Publications

vaccines to emerging viruses: nipah and hendra.	hendra virus (hev) and nipah virus (niv) are bat-borne zoonotic para-myxoviruses identified in the mid- to late 1990s in outbreaks of severe disease in livestock and people in australia and malaysia, respectively. hev repeatedly re-emerges in australia while niv continues to cause outbreaks in south asia (bangladesh and india), and these viruses have remained transboundary threats. in people and several mammalian species, hev and niv infections present as a severe systemic and often fatal neurol ...	2020	32991264
coronavirus and other airborne agents with pandemic potential.	the recent emergence of a novel coronavirus (severe acute respiratory syndrome coronavirus 2) has caused a pandemic, which is the most severe infectious disease outbreak in many decades. other infective agents such as influenza as well as other neglected viruses such as lassa virus, nipah virus or poxviruses are also a cause for concern owing to their attack rate and potential for global spread. drug-resistant bacteria, such as mycobacterium tuberculosis, are already a significant public health ...	2020	32995685
understanding the community perceptions and knowledge of bats and transmission of nipah virus in bangladesh.	bats are known reservoirs of nipah virus (niv) and some filoviruses and also appear likely to harbor the evolutionary progenitors of severe acute respiratory syndrome coronavirus (sars-cov), severe acute respiratory syndrome coronavirus-2 (sars-cov-2), and middle east respiratory syndrome coronavirus (mers-cov). while bats are considered a reservoir of deadly viruses, little is known about people's knowledge, attitudes, and perceptions of bat conservation and ecology. the current study aimed to ...	2020	33028047
effective inactivation of nipah virus in serum samples for safe processing in low-containment laboratories.	nipah virus (niv) is an emerging zoonotic paramyxovirus that causes severe encephalitis and respiratory disease with a high mortality rate in humans. during large outbreaks of the viral disease, serological testing of serum samples could be a useful diagnostic tool, which could provide information on not only the diagnosis of niv disease but also the history of an individual with previous exposure to the virus, thereby supporting disease control. therefore, an efficient method for the inactivati ...	2020	33036623
micro-fusion inhibition tests: quantifying antibody neutralization of virus-mediated cell-cell fusion.	although enveloped viruses canonically mediate particle entry through virus-cell fusion, certain viruses can spread by cell-cell fusion, brought about by receptor engagement and triggering of membrane-bound, viral-encoded fusion proteins on the surface of cells. the formation of pathogenic syncytia or multinucleated cells is seen in vivo, but their contribution to viral pathogenesis is poorly understood. for the negative-strand paramyxoviruses respiratory syncytial virus (rsv) and nipah virus (n ...	2020	33054904
prediction of the binding interface between monoclonal antibody m102.4 and nipah attachment glycoprotein using structure-guided alanine scanning and computational docking.	nipah virus (niv) has been designated as a priority disease with an urgent need for therapeutic development by world health organization. the monoclonal antibody m102.4 binds to the immunodominant niv receptor-binding glycoprotein (gp), and potently neutralizes niv, indicating its potential as a therapeutic agent. although the co-crystal structure of m102.3, an m102.4 derivative, in complex with the gp of the related hendra virus (hev) has been solved, the structural interaction between m102.4 a ...	2020	33106487
genetic diversity of nipah virus in bangladesh.	nipah virus (niv) infection, often fatal in humans, is primarily transmitted in bangladesh through consumption of date palm sap contaminated by pteropus bats. person to person transmission is also common and increases the concern of large outbreaks. this study aimed to characterize the molecular epidemiology, phylogenetic relationship, and evolution of the nucleocapsid gene (n gene) of niv.	2020	33129964
nipah virus dynamics in bats and implications for spillover to humans.	nipah virus (niv) is an emerging bat-borne zoonotic virus that causes near-annual outbreaks of fatal encephalitis in south asia-one of the most populous regions on earth. in bangladesh, infection occurs when people drink date-palm sap contaminated with bat excreta. outbreaks are sporadic, and the influence of viral dynamics in bats on their temporal and spatial distribution is poorly understood. we analyzed data on host ecology, molecular epidemiology, serological dynamics, and viral genetics to ...	2020	33139552