Publications

features of the in vitro established rat large granular lymphocyte leukaemia rnk-16.	a large granular lymphocyte (lgl) leukaemia cell line from the fisher/f344 rat strain called rnk-16 has been established in vitro, maintaining the same surface markers as tumour cell growing in vivo. the tumour has also maintained its specificity pattern and cytotoxic reactivity and serves as a suitable source of natural killer (nk)-like effector cells in vitro. the cells show no evidence of dependency on, or production of, interleukin 2 or interferons, nor is the cytotoxic capacity influenced b ...	1988	3353687
early aneurysm surgery: a 7 year clinical practice report.	one hundred and fifty patients with intracranial aneurysms, operated on consecutively in the early stage in our department, were re-evaluated retrospectively. seven surgeons operated on 159 aneurysms in 150 patients. seventy-nine percent of the patients were in grades i-iii (scale of hunt and hess), 21% in grades iv-v. seventy-one percent had a severe haemorrhage (classification of fisher et al.), 21% had an intracerebral haematoma. intraoperative csf drainage was an almost indispensable tool wh ...	1988	3354369
comparative toxicity of halothane, isoflurane, hypoxia, and phenobarbital induction in monolayer cultures of rat hepatocytes.	hypoxia, phenobarbital induction, and halothane anesthesia have been implicated in the pathogenesis of hepatotoxicity in the rat model. however, a controversy exists over the role of halothane in liver injury; does it act by reducing hepatic blood flow, thereby inducing hypoxia, or do its metabolites initiate the injury? these variables are difficult to separate during in vivo halothane exposure. in the present experiments, effects of halothane on hepatic perfusion were eliminated by exposing co ...	1988	3354886
melted delivery hose--a complication of a heated humidifier.	the polyvinylchloride delivery hose of a fisher & paykel dual servo heated anaesthetic humidifier was melted by the intraluminal hose heater, causing a major leakage of anaesthetic gases during a surgical procedure. under experimental conditions, melting could be reproduced using polyvinylchloride but not polyester elastomer tubings. only tubings made of materials with high melting point should be used as delivery hose in heated humidifiers with hose heaters.	1988	3356055
blood-brain barrier transport of choline is reduced in the aged rat.	an age-related impairment in choline transport across the blood-brain barrier (bbb) may contribute to the cholinergic mechanisms of geriatric memory dysfunction. to test this hypothesis, the brain choline uptake in male fisher 344 rats at 2, 18 and 24 months of age was studied using the oldendorf technique. the vmax of choline transport in the 24-month-old rats (0.05 +/- 0.04 nmol/min/g) was significantly lower than that in the 2-month-old rat (2.5 +/- 1.0 nmol/min/g) (p less than 0.05). the km ...	1988	3359216
fexpac: a program for linear discriminant classification.	a new program for feature extraction and two-class classification utilizing the fisher linear discriminant function model has been developed. it is intended as a tool in multivariate data analysis, and is especially suited for the design and storage of linear classifiers from training data sets.	2000	3359769
clinical prediction of airways hyperresponsiveness.	we tested the ability of chest physicians to detect increased airways responsiveness (iar) in patients presenting with symptoms suggestive of asthma. physicians ordering bronchial provocation tests for diagnostic purposes were asked to predict the clinical probability (based on the patient's history, examination, and spirometry) of iar (defined by a pc20 for fev1 less than or equal to 8 mg/ml of histamine). presenting symptoms in the 38 subjects aged 16 to 78 years included cough, wheeze, dyspne ...	1988	3359851
directional selection and the evolution of breeding date in birds.	in many bird species, those pairs that breed earlier in the season have higher reproductive success than those that breed later. since breeding date is known to be heritable, it is unclear why it does not evolve to an earlier time. under assumptions outlined by fisher, a model is developed that shows how breeding date may have considerable additive genetic variance, appear to be under directional selection, and yet not evolve. these results provide a general explanation for a persistent correlat ...	1988	3363360
molecular cloning of cdna corresponding to mrna species whose steady state levels in the thyroid are enhanced by thyrotropin. homology of one of these sequences with ferritin h.	a lambda gt11 cdna library was constructed using poly(a)+ mrna from thyrotropin (tsh)-stimulated fisher rat thyroid (frtl5) cells. the library was screened for nonthyroglobulin cdna sequences by differential plaque filter hybridization using single-stranded cdna probes synthesized from mrna prepared from quiescent and tsh-stimulated frtl5 cells. thyroglobulin cdna-containing recombinants in the library were avoided by prehybridizing the tsh probe to excess thyroglobulin cdna. of 48,000 clones sc ...	1988	3366767
photoperiodic sensitivity of prepubertal female fisher 344 rats.	the laboratory rat is thought to be a poor model for study of the photoperiodic control of reproduction; however, this has only been investigated in a few rat strains. the purpose of the present investigation was to determine if the neuroendocrine-reproductive system of the fisher 344 (f344) rat, an inbred strain, is sensitive to light deprivation. all treatments were performed on 28-day-old female f344 rats and the animals maintained for 8 weeks in a 14:10 light:dark cycle. blinding resulted in ...	1988	3367261
sequential hormone therapy for advanced breast cancer.	sequential hormone therapy for advanced breast cancer can offer significant and prolonged disease control with minimal morbidity. predictors of response to sequential hormone therapy have not previously been identified. sixty postmenopausal women with advanced or recurrent breast cancer treated with sequential megestrol acetate and tamoxifen were evaluated to identify factors which predict response to sequential therapy. the response rate to first-line therapy was 28% (17/60). forty-seven percen ...	1988	3368799
effects of nicotine on the fertility, cytology and life span of male rats.	contrary to an earlier opinion that nicotine has no effect on the fertility of male animals or humans, the present experimental study using male inbred fisher rats demonstrates that the reproductive capacity of the animals is greatly reduced when injected with nicotine, and that the effect is much greater in male than in female fisher rats similarly injected with nicotine. this is in accord with some earlier histological and morphological studies which have shown that female rodents have a great ...	1988	3369287
[changes in capillary permeability in experimental brain tumor].	it is still controversial whether edema fluid around a malignant brain tumor is derived from capillaries inside the tumor itself or not only from tumor vessels but also from peritumoral tissue. the purpose of this study is to clarify the region where the capillary permeability is increased using double autoradiographic method. a suspension of 1 x 10(4) rat glioma cells (rg-12) was stereotactically implanted into the right basal ganglia of c-d fisher rats. in this model, all animals are dead 20 + ...	1988	3370167
multivariate spectral methods for the analysis of event-related brain potentials.	the purpose of this article is to present some useful mathematical models for the analysis of multiple electrode event-related brain potential (erp) experiments. we describe a multivariate spectral method for eye-movement removal and we also describe a multivariate spectral method for the analysis of multiple lead repeated measures data. the complex t2 and the complex behrens-fisher problem are also discussed. all of the above methods are applied to experimental erp data for four electrodes, two ...	1988	3370952
ventricular fibrillation during right coronary arteriography with ioxaglate, iohexol and iopamidol in dogs.	radiograph contrast media (cm) are known to produce myocardial disturbances during cardiac angiography. the most severe electrical disturbance is ventricular fibrillation (vf). previous studies using prolonged right coronary exposures have demonstrated a higher incidence of vf with dilute low sodium cm than with dilute cm containing more physiologic levels of sodium. in this study the incidence of vf was examined for more conventional concentrations of iopamidol, iohexol and ioxaglate and for so ...	1988	3372179
production and characterization of monoclonal antibodies to the protective antigen component of bacillus anthracis toxin.	thirty-six monoclonal antibodies to the protective antigen protein of bacillus anthracis exotoxin have been characterized for affinity, antibody subtype, competitive binding to antigenic regions, and ability to neutralize lethal and edema toxin activities. at least 23 antigenic regions were detected on protective antigen by a blocking, enzyme-linked immunosorbent assay. two clones, 3b6 and 14b7, competed for a single antigenic region and neutralized the activity of both the lethal toxin in vivo ...	1988	3384478
generation of anti-ssdna antibodies by persistent immunization of mice with sheep erythrocytes.	immunization of (dba/2) mice with sheep erythrocytes (1 x 10(8) red cells, once weekly for 2 months) elicited anti-sheep erythrocyte antibodies, a part of which combined with ssdna. by contrast, immunization with rat (fisher) erythrocytes (1 x 10(8) red cells, once weekly for 2 weeks) did not elicit antibodies cross-reactive with ssdna. the antibody response (igm and igg) to sheep erythrocytes rose sharply and subsequently tapered off (usually within the first 2 weeks). the level of igg antibodi ...	1988	3391634
focal brain ischemia in the rat: methods for reproducible neocortical infarction using tandem occlusion of the distal middle cerebral and ipsilateral common carotid arteries.	this article describes a 3-year experience with focal neocortical ischemia in three rat strains. multiple groups of adult wistar (n = 50), fisher 344 (n = 31), and spontaneously hypertensive (n = 72) rats were subjected to permanent occlusion of the distal middle cerebral (mca) and ipsilateral common carotid arteries (cca). twenty-four hours later the animals were killed, and frozen brain sections were stained with hematoxylin and eosin to demarcate infarcted tissue. the infarct volume for each ...	1988	3392112
growth of dunning transplantable prostate adenocarcinomas in rats fed diets with various fat contents.	the effects of dietary fat concentration (5 vs. 20% corn oil, 0.5 vs. 20% corn oil and fat-free vs. 20% corn oil) on the growth of the dunning r3327-h (hormone-sensitive, well-differentiated, slow-growing) and r3327-150 (hormone-insensitive, anaplastic, rapidly growing) transplantable prostate tumor sublines were studied in copenhagen x fisher f1 male rats. rats fed 5 vs. 20% corn oil or 0.5 vs. 20% corn oil showed no differences in either r3327-h or r3327-150 tumor growth. fat-free diets had no ...	1988	3392600
visualization and quantification of transplanted dunning prostate tumors in rats using magnetic resonance imaging.	quantitative magnetic resonance imaging (mri) has been used for the in vivo size determination of subcutaneously implanted dunning r3327-h tumors in male copenhagen-fisher rats (n = 18). images have been recorded using a multislice spin-echo sequence se(1000/36) with a resolution of 0.2 x 0.2 mm2 in the imaging plane and a slice thickness of 2 mm. the reliability in the mri size determination was of the order of 10%. the mri results were compared with caliper measurements. five months after tumo ...	1988	3393495
[hydrocephalus and vasospasm after subarachnoid hemorrhage from ruptured intracranial aneurysms].	the relationship of the amount of subarachnoid blood to the incidence of acute hydrocephalus, delayed vasospasm, and chronic hydrocephalus was investigated in 47 patients with subarachnoid hemorrhage from ruptured intracranial aneurysms. acute hydrocephalus, delayed vasospasm, and chronic hydrocephalus occurred in 29%, 7%, and 14% of fisher group 1 & 2 patients respectively, in contrast, 70%, 64%, and 58% of fisher group 3 patients (p less than 0.01). thirty six percents of all patients had both ...	1988	3399001
[ophthalmoplegia, ataxia and areflexia: the miller fisher syndrome].		1988	3420583
[neurophysiological studies in a case of miller fisher syndrome].		1987	3423387
metabolism of pyrilamine maleate in fischer 344 rats, part i: activity excretion profiles.	male and female fisher 344 rats (12 per group) were dosed by gavage with either 2 or 10 mg (based on the free amine) pyrilamine maleate containing about 12 and 6 muci 14c-pyrilamine maleate, respectively, to determine excretion of the activity as a function of dose and sex with time. urine and feces were collected at timed intervals through 144 h. most of the dose (about 70%) was eliminated within 48 h through the urine and feces, but only about 80% of the total dose was recovered during the exp ...	1987	3431093
enhanced expression of harvey-ras oncogene in fanft-induced transitional cell carcinoma.	the level of mrna expression and dna structure of c-h-ras were examined in a transitional cell carcinoma (tcc) induced in c3h/he mice and fisher rats by n-(4,5-nitro-2-furylthiazolyl)formamide (fanft) and carried as serially transplanted tumors. neither amplification nor gross rearrangements were detected by southern analysis in the fanft tumor. increased expression of c-h-ras was detected by northern and in situ hybridization in both the fanft-induced mouse and rat tcc, as compared to normal ur ...	1987	3433577
molecular cloning and sequence analysis of the cdna for small proteoglycan ii of bovine bone.	the cdna for the full-length core protein of the small chondroitin sulphate proteoglycan ii of bovine bone was cloned and sequenced. a 1.3 kb clone (lambda pg28) was identified by plaque hybridization with a previously isolated 1.0 kb proteoglycan cdna clone (lambda pg20), positively identified previously by polyclonal and monoclonal antibody reactivity and by hybrid-selected translation in vitro [day, ramis, fisher, gehron robey, termine & young (1986) nucleic acids res. 14, 9861-9876]. the cdn ...	1987	3435485
a case of recurrent miller-fisher syndrome.		1987	3435804
effect of lithium on circadian activity of ache (ec 3.1.1.7) in the reticular formation of mouse brain stem under ld 12:12.	the investigation was carried out on male mice 6-8 weeks old. control animals were fed standard chow without lithium, while the experimental ones received on additional 10 mmol licl/kg of chow. after 30 days feeding, 7 mice at a time were killed every 4h. the activity of free ache was assessed in the brain stem reticular formation according to the method of ellman. the results were statistically analyzed using student's t-test and fisher test. parameters of periodic function were then applied to ...	1987	3446450
comparative ototoxicity of gentamicin in the guinea pig and two strains of rats.	gentamicin ototoxicity and nephrotoxicity were compared in two strains of rats, sprague-dawley and fisher-344, and in the hartley albino guinea pig. treatment groups consisting of 8 male rats of each strain and four male guinea pigs were dosed subcutaneously for 14 days with either 80 or 100 mg/kg of gentamicin sulfate in saline. brainstem auditory evoked response (baer) thresholds were recorded from each animal in each group on day 11 post-administration. blood urea-nitrogen and serum creatinin ...	1987	3446672
changes in the hepatic perfusion index during the growth and development of experimental hepatic micrometastases.	micrometastases were induced in fisher rats using an intraportal inoculation of 0.2 ml of 8 x 10(7) walker carcinosarcoma cells. a control group received normal saline. the hepatic perfusion index (hpi) was measured during the growth and development of micrometastases. the hpi at 4 days (0.51 +/- 0.008) and at 6 days (0.65 +/- 0.16) was significantly raised when compared to controls (0.31 +/- 0.07) and at 2 days after inoculation (0.31 +/- 0.06). hepatic artery flow did not change throughout the ...	1987	3449796
[neurobiology in panic states].	research in panic disorder (pd) has highlighted a low biological threshold (lactate infusion). also, several studies have shown neurophysiological changes with pd patients: increased brain perfusion (stewart), parahypocampal hyper-perfusion (reiman) and we reported an increased incidence of epileptiform abnormalities. in order to assess neuroanatomical changes we carried out a study with magnetic resonance imaging (mri) of p.d. as compared to controls. a prospective study with mri was done with ...	2006	3451675
effect of retinoids on the growth of squamous cell carcinoma of the palate in rats.	the in vivo effects of retinoids on head and neck tumors were studied using fisher 344 rats with squamous cell carcinoma implanted in the palate. retinoids were given orally to rats, starting 2 weeks after tumor implantation. the animals were killed at 4 weeks, and the tumor volumes and body weights were measured. the animals had a greater response to all-trans-retinoic acid (58 per cent) and 13-cis-retinoic acid (60 per cent) than to all-trans-retinol (20 per cent) and 13-cis-retinal (30 per ce ...	1986	3456728
radiofrequency hyperthermia with successive monitoring of its effects on tumors using nmr spectroscopy.	radiofrequency (rf) hyperthermia was generated on rat glioma inoculated s.c. in cd fisher rats by applying the rf pulse using the surface coil in the nmr spectrometer, and the effect was monitored successively in the same spectrometer by measuring 31p nmr spectra and 1h nmr images. in the 31p nmr spectrum at the preirradiation stage, nucleoside triphosphate peaks and a phosphomonoester peak were high and a pi peak was low. after a rf pulse at a power of 5 w was applied continuously for 60 min, t ...	1986	3464955
stimulatory effect of interleukin-1 upon hepatic metabolism.	the liver plays an important role in the acute-phase response to sepsis and injury, and host survival often depends upon an adequate hepatic response. many of the metabolic sequelae to sepsis and injury are mediated by interleukin-1. this study was undertaken to investigate the impact of interleukin-1 upon hepatic metabolism and whether this mediator acted directly upon the liver. interleukin-1 (5 rabbit pyrogen dose units) was administered to male fisher f344 rats (175 to 200 g), and hepatocyte ...	1986	3486338
acetylation phenotype and hepatotoxicity in the treatment of tuberculosis in children.	we studied the relationship between acetylation phenotype and the appearance of biochemical and clinical signs of liver damage in 73 tuberculous children treated with isoniazid and rifampin. no significant differences were found with respect to the distribution of acetylation phenotype between tuberculous patients and a control group consisting of 256 children. hepatotoxicity manifested in 27 cases (37%), of which only five (7%) had clinical signs. application of the fisher exact probability tes ...	1986	3487069
mechanism of inhibition of rtem-2 beta-lactamase by cephamycins: relative importance of the 7 alpha-methoxy group and the 3' leaving group.	cefoxitin is a poor substrate of many beta-lactamases, including the rtem-2 enzyme. fisher and co-workers [fisher, j., belasco, j. g., khosla, s., & knowles, j. r. (1980) biochemistry 19, 2895-2901] showed that the reaction between cefoxitin and rtem-2 beta-lactamase yielded a moderately stable acyl-enzyme whose hydrolysis was rate-determining to turnover at saturation. the present work shows first that the covalently bound substrate in this acyl-enzyme has a 5-exo-methylene-1,3-thiazine structu ...	1986	3487346
outbreak of candida parapsilosis endophthalmitis after cataract extraction and intraocular lens implantation.	between november 1983 and january 1984, 13 cases of candida parapsilosis endophthalmitis occurred in florida, georgia, and tennessee in patients who had had an intraocular lens implantation (ioli) or cataract extraction with an ioli. this outbreak followed the introduction in july 1983 of a new brand of balanced salt solution (bss) used as an intraoperative ophthalmic irrigation solution. this product was subsequently recalled because of intrinsic fungal contamination. a retrospective cohort stu ...	1986	3490490
development of an experimental animal model for reactive arthritis induced by yersinia enterocolitica infection.	we attempted to induce experimental arthritis in rats by systematically testing the effect of yersinia infections in five strains of rats, using the intragastric, intraperitoneal, and intravenous routes of inoculation. we observed that lewis rats which were given 10(4) to 10(5) yersinia enterocolitica wa organisms via the intravenous route consistently developed arthritis. the arthritis was most severe at 3 weeks and subsided at 6 weeks. no arthritis was observed when this bacterial strain was a ...	1987	3493220
co-purification of transforming growth factor beta-like activity with pth-like and bone-resorbing activities from a tumor associated with humoral hypercalcemia of malignancy.	humoral hypercalcemia of malignancy (hhm) is caused by a circulating bone-resorbing factor or factors. suggestions as to the nature of this factor include pth-like proteins, transforming growth factors, and bone-resorbing factors distinct from either of the first two classes of polypeptides. we investigated the occurrence of these three activities in a highly purified extract of the h-500 leydig cell tumor which causes hhm when implanted into fisher rats. pth-like adenylate cyclase-stimulating a ...	1987	3494596
direct stimulation of the adrenal cortex by interleukin-1.	the impact of human recombinant beta-interleukin-1 (il-1) on adrenocortical stimulation was investigated. this study asked three questions: does il-1 increase the corticosterone levels of rat serum? is there a direct effect on the adrenal cortex? what is the mechanism of this effect? the intraperitoneal injection of il-1 (70 micrograms) in anesthetized male fisher rats resulted in elevated corticosterone levels at 30 minutes and reached a maximum at 180 minutes (94 +/- 12 versus 34 +/- 4 microgr ...	1987	3497458
survival of sylvatic trichinella spiralis isolates in frozen tissue and processed meat products.	the ability of trichinella spiralis larvae to survive at subfreezing temperatures encysted in the musculature of wild carnivorous mammals was assessed by evaluating motility and infectivity (to rodents) of trichinae at various intervals after storage in frozen skeletal muscle. fifty to 60% of the larvae in grizzly bear meat were alive after storage for 27 months at -6.5 to -20 c, and 30% to 50% were still alive at 34 months. however, none survived for 38 months, on the basis of infectivity in mi ...	1986	3505925
token swap test of significance for serial medical data bases.	established tests of statistical significance are based upon the concept that observed data are drawn randomly from a larger, perhaps infinite source population. the significance value, p, is the probability that the observations are drawn from a source population satisfying the null hypothesis; if p is small enough (less than 5 percent, 1 percent, etc.), then the null hypothesis is rejected. serial medical data bases, such as a hospital clinic intake or autopsy case accessions, often do not hav ...	1986	3511687
in vitro estimation of acoustic parameters of the liver and correlations with histology.	freshly excised human liver specimens (77) were investigated echographically and histologically. the echography was concerned with the acoustic parameters: speed of sound, impedance, several attenuation parameters, and the texture parameters: reflectivity and the signal to noise ratio. it was found that the speed and impedance, the attenuation parameters, and the texture parameters did not correlate with each other. the major correlation between histologic parameters was found for the focal coll ...	1986	3515717
some parameters of conditioned immunosuppression: species difference and cs-us delay.	three experiments were conducted in which an illness-inducing immunosuppressant, cyclophosphamide (an unconditioned stimulus, us) was associated with a previously presented saccharin solution conditioned stimulus (cs). in each experiment, reexposure to the cs produced a conditioned suppression of the plaque-forming-cell response in the experimental groups. experiment i demonstrated this result with fisher 344 rats. experiment ii replicated the effect with balb/c mice. in experiment iii condition ...	1986	3520612
different interactions used by cro repressor in specific and nonspecific dna binding.	the mode of interaction of cro repressor with specific and nonspecific sites on dna was explored by chemical modification and protection of lysine and tyrosine residues. cro has 8 lysines. in the presence of dna, lysines 32 and 56 are fully protected and lysines 21, 62, and 63 are partially protected from alkylation. however, the terminal amino group and lysines 8, 18, and 39 are not protected. location of the protected and unprotected lysines on the three-dimensional cro structure defines a dna ...	1986	3522575
the effectiveness of citric acid as an adjunct to surgical re-attachment procedures in humans.	the purpose of this study was to clinically evaluate the effect of citric acid on re-attachment and re-adaptation in conjunction with periodontal surgery. a split-mouth design was used in 10 patients involving 30 quadrants of surgery. a total of 120 teeth were treated. each quadrant consisted of at least 2 teeth from cuspid to second molar. one quadrant was treated with a modified widman flap alone while the root surfaces of the contralateral side were also treated with a 3 min application of ci ...	1986	3531246
what about r.a. fisher's statement of the "too good" data of j.g. mendel's pisum paper?	mendel was accused by fisher that his observed data, which corresponded to expectations, were too good to be true, and, further, that mendel, growing only 10 plants per offspring, disregarded in his genotypical analysis the loss of recessives by assuming a ratio of 1:2 instead of 1.1126:1.8874. in contrast, it is proposed here that all chi-square statistics of genetic segregations fall short because the variance of genetic segregations is smaller and not of a binomial type as assumed. furthermor ...	2008	3531317
genitalia in children's drawings: an association with sexual abuse.	many sexual abuse victims have been observed to draw genitalia on human figures. to test the hypothesis that sexually abused children draw genitalia on human figures more often than do nonabused children, drawings from 57 children, 3 through 7 years of age, who were referred to child protective services as alleged sexual abuse victims, were compared with drawings from an age-, sex-, race-, and socioeconomically matched group of 55 nonabused children receiving well-child care in medical settings. ...	1987	3540833
1986 elda e. anderson award presented to darrell reed fisher.		1987	3546201
skin graft and kidney transplantation in rats. relation between circulatory condition of the transplanted organ and histocompatibility.	to determine the relationship between histocompatibility and circulation in the transplanted graft, which are the major factors influencing graft survival, the survival of the skin grafts and kidney transplants were compared between strong (aci to lewis) and weak (fisher to lewis) histocompatible strains, because rats given skin graft receive poor blood supply from a recipient, and the rats given kidney transplants receive immediate blood supply after transplant. in the group with a weak histoco ...	1986	3547526
the effect of nicotine and alcohol on the fertility and life span of rats. a cytological analysis.	inbred fisher and buffalo rats were exposed to nicotine and alcohol. fertility was greatly reduced in both strains with nicotine treatments being much more deleterious than alcohol use. fisher rats tolerated both toxins better than buffalo rats. both strains became 'extinct' after one generation of fetal and postnatal exposure to nicotine, but alcohol-ingesting fisher rats had 3 or more generations of offspring. the total reproductive period was significantly shortened in both strains under the ...	1987	3548201
capillary tortuosity and degree of contraction or extension of skeletal muscles.	the effect of muscle contraction, and extension, on capillary anisotropy was investigated in rat m. soleus fixed by vascular perfusion at sarcomere lengths ranging from 1.62 micron (tetanizing stimulation of sciatic nerve) to 2.85 micron (ankle joint maximally flexed. capillary length density and tortuosity were estimated by morphometry using two sets of sections (0 and 90 degrees to the fiber axis). capillary orientation distribution was evaluated from a series of sections taken at 0 to 90 degr ...	1987	3550394
theoretical analysis of single-round transcription experiments on trp leader region.	a kinetic model is proposed to reproduce the time courses of the concentration change in paused leader rna, terminated leader rna, and readthrough rna in the single-round transcription experiments on trp leader region of escherichia coli and its mutants, l132, l75, and l75l135 (winkler, m. e., and c. yanofsky, 1981, biochemistry, 20:3738-3744; fisher, r., and c. yanofsky, 1983, j. biol. chem., 258:9208-9212). this model fits the experimental results well and also captures the essential aspects o ...	1987	3552070
evaluation of contextual analysis for computer classification of cervical smears.	a procedure for automated analysis of cervical smears has been implemented in an image cytometry system. smears are described exclusively in terms of global and contextual information extracted by pattern-recognition algorithms and represented by a vector of proportions of cellular object types. linear discriminant functions, based on a fisher criterion, are derived to classify smears with a cross-section of diagnoses into two broad categories, normal and abnormal. results obtained from 83 smear ...	1987	3556101
effects of carotid compression, as assessed by near infrared spectroscopy, upon cerebral blood volume and hemoglobin oxygen saturation.	near infrared spectroscopy, a recently developed optoelectronic technique, has been studied as a possible method of monitoring the adequacy of cerebral perfusion in 22 patients who were candidates for carotid endarterectomy. using this technique, changes in haemoglobin volume, haemoglobin oxygen saturation and redox level of cytochrome-c-oxidase were recorded from the frontoparietal region during routine carotid compression tests performed under continuous electroencephalographic (eeg) monitorin ...	1987	3560151
degeneration of hippocampal fibers and spatial memory deficit in the aged rat.	old and young fisher 344 rats were compared for their ability to learn a delayed alternation task. the old animals displayed significant impairment of alternation learning, and were slower than the young animals. the brains of these animals were examined using a silver degeneration stain, and among old rats there was conspicuous degeneration. the greatest density of degenerating fibers was seen in the hippocampus and in anatomically related tracts, but there was substantial fiber staining in the ...	1987	3561664
effect of aging on pancreatic lipolytic enzymes.	pancreatic lipolytic enzyme activities and plasma lipids were measured in three age groups of female fisher 344 rats (3 months [young], 12 months [adult], and 27 months [old]) in order to evaluate age-related changes and a possible correlation of these parameters. cholesterol esterase activity was measured in pancreas homogenate, while the lipase activity was further fractionated into heparin-sepharose unretained (lipase i) and retained (lipase ii) fractions. in analogy to the lipolytic enzymes ...	1986	3562438
heat-stress proteins of rat lung endothelial and mammary adenocarcinoma cells.	a rat mammary adenocarcinoma cell clone, mtc, and a rat lung endothelial cell clone, rle cl.4, both syngeneic to the fisher 344 rat, were compared for proteins synthesized at 37 degrees c and after a 1-h, 42 degrees c heat dose. the heat stress-induced or -enhanced synthesis of a series of molecular mass groups and isoelectric point species (isomers) was observed in both equilibrium and nonequilibrium two-dimensional gel electrophoresis. tumor and endothelial cell heat-stress proteins (hsp) were ...	1987	3562792
the bingo model of survivorship. iii. genetic principles.	the broad relationships are explored between the genetic and the phenotypic structures of the bingo-gamma model (ie, the shortest waiting time among competing, independent, multiple-hit systems). finite algorithms are derived to compute in closed form the joint and marginal distributions; the distribution, density, and hazard functions of time to failure; the respective total probabilities of dying from failure of each competing system; and the raw and central moments. the algorithm is the compu ...	1987	3565481
ligand blotting with 125i-fluoresceinamine-heparin.	a highly sensitive method for ligand blotting with heparin has been developed. this ligand-blotting method is successful largely due to the ability to prepare heparin derivatives of high radiospecific activity. heparin was modified with fluoresceinamine according to the method of c.g. glabe, p.k. harty, and s.d. rosen [1983) anal. biochem. 130, 287-294), and this fluoresceinamine-derivatized heparin can be radioiodinated to a specific activity of 100,000 cmp/ng of uronic acid. this is a 500-fold ...	1987	3565746
laboratory proficiency test results on use of selective media for isolating pseudomonas cepacia from simulated sputum specimens of patients with cystic fibrosis.	pseudomonas cepacia colonization of or infection in patients with cystic fibrosis (cf) has been associated with increased morbidity and premature death. however, current data on national incidence may be biased because of interlaboratory differences in the methods of culturing sputa of patients with cf. we conducted three tests to evaluate the proficiency of microbiology laboratories at cf centers in identifying and isolating p. cepacia and to assess the value of using selective media for p. cep ...	1987	3571451
increased incidence of abnormal foetuses in the offspring of cyclophosphamide-treated male mice.	the incidence of morphologically abnormal foetuses in the litters of cyclophosphamide (cp)-treated male mice was investigated and compared with control values. in two experiments (100 mg/kg) cp was shown to increase the incidence of grossly abnormal foetuses over that seen in the controls, although neither was statistically significant in isolation. when the probabilities from the two tests of significance were combined using the method of fisher the result was significant (p = 0.02). these resu ...	1987	3574337
[clinical considerations and eeg-ct correlations in lacunar infarcts].	56 cases of lacunar stroke were reviewed retrospectively. the patients showed a clinic picture which could be classified within nine of the lacunar syndromes recognized by fisher. the localization of the lacunes was considered with respect to the clinical symptoms and the characteristics of the eeg and the tc and their different correlations were examined. the eegrafic patterns of the lacunar strokes with normal tc were compared with those showing an altered one. our study suggests that the abse ...	2013	3589409
[the double pontine lesion of fisher].	c. miller fisher described separately two pontine syndromes, that he called "the one-and-a-half syndrome" and "ataxic hemiparesis". the authors report the case of a woman who developed simultaneously the two syndromes, caused by a stroke of pontine localization, and comment about the structures involved by the lesion.	1986	3593035
growth of 9-l and rt-9 gliosarcoma in female rats.	published studies of 9-l and rt-9 gliosarcoma have been done only in male rats and it is widely assumed that these tumors do not grow in female rats. in this study 9-l and rt-9 gliosarcoma was inoculated into the brains of male and female fisher cd rats. the tumors grew with essentially the same incidence and survival time in both sexes, confirming that female rats can be used as well as male rats in experiments using rt-9 and 9-l gliosarcomas.	1987	3598624
demyelinating optic neuropathy with miller-fisher syndrome. the case for overlap syndromes with central and peripheral demyelination.	the syndrome of ataxia, areflexia and ophthalmoplegia, or miller-fisher syndrome, has been considered to be a variant of guillain-barré syndrome with pathology restricted to the peripheral nervous system. a patient with miller-fisher syndrome and bilateral demyelinating optic neuropathy suggesting associated central nervous system pathology is presented. clinical and experimental evidence regarding the association of central and peripheral nervous system demyelination is reviewed.	2012	3612209
effects of dichloroacetate in spinal stroke in the rabbit.	high levels of brain lactate may contribute to cellular death and dysfunction in acute cerebral ischemia. although sodium dichloroacetate (dca) has been shown to lower brain lactate in incomplete cerebral ischemia, functional outcome has not been assessed with dca. we examined the effects of dca treatment on functional neurologic outcome using a previously developed model for "spinal stroke" in the rabbit. thirty male new zealand white rabbits weighing 1.3-2.8 kg were studied. after anesthesia w ...	1987	3613862
mri in miller fisher variant of guillain-barré syndrome.		1987	3614677
initiating activity in a two-stage mouse skin model of nine mutagenic pyrolysates of amino acids, soybean globulin and proteinaceous food.	trp-p-1, trp-p-2, mea alpha c, a alpha c, glu-p-1, glu-p-2, lys-p-1, iq and phe-p-1 were tested for tumour initiating activity in a two-stage skin carcinogenesis model using 12-o-tetradecanoylphorbol-13-acetate (tpa) as the promoter. the total initiating doses were 20 mg for trp-p-1, trp-p-2, glu-p-1 and glu-p-2, 40 mg for mea alpha c and a alpha c, 5 mg for lys-p-1, 7.5 mg for iq and 100 mg for phe-p-1. 7,12-dimethylbenz[a]anthracene was used as a positive control compound at a total dose of 10 ...	1987	3621463
the effect of indomethacin on burn-induced immunosuppression.	recent interest in the role of prostaglandin inhibitors as immunomodulators following major injury prompted us to study the effect of indomethacin on burn-induced immunosuppression in rats as measured by the delayed-type hypersensitivity (dth) skin test response, ability to contain an intradermal bacterial challenge (10(8) staphylococcus aureus 502a injected intradermally), and overall survival from spontaneous burn wound sepsis. fifty male sprague-dawley rats sensitized to keyhole limpet hemocy ...	1987	3626543
strain differences in circadian drinking behaviors of ethanol and water in rats.	voluntary drinking responses to an alternating three-bottle, two-choice paradigm to tap water or to 5% ethanol were measured in adult male fisher (fshr; n = 14) and spontaneously hypertensive (sp; n = 16) rats for 6-9 days. all animals were singly caged and housed separately in isolation chambers. the animals received light from 0600 to 1800 (cst) daily (ld 12:12) or remained in constant darkness (dd) at room temperature (23 degrees c). food was freely available. water and ethanol bottles were c ...	1987	3628356
bha (2(3)-tert-butyl-4-hydroxyanisole)-mediated modulation of acetaminophen phase ii metabolism in vivo in fisher 344 rats.	adult male fisher 344 rats (190-220 g), were given an intravenous dose (10 mg/rat) of bha. pretreated and control rats received an intravenous dose of [g-3h] acetaminophen (25 mg/rat). bile was collected prior to dosing and for 5-6 hours after dosing at varying time intervals. separate aliquots of 0.2 ml were incubated with beta-glucuronidase and sulfatase, respectively. these incubation mixtures were then extracted and analyzed by reverse phase hplc. in all cases control animals showed a greate ...	1987	3628963
optimal experiment design for nonlinear models subject to large prior uncertainties.	classical experiment design generally yields an experiment that depends on the value of the parameters to be estimated, which are, of course, unknown. assuming that the model parameters belong to a population with known statistics, we propose to take the a priori parameter uncertainty into account by optimizing the mathematical expectation of a functional of the fisher information matrix. this optimization is performed with a stochastic approximation algorithm that makes robust experiment design ...	1987	3631311
[fisher harbor båtsfjord--have: modern health center--seek: nurses. interview by bjørn arild ostby].		1986	3641465
critical role of gonadal hormones on the genotoxic activity of the hepatocarcinogen dl-zami 1305.	the dna damaging capacity of the sex-dependent hepatocarcinogen beta-blocker dl-1-(2-nitro-3-methyl-phenoxy)-3-tert-butylamino-propan-2-ol (dl-zami 1305) was evaluated in different sex hormonal conditions. a single injection of dl-zami 1305 causes dna damage in the liver of the female but not the male wistar rat. when the hormonal environment of the female rat is converted to 'male type' by ovariectomy and 1 week of treatment with testosterone, dna damage by dl-zami 1305 is completely abolished. ...	1987	3652027
lens protein composition, glycation and high molecular weight aggregation in aging rats.	because of minimal or no turnover, lens proteins are subjected to substantial post-translational modifications which in turn disrupt lens architecture and change the optical properties leading to senile cataract formation. progressive glycation is believed to have the potential to initiate the changes that are conducive to lens opacification. fisher 344 rats were systematically followed from juvenile to older and aged phases of their life to study the relationship between lens glycation and high ...	1987	3654142
the comparative validities of six mmpi repression scales.	the validities of six mmpi repression scales were compared using each of the other five and an independent measure as criteria (n = 190). the data gave little support to the eichman, welsh, and haan repression scales as operational definitions of this construct. the results for the little-fisher denial, byrne et al. r-s, and haan denial scales showed more promise.	1987	3667939
gentamicin-induced loss of basolateral surface area of rat proximal convoluted tubules.	this study was performed to find the quantitative relationship between basolateral surface alterations of proximal convoluted tubules (pct) and renal failure in 26 fisher 344 rats receiving 20 mg/kg of gentamicin twice daily up to 28 days. they were sacrificed on day 14 (renal failure, 13 rats) and day 28 (recovering, 13 rats). control rats were used for morphologic studies (19) and serum creatinine studies (6 of 19). pcts (14th and 28th day) were graded as to severity with transmission electron ...	1987	3669615
genetic variability in response to dietary calcium.	supplemental dietary calcium has been shown to reduce blood pressure in spontaneously hypertensive rats while restricted calcium diets cause an elevation in blood pressure. this latter nutrient effect has been enhanced by modest sodium restriction and is associated with a reduction in serum ionized calcium concentration. to determine whether alterations of dietary calcium and sodium have a similar influence on blood pressure in genetically normotensive rats, fisher 344, wistar furth, and aci rat ...	1987	3669918
sodium citrate in paediatric outpatients.	to determine whether the gastric content ph of paediatric patients could be raised in an effort to decrease post-aspiration morbidity and mortality, the antacid sodium citrate (0.4 ml.kg-1) was given preoperatively to 25 patients aged 1 to 14 (6.0 +/- 3.5, mean +/- sd) years. their gastric content ph was measured following induction of anaesthesia. these values were compared to those obtained from a control group (n = 20) ranging in age from seven months to nine (3.3 +/- 2.7) years. a gastric co ...	1987	3677279
x-ray crystallographic studies of the alanine-specific racemase from bacillus stearothermophilus. overproduction, crystallization, and preliminary characterization.	to facilitate large-scale purification and crystallographic study, we have subcloned the gene for the alanine racemase of bacillus stearothermophilus from picr401 (inagaki, k., tanizawa, k., badet, b., walsh, c. t., tanaka, h., and soda, k. (1986) biochemistry 25, 3268-3274) and overproduced the enzyme in escherichia coli w3110 laciq using the tac promoter of pkk223-3. this system yields alanine racemase as 6% of the bacterial cytosolic protein. purification by a modification of the procedure of ...	1987	3680197
effect of an hypercholesterolemic diet on the level of several serum lipids and apolipoproteins in nine rat strains.	to detect the response of different strains of rats to an hypercholesterolemic diet, 9 different strains of male rats were fed successively a control diet (c) containing 20% casein for 4 weeks, then a high-protein, cholesterol-rich diet (hc) containing 50% casein and 1.2% cholesterol for 12 weeks. when the rats were fed the control diet, the highest cholesterolemia was found in the lou strain and the lowest in the wag and brown-norway (bn) strains. the latter strain had the highest free to ester ...	1987	3685615
variants of guillain-barré syndrome: miller fisher syndrome, facial diplegia and multiple cranial nerve palsies.	we report the experience at a large teaching hospital over a 10 year period with miller fisher syndrome, facial diplegia, and multiple cranial nerve palsies. in these patients, absence of drowsiness on examination, normal cranial ct scans, albumino-cytological dissociation on csf examination and slowing of nerve conduction, all suggest that a peripheral nerve dysfunction is the underlying mechanism. pertinent literature is reviewed, in an attempt to separate these probable variants of guillain-b ...	1987	3690433
ethyl acrylate distribution, macromolecular binding, excretion, and metabolism in male fisher 344 rats.	we have demonstrated previously that ethyl acrylate causes severe acute forestomach (nonglandular portion of the stomach) toxicity in rats. ethyl acrylate was also shown to cause forestomach tumors when administered to rats chronically by gavage. the current studies were designed to investigate ethyl acrylate distribution, excretion, and metabolism, as well as the macromolecular interactions of ethyl acrylate (etac) in the forestomach (target organ) and liver (nontarget organ). 2,3-[14c]ethyl ac ...	1987	3691998
nosocomial rotaviral diarrhea: pattern of spread on wards in a children's hospital.	nosocomial gastroenteritis in a 315-bed hospital for children was examined prospectively from january 11 through may 31, 1985. there were 85 cases of nosocomial diarrhea during the study period, and these were identified on each of the 13 hospital wards. rotavirus was identified in 40% of cases. incidence of nosocomial rotavirus was highest on wards where most children were less than 2 years of age, except for the infectious diseases (isolation) ward (0.24 versus 2.30 cases per 100 admissions, p ...	1987	3694179
quantitative investigation of the morphological plasticity of synaptic junctions in rat dentate gyrus during aging.	the morphological plasticity of synaptic junctions was investigated by means of quantitative stereology in the dentate gyrus supragranular layer of young (3 months), adult (12 months) and old (30 months) female fisher 344 rats. the numerical (nv) and surface (sv) density and the average surface area (s) of epta-stained synaptic junctions were calculated on 100 em pictures per age group. we found that nv significantly increased between the young and adult group and decreased in old animals when c ...	1986	3697677
a case of recurrent idiopathic ophthalmoplegic neuropathy (miller fisher syndrome)		1986	3701363
the genetics of quantifiable homeostasis: i. the general issues.	some fundamental issues in developing the quantitative genetics of heritable traits are addressed. such a trait must be capable of being represented as a quantity. choice of the metric can be satisfactorily made only in the light of some insight into the nature of the trait and what its revealing characteristics may be. this insight is likely to change as more is known about the process, so the form and detail of the analysis is not static but perhaps continually evolving. much has been made out ...	1986	3706403
a concentration of fucosylated glycoconjugates at the base of cone outer segments: quantitative electron microscope autoradiography.	rod photoreceptors show a discrete band of labeled molecules at the outer segment base shortly after the administration of radioactive protein precursors (young, 1967). the band signifies the insertion of radiolabeled protein, primarily opsin, into rod disc membrane (basinger, bok and hall, 1976). in contrast, the autoradiographic labeling pattern in cones is characteristically diffuse (young, 1971), although cones as well as rods are now thought to replace their disc membranes continually (ande ...	1986	3709697
correlation of 1a afferent conduction with the ataxia of fisher syndrome.	the pathophysiology of the ataxia in fisher syndrome (the syndrome of acute ophthalmoplegia, ataxia, and areflexia) has been attributed to both peripheral nervous system pathology and cerebellar system dysfunction. pathologic studies have demonstrated no consistent central nervous system abnormalities. we present a case in which abnormalities of 1a sensory conduction were found to correlate directly with the degree of ataxia, without impairment of motor or cutaneous sensory conduction. we propos ...	1986	3713737
renal and hepatic interactions between 2-hexanone and carbon tetrachloride in f-344 rats.	fisher-344 rats were pretreated with 2-hexanone (hx) and challenged with carbon tetrachloride (ccl4) in a replicated 3 x 4 factorial experiment to determine if hx potentiated ccl4-induced renal and hepatic damage. rats given both hx and ccl4 demonstrated more severe hepatic injury at 24 and 48 h than did controls. however, in contrast to our experience with chloroform (chcl3), ccl4-induced renal injury in hx-pretreated rats was only slightly greater than in vehicle-pretreated controls.	1986	3715912
[electron microscopic microanalysis of prickle cell carcinoma, basaloma, malignant melanoma and normal skin].	emma has been used in dermatology since 10 years. in 1981, fisher established the cu/zn index as a parameter for the prognosis of malignant melanoma. we tested the emma technique as a means to determine the cu/zn index in basal cell carcinoma, squamous cell carcinoma, malignant melanoma, and normal skin. our preliminary conclusions are: emma may be useful to determine the cu/zn index in skin tumors; it is possible to obtain useful data from tumors already fixed in paraffin; (c) the highest cu/zn ...	1986	3716530
divergence paralysis as the initial sign in the miller fisher syndrome.		1986	3717265
nadph binding induced proton ionization as a cause of nonlinear heat capacity changes in glutamate dehydrogenase.	functional group interactions involved in the formation of the glutamate dehydrogenase-nadph binary complex have been studied by three independent but complementary approaches: the ph dependence of the overall dissociation constant measured by an improved differential spectroscopic technique; the ph dependence of the enthalpy of complex formation measured by flow calorimetry; and the ph dependence of the number of protons released to, or taken up from, the solvent in the complex formation reacti ...	1986	3718928
the effect of co2 laser excision on local tumor recurrence.	this study was undertaken to determine the effect of co2 laser surgery on the incidence of local recurrence following tumor recurrence and to study the effect of "sterilization" of the operative site on this phenomenon. sixty fisher 344 rats were implanted with r323oac mammary carcinoma. animals were anesthetized with intraperitoneal pentobarbital, and all tumors were completely excised at 21 days postimplantation. the animals were randomized into groups of 12 as follows: group s underwent excis ...	1986	3724334
alleviation of estrogen-induced hyperprolactinemia through intracerebral transplantation of hypothalamic tissue containing dopaminergic neurons.	prolactin-secreting pituitary tumors can be induced in young rats through prolonged estrogen treatment. recent evidence suggests that such tumors are associated with a degeneration of tuberoinfundibular dopaminergic (ti-da) neurons, which normally inhibit prolactin secretion by the anterior pituitary's lactrophs. for this study, chronic hyperprolactinemia was induced in young, ovariectomized fisher 344 rats through silastic capsule implants of 17 beta-estradiol, placed subcutaneously for 1 month ...	1986	3736784
evaluation of the effects of photoradiation therapy on brain tumors with in vivo p-31 mr spectroscopy.	in vivo phosphorus-31 magnetic resonance (mr) spectra were obtained by a surface coil method from rat glioma tissue inoculated subcutaneously in cd fisher rats, and the effects of photoradiation therapy on tumors were evaluated by sequentially observing spectral changes. in the control group, the nucleoside triphosphate (ntp) and phosphomonoester peaks were large, the phosphocreatine peak was small, and the inorganic phosphate (pi) peak was intermediate. in all eight cases in the group in which ...	1986	3737923
normal-pressure hydrocephalus. onset of gait abnormality before dementia predicts good surgical outcome.	in 1977, fisher reported that in patients with possible normal-pressure hydrocephalus (nph), if the gait abnormality preceded dementia, surgery usually had a favorable outcome and vice versa. we studied this finding in 21 patients shunted for possible nph. by evaluating serial videotapes of gait, neuropsychological tests, and katz index ratings, preoperatively and at approximately two months and six months postoperatively, we judged 16 patients improved. in the improved group, the families repor ...	1986	3741212
elderly listeners' estimates of vocal age in adult females.	the purpose of this study was to provide data on the ability of elderly listeners to estimate the age group of women (25-35, 45-55, 70-80) from phonated and whispered vowel productions. further, comparisons were made between the performance of these elderly listeners and results for young listeners reported previously [s. e. linville and h. fisher, j. acoust. soc. am. 78, 40-48 (1985)]. tape recordings of whispered and normally phonated /ae/ vowels were played to 23 elderly women for relative ag ...	1986	3745688
clinical significance of serum and csf findings in the guillain-barré syndrome and related disorders.	clinical data and the serum and cerebrospinal fluid (csf) findings of 71 patients with guillain-barré syndrome (gbs), 7 with fisher syndrome and 24 with chronic inflammatory polyradiculoneuropathy (cip), were analysed. isoelectric focusing of serum and csf together with different formulae and diagrams were applied to study blood-csf barrier (bcb) function and possible intrathecal igg synthesis. the csf total protein concentration and its igg percentage depended mainly on the degree of bcb damage ...	1986	3746360