Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| experimental study of vaccines against salmonella typhimurium infection. | serological and protective activities of vaccines from s. typhimurium and s. minnesota were studied. it has been demonstrated that active protection against infection in experimental salmonellosis in mice can only be obtained by immunization of the animals using vaccines from complete antigenic complexes isolated from s-strains. it has been found that expressed anti-infection immunity (unlike anti-endotoxic immunity) is induced to the same extent by either high-molecular components (2,000,000 da ... | 1979 | 393775 |
| cysteine auxotrophs of salmonella typhimurium which grow without cysteine in a hydrogen/carbon dioxide atmosphere. | cysteine auxotrophs of salmonella typhimurium mutated in cysb, cysi or cysj grew with sulphate as a sulphur source when incubated under a hydrogen/carbon dioxide atmosphere. yields obtained under these conditions were equivalent to those characteristic of wild-type s. typhimurium. the same mutants failed to grow with sulphate as a sulphur source when incubated aerobically. auxotrophs mutated in cysa, cysc, cysd, cyse, cysg and cysh required cysteine for growth under both incubation conditions. t ... | 1979 | 393803 |
| mutagenicity of halogenated and oxygenated three-carbon compounds. | four structurally related three-carbon compounds, known for their antifertility activity in the male, and the brominated derivatives of two of these compounds were tested for mutagenic activity by the salmonella typhimurium test of ames et al. in the presence of strain ta-100, a base-pair substituion detector strain, 1,2-dibromo-3-chloropropane (dbcp), was the most active compound tested but required enzymatic conversion by 59 microsomal preparation to an active mutagen. three of these compounds ... | 1979 | 393836 |
| plasmid r1 in salmonella typhimurium: molecular instability and gene dosage effects. | 1979 | 394174 | |
| [biological characteristics of salmonella typhimurium cultures isolated from children with nosocomially spread infection]. | 1978 | 394403 | |
| indigenous bacteria influence the number of salmonella typhimurium in the ileum of gnotobiotic mice. | gnotobiotic balb/c mice associated with indigenous lactobacillus, bacteroides, and two fusiform-shaped clostridium strains had fewer s. typhimurium present in the ileum 3 days after intragastric challenge with the pathogen than did similarly challenged germfree mice. acetic and butyric acids were detected in the caecal contents of the gnotobiotic mice, but in smaller concentration than was present in conventionalized mice. no difference in the motility of the small intestine was detected between ... | 1979 | 394821 |
| carcinogenicity and mutagenicity of 4-nitropyridine 1-oxide derivatives. | carcinogenicity and mutagenicity of 4-nitropyridine 1-oxide (4-npo) and 7 kinds of its alkyl derivatives were tested on mice and on salmonella typhimurium strains and escherichia coli strains. 3-methyl-4-npo is the most potent carcinogen, followed by 3-ethyl-4-npo and then 4-npo. mutagenicity was most potent in 3-methyl, 2,3-dimethyl, and 2,5-dimethyl derivatives, moderate in 4-npo and 2-methyl and 2,6-dimethyl derivatives, and to a least extent in 3,5-dimethyl-4-npo. structure-mutagenicity rela ... | 1979 | 395009 |
| genetic organization of the salmonella typhimurium ilv gene cluster. | a number of salmonella typhimurium ilv::tn10 insertion strains were used to analyze the salmonella ilv gene cluster. tn10 generated ilv deletion mutants were employed in mapping experiments to conclusively define the gene order as ilvg-e-d-a-c. examination of ilv enzyme levels confirms that the direction of transcription of ilvgeda is from ilvg to ilva. the major control locus, designated ilvo, is located before ilvg forming an ilvogeda transcriptional unit that is multivalently repressed by iso ... | 1979 | 395408 |
| formate dehydrogenase mutants of salmonella typhimurium: a new medium for their isolation and new mutant classes. | we have designed a new medium for the differentiation of mutants of salmonella typhimurium defective in the ability to reduce nitrate with formate, and have characterized 24 formate dehydrogenase (fdh) mutants isolated on this medium. the mutants were assayed for the ability to use formate to reduce benzyl viologen and phenazine methosulfate, and were mapped by means of conjugation and p22-mediated transduction. mutants lacking the ability to reduce either dye were found to map at three distinct ... | 1979 | 395418 |
| [mutagenic and carcinogenic actions of some polycyclic aromatic hydrocarbons]. | the carcinogenic and mutagenic actions of benz(a)pyrene (bp) and its derivatives 6-methyl-, 6-formyl-, 6-chloro-, 6-hydroxy-, 6-acetoxy-, 6-methoxy- and 4(5)-methoxy-bp were studied in mice and bacteria salmonella typhimurium ta-98 and ta-100, respectively. the potent carcinogenic agents bp, 6-methyl-, 6-formyl-bp proved also mutagenic in bacteria of both strains. weak carcinogenic compounds (6-chloro-, 6-methoxy-, 4(5)-methoxy-bp) and noncarcinogenic ones (6-acetoxy-, 6-hydroxy-bp) either turne ... | 1979 | 395973 |
| the effect of protein modification reagents on the chemotactic response in salmonella typhimurium. | several classes of reagents that covalently modify proteins have been shown to inhibit the ability of salmonella typhimurium to reverse the direction of its flagellar rotation. such reversal normally allows the bacterium to tumble and reorient its movement in a more favorable direction. these reagents include those that react with amino, guanidino, sulfhydryl, and disulfide groups on proteins. at high concentrations, most of these compounds also cause the paralysis of flagellar rotation. tumblin ... | 1979 | 396013 |
| methionine transport in salmonella typhimurium: evidence for at least one low-affinity transport system. | the systems which transport methionine in salmonella typhimurium lt2 have been studied. fourteen mutants, isolated by three different selection procedures, had similar growth characteristics and defects in the specific transport process showing a km of 0.3 microm for l-methionine, and therefore lack the high-affinity, metp transport system. the sites of mutation in four of the mutants were shown by p1-mediated transduction to be linked (0.3 to 1.1%) with a proline marker located at unit 7 on the ... | 1979 | 396352 |
| regulation of late functions in salmonella bacteriophages p22 and l studied by assaying endolysin synthesis. | the rate of endolysin synthesis in salmonella typhimurium cells infected by bacteriophage p22 or l was taken as a measure for the activity of 23 gene product (the positive regulator for the "late" genes of p22 and l). endolysin in coded for by gene 19. the amber mutations in gene 23 of p22 and l, used in this study, reduced the rate of endolysin synthesis by a factor of ca. 90 for p22 and of ca. 20 for l. in mixed infections with 19- and 23- mutants the 23 gene products of p22 and l act as posit ... | 1979 | 396381 |
| is the injection of dna enough to cause bacteriophage p22-induced changes in the cellular transport process of salmonella typhimurium? | it was demonstrated earlier in this laboratory that phage p22 induces a transient depression in the cellular transport processes of the host salmonella typhimurium immediately after infection and that an effective injection process is enough to cause the depression. by using defective phage particles that contain host dna instead of phage dna for infection, it has been demonstrated that the injection of phage-specific dna is essential for this. the defective particles adsorbed to the host and in ... | 1979 | 396382 |
| effects of subminimal inhibitory concentrations of antibiotics in experimental infections. | the antibacterial effects of subminimal inhibitory concentrations (sub-mics) of antibiotics were studied in two animal models. in mice, the oral cephalosporin cgp 9000 was effective in 11 of 20 different gram-negative infections and cephalexin was effective in one of these infections, both at 50% effective doses (ed(50)) that produced peak concentrations of drug in plasms equal to one-half to one-sixteenth the minimal inhibitory concentration (mic) for the infecting organism. in gram-positive in ... | 1979 | 396639 |
| effect of weak-, non-, and co-carcinogenic chemicals on 2-acetylaminofluorene-induced mutation in salmonella typhimurium. | the effects of various weak, non-, and co-carcinogenic chemicals on 2-acetylaminofluorene-induced mutation in salmonella typhimurium were studied. we found that a single co-mutagen could provide for either enhanced or decreased mutagenesis. a differential effect on mutagenic expression was dependent upon: (1) the type of inducer of s-9 (supernatant from liver homogenate centrifuged at 9000 x g) liver enzymes; (2) the amount of s-9 enzyme preparation employed; and (3) the combined dose of mutagen ... | 1979 | 396694 |
| mutagenicity of 5,6-dimethoxysterigmatocystin, a metabolite from aspergillus multicolor, in the salmonella/microsome system. | the natural sterigmatocystin derivative, 5,6-dimethoxysterigmatocystin, was found to be a mutagen for salmonella typhimurium strains ta98 and ta100 after metabolic activation in a mammalian microsome system. | 1979 | 396882 |
| in vitro drug resistance of salmonellae in singapore. | strains of salmonella typhi isolated in singapore were susceptible to chloramphenicol (except from two imported cases) and most of them also generally susceptible to ampicillin and septrin. drug-resistant strains of salmonella typhimurium appeared in 1971 and caused out-breaks among young children. however, decreasing drug-resistance of s. typhimurium was recorded in recent years following a drop in the number of cases. other salmonella serovers were found relatively susceptible to the antibioti ... | 1979 | 396915 |
| effect of environmental temperature on susceptibility of young chickens to salmonella typhimurium. | day-old chickens kept in a cold environment (18 degrees to 22 degrees c) were more susceptible to a low and moderate challenge of salmonella typhimurium than chickens similarly challenged and kept in a warm environment (32 degrees to 36 degrees c). cold stress at 10 degrees c for 24 h when applied to 12-day-old chickens effectively increased the number of birds shedding organisms. however a similar cold stress on 20-day-old chickens resulted in a less dramatic increase in the number of birds she ... | 1979 | 396919 |
| differential effect of a microsomal deacetylase inhibition on the mutagenicity in salmonella typhimurium of 2-acetylaminofluorene by liver homogenates of guinea pigs, mice and rats. | the effect of paraoxon, a microsomal deacetylase inhibitor, on the mutant genicity of 2-acetylaminofluorene (aaf) by liver homogenates was compared between the aaf carcinogenesis-resistant guinea pigs and the susceptible mice and rats. the mutagenicity of aaf was mostly abolished by paraoxon, not only in the 3 kinds of untreated animals but also in guinea pigs treated with a combination of phenobarbital and 5,6-benzoflavone, whereas about 50% of the mutagenicity was resistant to paraoxon in trea ... | 1979 | 396979 |
| lack of microbial genetic response to 2.45-ghz cw and 8.5- to 9.6-ghz pulsed microwaves. | strain d4 of the yeast saccharomyces cerevisiae, and strains ta-1535, ta-100 and ta-98 of the bacterium salmonella typhimurium, were exposed to 2.45-ghz continuous wave or 8.5- to 9.6-ghz pulsed electromagnetic radiation (emr) at various power densities from 1 to 45 mw/cm2. the temperature during radiation was maintained at 30 degrees c for yeast cultures and at 37 degrees c for bacterial cultures. the studies revealed no increase in mutations or of mitotic gene conversions when cells were radia ... | 1979 | 397346 |
| [determination of the sensitivity of 55 strains of salmonella typhimurium to 13 antibiotics using the minimal inhibitory concentration and plaque diffusion methods]. | 1979 | 397549 | |
| factors influencing the copy number of f-like plasmids in escherichia coli and salmonella typhimurium. | the copy numbers of flac, four f-like plasmids and plt2 were estimated in two strains of salmonella typhimurium and (for all except plt2) one strain of escherichia coli. for organisms grown in casamino acids minimal medium, the plasmids spanned a 7--8 fold range of copy number with colb-k98 having the highest copy number in each strain and r124 the lowest. the copy number of colb-k98 was substantially greater than 1 in each of the strains tested. there was no clear relation between the plasmid s ... | 1979 | 397682 |
| cross-protection aginst salmonella enteritidis infection in mice. i. immunization trials. | mice were immunized subcutaneously with live and killed vaccines, with and without complete adjuvant incorporating salmonella typhi-murium m206, salmonella gallinarum 9r, salmonella pullorum sp223 as well as homologous salmonella enteritidis se795. the animals were challenged 21 days post-vaccination with 100 ld50 of virulent s. enteritidis 5694 smr subcutaneously along with unvaccinated control mice. to assess the immunity against acute and chronic infections, the percentage of absolute survivo ... | 1979 | 397731 |
| cross-protection against salmonella enteritidis infection in mice. | mice were immunized subcutaneously with live vaccines and live vaccines with complete adjuvant incorporating salmonella enteritidis se 795, salmonella typhi-murium m206, salmonella gallinarum 9r or salmonella pullorum sp223. they were challenged along with unvaccinated controls with 100 ld50 of virulent s. enteritidis 5694 smr subcutaneously on the 21st day post-vaccination. the humoral immune response was studied by assessing the sequential level of agglutinins, complete and incomplete somatic ... | 1979 | 397732 |
| cross-protection against salmonella enteritidis infection in mice. iii. delayed hypersensitivity reaction and clearance of the challenge organism. | mice were immunized with live vaccines and with live vaccines with complete adjuvant incorporating salmonella enteritidis, salmonella typhi-murium, salmonella gallinarum or salmonella pullorum. on the 21st day after vacination, the hypersensitivity reactions elicited by the mice to extracts of the challenge organism (s. enteritidis 5694 smr) were assessed. the degree of delayed hypersensitivity reaction was compared with the level of protection induced by the vaccine. the role in protection of d ... | 1979 | 397733 |
| combined effect of intercalating agents and antibiotics on r-factor carrying bacteria in broth culture. | growth of salmonella typhimurium lt2 and escherichia coli k12 bearing any of four r-factors of the fi+ and fi- group in repressed and derepressed form was not inhibited by a combination of ethidium bromide with ampicillin and kanamycin. | 1979 | 397935 |
| [effect of d,l-ureidosuccinic dihydrazide on the biological properties of pseudomonas pseudomallei and salmonella typhimurium]. | 1979 | 398137 | |
| mutagenic effect of 1.1'-hexamethylene-bis-[(5-p-chlorophenyl)-biguanide]. | the strongly effective bactericidal compound 1.1'-hexamethylene-bis-[(5-p-chlorophenyl)-biguanide] (hcg) induces mutations with a slight inactivation rate in the auxotrophic strains salmonella typhimurium ta 1535 and ta 1538 in 0.4 microm solution. the mutagenic effect could be confirmed by using the plate incorporation test and the repair test. as phenylethylbiguanide at different inactivation rates does not show any mutagenic effect, the biguanide structure does not seem to be responsible for ... | 1979 | 398749 |
| synthesis of l-cysteine in salmonella typhimurium. | in salmonella typhimurium and escherichia coli the biosynthesis of l-cysteine from l-serine and inorganic sulphate proceeds along a branched convergent pathway along one arm of which sulphate is reduced to sulphide, while on the other l-serine is acetylated to o-acetyl-l-serine. this system is subject to positive genetic control in which growth on a poor sulphur source, o-acetyl-l-serine and the product of the cysb regulatory gene are all required for derepression. the final step consists of the ... | 1979 | 398768 |
| reduction of mutagenic activity of aflatoxins after uv-irradiation. | solutions of aflatoxins b1, b2, g1 and g2 and solid films of aflatoxin b1 were irradiated with uv light of wavelength corresponding to the absorption band of aflatoxins at approximately 365 nm (approximately 27 500 cm-1). the reaction was followed spectrophotometrically. simultaneously the mutagenicity of samples of aflatoxins was determined using salmonella typhimurium/mammalian microsome test. uv-irradiation caused a modification in all aflatoxins studied (in aqueous and nonaqueous solutions a ... | 1979 | 399142 |
| the role of l-proline in response to osmotic stress in salmonella typhimurium: selection of mutants with increased osmotolerance as strains which over-produce l-proline. | 1979 | 399184 | |
| colonization by salmonella typhimurium and shigella flexneri iii of the gastrointestinal tract of mice treated with beta-2-thienylalanine and streptomycin. | mice fed beta-2-thienylalanine (beta-2-t) by oesophageal tube were no more susceptible to gastrointestinal tract colonization by salmonella typhimurium or shigella flexneri iii than control mice fed water. in both beta-2-t-fed and water-fed groups, the increasing dosage of s. typhimurium, in logarithmic increments to groups of mice, resulted in increasing numbers of these bacteria detectable on dilution plates from organ homogenates. colonization by s. flexneri iii only occurred at a dosage of 1 ... | 1979 | 399720 |
| effect of the co-carcinogen benzo[e]pyrene on microsome-mediated chemical mutagenesis in salmonella typhimurium. | chemical agents that possess the ability to alter tumorigenicity of carcinogens (administered at subthreshold dose) constitute a major health hazard. we have employed the ames salmonella assay to examine the effect of co-carcinogenic benzo[e]pyrene (b[e]p) on microsome-mediated chemical mutagenesis. b[e]p enhanced the mutagenic activity induced by 2-acetylaminofluorene (2-aaf) and benzo[a]pyrene (b[a]p) in strains ta1538 and ta98. enhancement was also noted with n-hydroxy-2-aaf (the proximal met ... | 1979 | 399907 |
| bile as a source of mutagenic metabolites produced in vivo and detected by salmonella typhimurium. | the in vivo metabolic activation of several mutagenic compounds was assayed in the bile of rats, with salmonella typhimurium as the indicator organism. it was determined that for some compounds, particularly the aromatic amines, a substantial percentage of the compound was excreted into the bile as either a nonmutagenic glucuronide conjugate or a mutagenic metabolite of the compound. relatively low doses of the chemical were detected, and it was possible to follow the excretion pattern of the co ... | 1979 | 399910 |
| mutagenicity detection of in vivo nitrosation of dimethylamine by nitrite. | in vivo nitrosation of dimethylamine by nitrite was measured with an intrahepatic host-mediated mutagenicity assay using salmonella typhimurium as the detecting organism. it was possible to detect the product, n-nitrosodimethylamine, at much lower doses with this system than with previously reported in vivo systems. this and other improvements made it possible to detect the formation of nitrosodimethylamine from relatively low levels of gavaged precursors. | 1979 | 399911 |
| mutagenic evaluation of nitroparaffins in the salmonella typhimurium/mammalian-microsome test and the micronucleus test. | three nitroparaffins (nitroethane, 1-nitropropane, and 2-nitropropane) were studied in the salmonella typhimurium/mammalian microsome (ames) test, with and without microsomal activation systems. nitroethane and 2-nitropropane also were studied in an in vivo mutagenic (micronucleus) test. these studies were undertaken because these solvents are widely used in the chemical and pharmaceutical industries and 2-nitropropane was reported to cause liver cancer in rats exposed by the inhalation route. n ... | 1979 | 399919 |
| [a salmonella typhimurium epidemic in premature and newborn infants (author's transl)]. | salmonella typhimurium was isolated from a fatal epidemic among premature and newborn infants in the children's hospital of hacettepe university. the epidemic showed gastroenteritis, sepsis and meningitis. salmonella typhimurium were isolated from 17 of 65 infants. no salmonellae were isolated from the personnel of the unit and from the personnel of the related kitchen. the mothers could not be examined. examinations are being continued with the collaboration of the said unit and a more detailed ... | 1979 | 399993 |
| [salmonella typhimurium isolated from a burn wound]. | salmonella typhimurium isolated from a burn wound, in burn unit of hacattepe university hospital, general surgery department. | 1979 | 400299 |
| [edwardsiellae tarda and sp., and salmonella typhimurium from birds in camargue]. | 1979 | 400399 | |
| suppression of the dnaa phenotype by mutations in the rpob cistron of ribonucleic acid polymerase in salmonella typhimurium and escherichia coli. | a class of mutations that confer resistance to rifampin in salmonella typhimurium and escherichia coli also suppresses the thermosensitivity of chromosome initiation in dnaa mutants. ribonucleic acid polymerase is resistant to rifampin in vitro in these suppressive mutants, and the suppressors of dnaa cannot be separated from the rpob mutations by transduction. it is concluded, therefore, that certain rpob mutations may suppress the dnaa phenotype. | 1977 | 400782 |
| influence on motility of escherichia coli and salmonella typhimurium by a naturally occurring conjugative plasmid. | in a collection of 45 r-plasmids, one was found to be associated with loss of motility of its escherichia coli k-12 and salmonella typhimurium host bacteria when tested in conventional motility agar. genetic experiments, as well as analyses of deoxyribonucleic acid, showed that inhibition of motility was caused by a conjugative plasmid that was separate from the r-plasmid. this second plasmid, named pum5, was fi- and mediated the same type of sex pilus (f-like) as the accompanying r-plasmid but ... | 1977 | 400783 |
| biosynthesis of bacterial glycogen: genetic and allosteric regulation of glycogen biosynthesis in salmonella typhimurium lt-2. | structural gene mutants of the glycogen biosynthetic enzymes adenosine diphosphate glucose pyrophosphorylase (glgc) and glycogen synthase (glga) were isolated and partially characterized. the cotransduction frequencies of these genes with the aspartic semialdehyde dehydrogenase (asd) and glycerol-3-phosphate dehydrogenase (glpd) genes suggested the unambiguous gene order of glpd glga glgc asd. the results of the three-factor cross glpd- glga- glgc+ x glpd+ glga+ glgc- were consistent with the pr ... | 1977 | 401493 |
| r plasmids coding for gentamicin, tobramycin, and carbenicillin resistance in serratia, klebsiella and escherichia coli strains from a single clinical source. | serratia marcescens, klebsiella sp. and escherichia coli strains bearing transferable resistance to aminoglycoside antibiotics, namely, gentamicin, tobramycin, kanamycin, streptomycin, lividomycin, and carbenicillin, as well as to a series of more classical drugs, began to emerge in materials from the frankfurt university hospital. plasmids from serratia, klebsiella, and e. coli exhibit a broad host range in that they are transferable to e. coli, proteus mirabilis and salmonella typhimurium rece ... | 1977 | 401718 |
| immunochemical comparison of phosphoribosylanthranilate isomerase-indoleglycerol phosphate synthetase among the enterobacteriaceae. | the bifunctional enzyme of the tryptophan operon, phosphoribosylanthranilate isomerase-indoleglycerol phosphate synthetase (prai-ingps;ec 4.1.1.48), was characterized by an immunochemical study of six representative members of the enterobacteriaceae: escherichia coli, salmonella typhimurium, enterobacter aerogenes, serratia marcescens, erwinia carotovora, and proteus vulgaris. prai-ingps was purified from e. coli, and antisera were prepared in rabbits. these antisera were utilized in quantitativ ... | 1977 | 403178 |
| mitogenic activity of cell wall components from smooth and rough strains of brucella abortus. | on the basis of [3h]thymidine incorporation by normal mouse spleen cell cultures, cell wall preparations from a smooth (45/0) strain and a rough (45/20) strain of brucella abortus were strongly mitogenic. on the other hand, none of several subcomponents extracted from the cell wall preparations, including aqueous and phenolic lipopolysaccharides, was active. these results contrast with the marked mitogenic activity of lipopolysaccharides isolated from other gram-negative bacteria such as salmone ... | 1977 | 404248 |
| responsiveness of rabbit spleen and appendix cells to bacterial mitogens. | rabbit spleen and appendix cells were used to test the mitogenic activity of a commercial lipopolysaccharide (lps) preparation from salmonella typhimurium (difco), a preparation extracted from it, and cell wall preparations from smooth (45/0) and rough (45/20) strains of brucella abortus. on the basis of [3h]thymidine incorporation ratios (e/c), that is, the incorporation rate among cells treated with the mitogen relative to that of untreated cells, the extracted lps and both brucella cell wall ... | 1977 | 405322 |
| binding of progesterone to neisseria gonorrhoeae and other gram-negative bacteria. | the binding of [1,2-(3)h]progesterone to progesterone-sensitive neisseria gonorrhoeae cs-7 and the progesterone-insensitive neisseria mucosa, pseudomonas aeruginosa, and salmonella typhimurium (rough and smooth strains) was investigated. the kinetics of binding to n. gonorrhoeae cs-7 demonstrated that the majority of the progesterone binding occurred and equilibrium was reached within the first 30 min. despite the rapid binding of progesterone, only about 20% of the added steroid was bound at th ... | 1977 | 406199 |
| mutagenicities of n-nitrosamines on salmonella. | the mutagenic activities of 11 n-nitrosamines were tested using salmonella typhimurium ta100 and ta98. all the carcinogenic n-nitrosamines were mutagenic on ta100 with a drug-activating system from the rat liver, whereas n,n-diphenylnitrosamine, a non-carcinogen, was not mutagenic. none of the n-nitrosamines was mutagenic on ta98, except n,n-diethylnitrosamine which was weakly mutagenic. to detect the mutagenicity of n,n-dimethylnitrosamine, the pre-incubation of bacteria and n,n-dimethylnitrosa ... | 1977 | 406555 |
| methyl bromide as a microbicidal fumigant for tree nuts. | methyl bromide (mebr) has broad microbicidal activity, but its use as a disinfectant for food is limited by the resulting bromide residues. increasing the mebr concentration, exposure temperature, or exposure period of a treatment tended to increase both the microbicidal efficacy of mebr and the bromide residues. its sporicidal activity was less at high than at low relative humidity within the range of 20 to 99%. both the efficacy and the resulting residues of a mebr treatment varied inversely w ... | 1977 | 406844 |
| comparative studies of rna polymerase subunits from various bacteria. | the molecular structure of rna polymerases from escherichia coli, salmonella typhimurium, salmonella anatum,serratia marcescens, aerobacter aerogens, proteus mirabilis and bacillus subtilis were compared based on:i) inhibition of the enzyme activity by treatment with antibodies against e. coli rna polymerase subunits;ii) analysis of antibody precipitates by sodium ododecyl sulfatepolyacrylamide gel electrophoresis; and iii) analysis of antibody precipitates by urea-isoelectrofocusing followed by ... | 1977 | 408600 |
| sequential changes in body composition during infection: electron probe study iv. | alterations occur in human muscle electrolyte and water composition in response to infection. there appear to be at least two basic mechanisms; the first is an exchange of sodium for potassium without alteration in water content of muscle. the second is an increase in cellular na and water without a loss of k on a dry weight basis. in a series of studies in monkeys, salmonella typhimurium sepsis was induced as an experimental model. both patterns of muscle response to infection were detected. el ... | 1977 | 409271 |
| absence of mutagenicity of coralyne and related antileukemic agents: structural comparison with the potent carcinogen 7,12-dimethylbenz[a]anthracene. | the structural similarity between antileukemic alkaloid coralyne and the carcinogenic and antineoplastic hydrocarbon 7, 12-dimethylbenz[a]anthracene, as well as the similarity between the antileukemic alkaloid nitidine and the carcinogenic hydrocarbon 5-methylchrysene, prompted a mutagenicity evaluation of coralyne sulfoacetate, nitidine chloride, the 8-ethyl homolog of coralyne, nitidine methosulfate, and the tetramethoxy analog of nitidine by the ames method against the histidine-auxotroph str ... | 1977 | 411911 |
| hyperthermia and human leukocyte functions: effects on response of lymphocytes to mitogen and antigen and bactericidal capacity of monocytes and neutrophils. | it has recently been demonstrated that fever, or hyperthermia, results in enhanced survival of lizards infected by aeromonas hydrophila. in the present study, the effects of hyperthermia on certain immune functions were assayed in vitro with purified human leukocytes. lymphocyte transformation responses to the mitogen phytohemagglutinin and the common antigen streptokinase-streptodornase were enhanced at 38.5 degrees c relative to 37 degrees c whether analyzed according to absolute counts per mi ... | 1977 | 412788 |
| [cellular composition of the lymph nodes of monkeys (rhesus macaque) under normal and experimental conditions]. | by means of mathematical methods, quantitative and qualitative changes were studied in different structural components of the mesenteric (ileocecal) lymph nodes in normal monkeys (macaca rhesus) and under per os administration of salmonella typhi murium, streptomycin-dependent. cellular composition was calculated in the cortical plateau, cortical (lymphoid) cords and in follicules. average percent of every cell type was determined. vaccine administration, was stated to inhibit cytopoiesis in the ... | 1978 | 415703 |
| mutagenicity of the halogenated olefin, 2-bromo-2-chloro-1,1-difluoroethylene, a presumed metabolite of the inhalation anesthetic halothane. | the presumed halothane metabolite, 2-bromo-1,1-difluoroethylene, produces both base substitution and frameshift mutations in salmonella typhimurium. direct mutagenesis of isolated dna also was observed by using a bacillus subtils transformation assay to score the production of mutagenic lesions in transforming dna. | 1977 | 417917 |
| comparison of mutagenicity, antitumor activity, and chemical properties of selected nitrosoureas and nitrosoamides. | a number of nitrosoureas and nitrosoamides have been compared with respect to mutagenicity for salmonella typhimurium, in vitro cytotoxicity, in vivo toxicity and antitumor activity against murine l1210 leukemia, and chemical properties. despite chemical similarities between the nitrosoureas and nitrosoamides, they show important differences in biological activity. some of the nitrosoureas are very active antitumor agents, and they are less mutagenic than are the corresponding nitrosoamides, whi ... | 1979 | 421216 |
| 5-iminodaunorubicin. reduced cardiotoxic properties in an antitumor anthracycline. | treatment of daunorubicin with methanolic ammonia affords 5-iminodaunorubicin, the first quinone-modified analogue of either daunorubicin or adriamycin. this product retains antileukemic activity in mice, is less cardiotoxic by electrocardiographic measurements in rats, and is nonmutagenic in salmonella typhimurium (ames test). | 1979 | 423181 |
| the nature of arginine auxotrophy in cutaneous populations of staphylococci. | l-arginine was required for growth by a high percentage of strains of staphylococcus species that were niche-specific and/or host-specific, but was usually not required for growth by species showing a wide host range. growth stimulation patterns with arginine intermediates indicated that most of the auxotrophic strains had blocks in an early step(s) in arginine biosynthesis. these strains were designated phenotypically as arg(chg) according to the salmonella typhimurium classification scheme. st ... | 1979 | 438776 |
| synthesis of the glucuronic acid conjugate of methylazoxymethanol. | the glucuronic acid conjugate of methylazoxymethanol was synthesized by oxidizing the primary alcohol of the glucose moiety of cycasin (methylazoxymethanol-beta-d-glycopyranoside) to a carboxylic acid. the oxidation was carried out by bubbling oxygen gas through a cycasin solution in the presence of a platinum-on-carbon catalyst. a band at 1715 cm-1, not present in the cycasin infrared spectrum, appeared in the spectrum of the oxidized cycasin product, establishing the presence of a carboxylic a ... | 1979 | 455292 |
| [vaccination against staphylococcal infections in animal experiments]. | based on favour and clinical observations we have undertaken to observe the effect of vaccination against staphylococcic infection in the mouse. a standard amount of staphylococcus was used together with a metal implant. after two weeks in the control group always an infection could be observed, and germs could be cultivated. in the groups with staphypan and in the groups with vaccinated specific vaccinia a less strong infection was observed, while a vaccinia made from salmonella typhimurium and ... | 1979 | 468564 |
| phosphate and heat treatments to control salmonella and reduce spoilage and rancidity on broiler carcasses. | broiler chicken carcasses were inoculated with about 300 cells of a naladixic acid resistant strain of salmonella typhimurium, then treated for 3 min with highly agitated water with or without 6% phosphate added, at 65, 70, 75, 80, 85, or 90 c. other broiler carcasses were inoculated with about 60 cells, then similarly treated at 65 or 70 c. all carcasses were chilled after the hot water treatment in a system simulating commerical chilling. when inoculum was 300 cells, at least 5% of the carcass ... | 1979 | 471881 |
| synergistic effect of diethylstilbestrol on the mutagenicity of 2-acetylaminofluorene and n-hydroxy-acetylaminofluorene in the salmonella assay system. | salmonella typhimurium, ta-1538, was used to investigate the mutagenic potential of n-2-acetylaminofluorene (2-aaf), n-hydroxy-n-2-acetylaminofluorene (n-oh-2-aaf) and diethylstilbestrol (des) individual and in combination. in the presence of an induced or uninduced rat liver metabolizing system (s-9), the histidine requiring strain of bacteria was reverted to prototrophy by the aromatic amines but not by the synthetic estrogen. however, when des was combined with 2-aaf or n-oh-i-aaf in the pres ... | 1979 | 476604 |
| mutagenicity of n-nitroso pyridinol carbamate with the salmonella/mammalian microsome test. | pyridinol carbamate was nitrosated to the n,n1-dinitroso derivative and the structure was proved by spectroscopic methods, including chemical ionization mass spectroscopy. by the ames test, the dinitroso derivative showed a significant dose-dependent mutagenic response with salmonella typhimurium strains ta 1535 and ta 100; the response became more pronounced in the presence of microsomes. as the dosage of n-nitroso pyridinol carbamate increased, the number of revertant colonies also increased. ... | 1979 | 476608 |
| aquarium pets as a source of antibiotic-resistant salmonellae. | thirteen serotypes of salmonella isolated from imported ornamental aquarium frogs, snails, and their waters were shown to be multi-drug-resistant. among the resistances exhibited were resistance to gentamicin, sulfamethoxazole-trimethoprim, cephalothin, and nalidixic acid. frog isolates displayed eight different patterns and snails isolates had two different resistance patterns. the most common serotype, salmonella typhimurium, was resistant to 18 antibacterials while other salmonellae were resi ... | 1979 | 487294 |
| increased production of mutagenic metabolites of carcinogens by tissues from senescent rodents. | activation of the procarcinogens benzo(a)pyrene and 2-fluorenamine by liver homogenates (s9) prepared from senescent male cfn rats and c57bl/6j mice resulted in an enhanced production of mutagenic metabolites when compared to young rodents, as indicated by an enhancement of the induced reversion frequency in a salmonella typhimurium bioassay. similar results were observed when carcinogen activation was mediated by purified hepatic microsomes, indicating that the age-related differences in carcin ... | 1979 | 498103 |
| zoonotic diseases in psittacine birds: apparent increased occurrence of chlamydiosis (psittacosis), salmonellosis, and giardiasis. | between september 1977 and november 1978, chlamydiosis (psittacoisis) was diagnosed in 52 of 128 parrots, 5 of 12 cockatiels, 2 of 5 cockatoos, 3 of 6 macaws, 1 of 22 conures, 2 of 18 lovebirds, and 6 of 76 parakeets; 2 lories and 1 lorikeet were chlamydiosis negative. two cases of human chlamydiosis were associated with two submissions of parrots subsequently found to have active infection. twenty parrots (including 13 that were chlamydiosis positive), 2 cockatiels, 1 macaw, 1 lorie, and 1 para ... | 1979 | 500464 |
| separation and purification of a potent bactericidal/permeability-increasing protein and a closely associated phospholipase a2 from rabbit polymorphonuclear leukocytes. observations on their relationship. | two antibacterial proteins from rabbit polymorphonuclear leukocytes, a potent bactericidal cationic protein that increases the envelope permeability of susceptible gram-negative bacteria and a phospholipase a2, have been purified to near homogeneity by ion exchange, gel filtration, and hydrophobic interaction chromatography. the apparently noncatalytic bactericidal/permeability-increasing protein has an approximate molecular weight of 50,000 and is isoelectric at ph 9.5 to 10.0. the molecular pr ... | 1979 | 500619 |
| biological activity of tobacco smoke and tobacco smoke-related chemicals. | exposure to whole cigarette smoke from reference cigarettes results in the prompt (peak activity is 6 hrs), but fairly weak (similar to 2 fold), induction of murine pulmonary microsomal monooxygenase activity. this activity can be detected by using as substrates either benzo(a)pyrene or ethoxyresorufin, and can be inhibited by treatment with cycloheximide or actinomycin d. unlike the induction of pulmonary monooxygenases following intratracheal administration of 3-methylcholanthrene, these cigar ... | 1979 | 510243 |
| the susceptibility to tryptic hydrolysis of peptide bonds involving epsilon-n-methyllysine. | using isolation of soluble peptides as a means of comparing the efficiency of tryptic hydrolysis of various forms of the phase-1 flagellin of salmonella typhimurium, it was found that peptides terminating in n-methyllysine required a longer period of exposure to enzyme for their detection than did equivalent peptides terminating in lysine. | 1979 | 518920 |
| relationship of carcinogenicity, mutagenicity, and k-region reactivity in benz[c]acridines. | benz[c]acridine and its 10 methyl-substituted derivatives were examined for chemical reactivity with osmium tetroxide and mutagenic activity on salmonella typhimurium, and the results were contrasted with the electronic charge in the k region and the carcinogenic activity of benz[c]acridines. the addition of osmium tetroxide took place at the k region of benz[c]acridines. a linear relationship was established between the charge in the k region and the rate constant of the second-order reaction b ... | 1979 | 535685 |
| [antibacterial kinetics of fosfomycin (author's transl)]. | the authors studied, with the autobac machine, the kinetics of antibacterial activity of fosfomycin against staphylococcus aureus, streptococcus d' streptococcus pneumoniae, neisseria meningitidis, acinetobactor lwoffi, haemophilus influenzae, salmonella typhimurium, escherichia coli, proteus rettgeri, klebsiella pneumoniae, serratia marcescens and pseudomonas aeruginosa. a correlation appears between the kinetics of fosformycin antibacterial action and the microbial growth rate. | 1979 | 547759 |
| [isolation of salmonella from marine shellfish]. | the present paper reports the isolation of salmonella from oysters and clams encountered in the marine waters of santos and destined to the human consumption. the results obtained showed the characterization of 41 (59,43%) strains of salmonella arizonae and 28 (40,57%) of salmonella typhimurium, by its cultural biochemical and serological properties. the drug resistance of salmonella to several antibiotics was also investigated by determining the minimal inhibitory concentration in serial agar p ... | 1979 | 554598 |
| antibiotics from basidiomycetes. v merulidial, a new antibiotic from the basidiomycete merulius tremellosus fr. | merulidial, a new antibiotic, was isolated from the culture fluid of the basidiomycete merulius tremellosus fr., strain no. wq 568. merulidial inhibits a variety of bacteria and fungi. in cells of the ascitic form of ehrlich carcinoma, dna synthesis is inhibited at lower concentration as compared to rna and protein synthesis. merulidial shows mutagenicity when incubated with the his-mutant ta 100 for salmonella typhimurium (b.n.ames). the molecular formula as determined by high resolution mass s ... | 1978 | 567638 |
| mutagenic activation of 2-acetylaminofluorene by guinea-pig liver homogenates: essential involvement of cytochrome p-450 mixed-function oxidases. | 2-acetylaminofluorene (aaf) was highly mutagenic to salmonella typhimurium strain ta98, when activated by a liver post-mitochondrial supernatant fraction (s9 fraction) from guinea-pigs, in spite of the resistance of this species to aaf carcinogenesis and the low capacity of the liver of this species for n-hydroxylation of aaf. the mutagenicity was comparable to or higher than that resulting from activation by mouse- or rat-liver s9 fraction, and was not enchanced by treatment with cytochrome p-4 ... | 1979 | 574615 |
| [structure of the salmonella from animals, birds and the environment through the period of 1970-1975]. | studied were biochemically and serologically the species of a total of 8738 salmonella cultures. most of the investigated strains belonged to subgenus i--95 species; to subgenus ii belonged one species (salmonella sofia); to subgenus iii belonged 4 species: salmonella arizonae 11:b:1, 7; salmonella arizonae 35:r:z35; salmonella arizonae 35:z52:1, 5, 7; salmonella arizonae 58:rz53:z57 of three serologic groups. the attention was focused on more than 20 (new to this country) salmonellae among whic ... | 1977 | 595376 |
| [microheterogeneity of r plasmid coded beta-lactamases in analytical isoelectric focusing (author's transl)]. | analytical isoelectric focusing of plasmid-coded beta-lactamases in polyacrylamide gels gives rise to several satellite bands in addition to one major active band (microheterogeneity). when the r plasmids are transferred by conjugation into 4 different bacterial species (escherichia coli, klebsiella pneumoniae, salmonella typhi-murium, proteus mirabilis) the position of the main band remains constant, but the number and position of the satellite bands are changed. furthermore, the minimal inhibi ... | 1977 | 603191 |
| an outbreak of erysipelas in coturnix quails. | a severe outbreak of erysipelas causing high mortality was observed in coturnix breeder quails. possible source(s) of erysipelothrix infection in the flock and subsequent infections due to pasteurella multocida, salmonella typhimurium, and staphylococcus aureus are discussed. | 1977 | 606226 |
| mode of action of trichothecenes. | in the present discussion, the author summarized the toxicological and biological features of thirty kinds of trichothecene mycotoxins which are produced by a wide range of fusarium, myrothecium and others. the 12, 13-epoxytrichothecenes induce nausea, emesis, vomiting, skin inflamation, leukopenia, diarrhea, hemorrhage in lung and brain, and destruction of bone marrow. since these toxicological characteristics coincide with a major symptom of intoxicated humans and farm animals induced by consu ... | 1977 | 613939 |
| crankcase oils: are they a major mutagenic burden in the aquatic environment? | fractions from used crankcase oil enriched in polyaromatic hydrocarbons induced revertant colonies in salmonella typhimurium strain ta 98 when activated by rat or trout liver extracts. the mutagenic activity was not due to benzopyrene or benzanthracene. fractions from various crude and refined petroleums were nonmutagenic. among various petroleum hydrocarbons entering inland and coastal waters, used crankcase oils may represent a major mutagenic burden. | 1978 | 635591 |
| involvement of hepatic metallothioneins in hypozincemia associated with bacterial infection. | hypozincemia was induced in rats by salmonella typhimurium and live vaccine strain francisella tularensis (lvs) infections. hepatic synthesis of zinc-binding proteins (zbp) was studied in order to elucidate the mechanisms involved in the redistribution of zinc from plasma to liver occurring during infectious illness. zbp, labeled in vivo with 65zn, were isolated and identified as metallothioneins based, in part, on their heat stability, dimorphism, and amino acid composition. cysteine was the ma ... | 1978 | 645856 |
| intestinal bacterial flora of the household lizard, gecko gecko. | a total of 114 isolates was recovered from the intestines of 43 househould lizards, gecko gecko. among the important ones were staphylococcus aureus, salmonella typhimurium, pseudomonas aeruginosa, proteus mirabilis and edwardsiella tarda. | 1978 | 653125 |
| the critical role of iron in host-bacterial interactions. | the ability of potential pathogens to acquire iron in a host is an important determinant of both their virulence and the nature of the infection produced. virulent gram-negative bacteria are capable of acquiring sufficient iron from the host because their virulence (for chick embryos) is unaffected by exogenous iron. avirulent mutants which are apparently limited in their ability to acquire iron could be isolated from the virulent strains. the lethality of these mutants was significantly enhance ... | 1978 | 659605 |
| immunity to experimental salmonella infection: studies on the protective capacity and immunogenicity of lipopolysaccharide, acetone-killed cells, and ribosome-rich extracts of salmonella typhimurium in c3h/hej and cd-1 mice. | 1978 | 690428 | |
| salmonellosis associated with homemade ice cream. an outbreak report and summary of outbreaks in the united states in 1966 to 1976. | during the period 1966 to 1976, 22 outbreaks with 292 individual cases of salmonellosis associated with the consumption of homemade ice cream were reported to the center for disease control. salmonella typhimurium accounted for 45% of the outbreaks. the source of eggs used was known in 13 outbreaks, and all were ungraded farm- or home-produced eggs, a potential source of salmonellae. in 11 outbreaks, the method of preparation was known, and in all, the ice-cream custard had not been cooked befo ... | 1978 | 691200 |
| mutagenicity of dichlorvos and other structurally related pesticides in salmonella and streptomyces. | the following pesticides: azinphosmethyl, diallate, dichlorvos, eptc, fenchlorphos, mevinphos, monocrotophos, noruron, parathionmethyl, triallate, trichlorphon and vegadex were tested for the ability to induce his+ revertants in four histidines requiring strains of salmonella typhimurium--tai 535(missense), tai 536, tai 537 and tai 538 (frame-shift)- and resistance to low levels of streptomycin in streptomyces coelicolor. dichlorvos, which is a phosphoric ester with a dichlorovinyl group as side ... | 1978 | 699179 |
| salmonella arteritis: a precursor of aortic rupture and pseudoaneurysm formation. | salmonella arteritis developed in three patients with subsequent arterial rupture and pseudoaneurysm formation. they had a one- to two-week history of chills and fever, and blood cultures were positive for salmonella. pulsatile, tender abdominal masses developed in two patients with aortic infection while they were hospitalized. the third patient's femoral artery infection presented as a painful swelling behind the knee. arteriography demonstrated large vessel rupture with pseudoaneurysm formati ... | 1978 | 708237 |
| humoral immune responses in foetal sheep. | a total of fifty-two foetal sheep between 49 and 126 days gestation were injected with polymeric and monomeric flagellin, dinitrophenylated monomeric flagellin, chicken red blood cells, ovalbumin, ferritin, chicken gamma-globulin and the somatic antigens of salmonella typhimurium in a variety of combinations. immune responses were followed in these animals by taking serial blood samples from them through indwelling vascular cannulae and measuring the circulating titres of antibody. of the antige ... | 1978 | 711249 |
| heterogeneity and distribution of lipopolysaccharide in the cell wall of a gram-negative marine bacterium. | lipopolysaccharide (lps) extracted from alteromonas haloplanktis 214, variants 1 and 3, separated into three fractions when subjected to sodium dodecyl sulfate-polyacrylamide gel electrophoresis. the fractions appeared in the gels as bands which stained for carbohydrate with the periodate-schiff reagent. variant 1, a smooth variant of the organism, and variant 3, a rough colonial variant, produced identical banding patterns. under similar conditions, lps from neisseria meningitidis sdic, escheri ... | 1978 | 711665 |
| thermosensitive antibiotic resistance plasmids in enterobacteria. | of 775 conjugative plasmids found in enterobacteria mediating antibiotic resistance, 24 (3.1%) were thermosensitive (ts); they were most common in klebsiella pneumoniae. ts plasmids were also found in all the samples of sewage and river water examined. over half of 73 ts plasmids from unrelated sources mediated resistance to chloramphenicol in addition to several other antibiotics. many of them mediated resistance to mercury (53.4%), arsenite (38.4%) and tellurite (79.5%) but not to copper, coba ... | 1978 | 731207 |
| antibiotic resistance among predominant salmonella serovars and phagovars in canada. | the antibiotic susceptibility of 2609 salmonella isolates, collected during the period 1975-1976, was tested and the relationships between antibiotic-resistance pattern, source of isolation, and serovar and phagovar were determined. of 95 serovars examined, 40 were sensitive to all of the antibiotics tested. salmonella typhimurium was the major contributor to multiple resistance from both human and non-human sources. multiply resistant strains were not found from animal feed sources and, in addi ... | 1978 | 743644 |
| indigenous microorganisms prevent reduction in cecal size induced by salmonella typhimurium in vaccinated gnotobiotic mice. | germfree cd-1 mice challenged by the oral route with salmonella typhimurium had ceca that were abnormal in appearance and reduced in size compared to those of germfree controls. similarly, germfree mice injected with heat-killed s. typhimurium or gnotobiotes associated with three indigenous microbes (lactobacillus, bacteroides, clostridium), and subsequently challenged with s. typhimurium also had small ceca. by contrast, gnotobiotic mice that had been both injected with the heat-killed s. typhi ... | 1976 | 765282 |
| [immunologic capacity of ribosomal fractions prepared from salmonella schottmuelleri and salmonella typhimurium]. | 1975 | 765560 | |
| [localization of salmonella typhimurium in the body in chronic bacterial carrier state]. | 1975 | 765691 | |
| pyrimidine nucleoside analogues as inducers of pyrimidine nucleoside catabolizing enzymes in salmonella typhimurium. | various structural analogues of cytosine and uracil nucleosides were tested as potential inducers of the nucleoside catabolizing (cyt) enzymes in salmonella typhimurium. some analogues, e.g. 5'-o-alkyl cytidines and uridines, resistant to catabolic enzymes, were as effective as the natural inducers cytidine and uridine; but etherification of one of the cis 2' or 3'hydroxyls fully abolished activity, pointing to a requirement of an intact ribose cis-glycol system for activity. a uridine analogue ... | 1975 | 765767 |
| spontaneous and induced mutability or frameshift strains of salmonella typhimurium carrying uvrb and pola mutations. | three strains of salmonella typhimurium carrying frameshift mutations affectin g the histidine genes (hisc3076, hisd3052 and hisc207) showed increased sensitivity to mutagenesis by icr-191 (as judged by measuring back mutation to prototrophy), if they were made deficient in excision repair by deleting the uvrb gene. one frameshift strain, hisc3076, also showed increased sensitivity to mutagenesis by icr-191 when it carried either of two different pola alleles, whereas the hisd3052 and hisc207 fr ... | 1976 | 765803 |
| mutagenicities of nitrofuran derivatives on a bacterial tester strain with an r factor plasmid. | many nitrofuran derivatives are known to be mutagenic on escherichia coli wp2 but not on salmonella typhimurium ta1535, ta1536, ta1537 or ta1538. ames and coworkers recently obtained a new tester strain of s. typhimurium, ta100, by putting an r factor plasmid, pkm101, into ta1535. we found that all mutagenic nitrofuran derivatives previously found to be mutagenic on e. coli wp2 were mutagenic on this new strain (ta100). | 1976 | 765814 |
| detection of mutagenic activity of metronidazole and niridazole in body fluids of humans and mice. | after humans were treated at therapeutic doses with the trichomonacide metronidazole (flagyl) and the antischistosomal agent niridazole mutagenic activity was demonstrable in their urines when tested with the histidine auxotroph of salmonella typhimurium. both compounds were active in the host-mediated assay in mice, and evidence of activity was found in the blood and urine of mice treated with niridazole but not with metronidazole. | 1975 | 766186 |
| mutagenicity of malonaldehyde, a decomposition product of peroxidized polyunsaturated fatty acids. | incubation of histidine requiring auxotrophs of the bacterium salmonella typhimurium with malonaldehyde, a three-carbon dialdehyde, produced an increased number of revertants in specific strains. mutagenesis was only observed in frameshift mutants with normal excision repair and did not occur in those base-pair substitution mutants tested. the results are consistent with the cross-linking of bacterial dna by malonaldehyde leading to mutagenesis expressed through the error-prone repair system. | 1976 | 766187 |
| [salmonella typhimurium masked as an enterobacter species (author's transl)]. | a bacterial strain at first sight appearing to be an enterobacter species causing enteritis could be identified as salmonella typhimurium showing only a low formation of h2s. this small degree of h2s formation could not be demonstrated on commercial media ready for use. the high antibiotics resistance of the strain in question points to the possibility of its having undergone several antibiotics passages without recognition. thus, serological verification is recommended in the case of so-called ... | 1975 | 766502 |