Publications

avian cholera and waterfowl biology.		1992	1474673
molecular analysis of the aroa gene of pasteurella multocida and vaccine potential of a constructed aroa mutant.	the aroa gene from pasteurella multocida was cloned by complementation of the escherichia coli aroa mutant ab2829 with a dna library constructed in puc18. the nucleotide sequence of the p. multocida aroa gene indicated an open reading frame encoding a protein of 441 amino acids, which showed a high degree of homology with the amino acid sequences of various other bacterial aroa proteins. the cloned p. multocida aroa gene was inactivated by insertion of a kanamycin-resistance gene and reintroduce ...	1992	1474900
some aspects of the epidemiology and control of salmonella typhimurium infection in outwintered suckler cows.	two outbreaks of salmonella typhimurium infections affected outwintered, spring-calving suckler cows in late pregnancy. the infections spread rapidly both within and between groups of stock on the affected farms, with morbidity in the infected groups varying from 14.5 per cent to over 60 per cent, and mortality in adult cattle varying from 0 to 14.3 per cent. prophylactic measures included the use of antibiotics and killed vaccines against escherichia coli, salmonella dublin, s typhimurium, and ...	1992	1475896
the 1991 enzyme engineering award--alexander m. klibanov.		2000	1476364
interaction between bordetella bronchiseptica and toxigenic pasteurella multocida on the nasal mucosa of spf piglets.	the interaction between bordetella bronchiseptica and type d toxigenic pasteurella multocida was studied in five groups of 4 specific-pathogen-free (spf) piglets each. at 28 days of age, piglets of groups 3 and 4 were inoculated into both nostrils with 10(8) colony-forming-units (cfu) of a non-dermonecrotic toxin (dnt)-producing, phase i strain of b. bronchiseptica. piglets of groups 1 and 3 were treated intranasally with a sonic extract of the non-toxic strain of b. bronchiseptica and those of ...	1992	1477161
the first outbreak of fowl cholera in muscovy ducks (cairina moschata) in japan.	the first outbreak of fowl cholera occurred in a flock of muscovy ducks (cairina moschata) in okinawa prefecture of japan in november 1990. fifty (25%) of 200 birds in a farm died of an acute disease. remaining birds recovered after treatment with oxytetracycline. pasteurella multocida subsp. multocida was isolated in pure culture from all tissues tested from two dead birds. serovars of the isolates were identified as carter's capsular type a. heddleston's type 3.4.12, and namioka's type 5:a whi ...	1992	1477178
pharmacokinetic evaluation of ceftiofur in serum, tissue chamber fluid and bronchial secretions from healthy beef-bred calves.	ceftiofur is a new broad spectrum cephalosporin marketed for the treatment of acute bovine respiratory disease. in this investigation ceftiofur was administered by intramuscular injection, at 24 h intervals, to healthy beef-bred calves for four days at dosages of 2.2 and 4.4 mg/kg of body weight, with 4 wk intervals between dosing regimens. serum, tissue chamber fluid (tcf), and bronchial secretion (bs) concentrations of ceftiofur were measured by microbiological assay after the first and fourth ...	1992	1477795
[pathological and clinical study of the primary b and t cell lymphomas of intestines].	thirty-one cases of primary non-hodgkin's lymphoma of intestine were typed with monoclonal antibodies uchl1, ki-b5, l26 and ki-mip. among them, there were 21 b cell lymphomas and 10 t cell lymphomas. morphologically, the low-grade malt lymphomas consisted of centrocyte-like cells, accompanying frequently with lymphoepithelial lesions and residual germinal centers, whereas the t cell lymphomas consisted of pleomorphic lymphoma cells, always accompanying with vascular infiltration, massive necrosi ...	2006	1477934
interictal hm-pao spect: a routine investigation in patients with medically intractable complex partial seizures?	single photon emission computed tomography (spect) is increasingly being used as an adjunctive technique in the localisation of epileptogenic foci prior to surgery. as yet, few studies have been undertaken to establish the clinical associations of areas of reduced cerebral perfusion. sixty-three consecutive patients (15 male, 48 female; median age 30 years, range 14-57 years) with medically intractable complex partial seizures (median/month 8, range 1-36) were investigated as outpatients. all ha ...	2006	1478200
factors affecting the strength of flexor tendon repair.	the effects of different thicknesses and configurations of core sutures were studied in human cadaveric flexor tendon repairs. both straight and cyclic load tests were employed. to exploit the full strength of 4/0 suture material, the kessler repair using four locked single knots would seem to be appropriate.	1992	1479249
[occurrence and drug resistance of bacteria pathogenic to the lungs from autopsy material of swine].	eight hundred and fifty-four piglets which died or were euthanized due to pneumonia or rhinitis atrophicans, were investigated during the period of 1986-1990. of the animals, 569 showed bronchopneumonia, 218 had pleuritis, pericarditis and peritonitis, 165 had rhinitis atrophicans, 58 pleuropneumonia, and 9 animals had fibrinous pneumonia. pasteurella multocida, haemophilus parasuis, bordetella bronchiseptica, actinobacillus pleuropneumoniae and pasteurella haemolytica were isolated in 59.1%, 29 ...	1992	1481214
representation of clinical data using snomed iii and conceptual graphs.	none of the coding schemes currently contained within the unified medical language system (umls) is sufficiently expressive to represent medical progress notes adequately. some coding schemes suffer from domain incompleteness, others suffer from the inability to represent modifiers and time references, and some suffer from both problems. the recently released version of the systematized nomenclature of medicine (snomed iii) is a potential solution to the data-representation problem because it is ...	2006	1482897
the process and outcome of a collaborative effort to design and implement a clinician order processing system.		2006	1482980
vaccination of turkeys with cell-free culture filtrate of pasteurella multocida: effects of dilution, iron chelation, and heterologous challenge.	two experiments were done to further define cell-free culture filtrate (ccf) from pasteurella multocida and its endotoxin content in protecting turkeys against challenge. in the first experiment, the greater-than-30,000-molecular-weight fraction of p. multocida strain r44/6 (serotype 3/4/9/12) ccf was used in 10-fold dilutions given by air-sac inoculation or aerosol to vaccinate turkeys, which were subsequently challenged with either homologous (p-1059, serotype 3) or heterologous (x-73, serotyp ...	1992	1485881
turkey macrophage and heterophil bactericidal activity against pasteurella multocida.	bactericidal activity of turkey macrophages and heterophils was demonstrated in an in vitro colorimetric bactericidal assay. two vaccine strains and one field isolate of pasteurella multocida a:3,4 and a single isolate each of escherichia coli and staphylococcus aureus were compared for susceptibility to the bactericidal activity of turkey macrophages and heterophils. only p. multocida a:3,4-strain m-9 (the least virulent strain) was susceptible to macrophage bactericidal activity in the absence ...	1992	1485882
characteristics of pasteurella multocida isolated from humans, swine and poultry in thailand.	pasteurella multocida is a pathogen of animals and humans. most of the patients have been associated with animals but many cases had not contacted them. the failure to diagnose p. multocida infections is mostly due to misidentification on gram stained smears and inadequate laboratory identification techniques. in order to compile detailed characteristics of the organism we studied the physical and biochemical properties of 70 isolates of p. multocida - 17 human, 23 swine and 30 poultry. all isol ...	1992	1488711
avoidance of endotoxin-induced inflammation during studies of albumin clearance from caprine joints.	intra-articular injection of radiolabelled, commercial goat serum albumin (gsa) produces acute arthritis in caprine joints. this inflammation distorts clearance values and vitiates studies of normal lymphatic function. endotoxin, routinely found in commercial albumin preparations, appears to cause this local reaction. we describe a simple method for the preparation of low-endotoxin, radioiodinated serum albumin from aseptically collected serum. we have used this technique to prepare gsa for use ...	1992	1489542
[practice replaced by theory].		2006	1489591
quality assurance. count, compare and change.		2006	1489696
chronic solar urticaria initially provoked by an ultraviolet a solarium.		2006	1489717
transduction and biological psychiatry.		2006	1489759
[oligoarthritis and bursitis caused by pasteurella multocida secondary to a cat scratch].		1992	1489806
polymyxin b: pharmacokinetics of single doses given intravenously and intramuscularly to turkeys, and minimal inhibitory concentrations for escherichia coli and pasteurella multocida.	the 50% and 90% minimal inhibitory concentrations (mic50 and mic90) of polymyxin b for avian escherichia coli and pasteurella multocida isolates were determined by the agar plate dilution method. polymyxin b at approximate mic level in serum was bactericidal for e. coli in 2 to 4 hours. aqueous polymyxin b sulfate was administered by a single bolus intravenous injection into turkeys at 10,000 iu/kg, and by a single bolus intramuscular injection at 5,000, 10,000 or 20,000 iu/kg. effective serum d ...	1992	1492521
evaluation of an atrophic rhinitis vaccine under controlled conditions.	a vaccine containing inactivated cultures of bordetella bronchiseptica, toxigenic pasteurella multocida type d and dermonecrotic p multocida type d toxoid in an oil-in-water adjuvant was given to seven sows, with seven others acting as controls. half the piglets in each litter were exposed intranasally when four days old to b bronchiseptica and when eight days old to toxigenic p multocida type d. there was considerably less sneezing in the litters of the vaccinated sows and when the piglets were ...	1992	1496755
factors affecting endotoxin release from the cell surface of avian strains of pasteurella multocida.	two avian strains of pasteurella multocida, a vaccine strain and a virulent field isolate, were investigated to determine their propensity to release endotoxin from the cell surface. both organisms released comparable amounts of endotoxin when plasma complement proteins were present, however the virulent strain did so without the loss of viability that occurred in the vaccine strain. blocking complement activity decreased the ability of plasma to elicit endotoxin release from the bacteria. when ...	1992	1496810
passive protection of mice with antiserum to neuraminidase from pasteurella multocida serotype a:3.	antiserum to a partially purified neuraminidase from pasteurella multocida, type a:3, was adsorbed with protease-digested p. multocida type 3 lipopolysaccharide (lps) to remove lps immunoreactivity. the lps-adsorbed antineuraminidase caused a 77% reduction in the neuraminidase activity of homologous p. multocida in an in vitro enzyme neutralization test. all 14 mice passively immunized with the adsorbed antineuraminidase were protected against challenge infection with homologous p. multocida in ...	1992	1496818
polypeptides associated with pasteurella multocida infection in rabbits.	polypeptides from whole cell preparations of pasteurella multocida serotypes a:12 and a:3 were separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and transferred to nitrocellulose paper. antigens were detected by immunoblot analysis, using sera from 3 groups of rabbits. sera were obtained from rabbits inoculated intranasally with p multocida serotype a:12 or a:3, from rabbits maintained in a rabbitry with enzootic p multocida a:12 infection, and from rabbits maintained in a r ...	1992	1497178
[the importance of dermonecrotoxin and dermonecrotoxoid of pasteurella multocida for the calf].	the i. m. application of dermonecrotoxin of p. multocida var. d led to an atrophy of nasal conchae, liver-swelling and to induration of liver and spleen. the intratracheal application caused a lobular pneumonia. the vaccination with toxoid resulted in an immunity against a challenge with toxin but not with p. multocida var. d. correlations between antitoxic serum-titers and immunity have to be investigated in future.	1992	1497586
chronic frontal sinusitis in dairy cattle: 12 cases (1978-1989).	chronic frontal sinusitis in 12 dairy cattle most often was associated with a history of dehorning, in which the sinus was entered (67%), or with respiratory tract disease (25%). the most common organisms isolated were actinomyces pyogenes and pasteurella multocida. signs of infection did not develop for months in some cattle and were often intermittent. the most common clinical signs included anorexia, lethargy, fever, frontal bone distortion, exophthalmos, abnormal posture, nasal discharge, an ...	1992	1500335
perceptual interactions between musical pitch and timbre.	these experiments examined perceptual interactions between musical pitch and timbre. experiment 1, through the use of the garner classification tasks, found that pitch and timbre of isolated tones interact. classification times showed interference from uncorrelated variation in the irrelevant attribute and facilitation from correlated variation; the effects were symmetrical. experiments 2 and 3 examined how musical pitch and timbre function in longer sequences. in recognition memory tasks, a tar ...	2006	1500873
[clinicobacteriological study of pasteurella multocida infection as a zoonosis. (2)--comparisons of p. multocida separated from patients and their pet dogs and cats].	a total of 17 strains of pasteurella multocida, of which 13 were isolated from patients treated at nihon university itabashi hospital or nihon university surugadai hospital between april, 1984 and march, 1991 and 4 from 1 dog and 3 cats kept by the patients, were evaluated with respect to their biochemical properties, sensitivity to drugs, and serotype. the isolated strains were all considered to be pasteurella multocida subsp. multocida because of the agreement of their responses to indole, sor ...	1992	1507482
serologic survey for selected arboviruses and other potential pathogens in wildlife from mexico.	during 1988 and 1989, a serologic survey of wildlife was conducted in northeastern mexico to determine the presence, prevalence, and distribution of arboviruses and other selected disease agents. eighty mammal specimens were tested. antibodies to vesicular stomatitis-indiana, venezuelan equine encephalitis-mena ii, rio grande virus, and vesicular stomatitis-new jersey were detected predominantly in small mammals. deer and mouflon (ovis musimon) had antibodies to bluetongue and epizootic hemorrha ...	1992	1512876
a pathologic and bacteriologic study on otitis media in swine.	a pathologic and bacteriologic study on otitis media in swine was performed on 237 swine, ranging in age from 1 day to 1 year. these 237 swine from eight selected farms were slaughtered due to unfavorable prognosis associated with clinical signs of illness. one hundred sixty-three (68.8%) of the 237 swine were found to be affected with otitis, though only a few swine showed clinical signs characteristic of the disease. one hundred fifty-one (63.7%), 53 (22.4%), and 39 (16.5%) had lesions in the ...	1992	1514220
long-term study of aerobic bacteria of the genital tract in breeding bitches.	the aerobic bacterial flora of the genital tract was characterized in 59 bitches in an 18-month study. the bitches represented 4 breeds and were from 3 kennels. collection of vaginal swab specimens for bacterial culturing was performed every month, except during estrus when specimens were collected every week (n = 826). the capsule of the swab containing transport media was broken before specimen collection to moisten the tip, which helped to reduce the number of negative cultures. all bitches h ...	1992	1524290
long-term study of aerobic bacteria of the genital tract in stud dogs.	the aerobic bacterial flora of the genital tract was characterized in 15 stud dogs in an 18-month study. the dogs represented 4 breeds and were from 3 kennels. bacterial samples from the prepuce and semen were collected every month, except in connection with matings, when they were collected weekly (464 samples). the dogs that were included all mated at least once during the study. the mean pregnancy rate, litter size, and pup mortality for the bitches with which they had mated were all within n ...	1992	1524291
pulp reactions to resin cements.	several formulas of a resin-filled cement that successfully passed a series of laboratory tests were evaluated for their pulp reactions in primates. their performance was compared to three controls: a positive control (silicate cement), a negative control (zinc oxide-eugenol) and a control group with the protection of calcium hydroxide. the chemical cure resin cement scored the lowest reactions for the 5-day evaluation. the intermediate and prolonged periods demonstrated no significant differenc ...	1992	1524752
carbohydrate specificity of the receptor sites of mistletoe toxic lectin-i.	the carbohydrate specificity of mistletoe toxic lectin-i (ml-i) was studied by haemagglutination-inhibition assay. the results indicated that ml-i has a broad range of affinity for gal alpha,beta linked sequences. the galabiose (e, gal alpha 1----4gal) sequence, a receptor of the uropathogenic e. coli ligand, was one of the best disaccharide inhibitors tested. the lectin also exhibits affinity for lac(gal beta 1----4glc), t(gal beta 1----3galnac), i/ii(gal beta 1----3/4glcnac) and b(gal alpha 1- ...	2006	1525184
pasteurella multocida septicaemia in two calves.		1992	1530558
[pasteurella multocida infection following injury by an inert material].		1992	1531266
fowl cholera epornitic: antigenic characterization and virulence of selected pasteurella multocida isolates.	an epornitic of fowl cholera involving turkey flocks of several farms within a 15-mile radius in utah was studied. pasteurella multocida strains isolated from birds in affected flocks were antigenically characterized as a:1, a:3, and b:4, based on capsular sero-grouping and somatic serotyping results. experimental exposure of poults with each of two strains representing the rarely reported capsular group b indicated that both were virulent.	1992	1533118
polymorphism in the rd (d6s45) gene.	the rd (d6s45) gene in the class iii region of the hla major histocompatibility complex encodes a protein normally containing 24 consecutive basic-acidic dipeptide repeats. we determined the frequency of variations in the number of repeats by use of the polymerase chain reaction. of 107 subjects 7 (3.3%) carried genes encoding 22 or 23 repeats. there was no difference in the frequency of such polymorphisms between normal individuals and those with systemic lupus erythematosus, a disease associat ...	1992	1534063
effects of cardioplegic solutions and their components on human saphenous vein contractility.	cardioplegic solution administration into the vein graft is an established method to ensure cardioplegic distribution beyond coronary artery stenoses. the ultrastructural demonstration of severe endothelial damage after cardioplegic exposure suggests that intravenous cardioplegic administration can contribute to early and late graft thrombosis. the direct effect on human saphenous vein contractility of three cardioplegic solutions and their components was compared. a solution with 30 mmol/l k+ a ...	1992	1540064
isolation of p multocida f-3, 4 from a stillborn snow leopard.		1992	1542981
septic arthritis due to pasteurella multocida.	we have reported two cases of septic arthritis caused by pasteurella multocida, the first, septic polyarthritis unrelated to animal contact and the other, septic monarthritis after a cat scratch. serious infections with this gram-negative bacillus must be treated with intravenous penicillin, ampicillin, or a third-generation cephalosporin; aminoglycosides are not effective. a high index of suspicion is appropriate when there is a history of a recent animal-inflicted wound, though infection may a ...	1992	1546361
heat shock decreases nuclear transport of 3,5,3'-triiodo-l-thyronine in clone 9 cells.	thyroid hormone, t3, enters cells through an energy-dependent, saturable process and/or passive diffusion. although the nucleus is the primary site of t3 action, exact mechanisms by which t3 is transported to nucleus are uncertain. in this report, initial cellular and nuclear uptake of t3 was determined using a rat liver cell line (clone 9), in which energy-dependent cellular t3 uptake was demonstrable. one to 5 mm sodium butyrate enhanced cellular t3 uptake with a concomitant increase in nuclea ...	1992	1547743
phylogeny of 54 representative strains of species in the family pasteurellaceae as determined by comparison of 16s rrna sequences.	virtually complete 16s rrna sequences were determined for 54 representative strains of species in the family pasteurellaceae. of these strains, 15 were pasteurella, 16 were actinobacillus, and 23 were haemophilus. a phylogenetic tree was constructed based on sequence similarity, using the neighbor-joining method. fifty-three of the strains fell within four large clusters. the first cluster included the type strains of haemophilus influenzae, h. aegyptius, h. aphrophilus, h. haemolyticus, h. para ...	1992	1548238
in utero infection due to pasteurella multocida in the first trimester of pregnancy: case report and review.	to our knowledge, we report the first case of in utero infection in humans due to pasteurella multocida in the first trimester of pregnancy. after antibiotic therapy was initiated, the mother recovered rapidly from bacteremia but the fetus was spontaneously aborted. pathological examination of the fetus and placenta revealed acute deciduitis and chorionitis, indicating an infectious etiology for the abortion. the clinical and pathological features of this case are compared with those of the five ...	1992	1554837
[patient care planning--a good chance for nursing].		2006	1559447
[detection of the nucleolar activity in alveolar macrophages of swine].	with the help of the toluidine blue-staining-technique different characteristic shapes of alveolar macrophage nucleoli were detected, indicating differences in the rrna synthesis activity of these cells. after application of a pasteurella multocida aerosol the percentage of alveolar macrophages with a high rrna synthesis increased. no correlation between the nucleolar activity and the efficacy of the clearance of aerogenously administered pasteurella could be measured.	1992	1559462
conditions for transformation of pasteurella multocida by electroporation.	conditions for electroporation of plasmid dna into pasteurella multocida were determined for use in developing a cloning system to study virulence factors of p. multocida. the highest efficiency of transformation (1.25 x 10(7) cfu/micrograms dna) was obtained when 7.6 x 10(10) cells of p. multocida strain r473 were electroporated at 12.5 kv/cm (10 ms, 5 ng of pvm109). transformation efficiencies of cells prepared at mid-log-phase were approximately 0.5 log10 lower than early, late, or stationary ...	1992	1560754
11 beta-amidoalkyl estradiols, a new series of pure antiestrogens.	in order to find new antiestrogens, devoid of any agonistic activity, a series of 11 beta-amidoalkyl estradiols were prepared. these compounds have been studied in comparison with tamoxifen (tam): in vitro, for their relative binding affinities (rba) for mouse and mcf-7 estrogen receptors (er) and for their antiproliferative effect on mcf-7 (estradiol or egf/pdgf stimulated) and ly2 human breast cancer cell lines; in vivo, for their uterotrophic/antiuterotrophic activities in the mouse and for t ...	1992	1562531
bite wounds and infection.	one of every two americans will be bitten by an animal or by another person at some point. bites account for approximately 1% of all visits to emergency rooms; injuries inflicted by dogs are most common. the bacteria involved in infection of bite wounds include pasteurella multocida, staphylococcus aureus, staphylococcus intermedius, alpha-hemolytic streptococci, capnocytophaga canimorsus, and other members of the oral flora. anaerobic bacteria are present in approximately one-third of bite woun ...	1992	1562653
cloning system for candida glabrata using elements from the metallothionein-iia-encoding gene that confer autonomous replication.	the yeast candida glabrata harbors two distinct gene families that encode metallothioneins (mts). one of these loci, the mt-iia locus, exhibits selective and tandem amplification in many wild type strains of c. glabrata. the present paper demonstrates that the amplified mt-iia gene contains autonomously replicating sequences (ars). these ars elements have been used to construct vectors capable of replicating in c. glabrata. the ars element(s) in the mt-iia gene were localized to a 457-bp segment ...	1992	1563627
cloning and sequence determination of a cdna encoding aspergillus nidulans calmodulin-dependent multifunctional protein kinase.	a partial cdna encoding aspergillus nidulans calmodulin-dependent multifunctional protein kinase (acmpk) was isolated from a lambda zap expression library by immunoselection using monospecific polyclonal antibodies to the enzyme. the sequence of both strands of the cdna (cmka) was determined. the deduced amino acid (aa) sequence contained all eleven consensus domains found in serine/threonine protein kinases [hanks et al., science 241 (1988) 42-52], as well as a putative calmodulin-binding domai ...	1992	1563634
bacteremia due to pasteurella multocida.	pasteurella multocida should be considered as a possible etiologic agent in any infection that is the result of an animal bite or scratch. because of its opportunistic capability, it should be included among the possible pathogens in bacteremia, particularly in any patient with immunosuppression or liver cirrhosis, especially if there is a history of animal exposure.	1992	1566154
comparative susceptibility of caponized and uncaponized tom turkeys to pasteurella multocida.	when susceptibility to virulent pasteurella multocida was compared, there was no significant (p greater than 0.05) difference between caponized and uncaponized tom turkeys. neither was there any significant (p greater than 0.05) difference between the surviving caponized and uncaponized toms in the development of serum anti-p. multocida antibody. however, at 28 weeks of age, the average live body weight of the caponized toms was significantly (p less than 0.05) lower than that of the uncaponized ...	1992	1567314
treatment of pasteurella multocida cellulitis with ciprofloxacin.		1992	1569315
[effect of body posture on heart rate and cardiocirculatory parameters in stress--implications for frequency-adapted pacemaker systems].	in order to study the influence of body position on cardiodynamics and the consequences for the regulation of rate-adaptive pacing, we examined variations of cardiocirculatory parameters with passive graded tilt from the erect to the supine position (90 degrees, 75 degrees, 60 degrees, 45 degrees, 30 degrees, 0 degrees) in 25 healthy subjects of both sexes under resting conditions and under conditions of exercise on a bicycle ergometer. using impedance cardiography combined with phonocardiograph ...	2002	1570725
nuclear morphometry for prediction of metastatic potential in early squamous cell carcinoma of the floor of the mouth.	quantitative morphometric analyses of the nuclear shape have been successfully used with prostatic carcinoma to predict tumor metastatic potential and provide the most sensitive indicator of tumor aggressiveness in the individual case. we have studied the nuclear morphometric characteristics of 22 patients with t1 and t2 squamous cell carcinoma of the floor of the mouth to see if a correlation existed between lack of nuclear roundness and presence of cervical metastatic disease. a significant di ...	2006	1571129
survival of toxigenic pasteurella multocida in aerosols and aqueous liquids.	the survival of toxigenic pasteurella multocida in air and liquids was studied to identify possible risk factors in the etiology of atrophic rhinitis. in aerosols, at low relative humidity (28%), the viability of toxigenic p. multocida 5 min after aerosolization was at least 22% of its initial value. viability at low relative humidity declined to 8% after 45 min. viability at high relative humidity (79%) was 69% after 5 min and declined to 2% after 45 min. survival of toxigenic p. multocida in l ...	1992	1575496
pasteurella multocida toxin. the characterisation of the toxin and its significance in the diagnosis and prevention of progressive atrophic rhinitis in pigs.		1992	1576005
characterization of the inhibition of interleukin 2 mrna accumulation by 12-o-tetradecanoylphorbol-13-acetate in primary lymphocytes.	we found previously that bovine lymph node cells (lnc) incubated with 12-o-tetradecanoylphorbol-13-acetate (tpa) for 18 h proliferate only to a limited degree on subsequent stimulation with concanavalin a (con a), or with the comitogenic combination of con a plus tpa. the lack of proliferation was traced to a lack of secretion of interleukin 2 (il-2). lack of secretion was paralleled by a decrease in il-2 mrna levels. in this study we further characterized how tpa pretreatment affected il-2 mrna ...	1992	1576243
cell surface characteristics and virulence in mice of pasteurella multocida.	the virulence of three avian strains of pasteurella multocida was evaluated in mice. strains p-1059i (serotype a:3) and its uncapsulated variant p-1059b and strain 2723 (serotype a:16) were compared. capsular material thickness after polycationic ferritin labelling of dextrose starch agar (dsa)-grown p. multocida was shown to vary with the strain and was not always related to virulence. addition of alpha,alpha' bipyridyl (bip) (160 microm) to the culture medium did not affect capsule production ...	1992	1576405
haemorrhagic septicaemia--a general review.		1992	1576525
further investigations on pasteurella multocida infections in feral birds injured by cats.	a total of 64 pasteurella multocida strains (46 out of 11 different feral bird species, partly injured by cat bites, and 18 strains originating from clinically healthy cats) were biochemically differentiated. as a result, 67.4% of the strains from feral birds and 61.1% from the cats were classified as the subspecies multocida, whilst 21.7% and 27.8% were identified as the subspecies septica. the percentage of frequency for both the subspecies was of a comparable order of magnitude from the birds ...	1992	1580104
pasteurella multocida toxin is a potent inducer of anchorage-independent cell growth.	the growth of many normal cells requires contact with an adhesive substratum, a requirement that is frequently abrogated in the transformed phenotype. we have explored pathways that can lead to the anchorage-independent growth of cultured rat-1 fibroblasts. pasteurella multocida toxin (pmt), a 146-kda mitogenic protein, caused a striking increase in the formation of colonies (greater than 200 microns) from single cells in soft agar. the magnitude of the effect of pmt was greater than that achiev ...	1992	1584759
internal medicine curriculum reform.		2006	1586112
changing the curriculum for internal medicine residency training.	the academic leadership of internal medicine is considering fundamental changes in the curriculum for internal medicine residency training. the impetus to change the curriculum is derived from various socioeconomic changes during the past 10 years. these changes have resulted in a drastically shortened length of stay of patients in hospitals, an emphasis on outpatient care by reimbursement agencies, and a sharp decline in the numbers of u.s. medical graduates selecting careers in internal medici ...	2004	1586113
[the ionized calcium in the blood of domestic chickens: dependence on age and sex].	in the present study concentration of ionized calcium and the correlation between total and ionized calcium in blood of domestic fowl and its dependence on age and sex were investigated. furthermore a possible influence of blood sampling procedure on the measured values was assessed. leghorn chickens of either sex, aged 3, 9, 25, and 80 weeks, respectively, were used. blood sampling was performed by vein-puncture and indwelling catheters, respectively, of both ulnaris vein and artery of animals ...	1992	1590033
cytological findings in bronchoalveolar lavage fluid from feedlot calves: associations with pulmonary microbial flora.	samples obtained by bronchoalveolar lavage (bal) were used to evaluate pulmonary cytology in 59 feedlot calves with clinical signs of respiratory disease (cases) and 60 clinically normal comparison calves (controls). many calves in both case and control groups had inflammatory changes in the lower respiratory tract, as determined by changes in proportions in the bal differential cell count. approximately 35% of cases and 40% of controls showed a normal differential cell count. it therefore appea ...	1992	1591654
effects of exposure of pregnant mice to chlordiazepoxide (cdp) on the development and ultrasound production of their offspring.	1. the effects were studied of injecting pregnant alderley park mice with the benzodiazepine agonist chlordiazepoxide (cdp) at doses of 10 and 30 mg/kg during the last 9-10 days of gestation on the early behaviour and development of their offspring. 2. all neonates were fostered to non-treated lactating dams to eliminate maternally-mediated effects. 3. early development and responses to anxiety-related situations were studied by recording body growth, righting reflex, rooting behaviour, cliff av ...	2005	1592226
crossmodal changes in the somatosensory vibrissa/barrel system of visually deprived animals.	cats deprived of vision from birth adapt remarkably well to their situation and show little behavioral impairment. they seem to compensate for their lack of vision by relying more on their auditory and tactile senses. we report here that the facial vibrissae, which are most important for tactile orientation in many animals, show supernormal growth in both cats and mice that have been deprived of vision from birth. furthermore, the whisker representation in the somatosensory cortical barrel field ...	1992	1594614
estimating the stage-specific numbers of hiv infection using a markov model and back-calculation.	the back-calculation method has been used to estimate the number of hiv infections from aids incidence data in a particular population. we present an extension of back calculation that provides estimates of the numbers of hiv infectives in different stages of infection. we model the staging process with a time-dependent markov process that partitions the hiv infectious period into the following progressive stages and/or substages: stage 1, infected but antibody negative; substages 2-3; antibody ...	1992	1594820
serological characterisation of pasteurella multocida strains isolated from wild ruminants as capsular serogroup b.		1992	1595164
intracerebroventricular immunization with trh-antiserum lowers blood pressure in spontaneously hypertensive rats.	centrally administered thyrotropin-releasing hormone exerts a well documented hypertensive effect. in this study, the possible physiological role of thyrotropin-releasing hormone in the central cardiovascular regulation was evaluated in spontaneously hypertensive rats receiving long-term (8-14 days) intracerebroventricular infusion of a heterologous antiserum to thyrotropin-releasing hormone. the effect of this passive immunization on the blood pressure was monitored from conscious animals by th ...	1992	1595355
ventriculopleural shunting used as a temporary diversion.	due to the limited absorptive capacity of the pleural cavity, infants and young children are not generally ideal candidates for ventriculopleural shunts. we report using chest cavities as alternate for temporary diversion of csf in a young child. venous access to the cervical region could not be utilized because of scarring from previous procedures, while peritoneal access was contraindicated due to repeated pseudocyst formation. pleural effusions were removed by thoracentesis when necessary, an ...	2006	1595400
equanimity.		2006	1595502
retinal vein occlusion.	retinal vein occlusion is a common form of retinal vascular disease, especially in middle-aged and older individuals. the diagnosis is based on the funduscopic finding of retinal vein dilatation in association with retinal hemorrhages and cotton-wool spots. the pathology can involve the entire venous system or can be limited to a branch of the central retinal vein. retinal vein occlusion can be distinguished clinically from diabetic retinopathy and other retinal diseases. treatment for the acute ...	2006	1595515
common infections in the elderly.	symptoms of infection in the elderly may be absent, vague or atypical. infection should be suspected when an elderly patient presents with a decline in well-being or with non-specific symptoms such as falls, dizziness, confusion, anorexia or weakness. common infections include bacterial pneumonia, urinary tract infection, intra-abdominal infections, gram-negative bacteremia and infection of decubitus ulcers. antibiotic therapy is not recommended for asymptomatic bacteriuria or locally infected d ...	2006	1595517
hyaluronic acid and a (1----4)-beta-d-xylan, extracellular polysaccharides of pasteurella multocida (carter type a) strain 880.		1992	1596931
pasteurella infection in a total knee arthroplasty.	hematogenous infection of a total joint arthroplasty is a serious complication that has well-known etiologies. one of the most unusual inciting events is a bite wound. pasteurella multocida is an anaerobic organism found in the mouths of mammals that has rarely been found to infect total knee arthroplasties. prompt recognition of such an infection and prophylactic treatment with a penicillinase-resistant penicillin should maximize the patient's opportunity to eradicate such an infection.	1992	1603610
[purification, amino acid composition and n-terminal sequence of the major protein (protein h) of the outer membrane of pasteurella multocida].	the major protein (protein h) of the outer membrane of pasteurella multocida was purified by size-exclusion chromatography after selective extraction with detergents. the protein forms homotrimers which are stable in the presence of sds at room temperature. upon treatment at 100 degrees c, the protein is fully dissociated by the detergent into monomers exhibiting an apparent molecular mass of 37 kda as estimated by electrophoresis. the amino acid composition of protein h is characterized by a lo ...	1992	1606514
pasteurella multocida infection in total knee arthroplasty. case report and literature review.	pasteurella multocida, a small gram-negative bacterium, is part of the normal mouth flora of many animals, including domestic cats and dogs. while commonly associated with infections in animals, it is a rare cause of human disease. the majority of pasteurella infections in humans occur with percutaneous inoculation of the organism following a bite by a cat or dog, although disease without antecedent animal exposure or with causal animal contact does occur. the spectrum of disease produced ranges ...	1992	1613522
brefeldin a enhances receptor-mediated transcytosis of transferrin in filter-grown madin-darby canine kidney cells.	the effects of brefeldin a (bfa) on transferrin (tf) transcellular transport, tf receptor (tfr) distribution, and tfr-mediated endocytosis in filter-grown madin-darby canine kidney (mdck) cells were studied. bfa (1.6 micrograms/ml) markedly enhanced the transcytosis of 125i-labeled tf (125i-tf) in both apical-to-basal and basal-to-apical directions; yet, bfa did not enhance the transcytosis of either native horseradish peroxidase (hrp) or membrane-bound hrp-poly(l-lysine) conjugates. furthermore ...	1992	1618847
[fundus plication with or without proximal selective vagotomy?].	the aim of this study was to determine the influence of proximal gastric vagotomy on the outcome after fundoplication. of 141 patients operated on for reflux disease between 1972 and 1988, 53 had fundoplication alone (group a) and 88 fundoplication combined with proximal gastric vagotomy (group b). the two groups were similar with regard to the severity of the reflux disease (esophagitis: a 69%, b 73%) but had a different incidence of concomitant ulcer disease (a 2%, b 55%). after a mean follow- ...	2006	1621082
pasteurella multocida infection after a tasmanian devil bite.		1992	1623089
characterization of pasteurella multocida from nasal cavities of piglets from farms with or without atrophic rhinitis.	a total of 137 strains of pasteurella multocida isolated from the nasal tracts of pigs with and without clinical atrophic rhinitis (ar) were studied for their biochemical, antigenic, and toxigenic characteristics. there were no major biochemical differences among the p. multocida isolates. capsular antigen types a and d were both present in the nasal cavities of the pigs with or without clinical ar. however, the prevalence of type d was higher on farms with pigs with ar. types a and d with diffe ...	1992	1624554
review of behavior on a disk from cms academic software: instructional programs for teaching teachers.	the programs on boad represent a set of useful simulations and demonstrations of learning phenomena that successfully convey important practical and theoretical information to students. the most successful modules deal with shaping and the selective effect of positive reinforcement on behavior. the range of examples is sufficiently broad to convey the generality of these learning phenomena, but the graphics and particular examples are better suited to the college classroom (for which they were d ...	1992	1626085
vaccine efficacy for reducing turbinate atrophy and improving growth rate in piggeries with endemic atrophic rhinitis.	two vaccines, based on formalin-killed whole cells of toxigenic pasteurella multocida type d and bordetella bronchiseptica combined with a partially toxoided cell extract of p multocida, were prepared with freund's incomplete adjuvant (vaccine 1) or by alum precipitation (vaccine 2). each was tested for safety and efficacy in reducing the severity of nasal turbinate atrophy and improving the growth rate of pigs in three western australian commercial piggeries with endemic atrophic rhinitis. in s ...	1992	1627085
transmission of pasteurella multocida on california turkey premises in 1988-89.	restriction endonuclease analysis (rea) of whole-cell dna was used to determine possible sources of pasteurella multocida for each outbreak of fowl cholera occurring in turkey flocks in eight commercial poultry companies in california from october 1988 to september 1989. over this period, 179 isolates of p. multocida were obtained from dead turkeys in 80 meat and breeder flocks on 43 premises. p. multocida was isolated from wildlife on five premises. isolates were characterized by subspecies, se ...	1992	1627098
restriction endonuclease analysis of pasteurella multocida isolates from three california turkey premises.	three california turkey premises that had repeated outbreaks of fowl cholera were studied for periods of 2 to 4 years. using biochemical, serologic, plasmid dna, and restriction endonuclease analyses of isolates of pasteurella multocida from turkeys and wildlife on the premises, strains of the organism were found to be enzootic on two of the premises. on the third, a variety of strains of p. multocida were isolated from fowl cholera outbreak flocks.	1992	1627099
vaccination of turkeys with cell-free culture filtrate of pasteurella multocida: effects of ultrafiltration and endotoxin removal.	cell-free culture filtrate (ccf) of pasteurella multocida strain r44/6 (serotype 3/4/9/12) was fractionated by ultrafiltration into fractions of less than 10,000, greater than 10,000, greater than 30,000, and 10,000 to 30,000 molecular weight (mw). the less-than-10,000-mw fraction contained little endotoxin comparable to bacteriologic medium; the 10,000-to-30,000-mw fraction had a moderate amount of endotoxin, whereas the greater-than-10,000- and greater-than-30,000-mw fractions contained high l ...	1992	1627112
cleavage of immunoglobulin a1, a2 and g by proteases from clinical isolates of pasteurella multocida.	several pasteurella multocida strains were examined for their ability to produce extracellular enzymes that cleave immunoglobulin a and g (ig a and ig g) molecules. two strains isolated from human pulmonary and genital infections produced proteases that cleaved human iga and igg, colostral iga and human myeloma iga1 and iga2. human igm was not degraded by these enzymes. examination of cleavage digests showed two main fragments with different electrophoretic mobilities. the two p. multocida strai ...	1992	1629898
swine leukocyte antigen and macrophage marker expression on both african swine fever virus-infected and non-infected primary porcine macrophage cultures.	swine leukocyte antigens (sla) and a macrophage specific marker were monitored on porcine macrophages cultured with or without macrophage colony stimulatory factor (m-csf) and on cells infected with african swine fever virus (asfv). sla expression was maximal either in the total cell extract or on the cell surface at 3-4 days of culture; after 4 days these values began to decrease. fluorescence analyses of immunostained macrophages cultured with or without m-csf indicated a major upward shift in ...	1992	1632065
use of rats to compare atrophic rhinitis vaccines for protection against effects of heat-labile protein toxin produced by pasteurella multocida serogroup d.	four bacterin-toxoid and three bacterin commercial vaccines against atrophic rhinitis were tested in rats for their capacity to immunize against the lethal and systemic effects of purified heat-labile protein toxin (d-toxin) produced by pasteurella multocida serogroup d. only one bacterin-toxoid vaccine stimulated sufficient immunity to prevent the death of all rats challenged with d-toxin. none of the vaccines prevented weight loss, leukocytosis or increases in serum complement titers in rats c ...	1992	1632076
[treatment procedure in humeral shaft fractures with primary or secondary radial nerve damage].	we give an account of 28 patients with fractured humerus diaphysis, suffering from primary and seven patients suffering from secondary lesion of the radialis nerve, all treated by operation. in each case the radialis nerve was exposed and the fracture was treated by fixation with compression plates. in case of primary lesions of the radialis nerve, we found intraoperative damages by traction (six times), contusions (seven times), intraneural hämatomas (six times) and for one time perforation of ...	2006	1636222
immunology of the bladder.	immunobiology techniques that once were the domain of research are increasingly being applied in the clinic. transitional epithelium of the bladder undergoes some recognized immunologic changes as it becomes malignant, and their detection may have prognostic value. examples of such changes are deletion of the abo(h) blood group antigens, inappropriate expression of lewis antigens, loss of beta-2 microglobulin and the mhc class 1 heavy chain, and alterations in the production of cellular adhesion ...	2006	1636238
aortic dissection following intraaortic balloon insertion: recognition by transesophageal echocardiography.		2006	1636606
[results of experimental immunization of calves with different pasteurella antigens].	calves immunised with different pasteurella antigens (inactivated whole cells, sodium chloride extract) where challenged two weeks after the second immunization with the homologous strain. the intracutaneous application of whole cells of p. haemolytica a1 and p. multocida a was effective. the incidence of pneumonia was reduced and the pneumonic lesions were less severe. the sodium chloride extract was not effective.	1992	1638965
iscom of bhv-1 envelope glycoproteins protected calves against both disease and infection.	a subunit vaccine in the form of immunostimulating complex (iscom) was prepared to contain the envelope glycoproteins of bovine herpesvirus type 1 (bhv-1). this iscom preparation was tested in a vaccination experiment on 4-month-old calves seronegative to bhv-1. in this experiment, four groups with three animals per group were used. two groups were vaccinated with the iscom preparation twice, four weeks apart, one group with 50 micrograms and the other with 100 micrograms per calf. the third gro ...	1991	1653508