Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| evidence for a multiple innervation of cerebellar purkinje cells by climbing fibers in adult ferrets infected at birth by a mink enteritis virus. | newborn ferrets were inoculated with mink enteritis virus (parvovirus). they developed a cerebellar hypoplasia and presented severe ataxia. electrophysiological study by intracellular recordings in the cerebellar cortex demonstrates that in these ferrets, like in other mammals, purkinje cells deprived from granule cell input during development remain multiply innervated by climbing fibers in the adult. | 1987 | 3040186 |
| influenza infection causes airway hyperresponsiveness by decreasing enkephalinase. | ferret tracheal segments were infected with human influenza virus a/taiwan/86 (h1n1) in vitro. after 4 days, the smooth muscle contractile responses to acetylcholine and to substance p were measured. the response to substance p was markedly accentuated, with a threefold increase in force of contraction at a substance p concentration of 10(-5) m, the highest concentration tested. in contrast, the response to acetylcholine was not affected by viral infection. histological examination of tissues re ... | 1988 | 3042736 |
| action of a novel drug (zy 16039) on mucus secretion in the ferret isolated trachea in vitro. | 1. the effect of 4-h-2-carboxamido-4-phenyl-thieno-[3,2c]-[1]-benzopyran (zy 16039) was examined on the smooth muscle contraction, mucus secretion and albumin transudation in the ferret whole trachea in vitro. 2. zy 16039 (0.1-20 microm) produced a concentration-dependent relaxation of the ferret trachea contracted by methacholine (1 microm) and phenylephrine (10 microm). the relaxations were about 20% of the full contractions. 3. zy 16039 has no effect on the resting (zero) output of mucus in t ... | 1988 | 3044031 |
| pruritus in rabbits, rodents, and ferrets. | this article attempts to cover the more specific pruritic problems encountered in rabbits, rodents, and ferrets. there are certainly other causes of pruritus in these animals. dermatophytes in guinea pigs are not reported to be pruritic, but because they are pruritic in other species, they should be considered in a differential diagnosis. a cryptococcal dermatitis in a guinea pig that was pruritic has been reported. although mites were not seen on scraping, the animal was treated for sarcoptid m ... | 1988 | 3055647 |
| organization of primary visual cortex (area 17) in the ferret. | anatomical and electrophysiological mapping techniques were used to determine topographic organization and arrangement of ocular dominance columns in the primary visual cortex of ferrets. from its border with area 18 on the posterior lateral gyrus, area 17 extends around the caudal pole of the hemisphere and over the splenial gyrus to the caudal bank of the splenial sulcus. the visuotopic map is oriented with the isoazimuth lines approximately parallel to the long axis of the posterior lateral g ... | 1988 | 3068264 |
| [vaccination of ferrets (putorius furo) against rabies using a tissue vaccine]. | the use of live tissue rabies vaccine from vnukovo-32 strain produced by the bioveta national corporation at ivanovice na hané was tested on 15 ferrets (putorius furo l. 1758). the 21st day after subcutaneous application of 3 ml of vaccine, the average titre of virus-neutralizing antibodies was 1 : 71.4, and after subcutaneous and intramuscular application of 1 ml of vaccine the average titre was 1:20.6 and 1 : 15.6, respectively. the challenge test was performed 52 weeks after vaccination: a do ... | 1986 | 3083568 |
| acute effects of gnrf-induced gonadotrophin secretion upon ovarian steroid secretion in the ferret. | the effects of an increase in endogenous gonadotrophin secretion on the production of oestradiol, progesterone, androstenedione and testosterone by the ovaries of anaesthetized anoestrous and oestrous ferrets were followed. gonadotrophin secretion was enhanced by the injection of gonadotrophin releasing factor (gnrf), and serial blood samples were collected over 9 h for hormone assay. thyrotrophic hormone releasing factor (trf) or acetic acid were injected for control purposes. the plasma conten ... | 1986 | 3083626 |
| pulpal response to an experimental adhesion promoter. | the pulpal response to an experimental adhesion promoter (ptp) used in conjunction with a composite resin material, biogloss, is described, in lined and unlined cavities. dycal was the lining and negative control material. standardised class v cavities were prepared in ferret canine teeth and the pulpal responses studied after 1, 2 and 4 weeks and 6 months post-operatively. pre-treatment of cavities with ptp causes a reduction in pulpal inflammation at 7 and 14 days compared with biogloss. there ... | 1986 | 3088234 |
| penetration in vitro of human and ferret dentine by three bacterial species in relation to their potential role in pulpal inflammation. | 1986 | 3108162 | |
| intracellular free calcium concentration measured with 19f nmr spectroscopy in intact ferret hearts. | changes in the intracellular free ca2+ concentration, [ca2+]i, mediate excitation-contraction coupling in the heart and contribute to cellular injury during ischemia and reperfusion. to study these processes directly, we measured [ca2+]i in perfused ferret (mustela putorius furo) hearts using 19f nmr spectroscopy to detect the 5,5'-difluoro derivative of the ca2+ chelator 1,2-bis(o-aminophenoxy)ethane-n,n,n',n'-tetraacetic acid (bapta). to load cells, hearts were perfused with the acetoxymethyl ... | 1987 | 3112778 |
| the action of dazopride to enhance gastric emptying and block emesis. | the substituted benzamide derivatives, dazopride and metoclopramide, enhanced field stimulation-induced contractions of guinea-pig stomach strips and gastric emptying in the guinea-pig after peripheral, intracerebroventricular and intrahypothalamic injection. in the isolated vagal nerve preparation from the rabbit, both compounds were shown to be 5-hydroxytryptamine m-receptor antagonists. dazopride and metoclopramide were equipotent in antagonising cisplatin-induced emesis in the ferret, wherea ... | 1987 | 3114664 |
| the effects of hypertonicity on tension and intracellular calcium concentration in ferret ventricular muscle. | 1. tension and intracellular calcium concentration ([ca2+]i) were measured in isolated ferret papillary muscles exposed to hypertonic solutions. [ca2+]i was measured with aequorin which was microinjected into surface cells of the preparation. correction was made for the effects of ionic strength on aequorin sensitivity to ca2+. 2. application of 100 mm-mannitol increased both developed tension and the intracellular ca2+ signals on contraction (the ca2+ transients). 300 mm-mannitol increased the ... | 1987 | 3116206 |
| the effects of calcium on potassium transport in ferret red cells. | 1. the effects of changes in the concentration of intracellular calcium on potassium transport were investigated in ferret red cells. bumetanide was used to divide potassium transport into three components: total, bumetanide sensitive and bumetanide resistant. the bumetanide-sensitive component is equivalent to sodium-potassium-chloride co-transport. 2. internal calcium concentration was controlled with the ionophore a23187 which was present throughout the experiments. 3. changes in internal ion ... | 1987 | 3119819 |
| the contribution of intracellular acidosis to the decline of developed pressure in ferret hearts exposed to cyanide. | 1. the concentrations of phosphorus-containing metabolites were measured using 31p nuclear magnetic resonance (n.m.r.) in langendorff-perfused ferret hearts. the hearts were stimulated at a constant rate and developed pressure was measured. 2. the inhibition of oxidative phosphorylation with cyanide (2 mm) decreased developed pressure. this was accompanied by an intracellular acidosis, a fall in the concentration of phosphocreatine ([pcr]) and a rise in that of inorganic phosphate ([pi]). 3. the ... | 1987 | 3127579 |
| ca2+ transients in perfused hearts revealed by gated 19f nmr spectroscopy. | gated acquisition of 19f nuclear magnetic resonance spectra from perfused ferret hearts loaded with the fluorinated ca2+ indicator 5,5'-f2-bapta allows direct quantitation of the cyclical changes in the intracellular free ca2+ concentration ([ca2+]i) that underlie contraction in intact hearts. [ca2+]i increased from approximately 200 nm in diastole to approximately 1 microm or higher in early systole. although the 19f spectra that report [ca2+]i changed dramatically and reproducibly during the c ... | 1988 | 3136952 |
| the effects of magnesium on potassium transport in ferret red cells. | 1. the magnesium dependence of net and isotopic (using 86rb as tracer) potassium transport was measured in fed ferret red cells. bumetanide (0.1 mm) was used to dissect total flux into two components: bumetanide sensitive and bumetanide resistant. 2. increasing the external magnesium concentration from zero (added) to 2 mm stimulated bumetanide-sensitive uptake by 16% but inhibited the bumetanide-resistant component by about 20%. 3. ionophore a23187 was used to control internal magnesium concent ... | 1988 | 3137332 |
| eicosanoid production in isolated perfused lungs stimulated by calcium ionophore a23187. | the patterns of lung eicosanoid production were investigated in five different species by stimulating isolated lungs with calcium ionophore a23187 (10(-5) m). the species studied were the rat, ferret, hamster, guinea pig, and rabbit. the eicosanoids measured included the cyclooxygenase metabolites 6-keto-pgf1 alpha, txb2, and pge2 and the lipoxygenase metabolites ltc4, ltd4, and ltb4. since these metabolites are either retained in the lungs or released into the perfusate, eicosanoids were measur ... | 1988 | 3144209 |
| mucosal inhibition of cholinergic contractions in ferret trachea can be transferred between organ baths. | the influence of the mucosa on the contractile responses to cholinergic nerve stimulation in an in vitro nerve muscle preparation of ferret trachea was studied. repeated contractions were induced by alternating direct vagal nerve stimulation (dns) and electrical field stimulation (efs). with intact mucosa there was a marked successive decrease of the contractile responses. during 60 minutes the responses decreased to 46 +/- 8% of baseline (mean +/- sem, n = 6), compared to 86 +/- 2% in preparati ... | 1988 | 3147197 |
| calcium concentration in the myoplasm of skinned ferret ventricular muscle following changes in muscle length. | 1. ferret ventricular muscles were skinned by prolonged application of triton x-100. aequorin was allowed to diffuse into the myoplasmic space and the resulting light emission was used to monitor the myoplasmic [ca2+]. the muscle was then activated with a lightly buffered ca2+ solution and the changes in myoplasmic [ca2+] and tension in response to length changes were investigated. 2. a sudden reduction in muscle length led to a rapid increase in myoplasmic [ca2+] to a new level which was mainta ... | 1988 | 3151492 |
| centrarchid fish as paratenic hosts of the giant kidney worm, dioctophyma renale (goeze, 1782), in ontario, canada. | infective larvae of dioctophyma renale were found in the hypaxial musculature of pumpkinseed (lepomis gibbosus l.) from three lakes in algonquin provincial park, ontario, canada. this represents the first report of d. renale in centrarchid fish. in the three lakes surveyed prevalence and mean intensity ranged from 5 to 23% and one to two larvae respectively. larvae elicited a mild granulomatous reaction in pumpkinseed. two ferrets were each given five larvae from pumpkinseed. adult d. renale wer ... | 1985 | 3157009 |
| the electrocardiogram of normal ferrets and ferrets with right ventricular hypertrophy. | sixty-eight electrocardiograms were recorded on ferrets (mustela putorius furo). these represent 29 normal weanling males, 19 normal adult males and 20 adult males with right ventricular hypertrophy (rvh). analyses of rate, rhythm, axis and total voltage were used to define the normal electrocardiogram (ecg) and to identify changes seen in rvh. the normal ferret has a heart rate of about 300 beats per minute and a mean electrical axis of + 86 degrees +/- 6.6 (sd). a 56% increase in right ventric ... | 1985 | 3160888 |
| gastric colonization by campylobacter pylori subsp. mustelae in ferrets. | campylobacter pylori subsp. mustelae was cultured from both normal and inflamed gastric mucosa of ferrets. examination of neonatal, juvenile, and adult ferrets established that the gastric mucosa in the majority of preweanling (age, less than 6 weeks) ferrets sampled were not colonized with c. pylori subsp. mustelae, whereas the gastric mucosa of 100% of adult ferrets were colonized with this gastric organism. c. pylori subsp. mustelae was isolated from the gastric mucosa on a sequential basis f ... | 1988 | 3169994 |
| hearing in the ferret (mustela putorius): effects of primary auditory cortical lesions on thresholds for pure tone detection. | 1. pure tone thresholds were determined for five adult male ferrets before and after bilateral ablation of primary auditory cortex. complete audiograms ranging from 0.016 to 48 khz were obtained for two animals. the remaining three animals were tested at five frequencies selected to assess hearing throughout the audible range (0.125, 0.5, 2.0, 8.0, and 32.0 khz). 2. shortly after surgery one animal had elevated thresholds across the entire frequency range with the most pronounced hearing loss ab ... | 1988 | 3171665 |
| comparative effects of halothane, enflurane, and isoflurane at equipotent anesthetic concentrations on isolated ventricular myocardium of the ferret. i. contractility. | the effects of halothane, enflurane, and isoflurane on myocardial contractility were compared in papillary muscles of the right ventricle of adult male ferrets at 30 degrees c. isotonic and isometric variables of contractility were measured before, during, and after exposure to incremental concentrations of halothane (n = 9 muscles), enflurane (n = 9 muscles), and isoflurane (n = 9 muscles), in steps of 0.25 mac up to 1.5 mac of halothane and of enflurane, and up to 2.0 mac of isoflurane. each o ... | 1988 | 3177907 |
| comparative effects of halothane, enflurane, and isoflurane at equipotent anesthetic concentrations on isolated ventricular myocardium of the ferret. ii. relaxation. | the effects of halothane, enflurane, and isoflurane on myocardial relaxation were compared in papillary muscles of the right ventricle of adult male ferrets at 30 degrees c. the sensitivity of cardiac relaxation to the loading conditions was determined by examining the time course of relaxation before, during, and after exposure to incremental concentrations of halothane (n = 9 muscles), enflurane (n = 9 muscles), and isoflurane (n = 9 muscles) in steps of 0.25 mac up to 1.5 mac of halothane and ... | 1988 | 3177908 |
| the characterization and pathological significance of gastric campylobacter-like organisms in the ferret: a model for chronic gastritis? | gastric campylobacter-like organisms (clo) were isolated from gastric tissues removed at sacrifice from 17 mature ferrets; all animals were colonized, but no macroscopic mucosal lesions or histological features of chronic gastritis were seen. the isolates resembled campylobacter pylori in many cultural and biochemical characteristics, and produced substantial urease activity, but there were sufficient differences from c. pylori to suggest that ferret gastric clo represents a separate species. co ... | 1988 | 3181311 |
| antibody titers in domestic ferret jills and their kits to canine distemper virus vaccine. | antibody titers were measured in domestic or european ferret (mustela putorius furo) jills vaccinated with modified-live canine distemper virus (cdv) vaccine and in their kits. the half-life of maternal antibody to cdv in ferrets was 9.43 days. ferret kits should be vaccinated against cdv at 6, 10, and 14 weeks of age. | 1988 | 3182383 |
| stimulation of submucosal glands by nicotine applied locally to the airway mucosa. | chronic bronchitis is characterized by hypersecretion of mucus and is caused by cigarette smoking. we investigated the effect of nicotine on mucus secretion from tracheal submucosal glands, applying nicotine to the airway mucosa in vitro. we anesthetized 50 ferrets with pentobarbital (66 mg/kg), excised their tracheae and mounted tracheal segments in ussing chambers. we added 50 microci na(2)35so4 (35s) to the submucosal side and determined nondialyzable 35s in medium collected from the luminal ... | 1988 | 3184773 |
| effect of systemic nicotine on mucus secretion from tracheal submucosal glands and on cardiovascular, pulmonary, and hematologic variables. | to investigate effects of systemic nicotine on mucus secretion from tracheal submucosal glands we anesthetized 13 ferrets (5 male, 8 female; average weight 1138 +/- 469 g, mean +/- sd) with pentobarbital (initial dose, 62 +/- 26, total dose, 90 +/- 26 mg/kg), cannulated the jugular vein for i.v. application of infusions and drugs and cannulated the femoral artery for determination of blood pressure, heart rate, blood cells, and blood gases. we opened the thorax, cannulated the trachea 1 cm above ... | 1988 | 3184774 |
| serum thyroxine and triiodothyronine radioimmunoassay values in the normal ferret. | the european ferret, mustela putorius furo, has become increasingly popular as an animal model in biomedical research. however, certain important normal clinical data have not been established for the ferret. in this study, serum thyroxine (t4) and 3,3',5-triiodothyronine (t3) values were obtained from ferrets by the use of commercial radioimmunoassays. sera from 44 animals, 31 males (27 intact and 4 castrated) and 13 females (10 intact and 3 spayed) were assayed. serum t4 values ranged from 1.0 ... | 1988 | 3184856 |
| estimation of the upper limit of the free magnesium concentration measured with mg-sensitive microelectrodes in ferret ventricular muscle: (1) use of the nicolsky-eisenman equation and (2) in calibrating solutions of the appropriate concentration. | determination of intracellular free magnesium [( mg]i) with ion-selective mg microelectrodes filled with the neutral carrier eth 1117 is critically dependent on the values taken for k and na in the calibrating solutions, for intracellularly the mg microelectrodes also respond to these ions. this study was designed to test the influence of k and na on the measured [mg]i in ferret ventricular muscle. to estimate the effect of these ions, two methods were used: calculation based on the nicolsky-eis ... | 1988 | 3185015 |
| coma in a ferret after ingestion of cannabis. | 1988 | 3188373 | |
| more on ferrets as pets. | 1988 | 3192469 | |
| controlled cortical impact: a new experimental brain injury model. | a new experimental model of mechanical brain injury was produced in the laboratory ferret (mustela putorius furo) using a stroke-constrained pneumatic impactor. cortical impacts were made on vertex to the intact dura mater overlying the cerebral cortex with contact velocities ranging from 2.0 to 4.0 m/sec and with deformations of 2.0 to 5.0 mm. the dwell time of the impact and the stability of the skull during impact were verified with high speed (1000 to 3000 frames/sec) cineradiography. system ... | 1988 | 3193461 |
| a tethered-restraint system for blood collection from ferrets. | 1988 | 3193763 | |
| ca2+ transient, mg2+, and ph measurements in the cardiac cycle by 19f nmr. | 19f nmr indicators have been used to measure the free cytosolic cation concentrations ([mn+]i, where m is the atomic symbol and n is the value of the charge) of ca2+, h+, and mg2+ in perfused ferret hearts. the [ca2+]i transient, cytosolic ph (phi), and [mg2+]i have also been followed at 16 phases in the cardiac cycle in hearts paced at 1.25 hz at 30 degrees c. the initial [ca2+]i rose rapidly after a 50-ms delay, was maximal at greater than 1.5 microm after 150 ms, and declined thereafter to th ... | 1988 | 3194404 |
| modulation by the thyroid state of intracellular calcium and contractility in ferret ventricular muscle. | the purpose of this study was to determine whether the cardiac contractile abnormalities induced by hyperthyroidism or hypothyroidism are caused by changes in intracellular ca2+ handling or by alterations in the distribution of isoenzymes of ventricular myosin. right ventricular papillary muscles obtained from euthyroid ferrets and ferrets treated with l-thyroxine (hyperthyroid) or methimazole (hypothyroid) were loaded with the calcium indicator aequorin for recording intracellular ca2+ levels d ... | 1988 | 3197273 |
| an anomaly in the auditory brain stem projections of hypopigmented ferrets. | the number of cochlear nucleus (cn) neurones projecting to the ipsi- and contralateral inferior colliculus (ic) was studied in darkly pigmented and hypopigmented ferrets by the retrograde transport of wheat germ agglutinin-horseradish peroxidase. the contralateral projection in all divisions of the cn of both albino and 'red eyed' ferrets was normal. however, the ipsilateral projection from the anteroventral cn was significantly smaller in albino than in pigmented ferrets. the volume of each div ... | 1988 | 3198516 |
| development, organization, and function of tight junctional complexes in the tracheal epithelium of infant ferrets. | the surface epithelium of newborn ferret airways matures rapidly in the first month of life. prominent developmental features include a transition from predominantly non-ciliated to ciliated cells, quantitative and qualitative changes in secretion of macromolecules, and a transition from secretory to absorptive patterns of ion transport. freeze-fracture replicas of ferret tracheal epithelium from 0 to 28 days of age exhibited progressive developmental patterns in tight junctional structure from ... | 1988 | 3202419 |
| dissociation of changes in apparent myofibrillar ca2+ sensitivity and twitch relaxation induced by adrenergic and cholinergic stimulation in isolated ferret cardiac muscle. | in isolated, aequorin-injected ferret cardiac muscle we measured the apparent myofilament ca2+ sensitivity and its relationship to twitch relaxation time in the presence of autonomic perturbations. the ca2+-tension relation was determined from the peak aequorin luminescence and peak twitch tension measured in muscles across a broad range of bathing [ca2+] in the presence and absence of acetylcholine (ach) (1 microm) or isoproterenol (isn) (1 microm), or both drugs. ach shifted the relationship o ... | 1988 | 3204364 |
| erythrocyte adducin. comparison of the alpha- and beta-subunits and multiple-site phosphorylation by protein kinase c and camp-dependent protein kinase. | two major substrates for human erythrocyte protein kinase c (pk-c) of mr 120,000 and 110,000, previously named pkc-1 and pkc-2 [palfrey, h. c. & waseem, a. (1985) j. biol. chem. 260, 16021-16029] have been found to be identical to cam-bp 103/97 or 'adducin', recently described by k. gardner and v. bennett [(1986) j. biol. chem. 261, 1339-1348; (1987) nature (lond.) 328, 359-362]. these proteins have been purified from the membrane skeleton by high-salt extraction, ion-exchange and gel filtration ... | 1988 | 3208770 |
| the anesthetized ferret, an in vivo model for evaluating inotropic activity: effects of milrinone and anagrelide. | the anesthetized ferret model is introduced as an in vivo acute model for evaluating inotropic effects of new cardiovascular compounds. the effects of anagrelide and milrinone were compared to vehicle. validation was accomplished using intravenous isoproterenol, which elicited a dose-dependent inotropic response. this suggests that the anesthetized ferret model is both reproducible and dependable. additionally, in vivo inotropic activity can be assessed on small amounts of compound in a relative ... | 1988 | 3210682 |
| fine structural changes in the developing gastric gland cells in the ferret during the postnatal period. | the development of the gastric gland cells in the ferret was studied with particular reference to maturation during the postnatal period. in the newborn, the glands consist of immature parietal cells with numerous mitochondria, and shallow rudimentary intracellular canaliculus with numerous microvilli, and undifferentiated cells. at one week old, mucous neck cells are present containing scattered mucin granules and the parietal cells contain tubulovesicular components. at two weeks old chief cel ... | 1988 | 3212277 |
| transmission of measles virus encephalitis to ferrets by intracardiac inoculation of a cell-associated sspe virus strain. | ferret fibroblasts infected with a cell-associated strain of subacute sclerosing panencephalitis virus were inoculated into the hearts of ferrets in order to study whether the virus can spread from the blood to the brain in this animal model. five of 21 inoculated ferrets developed encephalitis 5-7 days later and were sacrificed. sick animals showed inflammatory lesions in the brain, both perivascular cuffings and infiltration of inflammatory cells in the choroid plexus and meninges. virus was i ... | 1988 | 3214585 |
| the effects of repeated exposure to anoxia on intracellular calcium, glycogen and lactate in isolated ferret heart muscle. | isolated cardiac tissue from the ferret was repeatedly exposed to anoxia while perfused with glucose-containing tyrode solution. in one series of experiments, papillary muscles were injected with aequorin to measure intracellular ca2+. on the first exposure to anoxia, the ca2+ transients often increased, but on subsequent exposures this increase disappeared and eventually the ca2+ transients declined on exposure to anoxia. this decline in the ca2+ transients could be converted back to an increas ... | 1988 | 3217230 |
| size distribution of ferret luteal cells during pregnancy. | steroidogenic cells in the corpus luteum of the ferret (mustela putorius) during early (days 6 and 13) to midpregnancy (day 24) were characterized using electron microscopy, immunocytochemical localization of neurophysin, and smears of dispersed cells obtained by dissociating luteal cells with collagenase. the latter were stained for 3 beta-hydroxysteroid dehydrogenase (3 beta-hsd) activity, and the diameters of the cells were determined with an ocular micrometer. very small cells (less than 12 ... | 1988 | 3219387 |
| the effects of peptide histidine isoleucine and neuropeptide y on mucus volume output from the ferret trachea. | 1. the effects of peptide histidine isoleucine (phi) and neuropeptide y (npy) were examined on the mucus volume output produced by methacholine and phenylephrine in the ferret whole trachea in vitro. 2. sustained application of methacholine (5 microm) or phenylephrine (20 microm) produced a maintained volume output of mucus from the trachea. both these agonists also increased the output of lysozyme (a marker for serous cell secretion). 3. phi inhibited the maintained mucus volume output produced ... | 1988 | 3219475 |
| effects of rapid application of caffeine on intracellular calcium concentration in ferret papillary muscles. | in this paper we investigate the effects of caffeine (5-20 mm) on ferret papillary muscle. the intracellular ca2+ concentration ( [ca2+]i) was measured from the light emitted by the photoprotein aequorin, which had previously been microinjected into superficial cells. isometric tension was measured simultaneously. the rapid application of caffeine produced a transient increase of [ca2+]i, which decayed spontaneously within 2-3 s and was accompanied by a transient contracture. the removal of extr ... | 1988 | 3225553 |
| isoelectric focusing of ureases from campylobacter pylori and related organisms. | agarose gel isoelectric focusing was used to determine the isoelectric points of ureases from strains of gastric campylobacterlike organisms isolated from ferrets (pi 5.4), baboons (pi 5.7), and pigs (pi 5.9) and from isolates of campylobacter pylori in humans (pi 5.9). this technique may help differentiate these closely related bacteria. | 1988 | 3230144 |
| whole body lymphangioscintigraphy in ferrets chronically infected with brugia malayi. | whole body lymphangioscintigraphy was performed after intradermal injection of 99mtechnetium human serum albumin or antimony colloid in the distal hindlimbs and forelimbs of ferrets chronically infected with brugia malayi. the findings were compared with control ferrets and those with surgical interruption of the iliac lymphatics. while only one infected ferret manifested chronic hindlimb lymphedema, all exhibited delayed transport of radioisotope from the hindpaw with obstruction in the groin, ... | 1988 | 3236904 |
| role of upper respiratory tract infection in the deaths occurring in neonatal ferrets infected with influenza virus. | passive immunization of ferret neonates by colostrally-derived anti-influenza virus igg did not entirely prevent infection when mothers were immunized with 1 or 2 doses of formalin inactivated vaccine with adjuvant (alhydrogel). influenza virus replication was almost completely prevented in the lower respiratory tract but only slightly reduced in the upper respiratory tract leading to deaths in about 50% of the neonates. such neonates showed at most only minor lesions in the lower respiratory tr ... | 1988 | 3237053 |
| reflex responses of vagal efferent fibres influenced by gastrointestinal mechanoreceptors to electrical afferent stimulation in the anaesthetized ferret. | activity was recorded from 188 vagal efferent fibres, 90% of which showed responses to distension of the stomach and duodenum. of thirty fibres tested with single-shock vagal stimulation, reflex action potentials were evoked in fifteen, ranging in latency from 39 to 318 ms. responses at short latency showed little latency-jitter and high response-probability, and those at long latency showed opposite characteristics. this suggests that two pathways are present in the central organization of vaga ... | 1988 | 3237977 |
| desheathing the nodose ganglion is not a reliable method of de-efferentation in the ferret. | the present study reports the results of physiological and anatomical experiments in which the purpose was to determine whether desheathing the nodose ganglion is a reliable method of vagal de-efferentation in the ferret. in physiological studies, the effects of electrically stimulating the treated and untreated vagal nerves on cardiovascular and intestinal responses were examined and compared with previously obtained data after left supranodose vagotomy. the anatomical studies illustrated the e ... | 1988 | 3242504 |
| interaction of contact velocity and cord compression in determining the severity of spinal cord injury. | rate, depth, and duration of compression are the principal determinants of experimental spinal cord injury (sci) severity. since existing models do not allow independent control of these variables, the interaction of these factors has not been fully elucidated. the purpose of this study was to define the interactive relation of velocity (v) and compression (c) in sci using a constrained stroke pneumatic impactor that allowed independent control of these variables. computer simulation of previous ... | 1988 | 3246693 |
| electrocardiographic values from clinically normal, anesthetized ferrets (mustela putorius furo). | electrocardiograms were recorded from 25 clinically normal male ferrets anesthetized with ketamine and xylazine and from 7 ferrets anesthetized with ketamine alone. ferrets anesthetized with ketamine alone had excessive salivation, open eyes, muscle tremors, muscle twitching, paddling motions, attempts to stand, and an unstable ecg baseline. because ketamine/xylazine combination resulted in induction and good muscle relaxation, the ecg had little interference resulting from muscular movement. | 1988 | 3247910 |
| the negative inotropic effect of acetylcholine on ferret ventricular myocardium. | 1. the effects of acetylcholine (ach) on developed tension and intracellular ca2+ concentration (as measured with aequorin) were studied in ferret papillary muscles, and on twitch shortening, the action potential and membrane currents in ferret ventricular myocytes. 2. addition of ach to ferret papillary muscles resulted in decreases in developed tension and the intracellular ca2+ transient, both of which then partially recovered in the continued presence of ach ('fade' of the response). on wash ... | 1988 | 3253444 |
| the effects of changes in muscle length during diastole on the calcium transient in ferret ventricular muscle. | 1. ferret papillary muscles were isolated and injected with aequorin to measure intracellular ca2+ concentration [( ca2+]i). developed tension and [ca2+]i were measured in response to length changes. 2. a maintained reduction in muscle length produced an immediate decrease in developed tension followed by slow decline over 10-20 min. this slow decline in tension was accompanied by a slow decline in the amplitude of the systolic [ca2+]i rise (the ca2+ transient). the immediate decrease in tension ... | 1988 | 3254417 |
| antigenic heterogeneity within influenza a (h3n2) virus strains. | on the basis of their antigenic properties, influenza virus strains are classified into types and subtypes, which are further subdivided into variants that differ to various degrees in haemagglutination-inhibition assays. evidence is presented that during infection with an influenza a(h3n2) virus the respiratory tract of a human patient often harbours more than one antigenic virus variant. these variants are frequently propagated by embryonated fowl eggs and monkey cells with different efficienc ... | 1988 | 3260141 |
| purification and initial characterization of a ferret pneumocystis carinii surface antigen. | the purification and initial characterization of a ferret pneumocystis carinii surface glycoprotein is described. previous studies have demonstrated that passive administration of monoclonal antibody recognizing this glycoprotein reduces the severity of p. carinii pneumonitis in animal models of infection. this acidic glycoprotein (approximate isoelectric point, 5.0-5.7) contains both mannose (and/or glucose) and n-acetyl-glucosamine residues. the cross-reactive surface antigen on p. carinii of ... | 1988 | 3262695 |
| nucleolar eccentricity in trigeminal ganglion neurons. | the aim of this study was to determine if measuring trigeminal ganglion neuron profiles containing nucleoli in histological sections gave a reasonable estimation of cell size. serial sections of ferret trigeminal ganglia were prepared, and neuron profiles traced with the aid of a camera lucida. the cross sectional area of the profiles was measured. profiles containing nucleoli formed the upper part of the size spectrum and were significantly larger than the profiles that did not contain nucleoli ... | 1988 | 3264279 |
| neutral endopeptidase and angiotensin converting enzyme inhibitors potentiate kinin-induced contraction of ferret trachea. | neutral endopeptidase (nep) (enkephalinase, ec 3.4.24.11) and angiotensin converting enzyme (ace) are two peptidases that can cleave the c-terminal dipeptide bradykinin(8-9) from bradykinin. to determine whether these peptidases play roles in modulating kinin-induced contractions in the airways, we studied the effects of captopril, an ace inhibitor, and of leucine-thiorphan and phosphoramidon, two nep inhibitors, on the contractile responses to bradykinin and lysyl-bradykinin in isolated segment ... | 1988 | 3279179 |
| lessons for human influenza from pathogenicity studies with ferrets. | in research on influenza, little attention has been given to factors that determine the patterns of infection in human adults or infants and the severity of disease. ferret influenza has been used to elucidate the following facets of pathogenicity that bear on these questions about human disease: the differential infectivity of virus strains for the upper respiratory tract (urt); the reasons for less severe infection of the lower respiratory tract (lrt) than of the urt; why pneumonia is rare; an ... | 1988 | 3281223 |
| campylobacter-like omega intracellular antigen in proliferative colitis of ferrets. | proliferative colitis in the ferret consistently displays, along with marked proliferation of mucosal cells, intracytoplasmic campylobacter-like organisms within the apical portion of the epithelial cells. fluorescent antibody to "omega" campylobacter antigen present in porcine intestinal adenomatosis and hamster proliferative ileitis was demonstrated at the site of bacterial colonization within hyperplastic epithelial cells of six colons from ferrets affected with proliferative colitis. | 1988 | 3285095 |
| immunocytochemical localization of hypothalamic luteinizing hormone-releasing hormone in male ferrets. | lhrh-containing neurons within the hypothalamus were immunocytochemically identified in adult male ferrets that were either gonadally intact, castrated, or castrated and treated with testosterone. the distribution of lhrh-immunopositive neuron cell bodies was similar in the three treatment groups. the majority of these cells was located mediobasally in the retrochiasmatic area, including some within the ventrolateral aspects of the arcuate nucleus. these soma were associated with a dense basal l ... | 1988 | 3285966 |
| characterization of several monoclonal antibodies generated against ferret tracheal epithelial cells. | monoclonal antibodies have been generated to ferret tracheal epithelial (fte) cells. four of the antibodies exhibiting positive reactivity in a fluorescence-activated cell sorter were further characterized. in tracheal sections, three of the antibodies reacted with submucous gland cells and material intermeshed in the cilia while the fourth antibody failed to react with epithelial cells. the three antibodies which reacted in tracheal sections also reacted with void volume fractions following sep ... | 1987 | 3298002 |
| sex difference in the effect of mating on the pulsatile secretion of luteinizing hormone in a reflex ovulator, the ferret. | sex differences in the pulsatile secretion of lh were examined in male and female ferrets after mating. female ferrets which were either gonadally intact and in estrus or gonadectomized and maintained on a pulsed regimen of daily estradiol (e2) injections exhibited a prolonged rise in plasma lh, characterized by an elevation in mean lh levels and an increase in the number of lh pulses after receiving an intromission from a stud male. by contrast, no such increase in lh secretion occurred in male ... | 1987 | 3308435 |
| biology and medicine of the ferret. | there is still much more to be learned about ferret behavior, nutrition, and physiologic responses associated with aging, disease, and environmental stimuli. the many similarities in the clinical disorders of ferrets and other small companion animals should emphasize the importance of using the same diagnostic methods developed for common companion animals in examinations of ferrets. there is still very little known of the efficacy of a wide spectrum of drugs in ferrets, and judicious use of pha ... | 1987 | 3310372 |
| evidence that 5-hydroxytryptamine3 receptors mediate cytotoxic drug and radiation-evoked emesis. | the involvement of 5-hydroxytryptamine (5-ht) 5-ht3 receptors in the mechanisms of severe emesis evoked by cytotoxic drugs or by total body irradiation have been studied in ferrets. anti-emetic compounds tested were domperidone (a dopamine antagonist), metoclopramide (a gastric motility stimulant and dopamine antagonist at conventional doses, a 5-ht3 receptor antagonist at higher doses) and brl 24924 (a potent gastric motility stimulant and a 5-ht3 receptor antagonist). domperidone or metoclopra ... | 1987 | 3311109 |
| effects of induced thrombocytopenia on viral invasion of the central nervous system in canine distemper virus infection. | groups of canine distemper virus (cdv) susceptible ferrets were treated daily with 2.0 ml of normal goat serum (ngs) or goat anti-ferret platelet serum from 2 days before to 11 days after infection. each group was subdivided into 2 and one subgroup of each was subsequently injected intraperitoneally with virulent r252-cdv. ferrets were killed on days 2, 4, 6, 9 and 11 after infection and tissues from the central nervous system (cns) were examined for histopathological lesions typical for cdv and ... | 1987 | 3312311 |
| characterization of lh-rh immunoreactivity in mammalian pituitary neural lobe by hplc. | high performance liquid chromatography was used to characterize luteinizing hormone-releasing hormone (lh-rh) immunoreactivity that was previously identified immunocytochemically in the pituitary neural lobes of bats, ferrets and humans. extracts of bat posterior lobe and hypothalamus, ferret posterior lobe and hypothalamus and human neurohypophysis were partially purified with c-18 bond-elut cartridges. samples were chromatographed using a c-18 reverse phase hplc column, and lh-rh-immunoreactiv ... | 1987 | 3315122 |
| sequential infection or immunization of ferrets with a series of influenza a (h3n2) strains (report to the medical research council's sub-committee on influenza vaccines (cdvip/iv)). | previous studies of boys at christ's hospital school have indicated that annual immunization with influenza virus vaccines did not significantly reduce the total incidence of influenza infection compared to unimmunized subjects. in view of the implications of this result, a similar study was conducted in ferrets to clarify these findings. groups of ferrets were immunized or infected with a series of influenza a (h3n2) viruses over an 18-month period, and the immunity to subsequent live virus cha ... | 1987 | 3315713 |
| use of single radial haemolysis for assessing antibody response to influenza virus vaccines in animals. | the value of the single radial haemolysis (srh) test as a possible replacement for the haemagglutination-inhibition (hai) test for the estimation of antibodies against influenza was assessed in three animal models. the serum antibody response was measured by both assay systems; correlation of the two tests was assessed using regression analysis. the study showed that when the response to a single immunisation was determined, the ferret model gave satisfactory correlation of srh and hai, whilst i ... | 1987 | 3323861 |
| measles virus matrix protein gene expression in a subacute sclerosing panencephalitis patient brain and virus isolate demonstrated by cdna hybridization and immunocytochemistry. | subacute sclerosing panencephalitis (sspe) is a rare, fatal disease of children caused by a persistent measles virus infection of the central nervous system. a defect in synthesis of measles virus matrix (m) protein may be a factor in virus persistence in the brain. this study details attempts to detect expression of m protein in the brain of an sspe patient, in the cell-associated virus isolated from this brain, and in brains of ferrets inoculated with the isolate. in situ hybridization with a ... | 1987 | 3324622 |
| variation of the ferret skull (mustela putorius furo l.) in relation to stereotaxic landmarks. | the ferret skull was investigated to identify reliable extracranial landmarks for stereotaxy. the skulls of 56 ferrets of both sexes were measured in a stereotaxic apparatus. neither body weight nor an index of skull length proved to be reliable predictors of intracranial location. sutures fused too early in life for lambda and bregma to be useful as landmarks in adult ferrets. the position of extracranial features was used to predict the position of intracranial features. for rostral intracrani ... | 1987 | 3328744 |
| mono-, di- and trimethylamine in human gastric fluid: potential substrates for nitrosodimethylamine formation. | nitrosodimethylamine (ndma) is a potent carcinogen in a wide variety of animal species. in experimental animals, dimethylamine and nitrite, precursors of ndma, are found in gastric fluid where the acidic conditions are suitable for formation of nitrosamines. in this study we measured the concentrations of mono-, di- and trimethylamine (mma, dma and tma) in gastric fluid from humans, rats, dogs and ferrets, as well as in saliva, blood and urine from humans. human gastric fluid contained 3.7 +/- 0 ... | 1988 | 3335043 |
| maximal twitch tension in intact length-clamped ferret papillary muscles evoked by modified postextrasystolic potentiation. | a modified test of postextrasystolic potentiation achieved with a brief episode of rapid pacing followed by a 6-second pause (rpp maneuver) was used to evoke maximal force in isolated intact ferret right ventricular papillary muscles. maximal rpp tensions were examined under length-clamped conditions and compared with the steady-state forces obtained when further increases in [ca2+]o, did not further increase force and to the tensions recorded at the point of saturation of force when similarly l ... | 1988 | 3335058 |
| four viral genes independently contribute to attenuation of live influenza a/ann arbor/6/60 (h2n2) cold-adapted reassortant virus vaccines. | clinical studies previously demonstrated that live influenza a virus vaccines derived by genetic reassortment from the mating of influenza a/ann arbor/6/60 (h2n2) cold-adapted (ca) donor virus with epidemic wild-type influenza a viruses are reproducibly safe, infectious, immunogenic, and efficacious in the prevention of illness caused by challenge with virulent wild-type virus. these influenza a reassortant virus vaccines also express the ca and temperature sensitivity (ts) phenotypes in vitro, ... | 1988 | 3336068 |
| effect of birth on plasma testosterone, brain aromatase activity, and hypothalamic estradiol in male and female ferrets. | the present studies examined the patterns of circulating testosterone (t) within 0-24 h after birth in male and female ferrets along with concomitant changes in neural aromatase activity and hypothalamic concentrations of estradiol (e2). plasma and brain samples were obtained 0 and 2 h (cesarean delivery) or 0, 2, 12, and 24 h (natural delivery) after birth. plasma t levels were significantly higher in male neonates 2 h after birth than at 0 h in both cesarean-delivered (9.48 +/- 1.25 vs. 3.37 + ... | 1988 | 3338412 |
| changes in endometrial vascular permeability during the periimplantation period in the ferret (mustela putorius). | a highly localized increase in permeability of uterine blood vessels in the immediate vicinity of implanting blastocysts was first detected on the morning of the 12th day of pregnancy (290 h post coitum). the amount of extravasated dye which accumulated at implantation sites continued to increase through the evening of day 13 (321 h p.c.). blastocyst expansion, as indicated by small uterine swellings, preceded a detectable change in vascular permeability by about 10 h, suggesting that the timing ... | 1988 | 3339587 |
| a new conditioning paradigm: conditioned limb movements in locomoting decerebrate ferrets. | these experiments address the hypothesis that the trajectory of a forelimb in decerebrate ambulating ferrets can be conditioned to avoid an obstacle encountered during the locomotor cycle. the perturbation was produced by interjecting a bar into the trajectory of the forelimb during swing phase. over 5-15 steps the flexion of the elbow progressively increased until the forelimb was elevated over the bar. avoiding the bar often required that the maximum height of the paw during swing phase was do ... | 1988 | 3340324 |
| peptidergic neurohormonal systems in the basal hypothalamus of the ferret and the mink: immunocytochemical study of variations during the annual reproductive cycle. | the hypothalamic systems secreting corticotropin-releasing hormone (crf), somatostatin, oxytocin, vasopressin and luteinizing hormone-releasing hormone (lhrh) were characterized using immunochemistry, and variations were studied in relation to the recrudescence of testicular activity in the ferret and the mink, two species with opposite photoregulation of their annual reproductive cycles. under the present conditions of study, the immunoreactivity of the crf, somatostatin, and oxytocin systems s ... | 1988 | 3342434 |
| contractile dysfunction and atp depletion after transient calcium overload in perfused ferret hearts. | although a number of lines of evidence hint that an elevation of intracellular calcium leads to myocardial injury, the cellular consequences of transient ca overload remain unclear. to determine the contractile, histologic, and metabolic sequelae of transient ca overload, we measured developed pressure (dp) in isovolumetric langendorff-perfused ferret hearts at 37 degrees c before and 20 min after three 5 min periods of perfusion with a 10 mm [ca]o, 1 mm [mg]o solution (high-ca group, n = 8) wit ... | 1988 | 3342494 |
| differential release of vasopressin and oxytocin in response to abdominal vagal afferent stimulation or apomorphine in the ferret. | the aim of this study was to investigate whether direct afferent stimulation of the abdominal vagus could promote release of the neurohypophyseal hormones. the nucleus of the solitary tract is the major recipient of vagal afferent information, and this region of the brainstem may also be activated by stimulation of the area postrema. for this reason apomorphine, a d2 dopaminergic agonist which acts on the area postrema, and can evoke vasopressin secretion in man, was also investigated for its ef ... | 1988 | 3345426 |
| genesis of gaba-immunoreactive neurons in the ferret visual cortex. | the pattern of neurogenesis of gaba-immunoreactive neurons in the ferret primary visual cortex was determined using immunohistochemical and 3h-thymidine autoradiographic techniques. neurons in the visual cortex of the ferret undergo their final cell division during a period extending from embryonic day 20 (e20) to postnatal day 14 (p14) and follow an inside-out pattern of neuronal production (jackson et al., 1984) similar to that observed in other mammals. earlier-generated neurons are found at ... | 1988 | 3346729 |
| fates of visual cortical neurons in the ferret after isochronic and heterochronic transplantation. | in the mammalian cerebral cortex, neurons in a given layer are generated at about the same time in development. these cells also tend to share similar sets of morphological and physiological properties and have projection patterns characteristic of that layer. this correspondence between the birthday and eventual fate of a cortical neuron suggests the possibility that the commitment of a cell to a particular laminar position and set of connections may occur very early on in cortical development. ... | 1988 | 3346731 |
| severe facial injuries to infants due to unprovoked attacks by pet ferrets. | three infants were attacked by pet ferrets and sustained severe facial injuries. two of the children had their ears bitten off and required reconstructive surgery. the attacks were unprovoked. two of the children were asleep in their cribs when they were bitten. although ferrets are increasingly popular pets, we believe that they are not suitable pets for families with small children. physicians should be aware that ferrets may unpredictably injure infants and that no effective rabies vaccine fo ... | 1988 | 3346981 |
| developmental plasticity in the visual and auditory representations in the mammalian superior colliculus. | environmental factors play an important role in certain aspects of the development of sensory systems. but the way in which the maturation of different sensory modalities is coordinated is poorly understood. we have investigated this question neurophysiologically in the mammalian superior colliculus (sc), which contains topographically aligned maps of visual and auditory space. we report here that an essentially normal auditory map, in approximate register with the visual map, is found in the sc ... | 1988 | 3347247 |
| the role of the abdominal visceral innervation and 5-hydroxytryptamine m-receptors in vomiting induced by the cytotoxic drugs cyclophosphamide and cis-platin in the ferret. | we have used the ferret as an animal model to investigate the emetic action of the cytotoxic drugs cyclophosphamide and cis-platin. using selective nerve lesions, a crucial role for the abdominal innervation in the genesis of retching and vomiting in response to these agents has been demonstrated. a combination of bilateral abdominal vagotomy and greater splanchnic nerve section can totally abolish retching and vomiting in response to intraperitoneal cis-platin or intravenous cyclophosphamide. i ... | 1988 | 3347698 |
| a mutation in the pa protein gene of cold-adapted b/ann arbor/1/66 influenza virus associated with reversion of temperature sensitivity and attenuated virulence. | reassortant sg3 inherits only the acidic polymerase (pa) protein gene from the cold-adapted b/aa/1/66 influenza virus (ca b/aa/1/66) and all remaining genes from a virulent, wild-type virus. this reassortant demonstrates attenuated virulence in ferrets and expresses a ts phenotype characteristic of the ca parent. during virulence evaluation of sg3, a virulent, non-ts revertant virus (designated sg3rfl) was isolated from the lungs of one ferret. in order to determine whether the reversion of sg3 ... | 1988 | 3354203 |
| development of ganglion cell topography in ferret retina. | the adult ferret has approximately 90,000 retinal ganglion cells, arranged in a prominent area centralis and visual streak. the role of differential cell generation, cell death, and retinal growth in the control of adult retinal ganglion cell number and distribution was evaluated by examining basic aspects of retinogenesis, including growth in retinal area, developmental changes in the number, size, and distribution of retinal ganglion cells (identification aided by retrograde transport of hrp), ... | 1988 | 3357016 |
| strongyloides stercoralis infection in the ferret. | the ferret (mustela putorius furo) was evaluated as an animal model for infection with human strains of strongyloides stercoralis. results indicate that such infections can be easily and reproducibly accomplished. | 1988 | 3357099 |
| primary auditory cortex in the ferret (mustela putorius): neural response properties and topographic organization. | microelectrode recording studies were made of the crown of the ectosylvian auditory cortex of barbiturate-anesthetized ferrets, using calibrated, sealed acoustic stimulus delivery systems. we confirmed our previous finding using free-field stimuli that this region of the ferret's cerebral cortex contains a tonotopically organized field in which neurons are briskly excited by the onset of tonal stimuli. the vast majority of neurons in this field were narrowly tuned to tone pulse frequency, with q ... | 1988 | 3359271 |
| preganglionic vagus nerve fibers also enter the greater curvature of the stomach in rats and ferrets. | the efferent gastric vagus nerve fibers appear to enter the stomach by several routes. for example, the rate of gastric acid secretion is directly affected by the nerves of the greater curvature of the stomach. specifically, acid secretion decreases abruptly after division of the gastroepiploic nerve(s). to determine whether efferent vagus nerve fibers are contained in the gastroepiploic nerve(s), horseradish peroxidase, a protein that undergoes retrograde axonal transport, was applied to these ... | 1988 | 3360257 |
| periapical innervation of the ferret canine and the local retrograde neural changes after pulpectomy. | the amputation of the dental pulp severs a population of axons that are predominantly in the a delta and c fiber size range and are principally involved in nociception. local periapical neuromas, if they are formed after pulpectomy, may be the sites of spontaneous nervous activity that may, in some circumstances, be involved in the genesis of chronic pain. the periapical tissues from the mandibular canines of four ferrets were examined 3 months after pulpectomies. silver-stained paraffin section ... | 1988 | 3364759 |
| a study of cerebellar cortical involvement in motor learning using a new avoidance conditioning paradigm involving limb movement. | these experiments were performed to examine the relationship between the simple and complex spike responses of 3-5 simultaneously recorded purkinje cells during the acquisition, performance and extinction of a conditioned forelimb movement in decerebrate, unanesthetized ferrets. the data demonstrate parallel, correlated changes in simple and complex spike responses throughout the experimental period. since the evaluated purkinje cells were examined in the cerebellar cortical region that contains ... | 1988 | 3365554 |
| a simple technique for chronic jugular catheterization in ferrets. | 1988 | 3367631 | |
| minimum alveolar concentrations (mac) of halothane, enflurane, and isoflurane in ferrets. | the minimum alveolar concentrations (mac) of isoflurane, enflurane, and halothane were determined in adult male ferrets during controlled ventilation at normothermia (37 degrees c). mean (+/- sd) mac values for isoflurane (n = 8), enflurane (n = 8), and halothane (n = 8) at 37 degrees c were 1.52 +/- 0.10%, 1.99 +/- 0.18%, and 1.01 +/- 0.10%, respectively. halothane mac was reduced by 26% in the presence of 70% n2o. at 29.9 +/- 0.2 degrees c, the mean mac value of halothane (0.85 +/- 0.11%) was ... | 1988 | 3369718 |
| connections of a vagal communicating branch in the ferret. i. pathways and cell body location. | in contrast to most other species, ferrets possess a single communicating branch connecting the dorsal and ventral vagal trunks immediately rostral to the diaphragm. this branch is being used in physiological studies of gastrointestinal function and emesis. however, the fibre routes which pass through this branch are not known. in this study, the afferent and efferent pathways within this supradiaphragmatic vagal communicating branch of the ferret were studied through the use of the horseradish ... | 1988 | 3370503 |
| cryptosporidiosis in ferrets. | the diagnosis of cryptosporidiosis in two ferrets who died from unrelated causes prompted a survey to determine the prevalence and incidence of the infection in ferrets at our facility. the survey of the existing ferret population and all new arrivals indicated cryptosporidiosis occurred as a subclinical disease in a high percentage of young ferrets: 40% of the ferret population and 38 to 100% of the new arrivals had cryptosporidial oocysts in their feces. the infection was found to persist for ... | 1988 | 3374090 |
| failure to detect gastric campylobacter-like organisms in a group of ferrets in new zealand. | 1988 | 3374906 |