Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| penetration of cefoxitin into cerebrospinal fluid and treatment of meningitis caused by gram-negative bacteria. | two patients with meningitis caused by antibiotic-resistant escherichia coli and klebsiella pneumoniae were treated successfully with intravenous cefoxitin plus oral probenecid. a total of 25 patients with central nervous system disorders that required a diagnostic spinal tap were also given cefoxitin, with or without probenecid, for determination of the degree of penetration into cerebrospinal fluid. in patients with uninflamed meninges, little or no cefoxitin entered after a single dose of 4-6 ... | 1979 | 400930 |
| infections due to endemic, multiply resistant gram-negative rods: sensitivity to and therapy with cefoxitin. | a nosocomial outbreak of infections due to bacteria resistant to multiple antibiotics evolved into an endemic prevalence of several antibiotic-resistant gram-negative rods. the resistance of these bacteria to available beta-lactam antibiotics, a variety of broad-spectrum agents, and available aminoglycosides other than amikacin led to an evaluation of cefoxitin, a beta-lactamase-resistant cephamycin. most multiply resistant isolates of klebsiella pneumoniae, serratia marcescens, and proteus mira ... | 1979 | 400932 |
| absence of clinical pneumonia following bronchoscopy with contaminated and clean bronchofiberscopes. | two hundred forty-nine fiberoptic bronchoscopy procedures were surveyed for the presence of bronchoscopy-related pneumonia. the first 103 procedures were performed during a period when the fiberscope was presemably contaminated with pseudomonas aeruginosa. chart review of these 103 procedures and prospective epidemiologic surveillance of the remaining 146 procedures revealed no cases of bronchoscopy-related pneumonia. | 1977 | 401481 |
| susceptibility to fosfomycin of hospital strains isolated in nantes (france). frequency of mutation to resistance. | susceptibility of 760 bacterial isolates to fosfomycin has been determined by the agar dilution method. the mics of 364 strains have been determined by comparison of agar alone and agar plus glucose-6-phosphate. this later enhances the activity of fosfomycin. lastly, we studied frequency of mutation toward resistance for 109 susceptible strains. we obtained 88 stable mutants. | 1977 | 401717 |
| r plasmids coding for gentamicin, tobramycin, and carbenicillin resistance in serratia, klebsiella and escherichia coli strains from a single clinical source. | serratia marcescens, klebsiella sp. and escherichia coli strains bearing transferable resistance to aminoglycoside antibiotics, namely, gentamicin, tobramycin, kanamycin, streptomycin, lividomycin, and carbenicillin, as well as to a series of more classical drugs, began to emerge in materials from the frankfurt university hospital. plasmids from serratia, klebsiella, and e. coli exhibit a broad host range in that they are transferable to e. coli, proteus mirabilis and salmonella typhimurium rece ... | 1977 | 401718 |
| fosfomycin, antimicrobial activity in vitro and in vivo. | antibacterial activities of fosfomycin were investigated both in vitro and in vivo for the purpose of comparative evaluation on its fundamental properties with other antimicrobial agents. the mic was determined with nutrient agar (difco) inoculated with one loopful of 1,000-fold dilution (about 10(6) cells/ml) of bacterial suspension cultured overnight in nutrient broth. this substance showed antibacterial activity to most gram-positive and gram-negative bacteria, being strongest to enterobacter ... | 1977 | 401721 |
| evolution of sensitivity to fosfomycin at jimenez diaz foundation. | the sensitivity to fosfomycin of more than 8,000 strains of bacteria isolated from products recevied by the laboratory between 1972 and 1974 has been studied. some were studied by the dilution technique in a solid medium and the remainder was studied by diffusion. a single 50-mug disc was used and the strains inhibited by concentrations of less than 64 mug/ml or with inhibition halos of 15 mm diameter or more were considered sensitive. it is clear from this study that there are no significant ch ... | 1977 | 401722 |
| comparison of amikacin and tobramycin in the treatment of infection in patients with cancer. | two new aminoglycoside antibiotics, tobramycin and amikacin, were compared in a randomized study of the treatment of infections in patients with cancer. for the identified infections, the response rate for tobramycin was 60% and for amikacin was 64%. pneumonia, urinary tract infection, and septicemia were the most frequent infections. most (78%) of the identified pathogens were gram-negative bacilli; klebsiella pneumoniae, escherichia coli, and pseudomonas aeruginosa were the most frequently iso ... | 1977 | 401853 |
| isolation of drug-resistant bacteria from newborn infants. | the fetus is known to be bacteria-free and is contaminated with bacteria during birth. we examined drug-resistant bacteria in feces of new-born infants to know the distribution of drug-resistant bacteria in a hospital. among 76 infants examined, we could isolate drug-resistant strains of bacteria from 65 infants (86%). we collected 110 drug-resistant strains of escherichia coli, klebisella pneumoniae, and pseudomonas aeruginosa, and could isolate 53 strains (48%) carrying r plasmids; they being ... | 1977 | 402039 |
| in vitro activity of netilmicin, gentamicin, and amikacin. | the in vitro activity of netilmicin (sch 20569), a new semisynthetic derivative of gentamicin, was compared with that of gentamicin and amikacin. one hundred and ninety-two clinical isolates of enterobacteriaceae, pseudomonas aeruginosa, and staphylococcus aureus were tested using both agar and broth dilution techniques. netilmicin was comparable to gentamicin, with the following exceptions: (i) for serratia marcescens and p. aeruginosa, gentamicin was more active than netilmicin; (ii) all strai ... | 1977 | 402104 |
| [toxicity of bacterial polysaccharides (a review of the literature)]. | 1977 | 402887 | |
| gamma heavy chain disease--presenting as pancytopenia and splenomegaly. | a patient with gamma heavy chain disease (franklin's disease) was discovered during evaluation for pancytopenia and splenomegaly. lymphadenopathy, palatal edema, and infiltration of the bone marrow palatal edema, and infiltration of the bone marrow with abnormal cells were all absent. serum and urine protein electrophoresis demonstrated a monoclonal protein migrating in the beta region. immunoelectrophoresis showed that it reacted with antibodies against the fc fragment of igg heavy chains (gamm ... | 1977 | 403613 |
| [problems of ambulatory pharmacotherapy. 8. a model for antibiotik-rank series in urinary tract infections]. | 1977 | 403689 | |
| gram-negative rod bacteremia: microbiologic, immunologic, and therapeutic considerations. | during the last 2 decades, gram-negative rod bacteremia has become the leading infectious disease problem in american hospitals. with improvements in conventional microbiologic techniques, bacteremic infection can be diagnosed reliably within 3 days using only three sets of cultures. clinical management still requires aggressive, presumptive use of antimicrobials in patients with the most adverse host factors. in the latter group, the use of combinations of antibiotics that interact synergistica ... | 1977 | 403841 |
| chemical modification of neamine. | the aminocyclitol antibiotic neamine has been modified chemically by removing one or two hydroxyl groups from the 2-deoxystreptamine moiety to give 5- and 6- deoxyneamines (5 and 10), as well as 5,6-dideoxyneamine (15). their antimicrobial activities were determined against several microorganisms, including kanamycin-resistant strains. | 1977 | 404040 |
| [increase in the non-specific resistance to infection in mice after oral administration of 2 synthetic glycopeptides with adjuvant activity]. | two synthetic glycopeptides (murnac-l-ala-d-isogln and murnac-l-ala-d-glu), having adjuvant activity, were shown to enhance non-specific resistance to infection against k. pneumoniae. these compounds were active by various routes including oral administration and even if administered after the challenge. two steroisomers lacking adjuvant activity did not protect the infected mice. | 1977 | 404070 |
| [reservoir for bacteria of urinary tract infections in urologic patients (author's transl)]. | many infections of the urinary tract, especially after surgical treatment are nosocomial infections. the etiological bacteria could only be found in the urine of the infected patients and in the faecal flora of nearly 40% of all stationary patients. the so called "problem bacteria": klebsiella, proteus rettgeri, pseudomonas showed increasing drug resistance during the observed period between 1972-1975. the bacteria isolated from the faecal flora also showed multiple drug resistance. thus we conc ... | 1977 | 404234 |
| sensitivity of gram-negative bacteria to six aminoglycoside antibiotics. | an in vitro study of the susceptibility of 201 newly isolated strains of gramnegative bacteria to six aminoglycoside antibiotics (kanamycin, amikacin, gentamicin, tobramycin, sisomicin and netilmicin) was performed by the twofold dilution method in fluid medium. both the minimal inhibitory concentration and the minimal bacteridical concentration were determined. overall, tobramycin seemed the most effective of the drugs studied. netilmicin, the new derivative from sisomicin, compared favourably ... | 1977 | 404254 |
| enhancement of nonspecific immunity to bacterial infection by cord factor (6,6'-trehalose dimycolate). | the capacity of mycobacteria to enhance the nonspecific resistance of mice to bacterial infections was related to the presence of cord factor. after enzymatic digestion and delipidation, cell walls lost their immunopotentiating activity, which was restored, however, by the addition of cord factor. cord factor administered alone protected mice effectively against virulent organisms unrelated to mycobacteria. moreover, although this glycolipid is usually injected as a solution in mineral oil, our ... | 1977 | 404368 |
| structure-activity relationships among the o-acyl derivatives of leucomycin. correlation of minimal inhibitory concentrations with binding to escherichia coli ribosomes. | the synthesis, antimicrobial activity, and binding to ribosomes of leucomycin and leucomycin derivatives are described. in general, the binding of the leucomycins and the leucomycin derivatives to ribosomes correlated with their antimicrobial activity. some 2'-o-acyl derivatives apparently underwent gradual hydrolysis during antimicrobial assays, for their binding to ribosomes was poor compared to their relatively good antimicrobial activies. correlation between antimicrobial activity and bindin ... | 1977 | 404425 |
| frequency of heavy-metal resistance in bacteria from inpatients in japan. | 1977 | 404561 | |
| [diagnosis of bacterial infections of the urinary tract]. | the aetiopathogenesis of bacterial infections of the urinary ways and the techniques used to isolate and identify the bacteria present in the urine are considered. the following aspects are covered: 1) introduction (clinical microbiology); 2) urine and bacterial multiplication; 3) diagnostic techniques in urinary way infections; 4) urine leucocyte count; 5) urine bacteria count; 6) guidelines for applying bacteriological research; 7) recurrent infections of the urinary ways; 8) diagnosis of the ... | 1977 | 404596 |
| bactericidal activity of amikacin and gentamicin. | using the membrane filtration method bactericidal activity of amikacin and gentamicin as a function of time and concentrations was determined. amikacin was bactericidal against all pseudomonas aeruginosa (n = 7) and klebsiella pneumoniae strains (n = 8) tested. in 5 of the 7 p. aeruginosa and 3 of the 8 k. pneumoniae strains we saw a secondary regrowth at 24h. there was no difference between amikacin and gentamicin. the experiments to determine the effect of concentration on bactericidal activit ... | 1977 | 405182 |
| depressed mononuclear leukocyte chemotaxis in thermally injured patients. | 1977 | 406323 | |
| [fulminat courses of sepsis in newborn infants and infants]. | 1977 | 406522 | |
| immunochemical evidence for the difference between coenzyme-b12-dependent diol dehydratase and glycerol dehydratase. | klebsiella pneumoniae atcc 25955 (formerly named aerobacter aerogenes pzh 572, warsaw), which is known to produce coenzyme-b12-dependent glycerol dehydratase when grown anaerobically in a glycerol medium, formed coenzyme-b12-dependent diol dehydratase in a 1,2-propanediol-containing medium. both the diol dehydratase and the glycerol dehydratase produced by the organism catalyzed the conversion of glycerol, 1,2-propanediol and 1,2-ethanediol to the corresponding aldehydes and underwent concomitan ... | 1977 | 407082 |
| rapid concentration of bacteriophages from aquatic habitats. | 1977 | 407206 | |
| enhancement of the sensitivity of the limulus assay for the detection of gram negative bacteria. | 1977 | 407207 | |
| a simple method for determining bacterial susceptibility to aminoglycosides. | a method is described of determining the susceptibility of enterobacteria to four amino-glycosides by means of an antibiotic diffusion method. the results are exose obtained by a method that involved titration in agar plates and the use of a multi-point inoculator. a statistical analysis showed that the diffusion method gave accurate reproducible results. the antibiotic can be incorporated into paper disks, paper strips or agar ditches and the calculation converting the measured zones of inhibit ... | 1977 | 408495 |
| effect of systemic antibiotics on the microbial flora of the external ear canal in hospitalized children. | the effect of antibiotic therapy and hospitalization on the external ear canal flora was investigated in 131 children. fifty-eight percent of the patients receiving antibiotic therapy had gram-negative bacilli or yeasts in their external ear canal, compared with 17% of the patients who were hospitalized for ten days or longer and only 3% of the patients who were hospitalized for short periods. antibiotic therapy is the major factor in determining the colonization rate of the external ear canal w ... | 1977 | 408786 |
| synergy of vancomycin with penicillins and cephalosporins against pseudomonas, klebsiella, and serratia. | 1977 | 408984 | |
| bacterial adherence to nasal mucosal cells. | the ability of several bacterial species to adhere to human nasal mucosal cells and their distribution on nasal mucosal surfaces was studied. staphylococcus aureus, staphylococcus epidermidis, streptococcus pyogenes, and pseudomonas aeruginosa adhered to scraped nasal mucosal cells. in contrast, viridans streptococci and klebsiella pneumoniae exhibited feeble or no adherence to nasal mucosal cells. s. aureus affinity for the nasal mucosal cells of carriers of s. aureus was greater than for those ... | 1977 | 409676 |
| patterns and mechanisms of emergence of resistance to amikacin. | emergence of gram-negative bacilli resistant to amikacin occurred in five of 96 patients treated. three of the five instances were associated with clinical failure and arose during therapy for an infection caused by a pathogen also susceptible to gentamicin. the other two episodes were associated with colonization. the enzyme aminoglycoside-6'-acetyltransferase, which inactivates amikacin, was found in serratia marcescens. decreased permeability to amikacin was shown in four isolates of pseudomo ... | 1977 | 409785 |
| [the basic studies on chemotherapy in urinary tract infection due to organisms with resistance to antibiotics (author's transl)]. | 1977 | 409865 | |
| bacterial sensitivity to the aminoglycosides. | from the reports of bacterial sensitivity testing reviewed here, it can be concluded that gentamicin has currently a very broad spectrum, with few resistant organisms. gentamicin, amikacin, and tobramycin are the most effective of the aminoglycosides against pseudomonas. they are also effective against escherichia, salmonellae, staphylococci, pasteurellae, klebsiella, and others; they are less effective against streptococci. streptomycin is effective but bacterial resistance to it develops very ... | 1977 | 409927 |
| isolation of an iron-molybdenum cofactor from nitrogenase. | a method for the isolation of an iron-molybdenum cofactor (femoco) from component i of nitrogenase is described. this method is used to isolate femoco from aerobic, anaerobic, facultative, and photosynthetic nitrogen-fixing organisms. the fe/mo ratio in the femoco from azotobacter vinelandii and clostridium pasteurianum is 8:1. the femoco contains six atoms of acid-labile sulfide per eight fe atoms. crystalline component i from a. vinelandii contains 2 mo, 33 fe, and 27 acid-labile sulfide atoms ... | 1977 | 410019 |
| septicaemia in the tropics. a prospective epidemiological study of 146 patients with a high case fatality rate. | a prospective study showed that during the first 6 months of 1976, 146 patients out of a total of 3938 admitted to a hospital in nigeria were suffering from septicaemia, or developed the condition while in hospital. findings differed from those reported from developed countries in that the majority of infections were community acquired, those most frequently and severely affected were the very young, and salmonella spp. and staphylococcus aureus were the most important pathogens. however, other ... | 1977 | 410093 |
| studies on 4 c stored frozen-reconstituted red blood cells. i. bacterial growth. | a knowledge of the growth rates of various organisms at the storage temperature of 4 c in the different suspending media used for red blood cells would aid the extension of the thawed storage time of frozen-reconstituted blood beyond the 24 hours allowed by the food and drug administration. knowing these rates, a prediction could be made that the growth rate would be sufficiently slow and the unit (sterile or minimally contaminated) could be given safely after a longer storage period. the studie ... | 1977 | 410123 |
| [a new type of ointment base: investigations on its antimicrobial properties (author's transl)]. | a new ointment base (pen 32) consisting of polyalcohols prevents the growth of bacteria and fungi in concentrations above 25% (mg/mg). in a concentrated form the ointment base exhibited excellent bactericidal and fungicidal effects in vitro. this property enables the ointment base to be employed without preservatives. | 1977 | 410167 |
| activity of netilmicin compared with those of gentamicin and tobramycin against enterobacteria and pseudomonas aeruginosa. | the inhibitory activity of netilmicin against 500 isolates of gram-negative bacteria was compared with those of gentamicin and tobramycin. netilmicin was considerably less active than tobramycin and slightly less inhibitory than gentamicin for pseudomonas aeruginosa but was at least as active against escherichia coli and klebsiella pneumoniae as were the other two antibiotics. a few klebsiella and serratia isolates resistant to gentamicin and tobramycin were inhibited by netilmicin. all three an ... | 1977 | 410361 |
| synergistic activity of trimethoprim and amikacin against gram-negative bacilli. | the in vitro effect of trimethoprim on the inhibitory and bactericidal activity of amikacin against 20 strains each of klebsiella pneumoniae and serratia marcescens, 15 strains of escherichia coli, and 10 strains of pseudomonas aeruginosa was examined by the checkerboard technique in microtiter plates. trimethoprim had a synergistic effect on the inhibitory and bactericidal activity of amikacin against the majority of non-pseudomonas strains tested. the mean +/- standard deviation fractional inh ... | 1977 | 410362 |
| effect of some bacterial products on platelet electrophoretic mobility (pem). | bacterial lps, used in our experiments, are able to decrease pem at concentration of 100 microgram/ml after incubation with 1 x 10(7) platelets/ml for 30 min at 37 degrees c. such effect is statistically significant for bacteroides fragilis lps, s. enteritidis and s. typhi. e. coli lps 026:b6 w and e. coli 055:b5 w are not effective at all, s. minnesota (incomplete) lps 595 and 345 free of 0-polysaccharide and partially lacking core in their molecule did not influence pem, while s. minnesota lps ... | 1977 | 410424 |
| [azlocillin--a new penicillin against pseudomonas aeruginosa and other gram-negative bacteria]. | 1977 | 410735 | |
| a third beta-galactosidase in a strain of klebsiella that possesses two lac genes. | klebsiella strain re1544 contains two lac operons, one on the chromosome and one on a lac plasmid. a mutant of re1544, in which the lacz genes of both operons produce no active enzyme, was found to synthesize a beta-galactosidase that hydrolyzes ortho-nitrophenyl-beta-d-galactopyranoside but not lactose. synthesis of this beta-galactosidase (bgase-iii) is induced by lactose but not by isopropyl-1-thio-beta-d-galactopyranoside or methyl-beta-d-thiogalactopyranoside. in both the regulation of synt ... | 1977 | 410780 |
| [pharmacological and clinical studies on s-6436 in urinary tract infections (author's transl)]. | 1977 | 411847 | |
| [clinical and pharmacological evaluation of s-6436 (long acting preparation of cephalexin) in urinary tract infections (author's transl)]. | 1977 | 411848 | |
| [development of a new quantitative in vitro test for chemical disinfectants (author's transl)]. | 1977 | 412352 | |
| [development of a new testmethod for surface disinfection procedures. iii. the impression method: influence of the test surface material and the types of microorganisms on the recovery rate (author's transl)]. | the preceding test results appear to favour the impression method used for the testing of surface disinfection procedures. further investigations were concerned with the selection of a suitable germ carrier. the high recovery rate of the bacteria and the invariably uniform quality of the germ carrier are the decisive criteria. since a dependence on the type of germ was also to be expected, we checked staph. aureus, str. faecalis, e. coli, kl. pneumoniae and p. aeruginosa for their behaviour on ... | 1977 | 412353 |
| [development of a new testmethod for surface disinfection procedures. iv. natural bacterial dying rates and their modification by environmental influences (author's transl)]. | 1977 | 412354 | |
| [development of a new testmethod for surface disinfection procedures. v. the reduction of germs by disinfection (author's transl)]. | 1977 | 412355 | |
| [development of a new testmethod for surface disinfection procedures. vii. proposal for the method (author's transl)]. | based on the findings obtained from the previous experiments (information i-vi), a proposal is made for the examination of surface disinfection procedures under conditions roughly resembling those prevailing in practice. this test allows the action of the disinfectant to be calculated, while making due allowance for the natural rate of kill. the results of three tests with a liminally effective disinfectant concentration extensively agreed with each other. this permits the conclusion that the me ... | 1977 | 412356 |
| emergence in a burn center of populations of bacteria resistant to gentamicin, tobramycin, and amikacin: evidence for the need for changes in zone diameter interpretative standards. | from july 1974 through june 1976, a number of isolates of escherichia coli, klebsiella pneumoniae, and pseudomonas aeruginosa from the burn center exhibited a shift to smaller zone diameters with gentamicin than did isolates from the general hospital population. although many had zone diameters >/=13 mm and would have been considered susceptible by this breakpoint, they were found to have minimal inhibitory concentrations (mics) of >/=8 mug of gentamicin per ml by agar dilution testing. zone dia ... | 1977 | 412464 |
| noxythiolln-resistant organisms in a district general hospital. | twelve strains of pseudomonas aeruginosa, three strains of klebsiella aerogenes, and two strains of escherichia coli were found to be resistant to noxythiolin. some of the pseudomonads were isolated from patients in the same ward, not all of whom were on noxythiolin treatment. the strains from these patients were indistinguishable from each other on phage typing, which suggested cross-contamination. no gram-positive organism was found to be resistant to noxythiolin. noxythiolin should not be use ... | 1977 | 412549 |
| in vitro activity of netilmicin (sch 20569) against bacterial isolates from ill children. | a new aminoglycoside antibiotic, netilmicin, was tested against 306 clinical isolates from ill children and compared with sisomicin and gentamicin. activity against enterobacteriaceae was similar to that of gentamicin but less than that of sisomicin. two gentamicin-resistant strains of enterobacteriaceae (klebsiella, mic 6.25 microgram/ml, escherichia coli, mic 12.5 microgram/ml) were susceptible to netilimicin (mic 3.12 microgram/ml). netilmicin was ineffective against almost all strains of pse ... | 1978 | 412647 |
| antimicrobial synergism in the therapy of gram-negative rod bacteremia. | to determine if antimicrobial synergism might affect the results of treatment of gram-negative rod infections, 444 bacteremias from 1972 through 1974 were studied. on these, 173 were treated with two antibiotics to which the infecting organisms were sensitive. clinical responses were observed in 80% of 83 cases where antibiotic activity was synergistic, as defined by a minimum inhibitory concentration (mic) of each antibiotic in combination being one-fourth or less than the mics of individual dr ... | 1978 | 412648 |
| [bacteria and resistance patterns in bacteriuria of hospitalized patients (author's transl)]. | during different periods in 1976 and 1977 the bacteria of hospitalized patients were selected at random in significant bacteriuria. the species determination was carried out exactly and the susceptibility to beta-lactam-and aminoglycoside antibiotics was investigated using the quantitative tube dilution test. the bacterial spectrum of 941 isolated strains is shown in table i. e. coli was found in 50% only. the spectrum of bacteria is different in the various hospitals, caused by regional phenome ... | 1977 | 412776 |
| experimental evaluation of hr756, a new cephalosporin derivative: pre-clinical study. | hr 756 is a new cephalosporin derivative suitable for parenteral use. the compound possesses an unusally broad spectrum of antibacterial activity especially against gram-negative bacteria. besides escherichia coli, salmonella, klebsiella, indole-negative proteae and other species also indol-positive proteae, serratia marcescens, enterobacter and many pseudomonas aeruginosa strains are inhibited by this compound. hr 756 is stable to most of the beta-lactamases produced by gram-negative organisms. ... | 1977 | 413795 |
| possible beta-lactamase activities detectable in infective clinical specimens. | biological beta-lactam antibiotic-inactivating activities were detected in bacteriuria and suppurating pleural fluids. clinical specimens were sterilized with membrane filters and the amounts of ampicillin and/or cephalothin which were being inactivated by 1 ml of each filtrate were determined. in general, filtrates which originally yielded klebsiella sp. tended to show activity against ampicillin; whereas those yielding enterobacter sp. and pseudomonas aeruginosa showed activity against cephalo ... | 1977 | 413821 |
| pyocine typing and drug resistance of pseudomonas aeruginosa. | 1977 | 413824 | |
| the formation of germtubes by candida albicans, when grown with staphylococcus pyogene, escherichia coli, klebsiella pneumoniae, lactobacilius acidophilus and proteus vulgaris. | the formation of germtubes by twelve clinical isolates of c. albicans was studied in human serum containing per millilitre 10(3) to 10(9) organisms as: staphylococcus pyegene, escherichia coli, klebsiella pneumoniae, lactobacillus acidophilus and proteus vulgaris. all the five bacteria inhibited formation of germtubes by c. albicans at all concentrations and the percent germtube formed diminished with increasing concentration of the bacteria. lactobacillus acidophilus inhibited the formation of ... | 1977 | 414139 |
| [recommendations for the testing and the evaluation of the efficacy of chemical disinfectant procedures (author's transl)]. | 1977 | 414483 | |
| rapid enumeration of fecal coliforms in water by a colorimetric beta-galactosidase assay. | the colorimetric beta-galactosidase assay is based upon the enzymatic hydrolysis of the substrate o-nitrophenyl-beta-d-galactoside (onpg) by fecal coliforms. this technique provides an estimate of the fecal coliform concentration within 8 to 20 h. a 100-ml portion of test sample was passed through a 0.45 micrometer membrane filter. this filter was then incubated at 37 degrees c for 1 h in ec medium followed by the addition of filter-sterilized onpg. the incubation was continued at 44.5 degrees c ... | 1978 | 414659 |
| role of the mitochondrial protein synthesis is the catabolite repression of the petite-negative yeast k.lactis. | 1978 | 414753 | |
| [cross microbial antigens of the human bronchopulmonary apparatus]. | the work was undertaken to assess the antigenic affinity of some neisseria perflava, klebsiella pneumoniae, staphylococcus aureus strains serving as active sensitinogen of the human broncho-pulmonary apparatus. with the aid of the complement fixation test, precipitation after ouchterolony, and immunoelectrophoresis there was established the presence of a series of similar antigenic determinants common for all the three microbes and for determinant responsible for the cross reactions of two micro ... | 1978 | 414802 |
| comparative immunological studies on arylsulfatase in bacteria of the family enterobacteriaceae: occurrence of latent arylsulfatase protein regulated by sulfur compounds and tyramine. | the arylsulfatases of 21 strains of the family enterobacteriaceae were compared by measuring their enzymatic activities and immunological reactivities. enzyme formation under repressing, nonrepressing, and derepressing conditions was tested. antiserum prepared against pure arylsulfatase from klebsiella aerobgenes w70 was tested against the enzyme extracts from the strains using double diffusion, quantitative precipitation, and immunoelectrophoresis. no close relationship was found between arylsu ... | 1978 | 415041 |
| [recognition of bacterial infections in newborns by measuring specific antibody-titres (author's transl)]. | antibodies were measured in 172 unselected neonates against mixed polyvalent antigens derived from e. coli, klebsiella, ps. aeruginosa and proteus spp. respectively, using a modification of the indirect haemagglutination technique according to neter. 120 of these neonates with no evidence of infection served as controls. 6 out of 8 children with proven e. coli septicaemia had either raised titres or significant rises in titre. five further neonates with septicaemia, four due to klebsiella and on ... | 1978 | 415229 |
| uptake of (methyl-14c)-sisomicin and (methyl-14c)-gentamicin into bacterial cells. | eight sensitive strains (two staphylococcus aureus, two escherichia coli, two pseudomonas aeruginosa and two klebsiella pneumoniae) and four resistant pseudomonas aeruginosa strains were used to study uptake of sisomicin and gentamicin by the bacterial cells. in eleven out of the twelve organisms studied employing (methyl-14c)-sisomicin and (methyl-14c)-gentamicin, uptake of the former was found higher that that of the latter. in one organism, the uptake of the two antibiotics was similar. this ... | 1978 | 416011 |
| [a case of klebsiella liver abscess developing septic shock with dic (author's transl)]. | 1977 | 416154 | |
| [effect of synthetic iron chelating agensts and of a source of carbohydrate nutrition on catechol biosynthesis by klebsiella aerogenes]. | 1978 | 416325 | |
| respiratory infection in an intensive care unit. | a postmortem bacteriological study of black children in a respiratory intensive care unit showed that pseudomonas aeruginosa was the most common opportunistic pathogen and that it usually complicated a viral infection. in a parallel study of non-debilitated patients in general hospital wards klebsiella aerogenes and escherichia coli were the most frequently isolated organisms. counter-immuno-electrophoresis was used for the identification of pseudomonas-precipitating antibody in serum and trache ... | 1977 | 416503 |
| [automatic disinfection of fiberendoscopes (author's transl)]. | bacteremia following endoscopy of the gastrointestinal tract in patients with impaired resistance even fatal septicemia has been reported. transmission of pathogenic bacterias via endoscopes has been described. we could demonstrate a considerable high number of gramnegative bacteria obtained from biopsy channel of fiberendoscopes after conventionell cleaning of the instruments. in seven different endoscopy units we found high bacterial contamination of all 22 fiberendoscopes. pseudomonas aerugin ... | 1977 | 416628 |
| septic induced acute gastric erosions: the role of cimetidine. | 1978 | 417217 | |
| granulocyte transfusions for patients with severe thermal burns. | ten severely burned (greater than 50% bsa) pediatric and young adult patients developed 19 episodes of clinical sepsis of four or more days duration. during eight of the 19 septic episodes the patients received granulocyte transfusions (median, four; range, two to seven). risk variables, types and prevalence of infections, mainly pseudomonas aeruginosa and antibiotic regimens were similar for all the septic episodes studied. all eight episodes (100%) resolved in the transfused group while eight ... | 1978 | 417432 |
| lactose metabolism in klebsiella pneumoniae strains growing in chemostat culture [proceedings]. | 1978 | 417955 | |
| heterologous transfection with bacteriophage phix174 dna: and improved system. | a highly efficient and much more reproducible system for the heterologous transfection of several kinds of gram-negative bacterial spheroplasts with bacteriophage phix174 dna was established. by mild washing of the speroplasts, the efficiency of transfection of all non-host heterologous bacterial species tested increased one or more orders of magnitude in producing the progeny phages and/or the infectious intermediates. using the improved heterologous transfection systems, it has become clearer ... | 1978 | 418813 |
| asthma, high-dose corticosteroids and klebsiella meningitis. | a side-effect of high-dose corticosteroid therapy, namely the development of kebsiella meningitis, in an asthmatic patient is reported. the possible mechanisms involved are discussed. | 1979 | 424938 |
| skin and soft tissue polymicrobial infections from intravenous abuse of drugs. | skin and soft tissue infections were studied in 21 seriously ill narcotic addicts who had been admitted to hospital. subcutaneous abscesses were present in 14 patients; cellulitis was noted in 3, pyomyositis in 2 and necrotizing fasciitis in 2. in four patients there was septicemia. infections in 14 patients (66.6 percent) were associated with anaerobic bacteria, which were the exclusive isolates in 6 patients. in seven patients (33.3 percent) isolates were exclusively aerobic bacteria and in ei ... | 1979 | 425502 |
| caroli's: a surgical challenge. | a patient operated upon for acalculous cholecystitis was later found to have caroli's disease, congenital ectasis of intrahepatic bile ducts. cholangitis, calculi and abscesses occurred in both lobes of the liver. sepsis was not controlled despite open drainage, hepatic segmentectomy and ductal lavage with antibiotics and saline. at autopsy the liver contained a dozen unsuspected cavities filled with calculi, bile and pus. diagnosis of caroli's disease is best made by operative cholangiography i ... | 1979 | 426375 |
| cefatrizine activity compared with that of other cephalosporins. | cefatrizine, a new orally administered cephalosporin, was tested against 400 clinical isolates. cefatrizine had excellent activity against gram-positive cocci, inhibiting all except enterococci at minimal inhibitory concentrations below 1 mug/ml. cefatrizine inhibited the majority of escherichia coli, klebsiella pneumoniae, proteus mirabilis, and salmonella at concentrations below 12.5 mug/ml. although cefatrizine was not hydrolyzed by many beta-lactamases, it did not inhibit a number of strains ... | 1979 | 426514 |
| hr 756, a new cephalosporin active against gram-positive and gram-negative aerobic and anaerobic bacteria. | the in vitro activity of hr 756, 7-[2-(2-amino-4-thiazolyl)-2-(z)-(methoximino)acetamido] cephalosporanic acid, was investigated against 659 isolates. hr 756 inhibited neisseria and haemophilus species at concentrations similar to those needed with ampicillin. it inhibited beta-lactamase-producing n. gonorrhoeae and h. influenzae. hr 756 was the most active compound tested against members of the enterobacteriaceae, inhibiting most isolates of escherichia coli, klebsiella pneumoniae, proteus mira ... | 1979 | 426518 |
| bl-s786 (ceforanide), a new parenteral cephalosporin: in vitro studies. | bl-s786 (ceforanide) is a new cephalosporin which showed broad-spectrum activity in vitro against 453 clinical isolates. at a concentration of 3.12 mug/ml, it inhibited greater than 75% of isolates of escherichia coli, klebsiella spp., proteus mirabilis, staphylococcus aureus, streptococcus pyogenes, and streptococcus pneumoniae. essentially no activity was observed against isolates of serratia marcescens, and only minimal activity was observed against enterobacter spp. its activity was directly ... | 1979 | 426520 |
| accumulation of udp-glucose pyrophosphorylase by axenically grown amoebae of dictyostelium discoideum. | amoebae of the slime mould dictyostelium discoideum ax2 possess only low udp-glucose pyrophosphorylase activity when grown on autoclaved klebsiella aerogenes (approx. 30 units/mg of protein), but accumulate the enzyme to approx. 150-200 units/mg of protein during vegetative growth in axenic medium. the vegetative accumulation of udp-glucose pyrophosphorylase by axenically grown cells is prevented if autoclaved k. aerogenes are included in the axenic medium, suggesting the absence of a specific i ... | 1979 | 426770 |
| structural studies of the capsular polysaccharide of klebsiella type 33. | the structure of the capsular polysaccharide from klebsiella type 33 has been investigated. methylation analysis, various specific degradations, graded hydrolysis with acid, and n.m.r. spectroscopy were the principal methods used. it is concluded that the polysaccharide is composed of pentasaccharide repeating-units having the following structure. (formula, see manual). the d-galactopyranosyl group, with pyruvic acid linked as a ketal to o-3 and o-4, was degraded on treatment of the fully methyl ... | 1979 | 427835 |
| [microbian contamination of the blood side of the haemodialysis membrane (author's transl)]. | 1979 | 427857 | |
| [the biliary excretion of azlocillin]. | the excretion of azlocillin into the human biliary tract was investigated in 8 patients with a t-tube in the common bile duct after intravenous injection of 2 g. samples of serum and common duct bile were assayed from 15 min to 12 hours after injection. biliary tract levels generally run parallel to serum levels but were about 15 times higher than those. peak levels in t-tube bile averaged 1137 mg/l 60 to 90 min after administration. 12 hours after administration there were still mean concentrat ... | 1979 | 428879 |
| nosocomial klebsiellas. i. colonization of hospitalized patients. | the colonization of patients by klebsiella and several other gram-negative bacteria was studied in a hospital urological ward over a period of six months. before and during the survey there was no evidence of an outbreak of nosocomial infection and multi-drug resistant strains of klebsiella were not isolated. klebsiella were biotyped by nine biochemical tests, which led to the detection of 66 biotypes spread uniformly throughout the survey period. this method of biotyping proved a useful epidemi ... | 1979 | 429785 |
| nosocomial klebsiellas. ii. transfer in a hospital ward. | during a 6-month period an epidemiological survey of the carriage of klebsiella was conducted in a hospital ward where no outbreak of nosocomial infection occurred. in this endemic situation the regular sampling of several sites of patients, members of the nursing staff, and the environment, and the biotyping of klebsiella made it possible to analyse the patterns of transmission between sites. there was abundant evidence for striking transmission of klebsiella between the throat, hands, and faec ... | 1979 | 429786 |
| [the study of terminal infection of malignant disease (author's transl)]. | 1979 | 430885 | |
| a randomized comparative trial of three aminoglycosides--comparison of continuous infusions of gentamicin, amikacin and sisomicin combined with carbenicillin in the treatment of infections in neutropenic patients with malignancies. | continuous infusions of gentamicin, amikacin or sisomicin combined with carbenicillin were compared in a randomized study in the treatment of 572 febrile episodes in 281 patients with cancer. the three treatments (c+a, c+a and c+s) were equally effective with no significant differences in response rate overall (67%, 68%, 67%) or in any infection, except septicemia where c+g had a significantly lower response rate than the other two groups. pneumonia, the most common infection, had the lowest res ... | 1979 | 431401 |
| [characteristics of the antibiotic sensitivity of nitrofuran--resistant gram-negative bacteria of clinical origin]. | 494 persons with various purulent inflammatory diseases were examined. gram-negative nitrofuran resistant organisms isolated from the clinical material were found in 22.9 per cent of the cases. representatives of enterobacteriaceae, klebsiella-enterobacter-serratia (26.8 per cent), proteus-providencia (16.8 per cent) and e. coli-arizona-citrobacter (16.1 per cent) predominated. pseudomonas (32.1 per cent) and acinetobacter (5.3 per cent) predominated among the aerobic gram-negative bacteria. sen ... | 1979 | 434799 |
| klebsiella, spondylitis, and uveitis. | 1979 | 435851 | |
| [in vitro testing of newer cephalosporins (author's transl)]. | the spectrum of activity of the newer cephalosporins is considerably wider and includes a number of gram-negative bacteria. test results using cephalothin as 'class disc' of a class of antibiotics is therefore no longer valid for the newer members. like cefazoline, all of the above-mentioned antibiotics are more effective against escherichia coli. cefuroxin and cefoxitin also display increased effectiveness against klebsiella, as do cefoxitin against serratia and indolpositive proteus species, a ... | 1979 | 437897 |
| [laboratory and clinical studies cs-1170 (author's transl)]. | cs-1170 is a new antibiotic, a derivative of cephamycin c. in vitro, 50 strains of e. coli and klebsiella consisting of gentamicin-sensitive isolated from the blood and gentamicin-resistant strains isolated from the urine were inhibited at concentrations from 0.4 to 12.5 mcg/ml of cs-1170, whereas only 2 strain of klebsiella isolated from the blood had mic more than 50 mcg/ml of the antibiotic. moreover, cs-1170 was significantly more effective than cefazolin and cephalothin against these strain ... | 1979 | 439400 |
| [acute paraproctitis caused by klebsiella]. | 1979 | 439637 | |
| case records of the massachusetts general hospital. weekly clinicopathological exercises. case 25-1979. | 1979 | 440392 | |
| association of respiratory tract colonization with adherence of gram-negative bacilli to epithelial cells. | factors that promote oropharyngeal colonization of seriously ill patients with gram-negative bacilli are as yet poorly understood. in this investigation, 34 subjects who required intensive care were studied; 18 (53%) were colonized with gram-negative bacilli. oropharyngeal epithelial cells of all colonized patients contained adherent bacilli. fewer alpha-hemolytic streptococci but greater numbers of pseudomonas aeruginosa and klebsiella pneumoniae (p less than or equal to 0.01) adhered in vitro ... | 1979 | 448193 |
| a ten-year retrospective study of sepsis in severely burned patients treated with or without silver sulfadiazinate. | three groups of extensive burn patients of the surgical intensive care unit (icu) have been compared: group i: twenty patients, who were treated locally without silver sulfadiazinate (1968-1970); group ii: the twenty first patients topically treated with silver sulfadiazinate (1970-1972); group iii: twenty similarly treated patients, with silver sulfadiazinate, six years later (1976-1977). the groups are statistically comparable. all bacteriological samples were computerized; the chi-square meth ... | 1979 | 451485 |
| septicemia during antibiotic therapy in neutropenic patients. | two patients with acute leukemia developed septicemia while receiving antibiotic therapy. in both cases, the microorganism grown from the blood was sensitive to the drugs the patients were receiving. areas of colonization by the same organisms were found at autopsy in the necrotic spleen and in the necrotic colonic mucosa. septicemia developing during antibiotic therapy can indicate colonization of necrotic organs and appropriate diagnostic and therapeutic measures may be necessary. | 1979 | 451708 |
| [short-term oral chemoprophylaxis before intestine surgery. quantitative determination of bacteria and fungi in stool specimens (author's transl)]. | the methods of quantitative analysis of aerobe and anaerobe microbes and fungi stool specimens are described. the results of the studies in health people are compared to the results in patients undergoing surgical treatment of intestinal tract. a group of these patients received neomycin and bacitracin orally as short-time chemoprophylaxis to diminish possible woundinfection and/or sepsis. after oral medication germs as bifidobacterium, bacteroides and clostridium (not cl. perfringens) are reduc ... | 1979 | 452770 |
| prolonged intraaortic balloon pumping in klebsiella-induced hypodynamic shock: cardiopulmonary, hematological, metabolic, and pathological observations. | 1979 | 454049 |