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nkt cell adjuvant-based tumor vaccine for treatment of myc oncogene-driven mouse b-cell lymphoma.immunomodulators are effective in controlling hematologic malignancy by initiating or reactivating host antitumor immunity to otherwise poorly immunogenic and immune suppressive cancers. we aimed to boost antitumor immunity in b-cell lymphoma by developing a tumor cell vaccine incorporating α-galactosylceramide (α-galcer) that targets the immune adjuvant properties of nkt cells. in the eμ-myc transgenic mouse model, single therapeutic vaccination of irradiated, α-galcer-loaded autologous tumor c ...201222932803
removal of heavy metal ions from aqueous solution using fe3o4-sio2-poly(1,2-diaminobenzene) core-shell sub-micron particles.in this work, fe(3)o(4)-sio(2)-poly(1,2-diaminobenzene) sub-micron particles (fsps) with high saturated magnetization of ∼60-70 emu/g were developed and utilized for the removal of as(iii), cu(ii), and cr(iii) ions from aqueous solution. the isothermal results fitted well with the freundlich model and the kinetic results fitted well with the two-site pseudo-second-order model, which indicated that multilayer adsorption of as(iii), cu(ii), and cr(iii) ions on fsps occurred at two sites with diffe ...201222939254
composite microspheres for separation of plasmid dna decorated with mnps through in situ growth or interfacial immobilization followed by silica coating.raspberry-like colloidal polymer/magnetite/silica composite microspheres were rationally fabricated based on in situ growth or interfacial immobilization of magnetic nanoparticles (mnps) onto the polymer matrices and the followed sol-gel coating process. monodisperse cross-linked poly(styrene-co-glycidyl methacrylate) microspheres were first prepared by surfactant-free emulsion polymerization, followed by surface modification of carboxyl or amine moieties through thiol-epoxy click chemistry. the ...201222950810
the effect of education on nurses' assessments in an epilepsy monitoring unit.there are few data about the quality of nursing care on an epilepsy monitoring unit. this study evaluated the impact of an educational program on the quality of care provided by nurses in an epilepsy monitoring unit (emu) using an investigator-developed assessment tool.201222953433
fe3o4 nanobelts: one-pot and template-free synthesis, magnetic property, and application for lithium storage.we report on the synthesis of fe(3)o(4) nanobelts with good magnetic properties and lithium storage performances by using a one-pot and template-free hydrothermal method with na(2)co(3) and fecl(2) as the reactants. by controlling the amount of na(2)co(3), we obtained pure fe(3)o(4) nanobelts with widths of 0.1-2 μm, thicknesses of about 10 nm and lengths of 20-30 μm, showing a high aspect ratio. xrd and saed patterns of the obtained sample demonstrated that the fe(3)o(4) nanobelts were well cry ...201222962279
synthesis, growth mechanism and characterization of single crystalline alpha-fe2o3 spherical nanoparticles.in the present report, we proposed a simple and efficient method for synthesizing single crystalline alpha-fe2o3 spherical nanoparticles array into hexagonal dipyramid (hgdp) hierarchical structures using urea as a surface-active agent to control the growth and nucleation of the iron species. growth mechanisms for the formation of hgdp hierarchical structures have been also proposed. single crystalline feature, structural morphology and size of the nanoparticles were investigated by x-ray diffra ...201222962732
wet-chemical green synthesis of l-lysine amino acid stabilized biocompatible iron-oxide magnetic nanoparticles.in this paper, we report a novel method for the synthesis of l-lysine (lys) amino acid coated maghemite (gamma-fe2o3) magnetic nanoparticles (mnps). the facile and cost effective method permitted preparation of the high-quality superparamagnetic gamma-fe2o3 mnps with hydrophilic and biocompatible nature. for this work, first we synthesized magnetite phase fe3o4/lys by wet chemical method and oxidized to y-fe2o3 in controlled oxidizing environment, as evidenced by xrd and vsm magnetometry. the cr ...201222962801
magnetic properties of hydrogen-included tizrnipd quasicrystals.quasicrystals prepared by rapid quenching of pd-added tizrni ingots were hydrogenated, and effects of hydrogen for magnetic properties were compared with the unhydrogenated ones under magnetic fields from -10000 to 10000 oe. the magnetization values obtained from vibrating sample magnetometer (vsm) were analyzed with the combination of powder x-ray diffraction (xrd) data. while its contribution is larger than that of pd, hydrogen decreases the magnetic moments of both pd-doped and undoped quasic ...201222966713
magnetic ionic liquids produced by the dispersion of magnetic nanoparticles in 1-n-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide (bmi.ntf2).̀this paper reports on the advancement of magnetic ionic liquids (mils) as stable dispersions of surface-modified γ-fe(2)o(3), fe(3)o(4), and cofe(2)o(4) magnetic nanoparticles (mnps) in a hydrophobic ionic liquid, 1-n-butyl 3-methylimidazolium bis(trifluoromethanesulfonyl)imide (bmi.ntf(2)). the mnps were obtained via coprecipitation and were characterized using powder x-ray diffraction, transmission electron microscopy, raman spectroscopy and fourier transform near-infrared (ft-nir) spectrosco ...201222966984
synthesis and crystal structure of two synthetic oxofluoride framework compounds--co2teo3f2 and co2seo3f2.two new isostructural co(2+) containing tellurium and selenium oxofluoride compounds co(2)teo(3)f(2) and co(2)seo(3)f(2) are synthesized and their structures determined by single crystal x-ray diffraction. they crystallize in the orthorhombic space group pnma with the unit cell parameters a = 7.3810(5) å, b = 10.1936(7) å, c = 5.3013(3) å and a = 7.2655(8) å, b = 10.0013(13) å, c = 5.3564(6) å, respectively. the co(ii) ion has octahedral coordination [coo(3)f(3)] and builds up a 3d framework by ...201222968840
synthesis of mesoporous magnetic co-nps/carbon nanocomposites and their adsorption property for methyl orange from aqueous solution.mesoporous magnetic co-nps(nanoparticles)/carbon nanocomposites were synthesized by carbonization of polyacrylonitrile (pan) microspheres entrapped with cobalt salt for the first time. the structure and morphology of the porous magnetic nanocomposites were characterized by x-ray diffraction (xrd), transmission electron microscopy (tem), vibrating sample magnetometry (vsm), and n(2) adsorption-desorption technique. the nanocomposites possess very high saturation magnetization (ms is up to ~133 em ...201322975398
multiple nuclear genes and retroposons support vicariance and dispersal of the palaeognaths, and an early cretaceous origin of modern birds.the origin and timing of the diversification of modern birds remains controversial, primarily because phylogenetic relationships are incompletely resolved and uncertainty persists in molecular estimates of lineage ages. here, we present a species tree for the major palaeognath lineages using 27 nuclear genes and 27 archaic retroposon insertions. we show that rheas are sister to the kiwis, emu and cassowaries, and confirm ratite paraphyly because tinamous are sister to moas. divergence dating usi ...201222977150
extending the viability of emu spermatozoa during in vitro storage by manipulation of temperature and diluent potassium concentration.1. survival of emu spermatozoa during in vitro storage is not affected by increasing the extracellular [k(+)] to the point where it does not adversely affect spermatozoa function. 2. in three experiments, the effects were studied of [k(+)] in a diluent in the range 12·5-80 mm/l on emu spermatozoa survival for up to 48 h at 5, 10 or 20°c. 3. at the end of the storage period, spermatozoa viability, motility, fertilising ability and morphology were measured. 4. in experiment 1, spermatozoa viabilit ...201222978589
survival of emu (dromaius novaehollandiae) sperm preserved at subzero temperatures and different cryoprotectant concentrations.three experiments were conducted to optimize the protocol for cryopreservation of emu sperm. ejaculates were collected from trained male emus then diluted 1:1 and pooled before allocation to treatments and measured for sperm viability, motility, egg membrane penetration ability, membrane stability, and morphology. in experiment 1, semen was either cooled to 5 °c after dilution or diluted with a precooled to 5 °c diluent before cooling to 5 °c and then frozen at liquid nitrogen vapor temperatures ...201222980087
a consensus-based approach to patient safety in epilepsy monitoring units: recommendations for preferred practices.patients in an epilepsy monitoring unit (emu) with video-eeg telemetry have a risk for seizure emergencies, injuries and adverse events, which emphasizes the need for strategies to prevent avoidable harm. an expert consensus process was used to establish recommendations for patient safety in emus. workgroups analyzed literature and expert opinion regarding seizure observation, seizure provocation, acute seizures, and activity/environment. a delphi methodology was used to establish consensus for ...201222999858
multifunctional nanoparticles of fe(3)o(4)@sio(2)(fitc)/pah conjugated the recombinant plasmid of pirse2-egfp/vegf(165) with dual functions for gene delivery and cellular imaging.technologies to increase tissue vascularity are critically important to the fields of tissue engineering and cardiovascular medicine. angiogenic factors, like vegf, have been widely investigated to induce vascular endothelial cell proliferation and angiogenesis for establishing a vascular network. however, effective transport of vegf gene to target cells with minimal side effects remains a challenge despite the use of unique viral and non-viral delivery approaches.201223009391
synthesis and cellular compatibility of co-doped zno particles in silk-fibroin peptides.co-doped zno particles were successfully prepared via a facile biomineralization process in the template of silk-fibroin (sf) peptides at room temperature, and sf peptides were coated onto the surface of particles. the ratio of zn/co in reactive solution could substantially influence the morphology of as-prepared particles, and the rough spherical particles including some nanoparticles of 50 nm diameters could be obtained at 4:1 ratio of zn/co. the saturation magnetization of sf-coated co-zno pa ...201323010108
functionalized graphene-coated cobalt nanoparticles for highly efficient surface-assisted laser desorption/ionization mass spectrometry analysis.graphene-coated cobalt nanoparticles surface-functionalized with benzylamine groups (coc-nh(2) nanomagnets) were shown to effectively enrich analytes for surface-assisted laser desorption/ionization mass spectrometry (affinity saldi-ms) analysis. these coc-nh(2) nanomagnets are highly suited for use with affinity saldi-ms because their mean diameter of 30 nm, high specific surface area of 15 m(2) g(-1), and high-strength saturation magnetization of 158 emu g(-1) led to efficient extraction of an ...201223017094
synthesis of multifunctional fluorescent magnetic graphene oxide hybrid materials.fluorescent magnetic graphene oxide hybrid materials have been fabricated by a multistep method. x-ray diffraction, transmission and scanning electron microscopy, fluorescence spectroscopy, fourier transform infrared spectroscopy, vibration sample magnetometry, and energy dispersive spectroscopy were used to characterize the resulting material. the results showed that the materials have a saturation magnetization value of 22.0 emu/g at room temperature and exhibit a symmetrical and narrow emissi ...201223021711
noncoding transcription within the igh distal v(h) region at pair elements affects the 3d structure of the igh locus in pro-b cells.noncoding sense and antisense germ-line transcription within the ig heavy chain locus precedes v(d)j recombination and has been proposed to be associated with igh locus accessibility, although its precise role remains elusive. however, no global analysis of germ-line transcription throughout the igh locus has been done. therefore, we performed directional rna-seq, demonstrating the locations and extent of both sense and antisense transcription throughout the igh locus. surprisingly, the majority ...201223027941
expressional analysis of immunoglobulin d in cattle (bos taurus), a large domesticated ungulate.for decades, it has remained unknown whether artiodactyls, such as cattle, pigs, and sheep, express immunoglobulin d (igd), although the δ gene was identified in these species nearly 10 years ago. by developing a mouse anti-bovine igd heavy chain monoclonal antibody (13c2), we show that secreted bovine igd was present mainly as a monomer in serum and was heavily glycosylated by n-linked saccharides. nonetheless, igd was detectable in some but not all of the holstein cattle examined. membrane-bou ...201223028592
preparation and characterization of monodisperse core-shell fe3o4@sio2 microspheres and its application for magnetic separation of nucleic acids from e. coli bl21.in this article, we present an easy route to prepare monodisperse core-shell fe3o4@sio2 microspheres with uniform size and shape. their structures and properties were studied by transmission electron microscopy (tem), scanning electron microscopy (sem), fourier transform infrared spectrometry (ft-ir), and vibrating sample magnetometer (vsm), respectively. the results showed that spherical fe3o4 microspheres with well dispersion have a rough surface and an average diameter (about 500 nm). after t ...201223030008
safety considerations in the epilepsy monitoring unit for psychogenic nonepileptic seizures.injury occurs in epilepsy monitoring units (emus) to patients with epileptic seizures (es); however, there are limited data regarding the safety concerns of patients with psychogenic nonepileptic seizures (pnes) being monitored in emus. we reviewed emu records from 116 pnes and compared them to 170 es. three falls (2.6%) occurred in pnes without injury compared to 6 falls (3.5%) in es with 1 injury, a facial hematoma. of the 9 total falls, 8 patients were ambulatory during their events. several ...201223032127
concurrent administration of the mmpi-2 and pai in a sample of patients with epileptic or non-epileptic seizures: implications for an inpatient epilepsy monitoring unit.the minnesota multiphasic personality inventory-second edition (mmpi-2) and the personality assessment inventory (pai) are commonly used in the epilepsy monitoring unit (emu) to evaluate personality characteristics and mood-related symptoms in those individuals being evaluated for epileptic seizures (es) or psychogenic non-epileptic seizures (pnes). a direct comparison of these measures through concurrent administration to the same group has not been carried out. both measures were administered ...201223032128
developing a culture of safety in the epilepsy monitoring unit: a retrospective study of safety outcomes.this study retrospectively reviewed 971 consecutive admissions to our epilepsy monitoring unit (emu) from july 2007 to may 2011 to compare falls and missed seizures before and after implementing stricter safety processes in may 2009. new safety processes included enhanced staff education, a falls prevention signed contract with patient/family, observation of video-eeg monitors only by eeg technologists, hourly nurse rounding, standby assistance for hygiene needs, and immediate review of adverse ...201223032129
unexpected dissemination patterns in lymphoma progression revealed by serial imaging within a murine lymph node.non-hodgkin lymphoma (nhl) is a heterogeneous and highly disseminated disease, but the mechanisms of its growth and dissemination are not well understood. using a mouse model of this disease, we used multimodal imaging, including intravital microscopy (ivm) combined with bioluminescence, as a powerful tool to better elucidate nhl progression. we injected enhanced green fluorescent protein and luciferase-expressing eμ-myc/arf(-/-) (cdkn2a(-/-)) mouse lymphoma cells (el-arf(-/-)) into c57bl/6ncrl ...201223033441
selective inhibitors of nuclear export show that crm1/xpo1 is a target in chronic lymphocytic leukemia.the nuclear export protein xpo1 is overexpressed in cancer, leading to the cytoplasmic mislocalization of multiple tumor suppressor proteins. existing xpo1-targeting agents lack selectivity and have been associated with significant toxicity. small molecule selective inhibitors of nuclear export (sines) were designed that specifically inhibit xpo1. genetic experiments and x-ray structures demonstrate that sine covalently bind to a cysteine residue in the cargo-binding groove of xpo1, thereby inhi ...201223034282
compact zwitterion-coated iron oxide nanoparticles for in vitro and in vivo imaging.we have recently developed compact and water-soluble zwitterionic dopamine sulfonate (zds) ligand coated superparamagnetic iron oxide nanoparticles (spions) for use in various biomedical applications. the defining characteristics of zds-coated spions are small hydrodynamic diameters, low non-specific interactions with fetal bovine serum, the opportunity for specific labeling, and stability with respect to time, ph, and salinity. we report here on the magnetic characterization of zds-coated spion ...201323042209
periictal cerebral tissue hypoxemia: a potential marker of sudep risk.cerebral oximetry has not been explored in patients experiencing seizures in the epilepsy monitoring unit (emu). the purpose of our study was to evaluate the feasibility of periictal measurement of cerebral oxygenation using noninvasive cerebral tissue oximetry and to determine whether there was evidence of cerebral hypoxemia during generalized seizures. cerebral oxygen saturation findings were subsequently correlated with sudden unexpected death in epilepsy (sudep) risk factors. we prospectivel ...201223061543
synthesis, crystal structure, and magnetic properties of li3mg2oso6, a geometrically frustrated osmium(v) oxide with an ordered rock salt structure: comparison with isostructural li3mg2ruo6.the novel osmium-based oxide li(3)mg(2)oso(6) was synthesized in polycrystalline form by reducing li(5)oso(6) by osmium metal and osmium(iv) oxide in the presence of stoichiometric amounts of magnesium oxide. the crystal structure was refined using powder x-ray diffraction data in the orthorhombic fddd space group with a = 5.88982(5) å, b = 8.46873(6) å, and c = 17.6825(2) å. this compound is isostructural and isoelectronic with the ruthenium-based system li(3)mg(2)ruo(6). the magnetic ion subla ...201223066706
na(1.515)euges4, a three-dimensional crystalline assembly of empty nanotubules constructed with europium(ii/iii) mixed valence ions.a new compound, na(1.515)euges(4), has been synthesized at 750 °c from a reaction of elemental europium, germanium, and sulfur and na(2)s. the compound crystallizes in the trigonal system with z = 18 and the r3c space group with a = 23.322(3) å, c = 6.838(1) å, and v = 3221.2(9) å(3). na(1.515)euges(4), which is isostructural with na(2)eusise(4), contains quasi-infinite nanoscale (∞)[euges(4)](2-) tubules that are held together by sodium cations through electrostatic interactions. the tubules co ...201223072332
epilepsy care in ontario: an economic analysis of increasing access to epilepsy surgery.in august 2011 a proposed epilepsy care model was presented to the ontario health technology advisory committee (ohtac) by an expert panel on a provincial strategy for epilepsy care in ontario. the expert panel recommended leveraging existing infrastructure in the province to provide enhanced capacity for epilepsy care. the point of entry for epilepsy care and the diagnostic evaluation for surgery candidacy and the epilepsy surgery would occur at regional and district epilepsy centres in london, ...201223074428
phosphotungstic acid anchored to amino-functionalized core-shell magnetic mesoporous silica microspheres: a magnetically recoverable nanocomposite with enhanced photocatalytic activity.h(3)pw(12)o(40) was successfully anchored to the surface of amino-functionalized fe(3)o(4)@sio(2)@meso-sio(2) microspheres by means of chemical bonding to aminosilane groups, aiming to remove unwanted organic compounds from aqueous media. the resultant multifunctional microspheres were thoroughly characterized by transmission electron microscopy, scanning electron microscopy, x-ray diffraction, infrared spectroscopy, inductively coupled plasma, and n(2) adsorption-desorption. the as-prepared mic ...201323083769
water-soluble pd nanoparticles capped with glutathione: synthesis, characterization, and magnetic properties.the synthesis, characterization, and magnetic properties of water-soluble pd nanoparticles capped with glutathione are described. the glutathione-capped pd nanoparticles were synthesized under argon and air atmospheres at room temperature. whereas the former exhibits a bulklike lattice parameter, the lattice parameter of the latter is found to be considerably greater, indicating anomalous lattice expansion. comparative structural and compositional studies of these nanoparticles suggest the prese ...201223092154
psychiatric comorbidity in veterans with psychogenic seizures.psychogenic non-epileptic seizures (pnes) are frequently encountered in epilepsy monitoring units (emu) at veterans affairs medical centers (vamcs) and cause significant long-term disability. an understanding of psychiatric factors associated with pnes could aid in earlier diagnosis and treatment. we studied 50 consecutive veterans diagnosed with pnes and 37 veterans diagnosed with epileptic seizures (es), evaluated at a vamc emu. we reviewed all available mental health evaluations prior to emu ...201223103308
delayed development of chronic lymphocytic leukemia in the absence of macrophage migration inhibitory factor.survival of chronic lymphocytic leukemia (cll) cells depends on stimuli provided by a suitable microenvironment. the factors and mechanisms providing this growth support for cll cells are not fully understood. we found that plasma levels of macrophage migration inhibitory factor (mif), a proinflammatory and immunoregulatory chemokine, were elevated in cll patients. therefore, we characterized the functional role of mif in a cll mouse model. for this purpose, we crossed eμ-tcl1 mice with mif knoc ...201323118218
heparinized magnetic mesoporous silica nanoparticles as multifunctional growth factor delivery carriers.well-defined magnetic mesoporous silica nanoparticles (mmsns) with a core/shell structure were prepared via a one pot synthesis. sphere-like magnetite aggregates were obtained as cores of the final nanoparticles by assembly in the presence of polyvinyl pyrrolidone and cetyltrimethylammonium bromide. the nanoparticles have the property of superparamagnetism with a saturation magnetization value of 20.3 emu g(-1). in addition, the combination of heparin and fluorescence-labeled mmsns endows the re ...201223128185
toca-1 is in a novel pathway that functions in parallel with a sun-kash nuclear envelope bridge to move nuclei in caenorhabditis elegans.moving the nucleus to an intracellular location is critical to many fundamental cell and developmental processes, including cell migration, differentiation, fertilization, and establishment of cellular polarity. bridges of sun and kash proteins span the nuclear envelope and mediate many nuclear positioning events, but other pathways function independently through poorly characterized mechanisms. to identify and characterize novel mechanisms of nuclear migration, we conducted a nonbiased forward ...201323150597
a comparison of the use of urinary cortisol to creatinine ratios and nocturnal salivary cortisol in the evaluation of cyclicity in patients with cushing's syndrome.cyclical cushing's syndrome is detected in our center by collecting sequential early morning urine (emu) samples for cortisol to creatinine ratio over 28 d. the endocrine society suggests that nocturnal salivary cortisol (nsc) may be used to assess patients for cyclical cushing's. however, there is only very limited evidence that it correlates with emu testing or that it demonstrates cycling over 28 d.201323150688
seizure exacerbation in two patients with focal epilepsy following marijuana cessation.while animal models of epilepsy suggest that exogenous cannabinoids may have anticonvulsant properties, scant evidence exists for these compounds' efficacy in humans. here, we report on two patients whose focal epilepsy was nearly controlled through regular outpatient marijuana use. both stopped marijuana upon admission to our epilepsy monitoring unit (emu) and developed a dramatic increase in seizure frequency documented by video-eeg telemetry. these seizures occurred in the absence of other pr ...201223159379
the role of ctcf binding sites in the 3' immunoglobulin heavy chain regulatory region.the immunoglobulin heavy chain locus undergoes a series of dna rearrangements and modifications to achieve the construction and expression of individual antibody heavy chain genes in b cells. these events affect variable regions, through vdj joining and subsequent somatic hypermutation, and constant regions through class switch recombination (csr). levels of igh expression are also regulated during b cell development, resulting in high levels of secreted antibodies from fully differentiated plas ...201223162572
one-pot hydrothermal synthesis of lanthanide ions doped one-dimensional upconversion submicrocrystals and their potential application in vivo ct imaging.multi-functional rare-earth yb(3+) and ln(3+) (ln = er, tm and ho) ions doped one-dimensional (1-d) upconversion submicrocrystals (nayf(4) and nagdf(4)) possessing upconversion luminescence, biocompatibility and magnetic properties have been synthesized by a one-pot hydrothermal method. rare-earth yb(3+) and ln(3+) ions doped nayf(4) microrods (~1 μm in diameter, 3-5 μm in length) exhibit porous properties, and the average pore sizes are ~28.2 nm. they show paramagnetism in the magnetic range of ...201323168841
mir-155 targets histone deacetylase 4 (hdac4) and impairs transcriptional activity of b-cell lymphoma 6 (bcl6) in the eμ-mir-155 transgenic mouse model.multiple studies have established that micrornas (mirnas) are involved in the initiation and progression of cancer. notably, mir-155 is one of the most overexpressed mirnas in several solid and hematological malignancies. ectopic mir-155 expression in mice b cells (eμ-mir-155 transgenic mice) has been shown to induce pre-b-cell proliferation followed by high-grade lymphoma/leukemia. loss of mir-155 in mice resulted in impaired immunity due to defective t-cell-mediated immune response. here we pr ...201223169640
polydopamine-based molecular imprinting on silica-modified magnetic nanoparticles for recognition and separation of bovine hemoglobin.surface molecular imprinting, especially on the surface of silica-modified magnetic nanoparticles, has been proposed as a promising strategy for protein recognition and separation. inspired by the self-polymerization of dopamine, we synthesized a polydopamine-based molecular imprinted film coating on silica-fe(3)o(4) nanoparticles for recognition and separation of bovine hemoglobin (bhb). magnetic molecularly imprinted nanoparticles (about 860 nm) possess a core-shell structure. magnetic molecul ...201323175702
modifying fe3o4 microspheres with rhodamine hydrazide for selective detection and removal of hg2+ ion in water.rhodamine hydrazide modifying fe(3)o(4) microspheres (fe(3)o(4)-r6g) was developed for selective detection and removal of mercury ion from water. with a saturation magnetization of 74.2 emu/g, the fe(3)o(4)-r6g could be simply recollected from water with magnetic separation within a few minutes. the selectivity and adsorption ability of fe(3)o(4)-r6g for metal cations were studied by fluorophotometry and atomic absorption spectrometry, respectively. the results showed that fe(3)o(4)-r6g exhibite ...201323177242
factors associated with failure to follow up with a general practitioner after discharge from the emergency department.to identify factors associated with failure to follow up with a general practitioner (gp) after discharge from the ed or emergency medicine unit (emu).201223216720
facile and straightforward synthesis of superparamagnetic reduced graphene oxide-fe3o4 hybrid composite by a solvothermal reaction.a superparamagnetic reduced graphene oxide-fe(3)o(4) hybrid composite (rgo-fe(3)o(4)) was prepared via a facile and straightforward method through the solvothermal reaction of iron (iii) acetylacetonate (fe(acac)(3)) and graphene oxide (go) in ethylenediamine (eda) and water. by this method, chemical reduction of go as well as the formation of fe(3)o(4) nanoparticles (nps) can be achieved in one step. the fe(3)o(4) nps are firmly deposited on the surfaces of rgo, avoiding their reassembly to gra ...201323220906
preparation and in vitro evaluation of folate-receptor-targeted spion-polymer micelle hybrids for mri contrast enhancement in cancer imaging.polymer-spion hybrids were investigated for receptor-mediated localization in tumour tissue. superparamagnetic iron oxide nanoparticles (spions) prepared by high-temperature decomposition of iron acetylacetonate were monodisperse (9.27 ± 3.37 nm), with high saturation magnetization of 76.8 emu g(-1). amphiphilic copolymers prepared from methyl methacrylate and peg methacrylate by atom transfer radical polymerization were conjugated with folic acid (for folate-receptor specificity). the folate-co ...201323221062
low-temperature hydrothermal synthesis of α-fe/fe3o4 nanocomposite for fast congo red removal.a facile low-temperature hydrothermal process to synthesize α-fe/fe(3)o(4) nanocomposite is reported. tem and hrtem revealed that the α-fe/fe(3)o(4) nanocomposite was composed of catenulate α-fe and lamellar structured fe(3)o(4). the weight ratio of α-fe in the α-fe/fe(3)o(4) nanocomposite is 35.6%. the α-fe/fe(3)o(4) nanocomposite demonstrates an extremely high congo red (cr) removal efficiency from waste water showing almost complete removal within 3 min. for 100 mg l(-1) of cr aqueous solutio ...201323223415
facile synthesis of radial-like macroporous superparamagnetic chitosan spheres with in-situ co-precipitation and gelation of ferro-gels.macroporous chitosan spheres encapsulating superparamagnetic iron oxide nanoparticles were synthesized by a facile and effective one-step fabrication process. ferro-gels containing ferrous cations, ferric cations and chitosan were dropped into a sodium hydroxide solution through a syringe pump. in addition, a sodium hydroxide solution was employed for both gelation (chitosan) and co-precipitation (ferrous cations and ferric cations) of the ferro-gels. the results showed that the in-situ co-preci ...201223226207
efficient lentiviral transduction and transgene expression in primary human b cells.primary human b cells are an attractive target for gene-therapeutic applications, but have been found to be relatively resistant toward transduction with lentiviral vectors (lvvs), even though a number of different envelope pseudotypes were tested. moreover, low transgene expression in primary human b cells has impeded the use of lvvs for this target cell. we investigated the transduction potential of gibbon-ape leukemia virus (galv) env-pseudotyped lvvs for primary human b cells. by establishin ...201223240650
the mtorc1 inhibitor everolimus prevents and treats eμ-myc lymphoma by restoring oncogene-induced senescence.myc deregulation is common in human cancer. ig-myc translocations that are modeled in eμ-myc mice occur in almost all cases of burkitt lymphoma as well as in other b-cell lymphoproliferative disorders. deregulated expression of myc results in increased mtor complex 1 (mtorc1) signaling. as tumors with mtorc1 activation are sensitive to mtorc1 inhibition, we used everolimus, a potent and specific mtorc1 inhibitor, to test the requirement for mtorc1 in the initiation and maintenance of eμ-myc lymp ...201323242809
expressed sequence tag analysis of the emu (dromaius novaehollandiae) pituitary by 454 gs junior pyrosequencing.emus (dromaius novaehollandiae) are farmed for their oil for pharmaceutical and cosmetic uses. this emu pituitary expressed sequence tag study was undertaken to identify novel transcripts in the emu pituitary to propel their identification and functional studies. by mapping reads derived from the roche 454 gs junior pyrosequencer to 8 reference species (human, mouse, chicken, zebra finch, fruit fly, turkey, round worm, and carolina anole lizard) from the unigene database, a total of 81,788 reads ...201323243234
transforming growth factor-β directly induces p53-up-regulated modulator of apoptosis (puma) during the rapid induction of apoptosis in myc-driven b-cell lymphomas.c-myc transformed human burkitt's lymphoma (bl) cells are highly sensitive to tgf-β-induced apoptosis. previously we demonstrated that tgf-β-mediated cell death in bl cells is regulated via the mitochondrial intrinsic apoptosis pathway, which is dependent on the activation of bax and/or bak. tgf-β directly induces transcription of the bh3-only protein bik and represses expression of the pro-survival factor bcl-x(l) but has no effect on the direct bax/bak "activators" bim or bid (tbid). here we s ...201323243310
synthesis of a novel magnetic zeolite nanocomposite for removal of cs+ and sr2+ from aqueous solution: kinetic, equilibrium, and thermodynamic studies.in this study, a novel magnetic zeolite nanocomposite (mznc) was prepared by nanozeolite a and iron oxide. nanocrystalline zeolite a was synthesized, and then, iron oxide nanocrystals were prepared in the presence of nanozeolite. the prepared nanocomposite was characterized by xrd, xrf, ft-ir, dtg, vsm, and tem methods. the applicability of the synthesized nanocomposite for removal of cs(+) and sr(2+) from aqueous solutions was assessed, and the effective parameters such as initial concentration ...201323266030
pressure-dependent enhanced t(c) and magnetic behavior of the metamagnetic and ferromagnetic polymorphs of [fe(iii)cp*2]•+ [tcnq]•- (cp* = pentamethylcyclopentadienide; tcnq = 7,7,8,8-tetracyano-p-quinodimethane).the magnetic behaviors of the metamagnetic and ferromagnetic polymorphs of [fe(iii)cp(2)*](•+)[tcnq](•-) (cp* = pentamethylcyclopentadienide; tcnq = 7,7,8,8-tetracyano-p-quinodimethane) were studied as a function of hydrostatic pressure. both polymorphs exhibit a reversible enhancement of magnetic properties with increasing pressure. the t(c) for the ferromagnetic polymorph increased by 70% from 2.95 to 5.01 k at 10.3 kbar at a rate of 0.21 k/kbar, which is similar to the 0.22 k/kbar reported fo ...201323268738
epigenetic regulator smchd1 functions as a tumor suppressor.smchd1 is an epigenetic modifier of gene expression that is critical to maintain x chromosome inactivation. here, we show in mouse that genetic inactivation of smchd1 accelerates tumorigenesis in male mice. loss of smchd1 in transformed mouse embryonic fibroblasts increased tumor growth upon transplantation into immunodeficient nude mice. in addition, loss of smchd1 in eμ-myc transgenic mice that undergo lymphomagenesis reduced disease latency by 50% relative to control animals. in premalignant ...201223269277
magnetic, fluorescent, and thermo-responsive fe(3)o(4)/rare earth incorporated poly(st-nipam) core-shell colloidal nanoparticles in multimodal optical/magnetic resonance imaging probes.multifunctional colloidal nanoparticles which exhibit fluorescence, superparamagnetism, and thermosensitivity are produced by two step seed emulsifier-free emulsion polymerization in the presence of oleic acid (oa) and sodium undecylenate (naua) modified fe(3)o(4) nanoparticles. in the first step, st and nipam polymerize the naua on the surface of fe(3)o(4) nanoparticles to form fe(3)o(4)/poly(st-nipam) nanoparticles which act as seeds for the polymerization of eu(aa)(3)phen with the remaining s ...201323274069
fast sweep-rate plastic faraday force magnetometer with simultaneous sample temperature measurement.we present a design for a magnetometer capable of operating at temperatures down to 50 mk and magnetic fields up to 15 t with integrated sample temperature measurement. our design is based on the concept of a faraday force magnetometer with a load-sensing variable capacitor. a plastic body allows for fast sweep rates and sample temperature measurement, and the possibility of regulating the initial capacitance simplifies the initial bridge balancing. under moderate gradient fields of ~1 t/m our p ...201223278023
in-situ crystallization route to nanorod-aggregated functional zsm-5 microspheres.herein, we develop a reproducible in situ crystallization route to synthesize uniform functional zsm-5 microspheres composed of aggregated zsm-5 nanorods and well-dispersed uniform fe(3)o(4) nanoparticles (nps). the growth of such unique microspheres undergoes a np-assisted recrystallization process from surface to core. the obtained magnetic zsm-5 microspheres possess a uniform size (6-9 μm), ultrafine uniform fe(3)o(4) nps (~10 nm), good structural stability, high surface area (340 m(2)/g), an ...201323286838
bif-1 haploinsufficiency promotes chromosomal instability and accelerates myc-driven lymphomagenesis via suppression of mitophagy.malignant transformation by oncogenes requires additional genetic/epigenetic changes to overcome enhanced susceptibility to apoptosis. in the present study, we report that bif-1 (sh3glb1), a gene encoding a membrane curvature–driving endophilin protein, is a haploinsufficient tumor suppressor that plays a key role in the prevention of chromosomal instability and suppresses the acquisition of apoptosis resistance during myc-driven lymphomagenesis. although a large portion of bif-1–deficient mice ...201323287860
magnetic fe3o4-graphene composites as targeted drug nanocarriers for ph-activated release.a novel nanocarrier of magnetic fe(3)o(4)-graphene nanocomposites (mgns) was proposed as an effective drug delivery system for cancer treatment. the nanocarrier was synthesized by covalently attaching modified fe(3)o(4) nanoparticles onto water-soluble graphene sheets via the formation of an amide bond with the aid of 1-ethyl-3-(3-dimethyaminopropyl) carbodiimide. the obtained mgns exhibited excellent dispersibility and stability in aqueous solution and they also exhibited superparamagnetic prop ...201323288110
two-in-one strategy for effective enrichment of phosphopeptides using magnetic mesoporous γ-fe₂o₃ nanocrystal clusters.designed with a two-in-one strategy, the magnetic mesoporous γ-fe(2)o(3) nanocrystal clusters (m-γ-fe(2)o(3)) have been successfully prepared for integrating the functions of effective enrichment and quick separation of phosphopeptides into a single architecture. first, the mesoporous fe(3)o(4) nanocrystal clusters (mfe(3)o(4)) were synthesized by solvothermal reaction and then were subjected to calcination in air to form m-γ-fe(2)o(3). the obtained m-γ-fe(2)o(3) have spherical morphology with u ...201323294124
synthesis of novel cocx@c nanoparticles.coc(x) nanoparticles encapsulated in carbon shells were synthesized using a pulsed plasma in liquid ethanol. this is the first time that monolithic cubic phase cobalt carbide nanoparticles have been obtained. x-ray diffraction refinement of the nanoparticles showed that the lattice parameter of prepared cubic phase cobalt carbide is larger than that of coc(x) (44-0962) and cubic phase co (15-0806 and 01-1259). the x-ray absorption fine structure spectra near the co k-edge of the synthesized samp ...201323296080
synthesis of nickel hierarchical structures and evaluation on their magnetic properties and congo red removal ability.novel nickel hierarchical structures were prepared through a facile one-pot solvothermal approach in the presence of surfactant and mineralizer. the influence of dynamics factors such as polyvinylpyrrolidone (pvp) content, ratio (r) between naf and nh(3)·h(2)o on the morphologies of the as-synthesized products were investigated in detail. by regulating the dynamics factors, nickel crystals with three different structures (hcp and fcc mixture structure, fcc structure and a mostly hcp structure) w ...201323299515
functionalization of graphite oxide with magnetic chitosan for the preparation of a nanocomposite dye adsorbent.in the current study, the functionalization of graphite oxide (go) with magnetic chitosan (chm) was investigated to prepare a nanocomposite material (go-chm) for the adsorption of a reactive dye (reactive black 5). the synthesis mechanism was investigated by various techniques (sem/edax, ftir spectroscopy, xrd, xps, dta, dtg, vsm). characterization results indicated that a significant fraction of the amines of the chitosan (i) were inserted between the go layers and (ii) reacted with carboxyl an ...201323301870
opic: ontology-driven patient information capturing system for epilepsy.the widespread use of paper or document-based forms for capturing patient information in various clinical settings, for example in epilepsy centers, is a critical barrier for large-scale, multi-center research studies that require interoperable, consistent, and error-free data collection. this challenge can be addressed by a web-accessible and flexible patient data capture system that is supported by a common terminological system to facilitate data re-usability, sharing, and integration. we pre ...201223304354
epidea: extracting structured epilepsy and seizure information from patient discharge summaries for cohort identification.sudden unexpected death in epilepsy (sudep) is a poorly understood phenomenon. patient cohorts to power statistical studies in sudep need to be drawn from multiple centers due to the low rate of reported sudep incidences. but the current practice of manual chart review of epilepsy monitoring units (emu) patient discharge summaries is time-consuming, tedious, and not scalable for large studies. to address this challenge in the multi-center nih-funded prevention and risk identification of sudep mo ...201223304396
magnetic nanoparticles (mnps) covalently coated by peo-ppo-peo block copolymer for drug delivery.a stable drug carrier has been prepared by covalently coating magnetic nanoparticles (mnps) with peo-ppo-peo block copolymer pluronic p85. the particles were characterized by tem, xrd, dls, vsm, ftir, and tga. a typical product has a 15 nm magnetite core and a 100 nm hydrodynamic diameter with a narrow size distribution and is superparamagnetic with large saturation magnetization (57.102 emu/g) at room temperature. the covalently-coated pluronic-mnps (magpluronics) were proven to be stable in di ...201323305884
atm deficiency augments constitutively nuclear cyclin d1-driven genomic instability and lymphomagenesis.cyclin d1 deregulation is implicated in the genesis of multiple human cancers. importantly, nuclear cyclin d1 retention during s-phase promotes dna re-replication and subsequent genomic instability, providing a direct correlation between aberrant cyclin d1/cdk4 activity, transcriptional regulation and double strand dna break (dsb) induction. together, these molecular events catalyze the genomic instability necessary for neoplastic transformation. given that replication-associated dna damage is c ...201423318439
akt signalling is required for ribosomal rna synthesis and progression of eμ-myc b-cell lymphoma in vivo.the dysregulation of pi3k/akt/mtorc1 signalling and/or hyperactivation of myc are observed in a high proportion of human cancers, and together they form a 'super signalling' network mediating malignancy. a fundamental downstream action of this signalling network is up-regulation of ribosome biogenesis and subsequent alterations in the patterns of translation and increased protein synthesis, which are thought to be critical for akt/myc-driven oncogenesis. we have demonstrated that akt and myc coo ...201323331925
enhanced magnetization in highly crystalline and atomically mixed bcc fe-co nanoalloys prepared by hydrogen reduction of oxide composites.fe(x)co(100-x) nanoalloys (nas) with 20 ≤ x ≤ 80 were prepared by hydrogen reduction of fe-co oxide nano-composites, which were composed of mixed phases (or domains) of fe(2)o(3) and coo. in situ x-ray diffraction (xrd) measurements using synchrotron radiation clearly showed development of a solid-solution fe-co phase by hydrogen reduction from the oxide composites. high-resolution transmission electron microscopy (tem), high-angle annular dark-field scanning tem and powder xrd revealed that fe- ...201323334346
atm-dependent spontaneous regression of early eμ-myc-induced murine b-cell leukemia depends on natural killer and t cells.mechanisms of spontaneous tumor regression have been difficult to characterize in a systematic manner due to their rare occurrence and the lack of model systems. here, we provide evidence that early-stage b cells in eμ-myc mice are tumorigenic and sharply regress in the periphery between 41 and 65 days of age. regression depended on cd4(+), cd8(+), nk1.1(+) cells and the activation of the dna damage response, which has been shown to provide an early barrier against cancer. the dna damage respons ...201323349395
evaluation of novel algorithm embedded in a wearable semg device for seizure detection.we implemented a modified version of a previously published algorithm for detection of generalized tonic-clonic seizures into a prototype wireless surface electromyography (semg) recording device. the method was modified to require minimum computational load, and two parameters were trained on prior semg data recorded with the device. along with the normal semg recording, the device is able to set an alarm whenever the implemented algorithm detects a seizure. these alarms are annotated in the da ...201223366322
bi-functional properties of fe3o4@ypo4:eu hybrid nanoparticles: hyperthermia application.magnetic nanoparticles based hyperthermia therapy is a possible low cost and effective technique for killing cancer tissues in the human body. fe3o4 and fe3o4@ypo4:5eu hybrid magnetic nanoparticles are prepared by co-precipitation method and their average particle sizes are found to be ∼10 and 25 nm, respectively. the particles are spherical, non-agglomerated and highly dispersible in water. the crystallinity of as-prepared ypo4:5eu sample is more than fe3o4@ypo4:5eu hybrid magnetic nanoparticle ...201323370409
inpatient psychiatric consultation for newly-diagnosed patients with psychogenic non-epileptic seizures.to evaluate the prevalence and utilization of inpatient psychiatric consultation (ipc) for patients newly-diagnosed with psychogenic non-epileptic seizures (pness).201323376141
localized dna demethylation at recombination intermediates during immunoglobulin heavy chain gene assembly.multiple epigenetic marks have been proposed to contribute to the regulation of antigen receptor gene assembly via v(d)j recombination. here we provide a comprehensive view of dna methylation at the immunoglobulin heavy chain (igh) gene locus prior to and during v(d)j recombination. dna methylation did not correlate with the histone modification state on unrearranged alleles, indicating that these epigenetic marks were regulated independently. instead, pockets of tissue-specific demethylation we ...201323382652
evaluating midwifery units (emu): lessons from the pilot study.this paper describes the pilot study that was undertaken to test the feasibility of the recruitment plan designed to recruit women who booked to give birth in two freestanding midwifery units in nsw, australia. the pilot preceded the full prospective cohort study, evaluating midwifery units (emu), which aimed to examine the antenatal, birth and postnatal outcomes of women planning to give birth in freestanding midwifery units compared to those booked to give birth in tertiary level maternity uni ...201323395304
sensitisation of c-myc-induced b-lymphoma cells to apoptosis by atf2.transcription factors atf2 (activating transcription factor 2) and atf7 (activating transcription factor 7) are highly homologous members of the activator protein 1 (ap-1) family. their activities are growth factor and stress stimulated and they strictly require phosphorylation by mitogen-activated protein (map) kinases for their transcriptional functions. in samples of human b-cell lymphomas as well as eμ-myc-driven mouse b-cell lymphomas, we find that atf2 as well as map kinase c-jun n-termina ...201423416976
stable aqueous dispersion of superparamagnetic iron oxide nanoparticles protected by charged chitosan derivatives.this article presents the synthesis and characterization of biocompatible superparamagnetic iron oxide nanoparticles (spions) coated with ultrathin layer of anionic derivative of chitosan. the water-based fabrication involved a two-step procedure. in the first step, the nanoparticles were obtained by co-precipitation of ferrous and ferric aqueous salt solutions with ammonia in the presence of cationic derivative of chitosan. in the second step, such prepared materials were subjected to adsorptio ...201323420339
stimuli-responsive magnetic nanoparticles for monoclonal antibody purification.monoclonal antibodies (mabs) are important therapeutic proteins. one of the challenges facing large-scale production of monoclonal antibodies is the capacity bottleneck in downstream processing, which can be circumvented by using magnetic stimuli-responsive polymer nanoparticles. in this work, stimuli-responsive magnetic particles composed of a magnetic poly(methyl methacrylate) core with a poly(n-isopropylacrylamide-co-acrylic acid) (p(nipam-co-aa)) shell cross-linked with n, n'-methylenebisacr ...201323420794
synthesis of one-dimensional fe3o4@c composites from catalytic pyrolysis of waste polypropylene.a simple catalytic pyrolysis route was developed to prepare one-dimensional fe3o4@c composites using waste polypropylene as carbon resource, in which the fe3o4 nanoparticles were self-assembled to necklace-shaped structures. the products were characterized by means of x-ray power diffraction (xrd), raman spectra, field-emission scanning electron microscopy (fesem), and transmission electron microscopy (tem). the results indicate that the diameter of chains is about 550 nm, the size of fe3o4 part ...201223421178
chain length dependence of polyol synthesis of zinc ferrite nanoparticles: why is diethylene glycol so different?superparamagnetic znfe2o4 nanoparticles with size range of 28-38 nm were synthesized by polyol process based on use of varying chain length glycols as solvent. we have offered, for the first time, the plausible mechanism behind in situ formation of zinc ferric oxalate hydroxide hydrate [fe2zn(c2o4)2(oh)3](+)·4h2o complex from diethylene and polyethylene glycol. we are also reporting, the magnetic properties of above complexes. we have found a ferromagnetic ordering in precursor complex compounds ...201323423492
carboxylated sio2-coated α-fe nanoparticles: towards a versatile platform for biomedical applications.carboxylated sio2-coated α-fe nanoparticles have been successfully prepared via cah2-mediated reduction of sio2-coated fe3o4 nanoparticles followed by surface carboxylation. these α-fe-based nanoparticles, which are characterized by ease of coating with additional functional groups, a large magnetization of 154 emu per g-fe, enhanced corrosion resistivity, excellent aqueous dispersibility, and low cytotoxicity, have potential to be a versatile platform in biomedical applications.201323423558
bifunctional graphene/γ-fe₂o₃ hybrid aerogels with double nanocrystalline networks for enzyme immobilization.highly porous hosting materials with conducting (favorable to electron transfer) and magnetic (favorable to product separation) bicontinuous networks should possess great potentials for immobilization of various enzymes in the field of biocatalytic engineering, but the synthesis of such materials is still a great challenge. herein, bifunctional graphene/γ-fe2 o3 hybrid aerogels with quite low density (30-65 mg cm(-3) ), large specific surface area (270-414 m(2) g(-1) ), high electrical conductiv ...201323423944
novel microwave assisted chemical synthesis of nd₂fe₁₄b hard magnetic nanoparticles.the high coercivity and excellent energy product of nd2fe14b hard magnets have led to a large number of high value added industrial applications. chemical synthesis of nd2fe14b nanoparticles is challenging due to the large reduction potential of nd(3+) and the high tendency for nd2fe14b oxidation. we report the novel synthesis of nd2fe14b nanoparticles by a microwave assisted combustion process. the process consisted of nd-fe-b mixed oxide preparation by microwave assisted combustion, followed b ...201323426224
synthesis of multi-core-shell magnetic molecularly imprinted microspheres for rapid recognition of dicofol in tea.magnetic multi-core-shell molecularly imprinted microspheres (fe3o4@mims) based on multi-fe3o4 nanoparticles as core structures and dummy imprinted materials as shell structures have been synthesized by a surface-imprinted technique using dichlorodiphenyltrichloroethane as the dummy template and were successfully used as a specific adsorbent for rapid isolation of trace levels of dicofol from teas. the resulting fe3o4@mims were characterized by scanning electron microscopy, fourier transform inf ...201323432386
the electrocardiogram of anesthetized captive adult emus (dromaius novaehollandiae).to characterize the electrocardiogram (ecg) of anesthetized adult emus (dromaius novaehollandiae).201323434245
fabrication and characterization of a triple functionalization of graphene oxide with fe3o4, folic acid and doxorubicin as dual-targeted drug nanocarrier.a novel triple functionalized drug delivery system was synthesized by encapsulation of superparamagnetic graphene oxide (go) and doxorubicin (dox) with folic acid (fa) conjugated chitosan (chi). the carrier exhibited a high loading efficiency (0.98 mg/mg), a high saturation magnetization (10.5 emu/g) and a prolonged release rate. a real-time monitoring method on the drug release from graphene oxide (go) was reported using dox as the model drug. the release mechanism of dox at different ph was in ...201323434692
rnai screening uncovers dhx9 as a modifier of abt-737 resistance in an eμ-myc/bcl-2 mouse model.abt-737 is a promising chemotherapeutic agent that promotes apoptosis by acting as a selective bh3 mimetic to neutralize bcl-2-like family members. one shortcoming with its use is that mcl-1, a member of the bcl-2 family, is poorly inhibited by abt-737 and thus is a major cause of resistance. we performed a short hairpin rna (shrna)-based drop-out screen to identify novel genes and pathways that could reverse resistance to abt-737 treatment in eµ-myc/bcl-2 lymphoma cells engineered to rely on en ...201323440244
investigation of colloidal stability and insulation characteristics of magnetic oils.superparamagnetic iron-oxide (spio) particles were synthesized by the co-precipitation method and the oleic acid-coated spio (oa-spio) was then obtained by a surface grafting procedure. a stock sample of magnetic oil (mo) with 1.6% particle volume fraction (vf) was obtained by dispersing the oa-spio in insulating naphthenic oil. the mo stock sample was diluted in the same naphthenic oil to yield mo with 0.1, 0.04, 0.02, and 0.01% vf. moreover, the 0.04% vf mo sample was manipulated to yield mo s ...201223447995
structure and paramagnetism in weakly correlated y8co5.we report the basic physical properties of monoclinic y8co5 determined by means of magnetic susceptibility, electrical resistivity, and specific heat measurements. the crystal structure of y8co5 is monoclinic (p2(1)/c) with lattice parameters a = 7.0582(6) å, b = 7.2894(6) å, c = 24.2234(19) å, and β = 102.112(6)° as refined by using synchrotron powder x-ray diffraction data. the compound shows temperature independent paramagnetism with χ0 = 2.1 × 10(-3) emu mol(-1) and sommerfeld parameter γ = ...201323448945
design and development of insulin emulgel formulation for transdermal drug delivery and its evaluation.the objective of the present study was to formulate an insulin emulgel, selection of an optimize formulation through in vitro drug release kinetics and finally evaluate its hypoglycemic activity in animal model. insulin emulgel was prepared using emu oil as penetration enhancer with the combination of carbomer or hydroxypropyl methylcellulose (hpmc) as gelling agent and polysorbate 80 as emulsifier. the response of gelling agent type (carbomer or hpmc) and concentration of other two variables pe ...201323455203
fluorescent magnetic fe3 o4 /rare earth colloidal nanoparticles for dual-modality imaging.fluorescent magnetic colloidal nanoparticles (fmcnps) are produced by a two-step, seed emulsifier-free emulsion polymerization in the presence of oleic acid and sodium undecylenate-modified fe3 o4 nanoparticles (nps). the fe3 o4 /poly(st-co-gma) nanoparticles are first synthesized as the seed and eu(aa)3 phen is copolymerized with the remaining st and gma to form the fluorescent polymer shell in the second step. the uniform core-shell structured fmcnps with a mean diameter of 120 nm exhibit supe ...201323463479
preparation of znfe2o4 nanoparticles in the template of silk-fibroin peptide and their neuro-cytocompability in pc12 cells.there is an urgency to prepare non-neurotoxic nanoparticles (nps) as mri contrast agent. we prepared znfe2o4 nps with monocrystal structure in the template of silk-fibroin (sf) peptide at room temperature. analyses of their crystallite size and nps diameter after the growth of 1 d and 8 d indicated that sf peptide could promote nucleation, growth and dispersion of nps. results of eds, raman and tg proved that there was 4 wt% of the chemical composition of sf in as-prepared nps. a possible growth ...201323466538
uniform magnetic core/shell microspheres functionalized with ni2+-iminodiacetic acid for one step purification and immobilization of his-tagged enzymes.a facile approach has been developed to synthesize fe3o4/pmg (poly (n,n'-methylenebisacrylamide-co-glycidyl methacrylate)) core/shell microspheres using distillation-precipitation polymerization. treating pmg shell with iminodiacetic acid (ida) and ni2+ yields composite microspheres of fe3o4/pmg/ida-ni2+. the ni2+ ions loaded on the surface of microspheres provide abundant docking sites for immobilization of histidine-tagged proteins. the high saturation magnetization of fe3o4/pmg (23 emu/g), de ...201323470159
hematological and serum biochemical profile of farm emus (dromaius novaehollandiae) at the onset of their breeding season.blood profiling is a helpful tool in detecting the health status, metabolic diseases, nutritional deficiencies, and welfare of animals. body weights, body temperatures, hematological and serum biochemical parameters, enzymes, and electrolytes in both sexes of farm emus at the beginning of their breeding season (november in canada), were determined. the reference interval for each analyte was also calculated. emus have lower body temperatures (37.2 ± 0.2) than other poultry species. there was no ...201323472017
in vitro cell imaging using multifunctional small sized kgdf4:yb3+,er3+ upconverting nanoparticles synthesized by a one-pot solvothermal process.multifunctional kgdf4:18%yb(3+),2%er(3+) nanoparticles with upconversion fluorescence and paramagnetism are synthesized. the average sizes of the nanoparticles capped with branched polyethyleneimine (pei) and 6-aminocaproic acid (6aa) are ~14 and ~13 nm, respectively. our kgdf4 host does not exhibit any phase change with the decrease of particle size, which can prevent the detrimental significant decrease in upconversion luminescence caused by this effect observed in the well-known nayf4 host. t ...201323475279
structure, optical, and magnetic properties of (ppn+)2(c70(2-))⋅2 c6h4cl2, which contains dianionic polymeric (c70(2-))n chains.a new salt, (ppn(+))2(c70(2-))⋅2 c6h4cl2 (1), which contains c70(2-) dianions, has been obtained as single crystals (ppn(+) = bis(triphenylphosphine)iminium cation). the c70(2-) dianions form polymeric zigzag (c70(2-))n chains, in which the fullerene units are bonded through single c-c bonds of length 1.581(5)-1.586(6) å. the distance between the centers of neighboring c70(2-) units is 10.441 å. the optical and magnetic properties of (c70(2-))n have also been studied. decreasing the symmetry of ...201323494909
efficient purification of his-tagged protein by superparamagnetic fe3o4/au-anta-co2+ nanoparticles.superparamagnetic fe3o4/au nanoparticles were synthesized and surface modified with mercaptopropionic acid (mpa), followed by conjugating nα,nα-bis(carboxymethyl)-l-lysine hydrate (anta) and subsequently chelating co(2+). the resulting fe3o4/au-anta-co(2+) nanoparticles have an average size of 210 nm in aqueous solution, and a magnetization of 36 emu/g, endowing the magnetic nanoparticles with excellent magnetic responsivity and dispersity. the co(2+) ions in the magnetic nanoparticle shell prov ...201323498223
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