Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| microflora and periodontal disease. | periodontitis is a disease that affects and destroys the tissues that support teeth. tissue damage results from a prolonged inflammatory response to an ecological shift in the composition of subgingival biofilms. three bacterial species that constitute the red complex group, porphyromonas gingivalis, tannerella forsythia, and treponema denticola, are considered the main pathogens involved in periodontitis. | 2012 | 23814584 |
| pathogen levels and clinical response to periodontal treatment in patients with interleukin 8 haplotypes. | the aim of this study was to investigate the effect of non-surgical treatment of periodontitis on the levels of periodontopathogens and clinical parameters in patients with different genetic backgrounds produced by polymorphisms in the interleukin ( il8) gene. thirty patients grouped according to il8 atc/ttc or agt/ttc haplotypes were submitted to non-surgical periodontal treatment. levels of porphyromonas gingivalis, tannerella forsythia, and treponema denticola were determined in 240 subgingiv ... | 2013 | 23821559 |
| quantification of key periodontal pathogens in insulin-dependent type 2 diabetic and non-diabetic patients with generalized chronic periodontitis. | periodontitis is a common problem in patients with diabetes mellitus (dm), however, differences in the putative periodontal pathogens in subjects with dm compared to non-dm subjects are still inconclusive. the red complex, which includes porphyromonas gingivalis, treponema denticola, and tannerella forsythia, encompasses the most important pathogens in adult periodontal disease. the aim of the present study was to compare cell numbers of p. gingivalis, t. denticola, t. forsythia and aggregatibac ... | 2013 | 23827459 |
| multilevel analysis of bacterial counts from chronic periodontitis after root planing/scaling, surgery, and systemic and local antibiotics: 2-year results. | to follow changes (over 2 years) in subgingival bacterial counts of five microbial complexes including health-related actinomyces spp. in deeper pockets (≥5 mm) after periodontal treatments. | 2013 | 23853701 |
| characterization of periodontal biofilm in down syndrome patients: a comparative study. | the aim of this study was to characterize the main periodontal bacterial species in down syndrome (ds) patients with and without periodontitis. | 2013 | 23855174 |
| occurrence of red complex microorganisms and aggregatibacter actinomycetemcomitans in patients with diabetes. | the aim of the present study was to analyze the occurrence of porphyromonas gingivalis (p. gingivalis), tannerella forsythia (t. forsythia), treponema denticola (t. denticola), and aggregatibacter actinomycetemcomitans (a. actinomycetemcomitans) in patients with diabetes. | 2015 | 23857867 |
| molecular microbiological evaluation of subgingival biofilm sampling by paper point and curette. | the present clinical study aimed to investigate if there are differences in microbiological outcomes dependent on the subgingival biofilm collection method. subgingival biofilm samples were collected from the four deepest pockets (>5 mm) of 17 patients with aggressive periodontitis (agp) and 33 patients with chronic periodontitis (cp), first by paper point and thereafter by curette. samples obtained with the same method were pooled together from each patient and forwarded for molecular microbiol ... | 2014 | 23879704 |
| a simple mutagenesis using natural competence in tannerella forsythia. | we report the discovery of natural competence in tannerella forsythia and its application to targeted chromosomal mutagenesis. keeping t. forsythia in a biofilm throughout the procedure allowed efficient dna uptake and allelic replacement. this simple method is cost-effective and reproducible compared with the conventional protocols using broth culture and electroporation. | 2013 | 23892061 |
| the association between detectable plasmatic human immunodeficiency virus (hiv) viral load and different subgingival microorganisms in brazilian adults with hiv: a multilevel analysis. | this study investigates the association between detectable plasmatic human immunodeficiency virus (hiv) viral load (hvl) and high levels of periodontal- and non-periodontal-related microorganisms in the subgingival microbiota of individuals with hiv. | 2014 | 23952074 |
| porphyromonas gingivalis and treponema denticola synergistic polymicrobial biofilm development. | chronic periodontitis has a polymicrobial biofilm aetiology and interactions between key bacterial species are strongly implicated as contributing to disease progression. porphyromonas gingivalis, treponema denticola and tannerella forsythia have all been implicated as playing roles in disease progression. p. gingivalis cell-surface-located protease/adhesins, the gingipains, have been suggested to be involved in its interactions with several other bacterial species. the aims of this study were t ... | 2013 | 23990979 |
| oral microflora and periodontal disease: new technology for diagnosis in dentistry. | periodontitis is a disease that affects and destroys the tissues that support teeth. tissues damage results from a prolonged inflammatory response to an ecological shift in the composition of subgingival biofilms. three bacterial species that constitute the red complex group, porphyromonas gingivalis, tannerella forsythia, and treponema denticola, are considered the main pathogens involved in periodontitis. in the present study a real-time pcr based assay was designed to detect and quantify red ... | 2013 | 23991267 |
| protein substrates of a novel secretion system are numerous in the bacteroidetes phylum and have in common a cleavable c-terminal secretion signal, extensive post-translational modification, and cell-surface attachment. | the secretion of certain proteins in porphyromonas gingivalis is dependent on a c-terminal domain (ctd). after secretion, the ctd is cleaved prior to extensive modification of the mature protein, probably with lipopolysaccharide, therefore enabling attachment to the cell surface. in this study, bioinformatic analyses of the ctd demonstrated the presence of three conserved sequence motifs. these motifs were used to construct hidden markov models (hmms) that predicted 663 ctd-containing proteins i ... | 2013 | 24007199 |
| progression of periodontal inflammation in adolescents is associated with increased number of porphyromonas gingivalis, prevotella intermedia, tannerella forsythensis, and fusobacterium nucleatum. | the study aims to evaluate the change of related subgingival periodontopathogens among different stage of gingivitis in adolescent and assess the relationship between periodontopathogens and the progression of periodontal inflammation. | 2014 | 24025042 |
| detection of putative periodontopathic bacteria in type 1 diabetic and healthy children: a comparative study. | the aim of this study was to compare and assess the risk of periodontitis due to the presence of four putative periodontopathic bacteria (porphyromonas gingivalis, treponema denticola, tannerella forsythia, and aggregatibacter actinomycetemcomitans) in type 1 diabetic and healthy children. | 2013 | 24025882 |
| occurrence of periodontal pathogens among patients with chronic periodontitis. | the aim of the present study was to evaluate the presence of the periodontal pathogens that form the red complex (tannerella forsythia, porphyromonas gingivalis and treponema denticola) and aggregatibacter actinomycetemcomitans in patients with chronic periodontitis. the sample consisted of 29 patients with a clinical and radiographic diagnosis of chronic periodontitis based on the criteria of the american academy of periodontology (3). samples for microbiological analysis were collected from th ... | 2012 | 24031906 |
| the effects of stress hormones on growth of selected periodontitis related bacteria. | the focus of this study was to examine in vitro the effects of stress hormones (catecholamines: epinephrine, norepinephrine, dopamine and hydrocortisone: cortisol) on the growth of four anaerobic species of periodontitis-related bacteria (fusobacterium nucleatum, porphyromonas gingivalis, prevotella intermedia and tannerella forsythia) and one facultative anaerobic species (eikenella corrodens). bacterial growth was determined by two different methods: fluorescence in situ hybridization (fish), ... | 2013 | 24036419 |
| quantitative analysis of periodontal pathogens present in the saliva of geriatric subjects. | at present, information regarding periodontal disease in geriatric patients is scarce. the purpose of this study was to quantify the periodontal pathogens present in the saliva of korean geriatric patients and assess the relationship between the bacterial levels and the periodontal condition. | 2013 | 24040571 |
| characterizing the s-layer structure and anti-s-layer antibody recognition on intact tannerella forsythia cells by scanning probe microscopy and small angle x-ray scattering. | tannerella forsythia is among the most potent triggers of periodontal diseases, and approaches to understand underlying mechanisms are currently intensively pursued. a ~22-nm-thick, 2d crystalline surface (s-) layer that completely covers tannerella forsythia cells is crucially involved in the bacterium-host cross-talk. the s-layer is composed of two intercalating glycoproteins (tfsa-gp, tfsb-gp) that are aligned into a periodic lattice. to characterize this unique s-layer structure at the nanom ... | 2013 | 24089361 |
| inter-bacterial correlations in subgingival biofilms: a large-scale survey. | although the complexity of the oral ecology and the ecological differences between health and disease are well accepted, a clear view on the dynamics in relation to disease is lacking. in this study, the prevalence and abundance of 20 key oral bacteria was assessed in health and disease and more importantly a closer look was given to the inter-bacterial relationships. | 2014 | 24102517 |
| determination of periodontopathogens in patients with cri du chat syndrome. | cri du chat syndrome is a genetic alteration associated with some oral pathologies. however, it has not been described previously any clinical relationship between the periodontal disease and the syndrome. the purpose of this comparative study was to compare periodontopathogenic flora in a group with cri du chat syndrome and another without the síndrome, to assess a potential microbiological predisposition to suffer a periodontitis. | 2013 | 24121919 |
| microbial analysis of subgingival plaque samples compared to that of whole saliva in patients with periodontitis. | the detection of special bacterial species in patients with periodontitis is considered to be useful for clinical diagnosis and treatment. the collection of subgingival plaque samples is the common way for the determination of periodontopathic bacteria. however, recently, salivary analysis has been discussed as an advantageous future diagnostic method for periodontitis because it offers simple quantitative sampling and the possibility to assess various bacteria. the aim of this cross-sectional s ... | 2014 | 24144271 |
| protein-linked glycans in periodontal bacteria: prevalence and role at the immune interface. | protein modification with complex glycans is increasingly being recognized in many pathogenic and non-pathogenic bacteria, and is now thought to be central to the successful life-style of those species in their respective hosts. this review aims to convey current knowledge on the extent of protein glycosylation in periodontal pathogenic bacteria and its role in the modulation of the host immune responses. the available data show that surface glycans of periodontal bacteria orchestrate dendritic ... | 2013 | 24146665 |
| oxantel disrupts polymicrobial biofilm development of periodontal pathogens. | bacterial pathogens commonly associated with chronic periodontitis are the spirochete treponema denticola and the gram-negative, proteolytic species porphyromonas gingivalis and tannerella forsythia. these species rely on complex anaerobic respiration of amino acids, and the anthelmintic drug oxantel has been shown to inhibit fumarate reductase (frd) activity in some pathogenic bacteria and inhibit p. gingivalis homotypic biofilm formation. here, we demonstrate that oxantel inhibited p. gingival ... | 2014 | 24165189 |
| microbiological effect of essential oils in combination with subgingival ultrasonic instrumentation and mouth rinsing in chronic periodontitis patients. | thirty chronic periodontitis patients were randomly assigned to 3 groups: control, saline, and essential oil-containing antiseptic (eo). subgingival plaque was collected from a total of 90 pockets across all subjects. subsequently, subgingival ultrasonic instrumentation (sui) was performed by using eo or saline as the irrigation agent. after continuous mouth rinsing at home with eo or saline for 7 days, subgingival plaques were sampled again. periodontopathic bacteria were quantified using the m ... | 2013 | 24171000 |
| microbial changes in subgingival plaque and polymicrobial intracellular flora in buccal cells after fixed orthodontic appliance therapy: a preliminary study. | the oral ecosystem is strictly related to a balance maintained by specific niches recognized as sites, where oral bacteria can metabolize avoiding the immune system response. the oral bacteria species that colonize the ecological niches vary during fixed orthodontic treatment, with a prevalence of periodontal bacterial species. qualitative analysis of five periodontal pathogens was used to investigate the microbial colonization rate in the crevice and buccal epithelial cells. the presence of ina ... | 2013 | 24223591 |
| oral hygiene reinforcement in the simplified periodontal treatment of 1 hour. | to compare the clinical and microbiological outcome of the 1-h ultrasonic debridement of chronic periodontitis patients (cpp) with and without frequent sessions of oral hygiene reinforcement. | 2014 | 24255993 |
| association of plasma 25-hydroxyvitamin d concentrations and pathogenic oral bacteria in postmenopausal females. | previous findings of an association between 25-hydroxyvitamin d [25(oh)d] concentrations and periodontal disease may be partially explained by the antimicrobial properties of vitamin d. to the best of the authors' knowledge, no study has investigated the association between 25(oh)d and pathogenic oral bacteria, a putative cause of periodontal disease. | 2013 | 24261910 |
| oral status in patients with early rheumatoid arthritis: a prospective, case-control study. | patients with ra suffer from a higher risk of periodontal attachment loss and increased oral inflammation. we hypothesize that there are pathogenetic and immunological interactions between these diseases that go beyond impaired manual dexterity accompanying advanced ra. the primary objective of the present study was to determine whether a loss of alveolar bone can be detected in ra patients during the early course of the disease. | 2014 | 24273047 |
| bacterial cell-envelope glycoconjugates. | prokaryotic glycosylation fulfills an important role in maintaining and protecting the structural integrity and function of the bacterial cell wall, as well as serving as a flexible adaption mechanism to evade environmental and host-induced pressure. the scope of bacterial and archaeal protein glycosylation has considerably expanded over the past decade(s), with numerous examples covering the glycosylation of flagella, pili, glycosylated enzymes, as well as surface-layer proteins. this article a ... | 2013 | 24274370 |
| the influence of oral bacteria on epithelial cell migration in vitro. | oral ulcerations often arise as a side effect from chemo- and radiation therapy. in a previous clinical study, porphyromonas gingivalis was identified as a positive predictor for oral ulcerations after hematopoetic stem cell transplantation, possibly incriminating p. gingivalis in delayed healing of the ulcerations. therefore, it was tested whether p. gingivalis and its secreted products could inhibit the migration of oral epithelial cells in an in vitro scratch assay. to compare, the oral bacte ... | 2013 | 24288439 |
| [relationships of five periodontal pathogens causing subgingival plaque in patients with chronic periodontitis under different periodontal conditions]. | this study aimed to assess the relationship between the distributions of haemophilus aggregatibacter (h. aggregatibacter ), porphyromonas gingivalis (p. gingivalis ), prevotella intermedia (p. intermedia), tannerella forsythensis (t. forsythensis), and treponema denticola (t. denticola) in subgingival plaque and different periodontal conditions of chronic periodontitis. | 2013 | 24298807 |
| biology and pathogenesis of cytomegalovirus in periodontal disease. | human periodontitis is associated with a wide range of bacteria and viruses and with complex innate and adaptive immune responses. porphyromonas gingivalis, tannerella forsythia, aggregatibacter actinomycetemcomitans, treponema denticola, cytomegalovirus and other herpesviruses are major suspected pathogens of periodontitis, and a combined herpesvirus-bacterial periodontal infection can potentially explain major clinical features of the disease. cytomegalovirus infects periodontal macrophages an ... | 2014 | 24320955 |
| interleukin-8 responses of multi-layer gingival epithelia to subgingival biofilms: role of the "red complex" species. | periodontitis is an infectious inflammatory disease that results in the destruction of the tooth-supporting (periodontal) tissues. the gram-negative anaerobic species porphyromonas gingivalis, tannerella forsythia and treponema denticola, (also known as the "red complex" species) are highly associated with subgingival biofilms at periodontitis-affected sites. a major chemokine produced by the gingival epithelium in response to biofilm challenge, is interleukin (il)-8. the aim of this in vitro st ... | 2013 | 24339946 |
| impact of early colonizers on in vitro subgingival biofilm formation. | the aim of this study was to investigate the impact of early colonizing species on the structure and the composition of the bacterial community developing in a subgingival 10-species biofilm model system. the model included streptococcus oralis, streptococcus anginosus, actinomycesoris, fusobacterium nucleatum subsp. nucleatum, veillonella dispar, campylobacter rectus, prevotella intermedia, porphyromonas gingivalis, tannerella forsythia, and treponema denticola. based on literature, we consider ... | 2013 | 24340084 |
| the effects of different orthodontic appliances upon microbial communities. | orthodontic appliances can promote accumulation of dental plaque, with associated enamel decalcification or gingival inflammation. the aim of this study was to examine longer-term microbiological changes during orthodontic treatment with fixed appliances. | 2014 | 24345204 |
| structural and functional characterization of nanu, a novel high-affinity sialic acid-inducible binding protein of oral and gut-dwelling bacteroidetes species. | many human-dwelling bacteria acquire sialic acid for growth or surface display. we identified previously a sialic acid utilization operon in tannerella forsythia that includes a novel outer membrane sialic acid-transport system (nanou), where nano (neuraminate outer membrane permease) is a putative tonb-dependent receptor and nanu (extracellular neuraminate uptake protein) is a predicted susd family protein. using heterologous complementation of nanou genes into an escherichia coli strain devoid ... | 2014 | 24351045 |
| periodontal bacteria in the genital tract: are they related to adverse pregnancy outcome? | one of the most important factors implicated in preterm birth (ptb) is acute genitourinary tract infection. the bacteria causing chronic periodontal inflammation include gram-negative rods and anaerobes similar to those found in women with bacterial vaginosis. the aim of this prospective study is to investigate the relationship between oral and vaginal microflora and preterm low birth weight. real-time polymerase chain reaction was used to detect both the presence and level of six periodontitis- ... | 2017 | 24355228 |
| tannerella forsythia bspa increases the risk factors for atherosclerosis in apoe(-/-) mice. | the aim of this study was to evaluate the effects of tannerella forsythia and its major surface virulence factor, bspa, on the progression of atherosclerosis in apoe(-/-) mice and the expression of lipid metabolism-related genes. | 2014 | 24372897 |
| the effect of locally delivered doxycycline in the treatment of chronic periodontitis. a clinical and microbiological cohort study. | to evaluate the efficacy of locally delivered doxycycline as an adjunct to non-surgical treatment with the use of an ultrasonic device compared to scaling and root planing using hand instruments, by means of clinical and microbiological criteria. | 2010 | 24421978 |
| periodontal disease associated with red complex bacteria in dogs. | red complex bacteria (treponema denticola, tannerella forsythia and porphyromonas gingivalis) play a major role in the aetiology of periodontal disease in humans. this study was designed to evaluate the association of such bacteria with periodontal disease in dogs. | 2014 | 24450418 |
| in vivo effectiveness of silicone gel sheets as barriers at the inner microgap between a prosthetic abutment and an external-hexagon implant platform. | bacterial penetration and colonization of the microgap at the implant-abutment interface have been reported in several studies. the aim of this study was to evaluate the effectiveness of placing a silicone membrane between the abutment and the implant platform in an attempt to seal the interface. | 2014 | 24451862 |
| in vitro-activity of oily calcium hydroxide suspension on microorganisms as well as on human alveolar osteoblasts and periodontal ligament fibroblasts. | findings from animal and human studies have indicated that an oily calcium hydroxide suspension (ochs) may improve early wound healing in the treatment of periodontitis. calcium hydroxide as the main component is well known for its antimicrobial activity, however at present the effect of ochs on the influence of periodontal wound healing/regeneration is still very limited. the purpose of this in vitro study was to investigate the effect of ochs on periodontopathogenic bacteria as well as on the ... | 2014 | 24475753 |
| 16s rdna-based metagenomic analysis of dental plaque and lung bacteria in patients with severe acute exacerbations of chronic obstructive pulmonary disease. | acute exacerbations of chronic obstructive pulmonary disease (ae-copd) are leading causes of mortality in hospital intensive care units. we sought to determine whether dental plaque biofilms might harbor pathogenic bacteria that can eventually cause lung infections in patients with severe ae-copd. | 2014 | 24484531 |
| quantification of periodontal pathogens in vascular, blood, and subgingival samples from patients with peripheral arterial disease or abdominal aortic aneurysms. | the aim of this investigation is to quantify periodontal pathogens (aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, campylobacter rectus, and tannerella forsythia) in vascular, blood, and subgingival samples. as a secondary objective, two molecular bacterial identification methods (nested polymerase chain reaction [pcr] and quantitative pcr [qpcr]) are compared. | 2014 | 24502612 |
| transcriptional responses of treponema denticola to other oral bacterial species. | the classic organization by socransky and coworkers categorized the oral bacteria of the subgingival plaque into different complexes. treponema denticola, porphyromonas gingivalis and tannerella forsythia are grouped into the red complex that is highly correlated with periodontal disease. socransky's work closely associates red with orange complex species such as fusobacterium nucleatum and prevotella intermedia but not with members of the other complexes. while the relationship between species ... | 2014 | 24505483 |
| single cell genomics of uncultured, health-associated tannerella bu063 (oral taxon 286) and comparison to the closely related pathogen tannerella forsythia. | the uncultivated bacterium tannerella bu063 (oral taxon 286) is the closest relative to the periodontal pathogen tannerella forsythia, but is not disease-associated itself. using a single cell genomics approach, we isolated 12 individual bu063 cells by flow cytometry, and we amplified and sequenced their genomes. comparative analyses of the assembled genomic scaffolds and their gene contents allowed us to study the diversity of this taxon within the oral community of a single human donor that pr ... | 2014 | 24551246 |
| subgingival plaque sampling after combined mechanical and antibiotic nonsurgical periodontal therapy. | this study aimed to make a comparison of two sampling strategies of subgingival plaque after combined mechanical-antibiotic periodontal therapy. | 2015 | 24554003 |
| prevelance of periodontopathogenic bacteria in subgingival biofilm and atherosclerotic plaques of patients undergoing coronary revascularization surgery. | the objective of the present study was to detect the presence of specific periodontopathogenic bacteria in the coronary plaque of patients with coronary artery disease and to find out the significant association between the periodontal status and the presence of pathogenic bacteria in the coronary plaque. | 2013 | 24554879 |
| [dissertations 25 years after date 37. susceptibility to periodontal diseases]. | in the eighties of the former century it was observed that individuals had different modes of development of periodontitis, largely for unknown reasons. it was assumed that periodontal disease developed as a result of the presence of virulent micro-organisms in combination with an inadequate host response. the concept of this (im)balance in host parasite interactions developed further, in part because of new research techniques. with respect to oral bacteria it was shown that periodontal pathoge ... | 2013 | 24555252 |
| pathogens and host immunity in the ancient human oral cavity. | calcified dental plaque (dental calculus) preserves for millennia and entraps biomolecules from all domains of life and viruses. we report the first, to our knowledge, high-resolution taxonomic and protein functional characterization of the ancient oral microbiome and demonstrate that the oral cavity has long served as a reservoir for bacteria implicated in both local and systemic disease. we characterize (i) the ancient oral microbiome in a diseased state, (ii) 40 opportunistic pathogens, (iii) ... | 2014 | 24562188 |
| clinical and microbiological effects of levofloxacin in the treatment of chronic periodontitis: a randomized, placebo-controlled clinical trial. | the aim of the present study was to evaluate the clinical and microbiological effect of systemic levofloxacin (lfx) as an adjunct to scaling and root planing (srp) in patients with chronic periodontitis (cp). | 2015 | 24574052 |
| bacteria community study of combined periodontal-endodontic lesions using denaturing gradient gel electrophoresis and sequencing analysis. | the entire microbial population and predominant microflora of root canals (rcs) and adjacent periodontal pockets (pps) from teeth with combined periodontal-endodontic lesions were determined and compared. | 2014 | 24579762 |
| bis-enoxacin blocks rat alveolar bone resorption from experimental periodontitis. | periodontal diseases are multifactorial, caused by polymicrobial subgingival pathogens, including porphyromonas gingivalis, treponema denticola, and tannerella forsythia. chronic periodontal infection results in inflammation, destruction of connective tissues, periodontal ligament, and alveolar bone resorption, and ultimately tooth loss. enoxacin and a bisphosphonate derivative of enoxacin (bis-enoxacin) inhibit osteoclast formation and bone resorption and also contain antibiotic properties. our ... | 2014 | 24638087 |
| microbiological assessment of the implant-abutment interface in different connections: cross-sectional study after 5 years of functional loading. | to evaluate the bacterial microflora present inside the implant connection and in the peri-implant sulcus fluid of healthy implants, and to analyze the relationships between these harboring sites for four different implant systems after at least 5 years of functional loading. | 2015 | 24665919 |
| ancient human oral plaque preserves a wealth of biological data. | a new study explores the ancient oral microbiome from the well-preserved dental calculus samples of four human individuals who lived during medieval times, using a suite of genomic, proteomic and microscopic approaches. the authors investigate the evolution of dental pathogens by reconstructing the genome of the periodontal pathogen tannerella forsythia and also identify antibiotic resistance genes, bacterial virulence factors and host immune defense proteins. | 2014 | 24675519 |
| oral cavity anaerobic pathogens in biofilm formation on voice prostheses. | a polymerase chain reaction (pcr)-based method has been used to identify oral anaerobic pathogens in biofilms on voice prostheses. the purpose of the present study was to determine the location of those pathogens inside the biofilms. | 2015 | 24677258 |
| presence of oral bacterial species in primary endodontic infections of primary teeth. | knowledge of the microbial composition of deciduous endodontic infections is limited. this study aimed to evaluate the presence of the 10 oral bacterial species in samples from primary tooth root canals by using microarray technology and to determine the association of these organisms with clinical conditions. | 2013 | 24683780 |
| [clinical and microbiological effects of the initial periodontal therapy]. | periodontitis is a destructive inflammatory disease of the tooth-supporting tissues, primarily caused by gram-negative microorganisms. thus, the primary objective of cause-related initial periodontal therapy is disruption and removal of the subgingival biofilm. | 2014 | 24684025 |
| periodontal pathogens and associated factors in aggressive periodontitis: results 5-17 years after active periodontal therapy. | to assess the association between presence of periodontal pathogens and recurrence of disease in patients with aggressive periodontitis (agp) after active periodontal therapy (apt) and further influencing factors. | 2014 | 24708362 |
| assessment of periodontal and opportunistic flora in patients with peri-implantitis. | to assess the presence of periodontal and opportunistic organisms in patients with peri-implantitis. | 2015 | 24720498 |
| genetic characteristics and pathogenic mechanisms of periodontal pathogens. | periodontal disease is caused by a group of bacteria that utilize a variety of strategies and molecular mechanisms to evade or overcome host defenses. recent research has uncovered new evidence illuminating interesting aspects of the virulence of these bacteria and their genomic variability. this paper summarizes some of the strategies utilized by the major species - aggregatibacter actinomycetemcomitans, tannerella forsythia, treponema denticola, and porphyromonas gingivalis - implicated in the ... | 2014 | 24736700 |
| porphyromonas gingivalis: major periodontopathic pathogen overview. | porphyromonas gingivalis is a gram-negative oral anaerobe that is involved in the pathogenesis of periodontitis and is a member of more than 500 bacterial species that live in the oral cavity. this anaerobic bacterium is a natural member of the oral microbiome, yet it can become highly destructive (termed pathobiont) and proliferate to high cell numbers in periodontal lesions: this is attributed to its arsenal of specialized virulence factors. the purpose of this review is to provide an overview ... | 2014 | 24741603 |
| detection and quantification of periodontal pathogens in smokers and never-smokers with chronic periodontitis by real-time polymerase chain reaction. | the purpose of the present investigation is to compare the presence and number of periodontal pathogens in the subgingival microbiota of smokers versus never-smokers with chronic periodontitis and matched probing depths (pds) using real-time polymerase chain reaction (rt-pcr). | 2014 | 24794687 |
| epstein-barr virus associated peri-implantitis: a split-mouth study. | herpesviral-bacterial synergism may play a potential role in periodontitis and peri-implantitis (pi) etiopathogenesis. pi lesions can worsen depending on specific microbial challenge and host susceptibility. this cross-sectional split-mouth study aimed to substantiate herpesviral-bacterial co-infection in pi patients and assess associations with periodontopathogen salivary contamination. | 2015 | 24802631 |
| relationship between expression of human gingival beta-defensins and levels of periodontopathogens in subgingival plaque. | human beta-defensins (hbds) are a group of antimicrobial peptides important in epithelial innate immunity, and their differential expression is associated with periodontal diseases. the aim of this study was to explore relationships among hbds, total subgingival bacteria and periodontopathogens in healthy subjects and in patients with chronic periodontitis. | 2015 | 24814979 |
| evaluation of periodontal pathogens of the mandibular third molar pericoronitis by using real time pcr. | the aim of this study was to investigate the mandibular third molar pericoronitis flora by using real-time polymerase chain reaction (pcr). | 2014 | 24835305 |
| clinical and microbiological characterization of localized aggressive periodontitis: a cohort study. | localized aggressive periodontitis (lagp) is an infectious periodontal disease which generally affects young people. recent data suggest the involvement of different bacterial species in different populations. the causative bacterial species in israel has never been identified despite a high prevalence of lagp in this population. the objectives of this study were to characterize the bacterial microbiota of periodontal pockets within an israeli lagp population who were also clinically assessed. | 2014 | 24861390 |
| internal bacterial colonization of implants: association with peri-implant bone loss. | the aim of the present longitudinal study was to investigate bacterial colonization of the internal implant cavity and to evaluate a possible association with peri-implant bone loss. | 2015 | 24861845 |
| comparison of culture and polymerase chain reaction techniques in the identification of tannerella forsythia in periodontal health and disease, an in vitro study. | various bacterial species from subgingival biofilm have demonstrated aetiological relevance in the initiation and progression of periodontitis. the aim of this study was to detect the presence of tannerella forsythia (tf) in subgingival plaque of periodontally healthy subjects and chronic periodontitis patients by using both culture and pcr technique and compare the two techniques. | 2014 | 24872621 |
| [effect of er:yag laser on the dynamic changes in subgingival flora in type 2 diabetic patients with periodontitis]. | to observe the changes in subgingival microflora before and after er:yag laser treatment on diabetic patients with periodontitis, and to compare with the subgingival microflora of chronic periodontitis. | 2014 | 24881214 |
| association between periodontal disease and plasma levels of cholesterol and triglycerides. | untreated periodontal disease seems to cause low grade systemic inflammation and blood lipid alteration leading to increased cardiovascular disease risk. to start testing this hypothesis in colombian patients, a multicentre study was conducted including the three main state capitals: bogota, medellin and cali. | 2013 | 24892452 |
| expression and regulation of triggering receptor expressed on myeloid cells 1 in periodontal diseases. | periodontitis is an inflammatory infectious disease that destroys the tooth-supporting tissues. it is caused by multi-species subgingival biofilms that colonize the tooth surface. porphyromonas gingivalis, treponema denticola and tannerella forsythia (i.e. 'red complex' bacteria) are characteristic subgingival biofilm species. the triggering receptor expressed on myeloid cells 1 (trem-1) is a cell surface receptor of the immunoglobulin superfamily, with a role in the amplification of proinflamma ... | 2014 | 24924298 |
| the s-layer proteins of tannerella forsythia are secreted via a type ix secretion system that is decoupled from protein o-glycosylation. | conserved c-terminal domains (ctd) have been shown to act as a signal for the translocation of certain proteins across the outer membrane of bacteroidetes via a type ix secretion system (t9ss). the genome sequence of the periodontal pathogen tannerella forsythia predicts the presence of the components for a t9ss in conjunction with a suite of ctd proteins. t. forsythia is covered with a two-dimensional crystalline surface (s-) layer composed of the glycosylated ctd proteins tfsa and tfsb. to inv ... | 2014 | 24943676 |
| periodontal pathogens in atheromatous plaque. | there has been increasing attention paid in recent years to the possibility that oral bacterial infection, particularly periodontal disease may influence the initiation and or progression of systemic diseases. these studies confirm the observation that heart disease is the most commonly found systemic condition in patients with periodontal disease. moreover, the literature has also highlighted substantial evidence indicating the presence of gram-negative periodontal pathogens in atheromatous pla ... | 2014 | 24943760 |
| antibacterial activities of extracts from ugandan medicinal plants used for oral care. | medicinal plants are widely used for treatment of oral/dental diseases in uganda. | 2014 | 24945400 |
| the influence of orthodontic fixed appliances on the oral microbiota: a systematic review. | to investigate whether there is scientific evidence to support the hypothesis that the presence of orthodontic fixed appliances influences the oral microbiota. | 2014 | 24945514 |
| oral inflammation, tooth loss, risk factors, and association with progression of alzheimer's disease. | periodontitis is a polymicrobial chronic inflammatory disease of tooth-supporting tissues with bacterial etiology affecting all age groups, becoming chronic in a subgroup of older individuals. periodontal pathogens porphyromonas gingivalis, tannerella forsythia, and treponema denticola are implicated in the development of a number of inflammatory pathologies at remote organ sites, including alzheimer's disease (ad). the initial inflammatory hypothesis proposed that ad hallmark proteins were the ... | 2014 | 24946875 |
| colonisation of gingival epithelia by subgingival biofilms in vitro: role of "red complex" bacteria. | biofilm formation on tooth surface results in colonisation and invasion of the juxtaposed gingival tissue, eliciting strong inflammatory responses that lead to periodontal disease. this in vitro study investigated the colonisation of human gingival multi-layered epithelium by multi-species subgingival biofilms, and evaluated the relative effects of the "red complex" species (porphyromonas gingivalis, tannerella forsythia and treponema denticola). | 2014 | 24949828 |
| identification of microbial pathogens in periodontal disease and diabetic patients of south indian population. | periodontitis have been referred to as the sixth complication of diabetes found in high prevalence among diabetic patients than among healthy controls. the aim of the present study was to examine the periodontal disease status among collected dental plaque samples. chromosomal dna was isolated and amplified by universal primers. the dna was sequenced for bacterial confirmation and phylogenetic analysis performed for the evolutionary relationship with other known pathogens. no amplification produ ... | 2014 | 24966528 |
| glycobiology aspects of the periodontal pathogen tannerella forsythia. | glycobiology is important for the periodontal pathogen tannerella forsythia, affecting the bacterium's cellular integrity, its life-style, and virulence potential. the bacterium possesses a unique gram-negative cell envelope with a glycosylated surface (s-) layer as outermost decoration that is proposed to be anchored via a rough lipopolysaccharide. the s-layer glycan has the structure 4‑meo-b-manpnacconh2-(1→3)-[pse5am7gc-(2→4)-]-b-manpnaca-(1→4)-[4-meo-a-galp-(1→2)-]-a-fucp-(1→4)-[-a-xylp-(1→3 ... | 2012 | 24970146 |
| influence of the periodontal status on the initial-biofilm formation on titanium surfaces. | dental implants will be exposed to a complex ecosystem once they are placed in the oral cavity. the bacterial colonization and biofilm formation on these devices will depend not only on the physicochemical surface implant properties but also on the periodontal health conditions of the patients, as these devices are exposed. | 2016 | 24995517 |
| lack of a surface layer in tannerella forsythia mutants deficient in the type ix secretion system. | tannerella forsythia, a gram-negative anaerobic bacterium, is an important pathogen in periodontal disease. this bacterium possesses genes encoding all known components of the type ix secretion system (t9ss). t. forsythia mutants deficient in genes orthologous to the t9ss-encoding genes pork, port and sov were constructed. all pork, port and sov single mutants lacked the surface layer (s-layer) and expressed less-glycosylated versions of the s-layer glycoproteins tfsa and tfsb. in addition, thes ... | 2014 | 25023245 |
| quantitative analysis of classical and new putative periodontal pathogens in subgingival biofilm: a case-control study. | a number of species/phylotypes have been newly implicated as putative periopathogens. the objective of this study was to explore associations among classical and new pathogens in subgingival biofilm and to assess their relative importance to chronic periodontitis. | 2015 | 25040261 |
| bioinformatic investigation of the cost management strategies of five oral microbes. | some amino acids are more energetically costly to synthesize de novo, therefore many microbes have evolved to regulate the metabolic expenditure of the cell and reduce the energy burden of extracellular unrecyclable proteins. several oral bacterial species take up amino acids and peptides obtained from proteolysis of host proteins and hence do not rely only on de novo synthesis. the aim of this study was to investigate if five oral bacterial species implement cost management strategies to reduce ... | 2015 | 25052707 |
| effect of repeated adjunctive antimicrobial photodynamic therapy on subgingival periodontal pathogens in the treatment of chronic periodontitis. | the aim of this study was to compare the effect of subgingival ultrasonic scaling followed by repeated (three times) antimicrobial photodynamic therapy (pdt), ultrasonic scaling alone (us), and scaling and root planing with hand instruments (srp) for initial periodontal treatment. twenty-seven non-smoking systemically healthy chronic periodontitis patients were included. residual pockets ≥4 mm deep and bleeding on probing were debrided either with srp, us alone, or us followed by a single episod ... | 2015 | 25056413 |
| active invasion of porphyromonas gingivalis and infection-induced complement activation in apoe-/- mice brains. | periodontal disease is a polymicrobial inflammatory disease that leads to chronic systemic inflammation and direct infiltration of bacteria/bacterial components, which may contribute to the development of alzheimer's disease. apoe-/- mice were orally infected (n = 12) with porphyromonas gingivalis, treponema denticola, tannerella forsythia, and fusobacterium nucleatum as mono- and polymicrobial infections. apoe-/- mice were sacrificed following 12 and 24 weeks of chronic infection. bacterial gen ... | 2015 | 25061055 |
| periodontopathogens and human β-defensin-2 expression in gingival crevicular fluid from patients with periodontal disease in guangxi, china. | periodontal diseases are often induced by periodontopathogens, which are always exposed to certain innate immune factors in gingival crevicular fluid, including human β-defensin-2 (hbd-2). this study aims to investigate the relationship among periodontopathogens, clinical parameters and hbd-2 expression. | 2015 | 25065393 |
| igg sera levels against a subset of periodontopathogens and severity of disease in aggressive periodontitis patients: a cross-sectional study of selected pocket sites. | to evaluate the association among serum immunoglobulin g (igg) responses to aggregatibacter actinomycetemcomitans (aa) serotypes a, b and c, porphyromonas gingivalis (pg), tannerella forsythia (tf) and clinical parameters in aggressive periodontitis (ap) subjects. associations between periodontal pathogens and clinical and immunological parameters were also evaluated. | 2014 | 25070874 |
| reducing the bioactivity of tannerella forsythia lipopolysaccharide by porphyromonas gingivalis. | tannerella forsythia is considered a pathogen of periodontitis and forms a biofilm with multi-species bacteria in oral cavity. lipopolysaccharide is a powerful immunostimulator and induces inflammation and shock. the purpose of this study was to investigate the characteristics of t. forsythia lps in its co-cultivation with fusobacterium nucleatum or porphyromonas gingivalis. t. forsythia was co-cultured in the presence and absence of f. nucleatum and p. gingivalis and then t. forsythia lps was e ... | 2014 | 25098564 |
| periodontitis in rats induces systemic oxidative stress that is controlled by bone-targeted antiresorptives. | periodontitis is a chronic, polymicrobial inflammatory disease that degrades connective tissue and alveolar bone and results in tooth loss. oxidative stress has been linked to the onset of periodontal tissue breakdown and systemic inflammation, and the success of antiresorptive treatments will rely on how effectively they can ameliorate periodontal disease-induced oxidative stress during oral infection. | 2015 | 25101489 |
| microbial signature profiles of periodontally healthy and diseased patients. | to determine microbial profiles that discriminate periodontal health from different forms of periodontal diseases. | 2014 | 25139407 |
| dentilisin involvement in coaggregation between treponema denticola and tannerella forsythia. | periodontitis arises from a biofilm consisting of gram-negative anaerobic rods and spirochetes. porphyromonas gingivalis, treponema denticola, and tannerella forsythia, termed the red complex, have been co-isolated with high frequency from chronic periodontitis lesions, and these microorganisms are thought to be major pathogens of the disease. coaggregation is an important strategy in the colonization of dental plaque biofilm by these bacteria. in the present study, we investigated the coaggrega ... | 2014 | 25152229 |
| comparative genome analysis and identification of competitive and cooperative interactions in a polymicrobial disease. | polymicrobial diseases are caused by combinations of multiple bacteria, which can lead to not only mild but also life-threatening illnesses. periodontitis represents a polymicrobial disease; porphyromonas gingivalis, treponema denticola and tannerella forsythia, called 'the red complex', have been recognized as the causative agents of periodontitis. although molecular interactions among the three species could be responsible for progression of periodontitis, the relevant genetic mechanisms are u ... | 2014 | 25171331 |
| periodontal bacteria in human carotid atherothrombosis as a potential trigger for neutrophil activation. | epidemiological, biological and clinical links between periodontal and cardiovascular diseases are now well established. several human studies have detected bacterial dna corresponding to periodontal pathogens in cardiovascular samples. intraplaque hemorrhage has been associated with a higher risk of atherosclerotic plaque rupture, potentially mediated by neutrophil activation. in this study, we hypothesized that plaque composition may be related to periodontal pathogens. | 2014 | 25173070 |
| a pathogenic trace of tannerella forsythia - shedding of soluble fully active tumor necrosis factor α from the macrophage surface by karilysin. | tannerella forsythia is implicated as a pathogen causing chronic and aggressive periodontitis. however, its virulence factors, including numerous putative proteases, are mostly uncharacterized. karilysin is a newly described matrix metalloprotease-like enzyme of t. forsythia. since pathogen-derived proteases may affect the host defense system via modulation of the cytokine network, the aim of this study was to determine the influence of karilysin on tumor necrosis factor-α (tnf-α). the results s ... | 2014 | 25175980 |
| the presence of cariogenic and periodontal pathogens in the oral cavity of one-year-old infants delivered pre-term with very low birthweights: a case control study. | recently, the dental literature has focused mainly on the microbial colonization of healthy full-term infants and their mothers or caretakers. however, oral microbial acquisition by premature infants has not been adequately investigated, and the correlation between pre-term birth and the presence of cariogenic and periodontal pathogens has not been determined. the aim of this study was to identify the presence and quantities of representative cariogenic and periodontal pathogens in the oral cavi ... | 2014 | 25178742 |
| [comparison of the effects of ginkgo biloba extract and minocycline hydrochlovide on periodontitis]. | to compare the clinical effect of ginkgo biloba extract gel (ginkgo biloba extract,egb) and minocycline hydrochloride (periocline) on periodontitis and their inhibition on putative periodontal pathogens. | 2014 | 25199931 |
| real-time pcr quantification of six periodontal pathogens in saliva samples from healthy young adults. | the use of saliva as a diagnostic fluid for the evaluation of periodontal health has gained attention recently. most published real-time pcr assays focused on quantification of bacteria in subgingival plaque, not in saliva. the aims of this study were to develop a real-time pcr assay for quantification of six periodontal pathogens in saliva and to establish a relationship between the amount of dna (fg) and colony-forming unit (cfu). | 2015 | 25217278 |
| neutrophil mobilization by surface-glycan altered th17-skewing bacteria mitigates periodontal pathogen persistence and associated alveolar bone loss. | alveolar bone (tooth-supporting bone) erosion is a hallmark of periodontitis, an inflammatory disease that often leads to tooth loss. periodontitis is caused by a select group of pathogens that form biofilms in subgingival crevices between the gums and teeth. it is well-recognized that the periodontal pathogen porphyromonas gingivalis in these biofilms is responsible for modeling a microbial dysbiotic state, which then initiates an inflammatory response destructive to the periodontal tissues and ... | 2014 | 25225799 |
| association between polycystic ovary syndrome, oral microbiota and systemic antibody responses. | polycystic ovary syndrome (pcos) is a hormonal disorder of women that not only is the leading cause of infertility but also shows a reciprocal link with oral health. this study aimed to investigate the hypothesis that the levels of putative periodontal pathogens in saliva and their antibody response in serum are elevated in pcos, compared to systemic health. a total of 125 women were included in four groups; 45 women with pcos and healthy periodontium, 35 women with pcos and gingivitis, 25 syste ... | 2014 | 25232962 |