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survey of veterinary professionals for antibodies to bartonella henselae in japan.the seroprevalence of bartonella henselae among veterinary professionals in japan was investigated by means of an immunoperoxidase (ip) test that used protein a-horseradish peroxidase conjugate. sera were obtained from 233 veterinary professionals in the tokyo and chiba areas. as negative control group, sera from 155 healthy individuals (all medical students) were used. as positive control group, sera from 5 patients highly suspected of cat scratch disease (csd) by clinical symptoms were tested. ...200111685779
chronic active myocarditis following acute bartonella henselae infection (cat scratch disease).an association between bartonella infection and myocardial inflammation has not been previously reported. we document a case of a healthy young man who developed chronic active myocarditis after infection with bartonella henselae (cat scratch disease). he progressed to severe heart failure and underwent orthotopic heart transplantation. bartonella henselae, therefore, should be included among the list of infectious agents associated with chronic active myocarditis.200111688584
enzyme immunoassay for the diagnosis of cat-scratch disease defined by polymerase chain reaction.whole-cell immunofluorescent antibody (ifa) tests for detection of anti-bartonella henselae immunoglobulin (ig) g are commonly used to diagnose cat-scratch disease (csd). the need to cultivate b. henselae in vero cells for antigen preparation and the absence of routinely applied ifa assays for igm constitute the major disadvantages of this form of test. we describe the results of an enzyme immunoassay (eia) for igm and igg that used n-lauroyl-sarcosine-insoluble outer membrane antigens from agar ...200111692296
sudden cardiac death in swedish orienteers--a mystery solved? 200111696208
experimental infection and horizontal transmission of bartonella henselae in domestic cats.in order to study b. henselae transmission among cats, five young cats were kept in confinement for two years, one of them being inoculated by sc route with b. henselae (10(5) ufc). only occasional contact among cats occurred but the presence of fleas was observed in all animals throughout the period. blood culture for isolation of bacteria, pcr-hsp and ftsz (gender specific), and bh-pcr (species-specific), as well as indirect immunofluorescence method for anti-b. henselae antibodies were perfor ...200111696847
culture negative endocarditis combined with glomerulonephritis caused by bartonella species in two immunocompetent adults.two cases of culture negative endocarditis are presented. in both, bartonella species could be identified as the causative agent and in one of them bartonella henselae was very likely. both cases were accompanied by glomerulonephritis, in one case proven by a kidney biopsy. a nephrotic syndrome may be the first presentation of an endocarditis caused by bartonella species.200111705641
[unusual manifestations of bartonella infections].the authors review the cases of two patients with an atypical form of cat scratch disease. the first case exhibited ileocoecal and hepatoportal lymphadenitis, and the second case the emerging symptoms of a non-specific granulomatous process in the middle third of the right forearm, which caused a differential-diagnostic problem. establishment of a diagnosis was possible only on the basis of the disease process and the pathological, serological and histopathological pictures of the lymphatic glan ...200111706512
[acute generalized cat scratch disease in myelodysplastic syndrome].in patients with normal immunity, cat scratch disease typically develop a papule at the portal of entry and no other cutaneous features. a 73 year old male patient with a myelodysplastic syndrome developed generalized petechial, papular and, vasculitic skin lesions in association with cat scratch disease. after the diagnosis was established by identifying the causative organism in a lymph node biopsy, the patient was treated with erythromycin for three weeks resulting in progressive clearance of ...200111715399
bartonella spp antibodies and dna in aqueous humour of cats.bartonella spp antibodies were measured in the serum and aqueous humour of cats with and without uveitis and polymerase chain reaction (pcr) for bartonella spp dna was performed on aqueous humour from most of the cats. serum and aqueous humour were assayed from 49 client-owned cats with uveitis, 49 healthy shelter cats, and nine cats experimentally inoculated with either b henselae or b clarridgeiae, 454 days after inoculation. an aqueous antibody coefficient (c value) was calculated for cats po ...200011716593
molecular characterization of first human bartonella strain isolated in italy.the aim of this study was to characterize a bartonella strain (ba-1) isolated from a blood culture of an italian, human immunodeficiency virus-positive patient with bacillary angiomatosis. we analyzed the isolate using molecular biology methods such as whole-cell fatty acid analysis, pcr-restriction fragment length polymorphism analysis, type-specific 16s rrna pcrs, sequence analysis of the 16s rrna, pulsed-field gel electrophoresis, and arbitrarily primed pcr. the ba-1 isolate turned out to be ...200111724882
immunopathology of bartonella vinsonii (berkhoffii) in experimentally infected dogs.following natural infection with bartonella, dogs and humans develop comparable disease manifestations including endocarditis, peliosis hepatis, and granulomatous disease. as the immunologic response to infection in these hosts has not been clearly established, data presented here was derived from the experimental infection of six specific pathogen free (spf) beagles with a known pathogenic strain of bartonella. six dogs were inoculated intravenously with 10(9)cfu of b. vinsonii ssp. berkhoffii ...200111730925
cat scratch disease due to bartonella henselae infection mimicking parotid malignancy.an unusual bartonella henselae infection presenting clinically as a putative parotid cancer was diagnosed based on serological tests, histomorphology and amplification of a 16s-rdna sequence of bartonella henselae. the patient improved greatly upon antibiotic treatment and did not require surgery. although uncommon, infection with bartonella spp., particularly bartonella henselae, should be included in the differential diagnosis of parotid tumors.200111757975
histological evidence of disease in wild stoats (mustela erminea) in england.forty-four free-living stoats were collected from five game estates in england and examined for evidence of disease. all the macroscopic lesions were attributable to the trauma associated with being trapped or shot. there were no significant microscopic lesions in 27 (61 per cent) of the stoats. there was evidence of nematode parasitism in the intestines of six stoats (14 per cent), and in the lungs of five stoats (11 per cent), and of pulmonary granulomatous inflammation or microgranulomas in f ...200111765324
natural history of bartonella infections (an exception to koch's postulate). 200211777823
cat scratch disease (bartonellosis) mimicking an sle flare.only recently bartonella species have been recognized as important human pathogens. cat scratch disease (csd), caused by infection with bartonella henselae, shows a steady increase in the number of cases throughout the world. we report a case of an 18-year-old woman with systemic lupus erythematosus (sle) who presented with ongoing fever, arthralgias and loss of weight which did not respond to increasing doses of corticosteroids. after exclusion of common infections a photograph of her cat in co ...200111787880
role of bartonella henselae in the etiology of henoch-schönlein purpura.the etiology of henoch-schönlein purpura (hsp) has been ascribed to a variety of infectious and noninfectious agents. because we encountered a patient with hsp who had evidence of bartonella henselae infection and a prior report of a patient with systemic cat-scratch disease presenting as leukoclastic vasculitis, we investigated the association of b. henselae infection with hsp.200211791094
prevalence of bartonella species and 16s rrna gene types of bartonella henselae from domestic cats in thailand.prevalence of bartonella infection among 275 cats in 9 sites from 4 geographical regions (northern area: chiang mai; central area: kanchanaburi, ratchaburi, and bangkok; northeastern area: khon kaen, roi et, ubon ratcharthani, and nakhonratchasima; southern area: songkhla) of thailand was investigated. overall, bartonella species were isolated from 27.6% (76 of 275) of the cats. the isolation rate varied from 12.8% (5 of 39) in songkhla (southern area) to 50.0% (26 of 52) in khon kaen (northeast ...200111791975
evidence of rodent-associated bartonella and rickettsia infections among intravenous drug users from central and east harlem, new york city.we tested serum samples collected in 1997 and 1998 from a cohort of 204 injection drug users (idus) recruited from central and east harlem, new york city, new york, for antibodies reactive with seven rickettsial or bartonella spp. antigens. rodent-associated bartonella elizabethae and rickettsia akari were the primary etiologic agents of interest. the testing panel also included bartonella henselae, bartonella quintana, rickettsia prowazekii, rickettsia rickettsii, and rickettsia typhi. the high ...200111791987
arthropod-transmitted infectious diseases of cats. 200111795958
granuloma annulare: another manifestation of bartonella infection?granuloma annulare (ga) is a common cutaneous eruption whose pathogenesis remains unknown. recent literature has suggested a relation between borrelia infection and ga, a relation that has not been widely accepted. earlier works attempted unsuccessfully to implicate various other infectious agents. some reports have demonstrated the increased frequency of ga in patients with human immunodeficiency virus infection, again raising the possibility of an infectious etiology. using polymerase chain re ...200111801791
aortic valve endocarditis caused by bartonella henselae: a rare surgical entity.we report a case of aortic valve endocarditis caused by bartonella henselae. the patient initially presented to a regional hospital with generalized symptoms including lethargy, malaise and decreased appetite. transthoracic echocardiogram revealed a large vegetation on the aortic valve and he was treated empirically with broad spectrum intravenous antibiotics. several blood cultures were obtained which all returned negative results and the white blood cell count was normal. he was transferred to ...200111803150
visceral leishmaniasis in a new york foxhound kennel.although endemic throughout much of the world, autochthonous visceral leishmaniasis has been reported on only 3 previous occasions in north america. after diagnosis of visceral leishmaniasis in 4 foxhounds from a kennel in dutchess county, new york (index kennel), serum and ethylenediamine-tetraacetic acid (edta)-anticoagulated blood were collected from the remaining 108 american or cross-bred foxhounds in the index kennel and from 30 beagles and basset hounds that were periodically housed in th ...200211822802
rheumatic manifestations of bartonella infection in 2 children.we describe 2 patients with very unusual rheumatological presentations presumably caused by bartonella infection: one had myositis of proximal thigh muscles bilaterally, and the other had arthritis and skin nodules. both patients had very high levels of antibody to bartonella that decreased in association with clinical improvement. bartonella infection should be considered in the differential diagnosis of unusual myositis or arthritis in children.200211824958
the interactions of bartonella with endothelial cells and erythrocytes. 200111825706
experimental infection of domestic cats with bartonella koehlerae and comparison of protein and dna profiles with those of other bartonella species infecting felines.bartonella koehlerae, a recently described feline bartonella species, was isolated from two naturally infected cats in northern california. we experimentally infected domestic cats with b. koehlerae to establish the microbiological and immunological characteristics of this infection in cats and to compare it to infections with those caused by b. henselae and b. clarridgeiae. four cats were inoculated intradermally with b. koehlerae (8.6 x 10(7) to 3.84 x 10(8) cfu/ml). none of the cats presented ...200211825958
treatment and prevention of infective endocarditis.the paper presents the most recent recommendations for the treatment and prevention of infective endocarditis (ie). the treatment of ie is complex and requires close collaboration among specialists in infectious diseases, cardiology, cardiac surgery and microbiology. the mainstay of medical treatment is antibiotic therapy. theoretical considerations regarding vegetations and antibiotics have practical consequences on the route and modalities of administration of antibiotics and on the techniques ...200211829727
deformin, a substance found in bartonella bacilliformis culture supernatants, is a small, hydrophobic molecule with an affinity for albumin.culture supernatants of bartonella bacilliformis were previously shown to contain a factor, called deforming factor or deformin, which causes deformation and invagination of red cell membranes and formation of intracellular vacuoles. this factor is here shown to be a small water-soluble molecule, approximately 1400 da as estimated by gel-filtration chromatography. deforming factor binds tightly to albumin, especially albumin dimers and multimers, present in the growth medium. it can be released ...200111831868
[new and emerging rickettsial and bartonella infections].there have been recently reports on over 10 new and resurgent rickettsioses and bartonelloses in different countries, which reflects both socioeconomic processes in society and a higher methodological level of indication and identification of causative agents. in 1991, the author' laboratory, n. f. gamaleya research institute of experimental medicine, russian academy of medical sciences, established the etiology of the new rickettsiosis astrakhan spotted fever. it separated and studied 2 strains ...200111837209
phylogenetic classification of bartonella species by comparing groel sequences.bartonella is a bacterial genus classified in the alpha-proteobacteria on the basis of 165 rdna sequence comparison. the highly conserved heat-shock chaperonin protein, groel, has proved to be a valuable resolving tool to classify ten bartonella species. the groel gene was amplified and sequenced from ten bartonella isolates: bartonella alsatica, bartonella vinsonii subsp. arupensis, bartonella taylorii, bartonella tribocorum, bartonella birtlesii, bartonella henselae marseille (urlly8), b. hens ...200211837299
autoimmune haemolytic anaemia triggered by bartonella henselae infection: a case report.bartonella henselae is a hitherto unidentified cause of autoimmune haemolytic anaemia. here we report a case of coombs-negative autoimmune haemolytic anaemia. the episode was preceded by exposure to a cat and a non-specific infectious syndrome. concomitant serum titres of b. henselae antibodies were indicative of a recent infection. the case report suggests that b. henselae infection can trigger secondary autoimmune haemolytic anaemia.200111843827
rapid allelic discrimination from real-time dna amplification.a rapid method based on fluorescence resonance energy transfer and real-time polymerase chain reaction (pcr) is used to identify the factor v genotype or to identify the bacterial species bartonella qunitana or bartonella henselae. allelic discrimination was performed on the post-pcr product. thermal cyclers other than the 7700 sequence detection system can be used for pcr, after which the products can be transferred to the 7700 sequence detection system for measurement of fluorescence. the delt ...200111846614
detection of bartonella henselae and bartonella quintana by a simple and rapid procedure using broad-range pcr amplification and direct single-strand sequencing of part of the 16s rrna gene.objective: to detect directly bartonella henselae and bartonella quintana using culture-independent, molecular techniques, and to evaluate a simple and rapid procedure that allows uncultivable bacteria to be detected in usually sterile clinical specimens in a diagnostic laboratory. methods: from four clinical specimens proven to contain b. henselae (n=3) or b. quintana (n=1) dna, part of the 16s rrna gene was amplified using the polymerase chain reaction (pcr) and broad-range bacterial primers f ...199711864111
human infection with bartonella species. 199711864213
endocarditis in a dutch patient caused by bartonella quintana. 199711864215
bartonella (rochalimaea) quintana endocarditis in an algerian farmer. 199611866779
bartonella henselae infection mimicking a splenic lymphoma.we report a bartonella henselae infection in a 40-y-old patient who presented with fever, weight loss, night sweats, elevated lactate dehydrogenase and multinodular splenomegaly with multiple abdominal lymphadenopathies. splenic cat-scratch disease is an exceptional diagnosis in adults and can easily be mistaken for a splenic lymphoma, thereby leading to an unnecessary splenectomy.200111868771
infections in the homeless.homeless people in developed countries have specific problems predisposing them to infectious diseases. respiratory infections and outbreaks of tuberculosis and other aerosol transmitted infections have been reported. homeless intravenous drug users are at an increased risk of contracting hiv, and hepatitis b and c infections. skin problems are the main reason the homeless seek medical attention, and these commonly include scabies, pediculosis, tinea infections, and impetigo. many foot disorders ...200111871479
cervical cat scratch disease lymphadenitis in a patient with immunoglobulin m antibodies to toxoplasma gondii.we report on a young patient with chronic cervical lymphadenopathy and serological and histological evidence for infection with bartonella henselae and toxoplasma gondii. serological follow-up studies, including testing for avidity of toxoplasma-specific immunoglobulin g antibodies, assisted in the determination of the cause of the acute lymphadenitis. our results suggest that the clinical symptoms were most likely due to cat scratch disease rather than to acute toxoplasmosis.200211874902
pyomyositis associated with bacillary angiomatosis in a patient with hiv infection.bacillary angiomatosis is an opportunistic infection occurring predominantly in patients with hiv infection. the manifestations of this vasculoproliferative disorder vary markedly. virtually any organ site may be involved, singly or multiply. however cutaneous involvement can be a valuable clue to its diagnosis. we report a case of bacillary angiomatosis in an hiv-infected patient presenting as isolated pyomyositis of the right leg. the rarity of such a presentation and paucity of cutaneous lesi ...200211876519
genomic variation of bartonella henselae strains detected in lymph nodes of patients with cat scratch disease.bartonella henselae is the primary agent of cat scratch disease (csd). in order to study the genetic variation of b. henselae and the correlation of the various genotypes with epidemiological and clinical findings, two seminested, groel- and pap31-based pcr assays were carried out with specimens from 273 patients. amplicons were sequenced to determine the genotype of the causative bartonella species. compared to our reference intergenic spacer region-based pcr, the groel- and pap31-based assays ...200211880432
[adult, afebrile patient with rapidly growing tumor of the upper arm: bartonella henselae as the etiology]. 200211885017
cat-scratch disease in an immunocompromised host.the main causative agents of cat-scratch disease are bartonella henselae, tiny, gram-negative bacilli. the disease usually has a benign course with the development of a papule at the inoculation site, followed by regional lymphadenopathy. in most cases, complete resolution occurs, but in immunocompromised hosts, the course of the disease can be aggravated.200211887039
bacterial persistence within erythrocytes: a unique pathogenic strategy of bartonella spp.the genus bartonella comprises human-specific and zoonotic pathogens responsible for a wide range of clinical manifestations, including carrion's disease, trench fever, cat scratch disease, bacillary angiomatosis and peliosis, endocarditis and bacteremia. these arthropod-borne pathogens typically parasitise erythrocytes in their mammalian reservoir host(s), resulting in a long-lasting haemotropic infection. we have studied the process of bartonella erythrocyte parasitism by tracking green fluore ...200211890558
prosthetic valve endocarditis caused by bartonella quintana.we describe the first case of bartonella quintana endocarditis affecting a prosthetic valve in a person with no known risk factors for this infection. bartonella should be considered as a cause of endocarditis in any clinical setting.200211897074
bartonella-associated endothelial proliferation depends on inhibition of apoptosis.bartonella is a gram-negative pathogen that is unique among bacteria in being able to induce angioproliferative lesions. cultured human endothelial cells have provided an in vitro system in which to study the basis of angioproliferation. previous studies have attributed the organism's ability to induce angioproliferative lesions to direct mitotic stimulation of endothelial cells by these bacteria. here we show that bartonella inhibits apoptosis of endothelial cells in vitro, and that its ability ...200211904386
[a case of cat scratch disease with encephalopathy].we report an atypical case of cat scratch disease (csd), accompanied with encephalopathy that is a rare complication of csd. a 17-year old man consulted a doctor for his right axillary lymphadenopathy. the history of his contact with cats and the sign of lymphnode swelling and fever suggested a suspect of cat scratch disease. administration of ampicillin improved his clinical symptoms, but a few days later he suddenly fell into coma after an episode of convulsion. the ct scan of the brain and la ...200211904996
pyogenic granuloma: pyogenic again? association between pyogenic granuloma and bartonella.pyogenic granulomas (pg) are benign vascular lesions which were thought to have an infectious etiology, yet none has been found. bacillary angiomatosis (ba), which presents as disseminated vascular lesions in immunosuppressed patients, and verruga peruana (vp), which presents as crops of vascular nodules in immunocompetent persons, are caused by infection with bartonella. thus, the question was raised whether bartonella could be associated with the development of pg, also a vasoproliferative les ...200111907853
bacterial secrets of secretion: euroconference on the biology of type iv secretion processes.type iv secretion systems (tfss) mediate secretion or direct cell-to-cell transfer of virulence factors (proteins or protein-dna complexes) from many gram-negative animal, human and plant pathogens, such as agrobacterium tumefaciens, bartonella tribocorum, bordetella pertussis, brucella suis, helicobacter pylori, legionella pneumophila and rickettsia prowazekii, into eukaryotic cells. bacterial conjugation is also classified as a tfss-like process mediating the spread of broad-host-range plasmid ...200211918819
vegetative endocarditis in six cats.between 1990 and 1997 vegetative endocarditis was diagnosed in six neutered cats (three males, three females) aged between 3 and 9 years. two cats were purebred (one persian and one tonkinese), the remaining four being domestic short haired cats. the diagnosis was made using echocardiography (five cases) or at necropsy (one case). concurrent involvement of the aortic and mitral valve was noted in four cats, the aortic valve alone was affected in one case, and the tricuspid valve in another. a li ...199911919032
cat-scratch disease in children--texas, september 2000-august 2001.cat-scratch disease (csd), a bacterial infection caused by bartonella henselae, has emerged as a relatively common and occasionally serious zoonotic disease among children and adults. to illustrate the spectrum of clinical manifestations of csd observed during a 1-year period, texas children's hospital (tch) in houston reviewed the medical records of 32 children evaluated at tch during september 2000-august 2001 whose antibody titers indicated recent bartonella infection. this report summarizes ...200211922191
skin microflora and bacterial infections of the skin.the skin is a milieu for controlled bacterial growth. skin supports the growth of commensal bacteria, which protect the host from pathogenic bacteria. environmental and local factors, host immunity, and organism adherence and virulence are intricately related to cutaneous infection. resident gram-positive bacteria include staphylococcus, micrococcus, and corynebacterium sp. staphylococcus aureus and streptococcus pyogenes are notoriously pathogenic in the skin. in order for bacteria to be pathog ...200111924823
a case report of bacillary angiomatosis in a patient infected with human immunodeficiency virus.a man infected with human immunodeficiency virus (hiv) presented with a few-month history of an enlarging friable growth on the medial area of the left foot and a one-week history of bilateral lower extremity edema. clinical and histologic examination led to a diagnosis of bacillary angiomatosis, and the patient responded to antibiotic therapy we provide an overview of bacillary angiomatosis, a rare disorder that affects immunocompromised patients with cd4 cell counts less than 100/microl.200211926335
bartonella bovis bermond et al. sp. nov. and bartonella capreoli sp. nov., isolated from european ruminants.two novel species of bartonella isolated from european ruminants are described. bartonella capreoli sp. nov. was isolated from the blood of roe-deer (capreolus capreolus) captured in chizé, france. the type strain is ibs 193t (= cip 106691t = ccug 43827t). it is distinct from another european ruminant isolate that originated from a cow from a french herd of 430 dairy cattle. the latter isolate belongs to a novel species named bartonella bovis bermond et al. sp. nov. the type strain is strain 91- ...200211931146
severe thrombocytopenic purpura as a complication of cat scratch disease. 200211931328
prevalence of bartonella infection in domestic cats in denmark.whole blood and serum from 93 cats (44 pets and 49 shelter/stray cats) from denmark were tested for the presence of feline bartonella species by culture and for the presence of bartonella antibodies by serology. bartonella henselae was isolated from 21 (22.6%) cats. bacteremia prevalence was not statistically different between shelter/stray cats (13/49, 26.5%) and pet cats (8/44, 18.2%), but varied widely by geographical origin of the cats, even after stratification for cat origin or age (p < 0. ...200211944808
a heat-stable component of bartonella henselae upregulates intercellular adhesion molecule-1 expression on vascular endothelial cells.bartonella henselae upregulated the expression of intercellular adhesion molecule-1 (icam-1) on human umbilical vein endothelial cells (huvecs). the induction level of icam-1 depended on the inoculation bacterial dose. icam-1 expression began increasing 4 h after infection and reached a sustained peak beginning at 12 h after b. henselae infection; this time course was similar to that of lipopolysaccharide (lps) of escherichia coli. the stimulatory effect was abolished when live b. henselae were ...200211967118
cat-scratch disease in children--texas, september 2000 to august 2001. 200211974428
the global phylogeny of glycolytic enzymes.genes encoding the glycolytic enzymes of the facultative endocellular parasite bartonella henselae have been analyzed phylogenetically within a very large cohort of homologues from bacteria and eukaryotes. we focus on this relative of rickettsia prowazekii along with homologues from other alpha-proteobacteria to determine whether there have been systematic transfers of glycolytic genes from the presumed alpha-proteobacterial ancestor of the mitochondrion to the nucleus of the early eukaryote. th ...200211983902
subgingival microbiota of brazilian subjects with untreated chronic periodontitis.different periodontopathogenic microbiota have been associated with periodontal diseases in several populations. the present investigation determined the subgingival microbiota of untreated chronic periodontitis brazilians using the checkerboard dna-dna hybridization technique.200211990436
in situ detection of bartonella henselae cells.a new in situ hybridization technique was developed for identification of bartonella henselae cells in cell suspension or in tissue sections. use of highly specific probes labeled with either fluorescein or digoxigenin allows discrimination between b. henselae and closely related b. quintana cells. no cross-hybridization with other bartonella or non-bartonella species was observed. besides its specificity it showed higher sensitivity as compared to pcr based detection methods. moreover, its appl ...200212005447
cat scratch disease. 200212016189
isolation of bartonella henselae from domestic cats in an italian urban area.bartonella henselae is the causative agent of cat scratch disease (csd) in humans. cat is considered the reservoir of the bacterium. identification of bacteriemic cats is the basic tool in the prophylaxis of csd. blood samples were collected between january 1999-december 2000 from 248 domestic cats living in an urban area (reggio emilia) in northern italy and tested for bartonella henselae bacteriemia. cultural and pcr methods were used. pcr was used directly on cat blood as well as to identify ...200212019735
inoculation with bartonella henselae followed by feline herpesvirus 1 fails to activate ocular toxoplasmosis in chronically infected cats.infection by toxoplasma gondii is very common in cats although most remain disease free. the factors that trigger development of uveitis in some cats infected with t gondii have not been elucidated, but infection by more than one organism may be contributory. in this study, cats chronically infected with t gondii were inoculated with bartonella henselae followed by fhv-1 to test the hypothesis that immune stimulation by multiple infections will reactivate ocular toxoplasmosis. anterior uveitis a ...200212027509
prevalence of antibodies to bartonella henselae, b. elizabethae and b. quintana in swedish domestic cats.sera from 292 cats were analyzed by means of indirect immunofluorescence for antibodies to bartonella henselae, b. quintana and b. elizabethae. the sera were sent to the swedish national institute of veterinary medicine for health monitoring and were tested retrospectively for antibodies to bartonella. the most prevalent antibodies (25%) reacted with the b. elizabethae antigen. cats with such antibodies were older than those without antibodies. the prevalence of antibodies to b. elizabethae was ...200212030392
from the centers for disease control and prevention. cat-scratch disease in children--texas, september 2000-august 2001. 200212035788
genotypic characteristics of two serotypes of bartonella henselae.the study of 16s rrna gene sequences of all isolates of bartonella henselae obtained in our laboratory and others from human patients or cats has revealed two genotypes according to the sequence of the 16s rrna gene. two isolates of these genotypes have previously been related to two different serotypes, and lack of cross-protection of the two serotypes has been demonstrated in cats. we investigated the grouping of eight strains of b. henselae on the basis of 16s ribosomal dna, 35-kda protein, p ...200212037055
lacrimal gland involvement in kikuchi-fujimoto disease.purpose. a 32-year-old saudi female presented with typical kikuchi-fujimoto disease, i.e., fever, cervical lymphadenitis and leukopenia, but there was also painful upper eyelid swelling with pain on upgaze. methods. a connective tissue disease and lymphoma workup were unremarkable, as were antibody titers to apifia felis and bartonella henselae. results. orbital computed tomography showed significant lacrimal gland enlargement. cervical node biopsy revealed necrotizing lymphadenitis. conclusion. ...199812048711
fatal meningitis and encephalitis due to bartonella henselae bacteria.bacterial infection due to bartonella henselae commonly develops in children and young adults following cat/dog contacts and/or cat/dog scratches. regional lymphadenopathy is its most common clinical expression. however, encephalitis and parinaud's syndrome (oculoglandular syndrome) have also been reported as has systemic illness. a review of the international literature in all languages revealed no fatal complications in immunocompetent hosts. a four-year-old white child with no underlying illn ...200212051353
detection of bartonella quintana from body lice (anoplura: pediculidae) infesting homeless people in tokyo by molecular technique.we report detection of bartonella quintana brenner, the pathogenic agent of trench fever, from body lice, pediculus humanus l., infesting homeless people in tokyo by polymerase chain reaction. two of 12 (16.7%) homeless were infested with bartonella-positive body lice. from the current status of the recent increase of homeless people in many large cities of the developed countries, a medical examination of homeless people should be carefully performed in the consideration of trench fever. sampli ...200212061434
low prevalence of bartonella henselae infections in norwegian domestic and feral cats.bartonella henselae is the causative agent of cat scratch disease (csd). this clinical entity is very rarely encountered in human medical practice in norway. b. henselae infections including bacteraemia in cats have been frequently reported. the objective of the present study was to investigate the seroprevalence rate and the degree of b. henselae bacteraemia in norwegian domestic and feral cats. one hundred cats investigated at a small animal veterinary practice in the middle of norway were inc ...200212076266
[treatment of bite wounds and cat-scratch disease].although rabies is the most serious consequence of animal bite injuries, in urban rabies-free countries the risk of rabies is far lower than the risk of bacterial infections of the wound. the most frequent etiologic cause of the wound infections after dog bites is pasteurella multocida, as well as in the case of bites by cats, after which cat-scratch disease may also develop, its main cause being bartonella henselae. all bite injuries must be carefully cleaned and disinfected; it is necessary to ...200112078126
guidelines for preventing opportunistic infections among hiv-infected persons--2002. recommendations of the u.s. public health service and the infectious diseases society of america.in 1995, the u.s. public health service (usphs) and the infectious diseases society of america (idsa) developed guidelines for preventing opportunistic infections (ois) among persons infected with human immunodeficiency virus (hiv); these guidelines were updated in 1997 and 1999. this fourth edition of the guidelines, made available on the internet in 2001, is intended for clinicians and other health-care providers who care for hiv-infected persons. the goal of these guidelines is to provide evi ...200212081007
lack of correlation between bartonella dna detection within fleas, serological results, and results of blood culture in a bartonella-infected stray cat population.to correlate the presence of different bartonella species in the blood of a stray cat population trapped on a french military base with specific antibodies and species detected in cat fleas.200212084102
gross hematuria in a young child with axillary lymphadenopathy. 200212086202
do plant and human pathogens have a common pathogenicity strategy?recently, a novel 'two-step' model of pathogenicity has been described that suggests host-cell-derived vasculoproliferative factors play a crucial role in the pathogenesis of bacillary angiomatosis, a disease caused by the human pathogenic bacterium bartonella henselae. the resulting proliferation of endothelial cells could be interpreted as bacterial pathogens triggering the promotion of their own habitat: the host cell. similar disease mechanisms are well known in the plant pathogen agrobacter ...200212088662
how bacteria could cause cancer: one step at a time.helicobacter pylori highlighted the potential for bacteria to cause cancer. it is becoming clear that chronic infection with other bacteria, notably salmonella typhi, can also facilitate tumour development. infections caused by several bacteria (e.g. bartonella spp., lawsonia intracellularis and citrobacter rodentium) can induce cellular proliferation that can be reversed by antibiotic treatment. other chronic bacterial infections have the effect of blocking apoptosis. however, the underlying ce ...200212088666
[bartonella infection].bartonella species have been recently recognized as an important human pathogen associated with a wide spectrum of diseases. four members of the genus are known to cause human infection: bartonella baciliformis, b. henselae, b. quintana and b. elizabethae. b. baciliformis, the first identified bartonella species, is the agent of two disease entities, oroya fever and verruga peruana., b. henselae and b. quintana are two species involved in producing bacteremic syndromes (relapsing fever, trench f ...200112092178
diagnostic methods current best practices and guidelines for identification of difficult-to-culture pathogens in infective endocarditis.culture-negative endocarditis currently represents a diagnostic challenge for physicians. traditional methods such as histology, serology, and culture have been improved and new molecular techniques have been developed to improve the detection of difficult-to-culture agents. serologic tests for the two most frequent etiologic agents, coxiella burnetii and bartonella spp, should be performed first because they can usually be identified easily in this way. the sensitivity of culture for intracellu ...200212092478
value of microimmunofluorescence for diagnosis and follow-up of bartonella endocarditis.bartonella endocarditis is a disease of emerging importance that causes serious complications and high rates of mortality. due to the fastidious nature of bartonella species and their high degrees of antibiotic susceptibility, cultures of clinical samples most often remain sterile and valvular biopsy specimens, the best specimens for pcr amplification, are seldom available. therefore, serology appears to be the easiest diagnostic tool. in order to determine the best cutoff value for serology and ...200212093675
induction of a potential paracrine angiogenic loop between human thp-1 macrophages and human microvascular endothelial cells during bartonella henselae infection.bartonella henselae is responsible for various disease syndromes that loosely correlate with the immune status of the host. in the immunocompromised individual, b. henselae-induced angiogenesis, or bacillary angiomatosis, is characterized by vascular proliferative lesions similar to those in kaposi's sarcoma. we hypothesize that b. henselae-mediated interaction with immune cells, namely, macrophages, induces potential angiogenic growth factors and cytokines which contribute in a paracrine manner ...200212117969
positive polymerase chain reaction and histology with borderline serology in parinaud's oculoglandular syndrome.to report a case of parinaud's oculoglandular syndrome (pos) in which, despite a borderline serology, polymerase chain reaction (pcr) testing for a conjunctival biopsy was positive for bartonella henselae, a source of cat-scratch disease. a steiner silver stain demonstrated the organism.200212131048
bacillary splenitis (bartonella henselae) during immune restoration in an hiv-infected patient. 200212131223
bartonella quintana in human erythrocytes.bartonella quintana is transmitted by body lice among homeless people. infection with this organism leads to chronic bacteraemia with few symptoms. we looked for b quintana in erythrocytes in a population of homeless people in marseille, france. in this report we show the intraerythrocytic presence of b quintana in people with symptomless bacteraemia, by use of a specific monoclonal antibody and laser confocal microscopy. presence of at least 5 x 10(4) colony-forming units per ml was predictive ...200212133660
characterization of the first bartonella henselae strain isolated from a cat in italy.bartonella henselae has been identified and characterized for the first time in italy. a strain, designed pavia-1, was isolated from the blood of a cat whose owner developed cat scratch disease (csd). pavia-1 and two american b. henselae strains (houston-1, atcc 49882, type i and strain 269608, uc davis, type ii) were compared by whole-cell fatty analysis (cfa), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (sds-page) for protein profiles, western immunoblotting (wb) for reactivity w ...200212135236
investigation of bartonella infection in ixodid ticks from california.a total of 1253 ixodid ticks (254 tick pools) collected between the end of 1995 and the spring of 1997 from six california counties (el dorado, los angeles, orange, santa cruz, shasta and sonoma) were examined for the presence of bartonella dna by pcr of the citrate synthase gene. of 1,119 adult ixodes pacificus ticks tested, 26 (11.6%) of 224 pools, each containing five ticks, were positive (minimum percentage of ticks harboring detectable bartonella dna, 2.3%). bartonella pcr-positive ticks we ...200212135237
fourteen-year seroepidemiological study of zoonoses in a greek village.a seroepidemiological study carried out in a high-risk village in crete in 1985-1987 and 1998 showed that although the awareness of the people concerning zoonoses had increased during this period, the situation did not improve: there was a significant increase of the spread of seroprevalence in time and space of coxiella burnetii, rickettsia typhi, brucella sp., and entamoeba histolytica. toxoplasma gondii, rickettsia conorii, borrelia burgdorferi, echinococcus granulosus, leishmania sp., and fa ...200212135274
serological investigation of bartonella henselae infections in clinically cat-scratch disease-suspected patients, patients with cardiovascular diseases, and healthy veterinary students in japan.seroprevalence of bartonella henselae was investigated in japan in 48 individuals clinically suspected of having cat-scratch disease (csd), 159 patients with cardiovascular diseases, and 129 healthy veterinary students. of 48 csd-suspected patients examined, 19 (39.6%) were positive for b. henselae-igg and 4 (8.3%) for b. henselae-igm. of 159 patients with cardiovascular diseases, 5 (3.1%) were positive for b. henselae-igg. in healthy veterinary students, 14 of 129 (10.9%) were positive for b. h ...200212139390
[bacillary angiomatosis].bacillary angiomatosis is a bacterial disease which affects mainly immunosuppressed patients. it may compromise any tissue, especially the skin, presenting papules, nodules or angiomatous tumors. we studied three young men with aids, all of them with 1-2 papules, nodules or subcutaneous tumors suggesting telangiectatic granuloma, sarcoma and lipoma. microscopically, they were misdiagnosed as telangiectatic granuloma, kaposi's sarcoma and "angioma with secondary inflammation". after reviewing the ...200212152480
unilateral neuroretinitis and periparillary serous retinal detachment in cat-scratch disease.cat-scratch disease is a self-limited infection characterized by subacute regional lymphadenitis, which is usually preceded by a history of being scratched by a cat infected with the bartonella species. neuroretinitis, retinochoroiditis, isolated papillitis and peripapillary angiomatosis are features of posterior segment involvement. however, vision loss is very rare. we report a patient with cat-scratch disease associated with unilateral neuroretinitis and peripapillary serous retinal detachmen ...200212162517
acute disseminated encephalomyelitis in children.to describe the epidemiologic, clinical, neuroimaging, and laboratory features; treatment; and outcome in a cohort of children with acute disseminated encephalomyelitis (adem).200212165620
a new type iv secretion system promotes conjugal transfer in agrobacterium tumefaciens.two dna transfer systems encoded by the tumor-inducing (ti) plasmid have been previously identified in agrobacterium tumefaciens. the virb operon is required for the transfer of transferred dna to the plant host, and the trb system encodes functions required for the conjugal transfer of the ti plasmid between cells of agrobacterium. recent availability of the genome sequence of agrobacterium allowed us to identify a third system that is most similar to the virb type iv secretion system of barton ...200212169609
cat scratch disease. survey on the presence of bartonella henselae among cats of tuscany.to verify the presence of bartonella henselae-infection in cats living in tuscany (central italy) serological and bacteriological surveys were carried out. the blood serum samples of 427 cats, 254 living in private houses and gardens and 173 in public or private catteries, were tested for anti-b. henselae antibodies by indirect immunofluorescence assay (ifa). among these samples, 35 were examined by ifa to detect antibodies against bartonella quintana. bacteriological examinations were performed ...200212173772
ultrastructural changes in a standard strain of bartonella henselae after passages through balb/can mice.human bartonelloses are a group of illnesses of poorly understood pathogenesis. bartonella henselae is one of the most studied bacterium of its genus. the objective of this study was to observe whether passages of these bacteria, in vivo, would determine ultrastructural changes in them. for this purpose, isogenic mice were inoculated with a standard strain of b. henselae (i). these were initially retrieved from genetically immunodeficient animals (ii) and then inoculated in immunocompetent ones. ...200212184374
an uncommon presentation of bartonella-associated neuroretinitis.this article documents a case of neuroretinitis initially presenting with ocular pain, 20/20 visual acuities, optic disc edema, and macular serous detachment without macular star formation in the absence of a history of exposure to pets or cats or symptoms suggestive of bartonella infection. this initial clinical presentation appeared unilateral, but later became bilateral.200212199539
genetic and ecologic characteristics of bartonella communities in rodents in southern china.ecologic and bacteriologic observations of small mammals captured in yunnan province in the people's republic of china indicated that bartonella infections occurred at a high prevalence among some rodent species. sequence analyses of the citrate synthase genes of these bartonella demonstrated that rodents in this region harbored a diverse assemblage of strains. the bartonella isolates obtained from apodemus, eothenomys, and rattus typically clustered separately by genus of rodent host. cultures ...200212201602
role of cat-scratch disease in lymphadenopathy in the head and neck.bartonella henselae is the causative agent of cat-scratch disease (csd), which usually manifests as acute regional lymphadenopathy. the causes of cervical lymphadenopathy, with special regard to csd, were investigated in a study of 454 patients who presented with unclear masses in the head and neck from january 1997 through january 2001. sixty-one patients (13.4%) experienced csd; 54 (11.9%) had primary lymphadenopathy due to other infectious agents, and 41 (9.0%) had lymphadenopathy that occurr ...200212203159
bartonella quintana bacteremia among homeless people.bartonella quintana infections have recently reemerged, predominantly among the homeless populations in cities in both europe and the united states. b. quintana can cause trench fever, endocarditis, and chronic bacteremia; the human body louse is the only known vector. homeless people who presented to the emergency departments of university hospital in marseilles, france, were studied, as were those who had been admitted to other medical facilities in the city since 1 january 1997. samples of bl ...200212203165
comparison of in-house and commercial slides for detection by immunofluorescence of immunoglobulins g and m against bartonella henselae and bartonella quintana.we compared the sensitivities and specificities of indirect fluorescent antibody tests developed in our laboratory and commercially available from focus technologies (ft; formerly mrl diagnostic) for detection of serum antibodies to bartonella spp. serum samples tested were from patients with culture- or pcr-confirmed bartonella quintana or b. henselae infections causing cat scratch disease (csd), chronic bacteremia, or endocarditis. at a cutoff titer of 64, the ft test had higher sensitivity th ...200212204950
skin manifestations of bartonella infections. 200212207759
bacillary angiomatosis of the anterior orbit, eyelid, and conjunctiva.to report a case of bacillary angiomatosis of the lower eyelid, conjunctiva, and anterior orbit.200212208256
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