Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| pan-genomic approaches in lactobacillus reuteri as a porcine probiotic: investigation of host adaptation and antipathogenic activity. | after the introduction of a ban on the use of antibiotic growth promoters (agps) for livestock, reuterin-producing lactobacillus reuteri is getting attention as an alternative to agps. in this study, we investigated genetic features of l. reuteri associated with host specificity and antipathogenic effect. we isolated 104 l. reuteri strains from porcine feces, and 16 strains, composed of eight strains exhibiting the higher antipathogenic effect (group hs) and eight strains exhibiting the lower ef ... | 2017 | 28439658 |
| draft genome sequence of lactobacillus reuteri cect8605. | lactobacillus reuteri cect8605 has shown potential probiotic properties in both in vitro and in vivo assays. besides its beneficial characteristics, general aspects concerning genetic stability and safety for human consumption have been studied. its genome sequence has been a useful tool to support preliminary conclusions based on empirical observations. | 2017 | 28473390 |
| lactobacillus paracasei gmnl-32, lactobacillus reuteri gmnl-89 and l. reuteri gmnl-263 ameliorate hepatic injuries in lupus-prone mice. | probiotics are known to regulate host immunity by interacting with systemic and mucosal immune cells as well as intestinal epithelial cells. supplementation with certain probiotics has been reported to be effective against various disorders, including immune-related diseases. however, little is known about the effectiveness of lactobacillus paracasei gmnl-32 (gmnl-32), lactobacillus reuteri gmnl-89 (gmnl-89) and l. reuteri gmnl-263 (gmnl-263) in the management of autoimmune diseases, especially ... | 2017 | 28502277 |
| influence of lactobacillus reuteri l26 biocenol™ on immune response against porcine circovirus type 2 infection in germ-free mice. | probiotic bacteria are frequently used for prevention of bacterial infections of the gastrointestinal tract, but there are only limited studies on their efficacy against viral gut infections in animals. the aim of this study was to investigate the effect of probiotic lactobacillus reuteri l26 biocenol(tm) on the innate and adaptive immune responses in germ-free balb/c mice, experimentally infected by porcine circovirus type 2 (pcv2), which confers immunosuppressive effect. a total of 30 six-week ... | 2017 | 28504566 |
| distinct histone modifications modulate defb1 expression in human vaginal keratinocytes in response to lactobacillus spp. | vaginal commensal lactobacilli are considered to contribute significantly to the control of vaginal microbiota by competing with other microflora for adherence to the vaginal epithelium and by producing antimicrobial compounds. however, the molecular mechanisms of symbiotic prokaryotic-eukaryotic communication in the vaginal ecosystem remain poorly understood. here, we showed that both dna methylation and histone modifications were associated with expression of the defb1 gene, which encodes the ... | 2017 | 28508168 |
| structure of protein emulsion in food impacts intestinal microbiota, caecal luminal content composition and distal intestine characteristics in rats. | few studies have evaluated in vivo the impact of food structure on digestion, absorption of nutrients and on microbiota composition and metabolism. in this study we evaluated in rat the impact of two structures of protein emulsion in food on gut microbiota, luminal content composition, and intestinal characteristics. | 2017 | 28512779 |
| genetically engineered probiotic for the treatment of phenylketonuria (pku); assessment of a novel treatment in vitro and in the pahenu2 mouse model of pku. | phenylketonuria (pku) is a genetic disease characterized by the inability to convert dietary phenylalanine to tyrosine by phenylalanine hydroxylase. given the importance of gut microbes in digestion, a genetically engineered microbe could potentially degrade some ingested phenylalanine from the diet prior to absorption. to test this, a phenylalanine lyase gene from anabaena variabilis (avpal) was codon-optimized and cloned into a shuttle vector for expression in lactobacillus reuteri 100-23c (ph ... | 2017 | 28520731 |
| diabetes-associated microbiota in fa/fa rats is modified by roux-en-y gastric bypass. | roux-en-y gastric bypass (rygb) and duodenal jejunal bypass (djb), two different forms of bariatric surgery, are associated with improved glucose tolerance, but it is not clear whether the gut microbiota contributes to this effect. here we used fa/fa rats as a model of impaired glucose tolerance to investigate whether (i) the microbiota varies between fa/fa and nondiabetic fa/+ rats; (ii) the microbiota of fa/fa rats is affected by rygb and/or djb; and (iii) surgically induced microbiota alterat ... | 2017 | 28524868 |
| polymannuronic acid ameliorated obesity and inflammation associated with a high-fat and high-sucrose diet by modulating the gut microbiome in a murine model. | polymannuronic acid (pm), one of numerous alginates isolated from brown seaweeds, is known to possess antioxidant activities. in this study, we examined its potential role in reducing body weight gain and attenuating inflammation induced by a high-fat and high-sucrose diet (hfd) as well as its effect on modulating the gut microbiome in mice. a 30-d pm treatment significantly reduced the diet-induced body weight gain and blood tag levels (p2·0). pm also had a profound impact on the microbial comp ... | 2017 | 28528593 |
| gut microbiota mediated benefits of barley kernel products on metabolism, gut hormones, and inflammatory markers as affected by co-ingestion of commercially available probiotics: a randomized controlled study in healthy subjects. | barley kernel based products have been shown to induce benefits on blood glucose regulation, cardio-metabolic risk markers and appetite regulating hormones in a time perspective of 11-16 h after intake. the mechanisms have been assigned to gut fermentation of indigestible carbohydrates. the purpose of the present study was to evaluate if the modulatory effects of barley on markers of metabolic- and appetite regulation are affected by a dietary background including a mixture of commercially avail ... | 2016 | 28531784 |
| effects of intravaginal lactic acid bacteria on bovine endometrium: implications in uterine health. | infection and inflammation of the endometrium after calving compromise uterine health, contributing to decreased reproductive efficiency in dairy cows. twenty multiparous cows were distributed in two groups and treated intra-vaginally with a combination of lactic acid bacteria (lab) composed by lactobacillus rhamnosus, pedioccocus acidilactici, and lactobacillus reuteri, or with a sterile carrier (con) twice per week during 3 wk. at the slaughterhouse, vaginal and endometrial swabs were taken fo ... | 2017 | 28532798 |
| structural characterization and evaluation of prebiotic activity of oil palm kernel cake mannanoligosaccharides. | in this study, mannanoligosaccharides (mos) were isolated from palm kernel cake by aqueous extraction using high temperature and pressure. structural characterization of mos was carried out using acid hydrolysis, methylation analysis, esi-ms/ms and 1d/2d nmr. the prebiotic activity of mos was evaluated in vitro using two probiotic lactobacillus strains. sugar analysis indicated the presence of mannose in each of the oligomers. methylation and 1d/2d nmr analysis indicated that the mos have a line ... | 2017 | 28551246 |
| lactobacillus reuteri i5007 modulates intestinal host defense peptide expression in the model of ipec-j2 cells and neonatal piglets. | modulation of the synthesis of endogenous host defense peptides (hdps) by probiotics represents a novel antimicrobial approach for disease control and prevention, particularly against antibiotic-resistant infections in human and animals. however, the extent of hdp modulation by probiotics is species dependent and strain specific. in the present study, the porcine small intestinal epithelial cell line (ipec-j2) cells and neonatal piglets were used as in-vitro and in-vivo models to test whether la ... | 2017 | 28561758 |
| industrial-scale application of lactobacillus reuteri coupled with glycerol as a biopreservation system for inhibiting clostridium tyrobutyricum in semi-hard ewe milk cheese. | the suitability of the biopreservation system formed by reuterin-producing l. reuteri inia p572 and glycerol (required for reuterin production) to prevent late blowing defect (lbd) was evaluated in industrial sized semi-hard ewe milk cheese contaminated with clostridium tyrobutyricum inia 68, a wild strain isolated from a lbd cheese. for this purpose, six batches of cheese were made (three with and three without clostridial spores): control cheeses with lactococci starter, cheeses with l. reuter ... | 2017 | 28576357 |
| erratum to: expression of the clonostachys rosea lactonohydrolase gene by lactobacillus reuteri to increase its zearalenone-removing ability. | 2017 | 28606142 | |
| comparative evaluation of probiotics effects on plasma glucose, lipid, and insulin levels in streptozotocin-induced diabetic rats. | diabetes is a chronic disorder caused by the relative decrease in insulin production from the pancreas, tissue resistance to insulin, or both. daily consumption of probiotics, particularly lactobacilli, has been proposed as a new strategy for prevention or control of diabetes. | 2017 | 28608654 |
| autolyse the cell in order to save it? inducing, then blocking, autolysis as a strategy for delaying cell death in the probiotic lactobacillus reuteri. | to examine whether choline and its derivatives can be used to preserve viable cells of lactobacillus reuteri in autolytic models. | 2017 | 28623443 |
| in vitro activity of probiotic lactobacillus reuteri against gastric cancer progression by downregulation of urokinase plasminogen activator/urokinase plasminogen activator receptor gene expression. | gastric cancer (gc) is the third leading cause of cancer death, and most patients represent metastatic phenotype at the time of diagnosis. urokinase plasminogen activator (upa) system is well known for its critical roles in cancer cells invasion since upa/upa receptor (upar) overexpresses in several cancers. subsequently, suppression of upa/upar gene expression improves patients overall survival and prevents cancer progression. | 2017 | 28643742 |
| detection and physicochemical characterization of membrane vesicles (mvs) of lactobacillus reuteri dsm 17938. | membrane vesicles (mvs) are bilayer structures which bleb from bacteria, and are important in trafficking biomolecules to other bacteria or host cells. there are few data about mvs produced by the gram-positive commensal-derived probiotic lactobacillus reuteri; however, mvs from this species may have potential therapeutic benefit. the aim of this study was to detect and characterize mvs produced from biofilm (bmvs), and planktonic (pmvs) phenotypes of l. reuteri dsm 17938. mvs were analyzed for ... | 2017 | 28659878 |
| efficacy of a standardized extract of matricariae chamomilla l., melissa officinalis l. and tyndallized lactobacillus acidophilus (ha122) in infantile colic: an open randomized controlled trial. | infant colic (ic) is a prevalent physiological event of infants, which can disrupt the child's home environment. we aimed to investigate the effectiveness of a mixture of matricariae chamomilla l., melissa officinalis l. and tyndallized lactobacillus acidophilus (ha122) compared with lactobacillus reuteri dsm 17938 and with simethicone for the treatment of ic. | 2017 | 28665038 |
| gut microbial transformation of the dietary imidazoquinoxaline mutagen meiqx reduces its cytotoxic and mutagenic potency. | the diverse community of microbes present in the human gut has emerged as an important factor for cancer risk, potentially by altering exposure to chemical carcinogens. in the present study, human gut bacteria were tested for their capacity to transform the carcinogenic heterocyclic amine 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (meiqx). eubacterium hallii, lactobacillus reuteri, and lactobacillus rossiae were able to convert meiqx to a new microbial metabolite characterized on the basis of ... | 2017 | 28666384 |
| metabolism of foodborne heterocyclic aromatic amines by lactobacillus reuteri dsm 20016. | the heterocyclic aromatic amine (haa) 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (phip) is converted into 7-hydroxy-5-methyl-3-phenyl-6,7,8,9-tetrahydropyrido[3',2':4,5]imidazo[1,2-a]pyrimidin-5-ium chloride (phip-m1) via a chemical reaction with 3-hydroxypropionaldehyde or acrolein derived from glycerol by reuterin producing gut bacteria. because it is unknown whether this reaction also applies to other haas, seven foodborne haas (2-amino-9h-pyrido[2,3-b]indole (aαc), 3-amino-1,4-dimethyl- ... | 2017 | 28679205 |
| efficacy and safety of probiotic-supplemented triple therapy for eradication of helicobacter pylori in children: a systematic review and network meta-analysis. | the aim of this study was to identify the best probiotic supplementation in triple therapy for pediatric population with helicobacter pylori infection. | 2017 | 28681177 |
| close to the edge: growth restrained by the nad(p)h/atp formation flux ratio. | most fermentative microorganisms grow well-under anaerobic conditions managing a balanced redox and appropriate energy metabolism, but a few species do exist in which cells have to cope with inadequate energy recovery or capture and/or redox balancing. two cases of these species, i.e., the metabolically engineered saccharomyces cerevisiae enabling it to ferment xylose and lactobacillus reuteri fermenting glucose via the phosphoketolase pathway, are here used to introduce a quantification paramet ... | 2017 | 28690597 |
| oral probiotics in the management of gingivitis in diabetic patients: a double blinded randomized controlled study. | diabetic patients are more prone to develop infections such as periodontal diseases. bacteriotherapy with the concept of using good bacterial strains to replace the pathogenic ones emerged as a fascinating field due to the increasing incidence of antibiotic resistance. the aim of this study was to evaluate if a particular combination of probiotics (lactobacillus reuteri dsm 17938 and lactobaciullus reuteri atcc pta 5289) is useful in treating gingivitis in diabetic patients. eighty adult patient ... | 2017 | 28691473 |
| control of lupus nephritis by changes of gut microbiota. | systemic lupus erythematosus, characterized by persistent inflammation, is a complex autoimmune disorder with no known cure. immunosuppressants used in treatment put patients at a higher risk of infections. new knowledge of disease modulators, such as symbiotic bacteria, can enable fine-tuning of parts of the immune system, rather than suppressing it altogether. | 2017 | 28697806 |
| selection of potential probiotic lactobacillus with inhibitory activity against salmonella and fecal coliform bacteria. | three hundred and sixty presumptive lactic acid bacteria (lab) isolated from pregnant sows, newborn, suckling, and weaned piglets were preliminarily screened for anti-salmonella activity. fifty-eight isolates consisting of lactobacillus reuteri (n = 32), lactobacillus salivarius (n = 10), lactobacillus mucosae (n = 8), lactobacillus johnsonii (n = 5), and lactobacillus crispatus (n = 3) were selected and further characterized for probiotic properties including production of antimicrobial substan ... | 2017 | 28712023 |
| lactobacillus reuteri dsm 17938 and a placebo both significantly reduced symptoms in children with functional abdominal pain. | lactobacillus reuteri is a gram-positive bacterium that naturally inhabits the human intestinal tract. this study assessed how effectively the probiotic l. reuteri dsm 17938 managed childhood functional abdominal pain (fap). | 2017 | 28712129 |
| arabinoxylans, inulin and lactobacillus reuteri 1063 repress the adherent-invasive escherichia coli from mucus in a mucosa-comprising gut model. | the microbiota that colonises the intestinal mucus may particularly affect human health given its proximity to the epithelium. for instance, the presence of the adherent-invasive escherichia coli (aiec) in this mucosal microbiota has been correlated with crohn's disease. using short-term screening assays and a novel long-term dynamic gut model, which comprises a simulated mucosal environment (m-shime), we investigated how (potential) pro- and prebiotics may repress colonisation of aiec from mucu ... | 2016 | 28721250 |
| structural characterization of glucosylated lactose derivatives synthesized by the lactobacillus reuteri gtfa and gtf180 glucansucrase enzymes. | glucansucrase enzymes from lactic acid bacteria are receiving strong interest because of their wide range of gluco-oligosaccharide and polysaccharide products from sucrose, some of which have prebiotic potential. glucansucrases gtfa and gtf180 from lactobacillus reuteri strains are known to convert sucrose into α-glucans with different types of linkages, but also to use other molecules as acceptor substrates. here we report that incubation of (n-terminally truncated versions of) these enzymes wi ... | 2017 | 28734224 |
| diacylglycerol kinase synthesized by commensal lactobacillus reuteri diminishes protein kinase c phosphorylation and histamine-mediated signaling in the mammalian intestinal epithelium. | lactobacillus reuteri 6475 (lr) of the human microbiome synthesizes histamine and can suppress inflammation via type 2 histamine receptor (h2r) activation in the mammalian intestine. gut microbes such as lr promote h2r signaling and may suppress h1r proinflammatory signaling pathways in parallel by unknown mechanisms. in this study, we identified a soluble bacterial enzyme known as diacylglycerol kinase (dgk) from lr that is secreted into the extracellular milieu and presumably into the intestin ... | 2017 | 28745328 |
| the effects of lactobacillus reuteri probiotics combined with azithromycin on peri-implantitis: a randomized placebo-controlled study. | the aim of this randomized placebo-controlled clinical study was to investigate the effects of a probiotic tablet containing lactobacillus reuteri in peri-implantitis patients. | 2017 | 28756115 |
| aciduric strains of lactobacillus reuteri and lactobacillus rhamnosus, isolated from human feces, have strong adhesion and aggregation properties. | human feces were streaked onto mrs agar adjusted to ph 2.5, 3.0, and 6.4, respectively, and medium supplemented with 1.0% (w/v) bile salts. two aciduric strains, identified as lactobacillus reuteri hfi-ld5 and lactobacillus rhamnosus hfi-k2 (based on 16s rdna and reca sequences), were non-hemolytic and did not hydrolyze mucin. the surface of lactobacillus reuteri hfi-ld5 cells has a weak negative charge, whereas lactobacillus rhamnosus hfi-k2 has acidic and basic properties, and produces exopoly ... | 2017 | 28756502 |
| next-generation probiotics targeting clostridium difficile through precursor-directed antimicrobial biosynthesis. | integration of antibiotic and probiotic therapy has the potential to lessen the public health burden to antimicrobial-associated diseases. clostridium difficile infection (cdi) represents an important example where rational design of next generation probiotics is being actively pursued to prevent disease recurrence. because intrinsic resistance to clinically relevant cdi antibiotics (vancomycin, metronidazole, and fidaxomicin) is a desired trait in such probiotic species, we screened several bac ... | 2017 | 28760934 |
| lactobacillus reuteri induces gut intraepithelial cd4(+)cd8αα(+) t cells. | the small intestine contains cd4(+)cd8αα(+) double-positive intraepithelial lymphocytes (dp iels), which originate from intestinal cd4(+) t cells through down-regulation of the transcription factor thpok and have regulatory functions. dp iels are absent in germ-free mice, which suggests that their differentiation depends on microbial factors. we found that dp iel numbers in mice varied in different vivaria, correlating with the presence of lactobacillus reuteri this species induced dp iels in ge ... | 2017 | 28775213 |
| supplementation of lactobacilli improves growth, regulates microbiota composition and suppresses skeletal anomalies in juvenile pike-perch (sander lucioperca) reared in recirculating aquaculture system (ras): a pilot study. | this research aimed to test the effects of lactobacilli, applied to cultured pike-perch, either through hydrolyzed otohime fish diet, or through artemia nauplii, on fish growth, microbiota balance and skeletal development. on the 12th day post hatching (dph) fish were divided into following treatment groups: two groups received the combination of otohime and nauplii enriched either with lactobacillus paracasei bghn14+lactobacillus rhamnosus bgt10 or with lactobacillus reuteri bggo6-55+lactobacil ... | 2017 | 28777955 |
| lactobacillus caviae sp. nov., an obligately heterofermentative bacterium isolated from the oral cavity of a guinea pig (cavia aperea f. porcellus). | a gram-stain-positive, facultatively anaerobic, and catalase- and oxidase-negative bacterial strain designated mozm2t, having 98.4 % 16s rrna gene sequence identity with lactobacillus reuteri dsm 20016t, was isolated from a swab of the oral cavity of a home-bred guinea pig. comparative analyses based on the hsp60, phes and tuf genes confirmed l. reuteri as its closest relative species, with calculated sequence similarities of 92.8, 88.8 and 96.9 %, respectively. dna-dna hybridisation revealed a ... | 2017 | 28820096 |
| efficacy of lactobacillus reuteri dsm 17938 for the treatment of acute gastroenteritis in children: protocol of a randomized controlled trial. | acute gastroenteritis (age) is one of the most common diseases among children. oral rehydration therapy is the key treatment. however, despite proven efficacy, it remains underused. this is because oral rehydration solution neither reduces the frequency of bowel movements and fluid loss nor shortens the duration of illness. hence, there is interest in adjunctive treatments. according to the 2014 guidelines developed by the european society for paediatric gastroenterology, hepatology and nutritio ... | 2017 | 28835355 |
| mining novel starch-converting glycoside hydrolase 70 enzymes from the nestlé culture collection genome database: the lactobacillus reuteri ncc 2613 gtfb. | the glycoside hydrolase (gh) family 70 originally was established for glucansucrases of lactic acid bacteria (lab) converting sucrose into α-glucan polymers. in recent years we have identified 3 subfamilies of gh70 enzymes (designated gtfb, gtfc and gtfd) as 4,6-α-glucanotransferases, cleaving (α1 → 4)-linkages in maltodextrins/starch and synthesizing new (α1 → 6)-linkages. in this work, 106 putative gtfbs were identified in the nestlé culture collection genome database with ~2700 genomes, and t ... | 2017 | 28855510 |
| to add or not to add probiotics to infant formulae? an updated systematic review. | we updated evidence on the effects of the administration of probiotic-supplemented infant formulae (if) compared with unsupplemented if. five databases were searched up to september 2016 for randomised controlled trials. twenty publications were identified, including five new rcts. supplementation of if with bifidobacterium lactis bb12, either alone or with streptococcus thermophilus, had no effect on growth, respiratory illness, antibiotic use, stool frequency or consistency. however, there was ... | 2017 | 28856907 |
| probiotic supplementation in preterm: feeding intolerance and hospital cost. | we hypothesized that giving the probiotic strain lactobacillus reuteri (l. reuteri) dsm 17938 to preterm, formula-fed infants would prevent an early traumatic intestinal inflammatory insult modulating intestinal cytokine profile and reducing the onset of feeding intolerance. newborn were randomly allocated during the first 48 h of life to receive either daily probiotic (10⁸ colony forming units (cfus) of l. reuteri dsm 17938) or placebo for one month. all the newborns underwent to gastric ultras ... | 2017 | 28858247 |