Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| role of viral infections in the induction of adverse drug reactions. | a spectrum of adverse drug reactions that are caused by the combined action of drugs and viruses has been described: ampicillin rash in acute infectious mononucleosis; reye's syndrome; hypersensitivity reactions to sulphonamides in patients with hiv infection; drug-induced agranulocytosis; paracetamol (acetaminophen) hepatotoxicity; aspirin (acetylsalicyclic acid)-induced asthma; epstein-barr virus-associated lymphoma and methotrexate; and aids-related kaposi's sarcoma and nitrite use. changes i ... | 1997 | 9010640 |
| drug treatment of hiv-related opportunistic infections. | the aids epidemic has led to the emergence of several disease entities which in the pre-aids era were rare or seemingly innocuous. experience of treating these diseases varies. in some instances, such as pneumocystis carinii pneumonia, there is an abundance of published literature to direct our course of action. however, for many of these newly recognised diseases our treatment experience is limited. furthermore, in many instances, well controlled trials evaluating treatment modalities in the ai ... | 1997 | 9010648 |
| a bcl-2 homolog encoded by kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with bax or bak. | the bcl-2 protein family is characterized by the ability to modulate cell death, and members of this family share two highly conserved domains called bcl-2 homology 1 (bh1) and 2 (bh2) which have been shown to be critical for the death-repressor activity of bcl-2 and bcl-xl. through sequence analysis we identified a novel viral bcl-2 homolog, designated ksbcl-2, from human herpesvirus 8 (hhv8) or kaposi sarcoma-associated herpesvirus. the overall amino acid sequence identity between ksbcl-2 and ... | 1997 | 9012846 |
| primary effusion burkitt's lymphoma with t(8;22) in a patient with hepatitis c virus-related cirrhosis. | hepatitis c virus (hcv) infection may be complicated by non-hodgkin's lymphoma through yet unknown pathogenetic mechanisms. we describe the case of a patient with hcv-related cirrhosis who developed a primary effusion lymphoma (pel) of burkitt's type confined to the peritoneal cavity, in the absence of immunodeficiency or autoimmunity. paracentesis followed by immunophenotyping, karyotyping, and molecular studies allowed us to diagnose a small noncleaved b-cell lymphoma (cd20+, cd24+, cd10+, cd5 ... | 1997 | 9013840 |
| circulating spindle cells: correlation with human herpesvirus-8 (hhv-8) infection and kaposi's sarcoma. | 1997 | 9014921 | |
| ophthalmic complications of hiv/aids. | as a result of improved treatment and patient survival, ophthalmic complications are now being seen with increasing frequency in aids, occurring in up to 75% of patients during the course of the disease. the eye may be involved by an aids-related microvasculopathy, which gives rise to cotton wool spots, and by opportunistic infections caused by a wide range of organisms, including cytomegalovirus, herpes simplex virus, varicella zoster, toxoplasma gondii, mycobacterium avium-intracellulare, trep ... | 1996 | 9015465 |
| the pharmacokinetics of tnp-470, a new angiogenesis inhibitor. | to characterize the pharmacokinetic profile of tnp-470, a synthetic analog of fumagillin that is a potent inhibitor of angiogenesis and inhibits neovascularization in several solid tumor models. | 1997 | 9017768 |
| the prevalence of serum antibody to human herpesvirus 8 (kaposi sarcoma-associated herpesvirus) among hiv-seropositive and high-risk hiv-seronegative women. | to determine the prevalence of human herpesvirus 8 (hhv-8) seropositivity among women who are known to be infected with human immunodeficiency virus type 1 (hiv-1) or who are at high risk for hiv infection. | 1997 | 9020272 |
| kaposi's sarcoma: is the hunt for the culprit over now? | patients suffering from the acquired immune deficiency syndrome (aids) have a 20000-fold increased risk of developing a severe form of kaposi's sarcoma (ks), a previously rare malignancy involving sharply defined nodular lesions of the skin and/or oral mucosa. epidemiological evidence has long suggested that an infectious agent is the probable cause of ks. recently sequences from a putative new herpesvirus have been found to be associated with ks in virtually 100% of the cases analyzed. the susp ... | 1997 | 9020381 |
| pathology of acquired immunodeficiency syndrome (aids) in children. | overview: acquired immunodeficiency syndrome (aids) was first described to occur in children in 1983. with experience of increasing number of cases of aids, pathologic lesions in various organs and tissues such as lungs, brain, g.i. tract, heart, blood vessels, lymph nodes, spleen, bone marrow, etc. became evident in autopsy and biopsy specimens. these pathologic lesions were classified into four groups based on known or suspected pathogenesis: 1) primary lesions due to human immunodeficiency (h ... | 1996 | 9023448 |
| [kaposi sarcoma and human herpes virus type 8: recent data]. | 1996 | 9026586 | |
| human herpesvirus-8/kaposi's sarcoma-associated herpesvirus in organ transplant patients with immunosuppression. | several recent studies have demonstrated kaposi's sarcoma-associated herpes virus (kshv), also known as putative human herpes virus-8 (hhv-8), dna in various epidemiologic forms of kaposi's sarcoma (ks), including aids-associated, classic, and endemic types. risk of developing ks in non-hiv-infected immunosuppressed hosts, such as patients following solid organ transplantation, is also significantly higher compared to normal individuals. we have retrospectively evaluated 28 organ transplant pati ... | 1997 | 9029034 |
| development of a quantitative competitive polymerase chain reaction for human herpesvirus 8. | a quantitative competitive polymerase chain reaction (pcr) assay for human herpesvirus 8 (hhv8) was developed. the assay uses a competitive internal control sequence which differs from the wild type sequence by the presence of an ecori restriction endonuclease site. the quantitative method was validated by co-amplifying known amounts of control sequence dna and wild type dna, and shown to accurately quantify hhv8 within the range of 10(1)-10(6) genome copies (r = 0.998). the assay was used to qu ... | 1997 | 9029526 |
| detection of human herpesvirus 8 dna in semen from hiv-infected individuals but not healthy semen donors. | to ascertain the prevalence of kaposi's sarcoma-associated herpesvirus (kshv), also known as human herpesvirus (hhv) type 8, and cytomegalovirus (cmv) dna in semen was investigated. | 1997 | 9030358 |
| human herpesvirus 8 in semen and prostate. | 1997 | 9030373 | |
| absence of human herpesvirus 8 sequences in prostate specimens. | 1997 | 9030389 | |
| viral lesions of the mouth in hiv-infected patients. | viral lesions of the mouth in patients with hiv infection are common and these diseases any be a marker for hiv and disease progression. we review the spectrum of oral viral manifestations and discuss treatment modalities. the most common epstein-barr virus (ebv)-induced disorder in hiv-infected patients is oral hairy leukoplakia. ebv-related oral b-cell and t-cell lymphoma in aids patients has been described repeatedly. herpes virus type 1 and rarely type 2 may lead to painful and resistant ora ... | 1997 | 9031782 |
| demonstration of herpes virus 8 in a lymphangioma-like kaposi's sarcoma occurring in a non-immunosuppressed patient. | 1997 | 9031806 | |
| a single 13-kilobase divergent locus in the kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genome contains nine open reading frames that are homologous to or related to cellular proteins. | two small fragments of a novel human gammaherpesvirus genome known as kaposi's sarcoma (ks)-associated herpesvirus or human herpesvirus 8 (hhv-8) have been shown to be present in virtually all aids and non-aids ks lesions, as well as in body cavity-based lymphomas (bcbl) and in multicentric castleman's disease. we have extended those studies by identifying and sequencing a third fragment of hhv-8 dna encoding a viral thymidylate synthetase (ts) gene. use of this viral ts fragment as a probe led ... | 1997 | 9032328 |
| kaposi's sarcoma-associated herpesvirus encodes a functional cyclin. | kaposi's sarcoma-associated herpesvirus (kshv) (also called human herpesvirus 8) is consistently found in kaposi's sarcoma lesions and in body-cavity-based lymphomas. a 17-kb kshv lambda clone was obtained directly from a kaposi's sarcoma lesion. dna sequence analysis of this clone identified an open reading frame which has 32% amino acid identity and 53% similarity to the virus-encoded cyclin (v-cyclin) of herpesvirus saimiri (hvs) and 31% identity and 53% similarity to human cellular cyclin d2 ... | 1997 | 9032330 |
| strain variability among kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genomes: evidence that a large cohort of united states aids patients may have been infected by a single common isolate. | previous analysis of the majority of kaposi's sarcoma (ks) tumors, in both aids and non-aids populations, has revealed the consistent presence of two small subsegments (open reading frame 25/26 [orf25/26] and orf75) of a novel human gamma class herpesvirus genome referred to as kshv or hhv-8. we have carried out dna sequence comparisons with dnas encompassing a total of 2,500 bp each over three separate pcr-amplified fragments from ks lesions and body cavity-based lymphoma (bcbl) samples from 12 ... | 1997 | 9032391 |
| childhood infections with human herpesviruses types 6, 7, and 8. | 1996 | 9033979 | |
| [is hvh-8 the etiologic agent for kaposi's sarcoma?]. | 1996 | 9035718 | |
| geographic and ethnic variations in the incidence of childhood cancer. | the total incidence of childhood cancer varies rather little between different regions of the world, with cumulative risk to age 15 nearly always in the range 1.0-2.5 per thousand. acute lymphoblastic leukaemia, especially in early childhood, is most common in populations of high socio-economic status and is the most frequent childhood cancer in all industrialised countries. the risk of burkitt's lymphoma is highest in tropical africa and papua new guinea; it is strongly associated with epstein- ... | 1996 | 9039726 |
| cancer incidence in a cohort of human immunodeficiency virus seroconverters. hiv italian seroconversion study group. | in addition to kaposi's sarcoma and non-hodgkin's lymphomas, it has been postulated that human immunodeficiency virus (hiv) infection may increase the risk of other cancers. the aim of the current study was to compare incidence rates of cancer among individuals who seroconverted for hiv infection with the rates in the general population of italy. | 1997 | 9041163 |
| presence of human herpesvirus 8 variants in the oral tissues of human immunodeficiency virus-infected persons. | a 210-bp dna segment specific to the human herpesvirus 8 (hhv-8) genome was amplified by nested polymerase chain reaction from 10 of 14 archived oral biopsy samples of hiv-positive patients in london who had no evidence of oral kaposi's sarcoma (ks). various oral sites were represented. oral tissues from 20 general dental patients not known to be hiv-infected were negative. when dna sequences of these products were compared with sequences derived from 5 oral ks tissues of aids patients in london ... | 1997 | 9041349 |
| human immunodeficiency virus-related lymphoid proliferations. | human immunodeficiency virus (hiv) infection is associated with a range of lymphoid alterations from generalized lymphadenopathy to abnormal lymphoid proliferations and malignant lymphomas. special characteristics of lymphoid proliferation are seen in the lungs and thymus of children infected with hiv. hiv-related lymphoid proliferations may be associated with other infectious agents including pneumocystis carinii, mycobacteria, rickettsial-like organisms, epstein-barr virus (ebv) and kaposi's s ... | 1997 | 9044509 |
| kaposi's sarcoma-associated herpesvirus: a lymphotropic human herpesvirus associated with kaposi's sarcoma, primary effusion lymphoma, and multicentric castleman's disease. | despite extensive epidemiological evidence suggesting that kaposi's sarcoma (ks) has an infectious origin, a specific viral association with ks had not been documented until recently, when two novel dna fragments were identified in ks lesional tissue from a patient with the acquired immunodeficiency syndrome (aids). these fragments belong to a previously unidentified human herpesvirus, called ks-associated herpesvirus (kshv), or human herpesvirus 8. although this virus is generally absent from n ... | 1997 | 9044510 |
| molecular pathology of acquired immunodeficiency syndrome-related non-hodgkin's lymphoma. | the incidence of non-hodgkin's lymphoma is greatly increased in human immunodeficiency virus (hiv)-infected individuals. most are clinically aggressive b-cell lymphomas exhibiting burkitt-type, immunoblastic or large-cell morphology. approximately 80% arise systemically (nodal or extranodal), and the remaining 20% arise in the central nervous system. a small proportion are body cavity-based (primary effusion) lymphomas associated with kaposi's sarcoma-associated herpesvirus (kshv) infection. pos ... | 1997 | 9044511 |
| [opportunistic lymphoma]. | malignant lymphoma is one of the most common complications in patients under immunodeficiency. such lymphomas, termed as opportunistic lymphoma, are growing in these days because of the high prevalence of aids and the wide introduction of organ/bone marrow transplantation. the epstein-barr virus has been regarded as the sole causative agent of this condition. recent studies, however, added another new virus, the kaposi's sarcoma-associated herpesvirus (kshv) as the second pathogen of this condit ... | 1997 | 9046838 |
| three new human herpesviruses (hhv6, 7, and 8). | three new human herpesviruses have been recognised in the past decade, and add further to our knowledge of human diseases with potential viral aetiologies. these viruses can be included with the other known human herpesviruses found in normal body secretions, particularly saliva. hhv6 and hhv7 have been associated with febrile illnesses and the childhood disease, exanthem subitum. hhv8 seems to resemble epstein-barr virus in its possible transforming properties and poses challenging questions fo ... | 1997 | 9048803 |
| kaposi's sarcoma-associated human herpesvirus-8 encodes homologues of macrophage inflammatory protein-1 and interleukin-6. | human herpesvirus-8 (hhv-8) has been detected in kaposi's sarcoma (ks) lesions of all types (aids-related, classical and endemic), in body-cavity-based b-cell lymphomas (bcbls) and in lesions of multicentric castleman's disease (mcd). we have identified a major gamma-herpesvirus-divergent locus (dl-b) in hhv-8 dna encoding several hhv-8 unique open reading frames (orfs), including a homologue of interleukin-6 (il-6) and two homologues of macrophage inflammatory protein mip-1. we show that the hh ... | 1997 | 9055855 |
| kaposi's sarcoma-associated herpesvirus encodes a functional bcl-2 homologue. | kaposi's sarcoma-associated herpesvirus (kshv) is a newly discovered herpesvirus etiologically associated with kaposi's sarcoma (ks) and two lymphoproliferative disorders. we describe a kshv vbcl-2 gene with homology to the proto-oncogene bcl-2. it is expressed in ks lesions and in cell lines derived from primary effusion lymphomas. using yeast and human cells we demonstrate the ability of kshv vbcl-2 protein to suppress bax toxicity. we show that kshv vbcl-2 heterodimerizes with human bcl-2 in ... | 1997 | 9055856 |
| glucocorticoids induce kaposi's sarcoma cell proliferation through the regulation of transforming growth factor-beta. | glucocorticoid (gc) use is known to induce or enhance the growth of kaposi's sarcoma (ks) in many clinical settings including human immunodeficiency virus infection, collagen vascular disease, lymphoproliferative disorders, and renal transplantation. because gcs may induce immune suppression and thus tumor growth, we determined whether gcs had a direct effect on ks growth. we found that gcs directly induce the growth of ks cell lines. in examining the mechanism of action of gcs, we did not obser ... | 1997 | 9057628 |
| is kaposi's sarcoma--associated herpesvirus ubiquitous in urogenital and prostate tissues? | controversy exists as to whether kaposi's sarcoma-associated herpesvirus (kshv) is more widespread than originally reported. recently, monini et al reported that kshv is ubiquitous in urogenital and prostate tissues and sperm of healthy italian adults using nested polymerase chain reaction (pcr). we have examined for the presence of kshv in 10 normal prostates from italian men and 10 from men from the united states, as well as 32 prostatic, 30 vulvar, 24 ovarian, 20 cervical, and 30 testicular c ... | 1997 | 9057651 |
| lack of evidence of hhv-8 dna in blood cells from heart transplant recipients. | 1997 | 9057673 | |
| infectious human herpesvirus 8 in a healthy north american blood donor. | molecular studies have provided strong evidence for the association of human herpesvirus 8 (hhv-8) with kaposi's sarcoma. these data have been supported by serological studies, which have also suggested that hhv-8 can be found in the healthy population. we report the presence of infectious hhv-8 in a healthy donor to a north american blood bank. | 1997 | 9057733 |
| identification, expression, and immunogenicity of kaposi's sarcoma-associated herpesvirus-encoded small viral capsid antigen. | we describe a recombinant antigen for use in serologic tests for antibodies to kaposi's sarcoma (ks)-associated herpesvirus (kshv). the cdna for a small viral capsid antigen (svca) was identified by immunoscreening of a library prepared from the bc-1 body cavity lymphoma cell line induced into kshv lytic gene expression by sodium butyrate. the cdna specified a 170-amino-acid peptide with homology to small viral capsid proteins encoded by the bfrf3 gene of epstein-barr virus and the orf65 gene of ... | 1997 | 9060668 |
| progressive loss of cd8+ t cell-mediated control of a gamma-herpesvirus in the absence of cd4+ t cells. | a unique experimental model has been developed for dissecting the integrity of cd8+ t cell-mediated immunity to a persistent gammaherpesvirus under conditions of cd4+ t cell deficiency. respiratory challenge of major histocompatibility complex class ii -/- and +/+ c57bl/6j mice with the murine gammaherpesvirus 68 (mhv-68) leads to productive infection of both lung and adrenal epithelial cells. virus titers peak within 5-10 d, and are no longer detected after day 15. persistent, latent infection ... | 1996 | 9064346 |
| [detection of herpes virus-like dna in various forms of kaposi's sarcoma but not in other mesenchymal tumors or inflammatory changes in skin]. | recently, herpes-virus like dna sequences defining a new herpes virus termed human herpes virus 8 (hhv8), were detected in kaposi's sarcoma of aids and non-aids patients. we describe the successful detection of hhv8 dna in archival skin biopsies of the various forms of kaposi's sarcoma. dna was extracted from archival skin biopsies of kaposi's sarcoma, other mesenchymal skin tumors and various inflammatory skin lesion of hiv seropositive and negative patients. the extracted dna was analyzed for ... | 1996 | 9065036 |
| opportunistic infections of the eye in immunocompromised patients. | all opportunistic infections of the eye have their origin in the suppression of the immune system of the host. the immunosuppression can be acquired through the human immune deficiency virus or as a result of immunosuppressive therapy in solid-organ transplant recipients with a maintenance therapy of cyclosporin and prednisone or during chemotherapy in patients with myeloproliferative disorders. generally, in less than 2% could severe opportunistic infections of the eye, like cytomegalovirus (cm ... | 1997 | 9065939 |
| detection of human herpes virus type 8 dna sequences as a valuable aid in the differential diagnosis of kaposi's sarcoma. | the occurrence of human herpes virus type 8 (hhv-8) dna sequences was evaluated by polymerase chain reaction in 36 cases of cutaneous kaposi's sarcoma (ks) (classic and associated with the acquired immunodeficiency syndrome) and in 88 pathologic entities that can histologically mimic ks, such as reactive and neoplastic vascular processes and lesions featuring focal or extensive spindle cell pattern. a positive reaction was detected in 16 (70%) of 23 samples of classic ks and 10 (77%) of 13 ks ca ... | 1997 | 9071724 |
| absence of kaposi's sarcoma associated herpesvirus-like dna sequences (kshv) in hiv-negative multicentric castleman's disease complicated by kshv-positive kaposi's sarcoma. | 1997 | 9074443 | |
| activation of hhv-8 by hiv-1 tat. | 1997 | 9074581 | |
| clearance of hhv-8 from peripheral blood mononuclear cells with a protease inhibitor. | 1997 | 9074582 | |
| [human herpesvirus 8 infections]. | 1997 | 9082436 | |
| detection of antibodies against viral capsid proteins of human herpesvirus 8 in aids-associated kaposi's sarcoma. | sequences of a new herpesvirus with homology to gammaherpesvirinae were recently identified in aids-associated kaposi's sarcoma (ks). subsequently this novel virus, called ks-associated virus (kshv) or human herpesvirus (hhv) 8 was detected in classical ks and aids-associated body cavity based lymphomas by polymerase chain reaction. in this report major and minor capsid proteins of hhv-8 were molecularly cloned and produced as recombinant proteins in escherichia coli. sera from 69 hiv-1 infected ... | 1997 | 9083932 |
| high incidence of kaposi's sarcoma-associated herpesvirus and epstein-barr virus in tumor lesions and peripheral blood mononuclear cells from patients with kaposi's sarcoma in uganda. | with the advent of aids, kaposi's sarcoma (ks) has become one of the leading malignancies in sub-saharan africa. recently, dna sequences from a new human herpesvirus called ks-associated herpesvirus (kshv) or human herpesvirus type 8 have been found in ks tumor lesions in high frequency. analyses of tumor lesions from 38 ugandan ks patients indicated a uniform presence of kshv in ks tumor lesions as revealed by polymerase chain reaction and southern hybridization. in contrast, only 31% (11/36) o ... | 1997 | 9086156 |
| viral flice-inhibitory proteins (flips) prevent apoptosis induced by death receptors. | viruses have evolved many distinct strategies to avoid the host's apoptotic response. here we describe a new family of viral inhibitors (v-flips) which interfere with apoptosis signalled through death receptors and which are present in several gamma-herpesviruses (including kaposi's-sarcoma-associated human herpesvirus-8), as well as in the tumorigenic human molluscipoxvirus. v-flips contain two death-effector domains which interact with the adaptor protein fadd, and this inhibits the recruitmen ... | 1997 | 9087414 |
| a novel family of viral death effector domain-containing molecules that inhibit both cd-95- and tumor necrosis factor receptor-1-induced apoptosis. | molluscum contagiosum virus proteins mc159 and mc160 and the equine herpesvirus 2 protein e8 share substantial homology to the death effector domain present in the adaptor molecule fas-associated death domain protein (fadd) and the initiating death protease fadd-like interleukin-1beta-converting enzyme (flice) (caspase-8). fadd and flice participate in generating the death signal from both tumor necrosis factor receptor-1 (tnfr-1) and the cd-95 receptor. the flow of death signals from tnfr-1 occ ... | 1997 | 9092488 |
| viral infections in human immunodeficiency virus disease. | a number of the herpesviruses as well as representatives of other viral genera can produce serious opportunistic infections in persons infected with hiv. although some, such as jc virus, hhv-6, and hhv-8, remain essentially untreatable at this time, others are readily treatable or can be retarded with chemoprophylaxis. further therapeutic advances for some of these viral superinfections, particularly cmv, hsv, vzv, hhv-8, and human genital papillomavirus, will considerably improve the longevity ... | 1997 | 9093235 |
| kaposi's sarcoma during immunosuppressive therapy for atopic dermatitis. | we describe an hiv-negative homosexual man who developed kaposi's sarcoma (ks). he had cd4 lymphocytopenia during azathioprine and topical corticosteroid therapy for atopic dermatitits (ad). ks was observed after only 2 months of immunosuppressive therapy. no regression was observed despite discontinuation of immunosuppressive therapy and normalization of the cd4+ cell count. this patient appears to be the first case of ks associated with ad. moreover, as our patient had been sexually inactive f ... | 1997 | 9094472 |
| identification of two homologs of the kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in retroperitoneal fibromatosis of different macaque species. | simian retroperitoneal fibromatosis (rf) is a vascular fibroproliferative neoplasm which has many morphological and histological similarities to human kaposi's sarcoma (ks). like epidemic ks in aids patients, rf is highly associated with an immunodeficiency syndrome (simian acquired immunodeficiency syndrome [saids]) caused by a retrovirus infection. recently, a new gammaherpesvirus, called kaposi's sarcoma-associated herpesvirus (kshv) or human herpesvirus 8 (hhv8), has been identified in ks tu ... | 1997 | 9094697 |
| isolated pulmonary microangiitis mimicking pneumonia in a patient infected with human immunodeficiency virus. | we describe the first case, to our knowledge, of apparently isolated pulmonary vasculitis mimicking bacterial pneumonia in a patient infected with human immunodeficiency virus (hiv). patients presenting with fever, cough, and pulmonary infiltrates present a diagnostic challenge. as a result of severe t cell mediated immunosuppression and humoral dysregulation, the differential diagnosis is diverse. one must consider both noninfectious and infectious etiologies. noninfectious etiologies such as p ... | 1997 | 9101514 |
| intralesional human chorionic gonadotropin for kaposi's sarcoma. | 1997 | 9102573 | |
| [pulmonary kaposi's sarcoma in a patient with the acquired immunodeficiency syndrome]. | cutaneous kaposi's sarcoma (ks) is a well-known manifestation of the acquired immunodeficiency syndrome, but pulmonary ks is very rare in japan. we encountered a 27-year-old japanese, homosexual man who had extensive pulmonary ks. he came to our hospital because of a cough and dyspnea. on admission, there were some small nodules on the skin, and examination of a biopsy specimen led to the diagnosis of ks. the test for the human immunodeficiency virus antibody was positive and the cd4+ cell count ... | 1997 | 9103865 |
| [virus-related neurological disorders complicating in compromised hosts]. | chance of opportunistic infections in hospitals is increasing year by year, because of the steady increase in the number of compromised hosts. opportunistic infections in the nervous system include fungal, protozoal, bacterial and viral infections. cytomegalovirus and herpes virus (hsv1 and hsv2) cause encephalitis, myelitis and radiculoneuritis. varicella-zoster virus (vzv) often causes herpes zoster, which sometimes disseminates when immunodeficiency is severe. vzv also causes encephalitis. pr ... | 1997 | 9103900 |
| visualization of human herpesvirus type 8 in kaposi's sarcoma by light and transmission electron microscopy. | human herpesvirus type 8 (hhv-8) has been associated with kaposi's sarcoma, body cavity-based lymphoma (bcbl), and multicentric castleman's disease through dna, in situ hybridization, and serologic studies. hhv-8 has been visualized only in hhv-8-positive/epstein-barr virus (ebv)-negative/ cytomegalovirus (cmv)-negative bcbl cell lines, but not in hhv-8-positive/ebv-negative/ cmv-negative kaposi's sarcoma lesions. | 1997 | 9108935 |
| human herpesvirus type 8 dna sequences in biological samples of hiv-positive and negative individuals in sicily. | to evaluate the circulation of a new human herpesvirus (hhv), hhv-8 or kaposi's sarcoma (ks)-associated herpesvirus in a geographical area where a high incidence rate of classical ks was already present before the appearance of the aids epidemic. | 1997 | 9108942 |
| kaposi's sarcoma and sex hormones. | 1997 | 9108954 | |
| corrected prevalence of kaposi's sarcoma (ks)-associated herpesvirus infection prior to onset of ks. | 1997 | 9110091 | |
| kaposi's sarcoma and its management in aids patients. recommendations from a scandinavian study group. | ks is the most frequent malignancy in homo/bisexual male aids patients, affecting more than 30% of these patients. ks may present itself as a few innocent cutaneous lesions or may show progression resulting in severe morbidity and mortality. approximately half of the patients may develop severe progressive disease. the prognosis of patients with progressive disease is poor, with a median survival of less than 6 months. there is no cure for aids-related ks, but several therapies are available for ... | 1997 | 9112290 |
| human herpes virus-8 dna in bronchoalveolar lavage samples from patients with aids-associated pulmonary kaposi's sarcoma. | kaposi's sarcoma (ks) is the most frequent aids-associated neoplasm, and often disseminates to visceral organs, including the lungs. an ante-mortem diagnosis of pulmonary ks is difficult. recently, dna sequences resembling a new human herpes virus (hhv-8), have been identified in various forms of ks. we hypothesized that these sequences are present in samples obtained by bronchoalveolar lavage (bal) in patients with pulmonary ks. utilizing a nested polymerase chain reaction (pcr), 7/12 bal cell ... | 1997 | 9112291 |
| perforation of the jejunum secondary to aids-related gastrointestinal kaposi's sarcoma. | intestinal perforation in human immunodeficiency virus-positive patients due solely to kaposi's sarcoma (ks) has rarely been described. a homosexual man with acquired immunodeficiency syndrome-related ks who presented with an acute abdomen is presented. he was found to have a jejunal perforation through a small ks lesion. there were no infectious organisms identified at the site of perforation. | 1997 | 9113797 |
| kaposi's sarcoma-associated herpesvirus-like dna sequences (kshv/hhv-8) in oral aids-kaposi's sarcoma: a pcr and clinicopathologic study. | recently, a new human herpesvirus (kshv/hhv-8) has been identified in classic, transplant, endemic, and aids kaposi's sarcoma that may be involved in the pathogenesis of kaposi's sarcoma. the purpose of this study was to evaluate oral aids-kaposi's sarcoma for detection of kshv/hhv-8 dna. dna extracted from 54 oral aids-kaposi's sarcoma lesions (47 initial, 7 postvinblastine treated), 5 non-kaposi's sarcoma hiv-positive lesions, and 3 non-kaposi's sarcoma hiv-negative lesions was evaluated by po ... | 1997 | 9117759 |
| absence of kaposi's sarcoma-associated human herpes virus 8 in transplantation-related tumors other than kaposi's sarcoma. | 1997 | 9123547 | |
| characterization of a chemokine receptor-related gene in human herpesvirus 8 and its expression in kaposi's sarcoma. | human herpesvirus 8 (hhv-8) is a recently discovered, virus that is highly associated with kaposi's sarcoma (ks) and aids-associated body cavity lymphomas, although it is also found in some normal individuals. hhv-8 is related by nucleotide sequence homology to herpesvirus saimiri (hvs), which causes t cell lymphomas in some new world monkeys, and to epstein-barr virus (ebv), a human herpesvirus linked etiologically with burkitt's lymphoma and nasopharyngeal carcinoma. we report that, like hvs b ... | 1997 | 9123844 |
| risk of kaposi's sarcoma and oroanal sexual contact. | after contradictory findings from a number of previous studies, behavioral risk factors for kaposi's sarcoma were examined in a case-control study of 202 people diagnosed with acquired immunodeficiency syndrome (aids) in 1991-1993 in sydney, australia. cases comprised 67 men who developed kaposi's sarcoma at or after a diagnosis of acquired immunodeficiency syndrome, and controls were 135 people who did not have kaposi's sarcoma at the time of diagnosis of acquired immunodeficiency syndrome or d ... | 1997 | 9125993 |
| lack of evidence of any association between human herpesvirus 8 and various skin tumors from both immunocompetent and immunosuppressed patients. | 1997 | 9126020 | |
| rare presence of human herpesvirus 8 in skin tumors from patients with psoriasis treated with oral psoralen plus uv-a. | 1997 | 9126021 | |
| detection of serum antibodies to a kaposi's sarcoma-associated herpesvirus-specific peptide. | kaposi's sarcoma (ks)-associated herpesvirus/human herpesvirus type 8 (kshv/hhv-8) may play an etiologic role in the pathogenesis of ks. in an attempt to assess kshv/hhv-8 infection, an elisa was developed using an 18-amino acid peptide from a putative minor capsid protein of kshv/hhv-8 conjugated to bovine serum albumin. overall, sera from human immunodeficiency virus type 1 (hiv-1)-positive patients with ks had a higher reactivity in the assay than did sera from hiv-1-positive patients without ... | 1997 | 9129068 |
| analysis of human herpesvirus type 8 infection in aids-related and aids-unrelated primary central nervous system lymphoma. | human herpesvirus type 8 (hhv-8) has been proposed as a pathogenetic factor for immunosuppression-associated primary central nervous system lymphoma (pcnsl). to verify this hypothesis, hhv-8 infection was investigated in 31 persons with pcnsl (16 aids-related, 15 aids-unrelated) and in 30 persons with systemic b cell non-hodgkin's lymphomas (b-nhl; 15 aids-related, 15 aids-unrelated). all subjects with pcnsl scored negative by single-step polymerase chain reaction (pcr), suggesting a tumor virus ... | 1997 | 9129084 |
| exacerbations of clinical symptoms in human immunodeficiency virus type 1-infected patients with multicentric castleman's disease are associated with a high increase in kaposi's sarcoma herpesvirus dna load in peripheral blood mononuclear cells. | the epidemiologic link between multicentric castleman's disease (mcd) and kaposi's sarcoma (ks) and the high frequency of ks herpesvirus (kshv) detection in both diseases raise the question of a role of this new virus in the pathogenesis of mcd. to explore this hypothesis, the kshv dna load was investigated in peripheral blood mononuclear cells of 3 human immunodeficiency virus (hiv)-infected patients with mcd at different points during the clinical course. clinical parameters, such as fever and ... | 1997 | 9129085 |
| infection with aids-related herpesviruses in human immunodeficiency virus-negative infants and endemic childhood kaposi's sarcoma in africa. | novel herpesviruses have been described recently. these include human herpesviruses 6, 7 and 8 (hhv-6, -7, -8). hhv-6 has at least two strain groups, variants a and b. the b strains are predominant in the west and can account for over 97% of infections in infants. in contrast, the a strains are rare and the few well-characterized isolates have been from adult african aids patients. it is not clear whether the hhv-6 variant a strains are aids-related and/or whether they can also be acquired as ch ... | 1997 | 9129658 |
| blood donations and viruses. | 1997 | 9142091 | |
| high prevalence of cutaneous viral infections in aids patients with kaposi's sarcoma: insight into the role of human herpesvirus 8? | 1997 | 9143620 | |
| human herpesvirus 8 in classic kaposi sarcoma. | recent studies suggest the role of a new human herpesvirus (hhv8) in the pathogenesis of different forms of kaposi sarcoma (ks). in the present work we investigated the presence of hhv8 sequences in ks tumour tissues from patient with classic ks. since clear evidences point to the role of immune suppression in the development of aids-associated ks or patients receiving immunosuppressive therapy, immunological investigations were also performed. we could show a highly consequent association of hh ... | 1996 | 9147730 |
| does hiv tat protein also regulate genes of other viruses present in hiv infection? | 1997 | 9149528 | |
| antibodies to human herpesvirus 8 in women and infants born in haiti and the usa. | 146 hiv-1-positive pregnant women and 143 matched hiv-1-uninfected pregnant women participated in a study to assess the association of human herpes virus 8 (hhv8) and the development of kaposi's sarcoma. 98 of the 189 evaluable infants born to the women were born to hiv-1-positive mothers; 26 of these 98 infants were infected with hiv-1. maternal serum samples were available for all but 18. the sera were diluted and screened for antibodies to the hhv8 latency-associated nuclear antigens (lana ... | 1997 | 9149705 |
| sensitivity of kaposi's sarcoma-associated herpesvirus replication to antiviral drugs. implications for potential therapy. | using a cell line (termed bcbl-1) derived from a peripheral effusion (body cavity-based) lymphoma latently infected with kaposi's sarcoma-associated herpesvirus (kshv), we recently reported the successful induction of kshv replication in culture (renne, r., w. zhong, b. herndier, m. mcgrath, n. abbey, d. kedes, and d. ganem. 1996. nat. med. 2:342-346). here we report the first use of this system for establishing the susceptibility of kshv to available antiviral drugs. latently infected bcbl-1 ce ... | 1997 | 9151779 |
| cell-homologous genes in the kaposi's sarcoma-associated rhadinovirus human herpesvirus 8: determinants of its pathogenicity? | 1997 | 9151804 | |
| the cyclin encoded by kaposi's sarcoma-associated herpesvirus stimulates cdk6 to phosphorylate the retinoblastoma protein and histone h1. | kaposi's sarcoma-associated herpesvirus (kshv or human herpesvirus 8) is a novel gammaherpesvirus implicated in the cause of kaposi's sarcoma and certain malignancies of lymphatic origin. one of the candidate genes possibly involved in promoting tumor development is an open reading frame (orf) with sequence similarity to human type d cyclin genes. this cyclin-like gene, when expressed in tissue culture cells, promotes phosphorylation and inactivation of the retinoblastoma tumor suppressor protei ... | 1997 | 9151805 |
| open reading frame 26 of human herpesvirus 8 encodes a tetradecanoyl phorbol acetate- and butyrate-inducible 32-kilodalton protein expressed in a body cavity-based lymphoma cell line. | dna sequences corresponding to a novel herpesvirus (human herpesvirus 8 [hhv8]) are associated with kaposi's sarcoma (ks), castleman's disease, and body cavity-based lymphomas (bcbl). studies of a bcbl-derived cell line suggest a direct correlation between seropositivity against antigens specifically present in such lines and the development of ks. we have generated recombinant proteins corresponding to open reading frame (orf) 26 of hhv8 and have produced affinity-purified antibodies. using the ... | 1997 | 9151873 |
| hhv-8 and aids-related cns lymphoma. | human herpesvirus 8 (hhv-8), the kaposi's sarcoma (ks)-associated herpesvirus, is closely related to the transforming epstein-barr virus (ebv) and may be detected in aids-related, ebv-containing, body-cavity-based lymphomas. accordingly, we analyzed 27 ebv-positive, aids-related cns lymphomas for hhv-8 sequences. only one tumor yielded hhv-8 sequences; this tumor arose in a patient with concomitant systemic lymphoma and a history of ks. we conclude that hhv-8 is unlikely to have a major role in ... | 1997 | 9153468 |
| human herpesvirus type-8 (hhv-8) in haematopoietic neoplasia. | human herpesvirus type-8 (hhv-8) is a lymphotropic herpesvirus originally identified in kaposi's sarcoma. among lymphoproliferative disorders, hhv-8 infection is restricted to body-cavity-based lymphoma (bcbl) and multicentric castleman's disease (mcd). bcbl are b-cell lymphomas growing in liquid phase in the body cavities and most frequently associated with aids. bcbl express indeterminate phenotypes, in all cases are associated with hhv-8 infection, and frequently carry epstein-barr virus geno ... | 1997 | 9156655 |
| radiation therapy for malignancies in the setting of hiv disease. | with the introduction of increasingly effective antiretroviral agents for the management of aids, the life expectancy of appropriately treated patients will continue to lengthen as will the length of time during which infected patients amy develop malignancies, both hiv-related and non-hiv-related. the management of such patients will require careful consideration of the impact of all oncologic therapy on the immune system's ability to hold the virus at bay. radiation therapy, with its recognize ... | 1997 | 9159795 |
| functional characterization and modulation of cytokine production by cd8+ t cells from human immunodeficiency virus-infected individuals. | cd8+ t-cell clones were generated from peripheral blood mononuclear cells (pbmc) of three human immunodeficiency virus (hiv)-seronegative individuals and six hiv-seropositive individuals and assessed for their cytokine secretion profile, cytolytic potential, and chemokine production. while the great majority of cd8+ t-cell clones generated from hiv-seronegative individuals produced interferon (ifn)-gamma, but not interleukin-4 (il-4), that is a type 1 cytotoxic (tc1) profile, high numbers of cd8 ... | 1997 | 9160672 |
| a new human herpesvirus as a factor in the pathogenesis of kaposi's sarcoma and body-cavity lymphoma. | 1997 | 9161777 | |
| kaposi's-sarcoma-associated herpesvirus is detected in peripheral blood mononuclear cells of hiv-infected homosexuals more often than in heterosexuals. | the kaposi's-sarcoma-associated herpesvirus is thought likely to play an important part in the pathogenesis of kaposi's sarcoma, which is the most common tumor in aids patients. to determine whether peripheral blood is also infected by the virus, we prospectively tested mononuclear cells from hiv-infected individuals, both with and without kaposi's sarcoma. | 1997 | 9161780 |
| molecular heterogeneity of b-lineage diffuse large cell lymphoma. | b-lineage diffuse large cell lymphoma (b-dlcl) arising de novo is characterized by a marked degree of clinical heterogeneity. to determine whether or not the clinical heterogeneity of de novo b-dlcl is reflected by heterogeneity in the molecular features of these tumors, we investigated the pattern of distribution of several genetic lesions in 70 cases of de novo b-dlcl at diagnosis. the panel of genetic lesions tested comprised the molecular alterations most frequently detected in b-dlcl, inclu ... | 1996 | 9162193 |
| human herpesvirus 8 in kaposi's sarcoma of an hiv-negative japanese woman with adult t-cell leukemia. | 1997 | 9163629 | |
| clinical and pharmacokinetic study of oral etoposide in patients with aids-related kaposi's sarcoma with no prior exposure to cytotoxic therapy. | in this phase ii and pharmacokinetic study, chronic, low-dose, oral etoposide was evaluated for its efficacy in patients with aids-related kaposi's sarcoma who were not previously exposed to cytotoxic therapy. | 1997 | 9164226 |
| absence of human herpesvirus 8 genomes in coronary atherosclerosis in immunocompetent patients. | human herpevirus 8 (hhv8) has been localized to the endothelial and spindle cells of ks, suggesting a role for hhv8 in atherosclerosis. none of the 38 coronary atherectomy specimens contained hhv8 with both sensitive nested pcr assays, making it unlikely that persistent viral infection with hhv8 plays a role in coronary atherogenesis in the general population of the united states. | 1997 | 9164895 |
| malignancies in uk children with hiv infection acquired from mother to child transmission. | by april 1995, 302 cases of vertically acquired hiv infection had been reported through the british paediatric association surveillance unit. over 50% of these children had developed an aids indicator disease, including nine malignancies (seven cases of non-hodgkin's lymphoma (nhl) and two of kaposi's sarcoma). there were two other malignancies that were not aids indicator diseases. in children less than 5 years of age the incidence of nhl was approximately 2500 times greater than expected in th ... | 1997 | 9166025 |
| utility of fine needle aspiration in hiv-positive patients with corresponding cd4 counts. four years' experience in a large inner city hospital. | to assess the utility of fine needle aspiration (fna) in human immunodeficiency virus (hiv)-positive patients with corresponding cd4 count analysis. | 1997 | 9167706 |
| hiv-1 tat induces the expression of the interleukin-6 (il6) gene by binding to the il6 leader rna and by interacting with caat enhancer-binding protein beta (nf-il6) transcription factors. | human immunodeficiency virus type 1 (hiv-1) infection is associated with severe psoriasis, b cell lymphoma, and kaposi's sarcoma. a deregulated production of interleukin-6 (il6) has been implicated in the pathogenesis of these diseases. the molecular mechanisms underlying the abnormal il6 secretion of hiv-1-infected cells may include transactivation of the il6 gene by hiv-1. here we report the molecular mechanisms of tat activity on the expression of the il6 gene. by using 5' deletion mutants of ... | 1997 | 9169458 |
| post-transplantation kaposi's sarcoma appearing simultaneously in same cadaver donor renal transplant recipients. | 1997 | 9175072 | |
| kaposi's sarcoma in liver transplant recipients on fk506: two case reports. | we report two cases of kaposi's sarcoma (ks) after orthotopic liver transplantation for cirrhosis of the liver related to hepatitis c virus. both cases were saudi-born arabs who were negative for human immunodeficiency virus; one patient was receiving fk506 plus prednisolone, and the other patient was receiving fk506. one patient died of fulminant multicentric ks. the other patient, with lesions confined to the lower limbs, is still alive. these are the first case reports of ks in liver transpla ... | 1997 | 9175820 |
| study of hhv-8 in primary sjögren's syndrome. | 1997 | 9177933 | |
| detection of human herpes virus 8 dna and sequence polymorphism in classical, epidemic, and iatrogenic kaposi's sarcoma in south africa. | the aetiology and detection of human herpes virus type 8 (hhv-8) dna sequences in kaposi's sarcoma (ks) is a matter of intense investigation. we report on the detection of hhv-8 dna and sequence polymorphism in different clinicopathological subtypes of cutaneous ks samples from south africa. the diagnosis was confirmed by histological examination in all cases. six patients had classic ks (cks), 3 epidemic ks (eks), and 3 iatrogenic ks (iks). a nested polymerase chain reaction (pcr) assay was use ... | 1997 | 9179764 |