Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| a pilot study on the effects of aroclor 1254 ingestion by rhesus and cynomolgus monkeys as a model for human ingestion of pcbs. | a pilot study using female cynomolgus (macaca fascicularis) and female rhesus (macaca mulatta) monkeys was conducted to study the effects of chronic ingestion of polychlorinated biphenyls (pcbs). four control and four treated monkeys of each species received an apple juice-gelatin mixture containing 0 and 280 micrograms aroclor 1254/kg body weight/day, respectively, 5 days/wk. the cynomolgus monkeys, which were mature monkeys with a poor breeding history, were treated for approximately 55 wk, wh ... | 1990 | 2125970 |
| internalization of human sex steroid-binding protein in the monkey epididymis. | human sex steroid-binding protein (hsbp) has been purified from late-pregnancy serum and labelled either by iodination (125i) or by photoaffinity with [3h]delta 6-testosterone. using a micromanipulator, each labelled protein was separately injected into the lumen of epididymal tubules isolated from the head epididymis of the cynomologus monkey (macaca fascicularis). tubules were sampled from 3 to 90 min after the injection and processed for electron microscope autoradiography. localization of th ... | 1990 | 2126929 |
| thrombin activity induced by balloon angioplasty of the coronary artery in macaca fascicularis (cynomolgus monkey). | in this paper we address the question of whether balloon angioplasty induces thrombin action. in the studies reported here we measured fibrinopeptide a levels in a group of atherosclerotic monkeys undergoing coronary angioplasty. a blood collection catheter was introduced into the inferior vena cava through a femoral vein, and the angioplasty catheter introduced via the femoral artery. heparin was administered immediately after insertion of the arterial catheter. serial blood samples were collec ... | 1990 | 2133227 |
| the fiber system of the choroidocapillaris. | in the central choroid of three cynomolgus monkeys (macaca irus) and a baboon (papio anubis) the shape of the choroidocapillary sinus is determined by a system of interstitial collagen fibers, the "fiber system of the choroidocapillaris". the inner leaflet of this system is bruch's membrane. the outer leaflet consists of interwoven collagen bundles, covering the roof of the capillary sinus. straight bundles of collagen fibers passing through connective tissue columns in the choroidocapillary sin ... | 1990 | 2134375 |
| metabolic processing and carcinogenicity of heterocyclic amines in nonhuman primates. | the potential for human exposure to heterocyclic amine (haa) mutagens derived from cooking food prompted an evaluation of the disposition and carcinogenicity of three of the haas in nonhuman primates, especially cynomolgus monkeys. the three haas currently under study are 2-amino-3-methylimidazo [4, 5-f]quinoline (iq), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (8-meiqx) and 2-amino-1-methyl-6-phenylimidazo [4,5,b]pyridine (phip). these three haas were selected on the basis of several factors ... | 1990 | 2134682 |
| activity of the short-acting thromboxane receptor antagonist, sq 30,741, in thrombolytic and vasospastic models in monkeys. | the effects of the thromboxane receptor antagonist sq 30,741 (1 mg/kg) on reflow after thrombolysis and on vasoconstrictor responses to the thromboxane agonist u-46,619 was determined in cynomolgus monkeys. sq 30,741 (n = 5) or vehicle (n = 4) was administered to anesthetized monkeys upon reocclusion of a stenotic and electrically injured carotid artery, which had been recanalized successfully with streptokinase and heparin. once blood flow again decreased to zero the treatment was repeated. sq ... | 1990 | 2140131 |
| fluorescent and biotin probes for dopamine receptors: d1 and d2 receptor affinity and selectivity. | fluorophor and biotin derivatives of dopamine agonist and antagonist drugs were synthesized and evaluated for binding affinity and selectivity at d1 and d2 dopamine receptors in membranes prepared from monkey (macaca fascicularis) caudate putamen. binding was measured using [3h]sch 23390 to label d1 receptors and [3h]spiperone to label d2 receptors. the selective d1 antagonist skf 83566, whether coupled to 7-nitrobenz-2-oxa-1,3-diazole-4-yl (nbd), to fluorescein, or to biotin retained high affin ... | 1990 | 2141665 |
| xenogeneic proliferation and lymphokine production are dependent on cd4+ helper t cells and self antigen-presenting cells in the mouse. | we studied proliferation and interleukin 2 production by b6 mouse spleen cells in response to stimulation by irradiated cynomolgus monkey spleen cells and compared the results with responses against whole mhc-disparate allogeneic controls (balb/c). we found that (a) primary xenogeneic helper responses were absent, whereas primary allogeneic responses were brisk, (b) secondary xenogeneic helper responses were dependent on cd4+ t cells and responder antigen-presenting cells (apcs), whereas allogen ... | 1990 | 2142721 |
| effects of topical applications of meclofenamic acid and ibuprofen on bone loss, subgingival microbiota and gingival pmn response in the primate macaca fascicularis. | nonsteroidal anti-inflammatory drugs (nsaids) have been shown to alter periodontitis in both animals and humans. this study was initiated in the nonhuman primate (nhp) model to determine the effect of two nsaids on preexisting gingivitis, the conversion of gingivitis to periodontitis, the associated subgingival microbiota, and the gingival pmn response. eighteen cynomolgus monkeys were divided into three groups and treated on a blind basis with ibuprofen 8%, meclofenamic acid 5%, or placebo appl ... | 1990 | 2145415 |
| evaluation of the mechanisms responsible for the reduction in erythrocyte complement receptors when immune complexes form in vivo in primates. | patients with immune complex-(ic) mediated diseases frequently have low levels of cr1 on e. the present study was undertaken to determine the role of circulating ic in causing low e-cr1 levels. e-cr1 were enumerated by measuring the binding of anti-cr1 mab (e11) and rabbit anti-cr1 antibodies (rbacr1) to e. in addition, the distribution of cr1 among e was assessed by flow cytometry of e stained with e11 and rbacr1 and by evaluating the binding of e11-coated fluorescent beads (e11-beads) to e. e1 ... | 1990 | 2147938 |
| uptake of medroxyprogesterone acetate by progestin and androgen target neurons in the brain and pituitary gland of male cynomolgus monkeys. | medroxyprogesterone acetate (mpa), a synthetic progestin that reduces plasma testosterone levels, has been used in the treatment of male sex offenders. it also reduces the sexual activity of male macaques. to investigate its sites and mechanisms of action, 11 adult male cynomolgus monkeys were castrated and 7 and 21 h later were pretreated with 20 mg progesterone s.c. (prog, n = 3), or 5 mg dihydrotestosterone propionate s.c. (dhtp, n = 3) or oil vehicle (controls, n = 5). twenty-four hours afte ... | 1990 | 2149428 |
| serological survey for two simian retroviruses in macaques and african green monkeys. | colonies of nonhuman primates at the bowman gray school of medicine (bgsm) were tested for antibodies to two retroviruses associated with immunodeficiency by indirect immunofluorescence (ifa) and western blot. a total of 471 cynomolgus macaques (macaca fascicularis), 144 rhesus monkeys (m. mulatta) and 67 stumptail monkey m. arctoides) were tested for srv-1, and 152 african green monkeys (cercopithecus aethiops) were tested for siv. of the macaques tested, 170 (36%) cynomolgus, 5 (3%) rhesus and ... | 1990 | 2153854 |
| molecular genetic analysis of actinobacillus actinomycetemcomitans epidemiology. | research over the past decade has identified many of the microorganisms involved in the etiology of human periodontitis such as actinobacillus actinomycetemcomitans. efforts are now directed toward defining these species' role in the pathogenic process. since microbial colonization of host tissues is a key first step in developing a bacterial infection, determining the source of the periodontal pathogens and their route of transmission is likely to be crucial in formulating preventive strategies ... | 1990 | 2156041 |
| recrudescence of entopolypoides macaci mayer, 1933 (babesiidae) infection secondary to stress in long-tailed macaques (macaca fascicularis). | parasites were found in red blood cells of two long-tailed macaques (macaca fascicularis) imported from indonesia and housed in the washington regional primate research center breeding colony for 7 years or longer. both macaques developed parasitemias secondary to stress (type d retrovirus in one case and severe trauma in the other). entopolypoides macaci (babesiidae) was diagnosed on the basis of morphology from peripheral blood smears stained with wright's stain. antibodies against babesia sp. ... | 1990 | 2157097 |
| early gastric cancer induced by n-ethyl-n'-nitro-n-nitrosoguanidine in a cynomolgus monkey six years after initial diagnosis of the lesion. | a signet ring cell carcinoma in the gastric antrum of a cynomolgus monkey induced by n-ethyl-n'-nitro-n-nitrosoguanidine was sequentially studied by endoscopy, biopsy, and autopsy. the carcinoma was first detected on the angulus of the stomach at the 38th month as a slightly elevated lesion. sixty-one months later this tumor was found to be still in the "early" (intramucosal) stage. another, independent, initial gastric cancer was also discovered. this is the first example of an induced gastric ... | 1990 | 2157693 |
| establishment of a b-lymphoblastoid cell line infected with epstein-barr-related virus from a cynomolgus monkey (macaca fascicularis). | a b-lymphoblastoid cell line (ts-b) was established from lymph nodes of an apparently healthy cynomolgus monkey. the cells were demonstrated to contain epstein-barr virus-related antigens. moreover, herpesvirus particles were found in the cells by electron microscopy. the cell-free culture medium transformed lymphocytes of cynomolgus rhesus monkeys, and of japanese monkeys. | 1990 | 2160013 |
| experimental infection of african green monkeys and cynomolgus monkeys with a sivagm strain isolated from a healthy african green monkey. | an infection occurred in all african green monkeys and cynomolgus monkeys experimentally inoculated with sivagm [tyo-1], as demonstrated by the appearance of an antibody to sivagm [tyo-1] and the isolation of the virus. no monkey exhibited overt clinical disorders throughout the experimental period of 42 weeks. thus, sivagm was not pathogenic to its original host or to macaques. this system is proposed as a model for hiv infection manifesting no overt disease. | 1990 | 2160015 |
| experimental group a rotaviral infection in cynomolgus monkeys raised on formula diet. | rotaviral infections in cynomolgus monkeys (macaca fasicularis) were studied to ascertain its suitability as a model of infection and diarrhea caused by group a human rotaviruses. formula-fed monkeys were used as they could be observed closely. experimental rotaviral infection of cynomolgus monkeys was age-dependent; only young monkeys were readily infected. formula-fed newborns were readily infected with cell-culture-adapted human (wa) and simian (sa11) viruses and with a rotavirus from a human ... | 1990 | 2161071 |
| the use of the polymerase chain reaction for the detection of simian immunodeficiency virus in experimentally infected macaques. | a rapid, non-radioactive assay for the detection of proviral simian immunodeficiency virus (siv) in tissue-culture cells is described. the assay is based on the co-amplification of the siv env and gag genes by the polymerase chain reaction (pcr). when the gag pcr product is blotted onto a nylon membrane and hybridised to a radioactive oligonucleotide probe, the assay can also be used to detect the siv gag gene in dna isolated directly from experimentally infected cynomolgus macaque lymphocytes. ... | 1990 | 2161421 |
| accuracy and reproducibility of lumbar bone mineral status determined by dual photon absorptiometry in live male cynomolgus macaques (macaca fascicularis). | dual photon absorptiometry (dpa) was used to determine the in vivo bone mineral content (bmc) and bone mineral density of lumbar vertebrae (l2-4) in feral adult male cynomolgus macaques (macaca fascicularis, n = 20). following in vivo dpa scans, all animals were euthanized and the lumbar spine segment excised. the excised lumbar vertebrae, plus spinal cord, were formalin-fixed and measured three times by ex vivo dpa. the first ex vivo scan matched the monkey's own in vivo soft tissue beam attenu ... | 1990 | 2162981 |
| the production and purification of pcr-derived recombinant simian immunodeficiency virus p27 gag protein; its use in detecting serological and t-cell responses in macaques. | the polymerase chain reaction (pcr) was used to amplify a region of the gag gene, encompassing the core protein p27, from genomic dna of cells infected with sivmac251 (32h isolate). the 767 base pair pcr product was cloned into the bacteriophage m13 and fully sequenced before sub-cloning into the expression vector puc19. the 30 kilodalton (kda) fusion protein of lacz-p27 was expressed as a soluble protein in e. coli jm101 cells and purified to greater than 90% purity by affinity chromatography. ... | 1990 | 2166751 |
| mapping of mutations associated with neurovirulence in monkeys infected with sabin 1 poliovirus revertants selected at high temperature. | poliovirus type 1 neurovirulence is difficult to analyze because of the 56 mutations which differentiate the neurovirulent mahoney strain from the attenuated sabin strain. we have isolated four neurovirulent mutants which differ from the temperature-sensitive parental sabin 1 strain by only a few mutations, using selection for temperature resistance: mutant s(1)37c1 was isolated at 37.5 degrees c, s(1)38c5 was isolated at 38.5 degrees c, and s(1)39c6 and s(1)39c10 were isolated at 39.5 degrees c ... | 1990 | 2168976 |
| carbon-11 labelling of eticlopride in two different positions--a selective high-affinity ligand for the study of dopamine d-2 receptors using pet. | a new highly selective high-affinity dopamine d-2 receptor antagonist, eticlopride ((-)-(s)-5-chloro-3-ethyl-n-((1-ethyl-2-pyrrolidinyl) methyl)-6-methoxysalicylamide), was labelled with 11c in two different positions ([n-ethyl-11c]eticlopride (i)) and ([methyl-11c]eticlopride (ii)). product i was prepared by n-alkylation of the n-desethyl compound with [11c]ethyl iodide. ii was prepared by o-alkylation of the diphenolic precursor with [11c]methyl iodide followed by separation of the two methyla ... | 1990 | 2170298 |
| long term vascular catheterization of the cynomolgus monkey. | 1990 | 2170757 | |
| metabolism of cysteinyl leukotrienes in monkey and man. | the proinflammatory cysteinyl leukotrienes are inactivated in primates by (a) intravascular degradation, (b) hepatic and renal uptake from the blood circulation, (c) intracellular metabolism of leukotriene e4 (lte4), and (d) biliary and renal excretion of ltc4 degradation products. we have analyzed cysteinyl leukotriene metabolites excreted into bile and urine of the monkey macaca fascicularis and of man. in both species, hepatobiliary leukotriene elimination predominated over renal excretion. i ... | 1990 | 2174780 |
| patterns of cerebral cortex mrna expression. | a pool of 163 clones, isolated by screening 60,000 members of a macaca fascicularis cerebral cortex cdna library with a cortex-minus-cerebellum subtracted probe prepared by the phenol enhancement method, was analyzed by northern blot hybridization studies. one hundred fifty-three of these clones corresponded to 22 rnas whose abundance was at least 2-fold higher in cerebral cortex poly(a)+ rna samples than in samples of cerebellar poly(a)+ rna. seven of these rnas, represented by 131 clones, were ... | 1990 | 2174979 |
| [the sensitivity of rhesus and cynomolgus macaques to the human hepatitis a virus]. | hepatitis a infection characterized by virus excretion in feces, synthesis of specific igm antibody, increased activity of alanine aminotransferase in the blood serum, and a complex of morphological lesions in the liver typical of acute hepatitis was reproduced in m. fascicularis (m. f.) and macaca rhesus (m. r.) using 2 strains of hepatitis a virus (hav) isolated from human patients. the incubation period varying from 9 to 23 (mean 16) days in m. f. and from 12 to 35 (mean 18) days in m. r. in ... | 1990 | 2175064 |
| can atherosclerotic plaques regress? anatomic and biochemical evidence from nonhuman animal models. | for at least 60 years, spotty and poorly documented evidence has suggested that atherosclerotic disease in humans might be reversible. little direct evidence was available until researchers demonstrated that rather advanced atherosclerotic lesions in experimental animals could show marked improvement after blood-lipid-reducing regimens that were often combined with other measures, such as increased ambient oxygen and estradiol therapy. in fact, this combination was used in this laboratory to pro ... | 1990 | 2180269 |
| oral contraceptive administration, interfemale relationships, and sexual behavior in macaca fascicularis. | the effects of oral contraceptive administration on the social relationships of adult female cynomolgus monkeys (macaca fascicularis) were examined. ten females were administered ethinyl estradiol/ethynodiol diacetate (demulen), 10 were administered ethinyl estradiol/norgestrel (ovral), and 10 served as a control group. the monkeys lived in social groups of 5 females each, and patterns of social interaction and social status were recorded. interfemale relationships were also observed when a vase ... | 1990 | 2186714 |
| effects of parenteral recombinant human macrophage colony-stimulating factor on monocyte number, phenotype, and antitumor cytotoxicity in nonhuman primates. | recombinant human macrophage colony-stimulating factor (rhm-csf) was given to cynomolgus monkeys by continuous intravenous infusion or subcutaneous injection, at a dose of 50 to 100 micrograms/kg/d in repetitive 14-day cycles. starting within 24 to 48 hours of initiation of rhm-csf, there was a progressive increase in the number of circulating monocytes, from a baseline of 811 +/- 253 cells/microl to a peak of 3,495 +/- 712 cells/microl on day 5 to 7. many of these cells were large, granular, an ... | 1990 | 2186820 |
| primate trabeculectomies with 5-fluorouracil collagen implants. | bilateral trabeculectomies were performed on four normal cynomolgus monkeys. highly purified bovine skin collagen implants with either 1 mg of 5-fluorouracil or physiologic saline (one each per monkey by randomized, masked assignment) were sutured under the scleral flaps. the randomization code was not broken until all clinical and histopathologic observations had been completed. six weeks postoperatively, the 5-fluorouracil-treated eyes had more deeply open internal trabeculectomy ostia than th ... | 1990 | 2189316 |
| autoradiographic studies in animal models of hemi-parkinsonism reveal dopamine d2 but not d1 receptor supersensitivity. ii. unilateral intra-carotid infusion of mptp in the monkey (macaca fascicularis). | the selective dopaminergic antagonist ligands [3h]sch 23390 and [3h]sulpiride were used to reveal autoradiographically dopamine d1 and d2 receptors, respectively, in brain sections from monkeys which had received unilateral intracarotid infusions of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), causing loss of dopamine-containing neurones of the substantia nigra pars compacta. the monkeys developed hemi-parkinsonian symptoms (tremor, bradykinesia) in limbs contralateral to the side of the ... | 1990 | 2192772 |
| in vivo and in vitro modulation of gonadotropin-releasing hormone metabolism by estradiol and progesterone. | the metabolism of gnrh by membrane-bound and serum-degrading enzymes may play an important role in the regulation of pituitary gonadotropin secretion. we examined gnrh metabolism by pituitary cells in vitro and the metabolism of exogenously administered gnrh in vivo in the presence and absence of estradiol (e2) and progesterone (p4). ovariectomized cynomolgus monkeys were implanted with e2- and/or p4-filled silastic capsules to simulate the estrogen and progesterone patterns of the normal menstr ... | 1990 | 2193798 |
| [diagnosis of abortion and fetal death by the ultrasonographical device in cynomolgus monkeys under indoor individually-caged conditions]. | this paper describes the rate of naturally occurring abortion and fetal death that were diagnosed by the use of an ultrasonographical device in 683 pregnant cynomolgus monkeys (macaca fascicularis) of which 542 were wild-imported monkeys and 141 were colony-bred monkeys. all of these animals had become pregnant by the 3-day timed mating system. the combined rate of abortion and fetal death was 7.0% in the wild-imported animals and 7.8% in the colony-bred animals. there were no significant differ ... | 1990 | 2193816 |
| control of retinal and choroidal blood flow. | earlier studies on the control of retinal and choroidal blood flow are reviewed and some recent observations on the effects of light on retinal metabolism and retinal and choroidal blood flow in monkeys (macaca fascicularis) are reported in preliminary form. the retina is nourished by the retinal blood vessels, where blood flow is autoregulated and the choroidal blood vessels where autoregulation is absent. studies with the deoxyglucose method of sokoloff indicate that flickering light tends to ... | 1990 | 2199239 |
| the psychopharmacology of 5-ht3 receptors. | the review presents evidence that 5-ht3 receptors within the brain may contribute to the control of behavior. 5-ht3 receptor antagonists gr38032f, zacopride, ics 205-930 and other agents are very potent in reducing mesolimbic dopamine hyperactivity caused by the injection of amphetamine or infusion of dopamine into the rat nucleus accumbens and amygdala, and the ventral striatum of the marmoset. such actions are distinguished from those of neuroleptic agents by a failure to reduce normal levels ... | 1990 | 2203069 |
| [role of doppler velocimetry in diagnosis of tmj dysfunction. 1. experimentation on macaca fascicularis]. | the aim of this work has been to demonstrate that the tracing obtained by doppler examination is the graphic representation of the movement and the speedy of the condyle and the disk. in order to achieve this result we have proved doppler examination first of all on entire tmj of a macaca fascicularis monkey and than on the same joint without the disk. | 1990 | 2205793 |
| intrauterine insemination with ultrasound guidance in the long-tailed macaque (macaca fascicularis). | techniques used for the artificial insemination of macaques have primarily involved instillation of the ejaculate into the vagina or cervical canal. intrauterine insemination has been performed previously but only as a surgical procedure. the application of ultrasound-guided techniques for this purpose provides a method for efficiently inseminating macaques in a relatively noninvasive fashion. this report describes the successful transabdominal ultrasound-guided insemination of the long-tailed m ... | 1990 | 2213853 |
| spontaneously occurring congenital polycystic kidney in a cynomolgus monkey (macaca fascicularis). | congenital polycystic kidney disease was diagnosed at necropsy in a stillborn male cynomolgus monkey (macaca fascicularis). this case was very similar to infantile polycystic kidney disease in man and the rhesus monkey, except that no increase in number of intrahepatic bile ducts was observed. | 1990 | 2213859 |
| fluid movement across the blood-retinal barrier: a review of studies by vitreous fluorophotometry. | vitreous fluorophotometry was used to study the fluid movement across the blood-retinal barrier. the effect of plasma osmolality and intraocular pressure on the movement of the fluorescent tracer confirmed the interaction between the tracers and the fluid flow across the blood-retinal barrier. the measurement of outward and inward permeabilities to carboxyfluorescein revealed the existence of a posteriorly directed fluid flow in the vitreous cavity of cynomolgus monkey eyes with retinal detachme ... | 1990 | 2214357 |
| regulation of plasma corticosteroid-binding globulin in adult cynomolgus monkey (macaca fascicularis) during different reproductive states. | the plasma concentration of the corticosteroid-binding globulin (mcbg) has been measured in macaca fascicularis, during different stages of reproduction and under hormonal treatments. the mcbg level was determined by a specific electroimmunoassay. there was no difference between females in the follicular phase and intact males; mcbg concentrations were respectively (mean +/- sem) 469 +/- 53 and 443 +/- 25.6 nmol/l. the mcbg levels levels were similar during both the luteal (469 +/- 33.5 nmol/l) ... | 1990 | 2214775 |
| ultrastructure of interstitial cells of cajal at the gastro-oesophageal junction of the monkey (macaca fascicularis). | the ultrastructure of the interstitial cells of cajal (icc) in the oesophagus of the monkey resembled that described in the oesophagus of other mammalian species but differed in their paucity and almost lack of smooth endoplasmic reticulum, caveolae and filaments. the plasmalemma of the icc was in close contact (20- to 30-nm gaps) with that of smooth muscle cells. this may occasionally take the form of a desmosome, but gap junctions have not been observed. vesiculated axon profiles, containing l ... | 1990 | 2220289 |
| oral contraceptives, lipoproteins, and atherosclerosis. | a nonhuman primate model was developed to study the effects of oral contraceptives on lipoproteins and atherosclerosis. cynomolgus macaques were selected because of their susceptibility to diet-induced atherosclerosis and because their reproductive physiology, menstrual cycle, and circulating sex hormone patterns are similar to those of human females. the first study compared a vaginal ring containing levonorgestrel and estradiol with an oral contraceptive containing norgestrel and ethinyl estra ... | 1990 | 2220963 |
| changes in the behaviour of wild long-tailed macaques (macaca fascicularis) after encounters with a model python. | 1990 | 2227721 | |
| evaluation of two monkey species (macaca mulatta and macaca fascicularis) as possible models for human helicobacter pylori disease. | endoscopic, histologic, and microbiologic evaluations of 21 cynomolgus and 34 rhesus monkeys for naturally occurring helicobacter pylori infection were done. h. pylori was never isolated from any cynomolgus monkey, but was found in 12 rhesus monkeys. a general correlation existed between a positive culture and a gastric inflammatory response. inoculation challenges were then undertaken. four cynomolgus and five rhesus monkeys received two different h. pylori strains isolated from humans. five rh ... | 1990 | 2229353 |
| use of immunoelectron microscopy to show ebola virus during the 1989 united states epizootic. | a filovirus, serologically related to ebola virus, was detected by "post-embedment" immunoelectron microscopical examination of ma-104 cells. these had been infected by inoculation with serum samples obtained during the 1989 epizootic in cynomolgus monkeys (macaca fascicularis), imported from the philippines and maintained at reston, virginia, usa, a primate holding facility. the immunoelectron microscopy method, when used in conjunction with standard transmission electron microscopy (tem) of in ... | 1990 | 2229429 |
| primary structure and anticandidal activity of the major histatin from parotid secretion of the subhuman primate, macaca fascicularis. | a major macaque histatin (m-histatin 1) from the parotid secretion of the subhuman primate, macaca fascicularis, was isolated by gel filtration on bio-gel p-2 and purified to homogeneity by reversed-phase high-performance liquid chromatography on a tsk-ods c18 column. the complete amino acid sequence of m-histatin 1, determined by automated edman degradation, is: (formula; see text) m-histatin 1 contains 38 amino acid residues, a phosphoserine at residue 2, has a molecular weight of 4881.8, a ca ... | 1990 | 2229609 |
| amygdalar interaction with the mediodorsal nucleus of the thalamus and the ventromedial prefrontal cortex in stimulus-reward associative learning in the monkey. | cynomolgus monkeys (macaca fascicularis) were assessed for their ability to associate visual stimuli with food reward. they learned a series of new 2-choice visual discriminations between colored patterns displayed on a monitor screen. the feedback for correct choice was the delivery of food. in order to promote associative learning between the visual stimuli and the incentive value of the food reward, reward delivery was not accompanied by any distinctive visual feedback on the display screen. ... | 1990 | 2230939 |
| histopathological changes in simian immunodeficiency virus infection. | the histological lesions were studied in seven rhesus and three cynomolgus monkeys infected with simian immunodeficiency virus for periods ranging from nine weeks to 18 months. lymphoreticular changes included hyperplasia, follicular involution and depletion, and one animal had amyloidosis of the spleen. hyperplastic changes also took place in mucosa-associated lymphoid tissue and infiltrations occurred in the vaginal mucosa of one animal, which could be significant in sexual transmission of the ... | 1990 | 2231195 |
| inoculation of macaca fascicularis with simian immunodeficiency virus, sivmne immunologic, serologic, and pathologic changes. | previous studies had tested the susceptibility of two macaque species, macaca nemestrina and m. mulatta, to infection with the primate lymphotropic lentivirus sivmne. in this report we describe the results obtained after infecting eleven m. fascicularis with sivmne. six of the animals had previously been immunized with a recombinant vaccinia virus expressing the envelope gene of hiv-1. all eleven animals became seropositive. to date ten animals have died 43 to 155 weeks post infection of an aids ... | 1990 | 2231689 |
| determination of retinal blood velocity with respect to the cardiac cycle using laser-triggered release of liposome-encapsulated dye. | a system of selective angiography has been developed for measuring blood velocity in retinal arteries and veins. it uses a liposome-encapsulated fluorescent dye that is released by application of laser energy in a specific retinal vessel. the method is shown to be able to distinguish between peak systolic velocity and minimum diastolic velocity. in the cynomolgus monkey, the two values were found to differ by approximately a factor of three. it is known that many ocular and systemic diseases aff ... | 1990 | 2233102 |
| nerve growth factor in the primate central nervous system: regional distribution and ontogeny. | an enzyme immunoassay for nerve growth factor was developed to determine the regional distribution and ontogenic change in the macaque (macaca fascicularis) cns. the standard curve of mouse nerve growth factor paralleled the dilution curves of extracts from the primate cns at the adult and pre-natal stages. furthermore, the nerve growth factor immunoreactive material comigrated with mouse nerve growth factor by means of carboxy methyl cellulose chromatography. these findings suggest that the imm ... | 1990 | 2234406 |
| use of yttrium-90-labeled anti-tac antibody in primate xenograft transplantation. | the high-affinity interleukin-2 receptor (il-2r) is expressed by t cells activated in response to foreign histocompatibility antigens but not by normal resting cells. thus, blockade of the interaction of il-2 with its receptor could achieve selective immunosuppression. accordingly, anti-tac, a murine igg2a class monoclonal antibody specific to the il-2r, was used alone or in a chelated form with yttrium-90 (90y), a pure beta emitter, to inhibit rejection of cardiac xenografts from macaca fascicu ... | 2007 | 2238051 |
| increase in vertical dimension by interpositional bone grafts and subsequent craniofacial growth in adolescent monkeys. | the purpose of this study was to investigate the relationship between craniofacial growth and total maxillary osteotomy in adolescent macaca fascicularis monkeys. the monkeys' facial height was increased with the help of interpositional bone grafts. four monkeys underwent surgical procedures, and five served as controls. the changes in growth after surgery were then assessed with the help of conventional cephalometry and osseous implants. lateral cephalometric radiographs of all monkeys were tak ... | 1990 | 2239844 |
| synaptic junctions between sympathetic axon terminals and pinealocytes in the monkey macaca fascicularis. | the distribution of axon terminals in the pineal gland of monkeys was studied by electron microscopy. numerous terminals bearing small pleomorphic agranular and dense-cored vesicles were localized in the perivascular space and among the pinealocytes in the parenchyma in normal monkeys. following bilateral superior cervical ganglionectomy, they underwent degenerative changes, including the accumulation of glycogen masses, appearance of dense residual bodies and the displacement of synaptic vesicl ... | 1990 | 2240592 |
| [visual function of cynomolgus monkeys with macula degeneration and peripheral retinal degeneration]. | using the simplified method for judging visual function of the cynomolgus monkey that was established by the present authors (suzuki et al., 1988), forty-four cynomolgus monkeys with normal ophthalmoscopic findings, eleven monkeys with macula degeneration and thirteen monkeys with peripheral retinal degeneration were examined for their visual function. it was demonstrated that the monkeys with macula degeneration were inferior in their visual function to the monkeys with normal fundus. in additi ... | 1990 | 2242769 |
| absence of time-dependent facility increase ("washout") in the perfused enucleated human eye. | during the course of constant-pressure anterior chamber perfusion experiments in eyes from a number of species, measured outflow facility increases progressively with perfusion time. one possible explanation for this phenomenon has been that the technique of perfusion induces a loss of extracellular material from the outflow pathway. therefore, this general observation has been termed the "wash-out" effect. data from the authors' laboratories demonstrate that although outflow facility increases ... | 1990 | 2243003 |
| effects of prostaglandins f2 alpha, a2, and their esters in glaucomatous monkey eyes. | the effect of prostaglandin (pg) f2 alpha-isopropyl ester (ie), pga2, or pga2-ie on intraocular pressure (iop) was tested in eight cynomolgus monkey eyes with argon laser-induced glaucoma. dose-response testing and baseline iop measurements were done. for multiple dose testing, 5 micrograms in 25 microliters (0.02%) of each pg was topically applied twice daily for 5 days. the iop was measured at 30- or 60-minute intervals for 6 hours after the morning dose each day. a significant (p less than 0. ... | 1990 | 2243010 |
| visual receptive field organization and cortico-cortical connections of the lateral intraparietal area (area lip) in the macaque. | the visual receptive field physiology and anatomical connections of the lateral intraparietal area (area lip), a visuomotor area in the lateral bank of the inferior parietal lobule, were investigated in the cynomolgus monkey (macaca fascicularis). afferent input and physiological properties of area 5 neurons in the medial bank of the intraparietal sulcus (i.e., area pea) were also determined. area lip is composed of two myeloarchitectonic zones: a ventral zone (lipv), which is densely myelinated ... | 1990 | 2243159 |
| inhibition of coronary artery atherosclerosis by 17-beta estradiol in ovariectomized monkeys. lack of an effect of added progesterone. | although controversy continues, the preponderance of evidence indicates that estrogen replacement therapy favorably influences the risk of coronary heart disease in postmenopausal women. it remains uncertain how this effect is mediated and whether the cyclic addition of a progestin may influence adversely an estrogen-related cardioprotective effect. we investigated the influence of sex hormone replacement therapy on diet-induced coronary artery atherosclerosis in estrogen-deficient (ovariectomiz ... | 1990 | 2244855 |
| vascular responses to endothelin-1 in atherosclerotic primates. | endothelin-1 (et-1) is a vasoactive peptide that is released by endothelial cells. this study was performed to determine whether vascular responses to et-1 are altered by atherosclerosis. et-1 (1 or 10 nmol) was injected intra-arterially into the perfused hind limb of normal cynomolgus monkeys and monkeys fed an atherogenic diet for 19 months. we calculated the resistance of the total limb and large arteries and estimated the resistance of the small vessels. the major finding was that et-1 had m ... | 1990 | 2244859 |
| effects of timolol on terbutaline- and vip-stimulated aqueous humor flow in the cynomolgus monkey. | the effects of timolol on terbutaline- and vip-stimulated aqueous humor flow were investigated in cynomolgus monkeys, with a labeled albumin dilution method. the maximal increase in aqueous humor flow caused by intracameral (100 micrograms/ml) or intravenous (0.4 micrograms/kg/min) administration of terbutaline was about 100%. the effect of intravenously infused terbutaline was completely abolished by intracameral administration of timolol, 0.1 mg/ml. the same dose of timolol also abolished the ... | 1990 | 2245647 |
| a novel regimen of gonadotropin-releasing hormone (gnrh) antagonist plus pulsatile gnrh: controlled restoration of gonadotropin secretion and ovulation induction. | using a primate model, we have tested a novel regimen of gonadotropin-releasing hormone (gnrh) antagonist plus pulsatile gnrh for the achievement of controlled restoration of gonadotropin secretion and ovulation induction. as a prelude, ovariectomized cynomolgus monkeys (n = 3) were treated with antide ([n-ac-d-nal(2)1, d-pcl-phe2, d-pal(3)3, lys(nic)5, d-lys(nic)6, lys(ipr)8, d-ala10]-gnrh) (3 mg/kg per day) for 6 consecutive days. on the 7th day, pulsatile gnrh therapy was initiated in a 7 day ... | 1990 | 2245840 |
| oscillatory activity of single units in a somatosensory cortex of an awake monkey and their possible role in texture analysis. | neuronal activity was extracellularly recorded in the cortex of an awake monkey (macaca fascicularis). single units displaying oscillatory firing patterns were found in the upper bank of the lateral sulcus in a region where most of the neurons responded to somatosensory stimuli. the spectral energies of the oscillating activity were distributed in a trimodal fashion--0-15, 15-50, and 80-250 hz--with the most common frequencies around 30 hz. the oscillatory activity was not affected by anesthesia ... | 1990 | 2247469 |
| cryopreservation of spermatozoa from cynomolgus monkeys (macaca fascicularis). | three egg-yolk diluents, which have been used successfully in cryopreservation of human spermatozoa, were compared for their ability to protect macaque semen against cryodamage. test (tes + tris + egg yolk), test with 20% skim milk (tsm), and egg yolk-citrate (eyc), each with 3 or 5% glycerol were compared using 12 ejaculates from 6 male cynomolgus macaques. computer-aided analysis of sperm motion was used to determine the percentage motility (%m), curvilinear velocity (vcl), and linearity (lin) ... | 1990 | 2250234 |
| [the effect of highly intensive irradiation on the functional status of the brain in monkeys]. | in experiments with macaca fascicularis a study was made of early manifestations of the central nervous system (cns) disturbances caused by exposure to 24 mev electrons (45 gy). the results obtained permit us to distinguish two main ways (stereotypes) by which a clinical picture of early postirradiation period develops: "comatose" and "non-comatose". a general clinical characteristic of each stereotype and stages of their development are presented. the postirradiation disturbances of nervous and ... | 1990 | 2251349 |
| striking absence of long-lasting effects of early color deprivation on monkey vision. | a monkey (macaca fascicularis) spent its first three months under far red illumination that made color vision impossible. it developed normal spectral sensitivity. in the present study we examined two aspects of color vision that presumably reflect cortical connectivity. in the first part of this article we show that chromatic induction was also unaffected: a blue surrounding made a gray target appear to be yellow to the monkey. at five months of age, the deprived monkey did not readily use colo ... | 1990 | 2253820 |
| in vitro fertilization in nonhuman primates. | ovulation induction, sperm capacitation, and fertilization have been studied for over 50 years in nonhuman primates but it has only been in the past 20 years that extensive studies on sizeable numbers of embryos have been carried out. of over 200 species of nonhuman primates only a few have been studied and the majority of the findings come from studies of the squirrel monkey, baboon, rhesus, and cynomolgus macaque. nevertheless, the fertilization process appears to be similar to that identified ... | 1990 | 2254914 |
| lead-induced behavioral impairment on a spatial discrimination reversal task in monkeys exposed during different periods of development. | a total of 52 monkeys (macaca fascicularis) were dosed orally with vehicle or 1.5 mg/kg/day of lead on one of four dosing regimens (13 monkeys/group): group 1, vehicle only; group 2, dosed with lead from birth onward; group 3, dosed with lead from birth to 400 days of age and vehicle thereafter; group 4, dosed with vehicle from birth to 300 days of age and lead thereafter. blood lead concentrations averaged 3-6 micrograms/dl when monkeys were not being dosed with lead, 32-36 micrograms/dl when b ... | 1990 | 2256120 |
| new non-steroidal aromatase inhibitors: focus on r76713. | r76713 is a novel triazole derivative which selectively blocks the cytochrome p450-dependent aromatase. in human placental microsomes, in fsh-stimulated rat and human granulosa cells and in human adipose stromal cells, 50% inhibition of estradiol biosynthesis was obtained at drug concentrations of 2-10 nm. in pmsg-injected female rats, r76713 lowered plasma estradiol levels by 50 and 90% 2 h after single oral doses of 0.005 and 0.05 mg/kg respectively. after 1 mg/kg, estradiol levels were suppre ... | 1990 | 2257238 |
| changes in excitability of motor units during preparation for movement. | single biceps motor units were recorded in two awake monkeys (macaca fascicularis) during the preparation for and execution of a forearm flexion movement. the motor sequence was organized as follows: after a control period lasting 500 ms, the animal was informed that a preparatory period (pp) was beginning by a preparatory signal (ps) consisting of diffuse sound and light. one to 1.5 s later, the animal was instructed by a bright light response signal (rs) to perform a rapid forearm flexion move ... | 1990 | 2257902 |
| light microscopic and ultrastructural analysis of gaba-immunoreactive profiles in the monkey spinal cord. | it is hypothesized that terminals containing gamma-aminobutyric acid (gaba) participate in presynaptic inhibition of primary afferents. to date, few convincing gaba-immunoreactive (gaba-ir) axo-axonic synapses have been demonstrated in support of this theory. the goal of this study is to document the relationship between gaba-ir profiles and central terminals in glomerular complexes in lumbar cord of the monkey (macaca fascicularis). in addition, the relationship between gaba-ir profiles and oth ... | 1990 | 2258461 |
| gustatory responses of single neurons in the caudolateral orbitofrontal cortex of the macaque monkey. | 1. in recordings made from 3,120 single neurons, a secondary cortical taste area was found in the caudolateral part of the orbitofrontal cortex of the cynomolgus macaque monkey, macaca fascicularis. the area is part of the dysgranular field of the orbitofrontal cortex and is situated anterior to the primary cortical taste areas in the frontal opercular and adjoining insular cortices. 2. the responses of 49 single neurons with gustatory responses in the caudolateral orbitofrontal taste cortex wer ... | 1990 | 2258734 |
| spontaneous orofacial dyskinesias in a captive cynomolgus monkey: implications for tardive dyskinesia. | we describe a syndrome of spontaneous orofacial dyskinesias and cage stereotypies in a singly housed adult cynomolgus monkey never previously exposed to neuroleptic drugs. abnormal movements were readily suppressed by acute treatment with haloperidol (0.03-0.24 mg/kg i.m.) or sch23390 (0.05-0.2 mg/kg i.m.) but not by physostigmine (0.005-0.04 mg/kg i.m.) or scopolamine (0.0025-0.04 mg/kg i.m.). the symptomatology and response to pharmacological manipulations was indistinguishable from that previ ... | 1990 | 2259355 |
| angiographic study of induced cerebral aneurysms in primates. | five cynomolgus monkeys treated with unilateral carotid ligation, renal hypertension, and beta-aminopropionitrile feeding were studied repeatedly by cerebral angiography to clarify the growth process of saccular cerebral aneurysms. repeated angiography demonstrated saccular cerebral aneurysms in three of five monkeys; two aneurysms were found 15 months and a third 12 months after the operation. at autopsy, one saccular aneurysm was found to be bilocular in shape, and the others were unilocular. ... | 1990 | 2259401 |
| distribution of parvalbumin immunoreactivity in the visual cortex of old world monkeys and humans. | the macaque visual system has been frequently used as a model for understanding functional aspects of human vision. there are, however, few studies directly comparing biochemically defined neuronal populations in the visual cortex of the two species. in this study we compared the distribution and morphological features of the parvalbumin-immunoreactive neuronal subpopulation within humans and old world monkeys (macaca fascicularis and macaca mulatta) by using monoclonal antibodies against the ca ... | 1990 | 2262599 |
| plasma carotenoids of monkeys (macaca fascicularis and saimiri sciureus) fed a nonpurified diet. | the major carotenoid pigments in the plasma and in a common, nonpurified diet of two species of monkeys (macaca fascicularis and saimiri sciureus) were measured. the xanthophylls, lutein, zeaxanthin, alpha-cryptoxanthin, and beta-cryptoxanthin, were the principal carotenoids in both the diet and the plasma. lutein and zeaxanthin were abundant in the all-trans, the 9-cis, and the 13-cis geometrical isomers in the diet, but the 9-cis form was rarely measurable in plasma. however, the 13-cis isomer ... | 1990 | 2262812 |
| scanning electron microscopic study on the vasculature of the human anterior eye segment, especially with respect to the ciliary processes. | the architecture of the vasculature of the human anterior eye segment was studied by scanning electron microscopy of vascular resin casts. regarding the major vessels it was found that the perforating branches of the anterior ciliary arteries (aca) form an anastomozing circle which lies in the posterior portion of the ciliary muscle (intramuscular circle). the acas supply the outer and posterior parts of the ciliary muscle, partly the iris, and the peripheral choroid by recurrent aca branches. t ... | 1990 | 2265676 |
| acute parenteral neurotoxicity of domoic acid in cynomolgus monkeys (m. fascicularis) | to study the cns effects of domoic acid (d.a.), 6 adult cynomolgus monkeys (m. fascicularis) were dosed intraperitoneally (4 mg/kg) or intravenously (0.025-0.5 mg/kg) with d.a. obtained from cultured mussels contaminated with this neurotoxin. clinical signs of neurotoxicity were preceded by a short presymptomatic period (2-3 min) and an even shorter prodromal period (0.5-1 min). the symptomatic period proper was characterized by persistent chewing with frothing, varying degrees of gagging, and v ... | 1990 | 2268382 |
| force necessary to fracture the orbital floor. | current thought on the pathophysiology of orbital wall fractures postulates either a "hydraulic" or a "buckling" mechanism. evidence from cadaver, dried skull, and theoretical model studies supports both theories. no in vivo data, human or nonhuman primate, are available that quantitate the force necessary to fracture the orbital floor by either of the two mechanisms. we developed an apparatus that delivers quantifiable force only to the globe, without occluding the orbital opening or striking t ... | 1990 | 2268617 |
| the representation of social relations by monkeys. | monkeys recognize the social relations that exist among others in their group. they know who associates with whom, for example, and other animals' relative dominance ranks. in addition, monkeys appear to compare types of social relations and make same/different judgments about them. in captivity, longtailed macaques (macaca fascicularis) trained to recognize the relation between one adult female and her offspring can identify the same relation among other mother-offspring pairs, and distinguish ... | 1990 | 2269006 |
| [early transient incapacitation of monkeys exposed to high-energy electrons and gamma-irradiation in supralethal doses]. | irradiation of macaca fascicularis with electrons (24 mev, 46 and 104 gy) and gamma-quanta (60co, 77 and 138 gy) caused early transient incapacitation (eti) and severe symptoms of neurological disturbances. two types of the eti clinical patterns were distinguished: a dyskinetic type marked by ataxia; and a severer, comatose type manifested by disappearance of voluntary movements, areactivity, and temporary loss of reflexes. | 1990 | 2270282 |
| [the electrical activity of the monkey brain in the period of early transient incapacity during gamma-irradiation at high dose rates]. | changes in the electroencephalogram (eeg) of macaca fascicularis during early transient incapacitation (eti) were shown to correlate with the dynamics of clinical manifestations of the damage. irradiation caused desynchronization of eeg followed by a generalized retardation of its fluctuations reaching the maximum at the height of eti. eeg disturbances in animals during the comatose phase of eti indicated a severe inhibition of the brain cortex functional activity. | 1990 | 2270283 |
| developmental toxicity of temafloxacin hydrochloride in the long-tailed macaque (macaca fascicularis). | the potential developmental toxicity of temafloxacin hydrochloride was studied in the long-tailed macaque (macaca fascicularis). ten animals in each of the three drug-treated groups (25, 50, and 100 mg/kg) were administered temafloxacin via nasogastric intubation during gestational days (gd) 20-50. a control group of ten animals received vehicle only. the dams were monitored daily for adverse physical signs and maternal blood samples were collected for analyses of serum progesterone (p), 17 beta ... | 1990 | 2274889 |
| induction of malformations in the cynomolgus monkey with 13-cis retinoic acid. | the embryotoxic and teratogenic potential of 13-cis retinoic acid was assessed in the cynomolgus macaque (macaca fascicularis). a total of 41 animals was orally administered 13-cis retinoic acid in four sequential experiments. in exp. 1 three dose levels, 2, 10, and 25 mg/kg, were administered on gestational day (gd) 18-28; 5 mg/kg was administered as an equally divided dose twice daily in exp. 2 and 3 on gd 21-24 and on gd 25-27, respectively; in exp. 4 the drug was administered at 2.5 mg/kg on ... | 1990 | 2274892 |
| effect of nitecapone (or-462) on the pharmacokinetics of levodopa and 3-o-methyldopa formation in cynomolgus monkeys. | 3-o-methyldopa (omd) is the principal circulating metabolite formed from exogenously administered levodopa. we studied the effect of nitecapone (or-462), a novel inhibitor of catechol-o-methyltransferase (comt), on omd formation in cynomolgus monkeys following intravenous levodopa administration. the drug does not cross the blood-brain barrier, and therefore inhibits only peripheral omd formation. at a dose of 5 mg/kg, nitecapone reduced the area under the omd concentration-time curve by 50%. in ... | 1990 | 2276119 |
| experimental oral toxicity of domoic acid in cynomolgus monkeys (macaca fascicularis) and rats. preliminary investigations. | a recent outbreak of marine food poisoning in humans was attributed to the consumption of blue mussels (mytilus edulis l.) contaminated with domoic acid (da) that was produced by the diatom nitzschia pungens. the clinical and morphological effects of single oral doses of extracts of mussels contaminated with da or of da isolated from toxic mussels were investigated in small groups (one to six) of cynomolgus monkeys (macaca fascicularis; 0.5-10 mg da/kg body weight) and of sprague-dawley rats (60 ... | 1990 | 2276699 |
| incidence of visual cortical neurons which have axon collaterals projecting to both cerebral hemispheres during prenatal primate development. | fast blue was injected massively in extrastriate cortex of one hemisphere diamidino yellow in area 17 of the other hemisphere, in adult and prenatal cynomolgus monkeys. after a suitable survival period the brains were processed for fluorescent dyes. counts were made of the total number of labeled neurons and of those neurons which were labeled by both dyes and which project therefore to both hemispheres by means of bifurcating axon collaterals. at 122 and 135 days after conception (e122 and e135 ... | 1990 | 2279323 |
| effect of heat shock proteins on survival of isolated aortic cells from normal and atherosclerotic cynomolgus macaques. | alterations in the level and distribution of arterial heat shock proteins (hsps) have been demonstrated during atherogenesis. the significance of these changes within the developing and dying plaque, however, is not understood. to examine a potential protective effect of hsps on arterial cells, enzymatically isolated cells from normal and diet-induced atherosclerotic aortas of cynomolgus macaques were stressed for 20 h with and without added 72/73 kda heat shock proteins (hsp-72/73), over a rang ... | 1990 | 2282091 |
| correlation of noninvasive arterial compliance with anatomic pathology of atherosclerotic nonhuman primates. | fifteen cynomolgus monkeys were fed a control (n = 3) or cholesterol-containing diet (n = 12) for 26 months. an impedance plethysmograph and a calibrated volume plethysmograph were used to determine femoral arterial volume change, delta v, from femoral arteries. abdominal aorta pulse pressure was measured directly. the ratio of delta v to pulse pressure, delta p, defined femoral artery compliance. at necropsy, sections of pressure fixed common iliac, external iliac, femoral and carotid arteries ... | 1990 | 2282107 |
| evidence for coexistence between calcitonin gene-related peptide and serotonin in the bulbospinal pathway in the monkey. | by the use of the indirect immunofluorescence and in situ hybridization techniques, the distribution of calcitonin gene-related peptide (cgrp)-like immunoreactivity (li) and cgrp mrna was studied in the spinal cord as well as in the midline raphe nuclei and the hypoglossal nucleus in the medulla oblongata of the monkey (macaca fascicularis). in the spinal cord only a few large neurons in the motor nucleus contained cgrp-li, while a majority of the neurons in the hypoglossal nucleus contained cgr ... | 1990 | 2282533 |
| effect of the new potent lhrh antagonist antide. | the ability of the new lhrh antagonist antide to induce a long-term chemical castration in adult male rats and cynomolgus monkeys was investigated. the animals were treated subcutaneously with different doses either once or on 5 consecutive days. the effects on serum concentration of lh (only rat) and testosterone and on the weights of the testes, prostates and seminal vesicles were investigated after different periods of time. histological evaluation of testes, pituitary and hypothalamus was al ... | 1990 | 2285607 |
| anabolic-androgenic steroids: effects on social behavior and baseline heart rate. | examined the effects of anabolic-androgenic steroids (as) on behavior, baseline heart rate (hr), and stress-induced hr responses. twenty-four cynomolgus monkeys were assigned to four mixed social groups of both as and sham control animals. for 2 months, as-treated monkeys received biweekly injections of testosterone, and, on an identical schedule, the control animals were injected with a sham solution. behavioral data revealed that as disrupted the social milieu such that all dominant animals ex ... | 1990 | 2286185 |
| detection of balantidium coli from evacuated feces in cynomolgus monkeys (macaca fascicularis). | 1990 | 2287142 | |
| effect of testosterone on regulation of the level of sex steroid-binding protein mrna in monkey (macaca fascicularis) liver. | two specific oligonucleotide probes complementary to different regions of human sex steroid-binding protein (sbp) cdna were used to study the levels of hepatic monkey sbp mrna during different hormonal states. in females the sbp mrna level was higher than in males and paralleled the serum sbp level. after castration, the sbp concentration increased in the serum but was reduced after testosterone treatment. in contrast, the hepatic sbp mrna level decreased after castration and was restored by tes ... | 1990 | 2288636 |
| attenuation of the early anterior negativity of median nerve somatosensory evoked potential in the mptp-treated monkey. | median nerve somatosensory evoked potentials (sep) were recorded in 7 cynomolgus monkeys, before and after the administration of n-methyl 1,4 phenyl 1,2,3,6 tetrahydropiridine (mptp), a neurotoxin which induces a parkinsonian syndrome in primates. following mptp administration, the amplitude of the negative component recorded at 15 ms over the frontal derivations (n15) decreased by 70% or more. this amplitude reduction was not modified by administration of dopamine precursors. these findings she ... | 1990 | 2290412 |
| mechanisms of middle ear aeration: anatomic and physiologic evidence in primates. | proper aeration is a prerequisite for normal middle ear function in all terrestrial mammals. our previous studies in primates provided anatomic evidence of neural circuits between the middle ear, brain, and eustachian tube by which central respiratory neurons can control middle ear aeration. yet mechanisms that regulate middle ear aeration remain poorly understood. this study extends our research by examining maturation of these neural circuits, and investigating their underlying physiology. ult ... | 1990 | 2293703 |
| autogenous auricular cartilage implantation following discectomy in the primate temporomandibular joint. | the purpose of this study was to evaluate the histologic changes in primate temporomandibular joints (tmj) treated with autogenous auricular cartilage grafts following total discectomy. four macaca fascicularis monkeys underwent bilateral tmj disc removal and high condylar shaves. one tmj in each monkey was treated by grafting autogenous auricular cartilage to the glenoid fossa; the contralateral joint served as a control. monkeys were killed at 6, 12, 16, and 24 weeks postoperatively. viable au ... | 1990 | 2294210 |
| sensitive periods for lead-induced behavioral impairment (nonspatial discrimination reversal) in monkeys. | a total of 52 nursery-reared monkeys (macaca fascicularis) were dosed orally with 1.5 mg/kg/day of lead on one of four dosing regimens (13 monkeys/group): group 1, vehicle only; group 2, dosed with lead continuously from birth; group 3, dosed with lead from birth to 400 days of age and vehicle thereafter; and group 4, dosed with vehicle from birth to 300 days of age and lead thereafter. this dosing regimen allowed evaluation of differential infant vulnerability as well as reversibility of the be ... | 1990 | 2296763 |
| effects of developmental exposure to methyl mercury on spatial and temporal visual function in monkeys. | detailed characterization of several aspects of visual function was made in two groups of monkeys exposed developmentally to methyl mercury. one group of monkeys (macaca fascicularis) was dosed from birth onward with 50 micrograms/kg/day of mercury as methyl mercury. another group was exposed in utero by dosing the mother with 10, 25, or 50 micrograms/kg/day of mercury as methyl mercury, and postnatally until 4.0-4.5 years of age with the same dose the mother had received. spatial and temporal v ... | 1990 | 2296766 |