic, immunologic, epidemiol ...	1976	218439
virus particles in the basal plate of rhesus monkey and baboon placenta.	c-type virus particles and particles, approximately 35 nm in diameter, were present in the region of the basal plate from the placenta of a rhesus monkey and two baboons. both particles appeared to bud from the plasma membrane of the cytotrophoblast: large, pleomorphic cells with cytoplasmic extensions, indented nuclei, well-developed endoplasmic reticulum, and glycogen deposits. extracellular particles were enmeshed within a fibrous matrix. particles were also observed in the junctional zone, b ...	1979	218734
canine kidney cell line for isolation of respiratory viruses.	by means of a continuous canine kidney cell line (mdck), influenza viruses were rapidly isolated from specimens collected from patients with respiratory disease. the cell line proved more sensitive than either eggs or rhesus monkey cells for currently circulating influenza a and b strains. influenza viruses caused a distinct cytopathology within 5 days of inoculation if trypsin-ethylenediamine-tetraacetic acid was incorporated into the medium. sufficient hemagglutinin was produced on the initial ...	1979	219021
pyruvate carboxylase deficiency and lactic acidosis in a retarded child without leigh's disease.	a child with lactic acidosis, severe mental and developmental retardation, and proximal renal tubular acidosis is presented. biopsy and autopsy studies show severe hepatic, renal cortical, and cerebral deficiencies in pyruvate carboxylase (ec 6.4.1.1) activity. the patient had 1.81 +/- 0.20 units/g fresh weight at biopsy and 0.75 +/- 0.07 units/g fresh weight hepatic pyruvate carboxylase activity at autopsy compared with 10.9, 11.3, and 9.5 units/g fresh weight in two autopsy and one biopsy cont ...	1979	219411
isolation and biological characterization of an adenovirus of rhesus macaques.	the etiology of a disease in rhesus monkeys the main clinical manifestation of which was acute conjunctivitis of an epizootic character has been studied. the cytopathogenic agent well propagating in primarily trypsinized kidney cells of monkeys has been isolated when investigating the affected eye mucosa. it was not pathogenic for laboratory animals. the mean diameter of the virions is 75 nm, the buoyant density in cscl is 1.34 g/cm3, the viral dna density is 1.706 g/cm3. the biological properti ...	1978	219642
the effect of coffee consumption on plasma lipids, lipoproteins, and the development of aortic atherosclerosis in rhesus monkeys fed an atherogenic diet.	rhesus monkeys (seven females and six males) were fed ad libitum a diet comparable to that consumed by humans, containing 25% by weight fat (40% of calories) and 0.15% cholesterol (0.3 mg/kcal) for 12 months (phase 1). from the 13th month all monkeys were continued on the diet while four females and three males were given 50% coffee as their fluid intake and the remainder were water controls (phase 2). major changes in total plasma lipids and lipoprotein profiles occurred within 3 months and gen ...	1979	219678
effect of acute administration of dichlorodiphenyl trichloroethane on certain enzymes of rhesus monkey.		1978	220189
study of the atherogenic dyslipoproteinemia induced by dietary cholesterol in rhesus monekys (macaca mulatta).	hypercholesterolemia was induced in adult male rhesus monkeys with a high-fat diet containing an elevated cholesterol level (0.5%). plasma lipoproteins were chromatographically separated into four size populations (regions) that were subdivided by density until fractions with single electrophoretic mobilities were obtained. the region iii lipoproteins (ldl) contained 80% of plasma cholesterol and were present in the highest concentration of all fractions. their molecular weight was increased ove ...	1979	220353
regulation of cyclic nucleotide phosphodiesterase activity in myometrium from pregnant and spayed rhesus monkeys.	the activities of myometrial cyclic nucleotide phosphodiesterases (pdes) and the sensitivity of these enzymes to the effector molecules, cgmp and camp, were determined in the 100,000 g supernatant of homogenates from pregnant and spayed rhesus monkeys. the specific activities (per mg nitrogen) of the myometrial cyclic nucleotide pdes in the supernatant from spayed monkeys were higher than those from pregnant monkeys at all substrate levels studied. however, when calculated on the basis of the dn ...	1979	220417
isolation of a cytomegalovirus from salivary glands of white-lipped marmosets (saguinus fuscicollis).	minced salivary glands from seven white-lipped marmosets (saguinus fuscicollis and saguinus nigricollis) and one cotton-topped marmoset (saguinus oedipus) were cocultivated with marmoset cell cultures. a viral agent, designated ssg, was isolated from two saguinus fuscicollis. slowly progressing foci of rounded, vacuolated, refractile cells were first observed at 40-43 days incubation. electron microscopy revealed intranuclear herpesvirus nucleocapsids and intracytoplasmic and extracellular envel ...	1979	220464
in utero regulation of rhesus monkey fetal adrenals: effects of dexamethasone, adrenocorticotropin, thyrotropin-releasing hormone, prolactin, human chorionic gonadotropin, and alpha-melanocyte-stimulating hormone on fetal and maternal plasma steroids.		1979	221193
in vitro lymphocyte transformation by epstein-barr virus (ebv)-like viruses isolated from old-world non-human primates.	ebv-like viruses and lymphoid cell lines have been isolated from baboons and an orangutan. the cell lines have properties of b- or undifferentiated lymphocytes and have antigens and dna related to those of ebv. the baboon virus has a broad in vitro transformation host range among lymphocytes of old-world simian species whereas the orangutan isolate has a narrower host range. baboon and orangutan viruses as well as ebv have shown transforming activity for gibbon lymphocytes. baboon virus is infec ...	1978	221359